DDX21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.53053296
2nuclear pore organization (GO:0006999)5.46782795
3DNA unwinding involved in DNA replication (GO:0006268)4.73229542
4folic acid-containing compound biosynthetic process (GO:0009396)4.64305740
5protein localization to kinetochore (GO:0034501)4.56813353
6mitotic nuclear envelope disassembly (GO:0007077)4.30167905
7IMP biosynthetic process (GO:0006188)4.25714975
8pore complex assembly (GO:0046931)4.22285451
9establishment of integrated proviral latency (GO:0075713)4.10464186
10membrane disassembly (GO:0030397)4.01006028
11nuclear envelope disassembly (GO:0051081)4.01006028
12formation of translation preinitiation complex (GO:0001731)3.99191470
13nucleobase biosynthetic process (GO:0046112)3.96467400
14maturation of SSU-rRNA (GO:0030490)3.94742924
15DNA replication initiation (GO:0006270)3.82657275
16ribosome assembly (GO:0042255)3.80907751
17protein localization to chromosome, centromeric region (GO:0071459)3.76904008
18IMP metabolic process (GO:0046040)3.75100222
19DNA duplex unwinding (GO:0032508)3.71619605
20DNA geometric change (GO:0032392)3.68816309
21mitotic metaphase plate congression (GO:0007080)3.65906995
22cellular protein complex localization (GO:0034629)3.65457973
23protein complex localization (GO:0031503)3.60619766
24regulation of centriole replication (GO:0046599)3.60455981
25DNA replication-dependent nucleosome assembly (GO:0006335)3.59854216
26DNA replication-dependent nucleosome organization (GO:0034723)3.59854216
27DNA topological change (GO:0006265)3.59369519
28DNA strand elongation involved in DNA replication (GO:0006271)3.59278729
29non-recombinational repair (GO:0000726)3.57855817
30double-strand break repair via nonhomologous end joining (GO:0006303)3.57855817
31ribosome biogenesis (GO:0042254)3.51880157
32heterochromatin organization (GO:0070828)3.50631207
33regulation of translational termination (GO:0006449)3.48222141
34regulation of translational fidelity (GO:0006450)3.46307273
35mitotic sister chromatid cohesion (GO:0007064)3.44650009
36ribosomal large subunit biogenesis (GO:0042273)3.42986576
37tRNA aminoacylation for protein translation (GO:0006418)3.41792468
38DNA strand elongation (GO:0022616)3.39613315
39pre-miRNA processing (GO:0031054)3.38631252
40tRNA aminoacylation (GO:0043039)3.37247626
41amino acid activation (GO:0043038)3.37247626
42regulation of RNA export from nucleus (GO:0046831)3.35571097
43regulation of spindle organization (GO:0090224)3.34209558
44purine nucleobase biosynthetic process (GO:0009113)3.32019566
45ribonucleoprotein complex biogenesis (GO:0022613)3.31918091
46translational termination (GO:0006415)3.29682147
47viral transcription (GO:0019083)3.27988874
48mitotic chromosome condensation (GO:0007076)3.27932320
49mitotic sister chromatid segregation (GO:0000070)3.27265768
50regulation of histone H3-K9 methylation (GO:0051570)3.27194126
51sister chromatid segregation (GO:0000819)3.26681856
52regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.25025593
53metaphase plate congression (GO:0051310)3.23459608
54ribosomal small subunit assembly (GO:0000028)3.21572399
55translational initiation (GO:0006413)3.20469398
56regulation of posttranscriptional gene silencing (GO:0060147)3.19829414
57regulation of gene silencing by miRNA (GO:0060964)3.19829414
58regulation of gene silencing by RNA (GO:0060966)3.19829414
59positive regulation of chromosome segregation (GO:0051984)3.19626502
60DNA replication checkpoint (GO:0000076)3.19301428
61negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.18844804
62chromatin assembly (GO:0031497)3.16434048
63nuclear envelope organization (GO:0006998)3.16367252
64dosage compensation (GO:0007549)3.15342339
65negative regulation of histone methylation (GO:0031061)3.14629734
66regulation of mitotic spindle organization (GO:0060236)3.14479866
67nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.12033223
68regulation of chromosome segregation (GO:0051983)3.10696969
69transcription from mitochondrial promoter (GO:0006390)3.10165855
70telomere maintenance via semi-conservative replication (GO:0032201)3.06731413
71chromosome condensation (GO:0030261)3.06484106
72maturation of 5.8S rRNA (GO:0000460)3.04666689
73rRNA processing (GO:0006364)3.02726437
74negative regulation of chromosome segregation (GO:0051985)3.02361844
75regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.01471225
76histone H2A monoubiquitination (GO:0035518)3.01188122
77negative regulation of RNA splicing (GO:0033119)3.00902941
78spindle checkpoint (GO:0031577)2.98773351
79translational elongation (GO:0006414)2.97893275
80mitotic spindle checkpoint (GO:0071174)2.96866253
81regulation of translational elongation (GO:0006448)2.95283256
82rRNA metabolic process (GO:0016072)2.94264199
83nucleobase-containing small molecule interconversion (GO:0015949)2.93463365
84regulation of mitotic metaphase/anaphase transition (GO:0030071)2.93239076
85regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.93239076
86DNA synthesis involved in DNA repair (GO:0000731)2.93156867
87protein export from nucleus (GO:0006611)2.93086953
88negative regulation of mitotic sister chromatid separation (GO:2000816)2.92929583
89negative regulation of sister chromatid segregation (GO:0033046)2.92929583
90negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.92929583
91negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.92929583
92negative regulation of mitotic sister chromatid segregation (GO:0033048)2.92929583
93establishment of viral latency (GO:0019043)2.92336864
94ribosomal small subunit biogenesis (GO:0042274)2.92206464
95DNA conformation change (GO:0071103)2.91731216
96regulation of nucleobase-containing compound transport (GO:0032239)2.90671230
97chromatin assembly or disassembly (GO:0006333)2.90276156
98mitochondrial RNA metabolic process (GO:0000959)2.90135459
99viral mRNA export from host cell nucleus (GO:0046784)2.89121285
100kinetochore organization (GO:0051383)2.87984044
101regulation of DNA endoreduplication (GO:0032875)2.87235429
102mRNA stabilization (GO:0048255)2.86908798
103RNA stabilization (GO:0043489)2.86908798
104DNA ligation (GO:0006266)2.85748351
105chromosome segregation (GO:0007059)2.85630261
106chromatin remodeling at centromere (GO:0031055)2.85601546
107mitotic recombination (GO:0006312)2.85503209
108mRNA transport (GO:0051028)2.85002301
109folic acid metabolic process (GO:0046655)2.84904602
110pteridine-containing compound biosynthetic process (GO:0042559)2.83805347
111DNA packaging (GO:0006323)2.83728471
112establishment of chromosome localization (GO:0051303)2.83359272
113RNA splicing, via transesterification reactions (GO:0000375)2.81344215
114RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.80977196
115mRNA splicing, via spliceosome (GO:0000398)2.80977196
116spliceosomal tri-snRNP complex assembly (GO:0000244)2.80907199
117protein localization to chromosome (GO:0034502)2.80787066
118negative regulation of mRNA processing (GO:0050686)2.80773922
119DNA replication-independent nucleosome organization (GO:0034724)2.80142071
120DNA replication-independent nucleosome assembly (GO:0006336)2.80142071
121telomere maintenance via recombination (GO:0000722)2.79715554
122regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.77625199
123somatic diversification of immune receptors via somatic mutation (GO:0002566)2.75479825
124somatic hypermutation of immunoglobulin genes (GO:0016446)2.75479825
125regulation of helicase activity (GO:0051095)2.74115139
126CENP-A containing nucleosome assembly (GO:0034080)2.73420851
127alternative mRNA splicing, via spliceosome (GO:0000380)2.71429377
128tetrahydrofolate metabolic process (GO:0046653)2.71316556
129attachment of spindle microtubules to kinetochore (GO:0008608)2.70746317
130peptidyl-arginine omega-N-methylation (GO:0035247)2.69928323
131regulation of centrosome cycle (GO:0046605)2.69062489
132negative regulation of mRNA metabolic process (GO:1903312)2.66275279
133positive regulation of mitotic sister chromatid separation (GO:1901970)2.66274115
134positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.66274115
135positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.66274115
136telomere maintenance via telomere lengthening (GO:0010833)2.66202906
137regulation of sister chromatid cohesion (GO:0007063)2.63935150

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.18959242
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.40618883
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.06104830
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.58641094
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.29026798
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.14067151
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.05943661
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94383252
9MYC_22102868_ChIP-Seq_BL_Human2.58823445
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58057468
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25770898
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.21932052
13* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14070708
14AR_21909140_ChIP-Seq_LNCAP_Human2.11124521
15XRN2_22483619_ChIP-Seq_HELA_Human2.10809112
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.06202267
17* EST1_17652178_ChIP-ChIP_JURKAT_Human1.99670444
18* ETS1_20019798_ChIP-Seq_JURKAT_Human1.98056054
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89862511
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.89703149
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79454947
22MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78939828
23VDR_23849224_ChIP-Seq_CD4+_Human1.77026857
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.75415620
25* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74953053
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.66104219
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65878040
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63717357
29FOXP3_21729870_ChIP-Seq_TREG_Human1.63603028
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.60673112
31* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60306648
32CIITA_25753668_ChIP-Seq_RAJI_Human1.55771676
33KDM5A_27292631_Chip-Seq_BREAST_Human1.54765781
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54707939
35* TTF2_22483619_ChIP-Seq_HELA_Human1.53004870
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52559195
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50262152
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48901429
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48722306
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47406460
41DCP1A_22483619_ChIP-Seq_HELA_Human1.47250213
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45976632
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45821983
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44433058
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43057793
46ELK1_19687146_ChIP-ChIP_HELA_Human1.43030843
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.42717328
48* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41864520
49GABP_19822575_ChIP-Seq_HepG2_Human1.41060585
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39787945
51VDR_21846776_ChIP-Seq_THP-1_Human1.39547346
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37939292
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.37497734
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35124630
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34431568
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.31352182
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.28228690
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27517343
59KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23861341
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23861341
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23861341
62TFEB_21752829_ChIP-Seq_HELA_Human1.23387208
63CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19177527
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16335758
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15246560
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13770644
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13086032
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09981533
69* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08461995
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08306527
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07279153
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05726108
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04109117
74* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02112837
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01395537
76MYB_26560356_Chip-Seq_TH1_Human1.00742174
77UTX_26944678_Chip-Seq_JUKART_Human1.00543914
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00214583
79MAF_26560356_Chip-Seq_TH1_Human0.99486331
80* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99092765
81TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98569706
82TP63_17297297_ChIP-ChIP_HaCaT_Human0.97925866
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97338250
84TCF7_22412390_ChIP-Seq_EML_Mouse0.96587874
85FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96026863
86SOX17_20123909_ChIP-Seq_XEN_Mouse0.95957958
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95892928
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95838867
89ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95520949
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95354035
91* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95291167
92* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94848473
93ZNF263_19887448_ChIP-Seq_K562_Human0.94581946
94* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94245860
95ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94143110
96* MYB_26560356_Chip-Seq_TH2_Human0.92574992
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91799182
98NANOG_21062744_ChIP-ChIP_HESCs_Human0.90421591
99* SPI1_23547873_ChIP-Seq_NB4_Human0.90307149
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90140839
101KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88967040
102* CHD1_26751641_Chip-Seq_LNCaP_Human0.87831142
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87600609
104SRF_21415370_ChIP-Seq_HL-1_Mouse0.87196172
105ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86786820
106NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.86741961
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86413287
108E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.86146681
109YY1_21170310_ChIP-Seq_MESCs_Mouse0.86092624
110ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85405427
111SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84236981
112ATF3_27146783_Chip-Seq_COLON_Human0.84012056
113* MYC_18940864_ChIP-ChIP_HL60_Human0.83763706
114MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82701436
115CLOCK_20551151_ChIP-Seq_293T_Human0.82300186
116KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81603896
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.78947647
118EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.78786499
119CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77659503
120TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.76736722
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74836991
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.74624502
123SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73795812
124HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.73660164
125CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.72750979

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.11354551
2MP0010094_abnormal_chromosome_stability3.72195952
3MP0003111_abnormal_nucleus_morphology3.67986374
4MP0004957_abnormal_blastocyst_morpholog3.63314199
5MP0008057_abnormal_DNA_replication3.49892291
6MP0003077_abnormal_cell_cycle3.32772843
7MP0010352_gastrointestinal_tract_polyps3.16978868
8MP0002396_abnormal_hematopoietic_system2.46130391
9MP0010307_abnormal_tumor_latency2.41967886
10MP0001730_embryonic_growth_arrest2.37047214
11MP0008058_abnormal_DNA_repair2.37044462
12MP0000350_abnormal_cell_proliferation2.25805049
13MP0008007_abnormal_cellular_replicative2.25643561
14MP0009697_abnormal_copulation2.25443262
15MP0005076_abnormal_cell_differentiation2.20015899
16MP0003705_abnormal_hypodermis_morpholog2.09349540
17MP0002009_preneoplasia2.02486910
18MP0008932_abnormal_embryonic_tissue1.96436257
19MP0003123_paternal_imprinting1.92746776
20MP0001672_abnormal_embryogenesis/_devel1.92188692
21MP0005380_embryogenesis_phenotype1.92188692
22MP0003984_embryonic_growth_retardation1.81414450
23MP0002088_abnormal_embryonic_growth/wei1.78640379
24MP0004808_abnormal_hematopoietic_stem1.77848178
25MP0004197_abnormal_fetal_growth/weight/1.75461843
26MP0001697_abnormal_embryo_size1.74876247
27MP0000490_abnormal_crypts_of1.66497091
28MP0002086_abnormal_extraembryonic_tissu1.65276247
29MP0002084_abnormal_developmental_patter1.64550104
30MP0002080_prenatal_lethality1.58844540
31MP0002085_abnormal_embryonic_tissue1.55926749
32MP0003763_abnormal_thymus_physiology1.54016724
33MP0002796_impaired_skin_barrier1.51634730
34MP0003786_premature_aging1.46374985
35MP0003566_abnormal_cell_adhesion1.44787019
36MP0003567_abnormal_fetal_cardiomyocyte1.36689267
37MP0006054_spinal_hemorrhage1.36560125
38MP0008877_abnormal_DNA_methylation1.36423973
39MP0000703_abnormal_thymus_morphology1.35478339
40MP0004233_abnormal_muscle_weight1.35048829
41MP0009333_abnormal_splenocyte_physiolog1.34465627
42MP0002019_abnormal_tumor_incidence1.34158441
43MP0000313_abnormal_cell_death1.29106088
44MP0005501_abnormal_skin_physiology1.28245301
45MP0002398_abnormal_bone_marrow1.28003969
46MP0005451_abnormal_body_composition1.25069962
47MP0001661_extended_life_span1.22607476
48MP0003300_gastrointestinal_ulcer1.22226491
49MP0003890_abnormal_embryonic-extraembry1.20879920
50MP0005023_abnormal_wound_healing1.19111804
51MP0002722_abnormal_immune_system1.18343124
52MP0003221_abnormal_cardiomyocyte_apopto1.16642898
53MP0009278_abnormal_bone_marrow1.12123275
54MP0000689_abnormal_spleen_morphology1.11058693
55MP0000733_abnormal_muscle_development1.11051915
56MP0005397_hematopoietic_system_phenotyp1.09976403
57MP0001545_abnormal_hematopoietic_system1.09976403
58MP0001915_intracranial_hemorrhage1.09952569
59MP0000537_abnormal_urethra_morphology1.07685491
60MP0002877_abnormal_melanocyte_morpholog1.06235049
61MP0001293_anophthalmia1.04166013
62MP0003303_peritoneal_inflammation1.03782872
63MP0006035_abnormal_mitochondrial_morpho1.03291503
64MP0004264_abnormal_extraembryonic_tissu1.01559027
65MP0009053_abnormal_anal_canal1.01308552
66MP0009672_abnormal_birth_weight1.00714666
67MP0003121_genomic_imprinting1.00538008
68MP0000685_abnormal_immune_system0.99068832
69MP0001727_abnormal_embryo_implantation0.99016999
70MP0000358_abnormal_cell_content/0.98458096
71MP0001800_abnormal_humoral_immune0.98116120
72MP0002060_abnormal_skin_morphology0.97240893
73MP0001216_abnormal_epidermal_layer0.95822070
74MP0000858_altered_metastatic_potential0.93978071
75MP0001881_abnormal_mammary_gland0.92735928
76MP0010030_abnormal_orbit_morphology0.92311664
77MP0002429_abnormal_blood_cell0.91239573
78MP0009703_decreased_birth_body0.91172513
79MP0010234_abnormal_vibrissa_follicle0.90935707
80MP0001849_ear_inflammation0.89899334
81MP0002166_altered_tumor_susceptibility0.89057013
82MP0002405_respiratory_system_inflammati0.87081481
83MP0001873_stomach_inflammation0.86982740
84MP0000716_abnormal_immune_system0.86502626
85MP0003448_altered_tumor_morphology0.86198699
86MP0003453_abnormal_keratinocyte_physiol0.85981997
87MP0000579_abnormal_nail_morphology0.85506123
88MP0000428_abnormal_craniofacial_morphol0.84400171
89MP0003950_abnormal_plasma_membrane0.83851221
90MP0003315_abnormal_perineum_morphology0.83058424
91MP0002111_abnormal_tail_morphology0.83033372
92MP0005621_abnormal_cell_physiology0.81239611
93MP0002092_abnormal_eye_morphology0.80946023
94MP0002006_tumorigenesis0.79937621
95MP0000477_abnormal_intestine_morphology0.77599140
96MP0003943_abnormal_hepatobiliary_system0.77322790
97MP0004185_abnormal_adipocyte_glucose0.77207089
98MP0003436_decreased_susceptibility_to0.77049481
99MP0010678_abnormal_skin_adnexa0.76416605
100MP0002452_abnormal_antigen_presenting0.76385347
101MP0002925_abnormal_cardiovascular_devel0.76105329
102MP0001853_heart_inflammation0.75352228
103MP0010155_abnormal_intestine_physiology0.74839102
104MP0003806_abnormal_nucleotide_metabolis0.73883712
105MP0005384_cellular_phenotype0.73420448
106MP0003119_abnormal_digestive_system0.73095562
107MP0003937_abnormal_limbs/digits/tail_de0.72293311
108MP0002420_abnormal_adaptive_immunity0.71852822
109MP0003941_abnormal_skin_development0.70787989
110MP0001286_abnormal_eye_development0.70668071
111MP0001835_abnormal_antigen_presentation0.70636978
112MP0002210_abnormal_sex_determination0.70592965
113MP0001819_abnormal_immune_cell0.70466523
114MP0004947_skin_inflammation0.69925057
115MP0000432_abnormal_head_morphology0.69456248
116MP0002697_abnormal_eye_size0.68106730
117MP0003718_maternal_effect0.67735780
118MP0001348_abnormal_lacrimal_gland0.67613488
119MP0000377_abnormal_hair_follicle0.66878676
120MP0004782_abnormal_surfactant_physiolog0.66865933
121MP0002723_abnormal_immune_serum0.66310308
122MP0000627_abnormal_mammary_gland0.65791013
123MP0008770_decreased_survivor_rate0.64678478
124MP0001145_abnormal_male_reproductive0.64471681
125MP0003656_abnormal_erythrocyte_physiolo0.64409932
126MP0001243_abnormal_dermal_layer0.64017661
127MP0000762_abnormal_tongue_morphology0.61126700
128MP0006036_abnormal_mitochondrial_physio0.57436354
129MP0002098_abnormal_vibrissa_morphology0.56786936
130MP0001929_abnormal_gametogenesis0.56299624
131MP0000678_abnormal_parathyroid_gland0.55548074
132MP0009931_abnormal_skin_appearance0.55009335
133MP0003699_abnormal_female_reproductive0.53110606
134MP0005408_hypopigmentation0.50931031

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.60390168
2Selective tooth agenesis (HP:0001592)3.28408720
3Agnosia (HP:0010524)3.23591290
4Progressive muscle weakness (HP:0003323)3.19568705
5Progressive external ophthalmoplegia (HP:0000590)3.17470390
6Reticulocytopenia (HP:0001896)3.11376852
7Medulloblastoma (HP:0002885)3.05742643
8Nephroblastoma (Wilms tumor) (HP:0002667)2.99976892
9Microvesicular hepatic steatosis (HP:0001414)2.99760564
10Birth length less than 3rd percentile (HP:0003561)2.98766344
11Colon cancer (HP:0003003)2.87180339
12Embryonal renal neoplasm (HP:0011794)2.86251767
13Deviation of the thumb (HP:0009603)2.85105136
14Chromsome breakage (HP:0040012)2.82369215
15Proximal placement of thumb (HP:0009623)2.79599673
16Abnormality of cells of the erythroid lineage (HP:0012130)2.72031330
17Cortical dysplasia (HP:0002539)2.71202960
18Basal cell carcinoma (HP:0002671)2.69818164
19Deep philtrum (HP:0002002)2.60132738
20Rhabdomyosarcoma (HP:0002859)2.58775139
21Abnormality of chromosome stability (HP:0003220)2.56259218
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.54758223
23Increased density of long bones (HP:0006392)2.54707610
24Astrocytoma (HP:0009592)2.49130913
25Abnormality of the astrocytes (HP:0100707)2.49130913
26Ankyloglossia (HP:0010296)2.47578848
27Abnormality of methionine metabolism (HP:0010901)2.46096344
28Abnormal number of erythroid precursors (HP:0012131)2.42272423
29Degeneration of anterior horn cells (HP:0002398)2.39444025
30Abnormality of the anterior horn cell (HP:0006802)2.39444025
31Amaurosis fugax (HP:0100576)2.38301653
32Volvulus (HP:0002580)2.36872454
33Myelodysplasia (HP:0002863)2.31857583
34Abnormal number of incisors (HP:0011064)2.30360561
35Thrombocytosis (HP:0001894)2.29881155
36Biliary tract neoplasm (HP:0100574)2.28267216
37Abnormality of the labia minora (HP:0012880)2.27547962
38Prominent nose (HP:0000448)2.26640558
39Abnormality of homocysteine metabolism (HP:0010919)2.24563683
40Homocystinuria (HP:0002156)2.24563683
41Increased nuchal translucency (HP:0010880)2.23889697
42Patellar aplasia (HP:0006443)2.22520309
43Neoplasm of the oral cavity (HP:0100649)2.20897013
44Absent thumb (HP:0009777)2.20530056
45Oral leukoplakia (HP:0002745)2.18099375
46Breast hypoplasia (HP:0003187)2.18045964
47Septate vagina (HP:0001153)2.17419350
48Spinal cord lesions (HP:0100561)2.16912683
49Syringomyelia (HP:0003396)2.16912683
50Impulsivity (HP:0100710)2.16610295
51Abnormality of the carotid arteries (HP:0005344)2.16300232
52Missing ribs (HP:0000921)2.15723239
53Squamous cell carcinoma (HP:0002860)2.14920301
54Choanal atresia (HP:0000453)2.14866411
55Short middle phalanx of the 5th finger (HP:0004220)2.13663935
56Glioma (HP:0009733)2.12344742
57Abnormality of the preputium (HP:0100587)2.11785967
58Ectopic kidney (HP:0000086)2.10836683
59Abnormality of oral frenula (HP:0000190)2.10364657
60Aplasia/Hypoplasia of the patella (HP:0006498)2.07583815
61Meckel diverticulum (HP:0002245)2.07270066
62Neoplasm of striated muscle (HP:0009728)2.07073651
63Abnormality of the umbilical cord (HP:0010881)2.06664565
64Insidious onset (HP:0003587)2.06413618
65Termporal pattern (HP:0011008)2.06413618
66Trismus (HP:0000211)2.05759628
67Abnormal lung lobation (HP:0002101)2.05258031
68Absent radius (HP:0003974)2.05181797
69Supernumerary ribs (HP:0005815)2.04310071
70Abnormality of glycolysis (HP:0004366)2.03794844
71Neoplasm of the pancreas (HP:0002894)2.03284524
72Gastrointestinal carcinoma (HP:0002672)2.01734998
73Malignant gastrointestinal tract tumors (HP:0006749)2.01734998
74Abnormality of the duodenum (HP:0002246)2.01638120
75Abnormality of the calcaneus (HP:0008364)2.00519456
76Atresia of the external auditory canal (HP:0000413)1.99908809
77Supernumerary bones of the axial skeleton (HP:0009144)1.98559614
7811 pairs of ribs (HP:0000878)1.98460996
79Carpal bone hypoplasia (HP:0001498)1.98307639
80Aplasia/Hypoplasia of the uvula (HP:0010293)1.98239747
81Pelvic girdle muscle weakness (HP:0003749)1.97207109
82Aplastic anemia (HP:0001915)1.95770142
83Cafe-au-lait spot (HP:0000957)1.95490548
84Abnormality of the ileum (HP:0001549)1.94148642
85High pitched voice (HP:0001620)1.92615791
86Horseshoe kidney (HP:0000085)1.92565232
87Sparse lateral eyebrow (HP:0005338)1.92525100
88Rough bone trabeculation (HP:0100670)1.92472114
89Abnormality of the fingertips (HP:0001211)1.92127353
90Premature ovarian failure (HP:0008209)1.91799860
91Macrocytic anemia (HP:0001972)1.91463329
92Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.90882922
93Short 4th metacarpal (HP:0010044)1.90882922
94Abnormality of the fetal cardiovascular system (HP:0010948)1.90216842
95Abnormal umbilical cord blood vessels (HP:0011403)1.90216842
96Single umbilical artery (HP:0001195)1.90216842
97Dysmetric saccades (HP:0000641)1.89995215
98Absent forearm bone (HP:0003953)1.87393103
99Aplasia involving forearm bones (HP:0009822)1.87393103
100Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86847069
101T lymphocytopenia (HP:0005403)1.86829029
102Long eyelashes (HP:0000527)1.85021640
103Cutaneous melanoma (HP:0012056)1.84924140
104Increased serum pyruvate (HP:0003542)1.84733356
105Urethral obstruction (HP:0000796)1.84552426
106Lymphoma (HP:0002665)1.84495191
107Multiple enchondromatosis (HP:0005701)1.83726851
108Pallor (HP:0000980)1.83547255
109Aplasia cutis congenita (HP:0001057)1.83168864
110Overlapping toe (HP:0001845)1.82828240
111Ureteral duplication (HP:0000073)1.82159878
112Upper limb muscle weakness (HP:0003484)1.79909057
113Sandal gap (HP:0001852)1.79696230
114Spastic diplegia (HP:0001264)1.79041416
115Neoplasm of the colon (HP:0100273)1.77683494
116Abnormalities of placenta or umbilical cord (HP:0001194)1.77518037
117Asymmetry of the thorax (HP:0001555)1.77481650
118Absent frontal sinuses (HP:0002688)1.76172032
119Aplasia/hypoplasia of the humerus (HP:0006507)1.76116427
120Small intestinal stenosis (HP:0012848)1.75687038
121Duodenal stenosis (HP:0100867)1.75687038
122Facial hemangioma (HP:0000329)1.74842368
123Clubbing of toes (HP:0100760)1.73933572
124Skin tags (HP:0010609)1.73561189
125Abnormality of the pons (HP:0007361)1.73110022
126Secondary amenorrhea (HP:0000869)1.73068064
127Sensory axonal neuropathy (HP:0003390)1.72940681
128IgM deficiency (HP:0002850)1.71595624
129Orthostatic hypotension (HP:0001278)1.70080540
130Cutis marmorata (HP:0000965)1.69784765
131Abnormality of T cell number (HP:0011839)1.69509103
132Megaloblastic anemia (HP:0001889)1.69269624
133Hypoplasia of the pons (HP:0012110)1.69056904
134Arteriovenous malformation (HP:0100026)1.68437128
135Sloping forehead (HP:0000340)1.68272204
136Sparse eyelashes (HP:0000653)1.67279340
137Acute myeloid leukemia (HP:0004808)1.67115194
138Tracheoesophageal fistula (HP:0002575)1.66737601
139Atrophy/Degeneration involving motor neurons (HP:0007373)1.66190508
140Skull defect (HP:0001362)1.66006290
141Persistence of primary teeth (HP:0006335)1.65643832
142Preauricular skin tag (HP:0000384)1.65369300
143IgA deficiency (HP:0002720)1.65325242
144Short humerus (HP:0005792)1.64179722
145Entropion (HP:0000621)1.64099169
146Premature graying of hair (HP:0002216)1.64021612
147Glossoptosis (HP:0000162)1.63781157
148Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.63191052
149Abnormality of the peritoneum (HP:0002585)1.63147821
150Acute lymphatic leukemia (HP:0006721)1.62947685
151Abnormality of T cells (HP:0002843)1.61844148

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.73068766
2CDK123.43058843
3EEF2K3.18399158
4WEE12.95544153
5PBK2.68115555
6TSSK62.64683444
7NEK22.49857910
8BUB12.41278817
9PKN22.23438068
10SMG12.14176364
11STK102.07892599
12TTK2.06455497
13MST42.05897471
14EIF2AK12.05646114
15RPS6KB22.02119159
16MAP3K101.93850496
17MAP4K11.85779077
18PASK1.83682229
19SRPK11.79654334
20MAP3K81.73872415
21EPHA21.68645992
22ALK1.68364367
23MKNK11.67240789
24CDK41.65348253
25TAF11.63355103
26RPS6KA41.60227567
27CDK71.50255192
28ATR1.48728870
29AURKB1.48012180
30PLK11.47152918
31NEK11.47136871
32TRIB31.45934267
33IRAK31.44008554
34BRD41.43584114
35SCYL21.42142669
36MKNK21.38649501
37CHEK11.38461900
38NME21.37688956
39JAK31.30147455
40PLK31.26324135
41TGFBR11.25902876
42EIF2AK21.24942831
43MST1R1.21007207
44CDK61.20949649
45BRSK21.20463106
46STK31.20183533
47PIM11.19392859
48LRRK21.17118585
49TTN1.15007302
50PLK41.09475136
51FLT31.05179438
52TESK21.04799714
53ACVR1B1.04244809
54TLK11.04151340
55MTOR1.03467248
56CHEK21.02749638
57STK40.98466729
58EIF2AK30.97767196
59VRK20.97726782
60ATM0.96881209
61MAP3K140.95638478
62LATS10.93950778
63CDK20.93291897
64MAP2K30.93264023
65ICK0.93222525
66NME10.91925897
67PAK40.90633622
68DYRK30.90379055
69PAK20.89020026
70ZAP700.87348694
71PDK20.84469072
72STK240.79098447
73ERBB40.77762442
74PNCK0.74855847
75STK160.74532369
76AURKA0.71503928
77GRK60.69732062
78BMPR20.68568589
79MELK0.68206152
80PTK60.66829139
81FGFR10.66430681
82CHUK0.66085953
83PIM20.65795136
84CDK80.65230633
85PRPF4B0.65223964
86CSNK2A20.65198142
87CDK10.62517084
88BMX0.60082812
89BRAF0.59856274
90MAP3K90.58677376
91MAP3K30.53530609
92TRIM280.53510166
93CSNK1D0.53287132
94CLK10.51464634
95RAF10.51106785
96VRK10.50629343
97TXK0.48844949
98CAMK1G0.48699930
99BTK0.48334747
100* CSNK1E0.46856575
101PAK10.46610765
102STK38L0.46595126
103CAMK1D0.45336922
104MARK30.45156444
105PRKDC0.44900606
106RPS6KA50.44733651
107IKBKB0.43045282
108RPS6KA10.42631058
109AKT20.42497064
110CDK90.42157972
111PDGFRA0.40864323
112ZAK0.40830021
113BRSK10.40478374
114LATS20.40351157
115MAPK140.39599066
116CSNK2A10.39498419
117ITK0.39453852
118MAP3K110.37981300
119ERBB30.37327103
120CCNB10.36983820
121LCK0.35020954
122MAPK10.34667809
123TESK10.33716194
124RPS6KB10.33624382
125MAPKAPK20.33453193
126CSF1R0.33426051
127TYK20.33296797
128NUAK10.32313015
129KSR20.32111689
130IRAK20.28385451
131MET0.28013224
132DMPK0.27297244
133CDK30.27163443
134FGFR40.26393248
135NEK60.25860978

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.84871569
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.84705217
3Mismatch repair_Homo sapiens_hsa034303.36959560
4One carbon pool by folate_Homo sapiens_hsa006703.24869936
5RNA transport_Homo sapiens_hsa030133.23807990
6Spliceosome_Homo sapiens_hsa030403.13447926
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.61130998
8Ribosome_Homo sapiens_hsa030102.49359098
9Cell cycle_Homo sapiens_hsa041102.48613883
10RNA polymerase_Homo sapiens_hsa030202.30730100
11Base excision repair_Homo sapiens_hsa034102.27680568
12Nucleotide excision repair_Homo sapiens_hsa034202.22717393
13Homologous recombination_Homo sapiens_hsa034402.13584542
14mRNA surveillance pathway_Homo sapiens_hsa030152.05928168
15Fanconi anemia pathway_Homo sapiens_hsa034601.81429317
16RNA degradation_Homo sapiens_hsa030181.75477876
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68971083
18p53 signaling pathway_Homo sapiens_hsa041151.66930257
19Non-homologous end-joining_Homo sapiens_hsa034501.66250169
20Pyrimidine metabolism_Homo sapiens_hsa002401.60764721
21Antigen processing and presentation_Homo sapiens_hsa046121.53388349
22Proteasome_Homo sapiens_hsa030501.46300916
23Viral carcinogenesis_Homo sapiens_hsa052031.42479905
24Epstein-Barr virus infection_Homo sapiens_hsa051691.34635973
25Herpes simplex infection_Homo sapiens_hsa051681.31164073
26Basal transcription factors_Homo sapiens_hsa030221.29539705
27Systemic lupus erythematosus_Homo sapiens_hsa053221.26852565
28HTLV-I infection_Homo sapiens_hsa051661.17589811
29MicroRNAs in cancer_Homo sapiens_hsa052061.17271610
30Small cell lung cancer_Homo sapiens_hsa052221.16769343
31Protein export_Homo sapiens_hsa030601.15978464
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.10892242
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08286151
34Chronic myeloid leukemia_Homo sapiens_hsa052201.03680135
35Primary immunodeficiency_Homo sapiens_hsa053401.02210045
36Pyruvate metabolism_Homo sapiens_hsa006200.97811896
37Measles_Homo sapiens_hsa051620.96078287
38Selenocompound metabolism_Homo sapiens_hsa004500.94753855
39Carbon metabolism_Homo sapiens_hsa012000.92862116
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91978941
41Legionellosis_Homo sapiens_hsa051340.90713091
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88966003
43Cyanoamino acid metabolism_Homo sapiens_hsa004600.88421368
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88361480
45Thyroid cancer_Homo sapiens_hsa052160.88298689
46Viral myocarditis_Homo sapiens_hsa054160.87125018
47Apoptosis_Homo sapiens_hsa042100.82848970
48Hepatitis B_Homo sapiens_hsa051610.79556648
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79508835
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79443223
51Acute myeloid leukemia_Homo sapiens_hsa052210.79338281
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77637684
53Biosynthesis of amino acids_Homo sapiens_hsa012300.75156338
54Adherens junction_Homo sapiens_hsa045200.74724663
55T cell receptor signaling pathway_Homo sapiens_hsa046600.74262858
56Notch signaling pathway_Homo sapiens_hsa043300.73454088
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72595324
58Oocyte meiosis_Homo sapiens_hsa041140.71263918
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70877319
60Purine metabolism_Homo sapiens_hsa002300.70290906
61Colorectal cancer_Homo sapiens_hsa052100.69861938
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69560045
63mTOR signaling pathway_Homo sapiens_hsa041500.68639124
64TGF-beta signaling pathway_Homo sapiens_hsa043500.66718119
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.66458328
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66335397
67Hippo signaling pathway_Homo sapiens_hsa043900.63254590
68Leishmaniasis_Homo sapiens_hsa051400.61103197
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61082763
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60985585
71Shigellosis_Homo sapiens_hsa051310.60325746
72Influenza A_Homo sapiens_hsa051640.59801970
73Bladder cancer_Homo sapiens_hsa052190.59357209
74B cell receptor signaling pathway_Homo sapiens_hsa046620.58943764
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.58295298
76Lysine degradation_Homo sapiens_hsa003100.58187490
77Pentose phosphate pathway_Homo sapiens_hsa000300.57964435
78N-Glycan biosynthesis_Homo sapiens_hsa005100.57494031
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57369496
80Toxoplasmosis_Homo sapiens_hsa051450.56170671
81Prostate cancer_Homo sapiens_hsa052150.54803204
82HIF-1 signaling pathway_Homo sapiens_hsa040660.54289875
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.54270732
84Proteoglycans in cancer_Homo sapiens_hsa052050.53487467
85Hematopoietic cell lineage_Homo sapiens_hsa046400.52730173
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.52541301
87Pancreatic cancer_Homo sapiens_hsa052120.51034425
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50493431
89Basal cell carcinoma_Homo sapiens_hsa052170.49823952
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49615951
91Graft-versus-host disease_Homo sapiens_hsa053320.49580575
92Pathways in cancer_Homo sapiens_hsa052000.48816058
93Allograft rejection_Homo sapiens_hsa053300.48715494
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.48601900
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48031557
96Folate biosynthesis_Homo sapiens_hsa007900.46866524
97Steroid biosynthesis_Homo sapiens_hsa001000.46442301
98Renal cell carcinoma_Homo sapiens_hsa052110.45773103
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45698637
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45018249
101TNF signaling pathway_Homo sapiens_hsa046680.42370435
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.42334463
103Non-small cell lung cancer_Homo sapiens_hsa052230.42081117
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41818466
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41265272
106Fatty acid biosynthesis_Homo sapiens_hsa000610.38467233
107Osteoclast differentiation_Homo sapiens_hsa043800.38457017
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37880085
109Asthma_Homo sapiens_hsa053100.34584223
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.34577030
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34426698
112Endometrial cancer_Homo sapiens_hsa052130.34266040
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34035952
114Sulfur relay system_Homo sapiens_hsa041220.33907329
115Vitamin B6 metabolism_Homo sapiens_hsa007500.32949359
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31005940
117Focal adhesion_Homo sapiens_hsa045100.29701933
118Propanoate metabolism_Homo sapiens_hsa006400.28825559
119Fructose and mannose metabolism_Homo sapiens_hsa000510.25765975
120Melanoma_Homo sapiens_hsa052180.23247513
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22525626
122Glioma_Homo sapiens_hsa052140.21509615
123Wnt signaling pathway_Homo sapiens_hsa043100.19525176
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19434850
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18792369
126Alcoholism_Homo sapiens_hsa050340.17669207
127ErbB signaling pathway_Homo sapiens_hsa040120.16640937
128Arginine biosynthesis_Homo sapiens_hsa002200.16098716
129Insulin signaling pathway_Homo sapiens_hsa049100.15636838

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