DDX11L8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)8.30937610
2protein neddylation (GO:0045116)7.25005524
3regulation of platelet aggregation (GO:0090330)6.90728773
4neutrophil activation involved in immune response (GO:0002283)6.13245162
5adenosine receptor signaling pathway (GO:0001973)5.90659167
6regulation of platelet activation (GO:0010543)5.63432166
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.25217097
8fusion of sperm to egg plasma membrane (GO:0007342)5.08010008
9purinergic nucleotide receptor signaling pathway (GO:0035590)4.81561385
10regulation of Golgi to plasma membrane protein transport (GO:0042996)4.81326180
11lipoxygenase pathway (GO:0019372)4.68355890
12positive regulation of mast cell activation (GO:0033005)4.59907588
13negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.53636399
14G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.52117287
15megakaryocyte development (GO:0035855)4.51873355
16blood coagulation, intrinsic pathway (GO:0007597)4.51616864
17leukocyte migration involved in inflammatory response (GO:0002523)4.43189611
18positive regulation of protein homodimerization activity (GO:0090073)4.29061061
19negative regulation of norepinephrine secretion (GO:0010700)4.22978651
20negative regulation of heart rate (GO:0010459)4.22003505
21regulation of integrin-mediated signaling pathway (GO:2001044)4.17849003
22poly(A)+ mRNA export from nucleus (GO:0016973)4.07798059
23purinergic receptor signaling pathway (GO:0035587)4.07485390
24platelet formation (GO:0030220)4.01354384
25negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.90772323
26platelet aggregation (GO:0070527)3.87052359
27negative regulation of thymocyte apoptotic process (GO:0070244)3.86523251
28regulation of homotypic cell-cell adhesion (GO:0034110)3.86334562
29positive regulation of interleukin-17 production (GO:0032740)3.80036143
30plasma membrane fusion (GO:0045026)3.78204582
31regulation of megakaryocyte differentiation (GO:0045652)3.73520877
32positive regulation of mast cell degranulation (GO:0043306)3.68212204
33positive regulation of mast cell activation involved in immune response (GO:0033008)3.68212204
34positive regulation of granulocyte differentiation (GO:0030854)3.65422075
35positive regulation of cAMP-mediated signaling (GO:0043950)3.63863282
36low-density lipoprotein particle remodeling (GO:0034374)3.63766991
37negative regulation of platelet activation (GO:0010544)3.62793068
38monoamine transport (GO:0015844)3.61387468
39angiogenesis involved in wound healing (GO:0060055)3.56072579
40regulation of memory T cell differentiation (GO:0043380)3.55184034
41negative regulation of neural precursor cell proliferation (GO:2000178)3.54213582
42ether lipid metabolic process (GO:0046485)3.53160383
43cardiolipin metabolic process (GO:0032048)3.52971396
44G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.52044832
45high-density lipoprotein particle remodeling (GO:0034375)3.49876154
46definitive hemopoiesis (GO:0060216)3.49123804
47negative regulation of response to food (GO:0032096)3.48226178
48negative regulation of appetite (GO:0032099)3.48226178
49negative regulation of protein localization to plasma membrane (GO:1903077)3.47686216
50positive regulation of endothelial cell differentiation (GO:0045603)3.47445240
51regulation of skeletal muscle contraction (GO:0014819)3.46081990
52regulation of mitochondrial depolarization (GO:0051900)3.43570222
53deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.39656206
54negative regulation of homotypic cell-cell adhesion (GO:0034111)3.35900441
55regulation of lipoprotein metabolic process (GO:0050746)3.28290624
56negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.25932604
57response to pheromone (GO:0019236)3.25416167
58neutrophil activation (GO:0042119)3.21558806
59germinal center formation (GO:0002467)3.20709614
60cyclooxygenase pathway (GO:0019371)3.19121324
61regulation of macrophage derived foam cell differentiation (GO:0010743)3.18811909
62reverse cholesterol transport (GO:0043691)3.17523377
63mature B cell differentiation involved in immune response (GO:0002313)3.16741111
64endothelium development (GO:0003158)3.15456392
65negative regulation of T cell apoptotic process (GO:0070233)3.15291588
66positive regulation of systemic arterial blood pressure (GO:0003084)3.14682648
67peptide catabolic process (GO:0043171)3.14550772
68vesicle targeting (GO:0006903)3.12876737
69regulation of mast cell degranulation (GO:0043304)3.08476143
70polyamine biosynthetic process (GO:0006596)3.06400102
71relaxation of smooth muscle (GO:0044557)3.06190487
72regulation of mast cell activation involved in immune response (GO:0033006)3.01246922
73negative regulation of protein localization to cell surface (GO:2000009)2.99229473
74positive regulation of Rho protein signal transduction (GO:0035025)2.98971436
75phosphatidylinositol acyl-chain remodeling (GO:0036149)2.96211374
76negative regulation of calcium ion transport into cytosol (GO:0010523)2.96161607
77platelet activation (GO:0030168)2.95731556
78pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.94287926
79regulation of integrin activation (GO:0033623)2.94093280
80regulation of mast cell activation (GO:0033003)2.92668849
81sleep (GO:0030431)2.90303848
82positive regulation of alpha-beta T cell proliferation (GO:0046641)2.89546884
83regulation of interleukin-17 production (GO:0032660)2.89225505
84regulation of cholesterol efflux (GO:0010874)2.85849008
85pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.84279483
86granulocyte activation (GO:0036230)2.82637356
87beta-amyloid metabolic process (GO:0050435)2.80866982
88positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.79870927
89pyrimidine nucleoside catabolic process (GO:0046135)2.79382470
90regulation of histone H3-K9 methylation (GO:0051570)2.77603003
91regulation of norepinephrine secretion (GO:0014061)2.71464505
92platelet degranulation (GO:0002576)2.71026040
93dopamine transport (GO:0015872)2.69352530
94fatty acid elongation (GO:0030497)2.68902234
95mitochondrial calcium ion transport (GO:0006851)2.68827771
96positive regulation of interleukin-4 production (GO:0032753)2.66121457
97positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.65377089
98negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.65039436
99long-chain fatty acid biosynthetic process (GO:0042759)2.64789322
100regulation of MHC class II biosynthetic process (GO:0045346)2.64438221

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human4.68387295
2SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.30017577
3LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.12983045
4GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.98364862
5RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.97718267
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.91407618
7GATA1_19941826_ChIP-Seq_K562_Human2.79916006
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.73833900
9IGF1R_20145208_ChIP-Seq_DFB_Human2.63000143
10LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.60248006
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.33330858
12GATA2_19941826_ChIP-Seq_K562_Human2.18809014
13HTT_18923047_ChIP-ChIP_STHdh_Human2.14550292
14GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.08151107
15TAF15_26573619_Chip-Seq_HEK293_Human2.07226794
16GATA1_19941827_ChIP-Seq_MEL_Mouse2.05020999
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91625542
18GATA1_22383799_ChIP-Seq_G1ME_Mouse1.91329449
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.89397875
20GBX2_23144817_ChIP-Seq_PC3_Human1.88600505
21GATA1_22025678_ChIP-Seq_K562_Human1.88222557
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86580800
23GATA2_21666600_ChIP-Seq_HMVEC_Human1.82060534
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81171838
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.78006722
26VDR_22108803_ChIP-Seq_LS180_Human1.77002387
27ELK4_26923725_Chip-Seq_MESODERM_Mouse1.70930740
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69512944
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66703268
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.66700158
31IRF1_19129219_ChIP-ChIP_H3396_Human1.60102688
32SPI1_23127762_ChIP-Seq_K562_Human1.58644290
33TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.58384192
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.57542586
35EWS_26573619_Chip-Seq_HEK293_Human1.57189510
36EZH2_22144423_ChIP-Seq_EOC_Human1.54400145
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.54271415
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52595707
39GATA1_19941827_ChIP-Seq_MEL86_Mouse1.47284983
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45909983
41ER_23166858_ChIP-Seq_MCF-7_Human1.43508539
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43198471
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.42073468
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.40820014
45VDR_24763502_ChIP-Seq_THP-1_Human1.40585370
46GATA2_22383799_ChIP-Seq_G1ME_Mouse1.40107802
47UTX_26944678_Chip-Seq_JUKART_Human1.37589485
48GATA3_21878914_ChIP-Seq_MCF-7_Human1.37488170
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31019174
50ETS1_22383799_ChIP-Seq_G1ME_Mouse1.29870889
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28174206
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24950459
53GATA3_27048872_Chip-Seq_THYMUS_Human1.20956674
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.20786732
55YY1_22570637_ChIP-Seq_MALME-3M_Human1.19859917
56NANOG_20526341_ChIP-Seq_ESCs_Human1.18187807
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.16671092
58FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15611009
59PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14301665
60SALL4_22934838_ChIP-ChIP_CD34+_Human1.13826724
61ZNF274_21170338_ChIP-Seq_K562_Hela1.11210812
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10201567
63TP53_22573176_ChIP-Seq_HFKS_Human1.09723313
64ERG_20517297_ChIP-Seq_VCAP_Human1.09549099
65EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.09414166
66SPI1_20517297_ChIP-Seq_HL60_Human1.09395221
67IRF8_22096565_ChIP-ChIP_GC-B_Human1.09247587
68SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08047534
69BCAT_22108803_ChIP-Seq_LS180_Human1.06830168
70RUNX_20019798_ChIP-Seq_JUKART_Human1.06237520
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04954182
72STAT1_20625510_ChIP-Seq_HELA_Human1.04858245
73GATA3_26560356_Chip-Seq_TH2_Human1.04441861
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03353844
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03353844
76CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01266314
77MAF_26560356_Chip-Seq_TH1_Human1.00715951
78FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00001798
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99148685
80BCL6_27268052_Chip-Seq_Bcells_Human0.98881465
81FOXA1_25329375_ChIP-Seq_VCAP_Human0.96059133
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96059133
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95935809
84IRF8_27001747_Chip-Seq_BMDM_Mouse0.94541028
85NCOR1_26117541_ChIP-Seq_K562_Human0.93741007
86BCOR_27268052_Chip-Seq_Bcells_Human0.92361531
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91865309
88PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90985741
89MYB_26560356_Chip-Seq_TH2_Human0.89625107
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89009355
91VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88902568
92TAF2_19829295_ChIP-Seq_ESCs_Human0.88563049
93NANOG_19829295_ChIP-Seq_ESCs_Human0.88255076
94SOX2_19829295_ChIP-Seq_ESCs_Human0.88255076
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88039587
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88020393
97VDR_24787735_ChIP-Seq_THP-1_Human0.87233608
98OCT1_27270436_Chip-Seq_PROSTATE_Human0.85740613
99ESR1_20079471_ChIP-ChIP_T-47D_Human0.85733500
100CEBPB_22108803_ChIP-Seq_LS180_Human0.85601301

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology8.78464520
2MP0005084_abnormal_gallbladder_morpholo3.92217778
3MP0008004_abnormal_stomach_pH3.69654594
4MP0000465_gastrointestinal_hemorrhage3.58315377
5MP0003303_peritoneal_inflammation3.50039034
6MP0003724_increased_susceptibility_to2.99314299
7MP0002102_abnormal_ear_morphology2.64576341
8MP0005167_abnormal_blood-brain_barrier2.18573596
9MP0000015_abnormal_ear_pigmentation2.15068081
10MP0005083_abnormal_biliary_tract2.12429496
11MP0005410_abnormal_fertilization2.07441600
12MP0005174_abnormal_tail_pigmentation2.01060634
13MP0002653_abnormal_ependyma_morphology2.01024809
14MP0005397_hematopoietic_system_phenotyp1.95866268
15MP0001545_abnormal_hematopoietic_system1.95866268
16MP0001835_abnormal_antigen_presentation1.94972262
17MP0004130_abnormal_muscle_cell1.93996491
18MP0001661_extended_life_span1.92522877
19MP0002736_abnormal_nociception_after1.89964434
20MP0009697_abnormal_copulation1.86025622
21MP0000230_abnormal_systemic_arterial1.83894841
22MP0001968_abnormal_touch/_nociception1.78317247
23MP0000343_altered_response_to1.64334255
24MP0001664_abnormal_digestion1.62304252
25MP0005646_abnormal_pituitary_gland1.60736672
26MP0010368_abnormal_lymphatic_system1.59849478
27MP0001188_hyperpigmentation1.57991800
28MP0003136_yellow_coat_color1.57129585
29MP0005377_hearing/vestibular/ear_phenot1.48938245
30MP0003878_abnormal_ear_physiology1.48938245
31MP0001663_abnormal_digestive_system1.45243855
32MP0008872_abnormal_physiological_respon1.45215254
33MP0004134_abnormal_chest_morphology1.44224126
34MP0002148_abnormal_hypersensitivity_rea1.38513452
35MP0004808_abnormal_hematopoietic_stem1.34341931
36MP0005075_abnormal_melanosome_morpholog1.32177324
37MP0005171_absent_coat_pigmentation1.28289293
38MP0002398_abnormal_bone_marrow1.26968910
39MP0001879_abnormal_lymphatic_vessel1.25370604
40MP0005409_darkened_coat_color1.24795803
41MP0003638_abnormal_response/metabolism_1.23881170
42MP0004084_abnormal_cardiac_muscle1.19389986
43MP0001851_eye_inflammation1.14249970
44MP0009278_abnormal_bone_marrow1.12980685
45MP0000383_abnormal_hair_follicle1.11883373
46MP0010155_abnormal_intestine_physiology1.11265140
47MP0003656_abnormal_erythrocyte_physiolo1.09979055
48MP0003828_pulmonary_edema1.08864291
49MP0004147_increased_porphyrin_level1.08859667
50MP0002733_abnormal_thermal_nociception1.06654391
51MP0004381_abnormal_hair_follicle1.04019591
52MP0002132_abnormal_respiratory_system1.03383377
53MP0006276_abnormal_autonomic_nervous1.02225338
54MP0005535_abnormal_body_temperature1.01978654
55MP0001765_abnormal_ion_homeostasis1.01780693
56MP0010329_abnormal_lipoprotein_level0.97488286
57MP0002735_abnormal_chemical_nociception0.97047992
58MP0000249_abnormal_blood_vessel0.96834055
59MP0008775_abnormal_heart_ventricle0.95030305
60MP0000689_abnormal_spleen_morphology0.94633947
61MP0005666_abnormal_adipose_tissue0.93528556
62MP0005000_abnormal_immune_tolerance0.90375599
63MP0005381_digestive/alimentary_phenotyp0.89078281
64MP0006292_abnormal_olfactory_placode0.88953594
65MP0005501_abnormal_skin_physiology0.87729389
66MP0002429_abnormal_blood_cell0.87191179
67MP0005671_abnormal_response_to0.85964085
68MP0003763_abnormal_thymus_physiology0.85832815
69MP0002876_abnormal_thyroid_physiology0.85736904
70MP0009333_abnormal_splenocyte_physiolog0.84607800
71MP0004185_abnormal_adipocyte_glucose0.84398800
72MP0004510_myositis0.84151018
73MP0008875_abnormal_xenobiotic_pharmacok0.83661197
74MP0002160_abnormal_reproductive_system0.83120864
75MP0008874_decreased_physiological_sensi0.79180148
76MP0005551_abnormal_eye_electrophysiolog0.78879327
77MP0010386_abnormal_urinary_bladder0.78247700
78MP0009642_abnormal_blood_homeostasis0.77285288
79MP0001986_abnormal_taste_sensitivity0.77186137
80MP0001756_abnormal_urination0.76078544
81MP0002722_abnormal_immune_system0.75018609
82MP0000490_abnormal_crypts_of0.74552215
83MP0004215_abnormal_myocardial_fiber0.74390737
84MP0002723_abnormal_immune_serum0.74349883
85MP0008569_lethality_at_weaning0.74128350
86MP0006036_abnormal_mitochondrial_physio0.73867803
87MP0003879_abnormal_hair_cell0.72566710
88MP0003011_delayed_dark_adaptation0.72078191
89MP0003183_abnormal_peptide_metabolism0.70464697
90MP0003566_abnormal_cell_adhesion0.68961744
91MP0000716_abnormal_immune_system0.68726678
92MP0003718_maternal_effect0.67998822
93MP0001970_abnormal_pain_threshold0.67447920
94MP0000372_irregular_coat_pigmentation0.65220919
95MP0003698_abnormal_male_reproductive0.62820624
96MP0001800_abnormal_humoral_immune0.62408190
97MP0000681_abnormal_thyroid_gland0.62023228
98MP0002452_abnormal_antigen_presenting0.61595980
99MP0002118_abnormal_lipid_homeostasis0.60676320
100MP0002420_abnormal_adaptive_immunity0.60350581

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)8.21860534
2Menorrhagia (HP:0000132)8.14940519
3Increased mean platelet volume (HP:0011877)8.09297765
4Abnormal platelet volume (HP:0011876)7.67020981
5Purpura (HP:0000979)7.13271671
6Epistaxis (HP:0000421)6.77759830
7Hyperlipoproteinemia (HP:0010980)5.39110505
8Gingival bleeding (HP:0000225)5.19267775
9Abnormal platelet function (HP:0011869)5.03678772
10Impaired platelet aggregation (HP:0003540)5.03678772
11Dyschromatopsia (HP:0007641)4.93404766
12Renal Fanconi syndrome (HP:0001994)4.45300999
13Decreased central vision (HP:0007663)4.27829045
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.93907830
15Attenuation of retinal blood vessels (HP:0007843)3.77153141
16Poikilocytosis (HP:0004447)3.67316236
17Exertional dyspnea (HP:0002875)3.60268878
18Acanthocytosis (HP:0001927)3.59048659
19Papillary thyroid carcinoma (HP:0002895)3.56169015
20Increased hepatocellular lipid droplets (HP:0006565)3.50673739
21Lipid accumulation in hepatocytes (HP:0006561)3.14203728
22Abnormal pupillary function (HP:0007686)3.12675918
23Spontaneous hematomas (HP:0007420)3.06211132
24Abnormality of lateral ventricle (HP:0030047)2.90681267
25Bruising susceptibility (HP:0000978)2.88229517
26Joint hemorrhage (HP:0005261)2.85378382
27Abnormality of renal resorption (HP:0011038)2.83263000
28Abnormality of the common coagulation pathway (HP:0010990)2.79789967
29Conjunctival telangiectasia (HP:0000524)2.76734401
30Abnormal rod and cone electroretinograms (HP:0008323)2.62676229
31Paralysis (HP:0003470)2.61244844
32Abnormality of the heme biosynthetic pathway (HP:0010472)2.60745124
33Increased intramyocellular lipid droplets (HP:0012240)2.55266348
34Abnormal auditory evoked potentials (HP:0006958)2.48948714
35Back pain (HP:0003418)2.39448744
36Abnormality of the vasculature of the conjunctiva (HP:0008054)2.38779029
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.33567251
38Thyroid-stimulating hormone excess (HP:0002925)2.29037907
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.24759665
40Thyroid carcinoma (HP:0002890)2.22433951
41Increased muscle lipid content (HP:0009058)2.21820005
42Respiratory difficulties (HP:0002880)2.16370575
43Dynein arm defect of respiratory motile cilia (HP:0012255)2.15230847
44Absent/shortened dynein arms (HP:0200106)2.15230847
45Hypophosphatemic rickets (HP:0004912)2.14130163
46Atonic seizures (HP:0010819)2.03921489
47Abnormal ciliary motility (HP:0012262)2.01700976
48Long clavicles (HP:0000890)2.00887300
49Prolonged bleeding time (HP:0003010)10.2056785
50Joint swelling (HP:0001386)1.95383373
51Metaphyseal dysplasia (HP:0100255)1.94329849
52Spontaneous abortion (HP:0005268)1.91542760
53Generalized aminoaciduria (HP:0002909)1.91099146
54Choroideremia (HP:0001139)1.90131981
55Hypomagnesemia (HP:0002917)1.86084080
56Male infertility (HP:0003251)1.84027453
57Febrile seizures (HP:0002373)1.83611948
58Facial diplegia (HP:0001349)1.82668280
59Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80695750
60Acute lymphatic leukemia (HP:0006721)1.80364247
61Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.79638164
62Abnormal respiratory motile cilium morphology (HP:0005938)1.78146718
63Abnormal respiratory epithelium morphology (HP:0012253)1.78146718
64Renal cortical cysts (HP:0000803)1.77779502
65Chronic otitis media (HP:0000389)1.76701036
66Glycosuria (HP:0003076)1.75088470
67Abnormality of urine glucose concentration (HP:0011016)1.75088470
68Muscle fiber atrophy (HP:0100295)1.74945286
69Hepatosplenomegaly (HP:0001433)1.73801003
70Increased density of long bones (HP:0006392)1.71608922
71Abnormality of iron homeostasis (HP:0011031)1.68964044
72Abnormality of the hepatic vasculature (HP:0006707)1.68094548
73Facial hemangioma (HP:0000329)1.67856171
74Type 2 muscle fiber atrophy (HP:0003554)1.66843324
75Renal tubular dysfunction (HP:0000124)1.65208832
76Thrombocytosis (HP:0001894)1.64333322
77Congenital stationary night blindness (HP:0007642)1.61444120
78Constricted visual fields (HP:0001133)1.60836309
79Abolished electroretinogram (ERG) (HP:0000550)1.59700316
80Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.57482105
81Rectovaginal fistula (HP:0000143)1.56603599
82Rectal fistula (HP:0100590)1.56603599
83Abnormality of transition element cation homeostasis (HP:0011030)1.55566407
84Hyperphosphaturia (HP:0003109)1.55197268
85Pendular nystagmus (HP:0012043)1.52930359
86Abnormality of the costochondral junction (HP:0000919)1.52274719
87Xanthomatosis (HP:0000991)1.52145707
88Autoimmune hemolytic anemia (HP:0001890)1.50913476
89Arterial thrombosis (HP:0004420)1.50726395
90Stomatitis (HP:0010280)1.50462361
91Genetic anticipation (HP:0003743)1.50224440
92Abnormal urine phosphate concentration (HP:0012599)1.47887694
93Abnormality of alanine metabolism (HP:0010916)1.47674128
94Hyperalaninemia (HP:0003348)1.47674128
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.47674128
96Portal hypertension (HP:0001409)1.47322612
97Increased IgM level (HP:0003496)1.46110187
98Abnormality of magnesium homeostasis (HP:0004921)1.44907881
99Failure to thrive in infancy (HP:0001531)1.44491159
100Hypertriglyceridemia (HP:0002155)1.42387049

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.14466822
2MST43.84105515
3RIPK43.35925172
4BMX3.25605277
5NUAK12.94252296
6ACVR1B2.32509917
7BMPR22.24832218
8SYK2.13998617
9BTK2.13720248
10TAOK32.13483599
11TEC2.13439082
12MYLK2.08049532
13MAP2K32.06367805
14STK32.05697517
15PTK2B1.96330902
16CSF1R1.96070401
17ADRBK21.95558695
18GRK51.86921161
19ZAP701.85011105
20MATK1.74819386
21BRD41.70384481
22EIF2AK31.68348493
23GRK61.52918979
24TNIK1.49593652
25TXK1.49119464
26HCK1.38515404
27PIK3CG1.32971512
28TNK21.28641365
29MAPK151.28475151
30EIF2AK21.21742428
31BCKDK1.16368278
32IKBKB1.15362192
33EIF2AK11.13771110
34ADRBK11.09474693
35ILK1.07715443
36ZAK1.06415822
37WNK41.06218152
38LYN1.01071825
39MKNK11.00225599
40PRKCQ0.99482327
41PNCK0.99042501
42TAF10.97784315
43DAPK30.97011096
44MARK30.92377017
45FES0.92287302
46DAPK20.91744103
47PLK20.91057071
48FLT30.81843106
49BLK0.79944067
50TLK10.78421231
51ERBB30.77794599
52PIM20.77570787
53MAPK120.75742536
54MAP4K10.75665067
55PAK10.73471386
56TESK20.73265988
57VRK10.72789799
58CCNB10.70452901
59PRKD10.69106292
60SMG10.66939646
61BMPR1B0.66549159
62TGFBR10.65472484
63MAP2K10.63467642
64PINK10.61575340
65VRK20.56689344
66IRAK10.53981654
67LCK0.53927573
68PKN10.52527672
69HIPK20.52348597
70KIT0.52346705
71LMTK20.52148718
72PDPK10.51485501
73MAPKAPK30.50543498
74PDK10.50408259
75PRKG10.48150671
76PHKG20.47143974
77PHKG10.47143974
78ARAF0.46656692
79ITK0.45231842
80FER0.45070132
81FGR0.44493239
82MUSK0.42999207
83MAPK130.42364727
84STK390.42198757
85DYRK30.42142632
86PRKCD0.40618490
87TAOK20.40318548
88MAP3K50.39581377
89MAP3K140.38392777
90GRK10.37910155
91TRIM280.37574602
92EPHB20.36905073
93STK40.36901323
94RET0.35617893
95CDK90.35175590
96BRSK20.33723974
97CAMKK20.33360834
98EPHA30.32542312
99RPS6KA50.32277888
100MINK10.32184546

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046114.95323988
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.02076213
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.97470517
4SNARE interactions in vesicular transport_Homo sapiens_hsa041302.85908984
5Arachidonic acid metabolism_Homo sapiens_hsa005902.75678392
6Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.67234665
7Linoleic acid metabolism_Homo sapiens_hsa005912.54234766
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.26579168
9Serotonergic synapse_Homo sapiens_hsa047262.13167938
10Hematopoietic cell lineage_Homo sapiens_hsa046402.02353267
11Vascular smooth muscle contraction_Homo sapiens_hsa042701.93663706
12Nitrogen metabolism_Homo sapiens_hsa009101.91905816
13Gap junction_Homo sapiens_hsa045401.83040598
14Sulfur metabolism_Homo sapiens_hsa009201.75690800
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.68090110
16Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.64107843
17Sulfur relay system_Homo sapiens_hsa041221.60833124
18Long-term depression_Homo sapiens_hsa047301.59962225
19Alcoholism_Homo sapiens_hsa050341.59254056
20Phototransduction_Homo sapiens_hsa047441.46183807
21Systemic lupus erythematosus_Homo sapiens_hsa053221.45767652
22Glutathione metabolism_Homo sapiens_hsa004801.45630951
23ECM-receptor interaction_Homo sapiens_hsa045121.39967368
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.35954750
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.31095066
26Pancreatic secretion_Homo sapiens_hsa049721.27508130
27Glycerolipid metabolism_Homo sapiens_hsa005611.24284590
28Olfactory transduction_Homo sapiens_hsa047401.23483869
29Circadian entrainment_Homo sapiens_hsa047131.23190098
30Fatty acid elongation_Homo sapiens_hsa000621.18156044
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.18135677
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13797697
33Chemokine signaling pathway_Homo sapiens_hsa040621.12289798
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11504877
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11282365
36Taste transduction_Homo sapiens_hsa047421.08369305
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06979242
38Salivary secretion_Homo sapiens_hsa049701.00979167
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95479203
40Fat digestion and absorption_Homo sapiens_hsa049750.91955206
41Calcium signaling pathway_Homo sapiens_hsa040200.90954159
42Ether lipid metabolism_Homo sapiens_hsa005650.90164587
43Chemical carcinogenesis_Homo sapiens_hsa052040.89163225
44Collecting duct acid secretion_Homo sapiens_hsa049660.87807099
45Endocytosis_Homo sapiens_hsa041440.86591013
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.84713447
47Renin secretion_Homo sapiens_hsa049240.83613155
48Morphine addiction_Homo sapiens_hsa050320.80856877
49B cell receptor signaling pathway_Homo sapiens_hsa046620.74237392
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.71806362
51Sphingolipid metabolism_Homo sapiens_hsa006000.70940150
52Primary immunodeficiency_Homo sapiens_hsa053400.69502258
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68626205
54Ovarian steroidogenesis_Homo sapiens_hsa049130.68186065
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67701204
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67505666
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65668571
58African trypanosomiasis_Homo sapiens_hsa051430.62559432
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62058827
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61212927
61Retinol metabolism_Homo sapiens_hsa008300.59714396
62ABC transporters_Homo sapiens_hsa020100.58735993
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58017727
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57777769
65Renin-angiotensin system_Homo sapiens_hsa046140.56388197
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55971998
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.55479459
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54364226
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51961949
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51538574
71Cholinergic synapse_Homo sapiens_hsa047250.50583585
72Glutamatergic synapse_Homo sapiens_hsa047240.50568490
73Viral carcinogenesis_Homo sapiens_hsa052030.49497206
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48852940
75T cell receptor signaling pathway_Homo sapiens_hsa046600.48211560
76Shigellosis_Homo sapiens_hsa051310.47588167
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47502454
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46391488
79beta-Alanine metabolism_Homo sapiens_hsa004100.46091149
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45033395
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.43795847
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41660612
83Choline metabolism in cancer_Homo sapiens_hsa052310.41233167
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40240588
85Malaria_Homo sapiens_hsa051440.39808448
86Peroxisome_Homo sapiens_hsa041460.39239532
87Gastric acid secretion_Homo sapiens_hsa049710.37928009
88GABAergic synapse_Homo sapiens_hsa047270.37629405
89Melanoma_Homo sapiens_hsa052180.37055978
90Starch and sucrose metabolism_Homo sapiens_hsa005000.36094750
91Purine metabolism_Homo sapiens_hsa002300.36072173
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35570807
93Dopaminergic synapse_Homo sapiens_hsa047280.34902958
94Oxytocin signaling pathway_Homo sapiens_hsa049210.34680571
95Rap1 signaling pathway_Homo sapiens_hsa040150.30324814
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.29171436
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28575361
98Inositol phosphate metabolism_Homo sapiens_hsa005620.27847091
99Ras signaling pathway_Homo sapiens_hsa040140.25257963
100Lysosome_Homo sapiens_hsa041420.24313839

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »