DCX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase catabolic process (GO:0046113)8.50836993
2layer formation in cerebral cortex (GO:0021819)6.38431677
3cell migration in hindbrain (GO:0021535)6.24981436
4neuron cell-cell adhesion (GO:0007158)6.14754601
5neuron recognition (GO:0008038)5.61917738
6axonal fasciculation (GO:0007413)5.49577350
7* central nervous system projection neuron axonogenesis (GO:0021952)5.25306728
8dendritic spine morphogenesis (GO:0060997)5.04999710
9vocalization behavior (GO:0071625)5.04326972
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.01517235
11* dendrite morphogenesis (GO:0048813)4.85570214
12cerebral cortex radially oriented cell migration (GO:0021799)4.82360715
13establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.80824834
14mitochondrion transport along microtubule (GO:0047497)4.80824834
15postsynaptic membrane organization (GO:0001941)4.76492707
16protein localization to synapse (GO:0035418)4.69258817
17establishment of mitochondrion localization (GO:0051654)4.67421031
18negative regulation of microtubule polymerization (GO:0031115)4.52579032
19positive regulation of synapse maturation (GO:0090129)4.41423815
20regulation of glutamate receptor signaling pathway (GO:1900449)4.38759005
21regulation of short-term neuronal synaptic plasticity (GO:0048172)4.18620543
22regulation of synapse structural plasticity (GO:0051823)4.14965912
23exploration behavior (GO:0035640)4.14757798
24presynaptic membrane assembly (GO:0097105)4.10737564
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.09328573
26* axon extension (GO:0048675)4.07230630
27limb bud formation (GO:0060174)4.03820054
28* central nervous system neuron axonogenesis (GO:0021955)3.99114358
29presynaptic membrane organization (GO:0097090)3.98110239
30locomotory exploration behavior (GO:0035641)3.95898239
31hippocampus development (GO:0021766)3.93739081
32positive regulation of filopodium assembly (GO:0051491)3.93057626
33clathrin coat assembly (GO:0048268)3.91373703
34positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.91066931
35neural tube formation (GO:0001841)3.86880519
36glial cell proliferation (GO:0014009)3.86388660
37synaptic vesicle maturation (GO:0016188)3.83682135
38retinal ganglion cell axon guidance (GO:0031290)3.82617221
39sympathetic nervous system development (GO:0048485)3.81248306
40cerebellum development (GO:0021549)3.79150389
41response to pheromone (GO:0019236)3.77494990
42regulation of axon extension (GO:0030516)3.77357361
43neurotransmitter-gated ion channel clustering (GO:0072578)3.72924197
44positive regulation of axon extension (GO:0045773)3.71090952
45regulation of synapse maturation (GO:0090128)3.66304490
46positive regulation of dendritic spine morphogenesis (GO:0061003)3.66186985
47positive regulation of synapse assembly (GO:0051965)3.64167919
48positive regulation of microtubule polymerization or depolymerization (GO:0031112)3.61697534
49regulation of synaptic vesicle exocytosis (GO:2000300)3.58503889
50negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.57730591
51ionotropic glutamate receptor signaling pathway (GO:0035235)3.56994137
52synaptic vesicle exocytosis (GO:0016079)3.56390400
53* neuron migration (GO:0001764)3.54564881
54regulation of microtubule polymerization (GO:0031113)3.52330289
55* neuron projection extension (GO:1990138)3.52270021
56dopamine receptor signaling pathway (GO:0007212)3.48906902
57negative regulation of axon extension (GO:0030517)3.48572917
58regulation of extent of cell growth (GO:0061387)3.48542273
59olfactory bulb development (GO:0021772)3.48302243
60synapse assembly (GO:0007416)3.41724764
61regulation of dendritic spine morphogenesis (GO:0061001)3.41483298
62regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.40474247
63positive regulation of amino acid transport (GO:0051957)3.40255857
64dendrite development (GO:0016358)3.38579335
65mechanosensory behavior (GO:0007638)3.35271414
66cerebral cortex neuron differentiation (GO:0021895)3.34243160
67negative regulation of dendrite development (GO:2000171)3.33962446
68proline transport (GO:0015824)3.33440603
69regulation of cAMP-dependent protein kinase activity (GO:2000479)3.32256232
70cerebellar granule cell differentiation (GO:0021707)3.31819445
71spinal cord development (GO:0021510)3.29440845
72glutamate secretion (GO:0014047)3.29169674
73regulation of NFAT protein import into nucleus (GO:0051532)3.28973879
74adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.26026603
75regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.23001531
76cardiac ventricle formation (GO:0003211)3.22371317
77glutamate receptor signaling pathway (GO:0007215)3.21504215
78negative regulation of axonogenesis (GO:0050771)3.21307527
79behavioral response to nicotine (GO:0035095)3.20026565
80cerebral cortex cell migration (GO:0021795)3.19136324
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.18281799
82auditory behavior (GO:0031223)3.17693779
83positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.17606225
84synaptic vesicle docking involved in exocytosis (GO:0016081)3.17326854
85regulation of synapse assembly (GO:0051963)3.14631389
86glycosphingolipid biosynthetic process (GO:0006688)3.14577851
87regulation of synapse organization (GO:0050807)3.12700217
88transmission of nerve impulse (GO:0019226)3.11366619
89startle response (GO:0001964)3.10984562
90regulation of filopodium assembly (GO:0051489)3.10296870
91organelle transport along microtubule (GO:0072384)3.07605505
92synaptic transmission, glutamatergic (GO:0035249)3.06092979
93regulation of synaptic vesicle transport (GO:1902803)3.06040498
94cellular response to prostaglandin stimulus (GO:0071379)3.05142268
95homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)3.03820533
96epithelial cell differentiation involved in kidney development (GO:0035850)3.03714297
97positive regulation of dendritic spine development (GO:0060999)3.01797375
98histone H3-K4 trimethylation (GO:0080182)3.01079901
99* axonogenesis (GO:0007409)3.01018114
100regulation of axon guidance (GO:1902667)3.00414710
101regulation of long-term neuronal synaptic plasticity (GO:0048169)2.97824158
102* neuron projection morphogenesis (GO:0048812)2.96669789
103neuron-neuron synaptic transmission (GO:0007270)2.95956013
104positive regulation of microtubule polymerization (GO:0031116)2.95803106
105gamma-aminobutyric acid transport (GO:0015812)2.95575441
106cardiac chamber formation (GO:0003207)2.95505871
107heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.94950554
108regulation of neuronal synaptic plasticity (GO:0048168)2.94307536
109negative regulation of axon guidance (GO:1902668)2.94103487
110regulation of dendritic spine development (GO:0060998)2.93710480
111regulation of respiratory system process (GO:0044065)2.93416382
112regulation of axon extension involved in axon guidance (GO:0048841)2.93246301
113synapse organization (GO:0050808)2.93112744
114neurotransmitter secretion (GO:0007269)2.92867942
115forebrain neuron differentiation (GO:0021879)2.91342062
116neuronal action potential (GO:0019228)2.91260360
117neurofilament cytoskeleton organization (GO:0060052)2.90282433
118spinal cord motor neuron differentiation (GO:0021522)2.89922501
119membrane assembly (GO:0071709)2.89055028
120regulation of axonogenesis (GO:0050770)2.88782022
121G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.88544740
122positive regulation of oligodendrocyte differentiation (GO:0048714)2.88219436
123atrial cardiac muscle cell action potential (GO:0086014)2.88137193
124neuromuscular synaptic transmission (GO:0007274)2.86736616
125response to auditory stimulus (GO:0010996)2.85494228
126regulation of synaptic transmission, glutamatergic (GO:0051966)2.85207808
127regulation of timing of cell differentiation (GO:0048505)2.84769125
128membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.83972810
129somite development (GO:0061053)2.76164335
130regulation of development, heterochronic (GO:0040034)2.75004477
131negative regulation of translation, ncRNA-mediated (GO:0040033)2.74757462
132regulation of translation, ncRNA-mediated (GO:0045974)2.74757462
133negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.74757462
134calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.72720212
135G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72504899
136regulation of collateral sprouting (GO:0048670)2.72016542
137neuron fate determination (GO:0048664)2.70389369
138negative chemotaxis (GO:0050919)2.65502361
139behavioral response to ethanol (GO:0048149)2.65093330
140pyrimidine nucleobase catabolic process (GO:0006208)10.7270735

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.20188700
2GBX2_23144817_ChIP-Seq_PC3_Human3.49481914
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.24553589
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91692062
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.88774882
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.87887640
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74818005
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.56312052
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.51401781
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42836958
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.41614490
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41209472
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41209472
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.36769667
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35551637
16RNF2_27304074_Chip-Seq_ESCs_Mouse2.23726544
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22038299
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.20236214
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19061230
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18552689
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11578182
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.11542956
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.10899596
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10284566
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09860507
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06382498
27CBX2_27304074_Chip-Seq_ESCs_Mouse2.04507324
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.99862995
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93770855
30* REST_18959480_ChIP-ChIP_MESCs_Mouse1.91737365
31AR_21572438_ChIP-Seq_LNCaP_Human1.89017978
32DROSHA_22980978_ChIP-Seq_HELA_Human1.88641506
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88439056
34VDR_22108803_ChIP-Seq_LS180_Human1.85051267
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75411685
36ZNF274_21170338_ChIP-Seq_K562_Hela1.74800372
37IGF1R_20145208_ChIP-Seq_DFB_Human1.73062210
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.71978671
39RNF2_27304074_Chip-Seq_NSC_Mouse1.70468945
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68109400
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65289573
42* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64968428
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60359466
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59034063
45RING1B_27294783_Chip-Seq_NPCs_Mouse1.56440781
46TAF15_26573619_Chip-Seq_HEK293_Human1.56367240
47EWS_26573619_Chip-Seq_HEK293_Human1.55352975
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52846875
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.50895391
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48554241
51* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47068736
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44967467
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44967467
54P300_19829295_ChIP-Seq_ESCs_Human1.44251519
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40028535
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37576006
57* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37325497
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.35033249
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.34160993
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33852707
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33648903
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33300865
63CBP_20019798_ChIP-Seq_JUKART_Human1.33300865
64SMAD4_21799915_ChIP-Seq_A2780_Human1.32107784
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.32043229
66* SOX2_21211035_ChIP-Seq_LN229_Gbm1.29629379
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28904049
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27154024
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27036588
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.26036440
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25070117
72* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23996281
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.22901379
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.22588008
75EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20788425
76* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.20541675
77BCAT_22108803_ChIP-Seq_LS180_Human1.19493995
78LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18511261
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18395668
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18387187
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16630016
82AR_25329375_ChIP-Seq_VCAP_Human1.16605941
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.15416228
84AHR_22903824_ChIP-Seq_MCF-7_Human1.15266035
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14991141
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14293415
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14221921
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14077166
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12824170
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12587090
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.12177812
92FUS_26573619_Chip-Seq_HEK293_Human1.11961673
93AR_19668381_ChIP-Seq_PC3_Human1.11118677
94KDM2B_26808549_Chip-Seq_REH_Human1.10404890
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09844825
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08679113
97SOX9_26525672_Chip-Seq_HEART_Mouse1.08128615
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06830403
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06626867
100STAT3_23295773_ChIP-Seq_U87_Human1.05584277
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04977832
102CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04963258
103RUNX2_22187159_ChIP-Seq_PCA_Human1.03911299
104CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03205584
105POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01745148
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01447018
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01338067
108ER_23166858_ChIP-Seq_MCF-7_Human1.00572100
109NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00332519
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99853746
111KDM2B_26808549_Chip-Seq_K562_Human0.99838826
112RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99726162
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98866218
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97855756
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.96818748
116TCF4_23295773_ChIP-Seq_U87_Human0.96144936
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96066340
118SMAD3_21741376_ChIP-Seq_ESCs_Human0.95245170
119TP53_18474530_ChIP-ChIP_U2OS_Human0.94830643
120* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94593311
121ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94251219
122JUN_21703547_ChIP-Seq_K562_Human0.93378806
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91494225
124PRDM14_20953172_ChIP-Seq_ESCs_Human0.91475205

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.53835134
2MP0000778_abnormal_nervous_system3.97081138
3MP0005423_abnormal_somatic_nervous3.87431078
4MP0004270_analgesia3.86534440
5MP0003880_abnormal_central_pattern3.64252055
6* MP0003635_abnormal_synaptic_transmissio3.13721156
7MP0000569_abnormal_digit_pigmentation3.11527015
8* MP0002063_abnormal_learning/memory/cond2.84176851
9MP0002822_catalepsy2.81344228
10MP0002734_abnormal_mechanical_nocicepti2.70097963
11MP0002184_abnormal_innervation2.68376267
12MP0002735_abnormal_chemical_nociception2.40420931
13MP0006276_abnormal_autonomic_nervous2.39365679
14MP0000537_abnormal_urethra_morphology2.33422647
15MP0002572_abnormal_emotion/affect_behav2.19749040
16MP0009745_abnormal_behavioral_response2.19640976
17MP0004811_abnormal_neuron_physiology2.11674545
18MP0002733_abnormal_thermal_nociception2.11592387
19MP0001968_abnormal_touch/_nociception2.08423762
20MP0002557_abnormal_social/conspecific_i2.03462638
21MP0000955_abnormal_spinal_cord1.97934518
22MP0002102_abnormal_ear_morphology1.93328677
23MP0001486_abnormal_startle_reflex1.92051351
24MP0008789_abnormal_olfactory_epithelium1.91494414
25MP0003787_abnormal_imprinting1.90344661
26MP0004858_abnormal_nervous_system1.87428207
27MP0001188_hyperpigmentation1.84303321
28MP0002064_seizures1.83457026
29MP0005499_abnormal_olfactory_system1.79400906
30MP0005394_taste/olfaction_phenotype1.79400906
31MP0004885_abnormal_endolymph1.76610033
32MP0009780_abnormal_chondrocyte_physiolo1.73293765
33MP0001440_abnormal_grooming_behavior1.72783905
34MP0005645_abnormal_hypothalamus_physiol1.70799216
35MP0006292_abnormal_olfactory_placode1.67195635
36MP0001970_abnormal_pain_threshold1.66300354
37MP0000631_abnormal_neuroendocrine_gland1.65978486
38MP0001984_abnormal_olfaction1.65274599
39MP0002882_abnormal_neuron_morphology1.64309411
40* MP0002152_abnormal_brain_morphology1.60591126
41* MP0003861_abnormal_nervous_system1.57456611
42MP0009046_muscle_twitch1.57188514
43MP0005187_abnormal_penis_morphology1.56353684
44MP0002067_abnormal_sensory_capabilities1.54017094
45MP0008877_abnormal_DNA_methylation1.47680853
46MP0002736_abnormal_nociception_after1.45287271
47MP0003119_abnormal_digestive_system1.43833983
48* MP0004924_abnormal_behavior1.41652571
49* MP0005386_behavior/neurological_phenoty1.41652571
50MP0005551_abnormal_eye_electrophysiolog1.30628973
51MP0004742_abnormal_vestibular_system1.29417780
52MP0003329_amyloid_beta_deposits1.29298887
53MP0004133_heterotaxia1.29250050
54MP0004142_abnormal_muscle_tone1.28128480
55MP0003890_abnormal_embryonic-extraembry1.27653489
56MP0002751_abnormal_autonomic_nervous1.27192194
57MP0005248_abnormal_Harderian_gland1.24662853
58* MP0002066_abnormal_motor_capabilities/c1.24300980
59MP0002909_abnormal_adrenal_gland1.23887331
60MP0002272_abnormal_nervous_system1.22954656
61MP0009379_abnormal_foot_pigmentation1.22539409
62MP0003938_abnormal_ear_development1.18124819
63MP0002234_abnormal_pharynx_morphology1.11326628
64MP0000015_abnormal_ear_pigmentation1.11245067
65MP0002752_abnormal_somatic_nervous1.10718833
66MP0001348_abnormal_lacrimal_gland1.10557189
67MP0001529_abnormal_vocalization1.09106077
68MP0006072_abnormal_retinal_apoptosis1.02565515
69MP0002081_perinatal_lethality1.00655549
70MP0003385_abnormal_body_wall1.00370346
71MP0008569_lethality_at_weaning1.00300259
72MP0005253_abnormal_eye_physiology0.95917342
73MP0000566_synostosis0.95488973
74MP0005646_abnormal_pituitary_gland0.93628624
75MP0002069_abnormal_eating/drinking_beha0.92824205
76MP0005195_abnormal_posterior_eye0.89585189
77MP0001501_abnormal_sleep_pattern0.87441000
78MP0002638_abnormal_pupillary_reflex0.86863598
79MP0000026_abnormal_inner_ear0.86779408
80MP0000049_abnormal_middle_ear0.85833979
81MP0003937_abnormal_limbs/digits/tail_de0.85410734
82MP0003122_maternal_imprinting0.84535104
83MP0003121_genomic_imprinting0.84514881
84MP0003935_abnormal_craniofacial_develop0.84394318
85MP0000647_abnormal_sebaceous_gland0.83923341
86MP0001502_abnormal_circadian_rhythm0.83256886
87MP0010386_abnormal_urinary_bladder0.83181873
88MP0003755_abnormal_palate_morphology0.81785567
89MP0003137_abnormal_impulse_conducting0.81719340
90MP0002116_abnormal_craniofacial_bone0.81505109
91MP0001905_abnormal_dopamine_level0.79808983
92MP0003942_abnormal_urinary_system0.79776779
93MP0002233_abnormal_nose_morphology0.79009842
94MP0004085_abnormal_heartbeat0.77195170
95MP0003634_abnormal_glial_cell0.76835125
96MP0001177_atelectasis0.75153280
97MP0005367_renal/urinary_system_phenotyp0.74240484
98MP0000516_abnormal_urinary_system0.74240484
99MP0002653_abnormal_ependyma_morphology0.73890643
100MP0003315_abnormal_perineum_morphology0.73770777
101MP0000534_abnormal_ureter_morphology0.73580047
102MP0005409_darkened_coat_color0.73301213
103MP0001986_abnormal_taste_sensitivity0.73040948
104MP0001963_abnormal_hearing_physiology0.72671157
105MP0003879_abnormal_hair_cell0.71639519
106* MP0002082_postnatal_lethality0.71638571
107* MP0010770_preweaning_lethality0.71638571
108MP0002229_neurodegeneration0.71055547
109MP0001324_abnormal_eye_pigmentation0.70814980
110MP0008872_abnormal_physiological_respon0.70720409
111MP0003303_peritoneal_inflammation0.70712172
112MP0009250_abnormal_appendicular_skeleto0.70262037
113* MP0010768_mortality/aging0.69925730
114MP0003633_abnormal_nervous_system0.68702580
115MP0003221_abnormal_cardiomyocyte_apopto0.68549774
116* MP0010769_abnormal_survival0.68489587
117MP0003567_abnormal_fetal_cardiomyocyte0.67283590
118MP0002177_abnormal_outer_ear0.65693852
119MP0001943_abnormal_respiration0.65240266
120MP0001299_abnormal_eye_distance/0.65152661
121MP0002938_white_spotting0.64760434

Predicted human phenotypes

RankGene SetZ-score
1Amyotrophic lateral sclerosis (HP:0007354)4.70954674
2Limb dystonia (HP:0002451)4.21932854
3Mutism (HP:0002300)4.10135506
4Drooling (HP:0002307)3.83380452
5Excessive salivation (HP:0003781)3.83380452
6Volvulus (HP:0002580)3.82077035
7Hepatoblastoma (HP:0002884)3.72922991
8Abnormality of the corticospinal tract (HP:0002492)3.59940249
9Akinesia (HP:0002304)3.43773389
10Epileptic encephalopathy (HP:0200134)3.38686071
11Inappropriate behavior (HP:0000719)3.35768779
12Supranuclear gaze palsy (HP:0000605)3.32961228
13Myokymia (HP:0002411)3.30234657
14Hypoplasia of the brainstem (HP:0002365)3.27147909
15Aplasia/Hypoplasia of the brainstem (HP:0007362)3.27147909
16Broad-based gait (HP:0002136)3.18041749
17Focal seizures (HP:0007359)3.17232896
18Hyperventilation (HP:0002883)3.15176031
19Ankle clonus (HP:0011448)3.14218232
20Polyphagia (HP:0002591)3.10467980
21Cortical dysplasia (HP:0002539)3.00397944
22* Pachygyria (HP:0001302)2.91472201
23Insidious onset (HP:0003587)2.88340705
24Termporal pattern (HP:0011008)2.88340705
25Focal motor seizures (HP:0011153)2.87158031
26Obstructive sleep apnea (HP:0002870)2.83528191
27Poor eye contact (HP:0000817)2.80261033
28Hypsarrhythmia (HP:0002521)2.78968593
29EEG with generalized epileptiform discharges (HP:0011198)2.76783134
30Papilledema (HP:0001085)2.74030187
31Visual hallucinations (HP:0002367)2.71253208
32Atrophy/Degeneration involving motor neurons (HP:0007373)2.68901549
33Epileptiform EEG discharges (HP:0011182)2.67643460
34Agitation (HP:0000713)2.66576668
35Protruding tongue (HP:0010808)2.64553637
36Amblyopia (HP:0000646)2.61820563
37Progressive inability to walk (HP:0002505)2.61811255
38Apathy (HP:0000741)2.61049445
39Shoulder girdle muscle weakness (HP:0003547)2.60624114
40Disinhibition (HP:0000734)2.59915450
41Progressive cerebellar ataxia (HP:0002073)2.55110665
42Neoplasm of the adrenal cortex (HP:0100641)2.53773332
43Megalencephaly (HP:0001355)2.52582408
44Urinary urgency (HP:0000012)2.51036034
45* Lissencephaly (HP:0001339)2.49727379
46Exotropia (HP:0000577)2.48294524
47Morphological abnormality of the pyramidal tract (HP:0002062)2.45839231
48Abnormality of salivation (HP:0100755)2.45623099
49Cerebral inclusion bodies (HP:0100314)2.41661713
50Sacral dimple (HP:0000960)2.41214335
51Neurofibrillary tangles (HP:0002185)2.40810207
52Diminished motivation (HP:0000745)2.39328684
53Retinal dysplasia (HP:0007973)2.38270438
54Long clavicles (HP:0000890)2.36273431
55Genetic anticipation (HP:0003743)2.34344968
56Pendular nystagmus (HP:0012043)2.34037291
57Impaired social interactions (HP:0000735)2.33497732
58Abnormal social behavior (HP:0012433)2.33497732
59Fetal akinesia sequence (HP:0001989)2.32966543
60Hemiparesis (HP:0001269)2.32406150
61Inability to walk (HP:0002540)2.31215052
62Stereotypic behavior (HP:0000733)2.29886454
63Dialeptic seizures (HP:0011146)2.29052134
64True hermaphroditism (HP:0010459)2.27260508
65Tented upper lip vermilion (HP:0010804)2.27085246
66Urinary bladder sphincter dysfunction (HP:0002839)2.25492595
67Hypoplasia of the corpus callosum (HP:0002079)2.25484879
68Optic nerve hypoplasia (HP:0000609)2.24561554
69Spastic gait (HP:0002064)2.23531366
70Pancreatic cysts (HP:0001737)2.23198617
71Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.22670002
72Generalized tonic-clonic seizures (HP:0002069)2.22506960
73Nephronophthisis (HP:0000090)2.22006632
74Atonic seizures (HP:0010819)2.20945503
75Papillary thyroid carcinoma (HP:0002895)2.19967989
76Absent speech (HP:0001344)2.19284853
77Sporadic (HP:0003745)2.18680019
78Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.15991031
79Sleep apnea (HP:0010535)2.14621503
80Medial flaring of the eyebrow (HP:0010747)2.14272463
81Gait imbalance (HP:0002141)2.13314866
82Open mouth (HP:0000194)2.12673076
83Aplasia/Hypoplasia of the sternum (HP:0006714)2.12314968
84Pancreatic fibrosis (HP:0100732)2.12112454
85Germ cell neoplasia (HP:0100728)2.11827186
86Renal hypoplasia (HP:0000089)2.10923548
87Febrile seizures (HP:0002373)2.10712799
88Narrow forehead (HP:0000341)2.10200918
89Aqueductal stenosis (HP:0002410)2.08255718
90Abnormality of the astrocytes (HP:0100707)2.07981163
91Astrocytoma (HP:0009592)2.07981163
92Abnormality of midbrain morphology (HP:0002418)2.07248375
93Molar tooth sign on MRI (HP:0002419)2.07248375
94Elfin facies (HP:0004428)2.06546959
95Impaired vibration sensation in the lower limbs (HP:0002166)2.06022738
96Abnormality of the lower motor neuron (HP:0002366)2.05850430
97Nephrogenic diabetes insipidus (HP:0009806)2.05547767
98Heterotopia (HP:0002282)2.01168638
99Abnormal eating behavior (HP:0100738)2.00801305
100Lower limb muscle weakness (HP:0007340)2.00499876
101Insomnia (HP:0100785)1.99856107
102Subacute progressive viral hepatitis (HP:0006572)1.99360312
103Abnormality of the labia minora (HP:0012880)1.98083127
104Hyperacusis (HP:0010780)1.97983349
105Ulnar claw (HP:0001178)1.97902172
106Patellar aplasia (HP:0006443)1.97770866
107Widely spaced teeth (HP:0000687)1.97539154
108Genital tract atresia (HP:0001827)1.97310968
109Polymicrogyria (HP:0002126)1.96554577
110Cupped ear (HP:0000378)1.95551051
111Intellectual disability, severe (HP:0010864)1.94820563
112Esotropia (HP:0000565)1.93428699
113Congenital primary aphakia (HP:0007707)1.92156609
114Vaginal atresia (HP:0000148)1.92068960
115Gastroesophageal reflux (HP:0002020)1.90506089
116Intestinal atresia (HP:0011100)1.90480304
117Abnormality of binocular vision (HP:0011514)1.90445206
118Diplopia (HP:0000651)1.90445206
119Shawl scrotum (HP:0000049)1.90213951
120Torticollis (HP:0000473)1.89868533
121Facial hemangioma (HP:0000329)1.89614875
122Autism (HP:0000717)1.87606626
123Abnormality of the renal medulla (HP:0100957)1.86422740
124Specific learning disability (HP:0001328)1.85784893
125Short 4th metacarpal (HP:0010044)1.84687344
126Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.84687344
127Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84236384
128Abnormality of the intervertebral disk (HP:0005108)1.83663114
129Overriding aorta (HP:0002623)1.83404229
130Hip dysplasia (HP:0001385)1.83045967
131Cutaneous finger syndactyly (HP:0010554)1.82340233
132Spastic tetraplegia (HP:0002510)1.79956664
133Aplasia/Hypoplasia of the patella (HP:0006498)1.79922213
134Truncal ataxia (HP:0002078)1.79128915
135Large earlobe (HP:0009748)1.78903377
136Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78693720
137Degeneration of the lateral corticospinal tracts (HP:0002314)1.78693720
138Gaze-evoked nystagmus (HP:0000640)1.78164729
139Absence seizures (HP:0002121)1.77870816
140Oligodactyly (hands) (HP:0001180)1.77110743
141Type II lissencephaly (HP:0007260)1.76505655
142Postaxial hand polydactyly (HP:0001162)1.73182196

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* MARK18.03742354
2DYRK23.75057501
3MAPK133.09552957
4NTRK22.88614335
5ERBB32.84173227
6MAP3K42.55249062
7CASK2.44184157
8MAP2K72.43929203
9SIK22.43549226
10MAP3K92.40141759
11PHKG12.28381841
12PHKG22.28381841
13MINK12.26847021
14MAP4K22.03621857
15KSR11.89101777
16NTRK31.88552975
17EPHB21.84473756
18DAPK21.81546130
19FRK1.75071494
20LATS21.67589547
21CSNK1G21.62629141
22PAK61.52763125
23EPHA41.49599930
24TRIM281.39504205
25TNIK1.34257382
26UHMK11.31687816
27LIMK11.31687274
28CSNK1G31.30552723
29PKN11.26668623
30CSNK1A1L1.20975706
31PNCK1.16701631
32MAP3K61.15166887
33* CDK51.13096855
34MAP2K41.12849914
35DYRK1A1.09398700
36MARK21.09209840
37PINK11.06445657
38FGFR21.01053723
39WNK30.99309895
40TYRO30.98203463
41RPS6KA20.97216197
42PRKCZ0.92253591
43PLK20.89725282
44CSNK1G10.88486314
45BCR0.86209344
46TAF10.83541402
47BMPR1B0.82576158
48PRPF4B0.80551751
49INSRR0.78389756
50CAMKK10.77996295
51SGK4940.77818903
52SGK2230.77818903
53DAPK10.77490828
54PRKCG0.77224341
55DYRK30.77021760
56CDK180.76262680
57TAOK10.75070946
58PAK30.75026933
59STK110.75008160
60SGK20.73537134
61RET0.73519560
62CDK150.72930990
63CDK140.72571209
64CCNB10.69610156
65ADRBK20.69526627
66CDK11A0.62698777
67MAPK120.62463081
68EIF2AK20.58626949
69ICK0.57839418
70CAMK1G0.57557217
71MKNK20.54718073
72NUAK10.52030926
73CAMK2A0.49645139
74GRK10.48451837
75SGK30.45722954
76YES10.43842348
77* MAPK90.43381740
78ROCK10.42647172
79CSNK1D0.42328527
80DYRK1B0.42058187
81SIK30.40859450
82FYN0.40692017
83AKT30.40596337
84PRKCE0.39780434
85PRKCI0.39675213
86NLK0.39301922
87ILK0.38397278
88SCYL20.38305310
89SGK10.38230132
90CAMK2B0.37952164
91MAP2K60.37030684
92PRKAA10.36137318
93* MAPK80.35264329
94NTRK10.34573744
95PDGFRA0.34074991
96KSR20.33733469
97CDK30.33675370
98CAMK40.33670042
99ALK0.33479177
100ERBB20.33381775
101PRKACB0.33104587
102GRK50.32342030
103CSNK1A10.32329829
104RPS6KB10.31132520
105* PRKACA0.30809633
106EPHA30.29241280
107FGR0.27868041
108* GSK3B0.27850651
109SRPK10.26958521
110MAP3K120.26361161
111MKNK10.26263900
112ROCK20.25951132
113TESK10.25420877
114* PRKG10.25194224
115MAP3K20.24966415
116BRD40.24331914
117ADRBK10.24074009
118ERBB40.23186925
119CSNK1E0.22404495
120* RPS6KA30.22199473
121GSK3A0.21983898
122VRK10.21402446
123PRKCH0.21021751
124* PRKCB0.19960014
125* PRKDC0.18959848
126PRKD30.18705578
127CAMK10.18513946

Predicted pathways (KEGG)

RankGene SetZ-score
1Axon guidance_Homo sapiens_hsa043603.04563090
2Nicotine addiction_Homo sapiens_hsa050332.93104815
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49793121
4Dopaminergic synapse_Homo sapiens_hsa047282.22007962
5Circadian entrainment_Homo sapiens_hsa047132.21714336
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.21572719
7Synaptic vesicle cycle_Homo sapiens_hsa047212.19159515
8GABAergic synapse_Homo sapiens_hsa047272.18930287
9Glutamatergic synapse_Homo sapiens_hsa047242.18595956
10Morphine addiction_Homo sapiens_hsa050322.05005744
11Olfactory transduction_Homo sapiens_hsa047402.03786260
12Endometrial cancer_Homo sapiens_hsa052132.03424039
13Cholinergic synapse_Homo sapiens_hsa047251.98810428
14Colorectal cancer_Homo sapiens_hsa052101.96041232
15Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.82895305
16Serotonergic synapse_Homo sapiens_hsa047261.79480911
17Long-term potentiation_Homo sapiens_hsa047201.78082486
18Gap junction_Homo sapiens_hsa045401.66770564
19ErbB signaling pathway_Homo sapiens_hsa040121.64583924
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62647556
21Cocaine addiction_Homo sapiens_hsa050301.57764202
22Long-term depression_Homo sapiens_hsa047301.56735906
23Taste transduction_Homo sapiens_hsa047421.48437341
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.47209188
25Amphetamine addiction_Homo sapiens_hsa050311.46478469
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43735237
27Renal cell carcinoma_Homo sapiens_hsa052111.37022744
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35324174
29Type II diabetes mellitus_Homo sapiens_hsa049301.33072398
30Oxytocin signaling pathway_Homo sapiens_hsa049211.32855928
31Glioma_Homo sapiens_hsa052141.32672071
32Renin secretion_Homo sapiens_hsa049241.32136136
33Basal transcription factors_Homo sapiens_hsa030221.30947578
34Estrogen signaling pathway_Homo sapiens_hsa049151.27009582
35Insulin secretion_Homo sapiens_hsa049111.23933106
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21477693
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21319856
38Melanogenesis_Homo sapiens_hsa049161.15452804
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.14914052
40Viral myocarditis_Homo sapiens_hsa054161.14636406
41Steroid biosynthesis_Homo sapiens_hsa001001.13806038
42GnRH signaling pathway_Homo sapiens_hsa049121.11814623
43Wnt signaling pathway_Homo sapiens_hsa043101.09384565
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08368301
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06696549
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.04165300
47Salivary secretion_Homo sapiens_hsa049701.03007884
48Basal cell carcinoma_Homo sapiens_hsa052171.02331959
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01303562
50Gastric acid secretion_Homo sapiens_hsa049710.98594621
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97648153
52Cardiac muscle contraction_Homo sapiens_hsa042600.97439221
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95344219
54Alcoholism_Homo sapiens_hsa050340.92714605
55Hedgehog signaling pathway_Homo sapiens_hsa043400.90073654
56mTOR signaling pathway_Homo sapiens_hsa041500.89846878
57Hippo signaling pathway_Homo sapiens_hsa043900.89150018
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87626321
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87227362
60MAPK signaling pathway_Homo sapiens_hsa040100.86325960
61Choline metabolism in cancer_Homo sapiens_hsa052310.86165654
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86010026
63Phototransduction_Homo sapiens_hsa047440.85815369
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85251226
65Ras signaling pathway_Homo sapiens_hsa040140.82585375
66cAMP signaling pathway_Homo sapiens_hsa040240.82456815
67VEGF signaling pathway_Homo sapiens_hsa043700.80725954
68Non-small cell lung cancer_Homo sapiens_hsa052230.80363055
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78982989
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78939693
71Oocyte meiosis_Homo sapiens_hsa041140.78015212
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77395722
73Insulin signaling pathway_Homo sapiens_hsa049100.77081704
74Ether lipid metabolism_Homo sapiens_hsa005650.75474786
75Linoleic acid metabolism_Homo sapiens_hsa005910.72868520
76Prolactin signaling pathway_Homo sapiens_hsa049170.72566587
77Calcium signaling pathway_Homo sapiens_hsa040200.72375207
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71997261
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71737350
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.71589734
81Pancreatic cancer_Homo sapiens_hsa052120.71066051
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69005845
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68111400
84Butanoate metabolism_Homo sapiens_hsa006500.67082775
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66906657
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.66810028
87Rap1 signaling pathway_Homo sapiens_hsa040150.66296255
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65436455
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63942943
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60671433
91Melanoma_Homo sapiens_hsa052180.60352982
92Dorso-ventral axis formation_Homo sapiens_hsa043200.59292102
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58593217
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58527977
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58449488
96Chronic myeloid leukemia_Homo sapiens_hsa052200.58344142
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57718541
98mRNA surveillance pathway_Homo sapiens_hsa030150.57007833
99AMPK signaling pathway_Homo sapiens_hsa041520.56782680
100Endocytosis_Homo sapiens_hsa041440.55732541
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55648785
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53660517
103Tryptophan metabolism_Homo sapiens_hsa003800.53178612
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52700257
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52111279
106Propanoate metabolism_Homo sapiens_hsa006400.51614889
107Ovarian steroidogenesis_Homo sapiens_hsa049130.51329360
108Fatty acid biosynthesis_Homo sapiens_hsa000610.50005967
109Tight junction_Homo sapiens_hsa045300.49782934
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49530966
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48937431
112Prion diseases_Homo sapiens_hsa050200.47894259
113T cell receptor signaling pathway_Homo sapiens_hsa046600.47764912
114Dilated cardiomyopathy_Homo sapiens_hsa054140.46197452
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46186814
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46139961
117MicroRNAs in cancer_Homo sapiens_hsa052060.44701117
118FoxO signaling pathway_Homo sapiens_hsa040680.44661515
119Alzheimers disease_Homo sapiens_hsa050100.44627222
120Parkinsons disease_Homo sapiens_hsa050120.43080617
121Circadian rhythm_Homo sapiens_hsa047100.42813558
122Collecting duct acid secretion_Homo sapiens_hsa049660.40905854
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38281668
124Nitrogen metabolism_Homo sapiens_hsa009100.37484170
125Caffeine metabolism_Homo sapiens_hsa002320.36146738
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35570163
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.35492579

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