DDO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.34031444
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.34031444
3lysine catabolic process (GO:0006554)5.25220874
4lysine metabolic process (GO:0006553)5.25220874
5L-phenylalanine metabolic process (GO:0006558)5.17788417
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.17788417
7aromatic amino acid family catabolic process (GO:0009074)4.73601408
8amino-acid betaine metabolic process (GO:0006577)4.58066021
9glyoxylate metabolic process (GO:0046487)4.54689910
10short-chain fatty acid metabolic process (GO:0046459)4.52333341
11fatty acid beta-oxidation (GO:0006635)4.52083672
12fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.51924194
13alpha-linolenic acid metabolic process (GO:0036109)4.51408983
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.47418131
15cellular ketone body metabolic process (GO:0046950)4.43676786
16kynurenine metabolic process (GO:0070189)4.37001103
17carnitine metabolic process (GO:0009437)4.31912316
18tryptophan catabolic process (GO:0006569)4.28478536
19indole-containing compound catabolic process (GO:0042436)4.28478536
20indolalkylamine catabolic process (GO:0046218)4.28478536
212-oxoglutarate metabolic process (GO:0006103)4.26882307
22carnitine shuttle (GO:0006853)4.21014531
23fatty acid transmembrane transport (GO:1902001)4.20645047
24fatty acid oxidation (GO:0019395)4.20302222
25lipid oxidation (GO:0034440)4.17981684
26cysteine metabolic process (GO:0006534)4.16804027
27* aspartate family amino acid catabolic process (GO:0009068)4.13434918
28fatty acid catabolic process (GO:0009062)4.10076991
29tryptophan metabolic process (GO:0006568)4.06698885
30bile acid biosynthetic process (GO:0006699)4.04654383
31acetyl-CoA metabolic process (GO:0006084)3.98774311
32regulation of triglyceride catabolic process (GO:0010896)3.91771848
33serine family amino acid catabolic process (GO:0009071)3.88487133
34monocarboxylic acid catabolic process (GO:0072329)3.86973710
35valine metabolic process (GO:0006573)3.85261379
36branched-chain amino acid catabolic process (GO:0009083)3.82509691
37sulfur amino acid catabolic process (GO:0000098)3.82027034
38tricarboxylic acid cycle (GO:0006099)3.81802056
39ketone body metabolic process (GO:1902224)3.81575641
40ethanol oxidation (GO:0006069)3.79309717
41fibrinolysis (GO:0042730)3.79249685
42homocysteine metabolic process (GO:0050667)3.77616335
43* alpha-amino acid catabolic process (GO:1901606)3.75388909
44positive regulation of lipoprotein lipase activity (GO:0051006)3.75356373
45positive regulation of triglyceride lipase activity (GO:0061365)3.75356373
46dicarboxylic acid biosynthetic process (GO:0043650)3.66054263
47branched-chain amino acid metabolic process (GO:0009081)3.63521739
48epoxygenase P450 pathway (GO:0019373)3.59690542
49* cellular amino acid catabolic process (GO:0009063)3.58768259
50biotin metabolic process (GO:0006768)3.58643513
51positive regulation of fatty acid beta-oxidation (GO:0032000)3.57176285
52high-density lipoprotein particle remodeling (GO:0034375)3.56372914
53exogenous drug catabolic process (GO:0042738)3.55070858
54oligosaccharide catabolic process (GO:0009313)3.54101119
55cellular modified amino acid catabolic process (GO:0042219)3.52977397
56positive regulation of fatty acid biosynthetic process (GO:0045723)3.50856748
57glutamate metabolic process (GO:0006536)3.50620020
58amino-acid betaine transport (GO:0015838)3.49593584
59carnitine transport (GO:0015879)3.49593584
60* organic acid catabolic process (GO:0016054)3.49587690
61* carboxylic acid catabolic process (GO:0046395)3.49587690
62carnitine transmembrane transport (GO:1902603)3.47841181
63regulation of sequestering of triglyceride (GO:0010889)3.46608933
64bile acid metabolic process (GO:0008206)3.46592251
65reverse cholesterol transport (GO:0043691)3.45394324
66urea cycle (GO:0000050)3.42821174
67urea metabolic process (GO:0019627)3.42821174
68succinate metabolic process (GO:0006105)3.42103320
69aromatic amino acid family metabolic process (GO:0009072)3.41338755
70positive regulation of fatty acid oxidation (GO:0046321)3.40996983
71regulation of cholesterol esterification (GO:0010872)3.38503831
72coenzyme catabolic process (GO:0009109)3.37800641
73tricarboxylic acid metabolic process (GO:0072350)3.36272047
74regulation of fatty acid oxidation (GO:0046320)3.36263312
75blood coagulation, intrinsic pathway (GO:0007597)3.35540660
76protein carboxylation (GO:0018214)3.34277186
77peptidyl-glutamic acid carboxylation (GO:0017187)3.34277186
78triglyceride homeostasis (GO:0070328)3.33339924
79acylglycerol homeostasis (GO:0055090)3.33339924
80protein-lipid complex remodeling (GO:0034368)3.28543484
81macromolecular complex remodeling (GO:0034367)3.28543484
82plasma lipoprotein particle remodeling (GO:0034369)3.28543484
83phospholipid homeostasis (GO:0055091)3.23374632
84drug catabolic process (GO:0042737)3.23055589
85regulation of protein activation cascade (GO:2000257)3.19681464
86nitrogen cycle metabolic process (GO:0071941)3.19440278
87complement activation, alternative pathway (GO:0006957)3.18907021
88negative regulation of hemostasis (GO:1900047)3.17670922
89negative regulation of blood coagulation (GO:0030195)3.17670922
90negative regulation of sterol transport (GO:0032372)3.16910589
91negative regulation of cholesterol transport (GO:0032375)3.16910589
92acute-phase response (GO:0006953)3.15340460
93tyrosine metabolic process (GO:0006570)3.15178041
94positive regulation of lipid catabolic process (GO:0050996)3.13467637
95cholesterol efflux (GO:0033344)3.13319250
96regulation of cholesterol metabolic process (GO:0090181)3.12481234
97ethanol metabolic process (GO:0006067)3.10893411
98quaternary ammonium group transport (GO:0015697)3.09442420
99negative regulation of fibrinolysis (GO:0051918)3.09386352
100fatty acid homeostasis (GO:0055089)3.09064115
101indolalkylamine metabolic process (GO:0006586)3.07871252
102low-density lipoprotein particle remodeling (GO:0034374)3.07549792
103drug transmembrane transport (GO:0006855)3.06301676
104omega-hydroxylase P450 pathway (GO:0097267)3.05465097
105plasma lipoprotein particle clearance (GO:0034381)3.05254285
106regulation of fibrinolysis (GO:0051917)3.04500523
107positive regulation of lipid storage (GO:0010884)3.04154837
108regulation of cholesterol storage (GO:0010885)3.03326058
109regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.03036902
110phospholipid efflux (GO:0033700)3.02497846
111NADH metabolic process (GO:0006734)3.02413344
112drug metabolic process (GO:0017144)3.02161119
113xenobiotic catabolic process (GO:0042178)3.01196702
114regulation of complement activation (GO:0030449)2.99681043
115cellular glucuronidation (GO:0052695)2.98288378
116negative regulation of protein activation cascade (GO:2000258)2.96313626
117uronic acid metabolic process (GO:0006063)2.95804863
118glucuronate metabolic process (GO:0019585)2.95804863
119very-low-density lipoprotein particle assembly (GO:0034379)2.95081413
120fat-soluble vitamin biosynthetic process (GO:0042362)2.94693203
121* small molecule catabolic process (GO:0044282)2.94425917
122cellular biogenic amine catabolic process (GO:0042402)2.94143670
123amine catabolic process (GO:0009310)2.94143670
124benzene-containing compound metabolic process (GO:0042537)2.92592181
125glucosamine-containing compound catabolic process (GO:1901072)2.92358470
126negative regulation of coagulation (GO:0050819)2.92046523
127regulation of fatty acid beta-oxidation (GO:0031998)2.91017144
128positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.84854807
129negative regulation of complement activation (GO:0045916)2.74749933
130muscle filament sliding (GO:0030049)2.73538000
131actin-myosin filament sliding (GO:0033275)2.73538000
132negative regulation of wound healing (GO:0061045)2.70264187
133creatine metabolic process (GO:0006600)2.70211722
134oxaloacetate metabolic process (GO:0006107)2.68818879
135regulation of apoptotic cell clearance (GO:2000425)2.68793303
136regulation of humoral immune response (GO:0002920)2.65888658
137response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.65308547
138protein activation cascade (GO:0072376)2.63157984
139positive regulation of hemostasis (GO:1900048)2.62994770
140positive regulation of blood coagulation (GO:0030194)2.62994770
141response to muscle activity (GO:0014850)2.62450902
142regulation of fatty acid biosynthetic process (GO:0042304)2.58539785
143regulation of skeletal muscle contraction (GO:0014819)2.57069840
144sarcoplasmic reticulum calcium ion transport (GO:0070296)2.54931292
145positive regulation of chemokine secretion (GO:0090197)2.52742773
146plasma lipoprotein particle organization (GO:0071827)2.52620828
147low-density lipoprotein particle clearance (GO:0034383)2.51809164
148amino sugar catabolic process (GO:0046348)2.51682049
149plasma lipoprotein particle assembly (GO:0034377)2.50937021
150positive regulation of coagulation (GO:0050820)2.48625036
151protein-lipid complex subunit organization (GO:0071825)2.48322429
152negative regulation of lipase activity (GO:0060192)2.47791628

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.66850305
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.58359839
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.52081022
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.99894671
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.91345192
6PPARA_22158963_ChIP-Seq_LIVER_Mouse4.74591064
7LXR_22158963_ChIP-Seq_LIVER_Mouse4.57134487
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.84268151
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.77315795
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.41745789
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.20052572
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.66583469
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.51189466
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.47970505
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.06083987
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.05062939
17ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.99495132
18IRF8_27001747_Chip-Seq_BMDM_Mouse1.96967546
19* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96786983
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86735367
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.80633876
22GATA1_22025678_ChIP-Seq_K562_Human1.71618557
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66412779
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.64626670
25EP300_21415370_ChIP-Seq_HL-1_Mouse1.61785504
26TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.60708387
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60339747
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.59146024
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.55760651
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.52789279
31FOXA2_19822575_ChIP-Seq_HepG2_Human1.52697035
32CLOCK_20551151_ChIP-Seq_293T_Human1.51352736
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50394520
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37219747
35VDR_24787735_ChIP-Seq_THP-1_Human1.36615441
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36128479
37TBX20_22328084_ChIP-Seq_HEART_Mouse1.34395422
38TBX20_22080862_ChIP-Seq_HEART_Mouse1.34395422
39SCL_19346495_ChIP-Seq_HPC-7_Human1.33314884
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30987519
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30400014
42GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29728623
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.29490255
44CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24219903
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23848490
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21170408
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21041871
48RUNX_20019798_ChIP-Seq_JUKART_Human1.14782517
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13219615
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12827508
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12827508
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.12696590
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11951876
54* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08860845
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08719865
56BCAT_22108803_ChIP-Seq_LS180_Human1.07951813
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07037369
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.06776978
59TRIM28_21343339_ChIP-Seq_HEK293_Human1.06711866
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.06030846
61HNF4A_19822575_ChIP-Seq_HepG2_Human1.03982181
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03202621
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03185468
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03104290
65HTT_18923047_ChIP-ChIP_STHdh_Human1.02734506
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02128231
67PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99836755
68DROSHA_22980978_ChIP-Seq_HELA_Human0.99773069
69SOX2_20726797_ChIP-Seq_SW620_Human0.98924957
70GBX2_23144817_ChIP-Seq_PC3_Human0.98283540
71* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94891457
72ZNF263_19887448_ChIP-Seq_K562_Human0.93963744
73SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.93778320
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93437309
75AR_21572438_ChIP-Seq_LNCaP_Human0.93058299
76JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92880293
77STAT1_20625510_ChIP-Seq_HELA_Human0.92305983
78AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91215164
79SPI1_23127762_ChIP-Seq_K562_Human0.91112781
80MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90051233
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89969753
82IGF1R_20145208_ChIP-Seq_DFB_Human0.89477395
83MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.88825272
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86176928
85SMAD_19615063_ChIP-ChIP_OVARY_Human0.84593510
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84422823
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.83408229
88EZH2_22144423_ChIP-Seq_EOC_Human0.82445182
89PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82136565
90RXR_22108803_ChIP-Seq_LS180_Human0.81924281
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81670922
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81108066
93CEBPB_22108803_ChIP-Seq_LS180_Human0.79765450
94SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.79483251
95SMAD4_21741376_ChIP-Seq_HESCs_Human0.79441976
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.78838804
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78423115
98SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.78233783
99CJUN_26792858_Chip-Seq_BT549_Human0.78040741
100SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77660464
101SOX2_27498859_Chip-Seq_STOMACH_Mouse0.77493244
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77189196
103BRD4_27068464_Chip-Seq_AML-cells_Mouse0.76882400
104TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.76601981
105ESR1_21235772_ChIP-Seq_MCF-7_Human0.74428255
106JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73001569
107CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72474421
108EED_16625203_ChIP-ChIP_MESCs_Mouse0.72118120
109SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.71918429
110ZNF217_24962896_ChIP-Seq_MCF-7_Human0.71715690
111AR_20517297_ChIP-Seq_VCAP_Human0.70761555
112EZH2_27294783_Chip-Seq_ESCs_Mouse0.70312090
113SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69902767
114SMAD4_21799915_ChIP-Seq_A2780_Human0.69270872
115EZH2_18974828_ChIP-Seq_MESCs_Mouse0.69213640
116RNF2_18974828_ChIP-Seq_MESCs_Mouse0.69213640
117CBP_21632823_ChIP-Seq_H3396_Human0.68976532
118NR3C1_23031785_ChIP-Seq_PC12_Mouse0.68745547
119ER_23166858_ChIP-Seq_MCF-7_Human0.68533744
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67977747
121BCL6_27268052_Chip-Seq_Bcells_Human0.67861698
122ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.67857802
123PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.67410110
124GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66880697
125TAF15_26573619_Chip-Seq_HEK293_Human0.66801458
126* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.66607074
127GATA4_25053715_ChIP-Seq_YYC3_Human0.66350488
128PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.66182391
129GATA2_19941826_ChIP-Seq_K562_Human0.65837742
130SOX2_21211035_ChIP-Seq_LN229_Gbm0.65391244
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.64689024
132RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64534702
133PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.63879499
134SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.63492558
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.63457520
136CBP_20019798_ChIP-Seq_JUKART_Human0.63457520
137TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.63333192
138NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.62995552
139BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62986781
140GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.62790271
141SMAD3_21741376_ChIP-Seq_HESCs_Human0.62189816
142* SMAD4_21741376_ChIP-Seq_EPCs_Human0.61514649
143UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.61136862
144PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.60555269
145SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.60473233
146AR_25329375_ChIP-Seq_VCAP_Human0.60186514
147MYC_27129775_Chip-Seq_CORNEA_Mouse0.59943712
148* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.59870300
149JARID2_20075857_ChIP-Seq_MESCs_Mouse0.59195019
150ARNT_22903824_ChIP-Seq_MCF-7_Human0.59188951
151SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.58937348
152FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.58871430
153CDX2_22108803_ChIP-Seq_LS180_Human0.58503156
154PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.58463211
155* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.57851910
156ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.57278165
157GATA1_19941826_ChIP-Seq_K562_Human0.57227643
158CTCF_27219007_Chip-Seq_Bcells_Human0.56554419

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.91603207
2MP0005360_urolithiasis5.36902931
3MP0005085_abnormal_gallbladder_physiolo4.70447600
4MP0005365_abnormal_bile_salt4.62239264
5MP0008875_abnormal_xenobiotic_pharmacok3.61713766
6MP0002837_dystrophic_cardiac_calcinosis3.55192085
7MP0003646_muscle_fatigue3.09042804
8MP0003806_abnormal_nucleotide_metabolis3.03610538
9MP0003252_abnormal_bile_duct2.82718253
10MP0010329_abnormal_lipoprotein_level2.81507579
11* MP0005332_abnormal_amino_acid2.72524734
12MP0003195_calcinosis2.57565806
13MP0004130_abnormal_muscle_cell2.43423115
14MP0005083_abnormal_biliary_tract2.34994333
15MP0005670_abnormal_white_adipose2.32064343
16MP0009840_abnormal_foam_cell2.29091086
17MP0000751_myopathy2.18541951
18MP0004215_abnormal_myocardial_fiber2.17670701
19MP0001666_abnormal_nutrient_absorption2.05523256
20MP0002118_abnormal_lipid_homeostasis2.01571550
21MP0003303_peritoneal_inflammation1.93017738
22MP0004084_abnormal_cardiac_muscle1.87181659
23MP0005330_cardiomyopathy1.84246309
24MP0004036_abnormal_muscle_relaxation1.83984335
25MP0006036_abnormal_mitochondrial_physio1.83885404
26MP0004043_abnormal_pH_regulation1.83701108
27MP0005058_abnormal_lysosome_morphology1.78737254
28MP0003724_increased_susceptibility_to1.75862975
29MP0000749_muscle_degeneration1.75576028
30MP0004019_abnormal_vitamin_homeostasis1.73948275
31MP0005319_abnormal_enzyme/_coenzyme1.62975893
32MP0005584_abnormal_enzyme/coenzyme_acti1.61800025
33MP0000609_abnormal_liver_physiology1.57442720
34MP0001835_abnormal_antigen_presentation1.56594480
35MP0005666_abnormal_adipose_tissue1.54057345
36MP0003191_abnormal_cellular_cholesterol1.53515118
37MP0009785_altered_susceptibility_to1.50815039
38MP0002138_abnormal_hepatobiliary_system1.46223313
39MP0005464_abnormal_platelet_physiology1.45368456
40MP0009643_abnormal_urine_homeostasis1.45026774
41MP0002148_abnormal_hypersensitivity_rea1.44162481
42MP0002972_abnormal_cardiac_muscle1.39674998
43MP0002971_abnormal_brown_adipose1.38690329
44MP0003137_abnormal_impulse_conducting1.36804146
45MP0005620_abnormal_muscle_contractility1.35990013
46MP0003436_decreased_susceptibility_to1.34275811
47MP0004087_abnormal_muscle_fiber1.32040732
48MP0008469_abnormal_protein_level1.30829453
49MP0003879_abnormal_hair_cell1.27676491
50MP0003300_gastrointestinal_ulcer1.26477523
51MP0003690_abnormal_glial_cell1.26019461
52MP0000343_altered_response_to1.25852814
53MP0003868_abnormal_feces_composition1.25626130
54MP0005535_abnormal_body_temperature1.23911269
55MP0008775_abnormal_heart_ventricle1.23047968
56MP0002078_abnormal_glucose_homeostasis1.20853501
57MP0002269_muscular_atrophy1.19449057
58MP0004510_myositis1.19210368
59MP0006082_CNS_inflammation1.18239864
60MP0002419_abnormal_innate_immunity1.17776258
61MP0003950_abnormal_plasma_membrane1.14140959
62MP0003186_abnormal_redox_activity1.12787632
63MP0005385_cardiovascular_system_phenoty1.11804792
64MP0001544_abnormal_cardiovascular_syste1.11804792
65MP0004145_abnormal_muscle_electrophysio1.08390805
66MP0001764_abnormal_homeostasis1.05513915
67MP0006138_congestive_heart_failure1.05226500
68MP0003172_abnormal_lysosome_physiology1.03461358
69MP0000747_muscle_weakness1.02492358
70MP0006035_abnormal_mitochondrial_morpho1.02181834
71MP0009697_abnormal_copulation1.02067871
72MP0005166_decreased_susceptibility_to1.00469794
73MP0005636_abnormal_mineral_homeostasis1.00452408
74MP0005025_abnormal_response_to0.99791156
75MP0002106_abnormal_muscle_physiology0.99631525
76MP0000750_abnormal_muscle_regeneration0.99493209
77MP0005387_immune_system_phenotype0.98849364
78MP0001790_abnormal_immune_system0.98849364
79MP0009780_abnormal_chondrocyte_physiolo0.98543129
80MP0002876_abnormal_thyroid_physiology0.97815506
81MP0004484_altered_response_of0.95691312
82MP0004085_abnormal_heartbeat0.93708023
83MP0002332_abnormal_exercise_endurance0.93057429
84MP0005334_abnormal_fat_pad0.92617714
85MP0010630_abnormal_cardiac_muscle0.91245339
86MP0000685_abnormal_immune_system0.89555299
87MP0000230_abnormal_systemic_arterial0.88060378
88MP0001845_abnormal_inflammatory_respons0.88031366
89MP0003329_amyloid_beta_deposits0.87019900
90MP0004233_abnormal_muscle_weight0.86092176
91MP0003828_pulmonary_edema0.85856213
92MP0001533_abnormal_skeleton_physiology0.85780742
93MP0005266_abnormal_metabolism0.84897725
94MP0005375_adipose_tissue_phenotype0.84479332
95MP0005000_abnormal_immune_tolerance0.84372785
96MP0005451_abnormal_body_composition0.83992976
97MP0003183_abnormal_peptide_metabolism0.83877400
98MP0002132_abnormal_respiratory_system0.83363385
99MP0001756_abnormal_urination0.83016375
100MP0005165_increased_susceptibility_to0.82446525
101MP0005369_muscle_phenotype0.80534505
102MP0005164_abnormal_response_to0.78274775
103MP0000249_abnormal_blood_vessel0.77758475
104MP0001765_abnormal_ion_homeostasis0.76411163
105MP0005647_abnormal_sex_gland0.75338241
106MP0005448_abnormal_energy_balance0.74705704
107MP0000604_amyloidosis0.74048980
108MP0009642_abnormal_blood_homeostasis0.73851105
109MP0002909_abnormal_adrenal_gland0.73799583
110MP0009764_decreased_sensitivity_to0.73296527
111MP0004185_abnormal_adipocyte_glucose0.71889734
112MP0000759_abnormal_skeletal_muscle0.71603796
113MP0009384_cardiac_valve_regurgitation0.70847997
114MP0010368_abnormal_lymphatic_system0.70589821
115MP0002254_reproductive_system_inflammat0.69186909
116MP0009115_abnormal_fat_cell0.66983905
117MP0005167_abnormal_blood-brain_barrier0.66499649
118MP0003656_abnormal_erythrocyte_physiolo0.65922124
119MP0003953_abnormal_hormone_level0.65556101
120MP0003011_delayed_dark_adaptation0.64301588
121MP0005376_homeostasis/metabolism_phenot0.63906100
122MP0005084_abnormal_gallbladder_morpholo0.62277626
123MP0001853_heart_inflammation0.61465001
124MP0000598_abnormal_liver_morphology0.60971236
125MP0001661_extended_life_span0.58959243
126MP0005220_abnormal_exocrine_pancreas0.56073658
127MP0003221_abnormal_cardiomyocyte_apopto0.55591334
128MP0001984_abnormal_olfaction0.54392950
129MP0002127_abnormal_cardiovascular_syste0.53464325
130MP0003075_altered_response_to0.52827176
131MP0009763_increased_sensitivity_to0.52712046

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.97187713
2Systemic lupus erythematosus (HP:0002725)4.75340221
3Hyperglycinuria (HP:0003108)4.74744188
4Ketosis (HP:0001946)4.67981265
5Ketoacidosis (HP:0001993)4.57611488
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.54303812
7Intrahepatic cholestasis (HP:0001406)4.45928023
8Hyperammonemia (HP:0001987)4.34265584
9Abnormality of glycine metabolism (HP:0010895)4.31022548
10Abnormality of serine family amino acid metabolism (HP:0010894)4.31022548
11Xanthomatosis (HP:0000991)4.24419355
12Hyperglycinemia (HP:0002154)4.19413858
13Abnormality of fatty-acid metabolism (HP:0004359)4.16290353
14Hyperlipoproteinemia (HP:0010980)4.11921538
15Deep venous thrombosis (HP:0002625)4.00390590
16Myoglobinuria (HP:0002913)3.96040533
17Abnormality of liposaccharide metabolism (HP:0010968)3.94435438
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.94435438
19Abnormality of glycolipid metabolism (HP:0010969)3.94435438
20Abnormality of complement system (HP:0005339)3.81536487
21Hypoalphalipoproteinemia (HP:0003233)3.68813138
22Exercise-induced myalgia (HP:0003738)3.64021949
23Nemaline bodies (HP:0003798)3.63319199
24Prolonged partial thromboplastin time (HP:0003645)3.62764622
25Muscle fiber inclusion bodies (HP:0100299)3.59780574
26Abnormality of dicarboxylic acid metabolism (HP:0010995)3.59511231
27Dicarboxylic aciduria (HP:0003215)3.59511231
28Abnormality of monocarboxylic acid metabolism (HP:0010996)3.52232199
29Glomerulonephritis (HP:0000099)3.46772404
30Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.45357449
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.31665413
32Hypolipoproteinemia (HP:0010981)3.29550960
33Abnormality of glutamine family amino acid metabolism (HP:0010902)3.24914869
34Sudden death (HP:0001699)3.24675474
35Gout (HP:0001997)3.22662856
36Hypobetalipoproteinemia (HP:0003563)3.21491295
37Generalized aminoaciduria (HP:0002909)3.06945702
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.06150508
39Metabolic acidosis (HP:0001942)3.05285544
40Hyperinsulinemic hypoglycemia (HP:0000825)3.04959822
41Hypoglycemic seizures (HP:0002173)3.03044998
42Exercise-induced muscle cramps (HP:0003710)2.97333640
43Cerebral edema (HP:0002181)2.95367478
44Recurrent gram-negative bacterial infections (HP:0005420)2.87576482
45Abnormality of aspartate family amino acid metabolism (HP:0010899)2.87123153
46Abnormality of serum amino acid levels (HP:0003112)2.85666875
47Abnormality of purine metabolism (HP:0004352)2.82269451
48Complement deficiency (HP:0004431)2.79694631
49Rhabdomyolysis (HP:0003201)2.76987068
50Lethargy (HP:0001254)2.76365854
51Calf muscle hypertrophy (HP:0008981)2.74730196
52Delayed CNS myelination (HP:0002188)2.69276133
53Abnormality of sulfur amino acid metabolism (HP:0004339)2.69173778
54Epidermoid cyst (HP:0200040)2.68203253
55Joint hemorrhage (HP:0005261)2.64596153
56Purpura (HP:0000979)2.63968974
57Type 1 muscle fiber predominance (HP:0003803)2.62974876
58Ventricular tachycardia (HP:0004756)2.61616666
59Right ventricular cardiomyopathy (HP:0011663)2.60072781
60Proximal tubulopathy (HP:0000114)2.58558454
61Muscle hypertrophy of the lower extremities (HP:0008968)2.58172611
62Renal cortical cysts (HP:0000803)2.56917950
63Palpitations (HP:0001962)2.54226598
64Increased purine levels (HP:0004368)2.52665281
65Hyperuricemia (HP:0002149)2.52665281
66Abnormality of methionine metabolism (HP:0010901)2.51235115
67Conjugated hyperbilirubinemia (HP:0002908)2.51092384
68Hepatic necrosis (HP:0002605)2.43043388
69EMG: myopathic abnormalities (HP:0003458)2.41752565
70Vomiting (HP:0002013)2.41578164
71Myocardial infarction (HP:0001658)2.41235647
72Acute encephalopathy (HP:0006846)2.39780345
73Atrioventricular block (HP:0001678)2.38849156
74Hyperbilirubinemia (HP:0002904)2.37443786
75Fat malabsorption (HP:0002630)2.37382068
76Late onset (HP:0003584)2.36768315
77Abnormality of nucleobase metabolism (HP:0010932)2.36006850
78Syncope (HP:0001279)2.35970340
79Abnormality of the common coagulation pathway (HP:0010990)2.34040028
80Vascular calcification (HP:0004934)2.33641304
81Atrial fibrillation (HP:0005110)2.31538033
82Steatorrhea (HP:0002570)2.29114387
83Distal lower limb muscle weakness (HP:0009053)2.28158442
84Abnormality of mucopolysaccharide metabolism (HP:0011020)2.27813585
85Abnormality of polysaccharide metabolism (HP:0011012)2.27813585
86Abnormality of glycosaminoglycan metabolism (HP:0004371)2.27813585
87Muscle fiber splitting (HP:0003555)2.26927032
88Pulmonary embolism (HP:0002204)2.24376198
89Hydroxyprolinuria (HP:0003080)2.23816598
90Abnormality of proline metabolism (HP:0010907)2.23816598
91Nephritis (HP:0000123)2.23698669
92Increased muscle lipid content (HP:0009058)2.22877228
93Heart block (HP:0012722)2.21655972
94Dysostosis multiplex (HP:0000943)2.20098635
95Methylmalonic aciduria (HP:0012120)2.20015017
96Hyporeflexia of lower limbs (HP:0002600)2.17769104
97Asymmetric septal hypertrophy (HP:0001670)2.17704690
98Abnormality of the calf musculature (HP:0001430)2.16314944
99Abnormality of urine glucose concentration (HP:0011016)2.16131680
100Glycosuria (HP:0003076)2.16131680
101Lipoatrophy (HP:0100578)2.15996833
102Abnormality of the intrinsic pathway (HP:0010989)2.15541782
103Mucopolysacchariduria (HP:0008155)2.15292033
104Urinary glycosaminoglycan excretion (HP:0003541)2.15292033
105Dilated cardiomyopathy (HP:0001644)2.15221198
106Symptomatic seizures (HP:0011145)2.12859723
107Hypercholesterolemia (HP:0003124)2.12801220
108Gingival bleeding (HP:0000225)2.11747799
109Skin nodule (HP:0200036)2.10940453
110Increased serum ferritin (HP:0003281)2.10837221
111Amyloidosis (HP:0011034)2.09773969
112Hyperglycemia (HP:0003074)2.09277863
113Primary atrial arrhythmia (HP:0001692)2.08227703
114Vacuolated lymphocytes (HP:0001922)2.07994225
115Enlarged kidneys (HP:0000105)2.07422932
116Cardiovascular calcification (HP:0011915)2.06632139
117Rimmed vacuoles (HP:0003805)2.05840826
118Cholelithiasis (HP:0001081)2.05109098
119Abnormal gallbladder morphology (HP:0012437)2.04012882
120Thrombophlebitis (HP:0004418)2.02471845
121Abnormal atrioventricular conduction (HP:0005150)2.02300787
122Bundle branch block (HP:0011710)2.01081232
123Arterial thrombosis (HP:0004420)1.99353531
124Sensorimotor neuropathy (HP:0007141)1.97490479
125Methylmalonic acidemia (HP:0002912)1.97442322
126Alkalosis (HP:0001948)1.95580495
127Nausea (HP:0002018)1.95442866
128Ventricular arrhythmia (HP:0004308)1.95194625
129Increased serum pyruvate (HP:0003542)1.95085264
130Distal arthrogryposis (HP:0005684)1.94628681
131Neck muscle weakness (HP:0000467)1.94152539
132Increased cerebral lipofuscin (HP:0011813)1.93602486
133Supraventricular tachycardia (HP:0004755)1.93483950
134Lactic acidosis (HP:0003128)1.93214643
135Abnormal mitochondria in muscle tissue (HP:0008316)1.92985099
136Orchitis (HP:0100796)1.90237479
137Spontaneous abortion (HP:0005268)1.90171877
138Retrobulbar optic neuritis (HP:0100654)1.89812735
139Optic neuritis (HP:0100653)1.89812735
140Hemorrhage of the eye (HP:0011885)1.89229650
141Abnormality of iron homeostasis (HP:0011031)1.87738054
142Nuclear cataract (HP:0100018)1.83828565
143Myositis (HP:0100614)1.82435559
144Gangrene (HP:0100758)1.81199714
145Loss of speech (HP:0002371)1.77310856
146Abnormality of the periventricular white matter (HP:0002518)1.75257775
147Esophageal neoplasm (HP:0100751)1.74330720
148Neoplasm of head and neck (HP:0012288)1.74330720
149Reduced antithrombin III activity (HP:0001976)1.73040332

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.07809401
2SIK13.65302530
3INSRR3.31660068
4PHKG23.19480521
5PHKG13.19480521
6LMTK23.11976003
7TBK12.96838498
8TTN2.76563232
9PDK32.74410891
10PDK42.74410891
11OBSCN2.61602386
12PINK12.43806197
13TRIB32.19226302
14EIF2AK32.00572431
15MAP3K141.99739286
16WNK41.92607561
17KIT1.91265529
18IKBKE1.89168744
19TRPM71.75511578
20PDK21.67738708
21TIE11.65289448
22FGFR41.61204910
23MAPK151.59070054
24PKN21.57488496
25ERN11.55922919
26NME21.54402448
27LATS11.53114522
28MYLK1.49525421
29MAP2K41.45285238
30PRKAA21.43019033
31STK38L1.33474703
32MAP3K71.31541886
33PIK3CG1.31017433
34ZAP701.29938613
35BMPR1B1.29288840
36MAPK121.27840734
37PIK3CA1.27124965
38SYK1.25881874
39IRAK41.25387526
40PAK31.22383520
41BMPR21.22293711
42SGK21.20252323
43MUSK1.19451600
44SGK31.19071773
45BLK1.16004603
46CSF1R1.13700624
47IKBKB1.11139425
48MAPKAPK31.09000640
49PRKAA11.08925147
50DMPK1.06628367
51SGK4941.06617513
52SGK2231.06617513
53MATK0.99590957
54CAMK1D0.98949418
55FLT30.98079772
56FGFR30.95730910
57ERBB30.94544716
58EIF2AK20.91070806
59CAMK2G0.87716220
60TAOK30.85613852
61EPHA40.83434560
62ACVR1B0.83162124
63CAMK2D0.82777512
64ERBB40.82665232
65MOS0.81798359
66MAP3K110.81494196
67DAPK20.77507675
68PTK60.76057050
69STK380.76052114
70MST1R0.75451870
71FRK0.74923880
72PRKD10.73973842
73CAMK1G0.73586525
74RIPK40.73418554
75MAPK110.72771387
76NEK10.72692998
77PRKG10.72673167
78WNK30.72242993
79PRKACG0.71030285
80CAMKK20.70921054
81OXSR10.70825345
82IRAK30.70067358
83EPHB10.69648351
84PDPK10.68963045
85SCYL20.67646626
86ADRBK20.67406836
87TEC0.66050210
88TGFBR10.65455649
89PIM20.65196600
90LIMK10.64906509
91TAOK20.63151889
92CAMK40.61748904
93GRK70.59749024
94MAPK70.59561392
95NEK90.59248975
96MAP2K30.58618350
97PRKG20.58246379
98EPHA30.58084380
99ABL10.58029029
100HIPK20.58013515
101JAK10.57730102
102RIPK10.57638836
103IGF1R0.57636850
104STK390.56403714
105MAP2K60.56141957
106MAP3K60.55935143
107LCK0.54211866
108JAK20.53689923
109LYN0.53559075
110IRAK20.53535558
111STK240.53306446
112CAMK2A0.52618225
113MAP2K20.52540841
114PRKCE0.51665347
115PRKCH0.51347636
116PRKD30.50577108
117PRKACA0.49998552
118WNK10.49757423
119MET0.49460415
120MAP3K30.46652171
121PKN10.46576612
122ROCK10.46315576
123TGFBR20.46193100
124IRAK10.45261257
125CDC42BPA0.43652669
126MAP3K50.43634704
127FGFR20.43487044
128ABL20.43212846
129FES0.41436027
130NTRK20.41074713
131MAP3K40.41036164
132PRKCG0.40636184
133MARK30.40280079
134PDK10.39986632
135GSK3A0.39426770
136PRKCZ0.38904043
137PRKCQ0.38608494
138MAPK40.38468972
139FER0.37393216
140LATS20.36894813
141PDGFRA0.36689588
142HCK0.36011172
143TYK20.35710832
144SGK10.34996577
145PRPF4B0.34697304
146PRKACB0.34203155

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid degradation_Homo sapiens_hsa000713.32924251
2Nitrogen metabolism_Homo sapiens_hsa009103.32286559
3Propanoate metabolism_Homo sapiens_hsa006403.17630539
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.09674140
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.09368233
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.09315495
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66698265
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.65326287
9Fatty acid metabolism_Homo sapiens_hsa012122.60433186
10Butanoate metabolism_Homo sapiens_hsa006502.51065284
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.47176402
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.46546459
13Tryptophan metabolism_Homo sapiens_hsa003802.45400231
14Arginine biosynthesis_Homo sapiens_hsa002202.43880908
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.32399160
16PPAR signaling pathway_Homo sapiens_hsa033202.15265799
17* Peroxisome_Homo sapiens_hsa041462.04431472
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99429464
19Pyruvate metabolism_Homo sapiens_hsa006201.89189078
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.77864920
21Asthma_Homo sapiens_hsa053101.77492258
22beta-Alanine metabolism_Homo sapiens_hsa004101.77325620
23Carbon metabolism_Homo sapiens_hsa012001.73247423
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.67600547
25Complement and coagulation cascades_Homo sapiens_hsa046101.64660974
26Fatty acid elongation_Homo sapiens_hsa000621.63270418
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.57306952
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.48562704
29Other glycan degradation_Homo sapiens_hsa005111.47668256
30Starch and sucrose metabolism_Homo sapiens_hsa005001.42030754
31Bile secretion_Homo sapiens_hsa049761.39036151
32Sulfur metabolism_Homo sapiens_hsa009201.36275331
33* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35298948
34Allograft rejection_Homo sapiens_hsa053301.34834104
35Phenylalanine metabolism_Homo sapiens_hsa003601.32623401
36Chemical carcinogenesis_Homo sapiens_hsa052041.31883698
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.31573336
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30890538
39Fatty acid biosynthesis_Homo sapiens_hsa000611.30770817
40Histidine metabolism_Homo sapiens_hsa003401.28991196
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19274676
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17691687
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.17594661
44Caffeine metabolism_Homo sapiens_hsa002321.17045898
45Tyrosine metabolism_Homo sapiens_hsa003501.16153636
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.14138278
47Autoimmune thyroid disease_Homo sapiens_hsa053201.10664638
48Biosynthesis of amino acids_Homo sapiens_hsa012301.10303271
49Retinol metabolism_Homo sapiens_hsa008301.09919859
50Lysosome_Homo sapiens_hsa041421.02326114
51Graft-versus-host disease_Homo sapiens_hsa053321.00340331
52Arginine and proline metabolism_Homo sapiens_hsa003300.99214069
53Selenocompound metabolism_Homo sapiens_hsa004500.97910830
54Pertussis_Homo sapiens_hsa051330.97242175
55Leishmaniasis_Homo sapiens_hsa051400.96719556
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96649989
57Lysine degradation_Homo sapiens_hsa003100.95005034
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.93503134
59Arachidonic acid metabolism_Homo sapiens_hsa005900.92843341
60ABC transporters_Homo sapiens_hsa020100.90819678
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90438923
62Fat digestion and absorption_Homo sapiens_hsa049750.90002756
63Rheumatoid arthritis_Homo sapiens_hsa053230.84627026
64Glycerolipid metabolism_Homo sapiens_hsa005610.84418108
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.82886410
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.82191714
67Staphylococcus aureus infection_Homo sapiens_hsa051500.81010093
68Cardiac muscle contraction_Homo sapiens_hsa042600.79462730
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76938500
70Type I diabetes mellitus_Homo sapiens_hsa049400.76184258
71Oxidative phosphorylation_Homo sapiens_hsa001900.71390202
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70379991
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68059757
74Sulfur relay system_Homo sapiens_hsa041220.65782500
75Insulin resistance_Homo sapiens_hsa049310.65206564
76Vitamin digestion and absorption_Homo sapiens_hsa049770.63778830
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.63586391
78Parkinsons disease_Homo sapiens_hsa050120.61140562
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60973236
80Glucagon signaling pathway_Homo sapiens_hsa049220.60890655
81Sphingolipid metabolism_Homo sapiens_hsa006000.58742475
82African trypanosomiasis_Homo sapiens_hsa051430.58579778
83Tuberculosis_Homo sapiens_hsa051520.58371851
84Folate biosynthesis_Homo sapiens_hsa007900.58347319
85Viral myocarditis_Homo sapiens_hsa054160.57057358
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55972604
87Antigen processing and presentation_Homo sapiens_hsa046120.50042930
88Alzheimers disease_Homo sapiens_hsa050100.49871437
89Metabolic pathways_Homo sapiens_hsa011000.49601934
90Dilated cardiomyopathy_Homo sapiens_hsa054140.47303537
91Fructose and mannose metabolism_Homo sapiens_hsa000510.47011155
92Steroid biosynthesis_Homo sapiens_hsa001000.46052576
93Glutathione metabolism_Homo sapiens_hsa004800.43093090
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42749770
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.42693359
96Hematopoietic cell lineage_Homo sapiens_hsa046400.41962268
97Vitamin B6 metabolism_Homo sapiens_hsa007500.41062711
98Pentose phosphate pathway_Homo sapiens_hsa000300.40111037
99Galactose metabolism_Homo sapiens_hsa000520.39862173
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39620252
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36746652
102Renin-angiotensin system_Homo sapiens_hsa046140.34591304
103AMPK signaling pathway_Homo sapiens_hsa041520.34201337
104Mineral absorption_Homo sapiens_hsa049780.31970762
105Insulin signaling pathway_Homo sapiens_hsa049100.31709903
106Toxoplasmosis_Homo sapiens_hsa051450.31220937
107Osteoclast differentiation_Homo sapiens_hsa043800.30982241
108Phagosome_Homo sapiens_hsa041450.30550816
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29149280
110Huntingtons disease_Homo sapiens_hsa050160.28982319
111Legionellosis_Homo sapiens_hsa051340.28477202
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28150026
113Hepatitis C_Homo sapiens_hsa051600.27865832
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27827034
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27462615
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.24884219
117Circadian rhythm_Homo sapiens_hsa047100.23777609
118Insulin secretion_Homo sapiens_hsa049110.21429728
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.11853231
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.11699841
121Type II diabetes mellitus_Homo sapiens_hsa049300.11393104
122Thyroid hormone synthesis_Homo sapiens_hsa049180.10553576
123Linoleic acid metabolism_Homo sapiens_hsa005910.09538216
124Gastric acid secretion_Homo sapiens_hsa049710.09455090
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.09051610
126Prion diseases_Homo sapiens_hsa050200.08062119
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.07324096
128Pancreatic secretion_Homo sapiens_hsa049720.06367399
129Calcium signaling pathway_Homo sapiens_hsa040200.06055377
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.05435370
131Ovarian steroidogenesis_Homo sapiens_hsa049130.05129952
132Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.05010206

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