DDX27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.91111397
2DNA replication initiation (GO:0006270)4.55832087
3maturation of SSU-rRNA (GO:0030490)4.55121677
4protein localization to kinetochore (GO:0034501)4.48636129
5DNA strand elongation involved in DNA replication (GO:0006271)4.47552240
6rRNA modification (GO:0000154)4.43673414
7chromosome condensation (GO:0030261)4.37724407
8regulation of translational termination (GO:0006449)4.33689410
9nuclear pore organization (GO:0006999)4.28075115
10DNA strand elongation (GO:0022616)4.27368266
11rRNA methylation (GO:0031167)4.25252624
12nucleobase biosynthetic process (GO:0046112)4.24322598
13formation of translation preinitiation complex (GO:0001731)4.21418897
14nuclear pore complex assembly (GO:0051292)4.19744305
15IMP biosynthetic process (GO:0006188)4.13584200
16folic acid-containing compound biosynthetic process (GO:0009396)4.12128869
17telomere maintenance via semi-conservative replication (GO:0032201)4.08372224
18ribosomal small subunit assembly (GO:0000028)4.07836360
19DNA packaging (GO:0006323)3.98393291
20mitotic metaphase plate congression (GO:0007080)3.95416615
21DNA replication checkpoint (GO:0000076)3.92879616
22mitotic nuclear envelope disassembly (GO:0007077)3.92665091
23ribosome biogenesis (GO:0042254)3.91427164
24protein localization to chromosome, centromeric region (GO:0071459)3.91170973
25ribosome assembly (GO:0042255)3.82582928
26purine nucleobase biosynthetic process (GO:0009113)3.80306906
27viral transcription (GO:0019083)3.75774666
28ribonucleoprotein complex biogenesis (GO:0022613)3.74116175
29spliceosomal tri-snRNP complex assembly (GO:0000244)3.72304029
30translational termination (GO:0006415)3.70774309
31ribosomal small subunit biogenesis (GO:0042274)3.65009554
32telomere maintenance via recombination (GO:0000722)3.63366318
33DNA replication-dependent nucleosome assembly (GO:0006335)3.63031222
34DNA replication-dependent nucleosome organization (GO:0034723)3.63031222
35nuclear envelope disassembly (GO:0051081)3.61985296
36membrane disassembly (GO:0030397)3.61985296
37ribosomal large subunit biogenesis (GO:0042273)3.60240779
38IMP metabolic process (GO:0046040)3.58862239
39mitotic recombination (GO:0006312)3.57982801
40kinetochore organization (GO:0051383)3.53843968
41DNA duplex unwinding (GO:0032508)3.49712915
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.46960948
43DNA geometric change (GO:0032392)3.46714369
44translational initiation (GO:0006413)3.46158303
45metaphase plate congression (GO:0051310)3.43741552
46rRNA processing (GO:0006364)3.42796227
47translational elongation (GO:0006414)3.40857436
48regulation of mitochondrial translation (GO:0070129)3.40066452
49telomere maintenance via telomere lengthening (GO:0010833)3.37237750
50mitotic sister chromatid segregation (GO:0000070)3.34761900
51rRNA metabolic process (GO:0016072)3.32811260
52chromatin remodeling at centromere (GO:0031055)3.32206166
53nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.32142287
54cellular component biogenesis (GO:0044085)3.30093380
55mitotic chromosome condensation (GO:0007076)3.29656642
56regulation of centriole replication (GO:0046599)3.29627148
57pore complex assembly (GO:0046931)3.29330663
58CENP-A containing nucleosome assembly (GO:0034080)3.27454040
59viral mRNA export from host cell nucleus (GO:0046784)3.22776829
60regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.22444789
61proteasome assembly (GO:0043248)3.21691272
62negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.20468727
63somatic diversification of immune receptors via somatic mutation (GO:0002566)3.19518882
64somatic hypermutation of immunoglobulin genes (GO:0016446)3.19518882
65DNA deamination (GO:0045006)3.18366365
66nucleotide-excision repair, DNA gap filling (GO:0006297)3.17607021
67regulation of nuclear cell cycle DNA replication (GO:0033262)3.17282072
68kinetochore assembly (GO:0051382)3.17234228
69DNA replication-independent nucleosome assembly (GO:0006336)3.15601086
70DNA replication-independent nucleosome organization (GO:0034724)3.15601086
71regulation of spindle organization (GO:0090224)3.14465875
72sister chromatid segregation (GO:0000819)3.13226127
73positive regulation of chromosome segregation (GO:0051984)3.10549225
74pseudouridine synthesis (GO:0001522)3.09728923
75tRNA methylation (GO:0030488)3.09458157
76spliceosomal snRNP assembly (GO:0000387)3.08151747
77negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04633942
78transcription from mitochondrial promoter (GO:0006390)3.04337458
79maturation of 5.8S rRNA (GO:0000460)3.04098875
80establishment of chromosome localization (GO:0051303)3.04027143
81negative regulation of RNA splicing (GO:0033119)3.01102707
82SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.00339020
83regulation of histone H3-K9 methylation (GO:0051570)2.99765500
84attachment of spindle microtubules to kinetochore (GO:0008608)2.98530625
85protein K6-linked ubiquitination (GO:0085020)2.96500727
86heterochromatin organization (GO:0070828)2.95871848
87regulation of histone H3-K27 methylation (GO:0061085)2.95015775
88cellular protein complex disassembly (GO:0043624)2.94522210
89mitochondrial RNA metabolic process (GO:0000959)2.94298685
90mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.93701907
91regulation of helicase activity (GO:0051095)2.92461331
92regulation of posttranscriptional gene silencing (GO:0060147)2.91719322
93regulation of gene silencing by miRNA (GO:0060964)2.91719322
94regulation of gene silencing by RNA (GO:0060966)2.91719322
95protein targeting to ER (GO:0045047)2.91570397
96cotranslational protein targeting to membrane (GO:0006613)2.91182708
97chromatin assembly or disassembly (GO:0006333)2.90764109
98translation (GO:0006412)2.90755952
99meiotic chromosome segregation (GO:0045132)2.90092388
100transcription-coupled nucleotide-excision repair (GO:0006283)2.89163763
101viral life cycle (GO:0019058)2.88967619
102anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.88886514
103RNA splicing, via transesterification reactions (GO:0000375)2.88472895
104RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.87123164
105mRNA splicing, via spliceosome (GO:0000398)2.87123164
106negative regulation of mRNA processing (GO:0050686)2.86556109
107regulation of centrosome cycle (GO:0046605)2.85540693
108DNA conformation change (GO:0071103)2.84968867
109establishment of integrated proviral latency (GO:0075713)2.83119655
110regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.83090308
111protein localization to endoplasmic reticulum (GO:0070972)2.82743360
112regulation of spindle checkpoint (GO:0090231)2.82381561
113negative regulation of ligase activity (GO:0051352)2.82283366
114negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.82283366
115negative regulation of mRNA metabolic process (GO:1903312)2.82160713
116regulation of translational fidelity (GO:0006450)2.82027218
117peptidyl-arginine omega-N-methylation (GO:0035247)2.81647468
118ncRNA processing (GO:0034470)2.80328241
119positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.79725283
120telomere organization (GO:0032200)2.79618744
121telomere maintenance (GO:0000723)2.79487893
122histone exchange (GO:0043486)2.78552240
123protein localization to chromosome (GO:0034502)2.78309622
124nuclear envelope organization (GO:0006998)2.77646277
125nuclear-transcribed mRNA catabolic process (GO:0000956)2.77275097
126establishment of protein localization to endoplasmic reticulum (GO:0072599)2.76496393
127protein complex disassembly (GO:0043241)2.76177058
128negative regulation of histone methylation (GO:0031061)2.75948950
129maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.75373201
130termination of RNA polymerase II transcription (GO:0006369)2.75195208
131folic acid metabolic process (GO:0046655)2.74200317
132DNA-templated transcription, termination (GO:0006353)2.72927087
133ncRNA metabolic process (GO:0034660)2.68711474
134regulation of translational elongation (GO:0006448)2.64849602
135DNA topological change (GO:0006265)2.64330026

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.09089062
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.30334922
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.04766766
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.63922045
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.54249566
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.11629244
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.06332900
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80124634
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.67888316
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.63944820
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.56661417
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.52746375
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39541539
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.37430566
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30945234
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29224387
17* XRN2_22483619_ChIP-Seq_HELA_Human2.25626835
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.21909145
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18337296
20VDR_23849224_ChIP-Seq_CD4+_Human2.07136032
21MYC_22102868_ChIP-Seq_BL_Human2.03707184
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02314123
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.00378162
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98997061
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96575049
26AR_21909140_ChIP-Seq_LNCAP_Human1.94785351
27FOXP3_21729870_ChIP-Seq_TREG_Human1.88410495
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85597741
29* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85150406
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80087121
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79943801
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79921122
33DCP1A_22483619_ChIP-Seq_HELA_Human1.78358385
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78276531
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72172118
36TTF2_22483619_ChIP-Seq_HELA_Human1.71834229
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71740105
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71249097
39* GABP_19822575_ChIP-Seq_HepG2_Human1.65914000
40CIITA_25753668_ChIP-Seq_RAJI_Human1.65873847
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60732041
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60351321
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.56884503
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55718657
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55206771
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52542789
47* ELK1_19687146_ChIP-ChIP_HELA_Human1.49743263
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.46946508
49KDM5A_27292631_Chip-Seq_BREAST_Human1.46898239
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45779887
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.43216115
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42320262
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39882361
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38353179
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37397963
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.36686753
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.35828405
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34041631
59* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34009842
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31960348
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31069329
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30933544
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30053437
64KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.27746187
65KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.27746187
66KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.27746187
67VDR_21846776_ChIP-Seq_THP-1_Human1.27020627
68* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25642886
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20563043
70ZNF263_19887448_ChIP-Seq_K562_Human1.20347296
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20179507
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19633297
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19410435
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18154730
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15924178
76TFEB_21752829_ChIP-Seq_HELA_Human1.15656397
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13950865
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13201486
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11230100
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10209827
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10088154
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08288425
83* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02551603
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.02508794
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02314492
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00252961
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99362901
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96267700
89* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94810758
90SPI1_23547873_ChIP-Seq_NB4_Human0.93785569
91TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93211178
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93036115
93ATF3_27146783_Chip-Seq_COLON_Human0.92843975
94MYC_18940864_ChIP-ChIP_HL60_Human0.91112134
95FOXP1_21924763_ChIP-Seq_HESCs_Human0.90726296
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90199733
97* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90160826
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89975082
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88695313
100* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88610491
101TET1_21451524_ChIP-Seq_MESCs_Mouse0.88384789
102* ELF5_23300383_ChIP-Seq_T47D_Human0.87711367
103NANOG_21062744_ChIP-ChIP_HESCs_Human0.86456218
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86175229
105PKCTHETA_26484144_Chip-Seq_BREAST_Human0.85657975
106NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84103121
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84013472
108ELF1_20517297_ChIP-Seq_JURKAT_Human0.83479708
109HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81799926
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81627727
111NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.80422478
112P68_20966046_ChIP-Seq_HELA_Human0.79803972
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.78555822
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78383772
115OCT4_18692474_ChIP-Seq_MEFs_Mouse0.76428030
116NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.76255978
117MYB_26560356_Chip-Seq_TH1_Human0.75213987
118CHD1_26751641_Chip-Seq_LNCaP_Human0.74926793
119* ELK1_22589737_ChIP-Seq_MCF10A_Human0.73926628

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.02455489
2MP0008057_abnormal_DNA_replication4.50893863
3MP0010094_abnormal_chromosome_stability4.46938433
4MP0003111_abnormal_nucleus_morphology4.37272800
5MP0004957_abnormal_blastocyst_morpholog4.16414369
6MP0003077_abnormal_cell_cycle3.83081242
7MP0008058_abnormal_DNA_repair3.25662384
8MP0008007_abnormal_cellular_replicative2.70243446
9MP0002396_abnormal_hematopoietic_system2.62192463
10MP0010352_gastrointestinal_tract_polyps2.61011550
11MP0005410_abnormal_fertilization2.45867414
12MP0008932_abnormal_embryonic_tissue2.35237075
13MP0001730_embryonic_growth_arrest2.28800489
14MP0000350_abnormal_cell_proliferation2.27473272
15MP0010307_abnormal_tumor_latency2.06145253
16MP0003786_premature_aging1.98928595
17MP0002796_impaired_skin_barrier1.97259666
18MP0008877_abnormal_DNA_methylation1.97240555
19MP0000490_abnormal_crypts_of1.84966420
20MP0004264_abnormal_extraembryonic_tissu1.84401210
21MP0003123_paternal_imprinting1.78810718
22MP0001672_abnormal_embryogenesis/_devel1.75661577
23MP0005380_embryogenesis_phenotype1.75661577
24MP0003763_abnormal_thymus_physiology1.66707825
25MP0004808_abnormal_hematopoietic_stem1.62312161
26MP0001697_abnormal_embryo_size1.61854035
27MP0001873_stomach_inflammation1.60847477
28MP0005451_abnormal_body_composition1.58062912
29MP0003984_embryonic_growth_retardation1.57131867
30MP0006035_abnormal_mitochondrial_morpho1.56426112
31MP0002080_prenatal_lethality1.55999457
32MP0004197_abnormal_fetal_growth/weight/1.53088375
33MP0002088_abnormal_embryonic_growth/wei1.53054464
34MP0010234_abnormal_vibrissa_follicle1.51305228
35MP0002019_abnormal_tumor_incidence1.50502457
36MP0002085_abnormal_embryonic_tissue1.49901887
37MP0000313_abnormal_cell_death1.49308955
38MP0009333_abnormal_splenocyte_physiolog1.46985291
39MP0002084_abnormal_developmental_patter1.43995998
40MP0002086_abnormal_extraembryonic_tissu1.43029161
41MP0009697_abnormal_copulation1.41426202
42MP0005397_hematopoietic_system_phenotyp1.39604438
43MP0001545_abnormal_hematopoietic_system1.39604438
44MP0000703_abnormal_thymus_morphology1.37255482
45MP0000678_abnormal_parathyroid_gland1.35429893
46MP0005076_abnormal_cell_differentiation1.33908881
47MP0001881_abnormal_mammary_gland1.33185378
48MP0002398_abnormal_bone_marrow1.33135495
49MP0003718_maternal_effect1.31147859
50MP0001348_abnormal_lacrimal_gland1.27954226
51MP0002722_abnormal_immune_system1.23520855
52MP0000689_abnormal_spleen_morphology1.21652290
53MP0000627_abnormal_mammary_gland1.19123231
54MP0004233_abnormal_muscle_weight1.16447410
55MP0003567_abnormal_fetal_cardiomyocyte1.13335088
56MP0001216_abnormal_epidermal_layer1.12190288
57MP0005408_hypopigmentation1.11074980
58MP0001293_anophthalmia1.10783223
59MP0003950_abnormal_plasma_membrane1.09447193
60MP0002210_abnormal_sex_determination1.07505917
61MP0003806_abnormal_nucleotide_metabolis1.07142424
62MP0003698_abnormal_male_reproductive1.07089592
63MP0004185_abnormal_adipocyte_glucose1.06336266
64MP0009278_abnormal_bone_marrow1.04956727
65MP0002254_reproductive_system_inflammat1.03981405
66MP0006036_abnormal_mitochondrial_physio1.03916680
67MP0003121_genomic_imprinting1.02602173
68MP0002429_abnormal_blood_cell1.00301605
69MP0004782_abnormal_surfactant_physiolog0.99450949
70MP0002132_abnormal_respiratory_system0.96375508
71MP0002060_abnormal_skin_morphology0.95062656
72MP0004133_heterotaxia0.94495878
73MP0009379_abnormal_foot_pigmentation0.94185645
74MP0002098_abnormal_vibrissa_morphology0.93687977
75MP0001145_abnormal_male_reproductive0.93336725
76MP0000716_abnormal_immune_system0.91654636
77MP0000858_altered_metastatic_potential0.91609213
78MP0008260_abnormal_autophagy0.90181489
79MP0002111_abnormal_tail_morphology0.89736031
80MP0003566_abnormal_cell_adhesion0.89679115
81MP0005083_abnormal_biliary_tract0.89460413
82MP0003890_abnormal_embryonic-extraembry0.88516686
83MP0001800_abnormal_humoral_immune0.87568201
84MP0006292_abnormal_olfactory_placode0.87082388
85MP0001853_heart_inflammation0.85350936
86MP0005023_abnormal_wound_healing0.84895023
87MP0010771_integument_phenotype0.84850901
88MP0001727_abnormal_embryo_implantation0.83706872
89MP0000358_abnormal_cell_content/0.83504936
90MP0003119_abnormal_digestive_system0.81521486
91MP0000685_abnormal_immune_system0.80669527
92MP0005384_cellular_phenotype0.80652195
93MP0005621_abnormal_cell_physiology0.80090291
94MP0002161_abnormal_fertility/fecundity0.79703215
95MP0010030_abnormal_orbit_morphology0.79362367
96MP0002405_respiratory_system_inflammati0.79226201
97MP0009672_abnormal_birth_weight0.77820029
98MP0003315_abnormal_perineum_morphology0.77523561
99MP0001915_intracranial_hemorrhage0.77075624
100MP0001929_abnormal_gametogenesis0.76273923
101MP0000477_abnormal_intestine_morphology0.75839030
102MP0000653_abnormal_sex_gland0.75769129
103MP0005377_hearing/vestibular/ear_phenot0.73214299
104MP0003878_abnormal_ear_physiology0.73214299
105MP0002420_abnormal_adaptive_immunity0.72986816
106MP0002160_abnormal_reproductive_system0.71368227
107MP0000465_gastrointestinal_hemorrhage0.71330803
108MP0001819_abnormal_immune_cell0.71264152
109MP0000467_abnormal_esophagus_morphology0.70784634
110MP0002452_abnormal_antigen_presenting0.69842637
111MP0000377_abnormal_hair_follicle0.69639367
112MP0005310_abnormal_salivary_gland0.69307008
113MP0009703_decreased_birth_body0.68957850
114MP0002092_abnormal_eye_morphology0.68280441
115MP0002877_abnormal_melanocyte_morpholog0.67675223
116MP0000579_abnormal_nail_morphology0.66193454
117MP0003936_abnormal_reproductive_system0.66148478
118MP0003705_abnormal_hypodermis_morpholog0.65884782
119MP0002006_tumorigenesis0.65407150
120MP0001849_ear_inflammation0.65386635
121MP0002166_altered_tumor_susceptibility0.64802800
122MP0003937_abnormal_limbs/digits/tail_de0.64790951
123MP0002723_abnormal_immune_serum0.64308464
124MP0005501_abnormal_skin_physiology0.63897936
125MP0001119_abnormal_female_reproductive0.63574034
126MP0001835_abnormal_antigen_presentation0.63415396
127MP0010155_abnormal_intestine_physiology0.63348514
128MP0005075_abnormal_melanosome_morpholog0.63293383
129MP0004381_abnormal_hair_follicle0.62650558
130MP0001919_abnormal_reproductive_system0.62584498
131MP0002653_abnormal_ependyma_morphology0.62209825
132MP0000371_diluted_coat_color0.61656018
133MP0001186_pigmentation_phenotype0.61121242
134MP0005671_abnormal_response_to0.60891089
135MP0000428_abnormal_craniofacial_morphol0.60284184
136MP0003941_abnormal_skin_development0.60266459
137MP0003186_abnormal_redox_activity0.59701293
138MP0008770_decreased_survivor_rate0.59671987
139MP0003436_decreased_susceptibility_to0.59582862
140MP0003448_altered_tumor_morphology0.59554587

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.43231169
2Reticulocytopenia (HP:0001896)4.08064862
3Abnormality of cells of the erythroid lineage (HP:0012130)3.90904064
4Chromsome breakage (HP:0040012)3.84805140
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.71813499
6Abnormal number of erythroid precursors (HP:0012131)3.66445617
7Breast hypoplasia (HP:0003187)3.57775650
8Ependymoma (HP:0002888)3.55879077
9Progressive muscle weakness (HP:0003323)3.55698180
10Selective tooth agenesis (HP:0001592)3.35414312
11Microvesicular hepatic steatosis (HP:0001414)3.34506480
12Medulloblastoma (HP:0002885)3.10564883
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.07030236
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.07030236
15Patellar aplasia (HP:0006443)3.04696060
16Type I transferrin isoform profile (HP:0003642)2.91464275
17Abnormality of chromosome stability (HP:0003220)2.91192071
18Abnormality of the preputium (HP:0100587)2.89989732
19Abnormality of the anterior horn cell (HP:0006802)2.89331253
20Degeneration of anterior horn cells (HP:0002398)2.89331253
21Meckel diverticulum (HP:0002245)2.88671375
22Colon cancer (HP:0003003)2.86928301
23Aplasia/Hypoplasia of the patella (HP:0006498)2.86264183
24Absent thumb (HP:0009777)2.82231975
25Oral leukoplakia (HP:0002745)2.78302365
26Abnormality of the ileum (HP:0001549)2.77973256
27Myelodysplasia (HP:0002863)2.75233395
28Agnosia (HP:0010524)2.72822564
29Basal cell carcinoma (HP:0002671)2.69571320
30Abnormal mitochondria in muscle tissue (HP:0008316)2.68912173
31Carpal bone hypoplasia (HP:0001498)2.65497607
32Pallor (HP:0000980)2.64442681
33Macrocytic anemia (HP:0001972)2.61287818
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.59618133
35Rough bone trabeculation (HP:0100670)2.57544152
36Abnormal number of incisors (HP:0011064)2.55413300
37Absent radius (HP:0003974)2.55160689
3811 pairs of ribs (HP:0000878)2.50768975
39Impulsivity (HP:0100710)2.49102762
40Rhabdomyosarcoma (HP:0002859)2.48565897
41Acute necrotizing encephalopathy (HP:0006965)2.48475226
42Increased CSF lactate (HP:0002490)2.48038442
43Sparse eyelashes (HP:0000653)2.45679784
44Hepatocellular necrosis (HP:0001404)2.44070237
45Increased serum lactate (HP:0002151)2.44032477
46Squamous cell carcinoma (HP:0002860)2.42630554
47Abnormal protein glycosylation (HP:0012346)2.42226304
48Abnormal glycosylation (HP:0012345)2.42226304
49Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.42226304
50Abnormal protein N-linked glycosylation (HP:0012347)2.42226304
51Aplastic anemia (HP:0001915)2.41432606
52Increased hepatocellular lipid droplets (HP:0006565)2.40148713
53Proximal placement of thumb (HP:0009623)2.36545360
54Abnormality of the labia minora (HP:0012880)2.36530835
55Cleft eyelid (HP:0000625)2.36034994
56Neoplasm of the pancreas (HP:0002894)2.35803229
57Aplasia involving forearm bones (HP:0009822)2.35712088
58Absent forearm bone (HP:0003953)2.35712088
59Premature graying of hair (HP:0002216)2.35485114
60Ectopic kidney (HP:0000086)2.35094291
61Pili torti (HP:0003777)2.34890971
62Small intestinal stenosis (HP:0012848)2.34286998
63Duodenal stenosis (HP:0100867)2.34286998
64Entropion (HP:0000621)2.33510364
65Bone marrow hypocellularity (HP:0005528)2.31668276
66Lipid accumulation in hepatocytes (HP:0006561)2.31111572
67Thrombocytosis (HP:0001894)2.31106669
68Amaurosis fugax (HP:0100576)2.31064426
69Deviation of the thumb (HP:0009603)2.29155637
70Trismus (HP:0000211)2.28115130
71Septate vagina (HP:0001153)2.27440222
72Mitochondrial inheritance (HP:0001427)2.25487604
73Abnormal hair laboratory examination (HP:0003328)2.25171995
74Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.24646047
75Urethral obstruction (HP:0000796)2.23241583
76Abnormality of glycolysis (HP:0004366)2.22583026
77Abnormality of the astrocytes (HP:0100707)2.22546351
78Astrocytoma (HP:0009592)2.22546351
79Cerebral hypomyelination (HP:0006808)2.22438516
80Prominent nose (HP:0000448)2.20866709
81Nasolacrimal duct obstruction (HP:0000579)2.18891896
82Duplicated collecting system (HP:0000081)2.18336240
83Acute encephalopathy (HP:0006846)2.17577899
84Lymphoma (HP:0002665)2.17338968
85Hepatic necrosis (HP:0002605)2.17287541
86Increased intramyocellular lipid droplets (HP:0012240)2.16919551
87Ragged-red muscle fibers (HP:0003200)2.15075281
88Pancytopenia (HP:0001876)2.14385930
89Sloping forehead (HP:0000340)2.14214750
90Neoplasm of the oral cavity (HP:0100649)2.13293301
91Glioma (HP:0009733)2.12915174
92Increased serum pyruvate (HP:0003542)2.12842842
93Spastic paraparesis (HP:0002313)2.12584816
94Asplenia (HP:0001746)2.09737061
95Atresia of the external auditory canal (HP:0000413)2.08778583
96Severe visual impairment (HP:0001141)2.08404465
97Facial hemangioma (HP:0000329)2.08336467
98Rib fusion (HP:0000902)2.07704630
99Increased nuchal translucency (HP:0010880)2.07330066
100Tracheoesophageal fistula (HP:0002575)2.07003691
101Microretrognathia (HP:0000308)2.06436251
102Multiple enchondromatosis (HP:0005701)2.04621412
103Missing ribs (HP:0000921)2.04095399
104Hypoplasia of the capital femoral epiphysis (HP:0003090)1.99751186
105Aplasia/Hypoplasia of the spleen (HP:0010451)1.99396499
106Horseshoe kidney (HP:0000085)1.99337808
107Respiratory difficulties (HP:0002880)1.99068222
108Cellular immunodeficiency (HP:0005374)1.97361217
109Abnormality of the duodenum (HP:0002246)1.96855005
110Supernumerary spleens (HP:0009799)1.95822936
111Short thumb (HP:0009778)1.95626102
112Abnormality of the carotid arteries (HP:0005344)1.95034551
113Cafe-au-lait spot (HP:0000957)1.94960946
114Abnormality of methionine metabolism (HP:0010901)1.94415026
115Abnormality of DNA repair (HP:0003254)1.92842362
116Cerebral edema (HP:0002181)1.91815233
117Facial cleft (HP:0002006)1.91577239
118Abnormality of the renal collecting system (HP:0004742)1.91512356
119Seborrheic dermatitis (HP:0001051)1.91316489
120Poikiloderma (HP:0001029)1.89885175
121Glossoptosis (HP:0000162)1.89138935
122Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.88933640
123Increased muscle lipid content (HP:0009058)1.88414812
124Neoplasm of striated muscle (HP:0009728)1.88412709
125Reduced antithrombin III activity (HP:0001976)1.88296516
126Sparse lateral eyebrow (HP:0005338)1.88107504
127Triphalangeal thumb (HP:0001199)1.87577689
128Cutaneous melanoma (HP:0012056)1.87010443
129Nephroblastoma (Wilms tumor) (HP:0002667)1.86623862
130Lactic acidosis (HP:0003128)1.86405807
131Abnormal lung lobation (HP:0002101)1.85670383
132Hypertensive crisis (HP:0100735)1.85624661
133Hypoplasia of the pons (HP:0012110)1.85265250
134Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.85057304
135Absent epiphyses (HP:0010577)1.85057304
136Aplasia/Hypoplasia of the thymus (HP:0010515)1.84194357
137Testicular atrophy (HP:0000029)1.83642472
138Abnormality of small intestinal villus morphology (HP:0011472)1.82825581
139Villous atrophy (HP:0011473)1.82825581
140Clubbing of toes (HP:0100760)1.82347479
141Aplasia/hypoplasia of the humerus (HP:0006507)1.82090960
142Volvulus (HP:0002580)1.81624859
143Hypokinesia (HP:0002375)1.80378818
144Abnormal trabecular bone morphology (HP:0100671)1.79090227
145Renal Fanconi syndrome (HP:0001994)1.79060021
146Choanal atresia (HP:0000453)1.78352920
147Premature ovarian failure (HP:0008209)1.77994994
148Overlapping toe (HP:0001845)1.77943617
149Amniotic constriction ring (HP:0009775)1.76765889
150Abnormality of placental membranes (HP:0011409)1.76765889
151Abnormality of reticulocytes (HP:0004312)1.76672919
152High pitched voice (HP:0001620)1.75176832
153Micronodular cirrhosis (HP:0001413)1.74825885
154Secondary amenorrhea (HP:0000869)1.73621805
155IgM deficiency (HP:0002850)1.72367816
156Biliary tract neoplasm (HP:0100574)1.72146349
157Aplasia/Hypoplasia of the sacrum (HP:0008517)1.71286870
158Preauricular skin tag (HP:0000384)1.70814883
159Abnormality of the calcaneus (HP:0008364)1.67239177
160Aplasia/Hypoplasia of the sternum (HP:0006714)1.67187453
161Skin tags (HP:0010609)1.62545345
162Neoplasm of the colon (HP:0100273)1.61910660

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.33665701
2BUB13.77642836
3WEE13.71718930
4VRK23.01863844
5TSSK62.76603156
6NEK22.70418365
7CDK122.70007090
8EEF2K2.50616714
9SMG12.36241047
10SRPK12.33318564
11PBK2.22618079
12EIF2AK12.17938901
13NME22.17086478
14TTK2.16719471
15IRAK32.15650798
16MST1R2.10437124
17NME12.08361760
18PASK2.07518226
19RPS6KB22.04616700
20PLK11.93403765
21CDK71.88064888
22MKNK11.87584041
23EPHA21.84463786
24ATR1.75908452
25EIF2AK31.72573923
26AURKB1.69612491
27STK101.65904039
28BRSK21.65332040
29MKNK21.63470403
30CDK41.60129218
31ACVR1B1.56444712
32MAP4K11.56059541
33TLK11.55478187
34PLK41.52527901
35NEK11.47881820
36DYRK31.45335247
37CHEK11.43161682
38VRK11.43121406
39TRIB31.39647928
40TESK21.38524419
41MAP3K101.36469622
42MAP2K21.36304867
43ERN11.36212727
44MAP3K81.35701997
45PLK31.35310313
46CHEK21.32079566
47STK161.30948380
48RPS6KA41.30575463
49BRD41.29259563
50SCYL21.23897155
51PIM11.23619576
52ZAK1.21716554
53AURKA1.19358393
54TESK11.18903077
55ALK1.14168437
56PIM21.12753528
57PDK21.09868188
58STK41.09783015
59TGFBR11.08817292
60TAF11.08534453
61PAK41.04350400
62SIK10.99245200
63ATM0.95987060
64FLT30.95155911
65CDK20.94891946
66PNCK0.93362488
67CDK80.91138185
68PKN20.90047897
69MAPK110.88615756
70MAP3K140.82399270
71BRSK10.80229251
72LRRK20.78450086
73FGFR40.77988498
74CDK60.77901028
75CSNK2A20.77027150
76JAK30.75340140
77GRK60.70185982
78EIF2AK20.69121371
79ICK0.67651338
80CDK10.67235417
81MTOR0.67164505
82PAK10.64331307
83TEC0.61469523
84CSNK2A10.60084777
85MAP2K30.59832919
86IKBKB0.59517257
87IRAK40.59307028
88MAPKAPK30.59299266
89BTK0.59048918
90TAOK30.58931871
91CDK90.57088820
92ZAP700.57054510
93STK30.56922307
94RPS6KA50.56421264
95PRKCI0.55044987
96BRAF0.53521236
97CHUK0.51530795
98PAK20.51123007
99ABL20.51023950
100NEK60.50940913
101LATS10.50588907
102MET0.49891073
103ARAF0.47729809
104MST40.47561633
105CSNK1E0.46980599
106AKT20.46724148
107TXK0.46583603
108WNK40.45053534
109BMX0.44849894
110CLK10.44700167
111MAP3K90.44604574
112DAPK10.44414930
113SIK30.44291006
114NUAK10.42981344
115MAP3K110.42836708
116CSF1R0.40837006
117SIK20.40087215
118PTK60.37955492
119PRKDC0.37805129
120MAP3K30.37509187
121MELK0.37217126
122KDR0.36976444
123LATS20.35843562
124MARK30.34049285
125PDPK10.33467901
126MAPK140.32811586
127BLK0.32769183
128RPS6KB10.32071539
129CSNK1D0.29234674
130RAF10.27231825
131LCK0.26476253
132MAPKAPK20.25947181
133RPS6KA10.24713514
134TAOK20.24654638
135MAPK10.24301594
136CCNB10.23247137

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.75765299
2Mismatch repair_Homo sapiens_hsa034304.04916726
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.85757426
4Spliceosome_Homo sapiens_hsa030403.35090686
5Ribosome_Homo sapiens_hsa030103.26760825
6RNA transport_Homo sapiens_hsa030133.11759922
7RNA polymerase_Homo sapiens_hsa030203.08090629
8Base excision repair_Homo sapiens_hsa034102.91145066
9One carbon pool by folate_Homo sapiens_hsa006702.88759167
10Homologous recombination_Homo sapiens_hsa034402.83898020
11Nucleotide excision repair_Homo sapiens_hsa034202.79028441
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.75716672
13Cell cycle_Homo sapiens_hsa041102.55267581
14Proteasome_Homo sapiens_hsa030502.55072024
15Fanconi anemia pathway_Homo sapiens_hsa034602.25822592
16Pyrimidine metabolism_Homo sapiens_hsa002402.24360914
17Non-homologous end-joining_Homo sapiens_hsa034502.21775107
18mRNA surveillance pathway_Homo sapiens_hsa030151.84461127
19RNA degradation_Homo sapiens_hsa030181.81407347
20Basal transcription factors_Homo sapiens_hsa030221.77021799
21p53 signaling pathway_Homo sapiens_hsa041151.65752514
22Epstein-Barr virus infection_Homo sapiens_hsa051691.31294940
23Oxidative phosphorylation_Homo sapiens_hsa001901.29905835
24Systemic lupus erythematosus_Homo sapiens_hsa053221.29788246
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25417143
26Huntingtons disease_Homo sapiens_hsa050161.18414830
27Viral carcinogenesis_Homo sapiens_hsa052031.16238856
28Herpes simplex infection_Homo sapiens_hsa051681.14728263
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14081957
30Parkinsons disease_Homo sapiens_hsa050121.12738685
31Purine metabolism_Homo sapiens_hsa002301.10106618
32Antigen processing and presentation_Homo sapiens_hsa046121.09792078
33Primary immunodeficiency_Homo sapiens_hsa053401.05236580
34Protein export_Homo sapiens_hsa030600.99854525
35Cyanoamino acid metabolism_Homo sapiens_hsa004600.94980690
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93157519
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87723669
38HTLV-I infection_Homo sapiens_hsa051660.86364738
39NF-kappa B signaling pathway_Homo sapiens_hsa040640.81535733
40Small cell lung cancer_Homo sapiens_hsa052220.79417494
41Selenocompound metabolism_Homo sapiens_hsa004500.79322543
42MicroRNAs in cancer_Homo sapiens_hsa052060.74523840
43Pentose phosphate pathway_Homo sapiens_hsa000300.73912589
44Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73885702
45Vitamin B6 metabolism_Homo sapiens_hsa007500.72299960
46Biosynthesis of amino acids_Homo sapiens_hsa012300.71379968
47Measles_Homo sapiens_hsa051620.71199258
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.70628769
49Thyroid cancer_Homo sapiens_hsa052160.69125880
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68482407
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67101671
52Apoptosis_Homo sapiens_hsa042100.63733830
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63574498
54Legionellosis_Homo sapiens_hsa051340.63229871
55Pyruvate metabolism_Homo sapiens_hsa006200.61903299
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.61111886
57Sulfur relay system_Homo sapiens_hsa041220.60236427
58Alzheimers disease_Homo sapiens_hsa050100.60144390
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59262974
60Oocyte meiosis_Homo sapiens_hsa041140.56695249
61Acute myeloid leukemia_Homo sapiens_hsa052210.54459986
62Folate biosynthesis_Homo sapiens_hsa007900.54010462
63Fatty acid elongation_Homo sapiens_hsa000620.53153864
64Chronic myeloid leukemia_Homo sapiens_hsa052200.51200307
65Hepatitis B_Homo sapiens_hsa051610.51007761
66Notch signaling pathway_Homo sapiens_hsa043300.49796300
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47129458
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44960605
69Hematopoietic cell lineage_Homo sapiens_hsa046400.44664155
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44618640
71Metabolic pathways_Homo sapiens_hsa011000.42932157
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41826815
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41512574
74Shigellosis_Homo sapiens_hsa051310.39990837
75Other glycan degradation_Homo sapiens_hsa005110.39627112
76T cell receptor signaling pathway_Homo sapiens_hsa046600.39235054
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38374832
78Galactose metabolism_Homo sapiens_hsa000520.37657301
79Bladder cancer_Homo sapiens_hsa052190.36814265
80Influenza A_Homo sapiens_hsa051640.36699131
81Colorectal cancer_Homo sapiens_hsa052100.36348026
82Alcoholism_Homo sapiens_hsa050340.35952117
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.35376913
84Glutathione metabolism_Homo sapiens_hsa004800.35370617
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34818170
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34057429
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33584160
88Vitamin digestion and absorption_Homo sapiens_hsa049770.32884885
89Fatty acid biosynthesis_Homo sapiens_hsa000610.32593586
90Basal cell carcinoma_Homo sapiens_hsa052170.32478454
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.32421237
92Hippo signaling pathway_Homo sapiens_hsa043900.32379332
93HIF-1 signaling pathway_Homo sapiens_hsa040660.30853512
94Allograft rejection_Homo sapiens_hsa053300.30745303
95Pathways in cancer_Homo sapiens_hsa052000.30373481
96TGF-beta signaling pathway_Homo sapiens_hsa043500.30368040
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30009347
98Fructose and mannose metabolism_Homo sapiens_hsa000510.29843610
99Viral myocarditis_Homo sapiens_hsa054160.29760522
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29298218
101Prostate cancer_Homo sapiens_hsa052150.29070926
102B cell receptor signaling pathway_Homo sapiens_hsa046620.28556383
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.28295430
104mTOR signaling pathway_Homo sapiens_hsa041500.26449627
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25557632
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22730844
107Lysine degradation_Homo sapiens_hsa003100.22413320
108Leishmaniasis_Homo sapiens_hsa051400.21971086
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21666528
110N-Glycan biosynthesis_Homo sapiens_hsa005100.21385555
111Adherens junction_Homo sapiens_hsa045200.19979873
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18935583
113Non-small cell lung cancer_Homo sapiens_hsa052230.18769358
114Toxoplasmosis_Homo sapiens_hsa051450.18616461
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17912247
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.17518400
117Graft-versus-host disease_Homo sapiens_hsa053320.17244134
118Asthma_Homo sapiens_hsa053100.16806924
119Autoimmune thyroid disease_Homo sapiens_hsa053200.16705631
120Pancreatic cancer_Homo sapiens_hsa052120.16667626
121Carbon metabolism_Homo sapiens_hsa012000.16653523
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.15933363
123Arachidonic acid metabolism_Homo sapiens_hsa005900.14067625
124Hepatitis C_Homo sapiens_hsa051600.12209793
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08740386

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