DDX25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain testicular functions related to steroidogenesis and spermatogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.14573074
2fusion of sperm to egg plasma membrane (GO:0007342)7.38539137
3sperm motility (GO:0030317)7.21522893
4piRNA metabolic process (GO:0034587)7.04664793
5acrosome reaction (GO:0007340)6.75192652
6acrosome assembly (GO:0001675)6.61889990
7axonemal dynein complex assembly (GO:0070286)6.31798324
8epithelial cilium movement (GO:0003351)6.27641870
9sperm-egg recognition (GO:0035036)6.11435518
10plasma membrane fusion (GO:0045026)6.01193219
11multicellular organism reproduction (GO:0032504)5.98959530
12cell wall macromolecule catabolic process (GO:0016998)5.74828501
13cell wall macromolecule metabolic process (GO:0044036)5.74828501
14male meiosis (GO:0007140)5.74574813
15binding of sperm to zona pellucida (GO:0007339)5.56886094
16cilium movement (GO:0003341)5.51254242
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.43524207
18cell-cell recognition (GO:0009988)5.39210869
19motile cilium assembly (GO:0044458)5.38771870
20synaptonemal complex organization (GO:0070193)5.28193372
21regulation of cilium movement (GO:0003352)5.28139923
22* spermatid development (GO:0007286)5.14445014
23synaptonemal complex assembly (GO:0007130)4.93884103
24reproduction (GO:0000003)4.85764020
25calcium ion-dependent exocytosis (GO:0017156)4.84435220
26behavioral response to nicotine (GO:0035095)4.75586732
27DNA methylation involved in gamete generation (GO:0043046)4.75326760
28regulation of short-term neuronal synaptic plasticity (GO:0048172)4.36421142
29negative regulation of inclusion body assembly (GO:0090084)4.22726988
30protein localization to cilium (GO:0061512)4.22539832
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.21800457
32single fertilization (GO:0007338)4.08571955
33synaptic vesicle exocytosis (GO:0016079)4.06969364
34vocalization behavior (GO:0071625)3.97120389
35neuron cell-cell adhesion (GO:0007158)3.95219393
36sperm capacitation (GO:0048240)3.92412274
37ventricular system development (GO:0021591)3.83858539
38regulation of synaptic vesicle exocytosis (GO:2000300)3.81999508
39regulation of microtubule-based movement (GO:0060632)3.81074275
40protein localization to synapse (GO:0035418)3.79978894
41regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.77776361
42positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.64766666
43glutamate secretion (GO:0014047)3.63070103
44synaptic vesicle maturation (GO:0016188)3.59952873
45fertilization (GO:0009566)3.59588196
46spermatogenesis (GO:0007283)3.58814584
47male gamete generation (GO:0048232)3.57457678
48cell recognition (GO:0008037)3.56013037
49presynaptic membrane assembly (GO:0097105)3.55514058
50male meiosis I (GO:0007141)3.54982213
51regulation of inclusion body assembly (GO:0090083)3.50138126
52regulation of synaptic vesicle transport (GO:1902803)3.45128286
53microtubule severing (GO:0051013)3.44855495
54pyrimidine nucleobase catabolic process (GO:0006208)3.43445381
55regulation of glutamate receptor signaling pathway (GO:1900449)3.42056813
56neurotransmitter secretion (GO:0007269)3.41605266
57microtubule depolymerization (GO:0007019)3.34062843
58gamete generation (GO:0007276)3.29211523
59membrane depolarization during action potential (GO:0086010)3.28853856
60water-soluble vitamin biosynthetic process (GO:0042364)3.28261036
61neuronal action potential (GO:0019228)3.28199646
62retinal cone cell development (GO:0046549)3.26987480
63membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.26134193
64locomotory exploration behavior (GO:0035641)3.24530630
65regulation of action potential (GO:0098900)3.23453400
66ionotropic glutamate receptor signaling pathway (GO:0035235)3.22358138
67postsynaptic membrane organization (GO:0001941)3.20756240
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.19377821
69nucleobase catabolic process (GO:0046113)3.18367315
70negative regulation of organelle assembly (GO:1902116)3.17781287
71presynaptic membrane organization (GO:0097090)3.16433261
72meiotic nuclear division (GO:0007126)3.16392267
73chromosome organization involved in meiosis (GO:0070192)3.16364925
74* germ cell development (GO:0007281)3.15386869
75response to pheromone (GO:0019236)3.14161485
76regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.13747293
77neuronal action potential propagation (GO:0019227)3.13479030
78* cellular process involved in reproduction in multicellular organism (GO:0022412)3.12144056
79protein polyglutamylation (GO:0018095)3.08362564
80intraciliary transport (GO:0042073)3.08120580
81dendritic spine morphogenesis (GO:0060997)3.07178525
82layer formation in cerebral cortex (GO:0021819)3.05860078
83synaptic vesicle docking involved in exocytosis (GO:0016081)3.05061333
84synaptic transmission, glutamatergic (GO:0035249)3.02905803
85neuron-neuron synaptic transmission (GO:0007270)3.02288480
86positive regulation of action potential (GO:0045760)3.01668616
87regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.99665959
88exploration behavior (GO:0035640)2.99616153
89tachykinin receptor signaling pathway (GO:0007217)2.99517194
90microtubule-based movement (GO:0007018)2.99307213
91startle response (GO:0001964)2.97599148
92L-fucose catabolic process (GO:0042355)2.95670728
93fucose catabolic process (GO:0019317)2.95670728
94L-fucose metabolic process (GO:0042354)2.95670728
95reflex (GO:0060004)2.95059372
96positive regulation of synapse maturation (GO:0090129)2.93922848
97detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.92843942
98glycerophospholipid catabolic process (GO:0046475)2.91876290
99neurotransmitter-gated ion channel clustering (GO:0072578)2.91798085
100gamma-aminobutyric acid transport (GO:0015812)2.91282157
101glutamate receptor signaling pathway (GO:0007215)2.90008383
102respiratory chain complex IV assembly (GO:0008535)2.89030191
103negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.88099024
104C4-dicarboxylate transport (GO:0015740)2.87888966
105regulation of meiosis I (GO:0060631)2.87240791
106left/right pattern formation (GO:0060972)2.87046860
107ATP hydrolysis coupled proton transport (GO:0015991)2.86934516
108energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.86934516
109neurotransmitter transport (GO:0006836)2.84679553
110negative regulation of cytosolic calcium ion concentration (GO:0051481)2.84413610
111auditory behavior (GO:0031223)2.83942796
112axoneme assembly (GO:0035082)2.82939329
113nonmotile primary cilium assembly (GO:0035058)2.82721804
114regulation of neuronal synaptic plasticity (GO:0048168)2.81261856
115mechanosensory behavior (GO:0007638)2.81239489
116regulation of protein kinase A signaling (GO:0010738)2.79576463
117synaptic vesicle endocytosis (GO:0048488)2.79436720
118neuron recognition (GO:0008038)2.78700183
119meiosis I (GO:0007127)2.76776148
120righting reflex (GO:0060013)2.76410714
121negative regulation of heart rate (GO:0010459)2.74689996
122protein complex biogenesis (GO:0070271)2.74518863
123regulation of long-term neuronal synaptic plasticity (GO:0048169)2.73802617
124lactate metabolic process (GO:0006089)2.71956774
125cellular ketone body metabolic process (GO:0046950)2.69611437
126synaptic transmission, cholinergic (GO:0007271)2.69268331
127serotonin metabolic process (GO:0042428)2.67491169
128transmission of nerve impulse (GO:0019226)2.66284208
129primary amino compound metabolic process (GO:1901160)2.66261898
130establishment of protein localization to mitochondrial membrane (GO:0090151)2.64056375
131cerebellar Purkinje cell differentiation (GO:0021702)2.63945811
132platelet dense granule organization (GO:0060155)2.63197226
133response to auditory stimulus (GO:0010996)2.61211786
134neuromuscular synaptic transmission (GO:0007274)2.60836449
135spermatid nucleus differentiation (GO:0007289)2.60442513
136membrane depolarization (GO:0051899)2.59454840
137negative regulation of synaptic transmission, GABAergic (GO:0032229)2.58846930
138mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.58279863
139mitochondrial respiratory chain complex I assembly (GO:0032981)2.58279863
140NADH dehydrogenase complex assembly (GO:0010257)2.58279863
141seminiferous tubule development (GO:0072520)2.58037120
142regulation of neurotransmitter levels (GO:0001505)2.57793800
143behavioral response to ethanol (GO:0048149)2.57367832
144multicellular organismal reproductive process (GO:0048609)2.57252335
145action potential (GO:0001508)2.56517584
146detection of light stimulus involved in sensory perception (GO:0050962)2.53876319
147detection of light stimulus involved in visual perception (GO:0050908)2.53876319
148mitochondrial respiratory chain complex assembly (GO:0033108)2.53222479
149urinary tract smooth muscle contraction (GO:0014848)2.52402219
150negative regulation of telomere maintenance (GO:0032205)2.51565240
151indolalkylamine metabolic process (GO:0006586)2.50265323
152protein-cofactor linkage (GO:0018065)2.48174895
153neurofilament cytoskeleton organization (GO:0060052)2.47815643
154mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.47806899
155regulation of neurotransmitter uptake (GO:0051580)2.46443461
156positive regulation of meiosis (GO:0045836)2.44007432
157cytochrome complex assembly (GO:0017004)2.42763999
158synapse assembly (GO:0007416)2.42469424
159proline transport (GO:0015824)2.40925868
160ketone body metabolic process (GO:1902224)2.39774722
161photoreceptor cell maintenance (GO:0045494)2.38122942
162indole-containing compound metabolic process (GO:0042430)2.37298563
163adult walking behavior (GO:0007628)2.36946855
164kidney morphogenesis (GO:0060993)2.36384570
165anterograde axon cargo transport (GO:0008089)2.36062959
166cAMP catabolic process (GO:0006198)2.33601787
167positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.33570386
168cochlea development (GO:0090102)2.33427639
169behavioral defense response (GO:0002209)2.33133162

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.13759403
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.64608593
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.05282986
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80345655
5GBX2_23144817_ChIP-Seq_PC3_Human2.78831533
6REST_21632747_ChIP-Seq_MESCs_Mouse2.68556678
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.66932173
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.38288118
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.33447197
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.28222001
11ZNF274_21170338_ChIP-Seq_K562_Hela2.27857145
12TAF15_26573619_Chip-Seq_HEK293_Human2.19072407
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05399218
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92849463
15* REST_18959480_ChIP-ChIP_MESCs_Mouse1.92726366
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.86829420
17VDR_22108803_ChIP-Seq_LS180_Human1.84487547
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83509327
19EWS_26573619_Chip-Seq_HEK293_Human1.82306711
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80457785
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76252468
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76088418
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73975853
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.72434174
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72162722
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72102762
27RNF2_27304074_Chip-Seq_NSC_Mouse1.70413774
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.69874056
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.69303205
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.68685211
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.66959075
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61443834
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59403280
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.55273493
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55180003
36DROSHA_22980978_ChIP-Seq_HELA_Human1.55130663
37SMAD4_21799915_ChIP-Seq_A2780_Human1.54962377
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.50675166
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.49236258
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49044269
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41582597
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41441908
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41190896
44TP53_22573176_ChIP-Seq_HFKS_Human1.41187584
45MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.41096402
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41051062
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41051062
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40484370
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.39025276
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38175974
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.37445707
52RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37063964
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36984201
54IRF1_19129219_ChIP-ChIP_H3396_Human1.36459704
55* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36189370
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35040809
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.32949439
58ELK4_26923725_Chip-Seq_MESODERM_Mouse1.30568451
59KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.30129473
60FUS_26573619_Chip-Seq_HEK293_Human1.27888296
61P300_19829295_ChIP-Seq_ESCs_Human1.25948358
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25702301
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25067409
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23725409
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.22694204
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21955176
67TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.21744899
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21740189
69CBP_20019798_ChIP-Seq_JUKART_Human1.21740189
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21165059
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21143443
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20983313
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20675852
74TCF4_23295773_ChIP-Seq_U87_Human1.20574037
75NANOG_19829295_ChIP-Seq_ESCs_Human1.20563090
76SOX2_19829295_ChIP-Seq_ESCs_Human1.20563090
77AR_21572438_ChIP-Seq_LNCaP_Human1.20528022
78TCF4_22108803_ChIP-Seq_LS180_Human1.20350200
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19194743
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18893767
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18564085
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.17410815
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16941282
84IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16920676
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16515923
86KDM2B_26808549_Chip-Seq_REH_Human1.15649151
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14407563
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14407563
89RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14341535
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13971293
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.13240377
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13227018
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12074225
94AR_25329375_ChIP-Seq_VCAP_Human1.11618677
95STAT3_23295773_ChIP-Seq_U87_Human1.11539101
96ER_23166858_ChIP-Seq_MCF-7_Human1.11402206
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.11071741
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10798816
99GABP_17652178_ChIP-ChIP_JURKAT_Human1.09985887
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09446913
101MYC_18940864_ChIP-ChIP_HL60_Human1.09241428
102FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08896459
103FOXA1_25329375_ChIP-Seq_VCAP_Human1.08896459
104EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08049665
105KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07713940
106SMAD3_21741376_ChIP-Seq_ESCs_Human1.07339091
107ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07018561
108CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06982427
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.06822952
110EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06467278
111SOX9_26525672_Chip-Seq_HEART_Mouse1.05438649
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05051873
113NFE2_27457419_Chip-Seq_LIVER_Mouse1.04900546
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04813335
115TAL1_26923725_Chip-Seq_HPCs_Mouse1.04691704
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04540748
117PRDM14_20953172_ChIP-Seq_ESCs_Human1.04167906
118MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03968919
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02775336
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01891339
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01615777
122WDR5_24793694_ChIP-Seq_LNCAP_Human1.00118154
123EZH2_27294783_Chip-Seq_NPCs_Mouse0.99750701
124SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98175006
125BCAT_22108803_ChIP-Seq_LS180_Human0.97864619
126IGF1R_20145208_ChIP-Seq_DFB_Human0.97494062
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97256246
128SOX2_21211035_ChIP-Seq_LN229_Gbm0.96643191
129MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96077118
130GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.96075345
131RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95192806
132P53_22387025_ChIP-Seq_ESCs_Mouse0.95165889
133RING1B_27294783_Chip-Seq_ESCs_Mouse0.93072955
134RUNX2_22187159_ChIP-Seq_PCA_Human0.91191560

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.66822688
2MP0003880_abnormal_central_pattern4.16997926
3MP0004859_abnormal_synaptic_plasticity4.15687935
4MP0008877_abnormal_DNA_methylation3.58605348
5MP0003635_abnormal_synaptic_transmissio3.19295945
6MP0009046_muscle_twitch3.12824664
7* MP0003698_abnormal_male_reproductive2.95507850
8MP0004270_analgesia2.91737996
9MP0009745_abnormal_behavioral_response2.62666027
10MP0002063_abnormal_learning/memory/cond2.59642330
11MP0001968_abnormal_touch/_nociception2.54197139
12MP0002064_seizures2.49281678
13* MP0001929_abnormal_gametogenesis2.47365265
14MP0002572_abnormal_emotion/affect_behav2.35808932
15MP0005423_abnormal_somatic_nervous2.35622964
16MP0006276_abnormal_autonomic_nervous2.22906459
17MP0002272_abnormal_nervous_system2.19559592
18MP0002734_abnormal_mechanical_nocicepti2.19233253
19MP0002736_abnormal_nociception_after2.02114574
20MP0001984_abnormal_olfaction2.00705494
21MP0002653_abnormal_ependyma_morphology1.97714829
22MP0001486_abnormal_startle_reflex1.97207434
23MP0002822_catalepsy1.96778779
24MP0002735_abnormal_chemical_nociception1.96144465
25MP0001440_abnormal_grooming_behavior1.93770403
26MP0003122_maternal_imprinting1.78490712
27MP0002733_abnormal_thermal_nociception1.77571303
28MP0001529_abnormal_vocalization1.75459831
29MP0002067_abnormal_sensory_capabilities1.74529995
30MP0002184_abnormal_innervation1.67953148
31* MP0002210_abnormal_sex_determination1.67690765
32MP0003195_calcinosis1.62779427
33MP0003787_abnormal_imprinting1.62208897
34MP0001501_abnormal_sleep_pattern1.61961087
35* MP0002161_abnormal_fertility/fecundity1.60739760
36MP0006292_abnormal_olfactory_placode1.60249096
37MP0002557_abnormal_social/conspecific_i1.59804530
38MP0000778_abnormal_nervous_system1.59642797
39MP0001970_abnormal_pain_threshold1.58542412
40MP0001485_abnormal_pinna_reflex1.54819049
41MP0004811_abnormal_neuron_physiology1.54282761
42MP0003136_yellow_coat_color1.44287636
43MP0005645_abnormal_hypothalamus_physiol1.43892766
44MP0004133_heterotaxia1.42311717
45MP0008569_lethality_at_weaning1.41724754
46MP0000955_abnormal_spinal_cord1.40772772
47* MP0001145_abnormal_male_reproductive1.39847960
48MP0005386_behavior/neurological_phenoty1.38023339
49MP0004924_abnormal_behavior1.38023339
50MP0004147_increased_porphyrin_level1.37245699
51MP0002909_abnormal_adrenal_gland1.36189477
52MP0004142_abnormal_muscle_tone1.36115931
53MP0003329_amyloid_beta_deposits1.35745359
54MP0003879_abnormal_hair_cell1.32435936
55MP0002938_white_spotting1.32197237
56MP0004233_abnormal_muscle_weight1.31489283
57MP0005646_abnormal_pituitary_gland1.29648532
58MP0001905_abnormal_dopamine_level1.26477097
59* MP0000653_abnormal_sex_gland1.25206841
60MP0002882_abnormal_neuron_morphology1.24604657
61MP0001502_abnormal_circadian_rhythm1.18918635
62MP0002066_abnormal_motor_capabilities/c1.18621407
63MP0002160_abnormal_reproductive_system1.16015568
64MP0005551_abnormal_eye_electrophysiolog1.12878602
65MP0005623_abnormal_meninges_morphology1.11398234
66MP0009780_abnormal_chondrocyte_physiolo1.10308558
67MP0002152_abnormal_brain_morphology1.10300060
68MP0002277_abnormal_respiratory_mucosa1.05864535
69MP0003011_delayed_dark_adaptation1.05652624
70MP0003646_muscle_fatigue1.03759771
71MP0005379_endocrine/exocrine_gland_phen1.03553945
72MP0010386_abnormal_urinary_bladder1.01641798
73MP0004858_abnormal_nervous_system1.00656323
74MP0000013_abnormal_adipose_tissue0.98682101
75MP0002638_abnormal_pupillary_reflex0.97451901
76MP0002751_abnormal_autonomic_nervous0.96465749
77MP0004742_abnormal_vestibular_system0.94073579
78MP0003718_maternal_effect0.94060036
79MP0006072_abnormal_retinal_apoptosis0.91994772
80MP0003119_abnormal_digestive_system0.90609810
81MP0000751_myopathy0.90457987
82MP0005174_abnormal_tail_pigmentation0.90413400
83MP0008789_abnormal_olfactory_epithelium0.89979092
84MP0002229_neurodegeneration0.88743298
85MP0003121_genomic_imprinting0.87654334
86MP0005084_abnormal_gallbladder_morpholo0.86887419
87MP0003633_abnormal_nervous_system0.86390155
88MP0000569_abnormal_digit_pigmentation0.84964550
89MP0004145_abnormal_muscle_electrophysio0.84919045
90MP0000566_synostosis0.84515704
91MP0000631_abnormal_neuroendocrine_gland0.84027159
92MP0003283_abnormal_digestive_organ0.83406068
93MP0008875_abnormal_xenobiotic_pharmacok0.83293997
94MP0002837_dystrophic_cardiac_calcinosis0.83199758
95MP0000427_abnormal_hair_cycle0.82619802
96MP0003631_nervous_system_phenotype0.81650454
97MP0002752_abnormal_somatic_nervous0.80982257
98MP0004885_abnormal_endolymph0.80620218
99MP0005195_abnormal_posterior_eye0.80150349
100MP0002693_abnormal_pancreas_physiology0.79419154
101MP0001188_hyperpigmentation0.78637653
102MP0000026_abnormal_inner_ear0.78282339
103MP0005499_abnormal_olfactory_system0.77742784
104MP0005394_taste/olfaction_phenotype0.77742784
105MP0003861_abnormal_nervous_system0.76544712
106MP0002102_abnormal_ear_morphology0.76172846
107MP0001944_abnormal_pancreas_morphology0.76153592
108MP0002069_abnormal_eating/drinking_beha0.75300228
109MP0004043_abnormal_pH_regulation0.74645909
110MP0001963_abnormal_hearing_physiology0.74425493
111MP0008872_abnormal_physiological_respon0.74380550
112MP0001986_abnormal_taste_sensitivity0.72510661
113MP0005253_abnormal_eye_physiology0.72214818
114MP0008995_early_reproductive_senescence0.71557729
115MP0003123_paternal_imprinting0.69739970
116MP0003634_abnormal_glial_cell0.64776399
117MP0004085_abnormal_heartbeat0.63084587
118MP0005535_abnormal_body_temperature0.62297001
119MP0003632_abnormal_nervous_system0.60136161
120MP0002876_abnormal_thyroid_physiology0.59539633
121MP0002234_abnormal_pharynx_morphology0.58652099
122MP0006035_abnormal_mitochondrial_morpho0.57737221
123MP0003183_abnormal_peptide_metabolism0.55366084

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)8.73747971
2Absent/shortened dynein arms (HP:0200106)8.73747971
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.68013697
4Abnormal respiratory motile cilium physiology (HP:0012261)6.55172826
5Abnormal respiratory motile cilium morphology (HP:0005938)6.34488818
6Abnormal respiratory epithelium morphology (HP:0012253)6.34488818
7Abnormal ciliary motility (HP:0012262)5.54836808
8Rhinitis (HP:0012384)5.52061983
9Infertility (HP:0000789)4.60060202
10Chronic bronchitis (HP:0004469)4.55726656
11Focal motor seizures (HP:0011153)4.35446142
12Myokymia (HP:0002411)3.66604888
13Abnormality of the lower motor neuron (HP:0002366)3.58382464
14Focal seizures (HP:0007359)3.39877982
15Nephronophthisis (HP:0000090)3.33489291
16Pancreatic cysts (HP:0001737)3.32297034
17Medial flaring of the eyebrow (HP:0010747)3.30206034
18Progressive cerebellar ataxia (HP:0002073)3.24618854
19Epileptic encephalopathy (HP:0200134)3.20183907
20Atonic seizures (HP:0010819)3.17445763
21Congenital stationary night blindness (HP:0007642)3.09716819
22Visual hallucinations (HP:0002367)3.09568859
23Abnormality of the labia minora (HP:0012880)3.04647970
24True hermaphroditism (HP:0010459)3.02675297
25Pancreatic fibrosis (HP:0100732)3.00013588
26Amyotrophic lateral sclerosis (HP:0007354)2.98978896
27Gait imbalance (HP:0002141)2.95571968
28Nasal polyposis (HP:0100582)2.81275492
29Gaze-evoked nystagmus (HP:0000640)2.68812042
30Congenital primary aphakia (HP:0007707)2.68587099
31Type II lissencephaly (HP:0007260)2.66751007
32Febrile seizures (HP:0002373)2.66474896
33Bronchiectasis (HP:0002110)2.64588608
34Absence seizures (HP:0002121)2.53986954
35Intestinal atresia (HP:0011100)2.53696657
36Methylmalonic aciduria (HP:0012120)2.53349725
37Abnormality of the renal cortex (HP:0011035)2.45963282
38Acute necrotizing encephalopathy (HP:0006965)2.41809770
39Hypothermia (HP:0002045)2.41507694
40Failure to thrive in infancy (HP:0001531)2.39590340
41Nephrogenic diabetes insipidus (HP:0009806)2.38751291
42Abnormal drinking behavior (HP:0030082)2.36558779
43Polydipsia (HP:0001959)2.36558779
44Abnormality of the renal medulla (HP:0100957)2.35366120
45Abolished electroretinogram (ERG) (HP:0000550)2.33580063
46Limb dystonia (HP:0002451)2.32403105
47Hyperventilation (HP:0002883)2.32015376
48Large for gestational age (HP:0001520)2.30244158
49Progressive macrocephaly (HP:0004481)2.29948864
50Methylmalonic acidemia (HP:0002912)2.28697209
51Attenuation of retinal blood vessels (HP:0007843)2.27095192
52Optic nerve hypoplasia (HP:0000609)2.26270073
53Abnormality of midbrain morphology (HP:0002418)2.26107164
54Molar tooth sign on MRI (HP:0002419)2.26107164
55Mitochondrial inheritance (HP:0001427)2.26037071
56Pendular nystagmus (HP:0012043)2.24368238
57Dialeptic seizures (HP:0011146)2.23839940
58Hemiparesis (HP:0001269)2.23721332
59Abnormality of ocular smooth pursuit (HP:0000617)2.21914835
60Polyphagia (HP:0002591)2.21738385
61Bronchitis (HP:0012387)2.21738037
62Generalized tonic-clonic seizures (HP:0002069)2.21423270
63Truncal ataxia (HP:0002078)2.19424381
64Progressive inability to walk (HP:0002505)2.17713039
65Genital tract atresia (HP:0001827)2.15762480
66Impaired vibration sensation in the lower limbs (HP:0002166)2.15364193
67Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14886325
68Male infertility (HP:0003251)2.14747276
69Increased CSF lactate (HP:0002490)2.14636969
70Supranuclear gaze palsy (HP:0000605)2.14546880
71Vaginal atresia (HP:0000148)2.13794513
72Colon cancer (HP:0003003)2.12286631
73Hypomagnesemia (HP:0002917)2.10100732
74Acute encephalopathy (HP:0006846)2.08945310
75Abnormality of alanine metabolism (HP:0010916)2.05234941
76Hyperalaninemia (HP:0003348)2.05234941
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05234941
78Abnormality of the nasal mucosa (HP:0000433)2.04675359
79Hyperglycinemia (HP:0002154)2.03978195
80Specific learning disability (HP:0001328)2.02364126
81Abnormal eating behavior (HP:0100738)2.01731710
82Abnormal mitochondria in muscle tissue (HP:0008316)2.01614942
83Lissencephaly (HP:0001339)1.99193893
84Dysdiadochokinesis (HP:0002075)1.98403592
85Poor coordination (HP:0002370)1.97875685
86Agitation (HP:0000713)1.97208294
87Gonadotropin excess (HP:0000837)1.96448218
88Amblyopia (HP:0000646)1.96005476
89Ankle clonus (HP:0011448)1.95280643
90Cystic liver disease (HP:0006706)1.94783146
91Chronic hepatic failure (HP:0100626)1.94715413
92Impaired smooth pursuit (HP:0007772)1.94685823
93Tubular atrophy (HP:0000092)1.94076502
94Oligodactyly (hands) (HP:0001180)1.93528721
95Ketoacidosis (HP:0001993)1.93008629
96Tubulointerstitial nephritis (HP:0001970)1.91122555
97Polyuria (HP:0000103)1.89636413
98Hypoplasia of the brainstem (HP:0002365)1.89629312
99Aplasia/Hypoplasia of the brainstem (HP:0007362)1.89629312
100Renal cortical cysts (HP:0000803)1.89546782
101Broad-based gait (HP:0002136)1.89411481
102Pheochromocytoma (HP:0002666)1.89147339
103Optic disc pallor (HP:0000543)1.88124569
104Sclerocornea (HP:0000647)1.87500290
105Decreased central vision (HP:0007663)1.85686065
106Aplasia/Hypoplasia of the lens (HP:0008063)1.85274901
107Hepatocellular necrosis (HP:0001404)1.85177507
108Depression (HP:0000716)1.84108056
109Abnormal rod and cone electroretinograms (HP:0008323)1.83988250
110Action tremor (HP:0002345)1.83690486
111Inability to walk (HP:0002540)1.83201381
112Urinary bladder sphincter dysfunction (HP:0002839)1.81668439
113Lipid accumulation in hepatocytes (HP:0006561)1.81550947
114Postural instability (HP:0002172)1.81155859
115Septo-optic dysplasia (HP:0100842)1.80845934
116Anencephaly (HP:0002323)1.80749906
117Urinary urgency (HP:0000012)1.78841222
118Retinal dysplasia (HP:0007973)1.77524513
119Postaxial hand polydactyly (HP:0001162)1.76802112
120Bony spicule pigmentary retinopathy (HP:0007737)1.76480733
121Mutism (HP:0002300)1.76358507
122Spastic gait (HP:0002064)1.75407962
123Abnormal hair whorl (HP:0010721)1.74777183
124Recurrent otitis media (HP:0000403)1.74267227
125Epileptiform EEG discharges (HP:0011182)1.73662677
126Increased hepatocellular lipid droplets (HP:0006565)1.73417743
127Hepatic necrosis (HP:0002605)1.73397459
128Abnormality of the corticospinal tract (HP:0002492)1.72043255
129Male pseudohermaphroditism (HP:0000037)1.71727867
130Hypoplasia of the pons (HP:0012110)1.71709479
131Abnormality of the pons (HP:0007361)1.70821099
1323-Methylglutaconic aciduria (HP:0003535)1.70488565
133EEG with generalized epileptiform discharges (HP:0011198)1.69342319
134Absent speech (HP:0001344)1.69317216
135Ketosis (HP:0001946)1.68243192
136Poor suck (HP:0002033)1.66770451
137Status epilepticus (HP:0002133)1.66731317
138Cerebral inclusion bodies (HP:0100314)1.66684196
139Abnormality of vitamin B metabolism (HP:0004340)1.66631427
140Impaired vibratory sensation (HP:0002495)1.65583816
141Dysmetria (HP:0001310)1.65222238
142Gait ataxia (HP:0002066)1.64428711
143Neuroendocrine neoplasm (HP:0100634)1.63249334
144Drooling (HP:0002307)1.63111198
145Excessive salivation (HP:0003781)1.63111198
146Neurofibrillary tangles (HP:0002185)1.62582580
147Delusions (HP:0000746)1.60759207
148Oculomotor apraxia (HP:0000657)1.60618068
149Abnormal spermatogenesis (HP:0008669)1.59492008
150Abnormal gallbladder physiology (HP:0012438)1.59446218
151Cholecystitis (HP:0001082)1.59446218
152Fibular hypoplasia (HP:0003038)1.59295549
153Genetic anticipation (HP:0003743)1.56898549
154Hypsarrhythmia (HP:0002521)1.56445714
155Abnormality of saccadic eye movements (HP:0000570)1.56272863
156Limb ataxia (HP:0002070)1.55905433
157Termporal pattern (HP:0011008)1.54863873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.37527464
2PDK45.37527464
3FRK3.90169047
4PRKD33.57149758
5PDK23.23068985
6NTRK33.08237289
7PNCK3.02754205
8MAP3K42.81886635
9TESK12.75001078
10MARK12.61596142
11MAP3K92.52801705
12ZAK2.36402573
13MAP2K72.36144053
14ICK2.32501339
15ADRBK22.30367851
16CASK2.21020526
17MINK12.09817467
18EPHA42.04046356
19MAP4K21.93755073
20NTRK21.93081266
21GRK11.87912284
22PTK2B1.87530210
23TRIM281.70455022
24WNK41.55822318
25STK381.54512605
26NUAK11.53696205
27MAP3K121.48381540
28PAK61.47368053
29CSNK1G11.46700414
30MAP2K41.46554164
31STK391.42967632
32ACVR1B1.41314634
33TLK11.38099617
34RIPK41.34384432
35CSNK1G31.34201832
36INSRR1.32254882
37MKNK21.30498761
38TYRO31.27996822
39PLK21.27167313
40DAPK21.21882251
41GRK51.18952126
42CCNB11.16788237
43PRKCG1.13575758
44NTRK11.13095414
45KSR11.11984435
46MAPK131.10989279
47CSNK1A1L1.10475937
48CDK51.03278907
49VRK11.00455697
50FGFR20.99441051
51CAMKK10.92062072
52TSSK60.91641809
53KSR20.91360079
54CDK190.91329743
55DAPK10.90884919
56UHMK10.90873125
57PLK30.88225413
58WNK10.85942900
59TNIK0.85339881
60CDK180.79257195
61STK38L0.78812045
62CAMK2A0.78254884
63ARAF0.78160007
64PRPF4B0.78054476
65TIE10.77563388
66TAF10.76805913
67PRKCI0.76168787
68CDK140.76004574
69PINK10.75099207
70CDK150.74467576
71PKN10.69073475
72WNK30.68788274
73LMTK20.68578023
74PDK10.67876688
75BRAF0.67166746
76PHKG20.65741857
77PHKG10.65741857
78SIK20.64636826
79CDK11A0.63777814
80BCR0.63447397
81DYRK30.62238505
82SGK4940.59369324
83SGK2230.59369324
84MKNK10.58792386
85MAP2K60.58088308
86FES0.57549945
87DYRK1A0.56891239
88NME10.56620590
89CAMK1G0.56562744
90AKT30.55503778
91MST40.54860121
92BCKDK0.53171232
93TAOK30.53142739
94LATS20.51396993
95BMPR1B0.51313359
96SIK30.51053975
97NLK0.51004383
98STK110.49972348
99MAP3K20.49915003
100RPS6KA50.49208057
101GRK70.48869909
102VRK20.48381515
103CAMK2B0.48373091
104OXSR10.48264247
105BRSK20.47162120
106CSNK1D0.46934695
107CSNK1A10.45631062
108SGK20.44982261
109CSNK1G20.44589454
110PRKG10.43977354
111CAMKK20.43413251
112PLK40.41590024
113MARK20.40881125
114PRKCZ0.39808060
115CDK30.39781915
116MUSK0.38764390
117PLK10.38586767
118PDPK10.37300556
119PAK30.37180903
120BMPR20.35948615
121PRKCA0.35536862
122CAMK10.34791905
123TGFBR10.32953002
124MAPK150.32802470
125RPS6KA30.32145755
126TXK0.30921102
127SGK10.30779310
128PRKCE0.30651669
129PRKAA10.30454789
130NEK60.30165930
131MAPK100.29391998
132RET0.28974446
133BRSK10.28056417
134CAMK2G0.27924320
135CAMK2D0.26961042
136IRAK20.25697105
137PRKCB0.24997736
138MAPKAPK50.24334611
139NEK20.23804191
140DYRK20.23659801
141ADRBK10.23104001
142PRKACA0.23052820
143CSNK1E0.22860778
144RPS6KB10.22687718

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.78066345
2Synaptic vesicle cycle_Homo sapiens_hsa047213.71240531
3Amphetamine addiction_Homo sapiens_hsa050312.77785930
4Long-term potentiation_Homo sapiens_hsa047202.56445147
5Collecting duct acid secretion_Homo sapiens_hsa049662.43701861
6Circadian entrainment_Homo sapiens_hsa047132.39971662
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.37921525
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.36704945
9GABAergic synapse_Homo sapiens_hsa047272.35122382
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.24985185
11Morphine addiction_Homo sapiens_hsa050322.24351092
12Olfactory transduction_Homo sapiens_hsa047402.23964737
13Glutamatergic synapse_Homo sapiens_hsa047242.22543542
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18508437
15Dopaminergic synapse_Homo sapiens_hsa047282.14531392
16Butanoate metabolism_Homo sapiens_hsa006502.09847708
17Insulin secretion_Homo sapiens_hsa049112.03702304
18Taste transduction_Homo sapiens_hsa047421.99045045
19Protein export_Homo sapiens_hsa030601.97115141
20Renin secretion_Homo sapiens_hsa049241.92406403
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.86889918
22Salivary secretion_Homo sapiens_hsa049701.78934443
23Cardiac muscle contraction_Homo sapiens_hsa042601.71879126
24Nitrogen metabolism_Homo sapiens_hsa009101.70352987
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70289645
26Oocyte meiosis_Homo sapiens_hsa041141.68958823
27Cocaine addiction_Homo sapiens_hsa050301.66222520
28Selenocompound metabolism_Homo sapiens_hsa004501.64858408
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55755522
30Huntingtons disease_Homo sapiens_hsa050161.51643479
31Gastric acid secretion_Homo sapiens_hsa049711.51619990
32Cholinergic synapse_Homo sapiens_hsa047251.50557604
33Calcium signaling pathway_Homo sapiens_hsa040201.49516204
34Glucagon signaling pathway_Homo sapiens_hsa049221.47762216
35Dorso-ventral axis formation_Homo sapiens_hsa043201.47550809
36Serotonergic synapse_Homo sapiens_hsa047261.47514912
37RNA polymerase_Homo sapiens_hsa030201.46353986
38Oxidative phosphorylation_Homo sapiens_hsa001901.45889099
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43275974
40Pyruvate metabolism_Homo sapiens_hsa006201.42974131
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42613759
42Vibrio cholerae infection_Homo sapiens_hsa051101.42535854
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39345552
44Long-term depression_Homo sapiens_hsa047301.35469058
45Oxytocin signaling pathway_Homo sapiens_hsa049211.32465210
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29306232
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28181418
48Tryptophan metabolism_Homo sapiens_hsa003801.23925869
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.23861866
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19323107
51Parkinsons disease_Homo sapiens_hsa050121.19105495
52Estrogen signaling pathway_Homo sapiens_hsa049151.18420953
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17040650
54Alzheimers disease_Homo sapiens_hsa050101.14004744
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12592026
56Vitamin B6 metabolism_Homo sapiens_hsa007501.10774284
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10296610
58Homologous recombination_Homo sapiens_hsa034401.10274676
59Gap junction_Homo sapiens_hsa045401.09567819
60Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07210900
61Caffeine metabolism_Homo sapiens_hsa002321.05226882
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05122178
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02785136
64cAMP signaling pathway_Homo sapiens_hsa040241.01890669
65Regulation of autophagy_Homo sapiens_hsa041400.99803761
66Phototransduction_Homo sapiens_hsa047440.99023515
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98734831
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97988993
69Axon guidance_Homo sapiens_hsa043600.95889972
70Steroid biosynthesis_Homo sapiens_hsa001000.92979749
71RNA degradation_Homo sapiens_hsa030180.92365975
72Type II diabetes mellitus_Homo sapiens_hsa049300.91840070
73GnRH signaling pathway_Homo sapiens_hsa049120.91761741
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90575141
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88846416
76Peroxisome_Homo sapiens_hsa041460.88575671
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86306442
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84590092
79Fatty acid biosynthesis_Homo sapiens_hsa000610.82024458
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81009484
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.80580199
82Alcoholism_Homo sapiens_hsa050340.79760905
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79532719
84Melanogenesis_Homo sapiens_hsa049160.78960030
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78085909
86ABC transporters_Homo sapiens_hsa020100.76768798
87beta-Alanine metabolism_Homo sapiens_hsa004100.75475350
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74628652
89Basal transcription factors_Homo sapiens_hsa030220.73183947
90One carbon pool by folate_Homo sapiens_hsa006700.72398447
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71794859
92Pancreatic secretion_Homo sapiens_hsa049720.70683632
93Thyroid hormone synthesis_Homo sapiens_hsa049180.70512457
94Proteasome_Homo sapiens_hsa030500.69520151
95Purine metabolism_Homo sapiens_hsa002300.68522209
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68314853
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67478500
98ErbB signaling pathway_Homo sapiens_hsa040120.65865422
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64047070
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61625265
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.60167671
102Folate biosynthesis_Homo sapiens_hsa007900.59823131
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59440878
104Ovarian steroidogenesis_Homo sapiens_hsa049130.59252238
105Metabolic pathways_Homo sapiens_hsa011000.57788453
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57349315
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.57131222
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.56812780
109Chemical carcinogenesis_Homo sapiens_hsa052040.56665935
110Glioma_Homo sapiens_hsa052140.56529788
111Inositol phosphate metabolism_Homo sapiens_hsa005620.55079628
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53560758
113Type I diabetes mellitus_Homo sapiens_hsa049400.53551822
114MAPK signaling pathway_Homo sapiens_hsa040100.52745180
115Wnt signaling pathway_Homo sapiens_hsa043100.50998321
116mRNA surveillance pathway_Homo sapiens_hsa030150.50311767
117Retinol metabolism_Homo sapiens_hsa008300.49751597
118Arachidonic acid metabolism_Homo sapiens_hsa005900.47951203
119Glycerolipid metabolism_Homo sapiens_hsa005610.46608207
120Non-homologous end-joining_Homo sapiens_hsa034500.46526310
121Hedgehog signaling pathway_Homo sapiens_hsa043400.45965423
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.45653941
123VEGF signaling pathway_Homo sapiens_hsa043700.45580506
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.43776315
125Endocytosis_Homo sapiens_hsa041440.42783777
126Fatty acid elongation_Homo sapiens_hsa000620.41502603
127Choline metabolism in cancer_Homo sapiens_hsa052310.40899152
128Propanoate metabolism_Homo sapiens_hsa006400.39834963
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39756342
130Mineral absorption_Homo sapiens_hsa049780.38150820
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37618245
132Ether lipid metabolism_Homo sapiens_hsa005650.37050413
133Histidine metabolism_Homo sapiens_hsa003400.36015116
134Arginine and proline metabolism_Homo sapiens_hsa003300.34898855
135Ras signaling pathway_Homo sapiens_hsa040140.32591390
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.31717822
137Circadian rhythm_Homo sapiens_hsa047100.30136186
138Insulin signaling pathway_Homo sapiens_hsa049100.30013915
139Fructose and mannose metabolism_Homo sapiens_hsa000510.28905229
140Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28792236
141alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28205217
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27913528
143Linoleic acid metabolism_Homo sapiens_hsa005910.26179102
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26139524
145Phagosome_Homo sapiens_hsa041450.26063075
146Rheumatoid arthritis_Homo sapiens_hsa053230.24741089
147Fanconi anemia pathway_Homo sapiens_hsa034600.24719538
148SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24219605

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