DDX19B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)8.77473827
2cilium or flagellum-dependent cell motility (GO:0001539)7.39961645
3male meiosis (GO:0007140)6.36152193
4nuclear pore complex assembly (GO:0051292)6.14009475
5nuclear pore organization (GO:0006999)5.92571570
6synaptonemal complex assembly (GO:0007130)5.92262586
7pre-miRNA processing (GO:0031054)5.90577374
8synaptonemal complex organization (GO:0070193)5.75872431
9fusion of sperm to egg plasma membrane (GO:0007342)5.73536509
10axonemal dynein complex assembly (GO:0070286)5.49136553
11DNA methylation involved in gamete generation (GO:0043046)5.43689423
12sperm-egg recognition (GO:0035036)5.36256941
13motile cilium assembly (GO:0044458)5.36043083
14gene silencing by RNA (GO:0031047)5.31939026
15binding of sperm to zona pellucida (GO:0007339)5.28586603
16meiotic nuclear division (GO:0007126)4.90847367
17sperm motility (GO:0030317)4.88434700
18spermatid development (GO:0007286)4.83636571
19chromosome organization involved in meiosis (GO:0070192)4.81710571
20cell-cell recognition (GO:0009988)4.81613990
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.67925234
22acrosome assembly (GO:0001675)4.67803240
23DNA deamination (GO:0045006)4.60575270
24regulation of histone H3-K9 methylation (GO:0051570)4.58330095
25pore complex assembly (GO:0046931)4.50316146
26meiotic cell cycle (GO:0051321)4.49127743
27cullin deneddylation (GO:0010388)4.47946694
28male meiosis I (GO:0007141)4.42091739
29regulation of meiosis I (GO:0060631)4.39810814
30microtubule depolymerization (GO:0007019)4.38284535
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.30019581
32protein deneddylation (GO:0000338)4.28427706
33energy coupled proton transport, down electrochemical gradient (GO:0015985)4.26171287
34ATP synthesis coupled proton transport (GO:0015986)4.26171287
35plasma membrane fusion (GO:0045026)4.22941475
36protein complex biogenesis (GO:0070271)4.22289629
37cell wall macromolecule metabolic process (GO:0044036)4.22193317
38cell wall macromolecule catabolic process (GO:0016998)4.22193317
39acrosome reaction (GO:0007340)4.21076323
40protein neddylation (GO:0045116)4.20690450
41multicellular organism reproduction (GO:0032504)4.18760779
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.18002928
43mitochondrial respiratory chain complex I assembly (GO:0032981)4.18002928
44NADH dehydrogenase complex assembly (GO:0010257)4.18002928
45proteasome assembly (GO:0043248)4.17258346
46monoubiquitinated protein deubiquitination (GO:0035520)4.16438861
47chaperone-mediated protein complex assembly (GO:0051131)4.13911953
48negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.09498681
49regulation of translational termination (GO:0006449)4.07204081
50regulation of cellular amino acid metabolic process (GO:0006521)4.00337604
51gene silencing (GO:0016458)3.99962124
52regulation of centriole replication (GO:0046599)3.99267909
53epithelial cilium movement (GO:0003351)3.99157195
54chaperone-mediated protein transport (GO:0072321)3.99136037
55mitotic sister chromatid cohesion (GO:0007064)3.94365000
56establishment of protein localization to mitochondrial membrane (GO:0090151)3.93339260
57mitochondrial respiratory chain complex assembly (GO:0033108)3.93329093
58negative regulation of histone methylation (GO:0031061)3.85101647
59meiosis I (GO:0007127)3.84379668
60RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.83496892
61tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.83496892
62negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.82891398
63negative regulation of ligase activity (GO:0051352)3.82891398
64DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.82444326
65regulation of RNA export from nucleus (GO:0046831)3.81380101
66positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.76560623
67signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.75884741
68signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.75884741
69signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.75884741
70regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.74289641
71regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.73221495
72signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.71080937
73intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.71080937
74DNA damage response, detection of DNA damage (GO:0042769)3.70836959
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.66920779
76signal transduction involved in cell cycle checkpoint (GO:0072395)3.64565419
77peptidyl-histidine modification (GO:0018202)3.62331698
78respiratory chain complex IV assembly (GO:0008535)3.59724031
79meiotic cell cycle process (GO:1903046)3.59451667
80signal transduction involved in DNA damage checkpoint (GO:0072422)3.59225266
81signal transduction involved in DNA integrity checkpoint (GO:0072401)3.59225266
82mitotic nuclear envelope disassembly (GO:0007077)3.58893863
83DNA replication-dependent nucleosome organization (GO:0034723)3.58845702
84DNA replication-dependent nucleosome assembly (GO:0006335)3.58845702
85mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.58025690
86sister chromatid cohesion (GO:0007062)3.57655684
87reproduction (GO:0000003)3.57396057
88heterochromatin organization (GO:0070828)3.56383478
89protein targeting to mitochondrion (GO:0006626)3.53402432
90pseudouridine synthesis (GO:0001522)3.51245069
91respiratory electron transport chain (GO:0022904)3.51115805
92negative regulation of DNA repair (GO:0045738)3.50558774
93regulation of posttranscriptional gene silencing (GO:0060147)3.50279149
94regulation of gene silencing by miRNA (GO:0060964)3.50279149
95regulation of gene silencing by RNA (GO:0060966)3.50279149
96histone H2A monoubiquitination (GO:0035518)3.49115548
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.48634054
98electron transport chain (GO:0022900)3.48165287
99nuclear envelope disassembly (GO:0051081)3.44677247
100membrane disassembly (GO:0030397)3.44677247
101regulation of translational fidelity (GO:0006450)3.41765536
102mitotic sister chromatid segregation (GO:0000070)3.41051132
103anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.39288613
104folic acid-containing compound biosynthetic process (GO:0009396)3.37653335
105spliceosomal snRNP assembly (GO:0000387)3.37270544
106protein localization to chromosome, centromeric region (GO:0071459)3.36588618
107inner mitochondrial membrane organization (GO:0007007)3.36246619
108sister chromatid segregation (GO:0000819)3.35532905
109deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.34266194
110cytochrome complex assembly (GO:0017004)3.33676314
111cilium movement (GO:0003341)3.32404461
112regulation of translation, ncRNA-mediated (GO:0045974)3.32240531
113negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.32240531
114negative regulation of translation, ncRNA-mediated (GO:0040033)3.32240531
115DNA catabolic process, exonucleolytic (GO:0000738)3.31786980
116establishment of protein localization to mitochondrion (GO:0072655)3.29948072
117negative regulation of organelle assembly (GO:1902116)3.29461892
118regulation of mitochondrial translation (GO:0070129)3.26945733
119deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.26910580
120protein localization to mitochondrion (GO:0070585)3.25395425
121germ cell development (GO:0007281)3.24633333
122oxidative phosphorylation (GO:0006119)3.24436700
123positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.24060183
124L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.23408420
125tRNA aminoacylation (GO:0043039)3.22656744
126amino acid activation (GO:0043038)3.22656744
127regulation of centrosome cycle (GO:0046605)3.21732544
128protein localization to kinetochore (GO:0034501)3.21407343
129water-soluble vitamin biosynthetic process (GO:0042364)3.21372100
130translesion synthesis (GO:0019985)3.21196988
131spindle assembly involved in mitosis (GO:0090307)3.20520206
132regulation of nucleobase-containing compound transport (GO:0032239)3.20265605
133nucleus organization (GO:0006997)3.19255984
134tRNA aminoacylation for protein translation (GO:0006418)3.19003489
135rRNA modification (GO:0000154)3.17571119
136regulation of chromatin binding (GO:0035561)3.15394553
137DNA methylation (GO:0006306)3.15170635
138DNA alkylation (GO:0006305)3.15170635
139purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.12667458
140ribosome assembly (GO:0042255)3.12622439
141spermatogenesis (GO:0007283)3.11176762
142DNA double-strand break processing (GO:0000729)3.11176180
143male gamete generation (GO:0048232)3.10819018
144negative regulation of inclusion body assembly (GO:0090084)3.10535621
145histone exchange (GO:0043486)3.09960449
146regulation of protein polyubiquitination (GO:1902914)3.09906148
1477-methylguanosine mRNA capping (GO:0006370)3.07871473
148tRNA processing (GO:0008033)3.06765942
149positive regulation of ligase activity (GO:0051351)3.06688362
150mRNA cleavage (GO:0006379)3.06386292
151tRNA metabolic process (GO:0006399)3.06241361
152DNA geometric change (GO:0032392)3.05041779
153DNA duplex unwinding (GO:0032508)3.03597931
154metallo-sulfur cluster assembly (GO:0031163)3.03530348
155iron-sulfur cluster assembly (GO:0016226)3.03530348
156ribosomal small subunit assembly (GO:0000028)3.03183837
157aldehyde catabolic process (GO:0046185)3.03140499
158protein K6-linked ubiquitination (GO:0085020)3.02830492
159NLS-bearing protein import into nucleus (GO:0006607)3.01774289
160chromosome condensation (GO:0030261)3.01757539
161protein-cofactor linkage (GO:0018065)3.01378047
162GMP metabolic process (GO:0046037)3.00922772
163transcription elongation from RNA polymerase III promoter (GO:0006385)3.00570071
164termination of RNA polymerase III transcription (GO:0006386)3.00570071
165synapsis (GO:0007129)2.98211853
166purine nucleobase biosynthetic process (GO:0009113)2.97890204
167mitotic chromosome condensation (GO:0007076)2.97624747
168RNA capping (GO:0036260)2.97595217
1697-methylguanosine RNA capping (GO:0009452)2.97595217
170regulation of ubiquitin-protein transferase activity (GO:0051438)2.96764094
171cellular process involved in reproduction in multicellular organism (GO:0022412)2.96713155
172glycine metabolic process (GO:0006544)2.96600925
173somatic diversification of immune receptors via somatic mutation (GO:0002566)2.94161371
174somatic hypermutation of immunoglobulin genes (GO:0016446)2.94161371
175organelle disassembly (GO:1903008)2.92949541
176reciprocal meiotic recombination (GO:0007131)2.92640434
177reciprocal DNA recombination (GO:0035825)2.92640434
178formation of translation preinitiation complex (GO:0001731)2.92244063
179positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.90995084
180regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.90995084
181DNA packaging (GO:0006323)2.90574053
182regulation of helicase activity (GO:0051095)2.89664191
183establishment of integrated proviral latency (GO:0075713)2.87386780
184transcription-coupled nucleotide-excision repair (GO:0006283)2.87290825
185cellular component biogenesis (GO:0044085)2.86934332
186DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.85796119
187branched-chain amino acid catabolic process (GO:0009083)2.85110683
188antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.84429120
189histone H2A acetylation (GO:0043968)2.83463581
190regulation of cellular amine metabolic process (GO:0033238)2.83286114
191regulation of ligase activity (GO:0051340)2.83265446
192ribonucleoprotein complex disassembly (GO:0032988)2.81451835
193translation (GO:0006412)2.80831102
194ubiquinone biosynthetic process (GO:0006744)2.80413498
195positive regulation of cell cycle arrest (GO:0071158)2.79788866
196pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.78472355
197ribosomal large subunit biogenesis (GO:0042273)2.78119074
198negative regulation of protein ubiquitination (GO:0031397)2.75623511
199mannosylation (GO:0097502)2.74650832
200negative regulation of telomere maintenance (GO:0032205)2.74562609

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.27694337
2E2F7_22180533_ChIP-Seq_HELA_Human6.94882076
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.24929860
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.04512177
5GABP_17652178_ChIP-ChIP_JURKAT_Human4.79398341
6FOXM1_23109430_ChIP-Seq_U2OS_Human4.75421170
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.29047610
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.15286239
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.54224560
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.06292771
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.05161570
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.90553944
13ELK1_19687146_ChIP-ChIP_HELA_Human2.70847205
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.66576238
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.57554940
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.55485362
17* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.44035756
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32393095
19DCP1A_22483619_ChIP-Seq_HELA_Human2.30058555
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.25760993
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.25402288
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.20150394
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12166570
24MYCN_18555785_ChIP-Seq_MESCs_Mouse2.11298232
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.10415428
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.08911910
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.08313768
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05324888
29HOXB4_20404135_ChIP-ChIP_EML_Mouse1.97915266
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94773130
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92843342
32TTF2_22483619_ChIP-Seq_HELA_Human1.86671026
33AR_21909140_ChIP-Seq_LNCAP_Human1.84562308
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82481819
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79257500
36* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.75368119
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73930321
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67599121
39MYC_18940864_ChIP-ChIP_HL60_Human1.67096741
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.65505745
41ZNF274_21170338_ChIP-Seq_K562_Hela1.65368467
42* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63317144
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.61116565
44KLF4_18555785_ChIP-Seq_MESCs_Mouse1.54484629
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.54102977
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.53805900
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50328374
48CIITA_25753668_ChIP-Seq_RAJI_Human1.49579379
49MYC_22102868_ChIP-Seq_BL_Human1.48107375
50* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45291675
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43032863
52KDM5A_27292631_Chip-Seq_BREAST_Human1.40792260
53ELK4_26923725_Chip-Seq_MESODERM_Mouse1.39783656
54BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.38928975
55NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.37774221
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35262341
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34752184
58* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31761174
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28596190
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26229905
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24060824
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22463178
63XRN2_22483619_ChIP-Seq_HELA_Human1.20692935
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20556081
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18304222
66NANOG_21062744_ChIP-ChIP_HESCs_Human1.18145525
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17937785
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16737786
69HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15357477
70* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14855817
71GABP_19822575_ChIP-Seq_HepG2_Human1.12073885
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10672627
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10441427
74RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10302387
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.09681812
76CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09533871
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08950598
78FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08800776
79IGF1R_20145208_ChIP-Seq_DFB_Human1.08667420
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07937333
81FOXP3_21729870_ChIP-Seq_TREG_Human1.07101318
82CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.06757607
83IRF1_19129219_ChIP-ChIP_H3396_Human1.06170573
84ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05572547
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05495937
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04807671
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.04161518
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04026043
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01590465
90STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01471667
91* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00560671
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99918524
93* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99477795
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98962019
95GATA1_26923725_Chip-Seq_HPCs_Mouse0.98800917
96VDR_23849224_ChIP-Seq_CD4+_Human0.97959246
97EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.97762547
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95438557
99ZNF263_19887448_ChIP-Seq_K562_Human0.94847526
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93221974
101* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92324978
102PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91947763
103KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90699403
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90699403
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90699403
106CREB1_15753290_ChIP-ChIP_HEK293T_Human0.90428194
107NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90395217
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88520020
109ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85755819
110* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.84945724
111TFEB_21752829_ChIP-Seq_HELA_Human0.84753793
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83238143
113SOX2_16153702_ChIP-ChIP_HESCs_Human0.82975833
114POU5F1_16518401_ChIP-PET_MESCs_Mouse0.82741780
115TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82714954
116* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.82551343
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81518489
118LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.80827612
119NANOG_16153702_ChIP-ChIP_HESCs_Human0.80266118
120FLI1_27457419_Chip-Seq_LIVER_Mouse0.79958782
121RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.79823959
122SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79552423
123YY1_21170310_ChIP-Seq_MESCs_Mouse0.79377596
124RXRA_24833708_ChIP-Seq_LIVER_Mouse0.79288956
125* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79267712
126TCF7_22412390_ChIP-Seq_EML_Mouse0.78917558
127FOXP1_21924763_ChIP-Seq_HESCs_Human0.78807827
128RARA_24833708_ChIP-Seq_LIVER_Mouse0.78775422
129ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.77978441
130KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77716727
131TP53_22573176_ChIP-Seq_HFKS_Human0.77654384
132PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76899170
133EST1_17652178_ChIP-ChIP_JURKAT_Human0.76478864
134* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.76287497
135CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75779779
136GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.75001892
137CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.73024094
138WDR5_24793694_ChIP-Seq_LNCAP_Human0.73003256
139ETS1_20019798_ChIP-Seq_JURKAT_Human0.70890646
140KAP1_27257070_Chip-Seq_ESCs_Mouse0.70710059
141SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.70666113
142NANOG_16518401_ChIP-PET_MESCs_Mouse0.70645606
143EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.70558452
144KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.70288558
145CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.70011642
146AR_20517297_ChIP-Seq_VCAP_Human0.69732021
147NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.69667699
148MYB_26560356_Chip-Seq_TH1_Human0.69311418
149NOTCH1_21737748_ChIP-Seq_TLL_Human0.68749937
150SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.67469009
151EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.67379869
152HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.67306213
153PHF8_20622854_ChIP-Seq_HELA_Human0.66734318
154ELF5_23300383_ChIP-Seq_T47D_Human0.65453880
155SPI1_23547873_ChIP-Seq_NB4_Human0.65116464
156CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.65096555

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.08687028
2MP0008877_abnormal_DNA_methylation4.62152734
3MP0010094_abnormal_chromosome_stability4.11943430
4MP0001929_abnormal_gametogenesis3.55035315
5MP0008057_abnormal_DNA_replication3.53450710
6MP0003111_abnormal_nucleus_morphology3.48524910
7MP0002102_abnormal_ear_morphology3.43058177
8MP0002653_abnormal_ependyma_morphology3.40729010
9MP0003698_abnormal_male_reproductive3.25101872
10MP0006036_abnormal_mitochondrial_physio2.99323194
11MP0008789_abnormal_olfactory_epithelium2.95380939
12MP0010307_abnormal_tumor_latency2.83364325
13MP0002210_abnormal_sex_determination2.81015548
14MP0003693_abnormal_embryo_hatching2.80227658
15MP0003077_abnormal_cell_cycle2.74886424
16MP0005394_taste/olfaction_phenotype2.65698411
17MP0005499_abnormal_olfactory_system2.65698411
18MP0008058_abnormal_DNA_repair2.65606100
19MP0004957_abnormal_blastocyst_morpholog2.61986622
20MP0003186_abnormal_redox_activity2.61845581
21MP0001145_abnormal_male_reproductive2.55972374
22MP0003890_abnormal_embryonic-extraembry2.53859448
23MP0001529_abnormal_vocalization2.51401962
24MP0001730_embryonic_growth_arrest2.35911634
25MP0010352_gastrointestinal_tract_polyps2.27397757
26MP0000653_abnormal_sex_gland2.21838686
27MP0003122_maternal_imprinting2.17132413
28MP0006072_abnormal_retinal_apoptosis2.07386889
29MP0003787_abnormal_imprinting2.06127126
30MP0001984_abnormal_olfaction1.98052878
31MP0002139_abnormal_hepatobiliary_system1.97508094
32MP0002254_reproductive_system_inflammat1.96592590
33MP0002161_abnormal_fertility/fecundity1.94500551
34MP0005076_abnormal_cell_differentiation1.93045166
35MP0001672_abnormal_embryogenesis/_devel1.90829344
36MP0005380_embryogenesis_phenotype1.90829344
37MP0003705_abnormal_hypodermis_morpholog1.80959402
38MP0001764_abnormal_homeostasis1.76648025
39MP0003806_abnormal_nucleotide_metabolis1.76100629
40MP0000350_abnormal_cell_proliferation1.75564492
41MP0006292_abnormal_olfactory_placode1.75375391
42MP0003011_delayed_dark_adaptation1.72703324
43MP0002084_abnormal_developmental_patter1.72164530
44MP0003984_embryonic_growth_retardation1.70649141
45MP0001697_abnormal_embryo_size1.68667090
46MP0002088_abnormal_embryonic_growth/wei1.68073949
47MP0008007_abnormal_cellular_replicative1.67606991
48MP0004147_increased_porphyrin_level1.67541484
49MP0004197_abnormal_fetal_growth/weight/1.64281624
50MP0002132_abnormal_respiratory_system1.62248822
51MP0002086_abnormal_extraembryonic_tissu1.58316878
52MP0000372_irregular_coat_pigmentation1.52665156
53MP0002080_prenatal_lethality1.41919944
54MP0004808_abnormal_hematopoietic_stem1.41216085
55MP0002085_abnormal_embryonic_tissue1.39110395
56MP0003121_genomic_imprinting1.38623059
57MP0005085_abnormal_gallbladder_physiolo1.37264747
58MP0003786_premature_aging1.36664262
59MP0006276_abnormal_autonomic_nervous1.36502243
60MP0009672_abnormal_birth_weight1.35411279
61MP0003123_paternal_imprinting1.34317315
62MP0005365_abnormal_bile_salt1.33026873
63MP0005253_abnormal_eye_physiology1.30074581
64MP0005623_abnormal_meninges_morphology1.29549352
65MP0005645_abnormal_hypothalamus_physiol1.28649283
66MP0002163_abnormal_gland_morphology1.24101230
67MP0002269_muscular_atrophy1.21816213
68MP0002160_abnormal_reproductive_system1.21535957
69MP0009697_abnormal_copulation1.20929309
70MP0000358_abnormal_cell_content/1.20333684
71MP0009703_decreased_birth_body1.17858768
72MP0010234_abnormal_vibrissa_follicle1.17680256
73MP0004233_abnormal_muscle_weight1.17597113
74MP0005075_abnormal_melanosome_morpholog1.16662450
75MP0002277_abnormal_respiratory_mucosa1.13012650
76MP0003119_abnormal_digestive_system1.10260257
77MP0005084_abnormal_gallbladder_morpholo1.10235417
78MP0001919_abnormal_reproductive_system1.09832985
79MP0003567_abnormal_fetal_cardiomyocyte1.09121520
80MP0002233_abnormal_nose_morphology1.08469508
81MP0004130_abnormal_muscle_cell1.06725488
82MP0005451_abnormal_body_composition1.06211151
83MP0000313_abnormal_cell_death1.06146906
84MP0008932_abnormal_embryonic_tissue1.05050935
85MP0003252_abnormal_bile_duct1.04891694
86MP0005360_urolithiasis1.04442290
87MP0001986_abnormal_taste_sensitivity1.04172427
88MP0004264_abnormal_extraembryonic_tissu1.03155836
89MP0004185_abnormal_adipocyte_glucose0.98317496
90MP0008872_abnormal_physiological_respon0.96298657
91MP0000609_abnormal_liver_physiology0.95347815
92MP0002019_abnormal_tumor_incidence0.95344917
93MP0001293_anophthalmia0.95332715
94MP0005551_abnormal_eye_electrophysiolog0.94541334
95MP0005666_abnormal_adipose_tissue0.92129482
96MP0002837_dystrophic_cardiac_calcinosis0.90548534
97MP0002751_abnormal_autonomic_nervous0.90475403
98MP0010329_abnormal_lipoprotein_level0.90425144
99MP0002938_white_spotting0.87346295
100MP0002876_abnormal_thyroid_physiology0.85285742
101MP0008961_abnormal_basal_metabolism0.84940705
102MP0001542_abnormal_bone_strength0.84327842
103MP0001286_abnormal_eye_development0.83346794
104MP0001727_abnormal_embryo_implantation0.82836247
105MP0001188_hyperpigmentation0.82181488
106MP0009333_abnormal_splenocyte_physiolog0.82124638
107MP0005391_vision/eye_phenotype0.81900542
108MP0001661_extended_life_span0.81032072
109MP0003646_muscle_fatigue0.80895107
110MP0003195_calcinosis0.80841295
111MP0001905_abnormal_dopamine_level0.79302606
112MP0005501_abnormal_skin_physiology0.78400484
113MP0005389_reproductive_system_phenotype0.78333537
114MP0000015_abnormal_ear_pigmentation0.78083647
115MP0003315_abnormal_perineum_morphology0.77752374
116MP0009840_abnormal_foam_cell0.77128993
117MP0003221_abnormal_cardiomyocyte_apopto0.77036619
118MP0003699_abnormal_female_reproductive0.75767734
119MP0001915_intracranial_hemorrhage0.75100212
120MP0009765_abnormal_xenobiotic_induced0.74904470
121MP0000747_muscle_weakness0.74189527
122MP0001849_ear_inflammation0.73879376
123MP0009046_muscle_twitch0.73651150
124MP0003861_abnormal_nervous_system0.71719162
125MP0000703_abnormal_thymus_morphology0.70310028
126MP0003115_abnormal_respiratory_system0.68718397
127MP0003718_maternal_effect0.68378957
128MP0004133_heterotaxia0.68063299
129MP0005384_cellular_phenotype0.67843435
130MP0001853_heart_inflammation0.67426603
131MP0005266_abnormal_metabolism0.67326603
132MP0005332_abnormal_amino_acid0.67149105
133MP0002971_abnormal_brown_adipose0.66955396
134MP0003656_abnormal_erythrocyte_physiolo0.65671563
135MP0005408_hypopigmentation0.65387856
136MP0005636_abnormal_mineral_homeostasis0.65254619
137MP0001119_abnormal_female_reproductive0.64866468
138MP0003632_abnormal_nervous_system0.64864623
139MP0005670_abnormal_white_adipose0.64410629
140MP0008875_abnormal_xenobiotic_pharmacok0.64088916
141MP0000049_abnormal_middle_ear0.63185821
142MP0000631_abnormal_neuroendocrine_gland0.63047076
143MP0009764_decreased_sensitivity_to0.62978053
144MP0002095_abnormal_skin_pigmentation0.62284578
145MP0002877_abnormal_melanocyte_morpholog0.62101779
146MP0003880_abnormal_central_pattern0.61472535
147MP0000689_abnormal_spleen_morphology0.61307461
148MP0005621_abnormal_cell_physiology0.61057495
149MP0004142_abnormal_muscle_tone0.60884571
150MP0003941_abnormal_skin_development0.60733113
151MP0002092_abnormal_eye_morphology0.60576544
152MP0000598_abnormal_liver_morphology0.59853467
153MP0008995_early_reproductive_senescence0.59290917
154MP0002970_abnormal_white_adipose0.59154743
155MP0006035_abnormal_mitochondrial_morpho0.58993552
156MP0000569_abnormal_digit_pigmentation0.57614907
157MP0003936_abnormal_reproductive_system0.56379928
158MP0000428_abnormal_craniofacial_morphol0.55520980
159MP0002697_abnormal_eye_size0.55220622
160MP0008770_decreased_survivor_rate0.51693891
161MP0005187_abnormal_penis_morphology0.51599843
162MP0002396_abnormal_hematopoietic_system0.50349583
163MP0001545_abnormal_hematopoietic_system0.49470179
164MP0005397_hematopoietic_system_phenotyp0.49470179

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.49648094
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.45570178
3Absent/shortened dynein arms (HP:0200106)6.45570178
4Hyperacusis (HP:0010780)5.26191618
5Abnormal respiratory motile cilium physiology (HP:0012261)5.18246993
6Rhinitis (HP:0012384)5.09350374
7Renovascular hypertension (HP:0100817)5.02126484
8Abnormal respiratory epithelium morphology (HP:0012253)4.83888203
9Abnormal respiratory motile cilium morphology (HP:0005938)4.83888203
10Acute necrotizing encephalopathy (HP:0006965)4.80714603
11Elfin facies (HP:0004428)4.77303134
12Abnormal mitochondria in muscle tissue (HP:0008316)4.55227233
13Overriding aorta (HP:0002623)4.52974356
14Chronic bronchitis (HP:0004469)4.51534158
15Acute encephalopathy (HP:0006846)4.48444358
16Mitochondrial inheritance (HP:0001427)4.43882913
17Abnormality of the lower motor neuron (HP:0002366)4.37167302
18Hepatocellular necrosis (HP:0001404)4.28799099
19Nasal polyposis (HP:0100582)4.17798276
20Increased CSF lactate (HP:0002490)4.14741161
21Hepatic necrosis (HP:0002605)4.09586685
22Decreased activity of mitochondrial respiratory chain (HP:0008972)4.04150323
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.04150323
24Insomnia (HP:0100785)3.95328129
25Renal duplication (HP:0000075)3.88621266
26Progressive macrocephaly (HP:0004481)3.80788746
27Toxemia of pregnancy (HP:0100603)3.80142592
28Abnormal ciliary motility (HP:0012262)3.75909789
29Increased nuchal translucency (HP:0010880)3.64190198
30Increased hepatocellular lipid droplets (HP:0006565)3.54533606
31Lipid accumulation in hepatocytes (HP:0006561)3.49493376
32Flat cornea (HP:0007720)3.44107552
33Cerebral edema (HP:0002181)3.42901198
34Increased serum pyruvate (HP:0003542)3.40498623
35Abnormality of the diencephalon (HP:0010662)3.35303591
36Infertility (HP:0000789)3.32404043
37Hyperglycinemia (HP:0002154)3.32351966
38Ependymoma (HP:0002888)3.31194023
39Methylmalonic aciduria (HP:0012120)3.28465588
40Increased serum lactate (HP:0002151)3.27373958
41Lactic acidosis (HP:0003128)3.23571682
42Impulsivity (HP:0100710)3.22470441
43Increased intramyocellular lipid droplets (HP:0012240)3.16693540
44Methylmalonic acidemia (HP:0002912)3.15037030
45Type I transferrin isoform profile (HP:0003642)3.14303400
46Abnormality of the nasal mucosa (HP:0000433)3.12739176
47Abnormality of glycolysis (HP:0004366)3.11185046
48Abnormal protein glycosylation (HP:0012346)3.03370391
49Abnormal glycosylation (HP:0012345)3.03370391
50Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.03370391
51Abnormal protein N-linked glycosylation (HP:0012347)3.03370391
52Sensory axonal neuropathy (HP:0003390)2.99046627
53Aplastic anemia (HP:0001915)2.86388158
54Heterotopia (HP:0002282)2.85820927
55Abnormality of the carotid arteries (HP:0005344)2.85649807
56Polygenic inheritance (HP:0010982)2.84241516
57Bronchiectasis (HP:0002110)2.83833920
58Renal Fanconi syndrome (HP:0001994)2.83495655
59Increased muscle lipid content (HP:0009058)2.78179810
60Microvesicular hepatic steatosis (HP:0001414)2.75358118
61Abnormal number of erythroid precursors (HP:0012131)2.72413173
62Bowel diverticulosis (HP:0005222)2.72267866
63Exercise intolerance (HP:0003546)2.69495747
64Bronchitis (HP:0012387)2.66929105
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.65530821
66Dicarboxylic aciduria (HP:0003215)2.65530821
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.62213660
683-Methylglutaconic aciduria (HP:0003535)2.61569565
69Amyotrophic lateral sclerosis (HP:0007354)2.61014603
70Curly hair (HP:0002212)2.60089361
71Respiratory failure (HP:0002878)2.59414449
72Astrocytoma (HP:0009592)2.59025896
73Abnormality of the astrocytes (HP:0100707)2.59025896
74Nephronophthisis (HP:0000090)2.56599178
75Upper motor neuron abnormality (HP:0002127)2.54153636
76Abnormality of cells of the erythroid lineage (HP:0012130)2.53262117
77Lethargy (HP:0001254)2.52252668
78Hyporeflexia of lower limbs (HP:0002600)2.45207658
79Pancytopenia (HP:0001876)2.44338532
80Megalocornea (HP:0000485)2.44169574
81Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.42899609
82True hermaphroditism (HP:0010459)2.42890667
83Medulloblastoma (HP:0002885)2.37562204
84Neonatal respiratory distress (HP:0002643)2.37181072
85Reduced antithrombin III activity (HP:0001976)2.35541586
86Abnormality of methionine metabolism (HP:0010901)2.34768150
87Emotional lability (HP:0000712)2.33485441
88Abnormality of serum amino acid levels (HP:0003112)2.25177587
89Abnormal spermatogenesis (HP:0008669)2.20712097
90Gonadotropin excess (HP:0000837)2.20268707
91Biliary tract neoplasm (HP:0100574)2.19710369
92Recurrent otitis media (HP:0000403)2.18254078
93Abnormality of the anterior horn cell (HP:0006802)2.17285044
94Degeneration of anterior horn cells (HP:0002398)2.17285044
95Abnormality of aspartate family amino acid metabolism (HP:0010899)2.17004220
96Obsessive-compulsive behavior (HP:0000722)2.13675867
97CNS demyelination (HP:0007305)2.13610887
98Pancreatic cysts (HP:0001737)2.13402421
99Optic disc pallor (HP:0000543)2.12891745
100Ragged-red muscle fibers (HP:0003200)2.11003872
101Neoplasm of the adrenal gland (HP:0100631)2.10567274
102Prominent nose (HP:0000448)2.08848004
103Abnormality of serine family amino acid metabolism (HP:0010894)2.08337847
104Abnormality of glycine metabolism (HP:0010895)2.08337847
105Glioma (HP:0009733)2.08156632
106Abnormality of the ileum (HP:0001549)2.08139240
107Prominent metopic ridge (HP:0005487)2.07908319
108Pointed chin (HP:0000307)2.07472382
109Abnormality of renal resorption (HP:0011038)2.07138251
110Exertional dyspnea (HP:0002875)2.05372302
111Meckel diverticulum (HP:0002245)2.04984615
112Neoplasm of the oral cavity (HP:0100649)2.04365708
113Areflexia of lower limbs (HP:0002522)2.04174313
114Chromsome breakage (HP:0040012)2.03974155
115Abnormal biliary tract physiology (HP:0012439)2.03816927
116Bile duct proliferation (HP:0001408)2.03816927
117Nephrogenic diabetes insipidus (HP:0009806)2.02195824
118Sandal gap (HP:0001852)1.98803944
119Abnormality of ocular smooth pursuit (HP:0000617)1.98216512
120Pancreatic fibrosis (HP:0100732)1.97716426
121Morphological abnormality of the pyramidal tract (HP:0002062)1.97548016
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97450525
123Azoospermia (HP:0000027)1.97346822
124Rhabdomyosarcoma (HP:0002859)1.97269261
125Medial flaring of the eyebrow (HP:0010747)1.97130246
126Tubular atrophy (HP:0000092)1.96203077
127Bladder diverticulum (HP:0000015)1.95924391
128Abnormality of alanine metabolism (HP:0010916)1.94698168
129Hyperalaninemia (HP:0003348)1.94698168
130Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94698168
131Atrophy/Degeneration involving motor neurons (HP:0007373)1.92898580
132Respiratory difficulties (HP:0002880)1.92565234
133Abnormality of the metopic suture (HP:0005556)1.90367478
134Hypoplastic toenails (HP:0001800)1.89932785
135Papillary thyroid carcinoma (HP:0002895)1.88235851
136Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87356380
137Abnormality of the vitamin B12 metabolism (HP:0004341)1.87038684
138Type 2 muscle fiber atrophy (HP:0003554)1.86984185
139Male infertility (HP:0003251)1.85580543
140IgM deficiency (HP:0002850)1.85551979
141Recurrent sinusitis (HP:0011108)1.85179862
142Macrocytic anemia (HP:0001972)1.84927624
143Abnormality of chromosome stability (HP:0003220)1.83352380
144Absent thumb (HP:0009777)1.81404140
145Hyperglycinuria (HP:0003108)1.81063520
146Basal cell carcinoma (HP:0002671)1.79438612
147Upper limb muscle weakness (HP:0003484)1.78619046
148Glycosuria (HP:0003076)1.78011132
149Abnormality of urine glucose concentration (HP:0011016)1.78011132
150Cellular immunodeficiency (HP:0005374)1.77841875
151Neoplasm of striated muscle (HP:0009728)1.77531691
152Facial hemangioma (HP:0000329)1.77065877
153Abnormality of the renal medulla (HP:0100957)1.75630233
154Missing ribs (HP:0000921)1.75431456
155CNS hypomyelination (HP:0003429)1.75259410
156Pendular nystagmus (HP:0012043)1.75055828
157Sloping forehead (HP:0000340)1.74936357
158Leukodystrophy (HP:0002415)1.74660950
159Agnosia (HP:0010524)1.74418933
160Abnormality of vitamin B metabolism (HP:0004340)1.73334232
161Hypoplastic pelvis (HP:0008839)1.71884002
162Abnormality of pyrimidine metabolism (HP:0004353)1.71825705
163Pseudobulbar signs (HP:0002200)1.71380327
164Dry hair (HP:0011359)1.71250605
165Adrenal hypoplasia (HP:0000835)1.70933996
166Generalized aminoaciduria (HP:0002909)1.70016582
167Aplasia/hypoplasia of the uterus (HP:0008684)1.69649559
168Lissencephaly (HP:0001339)1.69412408
169Supernumerary spleens (HP:0009799)1.68579486
170Postnatal microcephaly (HP:0005484)1.68548368
171Rough bone trabeculation (HP:0100670)1.68234381
172Aplasia/Hypoplasia of the uvula (HP:0010293)1.68090245
173Colon cancer (HP:0003003)1.67913341
174Hypopigmentation of the fundus (HP:0007894)1.66765623
175Congenital primary aphakia (HP:0007707)1.66566738
176Selective tooth agenesis (HP:0001592)1.66485041
177Patellar dislocation (HP:0002999)1.64156753
178Abnormal biliary tract morphology (HP:0012440)1.63390896
179Polycystic kidney dysplasia (HP:0000113)1.61507355
18011 pairs of ribs (HP:0000878)1.58663149
181Spastic diplegia (HP:0001264)1.57579199
182Overlapping toe (HP:0001845)1.56978715
183Cafe-au-lait spot (HP:0000957)1.56963353
184Spastic tetraparesis (HP:0001285)1.56827665
185Hand muscle atrophy (HP:0009130)1.55514197
186Abnormality of the labia minora (HP:0012880)1.55091434
187Breast carcinoma (HP:0003002)1.53548703
188Impaired smooth pursuit (HP:0007772)1.52996545
189Short humerus (HP:0005792)1.50673617
190Abnormality of the preputium (HP:0100587)1.49636319
191Chronic sinusitis (HP:0011109)1.49567654
192Attention deficit hyperactivity disorder (HP:0007018)1.49128638
193Short ribs (HP:0000773)1.48268589
194Abnormality of the gastric mucosa (HP:0004295)1.48173652

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.45953054
2PDK46.45953054
3VRK25.11079443
4PDK23.77913200
5STK163.39046676
6BCKDK3.20371182
7NEK23.19173415
8MAP4K23.08572474
9ZAK3.03422362
10CDK123.01033612
11CDC72.91435523
12MST42.73641674
13TRIM282.66874703
14MAP3K92.59159688
15NUAK12.56168376
16VRK12.31809322
17NEK12.22151895
18PRKD32.18971477
19BCR2.18323578
20PNCK2.16032973
21TTK2.07475051
22CSNK1G32.07439971
23NME21.98363283
24EIF2AK31.88150154
25WEE11.87669767
26CSNK1A1L1.81447816
27TESK11.79555244
28CSNK1G11.77178829
29TLK11.75515373
30BMPR1B1.72449058
31PASK1.67563170
32ICK1.66647403
33DYRK21.62299167
34EEF2K1.61640373
35CSNK1G21.52481117
36AKT31.52353331
37STK31.46597631
38CDK81.46360339
39TAOK31.45411380
40ALK1.36103039
41EPHA21.35391043
42SCYL21.32946679
43PINK11.32402445
44RIPK11.28792003
45LIMK11.27325809
46CHEK21.27034425
47ATR1.23966073
48CDK41.21900278
49SRPK11.19903021
50* CHEK11.19429444
51SIK31.18834944
52PLK11.17828971
53TXK1.17032599
54MTOR1.15898713
55MAP3K101.15091097
56WNK31.14877535
57TSSK61.12472666
58PKN21.11330415
59KDR1.09904912
60PBK1.05269474
61TAF11.04102960
62CDK191.02796981
63ADRBK21.01754753
64MAP2K71.01491545
65RPS6KA41.00139708
66STK380.98414827
67NME10.96979301
68BRD40.96752062
69YES10.96600091
70ATM0.94886951
71MKNK10.94343806
72PDGFRB0.92823101
73BUB10.89809309
74CDK70.89749683
75EIF2AK10.89628467
76TAOK10.89098989
77CDK60.87211212
78STK100.86565791
79LATS10.85856313
80RPS6KA50.85848785
81AURKB0.85639526
82PIM20.85585639
83GRK70.80932767
84TRIB30.80477383
85FLT30.78562695
86GRK10.77723129
87TESK20.77557810
88MAP3K80.73814388
89PLK30.73197495
90CDK20.73193547
91BRSK20.73073848
92DAPK10.72873716
93TYRO30.70422989
94PIK3CA0.70246162
95RPS6KB20.67668363
96EIF2AK20.67227699
97CCNB10.67207878
98CSNK2A10.64402984
99MUSK0.62508421
100CSNK1D0.62311087
101LATS20.59022304
102CDK10.58918412
103STK40.58900212
104TYK20.55065874
105PDK10.53828484
106FGFR40.52724438
107ERBB30.52685820
108INSRR0.50667527
109MINK10.50548526
110IKBKB0.50393456
111MELK0.49806320
112PLK40.49594890
113PLK20.47094222
114KSR20.46530562
115MAP3K40.46114047
116ACVR1B0.46011612
117FRK0.45618089
118MAP3K50.44828994
119MAPK100.44827910
120OXSR10.44524020
121DYRK30.43188935
122SGK30.42558725
123CSNK1E0.42321060
124STK38L0.41588688
125AURKA0.41193921
126MAP4K10.40983277
127PRKDC0.40781972
128PTK2B0.40681827
129MAP3K120.40395708
130EGFR0.39994747
131CSNK1A10.39915323
132IKBKE0.39861999
133PRKAA10.39784417
134CLK10.39782215
135PAK30.37133046
136MAP3K20.34168208
137DYRK1B0.34037336
138BRSK10.33977415
139PTK60.33574677
140CDK90.33074811
141PRKCI0.32779264
142GRK50.32508435
143GSK3B0.31661451
144TIE10.31609452
145CSNK2A20.30316936
146RPS6KB10.29641587
147MAP2K30.29394860
148PDGFRA0.29320209
149CAMKK10.28725806
150MARK30.28110233
151PAK60.27865851
152DAPK30.27280775
153RET0.26861636
154CAMK1G0.26763560
155MATK0.26022248
156WNK10.25817030
157CDK140.25386792
158MET0.25345711
159ZAP700.25338828
160CAMKK20.24554847
161PIM10.23594160
162MAPK140.23577458
163MAP2K20.23373396
164MAPK80.22378390
165HCK0.22376351
166PAK10.22259546
167ABL20.22182029
168TBK10.21538222

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.15349716
2Selenocompound metabolism_Homo sapiens_hsa004503.07557812
3Pentose phosphate pathway_Homo sapiens_hsa000303.02931999
4RNA transport_Homo sapiens_hsa030133.02726458
5Oxidative phosphorylation_Homo sapiens_hsa001902.97771305
6Vitamin B6 metabolism_Homo sapiens_hsa007502.86794533
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.84175253
8Parkinsons disease_Homo sapiens_hsa050122.77423149
9Protein export_Homo sapiens_hsa030602.70082240
10One carbon pool by folate_Homo sapiens_hsa006702.61637796
11Homologous recombination_Homo sapiens_hsa034402.54810472
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.50835569
13Ribosome_Homo sapiens_hsa030102.45142558
14Mismatch repair_Homo sapiens_hsa034302.34078993
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.24885513
16Fanconi anemia pathway_Homo sapiens_hsa034602.24712298
17Biosynthesis of amino acids_Homo sapiens_hsa012302.19689700
18mRNA surveillance pathway_Homo sapiens_hsa030152.13161482
19Cysteine and methionine metabolism_Homo sapiens_hsa002702.11220371
20Nitrogen metabolism_Homo sapiens_hsa009102.05205094
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04477062
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.96873636
23Fatty acid elongation_Homo sapiens_hsa000621.93047186
24Huntingtons disease_Homo sapiens_hsa050161.91787947
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.84438051
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.76093795
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75008887
28DNA replication_Homo sapiens_hsa030301.73379744
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.70840603
30Dorso-ventral axis formation_Homo sapiens_hsa043201.70599200
31Oocyte meiosis_Homo sapiens_hsa041141.69203610
32Basal transcription factors_Homo sapiens_hsa030221.69161253
33Cell cycle_Homo sapiens_hsa041101.67929766
34Carbon metabolism_Homo sapiens_hsa012001.67853333
35Pyruvate metabolism_Homo sapiens_hsa006201.61359813
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.61261239
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57891871
38Glucagon signaling pathway_Homo sapiens_hsa049221.54394316
39Alzheimers disease_Homo sapiens_hsa050101.52151867
40Spliceosome_Homo sapiens_hsa030401.40945188
41Systemic lupus erythematosus_Homo sapiens_hsa053221.38136191
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32810366
43Nucleotide excision repair_Homo sapiens_hsa034201.30095846
44Butanoate metabolism_Homo sapiens_hsa006501.27631398
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27008802
46mTOR signaling pathway_Homo sapiens_hsa041501.26562882
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25936771
48Arginine biosynthesis_Homo sapiens_hsa002201.18625786
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.17804608
50Peroxisome_Homo sapiens_hsa041461.17313436
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15884358
52Base excision repair_Homo sapiens_hsa034101.13081298
53Steroid biosynthesis_Homo sapiens_hsa001001.11167661
54Antigen processing and presentation_Homo sapiens_hsa046121.06154946
55RNA degradation_Homo sapiens_hsa030181.05650414
56Glycerolipid metabolism_Homo sapiens_hsa005611.05342001
57Glutathione metabolism_Homo sapiens_hsa004801.05059959
58Lysine degradation_Homo sapiens_hsa003101.04271631
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03501177
60p53 signaling pathway_Homo sapiens_hsa041151.01119236
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.97973390
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96875106
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.96191370
64Viral carcinogenesis_Homo sapiens_hsa052030.95917114
65Sulfur relay system_Homo sapiens_hsa041220.95745225
66Fatty acid biosynthesis_Homo sapiens_hsa000610.94149737
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92988162
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90732428
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90223488
70Non-homologous end-joining_Homo sapiens_hsa034500.90062013
71Metabolic pathways_Homo sapiens_hsa011000.89521478
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87510474
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87267794
74Propanoate metabolism_Homo sapiens_hsa006400.83727179
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.83339252
76Fructose and mannose metabolism_Homo sapiens_hsa000510.80545836
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79068444
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78814558
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76135517
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74230195
81AMPK signaling pathway_Homo sapiens_hsa041520.73706483
82Tryptophan metabolism_Homo sapiens_hsa003800.73160760
83Pyrimidine metabolism_Homo sapiens_hsa002400.70748358
84Regulation of autophagy_Homo sapiens_hsa041400.70690139
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68707524
86Phototransduction_Homo sapiens_hsa047440.66518123
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66470068
88Cardiac muscle contraction_Homo sapiens_hsa042600.66267834
89Folate biosynthesis_Homo sapiens_hsa007900.65069182
90Sulfur metabolism_Homo sapiens_hsa009200.63349725
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61874344
92Insulin signaling pathway_Homo sapiens_hsa049100.61280229
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.60474372
94Inositol phosphate metabolism_Homo sapiens_hsa005620.60031360
95Epstein-Barr virus infection_Homo sapiens_hsa051690.58496687
96Insulin resistance_Homo sapiens_hsa049310.57999554
97Fat digestion and absorption_Homo sapiens_hsa049750.55929130
98PPAR signaling pathway_Homo sapiens_hsa033200.54894562
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54856394
100ABC transporters_Homo sapiens_hsa020100.54610759
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53737279
102Chemical carcinogenesis_Homo sapiens_hsa052040.53009271
103HTLV-I infection_Homo sapiens_hsa051660.52383737
104Chronic myeloid leukemia_Homo sapiens_hsa052200.51956247
105Long-term potentiation_Homo sapiens_hsa047200.51768816
106Primary immunodeficiency_Homo sapiens_hsa053400.51588101
107Fatty acid degradation_Homo sapiens_hsa000710.51247246
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50628263
109Type II diabetes mellitus_Homo sapiens_hsa049300.50033393
110Estrogen signaling pathway_Homo sapiens_hsa049150.49972630
111Legionellosis_Homo sapiens_hsa051340.49357357
112Complement and coagulation cascades_Homo sapiens_hsa046100.49247663
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48705399
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48531549
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48167714
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48165201
117beta-Alanine metabolism_Homo sapiens_hsa004100.48033544
118Purine metabolism_Homo sapiens_hsa002300.47458257
119Retinol metabolism_Homo sapiens_hsa008300.45413168
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44806872
121Endometrial cancer_Homo sapiens_hsa052130.44110231
122Non-small cell lung cancer_Homo sapiens_hsa052230.43760139
123RNA polymerase_Homo sapiens_hsa030200.43351840
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43103829
125Arginine and proline metabolism_Homo sapiens_hsa003300.42373863
126T cell receptor signaling pathway_Homo sapiens_hsa046600.41511373
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41457620
128Herpes simplex infection_Homo sapiens_hsa051680.41176628
129Alcoholism_Homo sapiens_hsa050340.40710552
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40490941
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40244504
132MicroRNAs in cancer_Homo sapiens_hsa052060.38589175
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38161128
134Collecting duct acid secretion_Homo sapiens_hsa049660.37246859
135Maturity onset diabetes of the young_Homo sapiens_hsa049500.36200816
136Bile secretion_Homo sapiens_hsa049760.34980782
137Vibrio cholerae infection_Homo sapiens_hsa051100.34692389
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34606404
139Galactose metabolism_Homo sapiens_hsa000520.33176024
140Fatty acid metabolism_Homo sapiens_hsa012120.32529836
141Hippo signaling pathway_Homo sapiens_hsa043900.32487339
142N-Glycan biosynthesis_Homo sapiens_hsa005100.32327919
143Steroid hormone biosynthesis_Homo sapiens_hsa001400.31870751
144ErbB signaling pathway_Homo sapiens_hsa040120.31437474
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.31336273
146VEGF signaling pathway_Homo sapiens_hsa043700.30184958
147HIF-1 signaling pathway_Homo sapiens_hsa040660.29448983
148Adherens junction_Homo sapiens_hsa045200.29264225
149Colorectal cancer_Homo sapiens_hsa052100.29061550
150Vitamin digestion and absorption_Homo sapiens_hsa049770.28490329
151Linoleic acid metabolism_Homo sapiens_hsa005910.26195223

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