DDX11L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)7.93535550
2thrombin receptor signaling pathway (GO:0070493)7.53804124
3protein neddylation (GO:0045116)7.41936824
4regulation of platelet aggregation (GO:0090330)6.09823704
5adenosine receptor signaling pathway (GO:0001973)5.96685963
6regulation of platelet activation (GO:0010543)5.62699925
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.52778115
8leukocyte migration involved in inflammatory response (GO:0002523)5.34996577
9platelet aggregation (GO:0070527)5.32097865
10blood coagulation, intrinsic pathway (GO:0007597)5.19202458
11G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.87254524
12negative regulation of thymocyte apoptotic process (GO:0070244)4.81953228
13lipoxygenase pathway (GO:0019372)4.81016890
14regulation of integrin-mediated signaling pathway (GO:2001044)4.71877289
15neutrophil activation (GO:0042119)4.68699504
16negative regulation of homotypic cell-cell adhesion (GO:0034111)4.59733735
17megakaryocyte development (GO:0035855)4.56665157
18negative regulation of norepinephrine secretion (GO:0010700)4.52597453
19purinergic nucleotide receptor signaling pathway (GO:0035590)4.47526871
20negative regulation of platelet activation (GO:0010544)4.46245867
21positive regulation of mast cell activation (GO:0033005)4.44088855
22negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.30539596
23granulocyte activation (GO:0036230)4.24046604
24low-density lipoprotein particle remodeling (GO:0034374)4.18674100
25angiogenesis involved in wound healing (GO:0060055)4.03791391
26positive regulation of endothelial cell differentiation (GO:0045603)4.02211472
27platelet formation (GO:0030220)4.00188640
28regulation of Golgi to plasma membrane protein transport (GO:0042996)4.00104036
29positive regulation of systemic arterial blood pressure (GO:0003084)3.93754399
30platelet degranulation (GO:0002576)3.93467748
31regulation of integrin activation (GO:0033623)3.92932476
32purinergic receptor signaling pathway (GO:0035587)3.85226848
33negative regulation of heart rate (GO:0010459)3.82156569
34G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.78906620
35positive regulation of Rho protein signal transduction (GO:0035025)3.76313742
36homotypic cell-cell adhesion (GO:0034109)3.71673601
37positive regulation of macrophage differentiation (GO:0045651)3.70039009
38platelet activation (GO:0030168)3.69191442
39leukocyte degranulation (GO:0043299)3.66401822
40fusion of sperm to egg plasma membrane (GO:0007342)3.62910650
41regulation of homotypic cell-cell adhesion (GO:0034110)3.53691193
42regulation of mast cell degranulation (GO:0043304)3.53526242
43positive regulation of cAMP-mediated signaling (GO:0043950)3.49932268
44negative regulation of appetite (GO:0032099)3.49393137
45negative regulation of response to food (GO:0032096)3.49393137
46positive regulation of receptor recycling (GO:0001921)3.49055383
47polyamine biosynthetic process (GO:0006596)3.43833151
48Arp2/3 complex-mediated actin nucleation (GO:0034314)3.42168334
49positive regulation of granulocyte differentiation (GO:0030854)3.38166232
50beta-amyloid metabolic process (GO:0050435)3.38097211
51regulation of lipoprotein metabolic process (GO:0050746)3.37033122
52regulation of mast cell activation involved in immune response (GO:0033006)3.34978643
53regulation of MHC class II biosynthetic process (GO:0045346)3.33177286
54negative regulation of T cell apoptotic process (GO:0070233)3.29933055
55high-density lipoprotein particle remodeling (GO:0034375)3.29776919
56regulation of mast cell activation (GO:0033003)3.27472354
57negative regulation of protein localization to cell surface (GO:2000009)3.27398715
58regulation of cholesterol efflux (GO:0010874)3.26405915
59autophagic vacuole fusion (GO:0000046)3.26247587
60regulation of macrophage derived foam cell differentiation (GO:0010743)3.25707940
61negative regulation of neural precursor cell proliferation (GO:2000178)3.24641862
62positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.22233691
63negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.21281991
64positive regulation of hemostasis (GO:1900048)3.19509219
65positive regulation of blood coagulation (GO:0030194)3.19509219
66regulation of female receptivity (GO:0045924)3.19337127
67mitochondrial calcium ion transport (GO:0006851)3.18641205
68extracellular fibril organization (GO:0043206)3.15328931
69vesicle targeting (GO:0006903)3.12512224
70negative regulation of protein localization to plasma membrane (GO:1903077)3.11838459
71cyclooxygenase pathway (GO:0019371)3.09588870
72regulation of norepinephrine secretion (GO:0014061)3.08932058
73positive regulation of mast cell degranulation (GO:0043306)3.07842670
74positive regulation of mast cell activation involved in immune response (GO:0033008)3.07842670
75reverse cholesterol transport (GO:0043691)3.05160672
76negative regulation of T-helper cell differentiation (GO:0045623)3.03789621
77negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.03789621
78negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.97372908
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.94808992
80termination of G-protein coupled receptor signaling pathway (GO:0038032)2.94303053
81termination of signal transduction (GO:0023021)2.93678602
82female mating behavior (GO:0060180)2.92677322
83negative regulation of stress fiber assembly (GO:0051497)2.92311352
84poly(A)+ mRNA export from nucleus (GO:0016973)2.91933956
85negative regulation of heart contraction (GO:0045822)2.88989863
86endothelium development (GO:0003158)2.88536253
87peptide catabolic process (GO:0043171)2.88234611
88negative regulation of erythrocyte differentiation (GO:0045647)2.87935074
89regulation of T-helper 1 cell differentiation (GO:0045625)2.86675305
90myeloid cell activation involved in immune response (GO:0002275)2.85873039
91regulation of receptor recycling (GO:0001919)2.85287317
92phagocytosis, engulfment (GO:0006911)2.85277066
93pyrimidine nucleoside catabolic process (GO:0046135)2.84119287
94regulation of regulatory T cell differentiation (GO:0045589)2.82941982
95positive regulation of coagulation (GO:0050820)2.82549096
96phospholipid homeostasis (GO:0055091)2.78116979
97regulation of memory T cell differentiation (GO:0043380)2.77616336
98myeloid cell development (GO:0061515)2.77390718
99cardiolipin metabolic process (GO:0032048)2.77354983
100regulation of megakaryocyte differentiation (GO:0045652)2.77081534

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.71319523
2SCL_19346495_ChIP-Seq_HPC-7_Human4.69187511
3LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.34875650
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.96059288
5RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.77085952
6GATA1_19941826_ChIP-Seq_K562_Human3.55427304
7GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.16050808
8LMO2_20887958_ChIP-Seq_HPC-7_Mouse3.08112561
9GATA2_19941826_ChIP-Seq_K562_Human2.84576853
10GATA1_19941827_ChIP-Seq_MEL_Mouse2.84103629
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.80090693
12SPI1_23127762_ChIP-Seq_K562_Human2.76099217
13GATA1_22383799_ChIP-Seq_G1ME_Mouse2.68095231
14TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.63844953
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.59128152
16SRY_22984422_ChIP-ChIP_TESTIS_Rat2.58024912
17GATA1_22025678_ChIP-Seq_K562_Human2.57489350
18RUNX1_22412390_ChIP-Seq_EML_Mouse2.49169294
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.42899366
20MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.42036473
21GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.41959598
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.37195525
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.30672681
24GATA2_21666600_ChIP-Seq_HMVEC_Human2.25795529
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16720441
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03937972
27STAT6_21828071_ChIP-Seq_BEAS2B_Human2.02850750
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.96787865
29IRF8_27001747_Chip-Seq_BMDM_Mouse1.91114462
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.87935955
31ELK4_26923725_Chip-Seq_MESODERM_Mouse1.87095389
32UTX_26944678_Chip-Seq_JUKART_Human1.79835983
33NCOR1_26117541_ChIP-Seq_K562_Human1.78573756
34GATA2_22383799_ChIP-Seq_G1ME_Mouse1.77337111
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71948498
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70578395
37VDR_24763502_ChIP-Seq_THP-1_Human1.65161364
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65159297
39SPI1_23547873_ChIP-Seq_NB4_Human1.63760055
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62242234
41GATA1_19941827_ChIP-Seq_MEL86_Mouse1.60478489
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55618784
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54344916
44HTT_18923047_ChIP-ChIP_STHdh_Human1.53358738
45MAF_26560356_Chip-Seq_TH1_Human1.48289871
46RUNX_20019798_ChIP-Seq_JUKART_Human1.46719062
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.43681508
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.41472488
49SPI1_20517297_ChIP-Seq_HL60_Human1.39788007
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.34570350
51ETS1_22383799_ChIP-Seq_G1ME_Mouse1.30812539
52PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.30432441
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28884213
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28803454
55MYC_22102868_ChIP-Seq_BL_Human1.28221011
56TCF7_22412390_ChIP-Seq_EML_Mouse1.27858693
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26750448
58MYB_26560356_Chip-Seq_TH2_Human1.26562300
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25955609
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16832633
61PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15504065
62HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13826808
63GATA3_27048872_Chip-Seq_THYMUS_Human1.11796717
64MYB_26560356_Chip-Seq_TH1_Human1.11001055
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09698909
66KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.09105870
67CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08556453
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.08377785
69STAT1_20625510_ChIP-Seq_HELA_Human1.07861567
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07337103
71CTCF_21964334_ChIP-Seq_BJAB-B_Human1.07221955
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06605450
73CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06296672
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05999914
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04840891
76FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04095923
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03137714
78BCL6_27268052_Chip-Seq_Bcells_Human1.01626598
79BCOR_27268052_Chip-Seq_Bcells_Human1.01474197
80VDR_21846776_ChIP-Seq_THP-1_Human1.01195422
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99303532
82RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97739004
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97603315
84CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96630101
85CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96479199
86SALL4_22934838_ChIP-ChIP_CD34+_Human0.93036047
87ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90844591
88ELF1_20517297_ChIP-Seq_JURKAT_Human0.89457820
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89291995
90CTCF_21964334_Chip-Seq_Bcells_Human0.89253673
91GATA3_26560356_Chip-Seq_TH2_Human0.89242733
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.88703862
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87227737
94YY1_22570637_ChIP-Seq_MALME-3M_Human0.86565394
95PU_27001747_Chip-Seq_BMDM_Mouse0.85502397
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84038826
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81109552
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80435963
99* MAF_26560356_Chip-Seq_TH2_Human0.78351154
100KDM2B_26808549_Chip-Seq_SUP-B15_Human0.78164378

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology9.46428241
2MP0008004_abnormal_stomach_pH5.03725787
3MP0003724_increased_susceptibility_to3.55824036
4MP0000465_gastrointestinal_hemorrhage3.29165695
5MP0003303_peritoneal_inflammation3.18737350
6MP0001835_abnormal_antigen_presentation2.59791932
7MP0005083_abnormal_biliary_tract2.43835077
8MP0004510_myositis2.27853284
9MP0000343_altered_response_to2.17327630
10MP0005058_abnormal_lysosome_morphology2.13903483
11MP0005084_abnormal_gallbladder_morpholo2.11461750
12MP0005397_hematopoietic_system_phenotyp2.09362333
13MP0001545_abnormal_hematopoietic_system2.09362333
14MP0003436_decreased_susceptibility_to1.88522447
15MP0003566_abnormal_cell_adhesion1.86374968
16MP0010155_abnormal_intestine_physiology1.83820830
17MP0002148_abnormal_hypersensitivity_rea1.78987813
18MP0002398_abnormal_bone_marrow1.78881273
19MP0000230_abnormal_systemic_arterial1.77039282
20MP0005000_abnormal_immune_tolerance1.73618403
21MP0003828_pulmonary_edema1.71516999
22MP0005671_abnormal_response_to1.71275579
23MP0002736_abnormal_nociception_after1.65775580
24MP0002132_abnormal_respiratory_system1.65003560
25MP0005410_abnormal_fertilization1.59993679
26MP0001851_eye_inflammation1.57485781
27MP0009278_abnormal_bone_marrow1.53815502
28MP0004947_skin_inflammation1.48583201
29MP0003638_abnormal_response/metabolism_1.48196995
30MP0001879_abnormal_lymphatic_vessel1.45770544
31MP0002723_abnormal_immune_serum1.41640431
32MP0001663_abnormal_digestive_system1.41155010
33MP0004130_abnormal_muscle_cell1.39992466
34MP0000015_abnormal_ear_pigmentation1.36481876
35MP0004084_abnormal_cardiac_muscle1.33226848
36MP0003656_abnormal_erythrocyte_physiolo1.33183845
37MP0001800_abnormal_humoral_immune1.32508950
38MP0009333_abnormal_splenocyte_physiolog1.31396526
39MP0000689_abnormal_spleen_morphology1.31272545
40MP0005167_abnormal_blood-brain_barrier1.31072927
41MP0002452_abnormal_antigen_presenting1.30009278
42MP0008872_abnormal_physiological_respon1.29646619
43MP0002429_abnormal_blood_cell1.29312584
44MP0000858_altered_metastatic_potential1.26308123
45MP0005174_abnormal_tail_pigmentation1.25840754
46MP0002420_abnormal_adaptive_immunity1.23704443
47MP0002722_abnormal_immune_system1.23441008
48MP0001968_abnormal_touch/_nociception1.23167718
49MP0001533_abnormal_skeleton_physiology1.22527963
50MP0001819_abnormal_immune_cell1.21697064
51MP0002419_abnormal_innate_immunity1.20550182
52MP0000249_abnormal_blood_vessel1.17750152
53MP0008775_abnormal_heart_ventricle1.16687932
54MP0005409_darkened_coat_color1.16560247
55MP0000716_abnormal_immune_system1.13770810
56MP0005025_abnormal_response_to1.10985078
57MP0003879_abnormal_hair_cell1.10669379
58MP0009763_increased_sensitivity_to1.09593851
59MP0004036_abnormal_muscle_relaxation1.06678625
60MP0003866_abnormal_defecation1.05754898
61MP0000490_abnormal_crypts_of1.04117171
62MP0000685_abnormal_immune_system1.03160448
63MP0001845_abnormal_inflammatory_respons1.01434414
64MP0010329_abnormal_lipoprotein_level0.99757456
65MP0003300_gastrointestinal_ulcer0.99206444
66MP0004808_abnormal_hematopoietic_stem0.99061305
67MP0003763_abnormal_thymus_physiology0.98497807
68MP0001790_abnormal_immune_system0.96892520
69MP0005387_immune_system_phenotype0.96892520
70MP0009764_decreased_sensitivity_to0.96711882
71MP0005666_abnormal_adipose_tissue0.94235733
72MP0000703_abnormal_thymus_morphology0.93675178
73MP0008874_decreased_physiological_sensi0.91957477
74MP0002733_abnormal_thermal_nociception0.91955155
75MP0009642_abnormal_blood_homeostasis0.91719411
76MP0009697_abnormal_copulation0.90093111
77MP0008260_abnormal_autophagy0.87876848
78MP0005381_digestive/alimentary_phenotyp0.86899915
79MP0001664_abnormal_digestion0.86668156
80MP0005646_abnormal_pituitary_gland0.84305744
81MP0003136_yellow_coat_color0.83726359
82MP0005501_abnormal_skin_physiology0.83205162
83MP0001986_abnormal_taste_sensitivity0.82430338
84MP0001765_abnormal_ion_homeostasis0.82062582
85MP0002998_abnormal_bone_remodeling0.81151317
86MP0006036_abnormal_mitochondrial_physio0.80615343
87MP0009765_abnormal_xenobiotic_induced0.79911689
88MP0005023_abnormal_wound_healing0.75089332
89MP0003453_abnormal_keratinocyte_physiol0.74985568
90MP0002405_respiratory_system_inflammati0.73004822
91MP0000358_abnormal_cell_content/0.69834223
92MP0002019_abnormal_tumor_incidence0.68766046
93MP0003172_abnormal_lysosome_physiology0.67909992
94MP0003183_abnormal_peptide_metabolism0.67471091
95MP0002128_abnormal_blood_circulation0.66841915
96MP0004215_abnormal_myocardial_fiber0.66489160
97MP0003075_altered_response_to0.65642082
98MP0005171_absent_coat_pigmentation0.65610912
99MP0002877_abnormal_melanocyte_morpholog0.65102619
100MP0010368_abnormal_lymphatic_system0.63913933

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)9.79696765
2Petechiae (HP:0000967)9.51549867
3Abnormal platelet volume (HP:0011876)9.38543305
4Purpura (HP:0000979)8.52834074
5Epistaxis (HP:0000421)7.86240196
6Gingival bleeding (HP:0000225)6.44472643
7Hyperlipoproteinemia (HP:0010980)6.06181193
8Abnormal platelet function (HP:0011869)5.68934257
9Impaired platelet aggregation (HP:0003540)5.68934257
10Dyschromatopsia (HP:0007641)4.81989186
11Spontaneous hematomas (HP:0007420)4.39327096
12Acanthocytosis (HP:0001927)4.38444964
13Poikilocytosis (HP:0004447)4.38437656
14Abnormality of the heme biosynthetic pathway (HP:0010472)3.78963087
15Abnormality of the common coagulation pathway (HP:0010990)3.74754263
16Conjunctival telangiectasia (HP:0000524)3.58057225
17Abnormal pupillary function (HP:0007686)3.46710393
18Bruising susceptibility (HP:0000978)3.45537794
19Paralysis (HP:0003470)3.36509671
20Abnormality of the vasculature of the conjunctiva (HP:0008054)3.21202027
21Abnormality of lateral ventricle (HP:0030047)3.12705373
22Abnormality of macrophages (HP:0004311)2.94628544
23Joint hemorrhage (HP:0005261)2.87437128
24Hepatosplenomegaly (HP:0001433)2.87266234
25Increased IgM level (HP:0003496)2.72675749
26Joint swelling (HP:0001386)2.56649927
27Increased density of long bones (HP:0006392)2.51453529
28Decreased central vision (HP:0007663)2.50680759
29Abnormality of iron homeostasis (HP:0011031)2.50040004
30Stomatitis (HP:0010280)2.50033064
31Male infertility (HP:0003251)2.49356093
32Xanthomatosis (HP:0000991)2.48022591
33Upper limb muscle weakness (HP:0003484)2.46050499
34Abnormal auditory evoked potentials (HP:0006958)2.30894392
35Chronic obstructive pulmonary disease (HP:0006510)2.30144267
36Obstructive lung disease (HP:0006536)2.30144267
37Tinnitus (HP:0000360)2.24333998
38Spontaneous abortion (HP:0005268)2.23292855
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.23069351
40Encephalitis (HP:0002383)2.21233865
41Polycythemia (HP:0001901)2.19291423
42Papillary thyroid carcinoma (HP:0002895)2.12580677
43Increased serum ferritin (HP:0003281)2.11846296
44Dysautonomia (HP:0002459)2.10046722
45Hyperthyroidism (HP:0000836)2.07712684
46Abnormality of transition element cation homeostasis (HP:0011030)2.07225459
47Eczematoid dermatitis (HP:0000976)2.05426605
48Episodic fever (HP:0001954)2.04941934
49Nausea (HP:0002018)2.02707721
50Arterial thrombosis (HP:0004420)2.00401507
51Prolonged bleeding time (HP:0003010)11.5285145
52Menorrhagia (HP:0000132)10.0820701
53Hypophosphatemic rickets (HP:0004912)1.95990365
54Autoimmune hemolytic anemia (HP:0001890)1.95167876
55Generalized aminoaciduria (HP:0002909)1.91376925
56Myocardial infarction (HP:0001658)1.88481661
57Thrombocytosis (HP:0001894)1.80167354
58Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.78344432
59Ventricular fibrillation (HP:0001663)1.77507580
60Hypertriglyceridemia (HP:0002155)1.74677261
61Dysostosis multiplex (HP:0000943)1.74126547
62Distal lower limb amyotrophy (HP:0008944)1.67495196
63Hemorrhage of the eye (HP:0011885)1.67485043
64Ileus (HP:0002595)1.65129995
65Basal ganglia calcification (HP:0002135)1.63703444
66Vertigo (HP:0002321)1.63211738
67Biliary tract neoplasm (HP:0100574)1.61318199
68Thyroid-stimulating hormone excess (HP:0002925)1.59184409
69Abnormality of the prostate (HP:0008775)1.57284005
70Recurrent abscess formation (HP:0002722)1.56822851
71Thrombophlebitis (HP:0004418)1.56701247
723-Methylglutaconic aciduria (HP:0003535)1.56240586
73Acute hepatic failure (HP:0006554)1.55241626
74Chest pain (HP:0100749)1.55164557
75Tongue fasciculations (HP:0001308)1.53641554
76Abnormal hemoglobin (HP:0011902)1.53631011
77Granulocytopenia (HP:0001913)1.51722798
78Muscle fibrillation (HP:0010546)1.50861016
79Renal Fanconi syndrome (HP:0001994)1.49624174
80Inflammation of the large intestine (HP:0002037)1.48856859
81Microcytic anemia (HP:0001935)1.48055799
82Exertional dyspnea (HP:0002875)1.44089985
83Abnormal ciliary motility (HP:0012262)1.43159211
84Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.43144038
85Gastrointestinal inflammation (HP:0004386)1.43108415
86Testicular neoplasm (HP:0010788)1.42885684
87Abnormality of the Achilles tendon (HP:0005109)1.42217593
88Panhypogammaglobulinemia (HP:0003139)1.41603678
89Leiomyosarcoma (HP:0100243)1.41454701
90Uterine leiomyosarcoma (HP:0002891)1.41454701
91Gastrointestinal dysmotility (HP:0002579)1.40657107
92Central scotoma (HP:0000603)1.39251339
93Leukocytosis (HP:0001974)1.37558093
94Cerebral ischemia (HP:0002637)1.37461701
95Mucosal telangiectasiae (HP:0100579)1.37116337
96Infertility (HP:0000789)1.36655707
97Thyroid carcinoma (HP:0002890)1.35930740
98Back pain (HP:0003418)1.35309009
99Elevated erythrocyte sedimentation rate (HP:0003565)1.32950445
100Recurrent bacterial skin infections (HP:0005406)1.32213010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.61787676
2MST44.43775877
3BMX4.37653318
4BTK3.25830804
5MYLK3.20022452
6TEC3.19699667
7EIF2AK12.97170311
8PTK2B2.66126946
9CSF1R2.45059872
10ZAP702.40680311
11SYK2.37159396
12GRK62.24639500
13TAOK32.18564177
14PIK3CG2.00131707
15MAP2K31.97858745
16BMPR21.93826143
17ILK1.91021322
18FGR1.80908406
19BLK1.79156915
20GRK51.72480804
21TNK21.63109238
22HCK1.60277813
23FES1.56388972
24STK31.53094351
25ACVR1B1.45634594
26TESK21.31253331
27MATK1.31005961
28LYN1.26945421
29MARK31.24335141
30PAK11.21663904
31IKBKB1.19196633
32TAOK21.18607768
33MAP4K11.18103384
34MAPKAPK31.17293226
35DAPK31.03312425
36ITK0.96804002
37PIM20.93916975
38RET0.93594005
39CSK0.93517583
40SIK30.92242753
41MAP3K110.91335007
42TXK0.91207633
43LMTK20.89391273
44ADRBK20.88239266
45MAP3K50.87068506
46IRAK10.82714941
47IRAK30.81780189
48NUAK10.77291329
49PDPK10.76467899
50PDK10.73314451
51PRKD10.72918108
52PLK20.71069206
53JAK30.70830034
54STK240.70053460
55PNCK0.67954175
56IRAK40.66779668
57MAPK120.64828429
58TLK10.64772625
59ADRBK10.63839181
60LCK0.63684779
61DAPK20.62688126
62MAP3K30.62612239
63PKN10.58567244
64IRAK20.58278834
65MAP2K10.56330783
66BRSK20.54174821
67MAP3K10.53130513
68STK40.50595193
69TAOK10.50379964
70TNIK0.48993327
71ERBB20.46871431
72DAPK10.42574649
73FYN0.41874815
74JAK20.41177524
75PRKACG0.41167678
76PRKCQ0.37088187
77EPHB20.36989304
78DYRK30.36502021
79PDGFRB0.35877705
80DYRK1B0.34839512
81MAP4K20.30998109
82PRKCD0.30446553
83PIM10.30396944
84YES10.29130326
85EPHB10.28740487
86ZAK0.28408887
87ARAF0.26711050
88SIK10.24990988
89MAPK110.24644900
90PRKG10.24226885
91RAF10.24031945
92FER0.24003280
93PRPF4B0.22580228
94FLT30.21744320
95CDK140.21414924
96HIPK20.21091170
97PRKCB0.21074229
98SRC0.20469329
99MAPKAPK20.19933741
100EPHA30.19560210

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046115.64603833
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.32483249
3SNARE interactions in vesicular transport_Homo sapiens_hsa041303.22134376
4Hematopoietic cell lineage_Homo sapiens_hsa046402.56855783
5Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.53874390
6Arachidonic acid metabolism_Homo sapiens_hsa005902.07313174
7ECM-receptor interaction_Homo sapiens_hsa045121.89149806
8Chemokine signaling pathway_Homo sapiens_hsa040621.88296206
9Gap junction_Homo sapiens_hsa045401.77841992
10B cell receptor signaling pathway_Homo sapiens_hsa046621.68884675
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56666685
12Vascular smooth muscle contraction_Homo sapiens_hsa042701.53525946
13Shigellosis_Homo sapiens_hsa051311.47403053
14Nitrogen metabolism_Homo sapiens_hsa009101.44444142
15Endocytosis_Homo sapiens_hsa041441.40208584
16Collecting duct acid secretion_Homo sapiens_hsa049661.36973144
17Systemic lupus erythematosus_Homo sapiens_hsa053221.36268150
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34323917
19Serotonergic synapse_Homo sapiens_hsa047261.33268647
20Alcoholism_Homo sapiens_hsa050341.32753225
21T cell receptor signaling pathway_Homo sapiens_hsa046601.23443419
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22705239
23Primary immunodeficiency_Homo sapiens_hsa053401.17463161
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.13518924
25Osteoclast differentiation_Homo sapiens_hsa043801.12187945
26Malaria_Homo sapiens_hsa051441.11896925
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11188532
28Mismatch repair_Homo sapiens_hsa034301.10388444
29Phospholipase D signaling pathway_Homo sapiens_hsa040721.09944953
30Regulation of actin cytoskeleton_Homo sapiens_hsa048101.09611018
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07018426
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06748727
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06629994
34Pancreatic cancer_Homo sapiens_hsa052121.03750465
35Glutathione metabolism_Homo sapiens_hsa004801.02943926
36Glycerolipid metabolism_Homo sapiens_hsa005611.02680185
37Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98873964
38Pancreatic secretion_Homo sapiens_hsa049720.96686285
39Non-small cell lung cancer_Homo sapiens_hsa052230.92442351
40Staphylococcus aureus infection_Homo sapiens_hsa051500.92308475
41Fatty acid elongation_Homo sapiens_hsa000620.90264010
42Phagosome_Homo sapiens_hsa041450.89404663
43Graft-versus-host disease_Homo sapiens_hsa053320.87200701
44Olfactory transduction_Homo sapiens_hsa047400.81695916
45Viral carcinogenesis_Homo sapiens_hsa052030.81637475
46Sulfur metabolism_Homo sapiens_hsa009200.81211571
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81188192
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.81010637
49Long-term depression_Homo sapiens_hsa047300.77684243
50Leishmaniasis_Homo sapiens_hsa051400.77255017
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75324999
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75030403
53Allograft rejection_Homo sapiens_hsa053300.74984594
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74726995
55Acute myeloid leukemia_Homo sapiens_hsa052210.73264053
56Focal adhesion_Homo sapiens_hsa045100.73072763
57Choline metabolism in cancer_Homo sapiens_hsa052310.72796638
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.72728167
59Asthma_Homo sapiens_hsa053100.69149861
60Autoimmune thyroid disease_Homo sapiens_hsa053200.68918933
61Linoleic acid metabolism_Homo sapiens_hsa005910.68657597
62Rap1 signaling pathway_Homo sapiens_hsa040150.68221965
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65578721
64VEGF signaling pathway_Homo sapiens_hsa043700.65151761
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63616965
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62957739
67Tuberculosis_Homo sapiens_hsa051520.60913037
68Apoptosis_Homo sapiens_hsa042100.60215635
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59791997
70Endometrial cancer_Homo sapiens_hsa052130.59109158
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59060313
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58168462
73Pentose phosphate pathway_Homo sapiens_hsa000300.57235291
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57212744
75Chronic myeloid leukemia_Homo sapiens_hsa052200.56825035
76Salmonella infection_Homo sapiens_hsa051320.56155713
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.55678990
78Renin-angiotensin system_Homo sapiens_hsa046140.55553153
79Lysosome_Homo sapiens_hsa041420.53374997
80Small cell lung cancer_Homo sapiens_hsa052220.53207716
81Calcium signaling pathway_Homo sapiens_hsa040200.50900510
82Sphingolipid metabolism_Homo sapiens_hsa006000.50004571
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.49216500
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49213057
85Ras signaling pathway_Homo sapiens_hsa040140.48048372
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.46973347
87Fat digestion and absorption_Homo sapiens_hsa049750.46453823
88Circadian entrainment_Homo sapiens_hsa047130.46198422
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.46013787
90Legionellosis_Homo sapiens_hsa051340.45565092
91Toxoplasmosis_Homo sapiens_hsa051450.44926758
92Amoebiasis_Homo sapiens_hsa051460.44008411
93Rheumatoid arthritis_Homo sapiens_hsa053230.42812803
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42156403
95Thyroid cancer_Homo sapiens_hsa052160.41917374
96Regulation of autophagy_Homo sapiens_hsa041400.41593527
97Glioma_Homo sapiens_hsa052140.39408654
98Viral myocarditis_Homo sapiens_hsa054160.39153651
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38440158
100Melanoma_Homo sapiens_hsa052180.37981367

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