DDB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.21187387
2nuclear pore organization (GO:0006999)5.16762334
3DNA unwinding involved in DNA replication (GO:0006268)4.30794470
4regulation of translational fidelity (GO:0006450)4.28693069
5pre-miRNA processing (GO:0031054)4.21154285
6heterochromatin organization (GO:0070828)4.17794003
7regulation of posttranscriptional gene silencing (GO:0060147)4.15391276
8regulation of gene silencing by miRNA (GO:0060964)4.15391276
9regulation of gene silencing by RNA (GO:0060966)4.15391276
10paraxial mesoderm development (GO:0048339)4.14337223
11folic acid-containing compound biosynthetic process (GO:0009396)4.13197725
12retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.01437513
13protein localization to kinetochore (GO:0034501)3.98828782
14mitotic nuclear envelope disassembly (GO:0007077)3.94112027
15proline biosynthetic process (GO:0006561)3.92758645
16regulation of hippo signaling (GO:0035330)3.87386917
17pore complex assembly (GO:0046931)3.80156938
18nuclear envelope disassembly (GO:0051081)3.79087186
19membrane disassembly (GO:0030397)3.79087186
20regulation of translational termination (GO:0006449)3.76239700
21DNA replication-dependent nucleosome organization (GO:0034723)3.61486869
22DNA replication-dependent nucleosome assembly (GO:0006335)3.61486869
23polarized epithelial cell differentiation (GO:0030859)3.51503463
24hippo signaling (GO:0035329)3.50481072
25positive regulation of SMAD protein import into nucleus (GO:0060391)3.49399112
26establishment of apical/basal cell polarity (GO:0035089)3.46358260
27Golgi transport vesicle coating (GO:0048200)3.44134750
28COPI coating of Golgi vesicle (GO:0048205)3.44134750
29maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.42962253
30protein retention in ER lumen (GO:0006621)3.41059462
31regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.39945865
32chromatin assembly (GO:0031497)3.39252513
33sister chromatid segregation (GO:0000819)3.38357247
34regulation of nucleobase-containing compound transport (GO:0032239)3.38273182
35IMP biosynthetic process (GO:0006188)3.35405764
36regulation of mammary gland epithelial cell proliferation (GO:0033599)3.32468841
37protein complex localization (GO:0031503)3.32088112
38spliceosomal tri-snRNP complex assembly (GO:0000244)3.29718992
39peptidyl-lysine dimethylation (GO:0018027)3.27673840
40negative regulation of DNA repair (GO:0045738)3.26015157
41regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.24838759
42negative regulation of histone methylation (GO:0031061)3.24041201
43mitotic chromosome condensation (GO:0007076)3.23521375
44regulation of SMAD protein import into nucleus (GO:0060390)3.23435807
45dosage compensation (GO:0007549)3.22068580
46regulation of mitotic spindle organization (GO:0060236)3.19482278
47cellular protein complex localization (GO:0034629)3.19348550
48DNA duplex unwinding (GO:0032508)3.18125977
49regulation of spindle organization (GO:0090224)3.16129601
50DNA geometric change (GO:0032392)3.15636630
51mitotic sister chromatid cohesion (GO:0007064)3.13377038
52regulation of sister chromatid cohesion (GO:0007063)3.13331881
53DNA replication initiation (GO:0006270)3.12426193
54protein localization to chromosome, centromeric region (GO:0071459)3.11936451
55NLS-bearing protein import into nucleus (GO:0006607)3.11287409
56regulation of RNA export from nucleus (GO:0046831)3.07441529
57mitotic sister chromatid segregation (GO:0000070)3.05194872
58nuclear envelope organization (GO:0006998)3.04161957
59vesicle coating (GO:0006901)3.02254152
60regulation of histone H3-K9 methylation (GO:0051570)3.00470776
61regulation of NFAT protein import into nucleus (GO:0051532)2.97951030
62DNA strand elongation involved in DNA replication (GO:0006271)2.97098334
63nucleosome disassembly (GO:0006337)2.96894457
64protein-DNA complex disassembly (GO:0032986)2.96894457
65protein export from nucleus (GO:0006611)2.96078609
66glucocorticoid receptor signaling pathway (GO:0042921)2.95034866
67DNA strand elongation (GO:0022616)2.92773839
68spindle assembly involved in mitosis (GO:0090307)2.92005629
69establishment of monopolar cell polarity (GO:0061162)2.89256697
70establishment or maintenance of monopolar cell polarity (GO:0061339)2.89256697
71adherens junction assembly (GO:0034333)2.88555527
72positive regulation of chromosome segregation (GO:0051984)2.84316122
73IMP metabolic process (GO:0046040)2.83960783
74epithelial cell-cell adhesion (GO:0090136)2.83301292
75mRNA stabilization (GO:0048255)2.79877556
76RNA stabilization (GO:0043489)2.79877556
77peptidyl-arginine omega-N-methylation (GO:0035247)2.78335337
78chaperone-mediated protein complex assembly (GO:0051131)2.77491215
79gene silencing by RNA (GO:0031047)2.76991458
80regulation of glucose import in response to insulin stimulus (GO:2001273)2.76977803
81histone arginine methylation (GO:0034969)2.70975974
82microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.70159686
83COPII vesicle coating (GO:0048208)2.70045962
84positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.66775310
85positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.66775310
86positive regulation of mitotic sister chromatid separation (GO:1901970)2.66775310
87establishment of integrated proviral latency (GO:0075713)2.66635156
88planar cell polarity pathway involved in neural tube closure (GO:0090179)2.64262751
89nucleobase biosynthetic process (GO:0046112)2.64208446
90anterior/posterior axis specification, embryo (GO:0008595)2.63554065
91DNA topological change (GO:0006265)2.61812228
92pentose-phosphate shunt (GO:0006098)2.59629730
93formation of translation preinitiation complex (GO:0001731)2.58890424
94trophectodermal cell differentiation (GO:0001829)2.58199446
95activation of Rac GTPase activity (GO:0032863)2.57033401
96mitotic G1 DNA damage checkpoint (GO:0031571)2.55562957
97nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.54288803
98protein localization to endosome (GO:0036010)2.54059533
99maternal placenta development (GO:0001893)2.53468122
100regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.52816319
101translesion synthesis (GO:0019985)2.52769942
102convergent extension (GO:0060026)2.52627782
103mitotic metaphase plate congression (GO:0007080)2.52051809
104cellular response to epidermal growth factor stimulus (GO:0071364)2.50810262
105proline metabolic process (GO:0006560)2.50776939
106protein localization to microtubule (GO:0035372)2.49252711
107gene silencing (GO:0016458)2.49172212
108activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.48737663
109peptidyl-arginine methylation (GO:0018216)2.48313837
110peptidyl-arginine N-methylation (GO:0035246)2.48313837
111positive regulation of nuclease activity (GO:0032075)2.47747374
112embryonic foregut morphogenesis (GO:0048617)2.47620087
113mitotic cytokinesis (GO:0000281)2.46685433
114cytoskeletal anchoring at plasma membrane (GO:0007016)2.45773758
115regulation of chromosome segregation (GO:0051983)2.45675814
116negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.45147259
117chromosome condensation (GO:0030261)2.44274993
118regulation of cholesterol homeostasis (GO:2000188)2.43398689
119protein localization to chromosome (GO:0034502)2.43214571
120cell-substrate junction assembly (GO:0007044)2.43147382
121basement membrane organization (GO:0071711)2.42920130
122plasma membrane repair (GO:0001778)2.42838370
123endoplasmic reticulum unfolded protein response (GO:0030968)2.42074864
124ER-nucleus signaling pathway (GO:0006984)2.41845568
125gastrulation with mouth forming second (GO:0001702)2.41779292
126negative regulation of cell size (GO:0045792)2.41372294
127DNA conformation change (GO:0071103)2.41200084
128cell-substrate adherens junction assembly (GO:0007045)2.40070628
129focal adhesion assembly (GO:0048041)2.40070628
130mRNA transport (GO:0051028)2.40034484
131embryonic process involved in female pregnancy (GO:0060136)2.39250864
132chromatin assembly or disassembly (GO:0006333)2.39065586
133positive regulation of hormone biosynthetic process (GO:0046886)2.38201479
134NADPH regeneration (GO:0006740)2.35650826
135regulation of early endosome to late endosome transport (GO:2000641)2.34557190
136notochord development (GO:0030903)2.33318276
137regulation of nuclease activity (GO:0032069)2.32748361
138regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.31647600
139nucleobase-containing small molecule interconversion (GO:0015949)2.30567567
140regulation of cholesterol biosynthetic process (GO:0045540)2.30347049
141peptidyl-proline hydroxylation (GO:0019511)2.30221143
142regulation of chromatin binding (GO:0035561)2.30079815
143response to epidermal growth factor (GO:0070849)2.29820652
144midgut development (GO:0007494)2.29142468

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.40188393
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.88560975
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.47424254
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.02724836
5* MYC_18555785_ChIP-Seq_MESCs_Mouse2.72861709
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.72806490
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.66272876
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.65693049
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.60098523
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.58533154
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.43521882
12* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41760190
13AR_21909140_ChIP-Seq_LNCAP_Human2.35563029
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.31235250
15MYC_22102868_ChIP-Seq_BL_Human2.25024395
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.18264617
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.16133633
18CLOCK_20551151_ChIP-Seq_293T_Human2.11239772
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.00951978
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99692591
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.99601309
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.98244914
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.96768358
24* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91270183
25ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.87320370
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.79314192
27* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73843622
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.70715067
29ZNF263_19887448_ChIP-Seq_K562_Human1.67758380
30SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.62734697
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60217810
32* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.55777176
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55517389
34XRN2_22483619_ChIP-Seq_HELA_Human1.55380474
35TCF3_18692474_ChIP-Seq_MEFs_Mouse1.54993515
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51970483
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51294402
38ATF3_27146783_Chip-Seq_COLON_Human1.50950870
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50930087
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.48915771
41* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48088703
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47051605
43* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45630459
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45267451
45KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44990002
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44615485
47KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44615485
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44615485
49* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.43666717
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43087527
51* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.42812337
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42550296
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42291146
54SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41889488
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40080095
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38782276
57LXR_22292898_ChIP-Seq_THP-1_Human1.38780245
58CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.37608276
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.36964651
60NANOG_21062744_ChIP-ChIP_HESCs_Human1.34756552
61* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34435819
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.32407681
63HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31314123
64* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31229918
65SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.30516206
66* ELK3_25401928_ChIP-Seq_HUVEC_Human1.29452218
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28236327
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27222929
69* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.27214762
70* CHD1_26751641_Chip-Seq_LNCaP_Human1.25790349
71TFEB_21752829_ChIP-Seq_HELA_Human1.25450746
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24413523
73* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23636015
74SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.22956828
75KDM2B_26808549_Chip-Seq_K562_Human1.21512158
76TCF3_18692474_ChIP-Seq_MESCs_Mouse1.21144559
77KDM5A_27292631_Chip-Seq_BREAST_Human1.20263929
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17921863
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16601938
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16586840
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15769412
82KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15171315
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14806963
84NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.13929495
85KDM2B_26808549_Chip-Seq_DND41_Human1.13890383
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13407630
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13137940
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12620540
89* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.12440009
90* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12043474
91TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10755006
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10168493
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09379437
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09239567
95TCF7_22412390_ChIP-Seq_EML_Mouse1.07830293
96CIITA_25753668_ChIP-Seq_RAJI_Human1.07763234
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06067881
98* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05943383
99* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05753206
100* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05435497
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05396033
102NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05372667
103PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04163750
104PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02993388
105DCP1A_22483619_ChIP-Seq_HELA_Human1.02880241
106ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02663245
107TP53_22127205_ChIP-Seq_IMR90_Human1.02516299
108ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01995895
109E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01434386
110KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01275418
111WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00375779
112RACK7_27058665_Chip-Seq_MCF-7_Human1.00216449
113ESR2_21235772_ChIP-Seq_MCF-7_Human0.99426375
114NCOR1_26117541_ChIP-Seq_K562_Human0.99340046
115TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99323317
116TRIM28_21343339_ChIP-Seq_HEK293_Human0.99301172
117VDR_21846776_ChIP-Seq_THP-1_Human0.98717051
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97941090
119TP63_19390658_ChIP-ChIP_HaCaT_Human0.97863848
120ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96739148
121PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96195992
122ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95452234
123BRD4_25478319_ChIP-Seq_HGPS_Human0.94892002
124EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94529298
125UBF1/2_26484160_Chip-Seq_HMECs_Human0.94028124
126FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93912541
127TTF2_22483619_ChIP-Seq_HELA_Human0.93832103

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.39493484
2MP0010352_gastrointestinal_tract_polyps3.46271106
3MP0008438_abnormal_cutaneous_collagen3.24251511
4MP0005076_abnormal_cell_differentiation2.57544243
5MP0010234_abnormal_vibrissa_follicle2.53739209
6MP0000537_abnormal_urethra_morphology2.51938479
7MP0003123_paternal_imprinting2.35606612
8MP0005623_abnormal_meninges_morphology2.27294364
9MP0004957_abnormal_blastocyst_morpholog2.22494663
10MP0003111_abnormal_nucleus_morphology2.22169051
11MP0003566_abnormal_cell_adhesion2.20044726
12MP0010030_abnormal_orbit_morphology2.05299091
13MP0001730_embryonic_growth_arrest2.04140047
14MP0010307_abnormal_tumor_latency2.03079552
15MP0009053_abnormal_anal_canal2.02739455
16MP0005275_abnormal_skin_tensile1.97276065
17MP0003077_abnormal_cell_cycle1.95780625
18MP0004197_abnormal_fetal_growth/weight/1.95453543
19MP0004272_abnormal_basement_membrane1.89488833
20MP0010094_abnormal_chromosome_stability1.85190941
21MP0002084_abnormal_developmental_patter1.84156795
22MP0003693_abnormal_embryo_hatching1.81424297
23MP0000733_abnormal_muscle_development1.79385715
24MP0002877_abnormal_melanocyte_morpholog1.76189923
25MP0006054_spinal_hemorrhage1.74906415
26MP0001661_extended_life_span1.72856901
27MP0005451_abnormal_body_composition1.71794234
28MP0000350_abnormal_cell_proliferation1.69808601
29MP0005380_embryogenesis_phenotype1.68371665
30MP0001672_abnormal_embryogenesis/_devel1.68371665
31MP0001849_ear_inflammation1.64467441
32MP0002086_abnormal_extraembryonic_tissu1.63417334
33MP0002085_abnormal_embryonic_tissue1.61997552
34MP0003283_abnormal_digestive_organ1.61401705
35MP0001697_abnormal_embryo_size1.60179875
36MP0003984_embryonic_growth_retardation1.59383141
37MP0005023_abnormal_wound_healing1.59321233
38MP0002088_abnormal_embryonic_growth/wei1.58656348
39MP0008007_abnormal_cellular_replicative1.54999240
40MP0000566_synostosis1.51453613
41MP0000428_abnormal_craniofacial_morphol1.48977907
42MP0004858_abnormal_nervous_system1.47847072
43MP0003119_abnormal_digestive_system1.44304188
44MP0004233_abnormal_muscle_weight1.42812767
45MP0002653_abnormal_ependyma_morphology1.41666537
46MP0003121_genomic_imprinting1.40237973
47* MP0002080_prenatal_lethality1.37317777
48MP0003091_abnormal_cell_migration1.34518532
49MP0005409_darkened_coat_color1.34491140
50MP0003115_abnormal_respiratory_system1.33595876
51MP0005503_abnormal_tendon_morphology1.33357875
52MP0003567_abnormal_fetal_cardiomyocyte1.32847794
53MP0003890_abnormal_embryonic-extraembry1.29821572
54MP0002089_abnormal_postnatal_growth/wei1.27574265
55MP0003937_abnormal_limbs/digits/tail_de1.26474640
56MP0000747_muscle_weakness1.25470576
57MP0008932_abnormal_embryonic_tissue1.25421626
58MP0002697_abnormal_eye_size1.25172504
59MP0001346_abnormal_lacrimal_gland1.24245693
60MP0003279_aneurysm1.23632088
61MP0004185_abnormal_adipocyte_glucose1.23278112
62MP0003385_abnormal_body_wall1.22120581
63MP0002009_preneoplasia1.19138954
64MP0003329_amyloid_beta_deposits1.18968801
65MP0005501_abnormal_skin_physiology1.16179381
66MP0004264_abnormal_extraembryonic_tissu1.15380987
67MP0000534_abnormal_ureter_morphology1.15261638
68MP0001293_anophthalmia1.14546593
69MP0005058_abnormal_lysosome_morphology1.13970641
70MP0003942_abnormal_urinary_system1.13071070
71MP0002111_abnormal_tail_morphology1.11848126
72MP0003300_gastrointestinal_ulcer1.10839405
73MP0003453_abnormal_keratinocyte_physiol1.10225693
74MP0002796_impaired_skin_barrier1.08918825
75MP0000751_myopathy1.08006837
76MP0002092_abnormal_eye_morphology1.07982886
77MP0003935_abnormal_craniofacial_develop1.07639734
78MP0009672_abnormal_birth_weight1.05458634
79MP0003221_abnormal_cardiomyocyte_apopto1.05220885
80MP0002925_abnormal_cardiovascular_devel1.04857688
81MP0009703_decreased_birth_body1.03536214
82MP0001958_emphysema1.02230221
83MP0000579_abnormal_nail_morphology1.00934456
84MP0000762_abnormal_tongue_morphology1.00626785
85MP0009384_cardiac_valve_regurgitation0.98254019
86MP0002896_abnormal_bone_mineralization0.97897105
87MP0005187_abnormal_penis_morphology0.96038745
88MP0008260_abnormal_autophagy0.95895200
89MP0005248_abnormal_Harderian_gland0.95873593
90MP0008057_abnormal_DNA_replication0.95719165
91* MP0001915_intracranial_hemorrhage0.95619438
92MP0000432_abnormal_head_morphology0.94854727
93MP0002282_abnormal_trachea_morphology0.92577439
94MP0003941_abnormal_skin_development0.90609623
95MP0000013_abnormal_adipose_tissue0.89217714
96MP0002932_abnormal_joint_morphology0.88334937
97MP0003315_abnormal_perineum_morphology0.87822837
98MP0001299_abnormal_eye_distance/0.87346110
99MP0004808_abnormal_hematopoietic_stem0.87178367
100MP0003755_abnormal_palate_morphology0.87037518
101MP0002060_abnormal_skin_morphology0.87008293
102MP0000759_abnormal_skeletal_muscle0.86404758
103MP0005508_abnormal_skeleton_morphology0.86144313
104MP0000003_abnormal_adipose_tissue0.85810882
105MP0004084_abnormal_cardiac_muscle0.84988149
106MP0000750_abnormal_muscle_regeneration0.84196417
107MP0002098_abnormal_vibrissa_morphology0.83780911
108MP0005666_abnormal_adipose_tissue0.83350920
109MP0002234_abnormal_pharynx_morphology0.81794053
110MP0005257_abnormal_intraocular_pressure0.81706961
111MP0009278_abnormal_bone_marrow0.81413096
112* MP0003861_abnormal_nervous_system0.81143837
113MP0005384_cellular_phenotype0.80602816
114MP0010630_abnormal_cardiac_muscle0.79568437
115MP0009697_abnormal_copulation0.79091494
116MP0000377_abnormal_hair_follicle0.78910167
117MP0003122_maternal_imprinting0.78410660
118MP0005375_adipose_tissue_phenotype0.77884581
119MP0000266_abnormal_heart_morphology0.77862068
120MP0005197_abnormal_uvea_morphology0.77761862
121MP0000313_abnormal_cell_death0.77691227
122MP0005171_absent_coat_pigmentation0.76776508
123MP0000569_abnormal_digit_pigmentation0.75187637
124MP0005621_abnormal_cell_physiology0.74803587
125MP0002269_muscular_atrophy0.72259670
126MP0004087_abnormal_muscle_fiber0.72041916
127MP0008770_decreased_survivor_rate0.71626726
128MP0001348_abnormal_lacrimal_gland0.71344907
129MP0004133_heterotaxia0.70887475
130* MP0001614_abnormal_blood_vessel0.70352109
131MP0001286_abnormal_eye_development0.69099616

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.25647813
2Ankle contracture (HP:0006466)3.64458404
3Shallow orbits (HP:0000586)3.47827308
4Premature rupture of membranes (HP:0001788)3.47259244
5Cerebral aneurysm (HP:0004944)3.20849836
6Ependymoma (HP:0002888)3.17712882
7Insomnia (HP:0100785)3.08070519
8Selective tooth agenesis (HP:0001592)3.05486699
9Astrocytoma (HP:0009592)2.91707453
10Abnormality of the astrocytes (HP:0100707)2.91707453
11Asymmetry of the thorax (HP:0001555)2.91241422
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.83332709
13Short 4th metacarpal (HP:0010044)2.83332709
14Cervical subluxation (HP:0003308)2.69207394
15Abnormality of the calcaneus (HP:0008364)2.64196307
16Bowel diverticulosis (HP:0005222)2.55825474
17Deviation of the thumb (HP:0009603)2.54739572
18Missing ribs (HP:0000921)2.51372913
19Flat acetabular roof (HP:0003180)2.50677825
20Upper limb amyotrophy (HP:0009129)2.50355032
21Distal upper limb amyotrophy (HP:0007149)2.50355032
22Bladder diverticulum (HP:0000015)2.50231267
23Ankyloglossia (HP:0010296)2.44708876
24Dysmetric saccades (HP:0000641)2.44524421
25Achilles tendon contracture (HP:0001771)2.43808303
26Hand muscle atrophy (HP:0009130)2.42709887
27Wrist flexion contracture (HP:0001239)2.42281900
28Hyperacusis (HP:0010780)2.41158305
29Increased connective tissue (HP:0009025)2.35561047
30Genu recurvatum (HP:0002816)2.35214609
31Abnormality of the 4th metacarpal (HP:0010012)2.34947104
32Ulnar bowing (HP:0003031)2.32826176
33Renal duplication (HP:0000075)2.29779912
34Mitral valve prolapse (HP:0001634)2.27123536
35Proximal placement of thumb (HP:0009623)2.26929034
36Subacute progressive viral hepatitis (HP:0006572)2.26454144
37Overriding aorta (HP:0002623)2.25938377
38Dilatation of the ascending aorta (HP:0005111)2.23104478
39Aortic aneurysm (HP:0004942)2.21588208
40Radial bowing (HP:0002986)2.20381521
41Colon cancer (HP:0003003)2.19830060
42Termporal pattern (HP:0011008)2.18962006
43Insidious onset (HP:0003587)2.18962006
44Increased density of long bones (HP:0006392)2.17744835
45Metaphyseal cupping (HP:0003021)2.16170328
46Abnormality of the Achilles tendon (HP:0005109)2.15913514
47Distal lower limb amyotrophy (HP:0008944)2.14449912
48Vertebral compression fractures (HP:0002953)2.12742628
49Glioma (HP:0009733)2.12385453
50Abnormality of oral frenula (HP:0000190)2.11012951
51Short nail (HP:0001799)2.09914502
52Vertebral arch anomaly (HP:0008438)2.08900578
53Disproportionate tall stature (HP:0001519)2.08891095
54Difficulty climbing stairs (HP:0003551)2.08732174
55Increased nuchal translucency (HP:0010880)2.06454577
56Aneurysm (HP:0002617)2.05801060
57Broad thumb (HP:0011304)2.05696822
58Aortic dissection (HP:0002647)2.02046679
59Renovascular hypertension (HP:0100817)2.01946688
60Cortical dysplasia (HP:0002539)2.00987503
61Gastrointestinal carcinoma (HP:0002672)2.00740843
62Malignant gastrointestinal tract tumors (HP:0006749)2.00740843
63Back pain (HP:0003418)2.00328535
64Short humerus (HP:0005792)1.99899272
65Heterotopia (HP:0002282)1.99574481
66Atrophic scars (HP:0001075)1.99501844
67Spastic diplegia (HP:0001264)1.98553300
68Biliary tract neoplasm (HP:0100574)1.95241247
69Overlapping toe (HP:0001845)1.93515725
70Deviation of the hallux (HP:0010051)1.93291444
71Reticulocytosis (HP:0001923)1.93102190
72Enlarged penis (HP:0000040)1.92207647
73High anterior hairline (HP:0009890)1.91688413
74Abnormality of the lower motor neuron (HP:0002366)1.91608875
75Advanced eruption of teeth (HP:0006288)1.89589070
76Abnormality of dentin (HP:0010299)1.89285157
77Patellar dislocation (HP:0002999)1.87981495
78Hallux valgus (HP:0001822)1.86642564
79Aplasia involving bones of the extremities (HP:0009825)1.86144007
80Aplasia involving bones of the upper limbs (HP:0009823)1.86144007
81Aplasia of the phalanges of the hand (HP:0009802)1.86144007
82Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.85461978
83Fibroma (HP:0010614)1.85316400
84Soft skin (HP:0000977)1.84387026
85Pseudobulbar signs (HP:0002200)1.83767417
86Hammertoe (HP:0001765)1.83740766
87Relative macrocephaly (HP:0004482)1.83370200
88Spinal cord lesions (HP:0100561)1.83276516
89Syringomyelia (HP:0003396)1.83276516
90Aplasia/hypoplasia of the humerus (HP:0006507)1.82263825
91Arnold-Chiari malformation (HP:0002308)1.81949382
92Rectal prolapse (HP:0002035)1.81277810
93Breech presentation (HP:0001623)1.80631912
94Scapular winging (HP:0003691)1.80609127
95High pitched voice (HP:0001620)1.80390135
96Wormian bones (HP:0002645)1.80055826
97Flat cornea (HP:0007720)1.79975800
98Arterial tortuosity (HP:0005116)1.79873469
99Trismus (HP:0000211)1.79619585
100Medulloblastoma (HP:0002885)1.79395522
101Fibrous tissue neoplasm (HP:0012316)1.79366352
102Deep philtrum (HP:0002002)1.79146632
103Centrally nucleated skeletal muscle fibers (HP:0003687)1.79086646
104Pelvic girdle muscle weakness (HP:0003749)1.78903562
105Lower limb amyotrophy (HP:0007210)1.78589634
106Broad phalanges of the hand (HP:0009768)1.78131973
107Lymphangioma (HP:0100764)1.77991391
108Long palpebral fissure (HP:0000637)1.77720162
109Spinal rigidity (HP:0003306)1.76788187
110Chromosomal breakage induced by crosslinking agents (HP:0003221)1.75942558
111Type 1 muscle fiber predominance (HP:0003803)1.75415167
112Natal tooth (HP:0000695)1.74007571
113Bowing of the arm (HP:0006488)1.73758540
114Bowed forearm bones (HP:0003956)1.73758540
115Abnormal gallbladder physiology (HP:0012438)1.73573967
116Cholecystitis (HP:0001082)1.73573967
117Broad long bones (HP:0005622)1.73253591
118Blue sclerae (HP:0000592)1.72418146
119Vertebral clefting (HP:0008428)1.71034560
120Cutaneous melanoma (HP:0012056)1.70321989
121Osteolytic defects of the hand bones (HP:0009699)1.69707354
122Osteolytic defects of the phalanges of the hand (HP:0009771)1.69707354
123Neoplasm of the oral cavity (HP:0100649)1.69430339
124Elfin facies (HP:0004428)1.69283603
125Angiofibromas (HP:0010615)1.66782534
126Adenoma sebaceum (HP:0009720)1.66782534
127Abnormal ossification of hand bones (HP:0005921)1.66647515
128Mesomelia (HP:0003027)1.66401409
129Hypopigmentation of the fundus (HP:0007894)1.65444398
130Abnormality of pain sensation (HP:0010832)1.65412786
131Impaired pain sensation (HP:0007328)1.65412786
132Abnormality of the acetabulum (HP:0003170)1.65396996
133Vascular tortuosity (HP:0004948)1.64978029
134Broad phalanx (HP:0006009)1.64812675
135Broad face (HP:0000283)1.64152746
136Peritonitis (HP:0002586)1.63578886
137Broad finger (HP:0001500)1.63528213
138Camptodactyly of toe (HP:0001836)1.63514904
139Tibial bowing (HP:0002982)1.63151467
140Rhizomelia (HP:0008905)1.62811291
141Abnormality of the distal phalanges of the toes (HP:0010182)1.62621238
142Limb-girdle muscle weakness (HP:0003325)1.61217254
143Thin ribs (HP:0000883)1.61046234
144Turricephaly (HP:0000262)1.60829345
145Biconcave vertebral bodies (HP:0004586)1.60781340
146Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.60649369
147Shoulder girdle muscle weakness (HP:0003547)1.60219007
148Abnormality of the peritoneum (HP:0002585)1.60063852
149Broad distal phalanx of finger (HP:0009836)1.59712847
150Abnormality of the distal phalanx of the thumb (HP:0009617)1.59575883
151Skull defect (HP:0001362)1.59532933
152Pointed chin (HP:0000307)1.59231348
153Exostoses (HP:0100777)1.59062738
154Buphthalmos (HP:0000557)1.58366363
155Broad palm (HP:0001169)1.58292414
156Midface retrusion (HP:0011800)1.58280388
157Mildly elevated creatine phosphokinase (HP:0008180)1.58199190
158Fragile skin (HP:0001030)1.56183947
159Progressive muscle weakness (HP:0003323)1.55954601
160Chromsome breakage (HP:0040012)1.55762851
161Leiomyosarcoma (HP:0100243)1.55568878
162Uterine leiomyosarcoma (HP:0002891)1.55568878
163Abnormality of the salivary glands (HP:0010286)1.55061948
164Elbow flexion contracture (HP:0002987)1.54756822
165Limited elbow extension (HP:0001377)1.54418436
166Abnormality of carpal bone ossification (HP:0006257)1.54159135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.72467465
2TRIB33.57054085
3SMG13.49238121
4PKN23.48933304
5CDK123.10728486
6TTN2.82573800
7LATS12.58782425
8CDC72.49704973
9EPHA22.44827504
10NEK12.35139174
11SCYL22.17107941
12PDGFRA2.16647447
13MAP3K102.09450147
14NEK22.00043549
15RPS6KB21.91242561
16PASK1.84164144
17LATS21.83329598
18PTK61.79526746
19DDR21.78803698
20PRPF4B1.77369694
21NTRK11.60733024
22PAK41.60266549
23TTK1.56426666
24RIPK11.53590304
25PBK1.47246756
26IRAK31.45663278
27MTOR1.44464922
28WEE11.43424863
29LRRK21.34557968
30TSSK61.33494102
31PAK21.33441722
32MAP3K81.32987858
33MST1R1.31512403
34ALK1.25754050
35TGFBR11.24156020
36SIK11.22567206
37STK101.21567110
38BMX1.21448596
39STK31.20580646
40TESK11.20318036
41NME21.18481834
42CDK61.18130125
43ICK1.16730838
44MET1.16481185
45FGFR11.14999405
46PTK21.14322127
47BRD41.12496835
48FLT31.11971589
49BUB11.06587327
50EIF2AK11.05439687
51CDK41.03591689
52TESK20.99577440
53PRKD30.97800872
54AURKB0.93358632
55CHEK10.92961338
56FER0.92712871
57PLK10.92430991
58CDK70.91975792
59LMTK20.89624701
60RPS6KA40.88394778
61STK38L0.87916181
62CAMK1D0.87616185
63ATR0.87477915
64PLK30.81765471
65MAP2K70.80771338
66PDK30.79407405
67PDK40.79407405
68PDGFRB0.76082068
69TYRO30.71032849
70MAP3K90.70675606
71BRAF0.68808762
72CDK80.67089238
73MAPK110.65676726
74CHEK20.63813936
75MAPKAPK30.63642864
76ERN10.63620784
77CDK20.63184879
78RET0.62978135
79CLK10.61610659
80BRSK20.61354523
81LIMK10.61252354
82ATM0.60766650
83BRSK10.60719594
84KSR20.59536392
85ILK0.58374492
86EPHB20.57886805
87MELK0.57010003
88KSR10.56836242
89ERBB40.55847194
90AKT20.55837013
91CDK150.53317309
92RAF10.53264249
93PAK10.53263687
94RPS6KB10.53173769
95CDK11A0.51631589
96PAK30.50786851
97FGFR30.49390913
98CDK180.48431872
99CSNK1D0.48369612
100RPS6KA20.47590208
101ARAF0.46983644
102CDK10.46469845
103MAP2K30.46111663
104CSNK1E0.45873393
105PRKCI0.45273864
106NEK60.45240207
107AURKA0.43192097
108STK40.41716540
109PRKDC0.41381771
110DYRK1B0.41226153
111MAP2K20.41033874
112MKNK10.40954111
113FRK0.39840396
114CAMK1G0.39512993
115TAOK20.39452449
116PAK60.38740861
117MAP3K30.38540932
118CDK140.38468691
119MAP3K40.38197124
120PDPK10.37884611
121FGFR20.37740552
122MAP3K60.37358955
123CDK90.37301726
124EPHB10.37034616
125ERBB20.37019767
126MAPK100.36523805
127SRPK10.36193079
128MAP2K10.35835583
129MAP2K40.35319357
130ACVR1B0.34923120
131TRPM70.34091206
132FGFR40.33814326
133NEK90.33467599
134PRKAA10.32583889
135PIM10.31217259
136PDK20.30750860

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006702.72666480
2RNA transport_Homo sapiens_hsa030132.57017764
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.49634490
4Cell cycle_Homo sapiens_hsa041102.27895877
5DNA replication_Homo sapiens_hsa030302.16024712
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.00129763
7Adherens junction_Homo sapiens_hsa045201.94942995
8Hippo signaling pathway_Homo sapiens_hsa043901.93672676
9Mismatch repair_Homo sapiens_hsa034301.90028148
10ECM-receptor interaction_Homo sapiens_hsa045121.82086532
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81956382
12Small cell lung cancer_Homo sapiens_hsa052221.81874752
13Spliceosome_Homo sapiens_hsa030401.79857975
14MicroRNAs in cancer_Homo sapiens_hsa052061.78836782
15Focal adhesion_Homo sapiens_hsa045101.74421476
16mRNA surveillance pathway_Homo sapiens_hsa030151.74157486
17Bladder cancer_Homo sapiens_hsa052191.73974315
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.73068335
19Proteoglycans in cancer_Homo sapiens_hsa052051.70602430
20Chronic myeloid leukemia_Homo sapiens_hsa052201.63225738
21Central carbon metabolism in cancer_Homo sapiens_hsa052301.62944112
22p53 signaling pathway_Homo sapiens_hsa041151.59465552
23Basal cell carcinoma_Homo sapiens_hsa052171.59102703
24mTOR signaling pathway_Homo sapiens_hsa041501.56938989
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.53455487
26Systemic lupus erythematosus_Homo sapiens_hsa053221.52551814
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.51902912
28* Viral carcinogenesis_Homo sapiens_hsa052031.48708891
29Biosynthesis of amino acids_Homo sapiens_hsa012301.40896651
30* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.40775763
31Selenocompound metabolism_Homo sapiens_hsa004501.38765308
32Tight junction_Homo sapiens_hsa045301.37592485
33TGF-beta signaling pathway_Homo sapiens_hsa043501.32672653
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.32120953
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30606453
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30123358
37Lysine degradation_Homo sapiens_hsa003101.24672831
38Endometrial cancer_Homo sapiens_hsa052131.24128414
39Fructose and mannose metabolism_Homo sapiens_hsa000511.19433609
40Hedgehog signaling pathway_Homo sapiens_hsa043401.18790073
41Colorectal cancer_Homo sapiens_hsa052101.18107229
42HTLV-I infection_Homo sapiens_hsa051661.17981713
43Thyroid cancer_Homo sapiens_hsa052161.16627329
44Vitamin B6 metabolism_Homo sapiens_hsa007501.14986327
45ErbB signaling pathway_Homo sapiens_hsa040121.13507814
46Base excision repair_Homo sapiens_hsa034101.09816495
47Steroid biosynthesis_Homo sapiens_hsa001001.06602143
48Oocyte meiosis_Homo sapiens_hsa041141.04655073
49Prion diseases_Homo sapiens_hsa050201.04239254
50Notch signaling pathway_Homo sapiens_hsa043301.03666278
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02113172
52Galactose metabolism_Homo sapiens_hsa000521.00411920
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00124648
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98937416
55Other glycan degradation_Homo sapiens_hsa005110.98409539
56Amoebiasis_Homo sapiens_hsa051460.97669053
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96810427
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96254817
59Prostate cancer_Homo sapiens_hsa052150.96028466
60Viral myocarditis_Homo sapiens_hsa054160.94062562
61Non-small cell lung cancer_Homo sapiens_hsa052230.93131989
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92501333
63Glioma_Homo sapiens_hsa052140.90780557
64Pancreatic cancer_Homo sapiens_hsa052120.89523191
65Arginine biosynthesis_Homo sapiens_hsa002200.89443780
66Carbon metabolism_Homo sapiens_hsa012000.88376114
67HIF-1 signaling pathway_Homo sapiens_hsa040660.87223808
68Melanoma_Homo sapiens_hsa052180.87048548
69AMPK signaling pathway_Homo sapiens_hsa041520.86503703
70Pathways in cancer_Homo sapiens_hsa052000.86259336
71* Nucleotide excision repair_Homo sapiens_hsa034200.84201217
72Nitrogen metabolism_Homo sapiens_hsa009100.83304231
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82553627
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.80859892
75Prolactin signaling pathway_Homo sapiens_hsa049170.80395240
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80088186
77Renal cell carcinoma_Homo sapiens_hsa052110.79464517
78Pyruvate metabolism_Homo sapiens_hsa006200.79418981
79Inositol phosphate metabolism_Homo sapiens_hsa005620.78939967
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76851162
81Alcoholism_Homo sapiens_hsa050340.75994111
82RNA degradation_Homo sapiens_hsa030180.75862856
83Vibrio cholerae infection_Homo sapiens_hsa051100.74476388
84Antigen processing and presentation_Homo sapiens_hsa046120.71268883
85Insulin resistance_Homo sapiens_hsa049310.71052955
86Sulfur relay system_Homo sapiens_hsa041220.70229238
87Protein digestion and absorption_Homo sapiens_hsa049740.69873920
88Wnt signaling pathway_Homo sapiens_hsa043100.69164929
89Insulin signaling pathway_Homo sapiens_hsa049100.66646214
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66421417
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.63741745
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62833712
93Epstein-Barr virus infection_Homo sapiens_hsa051690.62672549
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62477738
95Glucagon signaling pathway_Homo sapiens_hsa049220.62472810
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61058846
97Apoptosis_Homo sapiens_hsa042100.61011856
98Choline metabolism in cancer_Homo sapiens_hsa052310.60853996
99Estrogen signaling pathway_Homo sapiens_hsa049150.59479065
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58235368
101N-Glycan biosynthesis_Homo sapiens_hsa005100.58228423
102Fatty acid biosynthesis_Homo sapiens_hsa000610.57566243
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56978914
104FoxO signaling pathway_Homo sapiens_hsa040680.56816226
105VEGF signaling pathway_Homo sapiens_hsa043700.56167748
106Pentose phosphate pathway_Homo sapiens_hsa000300.55092046
107Melanogenesis_Homo sapiens_hsa049160.54799592
108Thyroid hormone synthesis_Homo sapiens_hsa049180.54772108
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53310053
110Fanconi anemia pathway_Homo sapiens_hsa034600.52568746
111Non-homologous end-joining_Homo sapiens_hsa034500.52315771
112Dilated cardiomyopathy_Homo sapiens_hsa054140.52257243
113Gap junction_Homo sapiens_hsa045400.51246292
114Axon guidance_Homo sapiens_hsa043600.50934968
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50782609
116Acute myeloid leukemia_Homo sapiens_hsa052210.50379654
117Homologous recombination_Homo sapiens_hsa034400.49637337
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49364458
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48891537
120Rap1 signaling pathway_Homo sapiens_hsa040150.48139642
121Shigellosis_Homo sapiens_hsa051310.48114273
122Toxoplasmosis_Homo sapiens_hsa051450.45959288
123Cysteine and methionine metabolism_Homo sapiens_hsa002700.45953717
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45449641
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.44128912

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