DDX43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an ATP-dependent RNA helicase in the DEAD-box family and displays tumor-specific expression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)9.10652493
2piRNA metabolic process (GO:0034587)8.25871857
3DNA methylation involved in gamete generation (GO:0043046)6.59866548
4synaptonemal complex assembly (GO:0007130)6.31614922
5synaptonemal complex organization (GO:0070193)5.88745560
6male meiosis (GO:0007140)5.81014741
7nuclear pore complex assembly (GO:0051292)5.66618622
8nuclear pore organization (GO:0006999)5.65957590
9regulation of meiosis I (GO:0060631)5.39363790
10regulation of acrosome reaction (GO:0060046)5.11938878
11centriole replication (GO:0007099)4.98099528
12female gamete generation (GO:0007292)4.97923103
13chromosome organization involved in meiosis (GO:0070192)4.77932353
14meiotic nuclear division (GO:0007126)4.75013069
15negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.63824583
16positive regulation of meiosis (GO:0045836)4.49818324
17gene silencing by RNA (GO:0031047)4.43893732
18regulation of DNA methylation (GO:0044030)4.42165363
19pore complex assembly (GO:0046931)4.36030470
20positive regulation of meiotic cell cycle (GO:0051446)4.22622293
21male meiosis I (GO:0007141)4.21864696
22meiotic chromosome segregation (GO:0045132)4.18043881
23mitotic metaphase plate congression (GO:0007080)4.16922145
24regulation of retinoic acid receptor signaling pathway (GO:0048385)4.06427183
25attachment of spindle microtubules to kinetochore (GO:0008608)4.03883295
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.01628777
27DNA replication-dependent nucleosome organization (GO:0034723)4.01155407
28DNA replication-dependent nucleosome assembly (GO:0006335)4.01155407
29DNA replication checkpoint (GO:0000076)3.98278685
30centriole assembly (GO:0098534)3.96985355
31mitotic nuclear envelope disassembly (GO:0007077)3.96049419
32plasma membrane fusion (GO:0045026)3.95461952
33DNA alkylation (GO:0006305)3.91090454
34DNA methylation (GO:0006306)3.91090454
35regulation of posttranscriptional gene silencing (GO:0060147)3.89366182
36regulation of gene silencing by miRNA (GO:0060964)3.89366182
37regulation of gene silencing by RNA (GO:0060966)3.89366182
38mitotic chromosome condensation (GO:0007076)3.87740385
39protein localization to kinetochore (GO:0034501)3.79220059
40metaphase plate congression (GO:0051310)3.78017531
41meiotic cell cycle process (GO:1903046)3.76984591
42kinetochore organization (GO:0051383)3.76746819
43protein K6-linked ubiquitination (GO:0085020)3.76495184
44positive regulation of action potential (GO:0045760)3.76204117
45mitotic sister chromatid cohesion (GO:0007064)3.75156885
46regulation of DNA endoreduplication (GO:0032875)3.73936740
47reciprocal DNA recombination (GO:0035825)3.73432172
48reciprocal meiotic recombination (GO:0007131)3.73432172
49meiosis I (GO:0007127)3.72635531
50heterochromatin organization (GO:0070828)3.72485931
51membrane disassembly (GO:0030397)3.71972968
52nuclear envelope disassembly (GO:0051081)3.71972968
53regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.70133325
54protein K11-linked deubiquitination (GO:0035871)3.68788622
55chromatin remodeling at centromere (GO:0031055)3.67500313
56regulation of histone H3-K9 methylation (GO:0051570)3.67190002
57sister chromatid cohesion (GO:0007062)3.67008234
58gonadal mesoderm development (GO:0007506)3.66531561
59cilium or flagellum-dependent cell motility (GO:0001539)3.60663730
60binding of sperm to zona pellucida (GO:0007339)3.60607503
61protein localization to chromosome, centromeric region (GO:0071459)3.58205161
62positive regulation of uterine smooth muscle contraction (GO:0070474)3.52730995
63histone exchange (GO:0043486)3.52408710
64regulation of female gonad development (GO:2000194)3.50510367
65regulation of meiosis (GO:0040020)3.50298871
66gene silencing (GO:0016458)3.48492114
67regulation of RNA export from nucleus (GO:0046831)3.46751376
68histone H4-K12 acetylation (GO:0043983)3.41210375
69inner cell mass cell proliferation (GO:0001833)3.40113869
70DNA replication initiation (GO:0006270)3.40026043
71DNA replication-independent nucleosome organization (GO:0034724)3.38855374
72DNA replication-independent nucleosome assembly (GO:0006336)3.38855374
73regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.37864587
74DNA synthesis involved in DNA repair (GO:0000731)3.37792976
75regulation of chromosome segregation (GO:0051983)3.34057695
76pre-miRNA processing (GO:0031054)3.33362632
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.33172243
78regulation of meiotic cell cycle (GO:0051445)3.33159028
79kinetochore assembly (GO:0051382)3.31984749
80CENP-A containing nucleosome assembly (GO:0034080)3.29491370
81regulation of centriole replication (GO:0046599)3.29072174
82regulation of helicase activity (GO:0051095)3.28611008
83mitotic sister chromatid segregation (GO:0000070)3.26973804
84microtubule depolymerization (GO:0007019)3.23134083
85pyrimidine dimer repair (GO:0006290)3.22108909
86regulation of double-strand break repair via homologous recombination (GO:0010569)3.21664883
87DNA modification (GO:0006304)3.20396800
88spindle assembly involved in mitosis (GO:0090307)3.20298327
89maturation of SSU-rRNA (GO:0030490)3.20139060
90positive regulation of chromosome segregation (GO:0051984)3.19218927
91DNA methylation or demethylation (GO:0044728)3.17804405
92negative regulation of meiosis (GO:0045835)3.17563527
93ribosome assembly (GO:0042255)3.17097965
94meiotic cell cycle (GO:0051321)3.16656565
95regulation of mitotic metaphase/anaphase transition (GO:0030071)3.16621129
96negative regulation of chromosome segregation (GO:0051985)3.16435717
97protein localization to chromosome (GO:0034502)3.16016197
98monoubiquitinated protein deubiquitination (GO:0035520)3.15962097
99establishment of chromosome localization (GO:0051303)3.15205088
100negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.11644503
101negative regulation of sister chromatid segregation (GO:0033046)3.11644503
102negative regulation of mitotic sister chromatid separation (GO:2000816)3.11644503
103negative regulation of mitotic sister chromatid segregation (GO:0033048)3.11644503
104positive regulation of histone H3-K4 methylation (GO:0051571)3.10705051
105regulation of centrosome cycle (GO:0046605)3.10456993
106multicellular organism reproduction (GO:0032504)3.09185549
107regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.08960165
108DNA geometric change (GO:0032392)3.08697232
109DNA duplex unwinding (GO:0032508)3.06721308
110spindle checkpoint (GO:0031577)3.06616020
111mitotic spindle checkpoint (GO:0071174)3.05933194
112regulation of double-strand break repair (GO:2000779)3.04873653
113ATP-dependent chromatin remodeling (GO:0043044)3.04683207
114negative regulation of histone methylation (GO:0031061)3.04663363
115fusion of sperm to egg plasma membrane (GO:0007342)3.03747254
116regulation of spindle organization (GO:0090224)3.03114811
117sperm-egg recognition (GO:0035036)3.03032092
118spindle assembly checkpoint (GO:0071173)3.03025943
119retinal cone cell development (GO:0046549)3.02591720
120negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.01876686
121DNA strand elongation involved in DNA replication (GO:0006271)3.01831606
122mitotic spindle assembly checkpoint (GO:0007094)3.01381877
123histone H3-K9 methylation (GO:0051567)3.01151626
124ribosome biogenesis (GO:0042254)3.00666169
125resolution of meiotic recombination intermediates (GO:0000712)2.99123605
126regulation of uterine smooth muscle contraction (GO:0070472)2.98923271
127regulation of mitotic sister chromatid segregation (GO:0033047)2.98033293
128regulation of sister chromatid segregation (GO:0033045)2.98033293
129regulation of mitotic sister chromatid separation (GO:0010965)2.98033293
130oogenesis (GO:0048477)2.97466472
131embryonic body morphogenesis (GO:0010172)2.92732987
132positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.86099821
133positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.86099821
134positive regulation of mitotic sister chromatid separation (GO:1901970)2.86099821
135DNA deamination (GO:0045006)2.81927754
136melanin biosynthetic process (GO:0042438)2.81761577
137organelle membrane fusion (GO:0090174)2.81341799
138axoneme assembly (GO:0035082)2.79597901
139fertilization (GO:0009566)2.79172631
140germ cell development (GO:0007281)2.75986264
141spermatid development (GO:0007286)2.75261347
142negative regulation of DNA-dependent DNA replication (GO:2000104)2.71730219
143positive regulation of histone methylation (GO:0031062)2.70549938
144oocyte maturation (GO:0001556)2.66734874
145mismatch repair (GO:0006298)2.66605861
146DNA biosynthetic process (GO:0071897)2.65265613
147phosphorylated carbohydrate dephosphorylation (GO:0046838)2.59767456
148inositol phosphate dephosphorylation (GO:0046855)2.59767456
149nuclear division (GO:0000280)2.57892244
150secondary metabolite biosynthetic process (GO:0044550)2.56731972
151chromosome segregation (GO:0007059)2.56400766
152acrosome assembly (GO:0001675)2.55776893
153epithelial cilium movement (GO:0003351)2.55536717
154oocyte development (GO:0048599)2.52720009
155regulation of cilium movement (GO:0003352)2.47745562
156regulation of histone methylation (GO:0031060)2.46270597
157regulation of action potential (GO:0098900)2.45072926
158cell-cell recognition (GO:0009988)2.45061329

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.41003678
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.19676357
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.04970611
4EZH2_22144423_ChIP-Seq_EOC_Human4.86734328
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.80699538
6E2F4_17652178_ChIP-ChIP_JURKAT_Human4.08063593
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.42114602
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.19492611
9VDR_22108803_ChIP-Seq_LS180_Human2.88613399
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.82086304
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80262728
12ZNF274_21170338_ChIP-Seq_K562_Hela2.78750754
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.78403265
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.78403265
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.78403265
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.75883945
17GBX2_23144817_ChIP-Seq_PC3_Human2.62034135
18IGF1R_20145208_ChIP-Seq_DFB_Human2.57753009
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.48860573
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.38938872
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38422767
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.38322286
23AR_21909140_ChIP-Seq_LNCAP_Human2.32653780
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21027771
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18224590
26E2F1_21310950_ChIP-Seq_MCF-7_Human2.13743872
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.05947487
28MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02966160
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.02181448
30XRN2_22483619_ChIP-Seq_HELA_Human2.00087076
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97303591
32BCAT_22108803_ChIP-Seq_LS180_Human1.94625354
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.93538374
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91959646
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.90700304
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89293445
37SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.87469572
38VDR_23849224_ChIP-Seq_CD4+_Human1.85788975
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82696787
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80462525
41KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.79661478
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.79055780
43ER_23166858_ChIP-Seq_MCF-7_Human1.77435262
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.75578538
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72387472
46EWS_26573619_Chip-Seq_HEK293_Human1.72097806
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71559373
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70395870
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65675620
50RNF2_27304074_Chip-Seq_NSC_Mouse1.65167165
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.63466812
52CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.63258978
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.62619688
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61677154
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60998509
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59495759
57FOXP3_21729870_ChIP-Seq_TREG_Human1.56869361
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52825211
59KDM5A_27292631_Chip-Seq_BREAST_Human1.50681003
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50490553
61TCF4_23295773_ChIP-Seq_U87_Human1.48191410
62DCP1A_22483619_ChIP-Seq_HELA_Human1.47836833
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46454027
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.45511873
65TTF2_22483619_ChIP-Seq_HELA_Human1.43959130
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39930546
67CBP_20019798_ChIP-Seq_JUKART_Human1.39930546
68SMAD4_21741376_ChIP-Seq_EPCs_Human1.39852130
69TAF15_26573619_Chip-Seq_HEK293_Human1.39485806
70TP53_22573176_ChIP-Seq_HFKS_Human1.39393137
71NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.38276352
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37970507
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.36890412
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35494602
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35475100
76FOXA1_25329375_ChIP-Seq_VCAP_Human1.35475100
77AR_25329375_ChIP-Seq_VCAP_Human1.35053976
78HOXB7_26014856_ChIP-Seq_BT474_Human1.33977331
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33824322
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32901093
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32198493
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.32115366
83RUNX2_22187159_ChIP-Seq_PCA_Human1.32100009
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30741702
85HTT_18923047_ChIP-ChIP_STHdh_Human1.29889602
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29809097
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29554874
88GABP_19822575_ChIP-Seq_HepG2_Human1.29376352
89* P300_19829295_ChIP-Seq_ESCs_Human1.28363230
90E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26169982
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25959671
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25783053
93YY1_21170310_ChIP-Seq_MESCs_Mouse1.24668804
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24424983
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.23901360
96FOXH1_21741376_ChIP-Seq_EPCs_Human1.23772527
97ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23431885
98SMAD4_21799915_ChIP-Seq_A2780_Human1.23332653
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23232699
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23038145
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21875838
102STAT3_23295773_ChIP-Seq_U87_Human1.21873638
103ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20961389
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19893472
105ELK1_19687146_ChIP-ChIP_HELA_Human1.19869052
106MYC_22102868_ChIP-Seq_BL_Human1.18264477
107ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18040194
108GATA3_26560356_Chip-Seq_TH1_Human1.16722322
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15308178
110TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.14304212
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12723904
112TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.11643302
113ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10900702
114THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10881788
115SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10132780
116NFE2_27457419_Chip-Seq_LIVER_Mouse1.08931362
117RBPJ_21746931_ChIP-Seq_IB4_Human1.08570822
118TCF4_22108803_ChIP-Seq_LS180_Human1.06542616
119ETV1_20927104_ChIP-Seq_GIST48_Human1.06378130
120TAL1_26923725_Chip-Seq_HPCs_Mouse1.06209031
121TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04708153
122AR_20517297_ChIP-Seq_VCAP_Human1.04420929
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.03920123
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03328135
125HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02337337
126FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02256050
127CDX2_22108803_ChIP-Seq_LS180_Human1.01962166
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01354394
129SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00992997
130AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00456382
131* NCOR_22424771_ChIP-Seq_293T_Human1.00203780
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99641172
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97783031
134CIITA_25753668_ChIP-Seq_RAJI_Human0.95730952
135CRX_20693478_ChIP-Seq_RETINA_Mouse0.95477369
136TDRD3_21172665_ChIP-Seq_MCF-7_Human0.94903511
137ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94882769
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94571000
139SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94206515
140TFEB_21752829_ChIP-Seq_HELA_Human0.94147799
141PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.93806440
142FUS_26573619_Chip-Seq_HEK293_Human0.93581225
143PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93023438
144NANOG_18555785_Chip-Seq_ESCs_Mouse0.91510460
145SOX2_19829295_ChIP-Seq_ESCs_Human0.91175842
146NANOG_19829295_ChIP-Seq_ESCs_Human0.91175842
147TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90757095
148PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90745932
149FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90574510
150ERA_21632823_ChIP-Seq_H3396_Human0.90422404
151SMAD3_21741376_ChIP-Seq_EPCs_Human0.90398289
152GATA1_26923725_Chip-Seq_HPCs_Mouse0.90389511
153TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90185749
154GATA3_21878914_ChIP-Seq_MCF-7_Human0.89883714
155PKCTHETA_26484144_Chip-Seq_BREAST_Human0.88857065
156NANOG_21062744_ChIP-ChIP_HESCs_Human0.88386867
157DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88275513
158KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88046807
159SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86399472
160TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85938572
161POU5F1_16518401_ChIP-PET_MESCs_Mouse0.83266170
162SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82222445
163BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81254462
164NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79958868
165RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.79553600
166CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79427471
167HOXB4_20404135_ChIP-ChIP_EML_Mouse0.78053437
168MYB_26560356_Chip-Seq_TH1_Human0.74353091
169SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.71542922
170SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.69957334
171POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.69927529
172FLI1_27457419_Chip-Seq_LIVER_Mouse0.69308576
173MYC_18940864_ChIP-ChIP_HL60_Human0.68650620
174SOX2_18692474_ChIP-Seq_MESCs_Mouse0.68052575
175CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.67639518
176KAP1_27257070_Chip-Seq_ESCs_Mouse0.66864153
177KAP1_22055183_ChIP-Seq_ESCs_Mouse0.65958587

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.80858916
2MP0003693_abnormal_embryo_hatching4.67259635
3MP0010094_abnormal_chromosome_stability4.18817590
4MP0008057_abnormal_DNA_replication4.09580683
5MP0003111_abnormal_nucleus_morphology4.01738852
6MP0004957_abnormal_blastocyst_morpholog3.82134119
7MP0003077_abnormal_cell_cycle3.46121898
8MP0000372_irregular_coat_pigmentation3.40858502
9MP0008058_abnormal_DNA_repair3.39273375
10MP0002210_abnormal_sex_determination3.04188548
11MP0003786_premature_aging2.83512362
12MP0001929_abnormal_gametogenesis2.82489100
13MP0008995_early_reproductive_senescence2.74867148
14MP0003646_muscle_fatigue2.53784490
15MP0005410_abnormal_fertilization2.52644811
16MP0001145_abnormal_male_reproductive2.51953209
17MP0010352_gastrointestinal_tract_polyps2.48716015
18MP0008007_abnormal_cellular_replicative2.40121207
19MP0003698_abnormal_male_reproductive2.33429246
20MP0000015_abnormal_ear_pigmentation2.29324697
21MP0010307_abnormal_tumor_latency2.24493247
22MP0001730_embryonic_growth_arrest2.23876148
23MP0003950_abnormal_plasma_membrane2.20861241
24MP0000653_abnormal_sex_gland2.18430291
25MP0002653_abnormal_ependyma_morphology2.16428393
26MP0008932_abnormal_embryonic_tissue2.13260967
27MP0003123_paternal_imprinting2.09486419
28MP0000350_abnormal_cell_proliferation2.07813855
29MP0005174_abnormal_tail_pigmentation1.93899541
30MP0005075_abnormal_melanosome_morpholog1.91822481
31MP0002095_abnormal_skin_pigmentation1.85703347
32MP0005647_abnormal_sex_gland1.75279871
33MP0001672_abnormal_embryogenesis/_devel1.68290812
34MP0005380_embryogenesis_phenotype1.68290812
35MP0002102_abnormal_ear_morphology1.67253541
36MP0005085_abnormal_gallbladder_physiolo1.61688231
37MP0001873_stomach_inflammation1.60359550
38MP0002084_abnormal_developmental_patter1.54211208
39MP0001697_abnormal_embryo_size1.52664419
40MP0005395_other_phenotype1.47463665
41MP0002085_abnormal_embryonic_tissue1.45816389
42MP0003984_embryonic_growth_retardation1.45198696
43MP0004147_increased_porphyrin_level1.45184278
44MP0004197_abnormal_fetal_growth/weight/1.43728154
45MP0002161_abnormal_fertility/fecundity1.43277998
46MP0002088_abnormal_embryonic_growth/wei1.40448072
47MP0005076_abnormal_cell_differentiation1.39987687
48MP0002086_abnormal_extraembryonic_tissu1.39640608
49MP0003121_genomic_imprinting1.38962764
50MP0005623_abnormal_meninges_morphology1.38961984
51MP0002396_abnormal_hematopoietic_system1.38577475
52MP0003763_abnormal_thymus_physiology1.38573209
53MP0003890_abnormal_embryonic-extraembry1.38407200
54MP0003718_maternal_effect1.35909533
55MP0009046_muscle_twitch1.34341897
56MP0005551_abnormal_eye_electrophysiolog1.34336260
57MP0002080_prenatal_lethality1.30522306
58MP0005171_absent_coat_pigmentation1.29248429
59MP0001324_abnormal_eye_pigmentation1.28933870
60MP0003315_abnormal_perineum_morphology1.28656699
61MP0001984_abnormal_olfaction1.27689831
62MP0003183_abnormal_peptide_metabolism1.26397104
63MP0003806_abnormal_nucleotide_metabolis1.26272628
64MP0000313_abnormal_cell_death1.26201282
65MP0003136_yellow_coat_color1.23805006
66MP0001919_abnormal_reproductive_system1.22527457
67MP0002272_abnormal_nervous_system1.22116929
68MP0002928_abnormal_bile_duct1.20903017
69MP0002019_abnormal_tumor_incidence1.20213429
70MP0000703_abnormal_thymus_morphology1.19677765
71MP0004808_abnormal_hematopoietic_stem1.18458526
72MP0003787_abnormal_imprinting1.13772509
73MP0005423_abnormal_somatic_nervous1.13591828
74MP0005310_abnormal_salivary_gland1.13096719
75MP0000427_abnormal_hair_cycle1.12965823
76MP0003567_abnormal_fetal_cardiomyocyte1.12889718
77MP0004185_abnormal_adipocyte_glucose1.12222092
78MP0004142_abnormal_muscle_tone1.11224791
79MP0009745_abnormal_behavioral_response1.10088624
80MP0005408_hypopigmentation1.10051726
81MP0003941_abnormal_skin_development1.09388087
82MP0008789_abnormal_olfactory_epithelium1.07924118
83MP0002735_abnormal_chemical_nociception1.04146492
84MP0001119_abnormal_female_reproductive1.03744496
85MP0001293_anophthalmia1.02552877
86MP0003880_abnormal_central_pattern1.02322009
87MP0001188_hyperpigmentation1.00323500
88MP0002139_abnormal_hepatobiliary_system0.99384894
89MP0003195_calcinosis0.97402351
90MP0009333_abnormal_splenocyte_physiolog0.95309582
91MP0000490_abnormal_crypts_of0.94549526
92MP0000631_abnormal_neuroendocrine_gland0.92907714
93MP0002160_abnormal_reproductive_system0.91762289
94MP0001968_abnormal_touch/_nociception0.91492631
95MP0004233_abnormal_muscle_weight0.90703511
96MP0001849_ear_inflammation0.89351988
97MP0003252_abnormal_bile_duct0.89172744
98MP0003119_abnormal_digestive_system0.88095350
99MP0005409_darkened_coat_color0.88090263
100MP0002009_preneoplasia0.87497429
101MP0010368_abnormal_lymphatic_system0.86760442
102MP0003879_abnormal_hair_cell0.85644194
103MP0000569_abnormal_digit_pigmentation0.85071190
104MP0005646_abnormal_pituitary_gland0.85034621
105MP0004264_abnormal_extraembryonic_tissu0.84848490
106MP0004885_abnormal_endolymph0.84399008
107MP0002398_abnormal_bone_marrow0.83523710
108MP0009697_abnormal_copulation0.82994224
109MP0002064_seizures0.82578074
110MP0010386_abnormal_urinary_bladder0.82351497
111MP0003699_abnormal_female_reproductive0.80659947
112MP0006292_abnormal_olfactory_placode0.79937034
113MP0009703_decreased_birth_body0.79710568
114MP0001727_abnormal_embryo_implantation0.79700185
115MP0009379_abnormal_foot_pigmentation0.78729513
116MP0009672_abnormal_birth_weight0.78370528
117MP0000371_diluted_coat_color0.77995567
118MP0003221_abnormal_cardiomyocyte_apopto0.76809435
119MP0002638_abnormal_pupillary_reflex0.76523619
120MP0003878_abnormal_ear_physiology0.76416082
121MP0005377_hearing/vestibular/ear_phenot0.76416082
122MP0002722_abnormal_immune_system0.74609928
123MP0005671_abnormal_response_to0.73842085
124MP0003936_abnormal_reproductive_system0.71284110
125MP0003937_abnormal_limbs/digits/tail_de0.70444213
126MP0003448_altered_tumor_morphology0.70297826
127MP0000689_abnormal_spleen_morphology0.70015012
128MP0006036_abnormal_mitochondrial_physio0.68567692
129MP0001486_abnormal_startle_reflex0.67761802
130MP0000383_abnormal_hair_follicle0.67728555
131MP0005389_reproductive_system_phenotype0.66555652
132MP0005621_abnormal_cell_physiology0.66365996
133MP0001545_abnormal_hematopoietic_system0.65854836
134MP0005397_hematopoietic_system_phenotyp0.65854836
135MP0002138_abnormal_hepatobiliary_system0.65840881
136MP0001661_extended_life_span0.65608952
137MP0005384_cellular_phenotype0.64807075
138MP0001501_abnormal_sleep_pattern0.62636296
139MP0002229_neurodegeneration0.61524595
140MP0002006_tumorigenesis0.60638511
141MP0002234_abnormal_pharynx_morphology0.59611143
142MP0002092_abnormal_eye_morphology0.59383147
143MP0001915_intracranial_hemorrhage0.59219271
144MP0000432_abnormal_head_morphology0.58894146
145MP0000358_abnormal_cell_content/0.58360395
146MP0009278_abnormal_bone_marrow0.57793353
147MP0004043_abnormal_pH_regulation0.57467151
148MP0000858_altered_metastatic_potential0.56767329
149MP0005499_abnormal_olfactory_system0.55824386
150MP0005394_taste/olfaction_phenotype0.55824386
151MP0003705_abnormal_hypodermis_morpholog0.54686551
152MP0002693_abnormal_pancreas_physiology0.54202653
153MP0002429_abnormal_blood_cell0.52814630
154MP0003861_abnormal_nervous_system0.52721607
155MP0001986_abnormal_taste_sensitivity0.52398173
156MP0002736_abnormal_nociception_after0.51946316
157MP0005253_abnormal_eye_physiology0.51945393
158MP0003566_abnormal_cell_adhesion0.51798891
159MP0001286_abnormal_eye_development0.51449682
160MP0005666_abnormal_adipose_tissue0.50490115
161MP0000716_abnormal_immune_system0.49975226
162MP0002277_abnormal_respiratory_mucosa0.47180101
163MP0002697_abnormal_eye_size0.44390197
164MP0004381_abnormal_hair_follicle0.43084122
165MP0000477_abnormal_intestine_morphology0.42574014

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.62956895
2Hypoplasia of the fovea (HP:0007750)4.36687448
3Aplasia/Hypoplasia of the fovea (HP:0008060)4.36687448
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.25433109
5Azoospermia (HP:0000027)4.17649014
6Impulsivity (HP:0100710)4.14071986
7Abnormality of the labia minora (HP:0012880)4.04743683
8Abnormal spermatogenesis (HP:0008669)3.99905615
9Lip pit (HP:0100267)3.98503935
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.88255368
11Abnormality of the fovea (HP:0000493)3.86005648
12Birth length less than 3rd percentile (HP:0003561)3.81826254
13Supernumerary spleens (HP:0009799)3.74935726
14Abnormality of chromosome stability (HP:0003220)3.72741806
15Abnormality of the lower motor neuron (HP:0002366)3.72450592
16Aplastic anemia (HP:0001915)3.52806281
17Ependymoma (HP:0002888)3.48439550
18Meckel diverticulum (HP:0002245)3.45866993
19Breast hypoplasia (HP:0003187)3.41737032
20Aplasia/Hypoplasia of the macula (HP:0008059)3.39152703
21Absent radius (HP:0003974)3.32994172
22Carpal bone hypoplasia (HP:0001498)3.29182845
23Facial hemangioma (HP:0000329)3.27932737
24Median cleft lip (HP:0000161)3.27787117
25Abnormality of the preputium (HP:0100587)3.27010827
26Decreased central vision (HP:0007663)3.26592843
27Posterior subcapsular cataract (HP:0007787)3.26545277
28Aplasia/Hypoplasia of the uvula (HP:0010293)3.26153138
29Degeneration of anterior horn cells (HP:0002398)3.21564293
30Abnormality of the anterior horn cell (HP:0006802)3.21564293
31Abnormality of the ileum (HP:0001549)3.20563539
32Dynein arm defect of respiratory motile cilia (HP:0012255)3.16076026
33Absent/shortened dynein arms (HP:0200106)3.16076026
34Ectopic kidney (HP:0000086)3.12862938
35Absent forearm bone (HP:0003953)3.12371925
36Aplasia involving forearm bones (HP:0009822)3.12371925
37Aplasia/Hypoplasia affecting the retina (HP:0008061)3.09554342
38Limb dystonia (HP:0002451)3.07559135
39Absent thumb (HP:0009777)3.05346105
40Patellar aplasia (HP:0006443)3.00340828
41Osteomalacia (HP:0002749)2.98433045
42Pancreatic cysts (HP:0001737)2.96335046
43Medulloblastoma (HP:0002885)2.94412099
44Abnormality of midbrain morphology (HP:0002418)2.94205331
45Molar tooth sign on MRI (HP:0002419)2.94205331
46Horizontal nystagmus (HP:0000666)2.92054006
47Selective tooth agenesis (HP:0001592)2.90338329
48Congenital stationary night blindness (HP:0007642)2.88450474
49Sensory axonal neuropathy (HP:0003390)2.78072136
50Aplasia/Hypoplasia of the patella (HP:0006498)2.74819688
51Microretrognathia (HP:0000308)2.72954934
52Small intestinal stenosis (HP:0012848)2.72740251
53Duodenal stenosis (HP:0100867)2.72740251
54Neoplasm of the oral cavity (HP:0100649)2.60356663
55Rhabdomyosarcoma (HP:0002859)2.57923435
56Astrocytoma (HP:0009592)2.54680947
57Abnormality of the astrocytes (HP:0100707)2.54680947
58Proximal placement of thumb (HP:0009623)2.54061035
59Reticulocytopenia (HP:0001896)2.52491840
60Prominent nose (HP:0000448)2.50412011
61Oligodactyly (HP:0012165)2.49239989
62Gonadotropin excess (HP:0000837)2.47633772
63Abnormal respiratory motile cilium physiology (HP:0012261)2.47546132
64Amyotrophic lateral sclerosis (HP:0007354)2.47185932
65Myelodysplasia (HP:0002863)2.46866050
66Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.45802768
67Rhinitis (HP:0012384)2.45714874
68Infertility (HP:0000789)2.45420280
69Heterotopia (HP:0002282)2.41007879
70Abnormal respiratory epithelium morphology (HP:0012253)2.39732562
71Abnormal respiratory motile cilium morphology (HP:0005938)2.39732562
72Nasal polyposis (HP:0100582)2.38881840
73Deviation of the thumb (HP:0009603)2.36486291
74Degeneration of the lateral corticospinal tracts (HP:0002314)2.36235590
75Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.36235590
76Abnormality of alanine metabolism (HP:0010916)2.34859636
77Hyperalaninemia (HP:0003348)2.34859636
78Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.34859636
79Basal cell carcinoma (HP:0002671)2.33623580
80Attenuation of retinal blood vessels (HP:0007843)2.32629178
81Agnosia (HP:0010524)2.31039558
82Intrahepatic cholestasis (HP:0001406)2.30747075
83Atrophy/Degeneration involving motor neurons (HP:0007373)2.30559576
8411 pairs of ribs (HP:0000878)2.30398325
85Upper motor neuron abnormality (HP:0002127)2.30329854
86Sloping forehead (HP:0000340)2.30059548
87Aplasia/Hypoplasia of the tibia (HP:0005772)2.29688172
88Volvulus (HP:0002580)2.28894690
89Biliary tract neoplasm (HP:0100574)2.26235932
90Glioma (HP:0009733)2.25850701
91Cafe-au-lait spot (HP:0000957)2.25512524
92Missing ribs (HP:0000921)2.24663476
93Truncal obesity (HP:0001956)2.24335486
94Horseshoe kidney (HP:0000085)2.23271583
95Abnormality of the duodenum (HP:0002246)2.23049604
96Abnormality of the carotid arteries (HP:0005344)2.22106574
97Short thumb (HP:0009778)2.19976054
98Aplasia/hypoplasia of the humerus (HP:0006507)2.19207526
99Nephroblastoma (Wilms tumor) (HP:0002667)2.18492377
100Clubbing of toes (HP:0100760)2.17219020
101Rimmed vacuoles (HP:0003805)2.14044345
102Hypoplasia of the uterus (HP:0000013)2.12894685
103Papillary thyroid carcinoma (HP:0002895)2.12630903
104Triphalangeal thumb (HP:0001199)2.12272945
105Abnormality of the fingertips (HP:0001211)2.11778791
1063-Methylglutaconic aciduria (HP:0003535)2.11323751
107Colon cancer (HP:0003003)2.09915773
108Supernumerary ribs (HP:0005815)2.09649498
109Short tibia (HP:0005736)2.09162788
110Congenital sensorineural hearing impairment (HP:0008527)2.08999520
111Type I diabetes mellitus (HP:0100651)2.08316293
112T lymphocytopenia (HP:0005403)2.08152920
113Abnormality of the corticospinal tract (HP:0002492)2.06734764
114Premature ovarian failure (HP:0008209)2.05930074
115Cerebral hypomyelination (HP:0006808)2.05601436
116Oligodactyly (hands) (HP:0001180)2.05304365
117Bone marrow hypocellularity (HP:0005528)2.02267928
118Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01742877
119Supernumerary bones of the axial skeleton (HP:0009144)2.01025705
120Neoplasm of striated muscle (HP:0009728)2.00353433
121Sandal gap (HP:0001852)2.00003067
122Abnormality of the renal collecting system (HP:0004742)1.99937632
123Shoulder girdle muscle weakness (HP:0003547)1.99813227
124Astigmatism (HP:0000483)1.99093542
125Hypoplasia of the radius (HP:0002984)1.98812027
126Abnormal lung lobation (HP:0002101)1.98787010
127Hyperglycinuria (HP:0003108)1.98359486
128Combined immunodeficiency (HP:0005387)1.97990090
129Embryonal renal neoplasm (HP:0011794)1.97057812
130Shawl scrotum (HP:0000049)1.96120489
131Dysphonia (HP:0001618)1.95306391
132Squamous cell carcinoma (HP:0002860)1.94607421
133Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.93406500
134Increased nuchal translucency (HP:0010880)1.93379269
135Poor speech (HP:0002465)1.91858822
136Spinal muscular atrophy (HP:0007269)1.91751873
137Overlapping toe (HP:0001845)1.91284435
138Neoplasm of the pancreas (HP:0002894)1.91195454
139Anal stenosis (HP:0002025)1.90388241
140Abnormal rod and cone electroretinograms (HP:0008323)1.90295045
141Abnormality of DNA repair (HP:0003254)1.89908194
142Fair hair (HP:0002286)1.89729005
143Abnormal ciliary motility (HP:0012262)1.89644097
144Short humerus (HP:0005792)1.88124095
145Capillary hemangiomas (HP:0005306)1.88090282
146Ocular albinism (HP:0001107)1.87693134
147Duplicated collecting system (HP:0000081)1.87642589
148Generalized hypopigmentation of hair (HP:0011358)1.87577246
149Abnormality of T cell number (HP:0011839)1.87343379
150Gaze-evoked nystagmus (HP:0000640)1.85499089
151Aplasia/hypoplasia of the uterus (HP:0008684)1.84647296
152Male infertility (HP:0003251)1.81867122
153Photophobia (HP:0000613)1.81518475
154Choroideremia (HP:0001139)1.74559332
155Type II lissencephaly (HP:0007260)1.74557821
156Subcapsular cataract (HP:0000523)1.70486668
157Small hand (HP:0200055)1.69800635
158Cystic liver disease (HP:0006706)1.69559530
159Medial flaring of the eyebrow (HP:0010747)1.69148252
160Preaxial hand polydactyly (HP:0001177)1.68980367
161Nephrogenic diabetes insipidus (HP:0009806)1.68257512
162Abnormal biliary tract physiology (HP:0012439)1.67972002
163Bile duct proliferation (HP:0001408)1.67972002
164Progressive inability to walk (HP:0002505)1.66966428
165Severe visual impairment (HP:0001141)1.65798948
166Absent septum pellucidum (HP:0001331)1.65140842
167Pendular nystagmus (HP:0012043)1.64965917
168Albinism (HP:0001022)1.64565999

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.72995400
2CDC74.24483351
3WEE13.35760896
4NEK23.35249512
5MAP3K93.31160607
6ACVR1B3.25359235
7PDK33.24627245
8PDK43.24627245
9BUB12.82882889
10SRPK12.62663410
11CAMKK22.61601565
12ZAK2.50245696
13BRD42.41386815
14TTK2.37504451
15PDK22.24153709
16PNCK2.13438123
17EIF2AK12.11789126
18CDK192.05579751
19PLK12.04178247
20TAOK31.98225107
21PLK41.88766630
22BRAF1.84047057
23NEK61.83450461
24FRK1.82524749
25EPHA41.72311581
26NUAK11.70939230
27CHEK11.66264903
28MAP3K41.65077161
29CDK71.64413040
30NEK11.62126954
31CHEK21.61628444
32PINK11.59732249
33ATR1.56809982
34MKNK21.49609681
35BRSK21.46540604
36CDK41.43518006
37DYRK31.43166421
38TSSK61.42694156
39PLK31.41869433
40BLK1.41327078
41TXK1.40703054
42SIK21.38184102
43MAP3K131.36384682
44AURKB1.36141076
45GRK71.31935626
46RAF11.30850260
47DMPK1.30101997
48ATM1.29891707
49AKT31.28737729
50ALK1.26833368
51TYRO31.22803206
52STK41.21390567
53STK101.21293757
54STK31.18673709
55MET1.16128133
56ADRBK21.15513306
57VRK11.14612274
58TESK21.14240746
59MARK31.11454543
60MELK1.10728960
61MAP3K51.10489818
62GRK11.10409489
63CDK21.07630441
64PASK1.06437214
65EPHA21.05042793
66PRKCG1.01692158
67MUSK0.99927985
68ARAF0.99020392
69KDR0.96118866
70MAP3K80.93795538
71MKNK10.91729580
72PBK0.87823453
73ICK0.85951386
74STK38L0.83912969
75FES0.83879692
76CDK10.80638188
77CDK60.79041069
78WNK40.78072722
79RPS6KB20.77750735
80BRSK10.77216813
81EIF2AK30.76874247
82MTOR0.72716446
83MAPK130.71668656
84NTRK30.69597124
85NLK0.69086838
86PIM10.69075011
87MAP4K10.68349871
88MAP3K60.67341374
89NME20.67150098
90PRKCH0.66085645
91BMPR1B0.64447380
92CSNK2A20.63699158
93PRKCQ0.63654780
94AURKA0.62490016
95CAMK1G0.62053749
96TESK10.61571622
97CSNK1D0.61470911
98CAMK2A0.61340790
99CAMKK10.59847385
100PAK40.59075776
101MAP3K20.58099014
102CDK90.57241350
103NEK90.54676964
104WNK10.54427551
105CLK10.54390636
106PDK10.54006043
107CSF1R0.53302749
108PLK20.52323551
109CDK80.51544321
110CSNK1E0.51383530
111PRKCZ0.51050456
112ADRBK10.48810725
113PRKDC0.47466893
114STK390.47360431
115KSR20.47133387
116RPS6KA40.46858880
117PTK2B0.45316191
118PIK3CA0.44341146
119CSNK2A10.43813101
120CHUK0.43512024
121KSR10.43510884
122OXSR10.41969454
123MAPK140.41312765
124CAMK40.41198070
125CSK0.39187892
126PKN10.38740130
127MOS0.38291359
128GSK3B0.37441562
129CAMK1D0.36675790
130MST40.36243158
131FGR0.35652140
132RPS6KB10.35564391
133PRKG10.35136435
134LATS10.34907488
135SGK10.33751406
136CAMK10.33559966
137JAK30.33110566
138PRKACA0.32827926
139TGFBR10.32297439
140TNK20.32079933
141ZAP700.31880925
142LCK0.30931564
143PRKCI0.30885797
144WNK30.29340800
145STK380.28925844
146PRKD30.28802846
147TLK10.27770240
148JAK10.27162183
149ITK0.26657113
150EEF2K0.25894941
151PAK10.25676079
152TYK20.25359483
153MAPK10.24731909
154RPS6KA50.23164329
155TAOK10.22953729
156LATS20.22744614
157SCYL20.20302858
158MAPK80.19025025
159AKT10.18972774
160GRK60.18839672
161MAPK100.18539786
162DYRK20.18467056

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.72643940
2DNA replication_Homo sapiens_hsa030303.81109639
3Mismatch repair_Homo sapiens_hsa034303.72046616
4RNA transport_Homo sapiens_hsa030133.60877766
5Basal transcription factors_Homo sapiens_hsa030223.38588880
6RNA polymerase_Homo sapiens_hsa030203.35846576
7Homologous recombination_Homo sapiens_hsa034403.32333675
8Spliceosome_Homo sapiens_hsa030403.22425391
9Fanconi anemia pathway_Homo sapiens_hsa034603.03470181
10Regulation of autophagy_Homo sapiens_hsa041402.93514156
11Cell cycle_Homo sapiens_hsa041102.91499735
12Nucleotide excision repair_Homo sapiens_hsa034202.74753769
13mRNA surveillance pathway_Homo sapiens_hsa030152.64679671
14Base excision repair_Homo sapiens_hsa034102.12564875
15One carbon pool by folate_Homo sapiens_hsa006702.09337555
16Pyrimidine metabolism_Homo sapiens_hsa002402.06373473
17Non-homologous end-joining_Homo sapiens_hsa034502.04971933
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.02327292
19Vitamin B6 metabolism_Homo sapiens_hsa007502.02051569
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.99070053
21RNA degradation_Homo sapiens_hsa030181.98593867
22Protein export_Homo sapiens_hsa030601.86103003
23Phototransduction_Homo sapiens_hsa047441.84216352
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.82374925
25Propanoate metabolism_Homo sapiens_hsa006401.79686854
26p53 signaling pathway_Homo sapiens_hsa041151.73543933
27Nicotine addiction_Homo sapiens_hsa050331.72000879
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.63898122
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62956031
30Proteasome_Homo sapiens_hsa030501.59088837
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.57558383
32Caffeine metabolism_Homo sapiens_hsa002321.54019437
33Ribosome_Homo sapiens_hsa030101.51791758
34Antigen processing and presentation_Homo sapiens_hsa046121.48245452
35Oocyte meiosis_Homo sapiens_hsa041141.44860295
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34267408
37Fatty acid metabolism_Homo sapiens_hsa012121.33941966
38Epstein-Barr virus infection_Homo sapiens_hsa051691.31422656
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.30110362
40ABC transporters_Homo sapiens_hsa020101.27057844
41Ovarian steroidogenesis_Homo sapiens_hsa049131.22363921
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.21933008
43Herpes simplex infection_Homo sapiens_hsa051681.20745163
44Folate biosynthesis_Homo sapiens_hsa007901.18538658
45Fatty acid elongation_Homo sapiens_hsa000621.17622316
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15577888
47Olfactory transduction_Homo sapiens_hsa047401.13322705
48Purine metabolism_Homo sapiens_hsa002301.13189673
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12983073
50Primary immunodeficiency_Homo sapiens_hsa053401.09129838
51beta-Alanine metabolism_Homo sapiens_hsa004101.08596704
52Taste transduction_Homo sapiens_hsa047421.05612913
53Viral carcinogenesis_Homo sapiens_hsa052031.01788193
54Selenocompound metabolism_Homo sapiens_hsa004501.01443525
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.98203349
56Circadian rhythm_Homo sapiens_hsa047100.97383080
57T cell receptor signaling pathway_Homo sapiens_hsa046600.94466603
58Systemic lupus erythematosus_Homo sapiens_hsa053220.93214002
59HTLV-I infection_Homo sapiens_hsa051660.91477880
60Dorso-ventral axis formation_Homo sapiens_hsa043200.89704718
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86437295
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86182959
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82104907
64Sulfur relay system_Homo sapiens_hsa041220.81862973
65Fatty acid degradation_Homo sapiens_hsa000710.80957526
66Fatty acid biosynthesis_Homo sapiens_hsa000610.80818031
67Thyroid cancer_Homo sapiens_hsa052160.80055295
68Oxidative phosphorylation_Homo sapiens_hsa001900.78593994
69Tryptophan metabolism_Homo sapiens_hsa003800.77028930
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74687862
71MicroRNAs in cancer_Homo sapiens_hsa052060.72797416
72Pentose phosphate pathway_Homo sapiens_hsa000300.68678808
73Parkinsons disease_Homo sapiens_hsa050120.68094655
74Graft-versus-host disease_Homo sapiens_hsa053320.67996980
75Measles_Homo sapiens_hsa051620.67879387
76Cardiac muscle contraction_Homo sapiens_hsa042600.66325640
77Notch signaling pathway_Homo sapiens_hsa043300.65845708
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65468032
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.64358296
80Colorectal cancer_Homo sapiens_hsa052100.63266516
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62490687
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60571780
83Adherens junction_Homo sapiens_hsa045200.56444269
84TGF-beta signaling pathway_Homo sapiens_hsa043500.54850057
85Small cell lung cancer_Homo sapiens_hsa052220.54444204
86Biosynthesis of amino acids_Homo sapiens_hsa012300.54352858
87Influenza A_Homo sapiens_hsa051640.53638248
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53427607
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.52804524
90Morphine addiction_Homo sapiens_hsa050320.52163291
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.51980858
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.50736736
93Viral myocarditis_Homo sapiens_hsa054160.50666673
94Lysine degradation_Homo sapiens_hsa003100.50644624
95mTOR signaling pathway_Homo sapiens_hsa041500.50120171
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.49546370
97Amphetamine addiction_Homo sapiens_hsa050310.49308427
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49303434
99Nitrogen metabolism_Homo sapiens_hsa009100.47525564
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46427394
101Autoimmune thyroid disease_Homo sapiens_hsa053200.46386007
102MAPK signaling pathway_Homo sapiens_hsa040100.45550267
103Prostate cancer_Homo sapiens_hsa052150.44526683
104FoxO signaling pathway_Homo sapiens_hsa040680.43261751
105Collecting duct acid secretion_Homo sapiens_hsa049660.41286941
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41198303
107Acute myeloid leukemia_Homo sapiens_hsa052210.40693689
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40034171
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.39932964
110Calcium signaling pathway_Homo sapiens_hsa040200.39735191
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.39589924
112Hippo signaling pathway_Homo sapiens_hsa043900.37535813
113Pancreatic cancer_Homo sapiens_hsa052120.36601414
114Allograft rejection_Homo sapiens_hsa053300.36430501
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.36095927
116Ether lipid metabolism_Homo sapiens_hsa005650.35395007
117Chronic myeloid leukemia_Homo sapiens_hsa052200.33229133
118Metabolic pathways_Homo sapiens_hsa011000.32142665
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31069161
120Mineral absorption_Homo sapiens_hsa049780.30238379
121Tyrosine metabolism_Homo sapiens_hsa003500.29990373
122Sphingolipid metabolism_Homo sapiens_hsa006000.29618677
123Non-small cell lung cancer_Homo sapiens_hsa052230.29086875
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27750369
125Hepatitis B_Homo sapiens_hsa051610.27211683
126Apoptosis_Homo sapiens_hsa042100.26681620
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25491095
128Basal cell carcinoma_Homo sapiens_hsa052170.24973020
129Tight junction_Homo sapiens_hsa045300.24693155
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.24521219
131Pathways in cancer_Homo sapiens_hsa052000.24174562
132HIF-1 signaling pathway_Homo sapiens_hsa040660.23656898
133Hematopoietic cell lineage_Homo sapiens_hsa046400.23119497
134Butanoate metabolism_Homo sapiens_hsa006500.22912830
135Insulin secretion_Homo sapiens_hsa049110.22781743
136Renal cell carcinoma_Homo sapiens_hsa052110.22764604
137Linoleic acid metabolism_Homo sapiens_hsa005910.22654397
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22585805
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22191916
140Oxytocin signaling pathway_Homo sapiens_hsa049210.21813495
141Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21141396
142Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.20915237
143Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20323175
144Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20238392
145Endometrial cancer_Homo sapiens_hsa052130.19377398
146cAMP signaling pathway_Homo sapiens_hsa040240.18552206
147NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18460203
148Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17036408
149Alzheimers disease_Homo sapiens_hsa050100.16431623
150B cell receptor signaling pathway_Homo sapiens_hsa046620.16111339
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.15884085
152Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.15268227
153Alcoholism_Homo sapiens_hsa050340.13695403
154Wnt signaling pathway_Homo sapiens_hsa043100.12533067
155Huntingtons disease_Homo sapiens_hsa050160.12092840
156Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10085573
157Legionellosis_Homo sapiens_hsa051340.10006671
158Inositol phosphate metabolism_Homo sapiens_hsa005620.09618797
159alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09554532

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