DCXR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)7.22032869
2sulfur amino acid catabolic process (GO:0000098)6.79446706
3proline metabolic process (GO:0006560)6.60840926
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.97673052
5L-phenylalanine metabolic process (GO:0006558)5.97673052
6epoxygenase P450 pathway (GO:0019373)5.74191421
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.65805650
8L-phenylalanine catabolic process (GO:0006559)5.65805650
9glyoxylate metabolic process (GO:0046487)5.52387689
10exogenous drug catabolic process (GO:0042738)5.52382036
11omega-hydroxylase P450 pathway (GO:0097267)5.44262773
12aromatic amino acid family catabolic process (GO:0009074)5.13629059
13cysteine metabolic process (GO:0006534)4.99317896
14glutamine family amino acid biosynthetic process (GO:0009084)4.80195585
15negative regulation of fatty acid biosynthetic process (GO:0045717)4.68916645
16tryptophan catabolic process (GO:0006569)4.66573239
17indole-containing compound catabolic process (GO:0042436)4.66573239
18indolalkylamine catabolic process (GO:0046218)4.66573239
19serine family amino acid catabolic process (GO:0009071)4.61053824
20kynurenine metabolic process (GO:0070189)4.51340665
21embryonic process involved in female pregnancy (GO:0060136)4.48878234
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.47242473
23transcription from mitochondrial promoter (GO:0006390)4.41890679
24tryptophan metabolic process (GO:0006568)4.33594813
25bile acid biosynthetic process (GO:0006699)4.31574917
26very-low-density lipoprotein particle assembly (GO:0034379)4.27377584
27alkaloid metabolic process (GO:0009820)4.25398878
28drug metabolic process (GO:0017144)4.24825222
29L-serine metabolic process (GO:0006563)4.24298529
30oxaloacetate metabolic process (GO:0006107)4.23711450
31blood coagulation, intrinsic pathway (GO:0007597)4.20218468
32urea cycle (GO:0000050)4.16800095
33urea metabolic process (GO:0019627)4.16800095
34cellular glucuronidation (GO:0052695)4.14569941
35bile acid metabolic process (GO:0008206)4.10028842
36positive regulation of protein homooligomerization (GO:0032464)4.09662215
37response to nitrosative stress (GO:0051409)4.03667463
38oxidative demethylation (GO:0070989)4.03621109
39regulation of cholesterol homeostasis (GO:2000188)4.02868742
40triglyceride homeostasis (GO:0070328)4.02642498
41acylglycerol homeostasis (GO:0055090)4.02642498
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.01523804
43fibrinolysis (GO:0042730)3.98314077
44homocysteine metabolic process (GO:0050667)3.97248274
45nitrogen cycle metabolic process (GO:0071941)3.96134419
46high-density lipoprotein particle remodeling (GO:0034375)3.95525473
47ethanol metabolic process (GO:0006067)3.92579277
48negative regulation of fibrinolysis (GO:0051918)3.92424081
49alpha-linolenic acid metabolic process (GO:0036109)3.90922700
50oxidative phosphorylation (GO:0006119)3.87531587
51peptidyl-glutamic acid carboxylation (GO:0017187)3.87469906
52protein carboxylation (GO:0018214)3.87469906
53uronic acid metabolic process (GO:0006063)3.85961716
54glucuronate metabolic process (GO:0019585)3.85961716
55deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.85626817
56L-ascorbic acid metabolic process (GO:0019852)3.81764641
57aromatic amino acid family metabolic process (GO:0009072)3.81238821
58heme transport (GO:0015886)3.80026423
59serine family amino acid metabolic process (GO:0009069)3.78866442
60regulation of protein homooligomerization (GO:0032462)3.77909569
61amino-acid betaine metabolic process (GO:0006577)3.77680631
62intestinal cholesterol absorption (GO:0030299)3.77079875
63regulation of plasminogen activation (GO:0010755)3.75160034
64lysine catabolic process (GO:0006554)3.71915449
65lysine metabolic process (GO:0006553)3.71915449
66positive regulation of triglyceride lipase activity (GO:0061365)3.71840874
67positive regulation of lipoprotein lipase activity (GO:0051006)3.71840874
68cellular amino acid catabolic process (GO:0009063)3.70922020
69alpha-amino acid catabolic process (GO:1901606)3.70897719
70cholesterol efflux (GO:0033344)3.69710119
71mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.67461160
72negative regulation of cholesterol transport (GO:0032375)3.59722847
73negative regulation of sterol transport (GO:0032372)3.59722847
74phenylpropanoid metabolic process (GO:0009698)3.59119026
75regulation of fibrinolysis (GO:0051917)3.58402024
76complement activation, alternative pathway (GO:0006957)3.57743927
77aldehyde catabolic process (GO:0046185)3.54552331
78regulation of cholesterol esterification (GO:0010872)3.54020555
79plasma lipoprotein particle assembly (GO:0034377)3.52429566
80glycine metabolic process (GO:0006544)3.52396702
81establishment of apical/basal cell polarity (GO:0035089)3.52042983
82ethanol oxidation (GO:0006069)3.50272472
83benzene-containing compound metabolic process (GO:0042537)3.50072764
84regulation of protein activation cascade (GO:2000257)3.49641189
85NADH metabolic process (GO:0006734)3.49255854
86cellular ketone body metabolic process (GO:0046950)3.48528100
87xenobiotic catabolic process (GO:0042178)3.48045876
88acetyl-CoA metabolic process (GO:0006084)3.46645082
89cytolysis (GO:0019835)3.46640732
90imidazole-containing compound metabolic process (GO:0052803)3.45779403
91drug catabolic process (GO:0042737)3.45113184
92negative regulation of fatty acid metabolic process (GO:0045922)3.43420133
93reverse cholesterol transport (GO:0043691)3.42206009
94regulation of integrin activation (GO:0033623)3.40764429
95S-adenosylmethionine metabolic process (GO:0046500)3.38916991
96NAD biosynthetic process (GO:0009435)3.38906514
97fatty acid beta-oxidation (GO:0006635)3.38886469
98cellular modified amino acid catabolic process (GO:0042219)3.36980893
99ATP synthesis coupled proton transport (GO:0015986)3.35494787
100energy coupled proton transport, down electrochemical gradient (GO:0015985)3.35494787
101serine family amino acid biosynthetic process (GO:0009070)3.35157010
102nicotinamide nucleotide biosynthetic process (GO:0019359)3.33875381
103pyridine nucleotide biosynthetic process (GO:0019363)3.33875381
104glutamate metabolic process (GO:0006536)3.33207562
105carboxylic acid catabolic process (GO:0046395)3.32612980
106organic acid catabolic process (GO:0016054)3.32612980
107regulation of triglyceride catabolic process (GO:0010896)3.31187586
108flavonoid metabolic process (GO:0009812)3.29674826
109plasma lipoprotein particle remodeling (GO:0034369)3.28611668
110protein-lipid complex remodeling (GO:0034368)3.28611668
111macromolecular complex remodeling (GO:0034367)3.28611668
112regulation of complement activation (GO:0030449)3.27240860
113cholesterol homeostasis (GO:0042632)3.27164631
114urate metabolic process (GO:0046415)3.25167471
115tyrosine metabolic process (GO:0006570)3.23881370
116DNA deamination (GO:0045006)3.23697847
117cellular biogenic amine catabolic process (GO:0042402)3.23047836
118amine catabolic process (GO:0009310)3.23047836
119sterol homeostasis (GO:0055092)3.22764412
120positive regulation of cellular amine metabolic process (GO:0033240)3.21234684
121plasma lipoprotein particle clearance (GO:0034381)3.20986509
122fatty acid oxidation (GO:0019395)3.20305114
123phospholipid efflux (GO:0033700)3.20268152
124cofactor catabolic process (GO:0051187)3.19009788
125GDP-mannose metabolic process (GO:0019673)3.10706940
126gluconeogenesis (GO:0006094)3.10337008
127disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.07305374
128killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.07305374
129regulation of mitochondrial translation (GO:0070129)3.06850788
130protein activation cascade (GO:0072376)3.04876484
131arginine metabolic process (GO:0006525)3.04454429
132monosaccharide biosynthetic process (GO:0046364)3.02554869
133hexose biosynthetic process (GO:0019319)3.01694460
134respiratory electron transport chain (GO:0022904)2.97746823
135acute-phase response (GO:0006953)2.97298205
136branched-chain amino acid catabolic process (GO:0009083)2.96852903
137monocarboxylic acid catabolic process (GO:0072329)2.95774437
138creatine metabolic process (GO:0006600)2.95081868
139fructose metabolic process (GO:0006000)2.92980279
140opsonization (GO:0008228)2.92899670
141electron transport chain (GO:0022900)2.89756565
142complement activation (GO:0006956)2.89619337
143ketone body metabolic process (GO:1902224)2.87974820
144mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.87501430
145branched-chain amino acid metabolic process (GO:0009081)2.85123477

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.90774459
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.66524795
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.89124158
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.14049908
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.64423899
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.57910410
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.53643342
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.34069349
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84950629
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.83796500
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.78633874
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.77307745
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.66887302
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.55978788
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.51816882
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.21213081
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.20271298
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.20271298
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.20271298
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.14804575
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.11799959
22XRN2_22483619_ChIP-Seq_HELA_Human2.08477947
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.01530821
24SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.97972134
25STAT3_1855785_ChIP-Seq_MESCs_Mouse1.94231634
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.92033283
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.89765496
28NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.89064029
29LXR_22292898_ChIP-Seq_THP-1_Human1.85343125
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.85071683
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.82184663
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.80503987
33* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.75119411
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71943639
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71842713
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.71407546
37GABP_19822575_ChIP-Seq_HepG2_Human1.69011535
38SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.68970782
39NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.66994453
40DCP1A_22483619_ChIP-Seq_HELA_Human1.66603210
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.64958868
42* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.63809971
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62264708
44RXRA_24833708_ChIP-Seq_LIVER_Mouse1.59004325
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58271947
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57753439
47TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.57637964
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.57246168
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.56683994
50RACK7_27058665_Chip-Seq_MCF-7_Human1.55324014
51ZNF263_19887448_ChIP-Seq_K562_Human1.53851932
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.53678656
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.52749225
54TCF3_18692474_ChIP-Seq_MEFs_Mouse1.52378086
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50722823
56VDR_21846776_ChIP-Seq_THP-1_Human1.50542735
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50198231
58CDX2_20551321_ChIP-Seq_CACO-2_Human1.50058693
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48339276
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.47517259
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46297955
62* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46174317
63ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45975596
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.43870735
65POU5F1_16518401_ChIP-PET_MESCs_Mouse1.43801438
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.43732263
67P68_20966046_ChIP-Seq_HELA_Human1.43374399
68EST1_17652178_ChIP-ChIP_JURKAT_Human1.43310232
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.42754173
70CTCF_18555785_ChIP-Seq_MESCs_Mouse1.39062453
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31888620
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.31639383
73TCF3_18692474_ChIP-Seq_MESCs_Mouse1.30737145
74* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30151428
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.29508244
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.25973849
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25152173
78* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24029133
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23651536
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.23111130
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22970815
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22487904
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21391654
84SOX2_18692474_ChIP-Seq_MEFs_Mouse1.20582739
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20563096
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19693418
87TRIM28_21343339_ChIP-Seq_HEK293_Human1.19536513
88CTCF_26484167_Chip-Seq_Bcells_Mouse1.19421819
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19148450
90ESR2_21235772_ChIP-Seq_MCF-7_Human1.18883339
91RARB_24833708_ChIP-Seq_LIVER_Mouse1.18861582
92CLOCK_20551151_ChIP-Seq_293T_Human1.18193391
93* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18078096
94KDM5A_27292631_Chip-Seq_BREAST_Human1.17776336
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16967402
96* FOXP1_21924763_ChIP-Seq_HESCs_Human1.16955114
97RARA_24833708_ChIP-Seq_LIVER_Mouse1.16659503
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16414599
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15438355
100TTF2_22483619_ChIP-Seq_HELA_Human1.14864304
101* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14761429
102E2F7_22180533_ChIP-Seq_HELA_Human1.13545931
103CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12553161
104OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10489618
105TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06521322
106SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05972182
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05549663
108MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05539467
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04979592
110E2F1_20622854_ChIP-Seq_HELA_Human1.03745865
111FOXP3_21729870_ChIP-Seq_TREG_Human1.03509709
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01889012
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00824659
114PHF8_20622854_ChIP-Seq_HELA_Human1.00818759
115SMC4_20622854_ChIP-Seq_HELA_Human1.00323547
116SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99999193
117YY1_22570637_ChIP-Seq_MALME-3M_Human0.99639534
118MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99516018
119* CTCF_21964334_Chip-Seq_Bcells_Human0.99320179
120CTCF_20526341_ChIP-Seq_ESCs_Human0.98960629
121POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98840516
122ELK3_25401928_ChIP-Seq_HUVEC_Human0.98724792
123CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97036010
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96907184
125IRF8_22096565_ChIP-ChIP_GC-B_Human0.96706636
126BCOR_27268052_Chip-Seq_Bcells_Human0.96369737
127POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.95351725
128NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94094859
129ETS1_21867929_ChIP-Seq_TH2_Mouse0.92304813
130ESR1_21235772_ChIP-Seq_MCF-7_Human0.92248720
131KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91789635
132E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90693057
133SOX2_18692474_ChIP-Seq_MESCs_Mouse0.90676592
134TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90487294
135NANOG_18692474_ChIP-Seq_MEFs_Mouse0.89870019
136* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89386634
137GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89347146
138ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88543367
139MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88177667
140KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87946383
141SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87154399
142SPI1_26923725_Chip-Seq_HPCs_Mouse0.86931564
143MYC_18555785_ChIP-Seq_MESCs_Mouse0.86910852
144GATA6_25053715_ChIP-Seq_YYC3_Human0.86810768
145KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86334255
146* HNF4A_19822575_ChIP-Seq_HepG2_Human0.86059472
147SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85829276
148BCL6_27268052_Chip-Seq_Bcells_Human0.85608128
149NANOG_18692474_ChIP-Seq_MESCs_Mouse0.85131841
150NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85102241
151BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83863461
152ATF3_27146783_Chip-Seq_COLON_Human0.83124261
153NANOG_21062744_ChIP-ChIP_HESCs_Human0.81639350
154POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.80327262
155PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78974117
156NANOG_18555785_ChIP-Seq_MESCs_Mouse0.78893948
157SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78149745
158CTCF_27219007_Chip-Seq_ERYTHROID_Human0.78044828

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.15565238
2MP0005360_urolithiasis5.91836086
3MP0005085_abnormal_gallbladder_physiolo5.51767812
4MP0005365_abnormal_bile_salt5.23478396
5MP0008875_abnormal_xenobiotic_pharmacok4.25120519
6MP0003806_abnormal_nucleotide_metabolis3.82163231
7MP0009840_abnormal_foam_cell2.79920340
8MP0003252_abnormal_bile_duct2.72756842
9MP0005332_abnormal_amino_acid2.62369698
10MP0004019_abnormal_vitamin_homeostasis2.52905064
11MP0010329_abnormal_lipoprotein_level2.52157540
12MP0005083_abnormal_biliary_tract2.40354508
13MP0003191_abnormal_cellular_cholesterol2.21570247
14MP0009697_abnormal_copulation2.20108321
15MP0001666_abnormal_nutrient_absorption2.14731238
16MP0010030_abnormal_orbit_morphology2.10813193
17MP0002822_catalepsy2.08761930
18MP0009278_abnormal_bone_marrow2.01200440
19MP0002234_abnormal_pharynx_morphology1.97776531
20MP0003195_calcinosis1.91738361
21MP0001661_extended_life_span1.90650343
22MP0000609_abnormal_liver_physiology1.79266038
23MP0000678_abnormal_parathyroid_gland1.77954978
24MP0003186_abnormal_redox_activity1.77801514
25MP0005058_abnormal_lysosome_morphology1.72741622
26MP0005319_abnormal_enzyme/_coenzyme1.72237109
27MP0002138_abnormal_hepatobiliary_system1.66796826
28MP0008057_abnormal_DNA_replication1.65542949
29MP0002118_abnormal_lipid_homeostasis1.63139102
30MP0003453_abnormal_keratinocyte_physiol1.47752504
31MP0005408_hypopigmentation1.45923666
32MP0003705_abnormal_hypodermis_morpholog1.45413438
33MP0001764_abnormal_homeostasis1.45184881
34MP0003693_abnormal_embryo_hatching1.44407851
35MP0002876_abnormal_thyroid_physiology1.43265183
36MP0002009_preneoplasia1.37181958
37MP0009643_abnormal_urine_homeostasis1.36315429
38MP0006035_abnormal_mitochondrial_morpho1.35697212
39MP0003656_abnormal_erythrocyte_physiolo1.28279482
40MP0008260_abnormal_autophagy1.25707312
41MP0005397_hematopoietic_system_phenotyp1.25685036
42MP0001545_abnormal_hematopoietic_system1.25685036
43MP0005647_abnormal_sex_gland1.21754934
44MP0008995_early_reproductive_senescence1.20277905
45MP0005584_abnormal_enzyme/coenzyme_acti1.16473607
46MP0005171_absent_coat_pigmentation1.15871016
47MP0000598_abnormal_liver_morphology1.14502387
48MP0002796_impaired_skin_barrier1.12748529
49MP0006082_CNS_inflammation1.10895194
50MP0008932_abnormal_embryonic_tissue1.08645178
51MP0009333_abnormal_splenocyte_physiolog1.06890719
52MP0004264_abnormal_extraembryonic_tissu1.06172109
53MP0003283_abnormal_digestive_organ1.05412129
54MP0004185_abnormal_adipocyte_glucose1.04070480
55MP0005666_abnormal_adipose_tissue1.00409216
56MP0004782_abnormal_surfactant_physiolog0.99786228
57MP0003879_abnormal_hair_cell0.99652356
58MP0005266_abnormal_metabolism0.99516902
59MP0005330_cardiomyopathy0.97891959
60MP0002249_abnormal_larynx_morphology0.97226221
61MP0009053_abnormal_anal_canal0.95326263
62MP0000685_abnormal_immune_system0.94538182
63MP0002254_reproductive_system_inflammat0.91426390
64MP0005376_homeostasis/metabolism_phenot0.91161444
65MP0002282_abnormal_trachea_morphology0.90295996
66MP0001881_abnormal_mammary_gland0.89894359
67MP0003011_delayed_dark_adaptation0.87912390
68MP0004957_abnormal_blastocyst_morpholog0.86931303
69MP0000371_diluted_coat_color0.86686425
70MP0004233_abnormal_muscle_weight0.85314737
71MP0003111_abnormal_nucleus_morphology0.84510593
72MP0003172_abnormal_lysosome_physiology0.84413407
73MP0002060_abnormal_skin_morphology0.84111578
74MP0000639_abnormal_adrenal_gland0.83817195
75MP0000579_abnormal_nail_morphology0.82643324
76MP0003638_abnormal_response/metabolism_0.81843716
77MP0004133_heterotaxia0.81523362
78MP0003075_altered_response_to0.81414730
79MP0000372_irregular_coat_pigmentation0.81135864
80MP0002132_abnormal_respiratory_system0.80938582
81MP0010352_gastrointestinal_tract_polyps0.80455314
82MP0009764_decreased_sensitivity_to0.78490547
83MP0009115_abnormal_fat_cell0.77511519
84MP0005451_abnormal_body_composition0.76500841
85MP0005220_abnormal_exocrine_pancreas0.76036037
86MP0003890_abnormal_embryonic-extraembry0.74669135
87MP0000681_abnormal_thyroid_gland0.74128627
88MP0005535_abnormal_body_temperature0.73441280
89MP0003718_maternal_effect0.73405468
90MP0005023_abnormal_wound_healing0.73259013
91MP0003077_abnormal_cell_cycle0.72429949
92MP0008872_abnormal_physiological_respon0.72254468
93MP0002136_abnormal_kidney_physiology0.70315249
94MP0005375_adipose_tissue_phenotype0.69516607
95MP0003868_abnormal_feces_composition0.69187003
96MP0008469_abnormal_protein_level0.68977874
97MP0005464_abnormal_platelet_physiology0.68747041
98MP0005248_abnormal_Harderian_gland0.68704975
99MP0005395_other_phenotype0.68416001
100MP0004858_abnormal_nervous_system0.67084317
101MP0005636_abnormal_mineral_homeostasis0.65486642
102MP0001727_abnormal_embryo_implantation0.65249720
103MP0002971_abnormal_brown_adipose0.64730057
104MP0000470_abnormal_stomach_morphology0.64399272
105MP0002078_abnormal_glucose_homeostasis0.64117903
106MP0009642_abnormal_blood_homeostasis0.63987530
107MP0003786_premature_aging0.63728837
108MP0001905_abnormal_dopamine_level0.63332362
109MP0010155_abnormal_intestine_physiology0.62413962
110MP0002166_altered_tumor_susceptibility0.62330862
111MP0005075_abnormal_melanosome_morpholog0.61909804
112MP0005501_abnormal_skin_physiology0.61905209
113MP0009763_increased_sensitivity_to0.61548212
114MP0005166_decreased_susceptibility_to0.61143442
115MP0000462_abnormal_digestive_system0.61025228
116MP0002970_abnormal_white_adipose0.60580453
117MP0010234_abnormal_vibrissa_follicle0.59079437
118MP0005187_abnormal_penis_morphology0.58051661
119MP0001756_abnormal_urination0.57921823
120MP0006036_abnormal_mitochondrial_physio0.57639516
121MP0008874_decreased_physiological_sensi0.57194832
122MP0000490_abnormal_crypts_of0.55170434
123MP0008058_abnormal_DNA_repair0.55046363
124MP0002086_abnormal_extraembryonic_tissu0.55032636
125MP0002269_muscular_atrophy0.54543384
126MP0005646_abnormal_pituitary_gland0.53954142
127MP0008873_increased_physiological_sensi0.53869576
128MP0000003_abnormal_adipose_tissue0.53745030
129MP0003878_abnormal_ear_physiology0.53070457
130MP0005377_hearing/vestibular/ear_phenot0.53070457
131MP0003566_abnormal_cell_adhesion0.51200111
132MP0005670_abnormal_white_adipose0.51150502
133MP0003119_abnormal_digestive_system0.51123515
134MP0001340_abnormal_eyelid_morphology0.51019532
135MP0003315_abnormal_perineum_morphology0.50737771
136MP0002653_abnormal_ependyma_morphology0.50610004
137MP0002090_abnormal_vision0.50470361
138MP0003123_paternal_imprinting0.50082708
139MP0002168_other_aberrant_phenotype0.49732138
140MP0001346_abnormal_lacrimal_gland0.49621321
141MP0005334_abnormal_fat_pad0.49343397
142MP0005076_abnormal_cell_differentiation0.49242018
143MP0002405_respiratory_system_inflammati0.48797146
144MP0004130_abnormal_muscle_cell0.48460862
145MP0009379_abnormal_foot_pigmentation0.45440209
146MP0009672_abnormal_birth_weight0.43710753
147MP0003953_abnormal_hormone_level0.43571321
148MP0005379_endocrine/exocrine_gland_phen0.42274066
149MP0010094_abnormal_chromosome_stability0.41465762
150MP0008007_abnormal_cellular_replicative0.41042510
151MP0003646_muscle_fatigue0.39968551

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.94828268
2Intrahepatic cholestasis (HP:0001406)5.41067994
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.28427357
4Hypobetalipoproteinemia (HP:0003563)4.95365635
5Deep venous thrombosis (HP:0002625)4.87464372
6Xanthomatosis (HP:0000991)4.57020551
7Hypochromic microcytic anemia (HP:0004840)4.14169905
8Abnormality of glutamine family amino acid metabolism (HP:0010902)4.06153457
9Prolonged partial thromboplastin time (HP:0003645)4.00594514
10Hyperammonemia (HP:0001987)3.97187790
11Pustule (HP:0200039)3.94507957
12Hyperglycinuria (HP:0003108)3.85970552
13Alopecia of scalp (HP:0002293)3.85595757
14Turricephaly (HP:0000262)3.71580149
15Ketosis (HP:0001946)3.68562190
16Abnormal mitochondria in muscle tissue (HP:0008316)3.62788956
17Hypolipoproteinemia (HP:0010981)3.58851272
18Acute encephalopathy (HP:0006846)3.56832588
19Hyperlipoproteinemia (HP:0010980)3.51825852
20Hyperglycinemia (HP:0002154)3.46787325
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.45454093
22Fat malabsorption (HP:0002630)3.43071779
23Cholecystitis (HP:0001082)3.43028353
24Abnormal gallbladder physiology (HP:0012438)3.43028353
25Abnormality of glycine metabolism (HP:0010895)3.41656739
26Abnormality of serine family amino acid metabolism (HP:0010894)3.41656739
27Complement deficiency (HP:0004431)3.41324540
28Abnormal hemoglobin (HP:0011902)3.39476319
29Myocardial infarction (HP:0001658)3.34138964
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.32136060
31Acute necrotizing encephalopathy (HP:0006965)3.22438598
32Increased muscle lipid content (HP:0009058)3.19780026
33Ketoacidosis (HP:0001993)3.19604141
34Cerebral edema (HP:0002181)3.19149631
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.14359933
36Joint hemorrhage (HP:0005261)3.13382633
37Increased intramyocellular lipid droplets (HP:0012240)3.10720608
38Abnormality of glycolysis (HP:0004366)3.09600009
39Abnormality of methionine metabolism (HP:0010901)3.08769758
40Mitochondrial inheritance (HP:0001427)3.08139424
41Abnormality of pyrimidine metabolism (HP:0004353)3.06977874
42Hepatic necrosis (HP:0002605)3.04126798
43Urinary glycosaminoglycan excretion (HP:0003541)3.02561957
44Mucopolysacchariduria (HP:0008155)3.02561957
45Cholelithiasis (HP:0001081)3.01182190
46Hepatocellular necrosis (HP:0001404)2.99129473
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.96626778
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.96626778
49Hypoalphalipoproteinemia (HP:0003233)2.94284485
50Increased serum pyruvate (HP:0003542)2.93835255
51Ulnar bowing (HP:0003031)2.91010661
52Gout (HP:0001997)2.90570246
53Steatorrhea (HP:0002570)2.90003462
54Polycythemia (HP:0001901)2.85648589
55Abnormality of complement system (HP:0005339)2.85510221
56Abnormality of fatty-acid metabolism (HP:0004359)2.82930025
57Vaginal fistula (HP:0004320)2.78670936
58Increased CSF lactate (HP:0002490)2.78330679
59Glomerulonephritis (HP:0000099)2.78185050
60Congenital malformation of the right heart (HP:0011723)2.76162052
61Double outlet right ventricle (HP:0001719)2.76162052
62Abnormal gallbladder morphology (HP:0012437)2.74549740
63Ragged-red muscle fibers (HP:0003200)2.74130959
64Abnormality of nucleobase metabolism (HP:0010932)2.74127002
65Abnormality of mucopolysaccharide metabolism (HP:0011020)2.74050390
66Abnormality of polysaccharide metabolism (HP:0011012)2.74050390
67Abnormality of glycosaminoglycan metabolism (HP:0004371)2.74050390
68Epidermoid cyst (HP:0200040)2.73739080
69Renal Fanconi syndrome (HP:0001994)2.71458673
70Malnutrition (HP:0004395)2.70763052
71Reduced antithrombin III activity (HP:0001976)2.70405614
72Increased IgM level (HP:0003496)2.68940606
73Abnormality of the common coagulation pathway (HP:0010990)2.67390962
74Lactic acidosis (HP:0003128)2.61874189
75Poikiloderma (HP:0001029)2.61095085
76Delayed CNS myelination (HP:0002188)2.60354117
77Hypoglycemic coma (HP:0001325)2.59410320
78Dysostosis multiplex (HP:0000943)2.58083391
79Abnormality of purine metabolism (HP:0004352)2.57701566
80Abnormality of the gallbladder (HP:0005264)2.51097203
81Opisthotonus (HP:0002179)2.49734405
82Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.47786377
83Rib fusion (HP:0000902)2.46838936
84Coronal craniosynostosis (HP:0004440)2.46366558
85Increased serum lactate (HP:0002151)2.45038375
86Concave nail (HP:0001598)2.43393316
87Annular pancreas (HP:0001734)2.42707690
88Hypercholesterolemia (HP:0003124)2.42664490
89Spastic diplegia (HP:0001264)2.42275931
90Hyperphosphaturia (HP:0003109)2.42013354
91Progressive macrocephaly (HP:0004481)2.41693123
92Abnormality of the intrinsic pathway (HP:0010989)2.39094130
93Spontaneous abortion (HP:0005268)2.38315040
94Abnormal enzyme/coenzyme activity (HP:0012379)2.38297994
95Cerebral palsy (HP:0100021)2.38010098
96Rectal fistula (HP:0100590)2.35380005
97Rectovaginal fistula (HP:0000143)2.35380005
98Hypochromic anemia (HP:0001931)2.33338644
99Lethargy (HP:0001254)2.33217105
100Abnormality of proline metabolism (HP:0010907)2.32592337
101Hydroxyprolinuria (HP:0003080)2.32592337
102Lipid accumulation in hepatocytes (HP:0006561)2.30967591
103Purpura (HP:0000979)2.29852575
104Hepatocellular carcinoma (HP:0001402)2.29597805
105Esophageal varix (HP:0002040)2.28212517
106Exercise intolerance (HP:0003546)2.27098805
107Truncus arteriosus (HP:0001660)2.26447603
108Glycosuria (HP:0003076)2.22691213
109Abnormality of urine glucose concentration (HP:0011016)2.22691213
110Hyperthyroidism (HP:0000836)2.22391586
111Hyperbilirubinemia (HP:0002904)2.22091224
112Abnormality of alkaline phosphatase activity (HP:0004379)2.21010566
113Vascular calcification (HP:0004934)2.20182479
114Recurrent gram-negative bacterial infections (HP:0005420)2.19556075
115Systemic lupus erythematosus (HP:0002725)2.16392068
116Seborrheic dermatitis (HP:0001051)2.16251782
117Irritability (HP:0000737)2.15816670
118Abnormality of serum amino acid levels (HP:0003112)2.15114063
119Lower limb hyperreflexia (HP:0002395)2.13279396
120Hypoplastic left heart (HP:0004383)2.13152225
121Increased hepatocellular lipid droplets (HP:0006565)2.11846258
122Abnormality of the Achilles tendon (HP:0005109)2.08813276
123Dicarboxylic aciduria (HP:0003215)2.08041471
124Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08041471
125Microvesicular hepatic steatosis (HP:0001414)2.07883748
126Type I transferrin isoform profile (HP:0003642)2.05808738
127Metabolic acidosis (HP:0001942)2.04762897
128Menorrhagia (HP:0000132)2.04420853
129Tongue fasciculations (HP:0001308)2.04119817
130Testicular atrophy (HP:0000029)2.02155947
131Respiratory failure (HP:0002878)2.01972804
132Pancreatic islet-cell hyperplasia (HP:0004510)2.01539027
133Alkalosis (HP:0001948)1.99749620
134Abnormal urine phosphate concentration (HP:0012599)1.98808598
135Microretrognathia (HP:0000308)1.98050156
136Prolonged neonatal jaundice (HP:0006579)1.97522524
137Vomiting (HP:0002013)1.97457537
138Hypokinesia (HP:0002375)1.97198925
139Proximal tubulopathy (HP:0000114)1.97016922
140Nephritis (HP:0000123)1.96981469
141Generalized aminoaciduria (HP:0002909)1.96615079
142Rickets (HP:0002748)1.96322352
143Facial hemangioma (HP:0000329)1.95843460
144Intestinal fistula (HP:0100819)1.95838370
145Cardiovascular calcification (HP:0011915)1.94859957
146Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93930006
147Acute hepatic failure (HP:0006554)1.93714442
148Bilateral sensorineural hearing impairment (HP:0008619)1.93180827
149Abnormality of male internal genitalia (HP:0000022)1.93032272
150Increased purine levels (HP:0004368)1.92999159
151Hyperuricemia (HP:0002149)1.92999159
152Conjugated hyperbilirubinemia (HP:0002908)1.92825028
153Increased mean platelet volume (HP:0011877)1.91141549
154Hemorrhage of the eye (HP:0011885)1.88369953
155Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81636345
156Spastic paraparesis (HP:0002313)1.80530571

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.64385051
2MAPK154.70551784
3ICK4.68709405
4SMG14.56729514
5DDR24.36751590
6MAP3K113.78800077
7MAP3K63.63350252
8BUB13.56647805
9PINK13.24684007
10BCKDK3.17497860
11STK162.86180593
12MATK2.75157145
13PIM22.58326036
14TESK12.49921635
15TESK22.43982773
16ERN12.30609177
17TAF12.26910870
18CSK2.25950810
19FGR2.25567367
20IRAK32.19505525
21DYRK1B2.14747206
22BMX2.11721227
23TYRO32.01567592
24PRKD31.93469611
25ARAF1.85303376
26SCYL21.84879772
27DAPK11.82636942
28SIK11.74484266
29PRKD21.73297300
30PDGFRA1.72155592
31CDK61.72099335
32EPHA21.63672455
33VRK11.56429181
34TLK11.55875362
35CSNK1G31.52656018
36PIM11.44332040
37NME11.42164433
38TRIB31.40264613
39MAPK111.39943773
40TRPM71.39006061
41TAOK21.37661612
42YES11.34894102
43FGFR41.31632251
44GSK3A1.29539816
45MAPKAPK51.21795201
46NUAK11.20257578
47DAPK31.17927631
48AKT31.17648782
49MAP3K31.16259500
50BRSK11.15853670
51AURKA1.13964617
52BRAF1.12892756
53CSNK1A1L1.11544935
54CDK71.11430328
55ILK1.10955511
56ZAK1.07124396
57LATS21.06007795
58PDK21.05452130
59RPS6KC11.05026749
60RPS6KL11.05026749
61RIPK10.99659958
62UHMK10.98737802
63MAP2K30.98262289
64RPS6KA60.95707474
65GRK50.95671162
66CSNK1G20.95181677
67PBK0.94940630
68LIMK10.91856178
69MST1R0.84503909
70MAP3K100.83785976
71NEK10.80611011
72TNK20.77842874
73PRKCI0.77616876
74FLT30.77348189
75EIF2AK10.75812958
76MAP3K120.72011999
77AKT20.71861427
78LATS10.71619359
79STK38L0.68972969
80RPS6KB20.66018391
81IRAK20.65907702
82RPS6KA50.65856419
83CCNB10.65372560
84CAMK1D0.62503301
85TTK0.61571053
86PRKAA10.61526033
87ERBB40.61094526
88STK40.60888067
89PTK20.60770367
90PRKAA20.60339651
91MTOR0.59974749
92CDC42BPA0.59965934
93ABL20.59765484
94TYK20.59478538
95EPHB10.58994861
96RPS6KA10.58675813
97EGFR0.58300491
98TBK10.58268798
99DYRK30.57567826
100IKBKB0.57210626
101CAMK2G0.56224162
102PRPF4B0.55911039
103EEF2K0.55442477
104MAPK40.54959372
105PHKG10.52999246
106PHKG20.52999246
107TAOK10.51730933
108AURKB0.51206113
109DYRK20.50910937
110CHUK0.50732592
111JAK20.49995703
112CDK90.49514520
113MAP2K20.47591335
114CSNK2A20.47190263
115MAP3K140.46904607
116LYN0.44727657
117PDPK10.42798907
118PRKCZ0.42754293
119TAOK30.42684661
120PTK60.40769161
121ATR0.40447779
122MAP3K80.40396695
123PAK40.38840877
124PLK10.38145872
125MAPK30.37337187
126HIPK20.36963190
127SRPK10.36484213
128MET0.36431184
129WEE10.36286243
130NME20.35648211
131CDK11A0.35576084
132EIF2AK20.35264549
133PAK10.35149790
134MAP3K10.35049101
135CDC70.34527309
136TGFBR20.34486784
137KDR0.34148225
138CDK80.33804687
139CSNK2A10.33394601
140FRK0.32528424
141STK30.32488587
142CDK150.31876033
143PIK3CG0.31872787
144CDK40.31831916
145MAPKAPK30.31768048
146MUSK0.31433393
147ABL10.30803159
148PRKCD0.30152992
149MAPK120.29726602
150STK100.29481125
151GRK60.28900239
152CDK140.28840836
153PDGFRB0.28355175
154MAP4K10.27982165
155BLK0.27924223
156PKN20.27565606
157CDK180.27408845
158CHEK20.27367613
159MAPK10.25480888
160LRRK20.25107825
161MAPKAPK20.25090739
162MST40.24666013
163CSNK1G10.24210710
164CAMK2D0.23810348
165PRKACG0.23755955
166INSR0.22828913

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.62272195
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.60257628
3Arginine biosynthesis_Homo sapiens_hsa002202.87061341
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.69574186
5* Pentose and glucuronate interconversions_Homo sapiens_hsa000402.62168918
6Nitrogen metabolism_Homo sapiens_hsa009102.49454784
7Tryptophan metabolism_Homo sapiens_hsa003802.34562741
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.32485487
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.28776763
10Fatty acid biosynthesis_Homo sapiens_hsa000612.28673241
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.25574266
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.20189910
13Fatty acid degradation_Homo sapiens_hsa000712.16632487
14Fatty acid metabolism_Homo sapiens_hsa012122.10433586
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.09998094
16Chemical carcinogenesis_Homo sapiens_hsa052042.05071104
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.04819246
18Sulfur relay system_Homo sapiens_hsa041221.98345344
19Complement and coagulation cascades_Homo sapiens_hsa046101.97259908
20Peroxisome_Homo sapiens_hsa041461.93990707
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.90280434
22Butanoate metabolism_Homo sapiens_hsa006501.89472542
23Sulfur metabolism_Homo sapiens_hsa009201.80047142
24Ribosome_Homo sapiens_hsa030101.79958419
25Folate biosynthesis_Homo sapiens_hsa007901.78568942
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.74220420
27Arginine and proline metabolism_Homo sapiens_hsa003301.73085319
28Oxidative phosphorylation_Homo sapiens_hsa001901.70608588
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.69490654
30Histidine metabolism_Homo sapiens_hsa003401.69036420
31Propanoate metabolism_Homo sapiens_hsa006401.66071483
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65807664
33Selenocompound metabolism_Homo sapiens_hsa004501.59243719
34Biosynthesis of amino acids_Homo sapiens_hsa012301.57780843
35beta-Alanine metabolism_Homo sapiens_hsa004101.55760469
36PPAR signaling pathway_Homo sapiens_hsa033201.52620264
37Retinol metabolism_Homo sapiens_hsa008301.49588355
38Parkinsons disease_Homo sapiens_hsa050121.47278370
39Caffeine metabolism_Homo sapiens_hsa002321.44425321
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43862798
41Proteasome_Homo sapiens_hsa030501.40108749
42Starch and sucrose metabolism_Homo sapiens_hsa005001.36149909
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34195179
44Glutathione metabolism_Homo sapiens_hsa004801.32540367
45Staphylococcus aureus infection_Homo sapiens_hsa051501.32444506
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31101903
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.29606490
48Phenylalanine metabolism_Homo sapiens_hsa003601.25598232
49Bile secretion_Homo sapiens_hsa049761.15525501
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.14698552
51Fatty acid elongation_Homo sapiens_hsa000621.13063959
52Pyruvate metabolism_Homo sapiens_hsa006201.12945855
53Steroid biosynthesis_Homo sapiens_hsa001001.10146302
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07335644
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.06491740
56Fat digestion and absorption_Homo sapiens_hsa049751.02958334
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01935628
58Carbon metabolism_Homo sapiens_hsa012001.00912201
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99176162
60ABC transporters_Homo sapiens_hsa020100.98522867
61Tyrosine metabolism_Homo sapiens_hsa003500.98375148
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94558428
63Lysine degradation_Homo sapiens_hsa003100.94205709
64Alzheimers disease_Homo sapiens_hsa050100.92850136
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92759101
66Fructose and mannose metabolism_Homo sapiens_hsa000510.89366521
67Huntingtons disease_Homo sapiens_hsa050160.88002515
68Pyrimidine metabolism_Homo sapiens_hsa002400.83229306
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82199840
70Base excision repair_Homo sapiens_hsa034100.79061472
71One carbon pool by folate_Homo sapiens_hsa006700.77986361
72Galactose metabolism_Homo sapiens_hsa000520.75422856
73Vitamin digestion and absorption_Homo sapiens_hsa049770.74764954
74Glycerolipid metabolism_Homo sapiens_hsa005610.67907387
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67480633
76Mismatch repair_Homo sapiens_hsa034300.63651377
77RNA polymerase_Homo sapiens_hsa030200.61561201
78Pentose phosphate pathway_Homo sapiens_hsa000300.59518010
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55736340
80Other glycan degradation_Homo sapiens_hsa005110.52617578
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.48563496
82* Metabolic pathways_Homo sapiens_hsa011000.46302964
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45715027
84Bladder cancer_Homo sapiens_hsa052190.44984736
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36088098
86Systemic lupus erythematosus_Homo sapiens_hsa053220.34312713
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32522573
88N-Glycan biosynthesis_Homo sapiens_hsa005100.30711497
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29539105
90Homologous recombination_Homo sapiens_hsa034400.28342940
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27215251
92Circadian rhythm_Homo sapiens_hsa047100.27019917
93Spliceosome_Homo sapiens_hsa030400.27011637
94Prion diseases_Homo sapiens_hsa050200.25092852
95Linoleic acid metabolism_Homo sapiens_hsa005910.25084328
96Mineral absorption_Homo sapiens_hsa049780.24449923
97Vitamin B6 metabolism_Homo sapiens_hsa007500.22331139
98Notch signaling pathway_Homo sapiens_hsa043300.21803587
99Cardiac muscle contraction_Homo sapiens_hsa042600.21254371
100Purine metabolism_Homo sapiens_hsa002300.21046799
101Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.21043550
102Vibrio cholerae infection_Homo sapiens_hsa051100.20656815
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19812384
104Adherens junction_Homo sapiens_hsa045200.19591445
105Legionellosis_Homo sapiens_hsa051340.16303765
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.15852501
107DNA replication_Homo sapiens_hsa030300.15551394
108mTOR signaling pathway_Homo sapiens_hsa041500.15199739
109Lysosome_Homo sapiens_hsa041420.15061631
110Hippo signaling pathway_Homo sapiens_hsa043900.14645808
111p53 signaling pathway_Homo sapiens_hsa041150.14004477
112Nucleotide excision repair_Homo sapiens_hsa034200.12788143
113Glucagon signaling pathway_Homo sapiens_hsa049220.09258629
114Hedgehog signaling pathway_Homo sapiens_hsa043400.09131127
115AMPK signaling pathway_Homo sapiens_hsa041520.07886116
116Arachidonic acid metabolism_Homo sapiens_hsa005900.07746762
117TGF-beta signaling pathway_Homo sapiens_hsa043500.07619400
118Shigellosis_Homo sapiens_hsa051310.07309815
119Collecting duct acid secretion_Homo sapiens_hsa049660.05051544
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.02735664
121Renin-angiotensin system_Homo sapiens_hsa046140.00568929
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0210977
123Insulin resistance_Homo sapiens_hsa04931-0.0095429
124Transcriptional misregulation in cancer_Homo sapiens_hsa05202-0.0076113

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