DDTL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)7.34128479
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.90621747
3viral transcription (GO:0019083)6.67596621
4translational termination (GO:0006415)6.52077212
5energy coupled proton transport, down electrochemical gradient (GO:0015985)6.35422758
6ATP synthesis coupled proton transport (GO:0015986)6.35422758
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.84125033
8cotranslational protein targeting to membrane (GO:0006613)5.74689843
9protein targeting to ER (GO:0045047)5.73189872
10ribosomal large subunit biogenesis (GO:0042273)5.68955235
11establishment of protein localization to endoplasmic reticulum (GO:0072599)5.49417566
12maturation of SSU-rRNA (GO:0030490)5.47803200
13translational elongation (GO:0006414)5.44492069
14protein localization to endoplasmic reticulum (GO:0070972)5.39509466
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.28237521
16respiratory electron transport chain (GO:0022904)5.14278996
17electron transport chain (GO:0022900)5.06872292
18ribosomal small subunit assembly (GO:0000028)5.02243862
19viral life cycle (GO:0019058)4.97495563
20establishment of protein localization to mitochondrial membrane (GO:0090151)4.96479712
21proteasome assembly (GO:0043248)4.91265410
22cellular protein complex disassembly (GO:0043624)4.88407580
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.77863553
24chaperone-mediated protein transport (GO:0072321)4.71597642
25translational initiation (GO:0006413)4.71252860
26termination of RNA polymerase III transcription (GO:0006386)4.49615181
27transcription elongation from RNA polymerase III promoter (GO:0006385)4.49615181
28protein complex biogenesis (GO:0070271)4.49489414
29mitochondrial respiratory chain complex I assembly (GO:0032981)4.41585527
30NADH dehydrogenase complex assembly (GO:0010257)4.41585527
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.41585527
32translation (GO:0006412)4.38036679
33mitochondrial respiratory chain complex assembly (GO:0033108)4.37976799
34DNA replication checkpoint (GO:0000076)4.21330048
35regulation of mitochondrial translation (GO:0070129)4.11688836
36ribonucleoprotein complex biogenesis (GO:0022613)4.06391743
37protein complex disassembly (GO:0043241)3.98862962
38water-soluble vitamin biosynthetic process (GO:0042364)3.94890158
39rRNA modification (GO:0000154)3.93863877
40cellular component biogenesis (GO:0044085)3.90135475
41protein targeting to membrane (GO:0006612)3.79376707
42macromolecular complex disassembly (GO:0032984)3.79296389
43rRNA processing (GO:0006364)3.71461051
44rRNA methylation (GO:0031167)3.66769622
45protein targeting to mitochondrion (GO:0006626)3.64359769
46rRNA metabolic process (GO:0016072)3.58303849
47pseudouridine synthesis (GO:0001522)3.56477212
48ATP biosynthetic process (GO:0006754)3.54651857
49nuclear-transcribed mRNA catabolic process (GO:0000956)3.52145134
50respiratory chain complex IV assembly (GO:0008535)3.50236987
51purine nucleoside triphosphate biosynthetic process (GO:0009145)3.49901153
52pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.44765351
53purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.43720346
54cytochrome complex assembly (GO:0017004)3.43038510
55protein neddylation (GO:0045116)3.34360586
56establishment of protein localization to mitochondrion (GO:0072655)3.32093547
57negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.31886554
58mRNA catabolic process (GO:0006402)3.31246446
59protein localization to mitochondrion (GO:0070585)3.29867134
60hydrogen ion transmembrane transport (GO:1902600)3.26656507
61protein-cofactor linkage (GO:0018065)3.26354767
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15881083
63nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.14504388
64oxidative phosphorylation (GO:0006119)3.14389339
65RNA catabolic process (GO:0006401)3.11286014
66GTP biosynthetic process (GO:0006183)3.09103895
67ribonucleoside triphosphate biosynthetic process (GO:0009201)3.08454117
68negative regulation of ligase activity (GO:0051352)3.04328047
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.04328047
70nucleoside transmembrane transport (GO:1901642)2.97685008
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.97356195
72mitochondrial transport (GO:0006839)2.95343745
73DNA deamination (GO:0045006)2.93759905
74regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.93512205
75intracellular protein transmembrane import (GO:0044743)2.91992637
76spliceosomal snRNP assembly (GO:0000387)2.91317659
77proton transport (GO:0015992)2.89878622
78base-excision repair, AP site formation (GO:0006285)2.85908295
79negative regulation of T cell differentiation in thymus (GO:0033085)2.85534859
80hydrogen transport (GO:0006818)2.84965405
81positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.82048815
82anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81626401
83regulation of cellular amino acid metabolic process (GO:0006521)2.79906929
84transcription elongation from RNA polymerase I promoter (GO:0006362)2.79343262
85aerobic respiration (GO:0009060)2.78519096
86CENP-A containing nucleosome assembly (GO:0034080)2.78389809
87purine nucleoside monophosphate biosynthetic process (GO:0009127)2.77657158
88purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.77657158
89chromatin remodeling at centromere (GO:0031055)2.75560727
90deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.74828553
91regulation of oxidative phosphorylation (GO:0002082)2.74089962
92nucleoside triphosphate biosynthetic process (GO:0009142)2.73337983
93protein targeting (GO:0006605)2.72333157
94UTP biosynthetic process (GO:0006228)2.71170620
95DNA catabolic process, exonucleolytic (GO:0000738)2.69015664
96ncRNA processing (GO:0034470)2.68369639
97establishment of protein localization to membrane (GO:0090150)2.67125618
98pyrimidine nucleotide catabolic process (GO:0006244)2.63472766
99DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.62261361
100vitamin biosynthetic process (GO:0009110)2.60900822

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.94473564
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.81077526
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.46251142
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.29308275
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.94953209
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.84213025
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.49264041
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.21424438
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.18656509
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.96817511
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.92114700
12* VDR_23849224_ChIP-Seq_CD4+_Human2.89635987
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.82601175
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.82534479
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.71334587
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68243928
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.60238851
18* XRN2_22483619_ChIP-Seq_HELA_Human2.57980622
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.48833038
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42754557
21FOXP3_21729870_ChIP-Seq_TREG_Human2.41371339
22DCP1A_22483619_ChIP-Seq_HELA_Human2.38885073
23TTF2_22483619_ChIP-Seq_HELA_Human2.30241777
24ELK1_19687146_ChIP-ChIP_HELA_Human2.25205159
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.19628136
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16352161
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.16130479
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.15397121
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.14109975
30SRF_21415370_ChIP-Seq_HL-1_Mouse2.12249507
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07603973
32E2F7_22180533_ChIP-Seq_HELA_Human2.07144181
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04840041
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98550760
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83295793
36GABP_19822575_ChIP-Seq_HepG2_Human1.73908183
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.67625467
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66105457
39CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.63795149
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61435742
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60456016
42MYC_18940864_ChIP-ChIP_HL60_Human1.58806311
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51344933
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48833497
45BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.48749979
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47295278
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46195469
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45227767
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43885192
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.42559970
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37237099
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35931030
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33324747
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31693409
55KDM5A_27292631_Chip-Seq_BREAST_Human1.30592287
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.26688952
57ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26203782
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25292820
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24588503
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.24340921
61EWS_26573619_Chip-Seq_HEK293_Human1.20550485
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.16755554
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14432623
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14132846
65CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.12166253
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11988528
67CIITA_25753668_ChIP-Seq_RAJI_Human1.09310273
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06431185
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05542921
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02278374
71CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00863750
72CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99675989
73VDR_22108803_ChIP-Seq_LS180_Human0.97860153
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97747122
75TFEB_21752829_ChIP-Seq_HELA_Human0.95969644
76FOXM1_23109430_ChIP-Seq_U2OS_Human0.95635633
77MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94150214
78SPI1_23547873_ChIP-Seq_NB4_Human0.92383907
79FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91158779
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90991849
81ERG_20517297_ChIP-Seq_VCAP_Human0.87959057
82ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85970324
83ELF5_23300383_ChIP-Seq_T47D_Human0.85890389
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84765961
85FOXP1_21924763_ChIP-Seq_HESCs_Human0.83877181
86FOXA1_25329375_ChIP-Seq_VCAP_Human0.81466573
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81466573
88TAF2_19829295_ChIP-Seq_ESCs_Human0.80936215
89IRF8_22096565_ChIP-ChIP_GC-B_Human0.79872437
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79650044
91GATA1_22025678_ChIP-Seq_K562_Human0.78359657
92STAT3_1855785_ChIP-Seq_MESCs_Mouse0.76467051
93AR_20517297_ChIP-Seq_VCAP_Human0.76452469
94GATA3_26560356_Chip-Seq_TH2_Human0.73942062
95RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.71176479
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.70747956
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.70656197
98E2F1_20622854_ChIP-Seq_HELA_Human0.69814527
99TP53_22573176_ChIP-Seq_HFKS_Human0.69722781
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.68466105

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis5.63892828
2MP0009379_abnormal_foot_pigmentation4.38057638
3MP0008875_abnormal_xenobiotic_pharmacok3.43507245
4MP0006036_abnormal_mitochondrial_physio2.93972947
5MP0002139_abnormal_hepatobiliary_system2.82945957
6MP0003693_abnormal_embryo_hatching2.74464094
7MP0003195_calcinosis2.46420517
8MP0008058_abnormal_DNA_repair2.38406758
9MP0004957_abnormal_blastocyst_morpholog2.31712888
10MP0005085_abnormal_gallbladder_physiolo2.23457856
11MP0003186_abnormal_redox_activity2.18749172
12MP0010094_abnormal_chromosome_stability2.15981917
13MP0002837_dystrophic_cardiac_calcinosis2.09506305
14MP0006292_abnormal_olfactory_placode2.06009441
15MP0002277_abnormal_respiratory_mucosa2.04667339
16MP0005332_abnormal_amino_acid2.01017644
17MP0001835_abnormal_antigen_presentation1.97590822
18MP0003111_abnormal_nucleus_morphology1.92653940
19MP0005360_urolithiasis1.89785448
20MP0009697_abnormal_copulation1.89095118
21MP0003786_premature_aging1.88197474
22MP0001764_abnormal_homeostasis1.85083065
23MP0005174_abnormal_tail_pigmentation1.80069873
24MP0003303_peritoneal_inflammation1.78023573
25MP0003718_maternal_effect1.74655647
26MP0003252_abnormal_bile_duct1.72756755
27MP0010386_abnormal_urinary_bladder1.72562797
28MP0002160_abnormal_reproductive_system1.67928055
29MP0006072_abnormal_retinal_apoptosis1.65170267
30MP0003077_abnormal_cell_cycle1.61061452
31MP0005084_abnormal_gallbladder_morpholo1.60205714
32MP0008007_abnormal_cellular_replicative1.59319912
33MP0001986_abnormal_taste_sensitivity1.58232115
34MP0005671_abnormal_response_to1.53823746
35MP0004019_abnormal_vitamin_homeostasis1.52002642
36MP0002876_abnormal_thyroid_physiology1.48248723
37MP0005367_renal/urinary_system_phenotyp1.44925197
38MP0000516_abnormal_urinary_system1.44925197
39MP0005365_abnormal_bile_salt1.44176487
40MP0006035_abnormal_mitochondrial_morpho1.40848441
41MP0005389_reproductive_system_phenotype1.38239837
42MP0002148_abnormal_hypersensitivity_rea1.36962189
43MP0009785_altered_susceptibility_to1.34692116
44MP0000685_abnormal_immune_system1.34255303
45MP0008872_abnormal_physiological_respon1.34171719
46MP0002163_abnormal_gland_morphology1.32869267
47MP0005636_abnormal_mineral_homeostasis1.32786324
48MP0009333_abnormal_splenocyte_physiolog1.27560137
49MP0001756_abnormal_urination1.26890736
50MP0000372_irregular_coat_pigmentation1.24636295
51MP0002938_white_spotting1.20741455
52MP0003136_yellow_coat_color1.15013677
53MP0001800_abnormal_humoral_immune1.11268180
54MP0005379_endocrine/exocrine_gland_phen1.10822166
55MP0002132_abnormal_respiratory_system1.09791714
56MP0003315_abnormal_perineum_morphology1.07094778
57MP0000538_abnormal_urinary_bladder1.05897126
58MP0001919_abnormal_reproductive_system1.04512831
59MP0004142_abnormal_muscle_tone1.00769503
60MP0008873_increased_physiological_sensi1.00619393
61MP0001188_hyperpigmentation1.00024257
62MP0009046_muscle_twitch0.98313737
63MP0008995_early_reproductive_senescence0.96635931
64MP0001881_abnormal_mammary_gland0.94504802
65MP0009764_decreased_sensitivity_to0.94311607
66MP0005075_abnormal_melanosome_morpholog0.92477727
67MP0005387_immune_system_phenotype0.91014480
68MP0001790_abnormal_immune_system0.91014480
69MP0003011_delayed_dark_adaptation0.90453389
70MP0008469_abnormal_protein_level0.89633246
71MP0002452_abnormal_antigen_presenting0.88064895
72MP0001666_abnormal_nutrient_absorption0.87954590
73MP0005319_abnormal_enzyme/_coenzyme0.85674653
74MP0009765_abnormal_xenobiotic_induced0.84239658
75MP0002723_abnormal_immune_serum0.83795829
76MP0001905_abnormal_dopamine_level0.83510188
77MP0005266_abnormal_metabolism0.82212848
78MP0001845_abnormal_inflammatory_respons0.81538061
79MP0001346_abnormal_lacrimal_gland0.81249803
80MP0002638_abnormal_pupillary_reflex0.80568024
81MP0009643_abnormal_urine_homeostasis0.80159706
82MP0001944_abnormal_pancreas_morphology0.79302295
83MP0002138_abnormal_hepatobiliary_system0.79125982
84MP0002693_abnormal_pancreas_physiology0.78511396
85MP0005000_abnormal_immune_tolerance0.77402418
86MP0002095_abnormal_skin_pigmentation0.76673410
87MP0004043_abnormal_pH_regulation0.75506824
88MP0005646_abnormal_pituitary_gland0.74125967
89MP0002019_abnormal_tumor_incidence0.72637519
90MP0008057_abnormal_DNA_replication0.71708051
91MP0000313_abnormal_cell_death0.70594614
92MP0000490_abnormal_crypts_of0.70523773
93MP0008932_abnormal_embryonic_tissue0.70312731
94MP0010155_abnormal_intestine_physiology0.69610901
95MP0005408_hypopigmentation0.67544740
96MP0009763_increased_sensitivity_to0.67484410
97MP0002090_abnormal_vision0.67112263
98MP0000013_abnormal_adipose_tissue0.67031090
99MP0002736_abnormal_nociception_after0.66388299
100MP0001819_abnormal_immune_cell0.65540682

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.05765169
2Mitochondrial inheritance (HP:0001427)4.68038106
3Abnormal mitochondria in muscle tissue (HP:0008316)4.57060510
43-Methylglutaconic aciduria (HP:0003535)4.54178506
5Acute encephalopathy (HP:0006846)4.31860784
6Macrocytic anemia (HP:0001972)4.30580882
7Increased CSF lactate (HP:0002490)4.27786709
8Progressive macrocephaly (HP:0004481)4.25230914
9Increased hepatocellular lipid droplets (HP:0006565)4.24195153
10Abnormal number of erythroid precursors (HP:0012131)4.23784877
11Abnormality of cells of the erythroid lineage (HP:0012130)4.03375763
12Lipid accumulation in hepatocytes (HP:0006561)3.97225345
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.96293454
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.96293454
15Hepatocellular necrosis (HP:0001404)3.82352310
16Hepatic necrosis (HP:0002605)3.68563825
17Renal Fanconi syndrome (HP:0001994)3.67953461
18Hyperalaninemia (HP:0003348)3.53657572
19Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.53657572
20Abnormality of alanine metabolism (HP:0010916)3.53657572
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.50365041
22Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.49080400
23Cerebral edema (HP:0002181)3.37506252
24Reticulocytopenia (HP:0001896)3.34153131
25Increased intramyocellular lipid droplets (HP:0012240)3.29755553
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.24365912
27Pallor (HP:0000980)3.20661773
28Congenital, generalized hypertrichosis (HP:0004540)3.19996279
29Exertional dyspnea (HP:0002875)3.12036835
30Increased serum lactate (HP:0002151)2.98276619
31Lactic acidosis (HP:0003128)2.97932594
32Abnormality of methionine metabolism (HP:0010901)2.96999898
33Increased muscle lipid content (HP:0009058)2.95149110
34Methylmalonic acidemia (HP:0002912)2.92861263
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.88772821
36Exercise intolerance (HP:0003546)2.73056868
37Abnormality of serum amino acid levels (HP:0003112)2.68155598
38Type I transferrin isoform profile (HP:0003642)2.63848272
39Respiratory failure (HP:0002878)2.61278841
40Methylmalonic aciduria (HP:0012120)2.58353716
41Aplastic anemia (HP:0001915)2.56612139
42Lethargy (HP:0001254)2.55700690
43Megaloblastic anemia (HP:0001889)2.54787925
44Abnormality of homocysteine metabolism (HP:0010919)2.54638824
45Homocystinuria (HP:0002156)2.54638824
46Glycosuria (HP:0003076)2.53221776
47Abnormality of urine glucose concentration (HP:0011016)2.53221776
48Abnormality of aspartate family amino acid metabolism (HP:0010899)2.52657385
49Generalized aminoaciduria (HP:0002909)2.46679492
50Abnormality of renal resorption (HP:0011038)2.44782905
51Respiratory difficulties (HP:0002880)2.44251322
52Oral leukoplakia (HP:0002745)2.43075428
53Reduced antithrombin III activity (HP:0001976)2.39828604
54Prolonged partial thromboplastin time (HP:0003645)2.33469950
55Optic disc pallor (HP:0000543)2.27454300
56Birth length less than 3rd percentile (HP:0003561)2.25437577
57Leukodystrophy (HP:0002415)2.25278971
58Testicular atrophy (HP:0000029)2.16671420
59Rectal fistula (HP:0100590)2.16652035
60Rectovaginal fistula (HP:0000143)2.16652035
61Metabolic acidosis (HP:0001942)2.14919751
62Microretrognathia (HP:0000308)2.14407584
63Congenital ichthyosiform erythroderma (HP:0007431)2.12099438
64Abnormality of placental membranes (HP:0011409)2.11776294
65Amniotic constriction ring (HP:0009775)2.11776294
66Cleft eyelid (HP:0000625)2.10563575
67Paralysis (HP:0003470)2.00623809
68Abnormality of sulfur amino acid metabolism (HP:0004339)2.00221236
69Hyperphosphaturia (HP:0003109)2.00169304
70Absent thumb (HP:0009777)1.99538079
71Increased serum pyruvate (HP:0003542)1.99210372
72Abnormality of vitamin B metabolism (HP:0004340)1.98897846
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96632932
74Abnormal protein N-linked glycosylation (HP:0012347)1.96632932
75Abnormal protein glycosylation (HP:0012346)1.96632932
76Abnormal glycosylation (HP:0012345)1.96632932
77Abnormality of aromatic amino acid family metabolism (HP:0004338)1.96374821
78Poor head control (HP:0002421)1.94514321
79Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94093559
80Dicarboxylic aciduria (HP:0003215)1.94093559
81Nausea (HP:0002018)1.87879968
82Abnormality of the vitamin B12 metabolism (HP:0004341)1.85798932
83Vaginal fistula (HP:0004320)1.82532716
84Anorexia (HP:0002039)1.81201208
85CNS demyelination (HP:0007305)1.81167288
86Hyperglycinemia (HP:0002154)1.80489932
87Intestinal fistula (HP:0100819)1.80147620
88Renal tubular dysfunction (HP:0000124)1.80142470
89IgG deficiency (HP:0004315)1.78935623
90Tinnitus (HP:0000360)1.78817935
91Hypobetalipoproteinemia (HP:0003563)1.77717385
92Decreased subcutaneous fat (HP:0001002)1.77687412
93Parakeratosis (HP:0001036)1.77469762
94Degeneration of anterior horn cells (HP:0002398)1.76482662
95Abnormality of the anterior horn cell (HP:0006802)1.76482662
96Pancreatic cysts (HP:0001737)1.73518249
97Opisthotonus (HP:0002179)1.72500236
98Abnormal urine phosphate concentration (HP:0012599)1.71559345
99Confusion (HP:0001289)1.71087308
100Sensory axonal neuropathy (HP:0003390)1.69978310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.88925559
2BUB14.63991761
3STK164.24211411
4NME23.32552369
5VRK23.23694302
6MST42.79798352
7ZAK2.52856046
8NUAK12.01685209
9CDK191.94170129
10EIF2AK11.92526907
11TESK21.79521630
12ADRBK21.74381112
13NME11.73995225
14MAP3K121.73943301
15CDC71.70981207
16SRPK11.69984322
17PDK21.64136525
18VRK11.57884116
19EIF2AK31.56707529
20WNK41.53387483
21PLK41.49528903
22IKBKB1.35309539
23BMPR1B1.24230654
24BLK1.22481720
25FRK1.21715416
26PHKG11.17997746
27PHKG21.17997746
28INSRR1.17092362
29GRK61.14249896
30PBK1.11825071
31GRK11.10624872
32MYLK1.08937219
33ABL21.06068584
34BCKDK1.05822309
35OXSR11.02527167
36BMPR20.98135222
37ILK0.90622822
38PLK10.89856396
39TAOK30.86050703
40MUSK0.83411312
41STK30.83107636
42AURKB0.82684874
43DYRK20.82592446
44PLK30.82443508
45RPS6KA50.81562092
46CCNB10.81420424
47TNIK0.80062308
48MAP2K60.77160950
49NEK10.77134961
50RPS6KB20.76049206
51SCYL20.75638605
52PASK0.73586246
53CHEK20.73150285
54CSNK2A10.72996603
55WNK30.72572295
56MATK0.71399058
57DYRK30.71013278
58TTK0.70547189
59CDK80.69952150
60MAP4K20.69359428
61CSNK2A20.68109533
62ARAF0.68096633
63ACVR1B0.65174717
64RIPK40.64963322
65ATR0.64287379
66STK240.64073470
67LYN0.63012327
68NEK20.61575426
69TXK0.59398165
70TEC0.58507097
71MKNK20.56905800
72MAP2K30.56878917
73TRIM280.55541617
74SYK0.54430649
75CSNK1G30.54328078
76TAF10.53407137
77MAP2K20.53032921
78MAPK150.50858213
79PIM20.50726012
80MKNK10.50028502
81ADRBK10.49364036
82STK390.48795554
83EIF2AK20.47452216
84DAPK30.46461424
85ERN10.46221827
86GRK70.44299802
87PRKCI0.44266350
88IKBKE0.43873783
89CSNK1G10.43221396
90CDK30.43164568
91PIM10.43084574
92MAPKAPK30.39118600
93BRSK20.38546778
94NEK90.37525774
95CDK70.36075417
96MARK30.35488624
97STK40.31134021
98MAPKAPK50.30089152
99CDK40.29741716
100CHEK10.26537115

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.32924317
2Oxidative phosphorylation_Homo sapiens_hsa001904.18262735
3Parkinsons disease_Homo sapiens_hsa050123.39056554
4Proteasome_Homo sapiens_hsa030503.38234255
5RNA polymerase_Homo sapiens_hsa030202.82498231
6Asthma_Homo sapiens_hsa053102.67084782
7Huntingtons disease_Homo sapiens_hsa050162.37117276
8Protein export_Homo sapiens_hsa030602.22374455
9Alzheimers disease_Homo sapiens_hsa050102.19756959
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.17874463
11Homologous recombination_Homo sapiens_hsa034402.13595779
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.12139897
13DNA replication_Homo sapiens_hsa030302.06821743
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.96797727
15One carbon pool by folate_Homo sapiens_hsa006701.96010462
16Mismatch repair_Homo sapiens_hsa034301.90988928
17Allograft rejection_Homo sapiens_hsa053301.77514753
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73026326
19Autoimmune thyroid disease_Homo sapiens_hsa053201.59875428
20Pyrimidine metabolism_Homo sapiens_hsa002401.57525318
21Nucleotide excision repair_Homo sapiens_hsa034201.56939098
22Type I diabetes mellitus_Homo sapiens_hsa049401.52384043
23Sulfur relay system_Homo sapiens_hsa041221.50927024
24Base excision repair_Homo sapiens_hsa034101.44040342
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39486937
26Graft-versus-host disease_Homo sapiens_hsa053321.38404963
27Cardiac muscle contraction_Homo sapiens_hsa042601.35149290
28Spliceosome_Homo sapiens_hsa030401.34053190
29Basal transcription factors_Homo sapiens_hsa030221.31199825
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28011428
31Collecting duct acid secretion_Homo sapiens_hsa049661.19517176
32Sulfur metabolism_Homo sapiens_hsa009201.18866690
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.18526290
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.12835975
35Chemical carcinogenesis_Homo sapiens_hsa052041.11158954
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09438909
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08596569
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06709509
39Vitamin digestion and absorption_Homo sapiens_hsa049771.05706564
40RNA degradation_Homo sapiens_hsa030181.05561849
41Fanconi anemia pathway_Homo sapiens_hsa034601.05485027
42Rheumatoid arthritis_Homo sapiens_hsa053231.04493721
43Staphylococcus aureus infection_Homo sapiens_hsa051501.03152701
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01485410
45Caffeine metabolism_Homo sapiens_hsa002321.00985790
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96565500
47RNA transport_Homo sapiens_hsa030130.95531009
48Tryptophan metabolism_Homo sapiens_hsa003800.93923356
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92727346
50Purine metabolism_Homo sapiens_hsa002300.91708118
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.88831445
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87625870
53Systemic lupus erythematosus_Homo sapiens_hsa053220.87181394
54Retinol metabolism_Homo sapiens_hsa008300.84458967
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81953299
56Pyruvate metabolism_Homo sapiens_hsa006200.79628657
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79016342
58Glutathione metabolism_Homo sapiens_hsa004800.76509766
59Antigen processing and presentation_Homo sapiens_hsa046120.75750988
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.73714395
61Metabolic pathways_Homo sapiens_hsa011000.72068708
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70693626
63Non-homologous end-joining_Homo sapiens_hsa034500.69042214
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66172912
65Folate biosynthesis_Homo sapiens_hsa007900.64347498
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63691301
67Fatty acid elongation_Homo sapiens_hsa000620.63570651
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62093185
69Peroxisome_Homo sapiens_hsa041460.61871537
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.61780266
71Fatty acid degradation_Homo sapiens_hsa000710.58102929
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56780610
73Viral myocarditis_Homo sapiens_hsa054160.56269783
74Regulation of autophagy_Homo sapiens_hsa041400.56127947
75beta-Alanine metabolism_Homo sapiens_hsa004100.51977502
76Tyrosine metabolism_Homo sapiens_hsa003500.51613103
77Leishmaniasis_Homo sapiens_hsa051400.50709313
78Epstein-Barr virus infection_Homo sapiens_hsa051690.46434537
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45522727
80Selenocompound metabolism_Homo sapiens_hsa004500.44984561
81Nitrogen metabolism_Homo sapiens_hsa009100.43985308
82Propanoate metabolism_Homo sapiens_hsa006400.42597105
83Linoleic acid metabolism_Homo sapiens_hsa005910.41116529
84Phenylalanine metabolism_Homo sapiens_hsa003600.41069666
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40773772
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39616188
87Arachidonic acid metabolism_Homo sapiens_hsa005900.39083530
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34811296
89Primary immunodeficiency_Homo sapiens_hsa053400.34556719
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32630073
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.31848394
92Histidine metabolism_Homo sapiens_hsa003400.29424833
93Fat digestion and absorption_Homo sapiens_hsa049750.28804615
94Herpes simplex infection_Homo sapiens_hsa051680.26284246
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25911322
96Cell cycle_Homo sapiens_hsa041100.25053629
97Butanoate metabolism_Homo sapiens_hsa006500.22729433
98Mineral absorption_Homo sapiens_hsa049780.19921486
99Arginine biosynthesis_Homo sapiens_hsa002200.18968938
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16211604

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »