DDX42

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Two transcript variants encoding the same protein have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.56147543
2nuclear pore organization (GO:0006999)5.41185387
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.88703474
4pre-miRNA processing (GO:0031054)4.46079580
5mitotic sister chromatid cohesion (GO:0007064)4.43567264
6DNA unwinding involved in DNA replication (GO:0006268)4.37261399
7negative regulation of histone methylation (GO:0031061)4.31260488
8pore complex assembly (GO:0046931)4.17345558
9regulation of histone H3-K27 methylation (GO:0061085)4.14605772
10regulation of histone H3-K9 methylation (GO:0051570)4.03410095
11negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.72567009
12protein localization to kinetochore (GO:0034501)3.66809320
13DNA geometric change (GO:0032392)3.64587769
14histone H3-K36 demethylation (GO:0070544)3.64004241
15Golgi transport vesicle coating (GO:0048200)3.63594492
16COPI coating of Golgi vesicle (GO:0048205)3.63594492
17dosage compensation (GO:0007549)3.62829448
18DNA duplex unwinding (GO:0032508)3.61711198
19mitotic nuclear envelope disassembly (GO:0007077)3.58287254
20heterochromatin organization (GO:0070828)3.53749274
21histone H4-K12 acetylation (GO:0043983)3.51707901
22nuclear envelope disassembly (GO:0051081)3.49613216
23membrane disassembly (GO:0030397)3.49613216
24negative regulation of RNA splicing (GO:0033119)3.46729500
25peptidyl-lysine dimethylation (GO:0018027)3.43682181
26sister chromatid segregation (GO:0000819)3.41125207
27focal adhesion assembly (GO:0048041)3.37244317
28cell-substrate adherens junction assembly (GO:0007045)3.37244317
29spliceosomal tri-snRNP complex assembly (GO:0000244)3.35228586
30adherens junction assembly (GO:0034333)3.35176123
31mitotic chromosome condensation (GO:0007076)3.34215643
32chromatin assembly (GO:0031497)3.31515376
33DNA topological change (GO:0006265)3.30725722
34regulation of RNA export from nucleus (GO:0046831)3.29195043
35negative regulation of DNA repair (GO:0045738)3.27914668
36RNA stabilization (GO:0043489)3.26239831
37mRNA stabilization (GO:0048255)3.26239831
38cellular protein complex localization (GO:0034629)3.25902235
39glucocorticoid receptor signaling pathway (GO:0042921)3.24556234
40planar cell polarity pathway involved in neural tube closure (GO:0090179)3.22511237
41regulation of DNA endoreduplication (GO:0032875)3.21754334
42negative regulation of mRNA processing (GO:0050686)3.20893859
43regulation of helicase activity (GO:0051095)3.19218256
44histone H3-K9 demethylation (GO:0033169)3.19132689
45regulation of sister chromatid cohesion (GO:0007063)3.16054167
46regulation of glucose import in response to insulin stimulus (GO:2001273)3.15878750
47cellular response to epidermal growth factor stimulus (GO:0071364)3.15844517
48positive regulation of RNA splicing (GO:0033120)3.14858310
49DNA replication-dependent nucleosome assembly (GO:0006335)3.10152073
50DNA replication-dependent nucleosome organization (GO:0034723)3.10152073
51protein complex localization (GO:0031503)3.06879759
52regulation of translational fidelity (GO:0006450)3.05022432
53regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.04417014
54response to epidermal growth factor (GO:0070849)3.03661334
55histone H4-K8 acetylation (GO:0043982)3.03325109
56histone H4-K5 acetylation (GO:0043981)3.03325109
57protein export from nucleus (GO:0006611)3.02489748
58IMP biosynthetic process (GO:0006188)3.01597069
59alternative mRNA splicing, via spliceosome (GO:0000380)3.00706842
60protein localization to chromosome, centromeric region (GO:0071459)2.98899590
61NLS-bearing protein import into nucleus (GO:0006607)2.96073384
62negative regulation of histone modification (GO:0031057)2.95755232
63negative regulation of mRNA metabolic process (GO:1903312)2.92042029
64nucleosome disassembly (GO:0006337)2.91443124
65protein-DNA complex disassembly (GO:0032986)2.91443124
66mRNA splice site selection (GO:0006376)2.90629155
67chromosome condensation (GO:0030261)2.87887377
68regulation of NFAT protein import into nucleus (GO:0051532)2.86701642
69histone H2A monoubiquitination (GO:0035518)2.84120954
70DNA conformation change (GO:0071103)2.84092075
71positive regulation of mitotic sister chromatid separation (GO:1901970)2.82527272
72positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.82527272
73positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.82527272
74cell-substrate junction assembly (GO:0007044)2.81565453
75mitotic sister chromatid segregation (GO:0000070)2.80254430
76activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.80009679
77cytoskeletal anchoring at plasma membrane (GO:0007016)2.79960876
78positive regulation of nuclease activity (GO:0032075)2.79547728
79COPII vesicle coating (GO:0048208)2.79369636
80regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.79133901
81regulation of mammary gland epithelial cell proliferation (GO:0033599)2.78263510
82folic acid-containing compound biosynthetic process (GO:0009396)2.77562489
83negative regulation of chromatin modification (GO:1903309)2.76890443
84regulation of translational termination (GO:0006449)2.75704343
85regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.75692125
86regulation of gene silencing by RNA (GO:0060966)2.75533565
87regulation of posttranscriptional gene silencing (GO:0060147)2.75533565
88regulation of gene silencing by miRNA (GO:0060964)2.75533565
89activation of Rac GTPase activity (GO:0032863)2.75044068
90regulation of DNA damage checkpoint (GO:2000001)2.73942574
91formation of translation preinitiation complex (GO:0001731)2.73142912
92regulation of centriole replication (GO:0046599)2.71831333
93mRNA transport (GO:0051028)2.71666032
94nuclear envelope organization (GO:0006998)2.71058728
95histone H4-K16 acetylation (GO:0043984)2.70635925
96corticosteroid receptor signaling pathway (GO:0031958)2.69926789
97regulation of spindle organization (GO:0090224)2.68753431
98regulation of mRNA stability (GO:0043488)2.68416132
99histone lysine demethylation (GO:0070076)2.67865398
100stress granule assembly (GO:0034063)2.67517690
101embryonic camera-type eye morphogenesis (GO:0048596)2.67474687
102regulation of mitotic spindle organization (GO:0060236)2.65899907
103negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.65739358
104negative regulation of translation, ncRNA-mediated (GO:0040033)2.65739358
105regulation of translation, ncRNA-mediated (GO:0045974)2.65739358
106positive regulation of SMAD protein import into nucleus (GO:0060391)2.64489640
107translesion synthesis (GO:0019985)2.64093236
108embryonic eye morphogenesis (GO:0048048)2.63976999
109germ cell migration (GO:0008354)2.63956534
110maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.63699377
111proline biosynthetic process (GO:0006561)2.63388127
112chromatin assembly or disassembly (GO:0006333)2.62561392
113histone mRNA catabolic process (GO:0071044)2.62308055
114insulin-like growth factor receptor signaling pathway (GO:0048009)2.61916749
115retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.61513808
116histone demethylation (GO:0016577)2.61008346
117protein localization to endosome (GO:0036010)2.60798980
118embryonic process involved in female pregnancy (GO:0060136)2.59753285
119maturation of SSU-rRNA (GO:0030490)2.59647970
120histone H3-K9 methylation (GO:0051567)2.59293362
121RNA export from nucleus (GO:0006405)2.58938692
122paraxial mesoderm development (GO:0048339)2.56815566
1233-UTR-mediated mRNA stabilization (GO:0070935)2.56474203
124regulation of nuclease activity (GO:0032069)2.56229144
125regulation of histone methylation (GO:0031060)2.55438728
126regulation of nucleobase-containing compound transport (GO:0032239)2.55405093
127somatic hypermutation of immunoglobulin genes (GO:0016446)2.54760615
128somatic diversification of immune receptors via somatic mutation (GO:0002566)2.54760615
129ATP-dependent chromatin remodeling (GO:0043044)2.54657454
130endoplasmic reticulum unfolded protein response (GO:0030968)2.54657240
131nucleic acid transport (GO:0050657)2.53643533
132RNA transport (GO:0050658)2.53643533
133establishment of RNA localization (GO:0051236)2.53643533
134positive regulation of chromosome segregation (GO:0051984)2.52040106
135cellular hyperosmotic response (GO:0071474)2.51892979
136mRNA export from nucleus (GO:0006406)2.51791385
137mRNA splicing, via spliceosome (GO:0000398)2.51344665
138RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.51344665
139IMP metabolic process (GO:0046040)2.51169725
140ER-nucleus signaling pathway (GO:0006984)2.51136878
141protein localization to microtubule (GO:0035372)2.50732416
142microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.50398439
143regulation of histone H3-K4 methylation (GO:0051569)2.50187509
144maternal placenta development (GO:0001893)2.49565290
145positive regulation of cell cycle checkpoint (GO:1901978)2.49438924
146positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.49140159
147mannose metabolic process (GO:0006013)2.49096957
148vesicle coating (GO:0006901)2.48770825
149positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.46178722
150DNA synthesis involved in DNA repair (GO:0000731)2.45306645
151histone H2B ubiquitination (GO:0033523)2.44149464
152protein demethylation (GO:0006482)2.41682905
153protein dealkylation (GO:0008214)2.41682905
154regulation of RNA stability (GO:0043487)2.41357968
155DNA packaging (GO:0006323)2.39753913
156convergent extension (GO:0060026)2.39571545

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.95992690
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.55364129
3EGR1_19374776_ChIP-ChIP_THP-1_Human5.22197517
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.63119366
5MYC_22102868_ChIP-Seq_BL_Human3.28356625
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.22561994
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.06991566
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.04454130
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.02695449
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.71683626
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61738568
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.58898425
13* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35693599
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.20386121
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.11527012
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.08002366
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.97886218
18RBPJ_22232070_ChIP-Seq_NCS_Mouse1.93409044
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.89833103
20CIITA_25753668_ChIP-Seq_RAJI_Human1.86319838
21ZNF263_19887448_ChIP-Seq_K562_Human1.85608112
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80928612
23ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.77078680
24TCF7_22412390_ChIP-Seq_EML_Mouse1.74809608
25CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.73744682
26* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72529617
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.71914502
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.66948309
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66183759
30SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.65210861
31RACK7_27058665_Chip-Seq_MCF-7_Human1.63660060
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63363270
33KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.62598516
34XRN2_22483619_ChIP-Seq_HELA_Human1.62254537
35AR_21909140_ChIP-Seq_LNCAP_Human1.61727752
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61585781
37SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.60438210
38P300_27058665_Chip-Seq_ZR-75-30cells_Human1.57471959
39TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.55107539
40PKCTHETA_26484144_Chip-Seq_BREAST_Human1.54510457
41* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52721488
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52236507
43RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49398698
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.48968945
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.47359355
46* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.45185880
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.44853754
48ZFP281_27345836_Chip-Seq_ESCs_Mouse1.43858343
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42913128
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.41380147
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40192840
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38445570
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38253272
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37295351
55TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36906709
56KDM5A_27292631_Chip-Seq_BREAST_Human1.36809064
57CLOCK_20551151_ChIP-Seq_293T_Human1.35971738
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35350957
59KDM2B_26808549_Chip-Seq_DND41_Human1.35287423
60KDM2B_26808549_Chip-Seq_K562_Human1.33907096
61VDR_21846776_ChIP-Seq_THP-1_Human1.33573449
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33308362
63HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32998553
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32583525
65* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30550414
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29451540
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29402023
68TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26050339
69LXR_22292898_ChIP-Seq_THP-1_Human1.25921603
70RUNX1_27514584_Chip-Seq_MCF-7_Human1.25461023
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23395210
72ATF3_27146783_Chip-Seq_COLON_Human1.23264743
73* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23050603
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.22711499
75SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22160995
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21887776
77FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.21884891
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20993866
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.20609462
80* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.19909263
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18578847
82NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.18337747
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.18021449
84KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.18012359
85KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.18012359
86KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.18012359
87CHD1_26751641_Chip-Seq_LNCaP_Human1.17938408
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17677946
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17308389
90* UTX_26944678_Chip-Seq_JUKART_Human1.17194273
91* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16775588
92ELK1_19687146_ChIP-ChIP_HELA_Human1.16165879
93SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.15930155
94* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15329758
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15120472
96ESR1_21235772_ChIP-Seq_MCF-7_Human1.14417032
97SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14001789
98TFEB_21752829_ChIP-Seq_HELA_Human1.12741202
99SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11440766
100TTF2_22483619_ChIP-Seq_HELA_Human1.10777408
101NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09677034
102SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07377105
103STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06246940
104UBF1/2_26484160_Chip-Seq_HMECs_Human1.05151912
105* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04908632
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04825200
107WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04256487
108* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04209796
109NCOR1_26117541_ChIP-Seq_K562_Human1.03437557
110TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02308441
111TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01950764
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01142870
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01101478
114MYC_18358816_ChIP-ChIP_MESCs_Mouse1.00246624
115STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00197228
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99379275
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98678731
118KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98523418
119* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98325799
120EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97797341
121ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97237481
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97113395
123NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96563703
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95938311
125TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95688747
126FOXP3_21729870_ChIP-Seq_TREG_Human0.94347604
127CREB1_26743006_Chip-Seq_LNCaP_Human0.94335785
128EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93568103
129* GATA6_25053715_ChIP-Seq_YYC3_Human0.93445339
130MAF_26560356_Chip-Seq_TH1_Human0.93431220
131SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92683252
132VDR_23849224_ChIP-Seq_CD4+_Human0.92577916
133KDM2B_26808549_Chip-Seq_JURKAT_Human0.91570679
134FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89825310
135HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.89781541
136KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88866764
137* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.88520999
138NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86907997
139MYB_26560356_Chip-Seq_TH2_Human0.86858707
140FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86231471
141MYB_26560356_Chip-Seq_TH1_Human0.85853953
142SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85509848
143NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.84881838

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.49119342
2MP0010094_abnormal_chromosome_stability3.13667864
3MP0005076_abnormal_cell_differentiation3.07525955
4MP0000569_abnormal_digit_pigmentation2.99445734
5MP0003111_abnormal_nucleus_morphology2.94875820
6MP0003077_abnormal_cell_cycle2.75688600
7MP0003123_paternal_imprinting2.70858660
8MP0003705_abnormal_hypodermis_morpholog2.69452015
9MP0002877_abnormal_melanocyte_morpholog2.69111174
10MP0003693_abnormal_embryo_hatching2.55038351
11MP0003121_genomic_imprinting2.41825820
12MP0005451_abnormal_body_composition2.32149234
13MP0004957_abnormal_blastocyst_morpholog2.31161909
14MP0003787_abnormal_imprinting2.30964291
15MP0008438_abnormal_cutaneous_collagen2.27059612
16MP0008057_abnormal_DNA_replication2.23878907
17MP0004185_abnormal_adipocyte_glucose2.14788361
18MP0005409_darkened_coat_color2.12331223
19MP0010234_abnormal_vibrissa_follicle2.10003998
20MP0008007_abnormal_cellular_replicative2.09857272
21MP0010307_abnormal_tumor_latency2.02658423
22MP0008058_abnormal_DNA_repair2.01731796
23MP0000350_abnormal_cell_proliferation2.00359646
24MP0004808_abnormal_hematopoietic_stem2.00082040
25MP0003890_abnormal_embryonic-extraembry1.94727729
26MP0003567_abnormal_fetal_cardiomyocyte1.92559278
27MP0009278_abnormal_bone_marrow1.92022899
28MP0001730_embryonic_growth_arrest1.90880122
29MP0004197_abnormal_fetal_growth/weight/1.87925303
30MP0008877_abnormal_DNA_methylation1.81065160
31MP0000537_abnormal_urethra_morphology1.80654119
32MP0002084_abnormal_developmental_patter1.77022515
33MP0002396_abnormal_hematopoietic_system1.66619308
34MP0002009_preneoplasia1.66079050
35MP0005380_embryogenesis_phenotype1.65486594
36MP0001672_abnormal_embryogenesis/_devel1.65486594
37MP0010030_abnormal_orbit_morphology1.59426554
38MP0002088_abnormal_embryonic_growth/wei1.56689022
39MP0002089_abnormal_postnatal_growth/wei1.56497055
40MP0003984_embryonic_growth_retardation1.55157580
41MP0002085_abnormal_embryonic_tissue1.53414068
42MP0003941_abnormal_skin_development1.52980989
43MP0002086_abnormal_extraembryonic_tissu1.52884062
44MP0001697_abnormal_embryo_size1.52820324
45MP0005257_abnormal_intraocular_pressure1.52562461
46MP0004272_abnormal_basement_membrane1.50903460
47MP0001293_anophthalmia1.42536747
48MP0003453_abnormal_keratinocyte_physiol1.40224301
49MP0003300_gastrointestinal_ulcer1.38942218
50MP0002080_prenatal_lethality1.38880183
51MP0005623_abnormal_meninges_morphology1.38564756
52MP0003119_abnormal_digestive_system1.36288492
53MP0002060_abnormal_skin_morphology1.35393830
54MP0008961_abnormal_basal_metabolism1.33723679
55MP0005666_abnormal_adipose_tissue1.31435132
56MP0005058_abnormal_lysosome_morphology1.30911571
57MP0008260_abnormal_autophagy1.30503130
58MP0002796_impaired_skin_barrier1.27567561
59MP0003763_abnormal_thymus_physiology1.27268025
60MP0005187_abnormal_penis_morphology1.25764847
61MP0003122_maternal_imprinting1.25675813
62MP0000428_abnormal_craniofacial_morphol1.23452883
63MP0009703_decreased_birth_body1.22088318
64MP0001661_extended_life_span1.20334344
65MP0001849_ear_inflammation1.18582978
66MP0003566_abnormal_cell_adhesion1.18132763
67MP0010630_abnormal_cardiac_muscle1.13949218
68MP0000566_synostosis1.13113866
69MP0000703_abnormal_thymus_morphology1.12943236
70MP0004264_abnormal_extraembryonic_tissu1.12457690
71MP0001348_abnormal_lacrimal_gland1.12255147
72MP0000733_abnormal_muscle_development1.11682250
73MP0003935_abnormal_craniofacial_develop1.10804531
74MP0000003_abnormal_adipose_tissue1.09654011
75MP0005375_adipose_tissue_phenotype1.07177396
76MP0004233_abnormal_muscle_weight1.06872189
77MP0002092_abnormal_eye_morphology1.06549747
78MP0002697_abnormal_eye_size1.06210150
79MP0001545_abnormal_hematopoietic_system1.05898186
80MP0005397_hematopoietic_system_phenotyp1.05898186
81MP0009053_abnormal_anal_canal1.05894610
82MP0005501_abnormal_skin_physiology1.05002683
83MP0004858_abnormal_nervous_system1.04056656
84MP0000313_abnormal_cell_death1.02763615
85MP0009672_abnormal_birth_weight1.02061192
86MP0003115_abnormal_respiratory_system1.01839537
87MP0003091_abnormal_cell_migration1.00416652
88MP0005248_abnormal_Harderian_gland0.98431777
89MP0002925_abnormal_cardiovascular_devel0.97776174
90MP0008932_abnormal_embryonic_tissue0.96140311
91MP0008770_decreased_survivor_rate0.95981003
92MP0000490_abnormal_crypts_of0.95361318
93MP0005023_abnormal_wound_healing0.94296110
94MP0003861_abnormal_nervous_system0.93928030
95MP0006138_congestive_heart_failure0.93877718
96MP0003786_premature_aging0.92854903
97MP0002653_abnormal_ependyma_morphology0.91107430
98MP0002398_abnormal_bone_marrow0.90123793
99MP0000371_diluted_coat_color0.89985032
100MP0000516_abnormal_urinary_system0.89865752
101MP0005367_renal/urinary_system_phenotyp0.89865752
102MP0000579_abnormal_nail_morphology0.89689418
103MP0004087_abnormal_muscle_fiber0.88548094
104MP0001286_abnormal_eye_development0.87099022
105MP0003283_abnormal_digestive_organ0.87076205
106MP0005275_abnormal_skin_tensile0.86995614
107MP0001915_intracranial_hemorrhage0.86934796
108MP0002896_abnormal_bone_mineralization0.86354477
109MP0010678_abnormal_skin_adnexa0.86232110
110MP0000377_abnormal_hair_follicle0.86222778
111MP0003385_abnormal_body_wall0.85361975
112MP0006054_spinal_hemorrhage0.85233973
113MP0008789_abnormal_olfactory_epithelium0.85101910
114MP0003937_abnormal_limbs/digits/tail_de0.84864182
115MP0006292_abnormal_olfactory_placode0.84590606
116MP0002019_abnormal_tumor_incidence0.83671742
117MP0004782_abnormal_surfactant_physiolog0.83633887
118MP0003942_abnormal_urinary_system0.82649114
119MP0003868_abnormal_feces_composition0.81936820
120MP0000762_abnormal_tongue_morphology0.81024505
121MP0002108_abnormal_muscle_morphology0.80494334
122MP0003172_abnormal_lysosome_physiology0.80105322
123MP0005621_abnormal_cell_physiology0.79914015
124MP0000678_abnormal_parathyroid_gland0.79633671
125MP0005394_taste/olfaction_phenotype0.79057729
126MP0005499_abnormal_olfactory_system0.79057729
127MP0005384_cellular_phenotype0.78335895
128MP0006072_abnormal_retinal_apoptosis0.77058602
129MP0003943_abnormal_hepatobiliary_system0.76711501
130MP0001216_abnormal_epidermal_layer0.75994533
131MP0000627_abnormal_mammary_gland0.75684371
132MP0002166_altered_tumor_susceptibility0.74867626
133MP0001346_abnormal_lacrimal_gland0.74712799
134MP0000432_abnormal_head_morphology0.74603596
135MP0005503_abnormal_tendon_morphology0.73334503
136MP0002114_abnormal_axial_skeleton0.72502969
137MP0002081_perinatal_lethality0.72486586
138MP0000747_muscle_weakness0.71746862
139MP0000534_abnormal_ureter_morphology0.70005916
140MP0000266_abnormal_heart_morphology0.69499493
141MP0002111_abnormal_tail_morphology0.69121718
142MP0002075_abnormal_coat/hair_pigmentati0.67670293

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.83119329
2Volvulus (HP:0002580)3.71180549
3Colon cancer (HP:0003003)3.65873064
4Asymmetry of the thorax (HP:0001555)3.35852043
5Protrusio acetabuli (HP:0003179)3.24626012
6Abnormality of the astrocytes (HP:0100707)3.13330909
7Astrocytoma (HP:0009592)3.13330909
8Short 4th metacarpal (HP:0010044)2.97170423
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.97170423
10Hyperacusis (HP:0010780)2.83342886
11Medulloblastoma (HP:0002885)2.82122364
12Premature rupture of membranes (HP:0001788)2.75047151
13Increased nuchal translucency (HP:0010880)2.65998782
14Flat acetabular roof (HP:0003180)2.59547114
15Insomnia (HP:0100785)2.52590310
16Glioma (HP:0009733)2.50991250
17Ulnar bowing (HP:0003031)2.46572458
18Enlarged penis (HP:0000040)2.45662416
19Bowel diverticulosis (HP:0005222)2.44022557
20Gastrointestinal carcinoma (HP:0002672)2.43132933
21Malignant gastrointestinal tract tumors (HP:0006749)2.43132933
22Abnormality of the fingertips (HP:0001211)2.39251510
23Macroorchidism (HP:0000053)2.35911791
24Renal duplication (HP:0000075)2.34867283
25Deviation of the thumb (HP:0009603)2.34160935
26Elfin facies (HP:0004428)2.32799928
27Proximal placement of thumb (HP:0009623)2.31705329
28Pelvic girdle muscle weakness (HP:0003749)2.25622267
29Arterial tortuosity (HP:0005116)2.23240597
30Spinal cord lesions (HP:0100561)2.22957494
31Syringomyelia (HP:0003396)2.22957494
32Long eyelashes (HP:0000527)2.22365352
33Missing ribs (HP:0000921)2.19669118
34Cutaneous melanoma (HP:0012056)2.19368866
35Overlapping toe (HP:0001845)2.18760276
36Neoplasm of the oral cavity (HP:0100649)2.18030128
37Abnormality of the lower motor neuron (HP:0002366)2.16727428
38Basal cell carcinoma (HP:0002671)2.16299933
39Increased density of long bones (HP:0006392)2.15809202
40Dysmetric saccades (HP:0000641)2.15771506
41Biliary tract neoplasm (HP:0100574)2.15759517
42Back pain (HP:0003418)2.15363455
43Abnormality of the 4th metacarpal (HP:0010012)2.14842655
44Subacute progressive viral hepatitis (HP:0006572)2.11811905
45Heterotopia (HP:0002282)2.11449039
46Disproportionate tall stature (HP:0001519)2.11241003
47Obsessive-compulsive behavior (HP:0000722)2.09906709
48Broad palm (HP:0001169)2.08419331
49Selective tooth agenesis (HP:0001592)2.08302291
50Agnosia (HP:0010524)2.06369668
51Renovascular hypertension (HP:0100817)2.05900992
52Abnormality of the distal phalanx of the thumb (HP:0009617)2.04087652
53Truncal obesity (HP:0001956)2.02679160
54Shoulder girdle muscle weakness (HP:0003547)2.02645378
55Hand muscle atrophy (HP:0009130)2.02262633
56Obstructive sleep apnea (HP:0002870)2.01509461
57Cerebral aneurysm (HP:0004944)2.00725975
58Broad face (HP:0000283)2.00535317
59Vascular tortuosity (HP:0004948)2.00078945
60Deep venous thrombosis (HP:0002625)2.00016994
61Pointed chin (HP:0000307)1.99916976
62Mitral valve prolapse (HP:0001634)1.98880305
63Shallow orbits (HP:0000586)1.97348440
64Advanced eruption of teeth (HP:0006288)1.96837256
65Vertebral arch anomaly (HP:0008438)1.94225192
66Rhabdomyosarcoma (HP:0002859)1.93936833
67Trigonocephaly (HP:0000243)1.93759825
68Urethral obstruction (HP:0000796)1.93198514
69Dislocated radial head (HP:0003083)1.91742617
70Abnormality of the musculature of the pelvis (HP:0001469)1.91736458
71Abnormality of the hip-girdle musculature (HP:0001445)1.91736458
72Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.90006253
73Sparse lateral eyebrow (HP:0005338)1.89261803
74Limited elbow extension (HP:0001377)1.87574016
75Amaurosis fugax (HP:0100576)1.87136528
76Cutis marmorata (HP:0000965)1.86894034
77Abnormality of the calcaneus (HP:0008364)1.86887262
78Abnormal number of incisors (HP:0011064)1.86032169
79Termporal pattern (HP:0011008)1.84693582
80Insidious onset (HP:0003587)1.84693582
81Arnold-Chiari malformation (HP:0002308)1.84509265
82Skin tags (HP:0010609)1.83937800
83Absent frontal sinuses (HP:0002688)1.83452406
84Bladder diverticulum (HP:0000015)1.82916216
85Aneurysm (HP:0002617)1.81831188
86Overriding aorta (HP:0002623)1.81446721
87Chromosomal breakage induced by crosslinking agents (HP:0003221)1.81440360
88Long palpebral fissure (HP:0000637)1.80582569
89Natal tooth (HP:0000695)1.79988142
90Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.78665511
91Relative macrocephaly (HP:0004482)1.77407044
92Chromsome breakage (HP:0040012)1.77092279
93Thin ribs (HP:0000883)1.77000448
94Abnormality of the radial head (HP:0003995)1.76585615
95Abnormality of the salivary glands (HP:0010286)1.76434849
96Patellar dislocation (HP:0002999)1.75930789
97Abnormality of oral frenula (HP:0000190)1.75330229
98Aortic aneurysm (HP:0004942)1.75156436
99Hematochezia (HP:0002573)1.74471665
100Cafe-au-lait spot (HP:0000957)1.74070657
101Myelodysplasia (HP:0002863)1.73777102
102Turricephaly (HP:0000262)1.73692210
103Transitional cell carcinoma of the bladder (HP:0006740)1.73237705
104Pseudobulbar signs (HP:0002200)1.72562722
105Aplasia/Hypoplasia of the sternum (HP:0006714)1.72350637
106Abnormality of the labia minora (HP:0012880)1.72019471
107High pitched voice (HP:0001620)1.71374637
108Ankyloglossia (HP:0010296)1.69896043
109Freckling (HP:0001480)1.69546523
110Abnormality of abdominal situs (HP:0011620)1.69416712
111Abdominal situs inversus (HP:0003363)1.69416712
112Neoplasm of striated muscle (HP:0009728)1.68801058
113Rectal prolapse (HP:0002035)1.68368298
114Uterine neoplasm (HP:0010784)1.67976502
115Metaphyseal cupping (HP:0003021)1.66976654
116Preauricular skin tag (HP:0000384)1.66584542
117Wormian bones (HP:0002645)1.65456178
118Flat cornea (HP:0007720)1.65432531
119Ankle contracture (HP:0006466)1.64614086
120Neoplasm of the small intestine (HP:0100833)1.63859818
121Broad thumb (HP:0011304)1.63731286
122Leiomyosarcoma (HP:0100243)1.63483575
123Uterine leiomyosarcoma (HP:0002891)1.63483575
124Progressive external ophthalmoplegia (HP:0000590)1.62391605
125Ectopic kidney (HP:0000086)1.62283678
126Deep philtrum (HP:0002002)1.62138858
127Abnormality of chromosome segregation (HP:0002916)1.61999804
128Vertebral compression fractures (HP:0002953)1.61668495
129Germ cell neoplasia (HP:0100728)1.61584695
130Biconcave vertebral bodies (HP:0004586)1.61329891
131Trismus (HP:0000211)1.60586032
132Smooth philtrum (HP:0000319)1.60079177
133Progressive muscle weakness (HP:0003323)1.59944459
134Osteolytic defects of the phalanges of the hand (HP:0009771)1.59698380
135Osteolytic defects of the hand bones (HP:0009699)1.59698380
136Sandal gap (HP:0001852)1.59479128
137Intestinal polyposis (HP:0200008)1.59085261
138Thick eyebrow (HP:0000574)1.58757307
139Hammertoe (HP:0001765)1.58369763
140Increased connective tissue (HP:0009025)1.57971108
141Skull defect (HP:0001362)1.57786165
142Abnormality of the acetabulum (HP:0003170)1.57684581
143Fragile skin (HP:0001030)1.57645538
144Abnormality of the thoracic spine (HP:0100711)1.57505673
145Abnormal ossification of hand bones (HP:0005921)1.57294802
14611 pairs of ribs (HP:0000878)1.56996777
147Intestinal polyp (HP:0005266)1.56980418
148Deep palmar crease (HP:0006191)1.56558954
149Upper limb amyotrophy (HP:0009129)1.56384766
150Supernumerary ribs (HP:0005815)1.55952615
151Sacral dimple (HP:0000960)1.54892373
152Amyotrophic lateral sclerosis (HP:0007354)1.54574774
153Dilatation of the ascending aorta (HP:0005111)1.54560743
154Papillary thyroid carcinoma (HP:0002895)1.54046994
155Abnormality of carpal bone ossification (HP:0006257)1.53895615
156Abnormality of chromosome stability (HP:0003220)1.53622295
157Blue sclerae (HP:0000592)1.53606192
158Nephroblastoma (Wilms tumor) (HP:0002667)1.53517263
159Facial hemangioma (HP:0000329)1.53279584
160Fibrous tissue neoplasm (HP:0012316)1.52998091
161Prominent nose (HP:0000448)1.52849422
162Distal upper limb amyotrophy (HP:0007149)1.52413602
163Cupped ribs (HP:0000887)1.51889475
164Renal cell carcinoma (HP:0005584)1.51753288

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.29569711
2MAP3K103.62695411
3EEF2K3.50554389
4CDC73.47909802
5PKN23.40309663
6SMG13.19263489
7ICK2.70770776
8TSSK62.54362938
9SRPK12.25990313
10NEK22.21411807
11ALK2.06722764
12BRD42.06527356
13NEK12.01547514
14PASK2.00815392
15PRPF4B2.00790781
16SIK11.98720454
17RPS6KB21.87384140
18TRIB31.87054364
19SCYL21.85085718
20ERBB31.60436546
21LATS11.60194849
22PDGFRA1.56445016
23ATR1.43305229
24TGFBR11.42744674
25TTK1.42179111
26CDK61.40913520
27PLK31.35095726
28MST1R1.34574588
29EIF2AK11.31814930
30MAP3K131.29553569
31MKNK11.29400689
32TTN1.29371132
33KSR21.28334844
34MET1.24163985
35CDK41.23781989
36MTOR1.23732945
37ERN11.22774577
38WEE11.22339248
39STK101.21854514
40PTK61.18342946
41CHEK11.16433223
42PLK11.16295609
43PTK21.16076548
44SIK21.13497411
45PAK41.12732065
46FLT31.10090423
47LRRK21.07143958
48NTRK11.05919015
49RIPK11.05464023
50ATM1.02626107
51* CDK20.94762110
52FGFR30.94201383
53CAMK1D0.93069638
54CDK70.91536664
55AURKB0.91160262
56CLK10.87439580
57STK30.87004173
58KSR10.86964600
59RPS6KA40.86639187
60DYRK30.85133982
61NEK90.84350314
62MKNK20.81420800
63AKT30.81397613
64MAP3K80.79293294
65MELK0.78829213
66CHEK20.77013587
67FGFR10.77000581
68FRK0.75537416
69* CDK10.74620231
70CDC42BPA0.73787872
71TAOK20.73472356
72PNCK0.72878635
73FGFR20.72223732
74CDK90.72032557
75MAPK110.71616296
76MAP4K10.71161107
77WNK10.67869012
78PRKDC0.64712754
79CSNK1E0.64581815
80NEK60.63944562
81IRAK30.63718767
82PAK20.63238601
83TRPM70.63120436
84MAP3K140.62118870
85PDGFRB0.61435147
86MAP3K90.61024588
87CHUK0.60059248
88PRKD30.58492838
89EPHA20.58155172
90PIM10.58034694
91BMX0.57740386
92* MAPK140.56431151
93DMPK0.54606241
94DAPK10.54103116
95YES10.52986537
96MARK20.52545771
97RET0.52114283
98CAMK1G0.51247314
99PDPK10.50030458
100LATS20.48815172
101DDR20.48364347
102NME20.48330798
103CSNK1D0.48286401
104MAPK80.48051119
105MAP3K20.47188205
106MAP2K20.46579493
107JAK30.46454425
108CSF1R0.44730523
109MAPK90.44432874
110ACVR1B0.44158578
111* GSK3B0.43109150
112NLK0.42941589
113GRK60.42157415
114ERBB40.41523941
115TYK20.39732003
116AKT20.39232253
117FGFR40.38680521
118RPS6KA20.38143128
119BRSK10.37838865
120SIK30.37706843
121BRSK20.37343649
122HCK0.37133715
123BRAF0.36445181
124STK40.35839037
125CSNK2A20.35408058
126MAPK10.35384817
127BUB10.34737904
128AKT10.34310756
129EGFR0.33962845
130RPS6KA10.33484225
131MAPK100.32326844
132SGK30.32249971
133DYRK1B0.31366466
134RPS6KB10.30995864
135MAP3K70.30508021
136TYRO30.29343167

Predicted pathways (KEGG)

RankGene SetZ-score
1* Spliceosome_Homo sapiens_hsa030402.28858753
2RNA transport_Homo sapiens_hsa030132.20368249
3Cell cycle_Homo sapiens_hsa041102.11446422
4Mismatch repair_Homo sapiens_hsa034302.09899826
5mRNA surveillance pathway_Homo sapiens_hsa030152.08411040
6DNA replication_Homo sapiens_hsa030302.07585960
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03993376
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88861511
9Colorectal cancer_Homo sapiens_hsa052101.77972748
10Chronic myeloid leukemia_Homo sapiens_hsa052201.68226845
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53188917
12One carbon pool by folate_Homo sapiens_hsa006701.53095636
13MicroRNAs in cancer_Homo sapiens_hsa052061.48071450
14Other glycan degradation_Homo sapiens_hsa005111.40973903
15Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.40758601
16Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.40710323
17Viral carcinogenesis_Homo sapiens_hsa052031.39573710
18mTOR signaling pathway_Homo sapiens_hsa041501.38147545
19Antigen processing and presentation_Homo sapiens_hsa046121.35823092
20Base excision repair_Homo sapiens_hsa034101.31136128
21Adherens junction_Homo sapiens_hsa045201.30554869
22RNA degradation_Homo sapiens_hsa030181.29805765
23HTLV-I infection_Homo sapiens_hsa051661.29094277
24Endometrial cancer_Homo sapiens_hsa052131.28696411
25Fanconi anemia pathway_Homo sapiens_hsa034601.23556071
26Oocyte meiosis_Homo sapiens_hsa041141.22380600
27Nucleotide excision repair_Homo sapiens_hsa034201.19181569
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16672649
29Notch signaling pathway_Homo sapiens_hsa043301.15739739
30p53 signaling pathway_Homo sapiens_hsa041151.14872652
31Non-small cell lung cancer_Homo sapiens_hsa052231.14663820
32Small cell lung cancer_Homo sapiens_hsa052221.14348565
33Choline metabolism in cancer_Homo sapiens_hsa052311.13604517
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.10288473
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09858107
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.08913560
37Inositol phosphate metabolism_Homo sapiens_hsa005621.08339912
38Hippo signaling pathway_Homo sapiens_hsa043901.06260516
39Non-homologous end-joining_Homo sapiens_hsa034501.04896816
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04756669
41Proteoglycans in cancer_Homo sapiens_hsa052051.03983648
42Thyroid cancer_Homo sapiens_hsa052161.03760468
43Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02787360
44Prion diseases_Homo sapiens_hsa050201.00817689
45Pancreatic cancer_Homo sapiens_hsa052121.00471024
46T cell receptor signaling pathway_Homo sapiens_hsa046601.00469635
47Epstein-Barr virus infection_Homo sapiens_hsa051690.99531824
48Glioma_Homo sapiens_hsa052140.99378845
49Hepatitis B_Homo sapiens_hsa051610.98866338
50Systemic lupus erythematosus_Homo sapiens_hsa053220.95376663
51Lysine degradation_Homo sapiens_hsa003100.94854986
52Pentose phosphate pathway_Homo sapiens_hsa000300.94063207
53Basal cell carcinoma_Homo sapiens_hsa052170.92724312
54Acute myeloid leukemia_Homo sapiens_hsa052210.92385788
55Herpes simplex infection_Homo sapiens_hsa051680.91568739
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90974653
57ECM-receptor interaction_Homo sapiens_hsa045120.90967881
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90391993
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.90159792
60AMPK signaling pathway_Homo sapiens_hsa041520.90139550
61Estrogen signaling pathway_Homo sapiens_hsa049150.89805083
62Viral myocarditis_Homo sapiens_hsa054160.89677573
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88894293
64Biosynthesis of amino acids_Homo sapiens_hsa012300.88735183
65Homologous recombination_Homo sapiens_hsa034400.88416528
66Alcoholism_Homo sapiens_hsa050340.87296238
67Prostate cancer_Homo sapiens_hsa052150.85393777
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85271285
69B cell receptor signaling pathway_Homo sapiens_hsa046620.85171216
70Focal adhesion_Homo sapiens_hsa045100.84451354
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84245563
72Type II diabetes mellitus_Homo sapiens_hsa049300.83386275
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83156829
74Amoebiasis_Homo sapiens_hsa051460.82883832
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82139290
76FoxO signaling pathway_Homo sapiens_hsa040680.81767472
77Wnt signaling pathway_Homo sapiens_hsa043100.80853973
78Hepatitis C_Homo sapiens_hsa051600.80783414
79Primary immunodeficiency_Homo sapiens_hsa053400.78641207
80Pathways in cancer_Homo sapiens_hsa052000.77818699
81HIF-1 signaling pathway_Homo sapiens_hsa040660.75383097
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73584642
83Fructose and mannose metabolism_Homo sapiens_hsa000510.73148984
84Prolactin signaling pathway_Homo sapiens_hsa049170.71978665
85Platelet activation_Homo sapiens_hsa046110.71899781
86GnRH signaling pathway_Homo sapiens_hsa049120.71872216
87VEGF signaling pathway_Homo sapiens_hsa043700.71768925
88TGF-beta signaling pathway_Homo sapiens_hsa043500.71606628
89Measles_Homo sapiens_hsa051620.71473985
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71461482
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.70877103
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70797122
93Apoptosis_Homo sapiens_hsa042100.70337646
94Toxoplasmosis_Homo sapiens_hsa051450.67847876
95ErbB signaling pathway_Homo sapiens_hsa040120.67624066
96Thyroid hormone synthesis_Homo sapiens_hsa049180.67172578
97Glucagon signaling pathway_Homo sapiens_hsa049220.66300960
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66251289
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66035549
100Renal cell carcinoma_Homo sapiens_hsa052110.64980255
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62586336
102Shigellosis_Homo sapiens_hsa051310.61562874
103Influenza A_Homo sapiens_hsa051640.60978938
104Insulin signaling pathway_Homo sapiens_hsa049100.59936695
105Osteoclast differentiation_Homo sapiens_hsa043800.59172756
106Hedgehog signaling pathway_Homo sapiens_hsa043400.58586987
107Long-term potentiation_Homo sapiens_hsa047200.58581730
108Rap1 signaling pathway_Homo sapiens_hsa040150.58483994
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.58048718
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57229790
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56828094
112Bladder cancer_Homo sapiens_hsa052190.56166690
113Melanoma_Homo sapiens_hsa052180.55847741
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54544474
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54280995
116NF-kappa B signaling pathway_Homo sapiens_hsa040640.54186788
117Tight junction_Homo sapiens_hsa045300.54097687
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54050563
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53068859
120MAPK signaling pathway_Homo sapiens_hsa040100.52875058
121Insulin resistance_Homo sapiens_hsa049310.52664376
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52517169
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.52373083
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52153704
125Melanogenesis_Homo sapiens_hsa049160.52071653
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51503558
127Gap junction_Homo sapiens_hsa045400.51443293
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49239739

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