DCTN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of dendrite morphogenesis (GO:0050774)4.68416291
2neurofilament cytoskeleton organization (GO:0060052)4.64130160
3inositol phosphate catabolic process (GO:0071545)4.46008540
4presynaptic membrane assembly (GO:0097105)4.10595652
5negative regulation of calcium ion transport into cytosol (GO:0010523)3.93936771
6presynaptic membrane organization (GO:0097090)3.70370438
7nucleobase catabolic process (GO:0046113)3.67141524
8regulation of pigment cell differentiation (GO:0050932)3.64523124
9phosphorylated carbohydrate dephosphorylation (GO:0046838)3.56056611
10inositol phosphate dephosphorylation (GO:0046855)3.56056611
11peripheral nervous system neuron development (GO:0048935)3.51065996
12postsynaptic membrane organization (GO:0001941)3.48352337
13negative regulation of dendrite development (GO:2000171)3.43586778
14axonal fasciculation (GO:0007413)3.38166972
15cerebral cortex radially oriented cell migration (GO:0021799)3.33625106
16regulation of synaptic vesicle exocytosis (GO:2000300)3.29567962
17detection of temperature stimulus involved in sensory perception (GO:0050961)3.28893769
18detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.28893769
19neuronal action potential propagation (GO:0019227)3.28709496
20positive regulation of dendritic spine morphogenesis (GO:0061003)3.28225476
21synaptic vesicle maturation (GO:0016188)3.26155387
22neuron cell-cell adhesion (GO:0007158)3.24075011
23innervation (GO:0060384)3.20150332
24negative regulation of membrane potential (GO:0045837)3.14961199
25cell migration in hindbrain (GO:0021535)3.10284018
26detection of temperature stimulus (GO:0016048)3.09257289
27regulation of cell maturation (GO:1903429)3.06451408
28membrane assembly (GO:0071709)3.06447758
29mechanosensory behavior (GO:0007638)3.06346384
30auditory behavior (GO:0031223)3.05256974
31glutamate secretion (GO:0014047)3.04053227
32negative regulation of synaptic transmission, GABAergic (GO:0032229)3.00836218
33nuclear pore complex assembly (GO:0051292)3.00108183
34apical protein localization (GO:0045176)2.97734684
35nonmotile primary cilium assembly (GO:0035058)2.95740920
36synaptic vesicle exocytosis (GO:0016079)2.95240440
37nuclear pore organization (GO:0006999)2.91991787
38sympathetic nervous system development (GO:0048485)2.90497207
39regulation of oxidative stress-induced neuron death (GO:1903203)2.90387799
40regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.89486949
41negative regulation of homotypic cell-cell adhesion (GO:0034111)2.87783560
42regulation of short-term neuronal synaptic plasticity (GO:0048172)2.87412050
43dendritic spine organization (GO:0097061)2.87033070
44myelin assembly (GO:0032288)2.82285021
45protein localization to synapse (GO:0035418)2.81329633
46establishment of mitochondrion localization (GO:0051654)2.79448568
47regulation of synaptic vesicle transport (GO:1902803)2.79117824
48calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.76489844
49regulation of dendritic spine morphogenesis (GO:0061001)2.76079504
50protein localization to cilium (GO:0061512)2.74680688
51inositol metabolic process (GO:0006020)2.72441278
52regulation of protein heterodimerization activity (GO:0043497)2.70851783
53regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.69204467
54negative regulation of neurotransmitter secretion (GO:0046929)2.67882830
55regulation of cAMP-dependent protein kinase activity (GO:2000479)2.65259742
56negative regulation of osteoblast proliferation (GO:0033689)2.64630493
57vocalization behavior (GO:0071625)2.63749166
58asymmetric protein localization (GO:0008105)2.63631132
59glomerulus development (GO:0032835)2.61513590
60sequestering of extracellular ligand from receptor (GO:0035581)2.61136324
61regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.59963437
62facial nerve structural organization (GO:0021612)2.58605370
63positive regulation of mitochondrial fission (GO:0090141)2.57198084
64negative regulation of neurological system process (GO:0031645)2.55855109
65membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.52246949
66regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.52153578
67bone remodeling (GO:0046849)2.51031428
68synaptic vesicle docking involved in exocytosis (GO:0016081)2.48397014
69intraciliary transport (GO:0042073)2.48036174
70regulation of synapse structural plasticity (GO:0051823)2.47616942
71dendrite development (GO:0016358)2.46447581
72regulation of cell communication by electrical coupling (GO:0010649)2.45983792
73hippocampus development (GO:0021766)2.45338316
74regulation of relaxation of muscle (GO:1901077)2.45155940
75enteric nervous system development (GO:0048484)2.44977542
76striatum development (GO:0021756)2.44713189
77axon extension (GO:0048675)2.44574970
78negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.44074771
79mechanoreceptor differentiation (GO:0042490)2.43867738
80regulation of neuronal synaptic plasticity (GO:0048168)2.40626429
81central nervous system neuron axonogenesis (GO:0021955)2.39327796
82dendritic spine morphogenesis (GO:0060997)2.38994918
83dendrite morphogenesis (GO:0048813)2.38769747
84olfactory bulb development (GO:0021772)2.38495314
85neurotransmitter-gated ion channel clustering (GO:0072578)2.37887137
86positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.37686210
87Golgi to endosome transport (GO:0006895)2.36203976
88organelle transport along microtubule (GO:0072384)2.36183821
89mitotic sister chromatid cohesion (GO:0007064)2.35097024
90brain morphogenesis (GO:0048854)2.33603843
91cranial nerve structural organization (GO:0021604)2.32317945
92regulation of glutamate receptor signaling pathway (GO:1900449)2.32241500
93neuronal action potential (GO:0019228)2.32227453
94cerebral cortex cell migration (GO:0021795)2.31660185
95negative regulation of cytosolic calcium ion concentration (GO:0051481)2.31551752
96regulation of platelet aggregation (GO:0090330)2.30749775
97COPI coating of Golgi vesicle (GO:0048205)2.30578901
98Golgi transport vesicle coating (GO:0048200)2.30578901
99axonogenesis (GO:0007409)2.30568126
100regulation of glycogen (starch) synthase activity (GO:2000465)2.30275585
101histone H2A acetylation (GO:0043968)2.29667086
102appendage development (GO:0048736)2.29608880
103limb development (GO:0060173)2.29608880
104retinal ganglion cell axon guidance (GO:0031290)2.29294832
105resolution of meiotic recombination intermediates (GO:0000712)2.28748437
106negative regulation of neurotransmitter transport (GO:0051589)2.28623598
107negative chemotaxis (GO:0050919)2.28379297
108long-chain fatty acid biosynthetic process (GO:0042759)2.27187121
109polyol catabolic process (GO:0046174)2.26226947
110axon development (GO:0061564)2.25719594
111central nervous system projection neuron axonogenesis (GO:0021952)2.25264080
112neurotransmitter uptake (GO:0001504)2.24744956
113regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.24555664
114limb bud formation (GO:0060174)2.23676457
115response to auditory stimulus (GO:0010996)2.22251423
116regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.21941885
117membrane depolarization during action potential (GO:0086010)2.21870295
118neuromuscular synaptic transmission (GO:0007274)2.20440920
119positive regulation of synapse assembly (GO:0051965)2.19363689
120endoplasmic reticulum organization (GO:0007029)2.19271474
121regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.18917752
122pyrimidine nucleobase catabolic process (GO:0006208)2.18583999
123C4-dicarboxylate transport (GO:0015740)2.17875810
124pore complex assembly (GO:0046931)2.17824272
125neuron projection extension (GO:1990138)2.17561277
126regulation of synaptic transmission, GABAergic (GO:0032228)2.16954617
127adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.16602957
128neuron recognition (GO:0008038)2.16392155
129synapse assembly (GO:0007416)2.16383920
130cytoskeleton-dependent intracellular transport (GO:0030705)2.16016834
131regulation of neurotransmitter secretion (GO:0046928)2.15819687
132regulation of dendritic spine development (GO:0060998)2.15481209
133microtubule-based transport (GO:0010970)2.15439936
134regulation of excitatory postsynaptic membrane potential (GO:0060079)2.14959560
135regulation of respiratory system process (GO:0044065)2.13958450
136negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.13914457
137ganglion development (GO:0061548)2.13658100
138positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.13258654
139regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.12690518
140fatty acid elongation (GO:0030497)2.12606581
141regulation of long-term neuronal synaptic plasticity (GO:0048169)2.12598419
142mitochondrial calcium ion homeostasis (GO:0051560)2.12541748
143positive regulation of dendritic spine development (GO:0060999)2.12419409
144cellular response to prostaglandin stimulus (GO:0071379)2.12418705
145mitochondrion transport along microtubule (GO:0047497)2.12411085
146establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.12411085
147negative regulation of axon extension involved in axon guidance (GO:0048843)2.11884971
148neural tube formation (GO:0001841)2.10972242
149regulation of dendrite morphogenesis (GO:0048814)2.10039804
150positive regulation of bone remodeling (GO:0046852)2.09787635
151positive regulation of bone resorption (GO:0045780)2.09787635
152gastrulation with mouth forming second (GO:0001702)2.09719552
153negative regulation of glycogen biosynthetic process (GO:0045719)2.09640663
154negative regulation of fatty acid transport (GO:2000192)2.09611563
155regulation of NFAT protein import into nucleus (GO:0051532)2.09579377
156positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.09410773
157synapse organization (GO:0050808)2.08865287
158COPII vesicle coating (GO:0048208)2.07459984
159regulation of male gonad development (GO:2000018)2.06377362
160regulation of DNA endoreduplication (GO:0032875)2.05115808
161regulation of synapse assembly (GO:0051963)2.04710410
162positive regulation of dendrite morphogenesis (GO:0050775)2.03737214
163cullin deneddylation (GO:0010388)2.02891734
164regulation of cilium movement (GO:0003352)2.01322747
165positive regulation of male gonad development (GO:2000020)1.97329731
166ephrin receptor signaling pathway (GO:0048013)1.96204504

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.23018410
2GBX2_23144817_ChIP-Seq_PC3_Human3.83615505
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.09987542
4AR_21572438_ChIP-Seq_LNCaP_Human2.64359876
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61657500
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.49137036
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.46657612
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.44272801
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.32629424
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24615476
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24615476
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21703017
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21142219
14TAF15_26573619_Chip-Seq_HEK293_Human2.19838827
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15300022
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14592907
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10310161
18PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.08056426
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.05003279
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03525117
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.99387905
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96108095
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.94435013
24P300_19829295_ChIP-Seq_ESCs_Human1.93177764
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92458585
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.91846547
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.91048276
28SMAD4_21799915_ChIP-Seq_A2780_Human1.90978223
29ZNF274_21170338_ChIP-Seq_K562_Hela1.89020511
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87881767
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87171616
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86444422
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86128532
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85464792
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.79758920
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78153214
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76957041
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.76229593
39IGF1R_20145208_ChIP-Seq_DFB_Human1.75044976
40* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73517527
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72543129
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71404540
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69228331
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.66342419
45RNF2_27304074_Chip-Seq_NSC_Mouse1.65463329
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64357064
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.58926199
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58689305
49AHR_22903824_ChIP-Seq_MCF-7_Human1.56285333
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55887283
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54434373
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.53628617
53TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.52931567
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52903889
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49414943
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.49309724
57* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.48587856
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48508458
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46890589
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44235377
61CBP_20019798_ChIP-Seq_JUKART_Human1.43700405
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43700405
63RXR_22108803_ChIP-Seq_LS180_Human1.42271587
64AR_25329375_ChIP-Seq_VCAP_Human1.39415264
65* STAT3_23295773_ChIP-Seq_U87_Human1.37759748
66HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.37753496
67NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37575212
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37575212
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33584822
70REST_21632747_ChIP-Seq_MESCs_Mouse1.33361585
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30443455
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30348205
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29534320
74STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.29379936
75WT1_19549856_ChIP-ChIP_CCG9911_Human1.26812470
76ER_23166858_ChIP-Seq_MCF-7_Human1.26081380
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.24866466
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24829307
79TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24534298
80TP53_18474530_ChIP-ChIP_U2OS_Human1.24465603
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23302169
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23024369
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23024369
84FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21745576
85FUS_26573619_Chip-Seq_HEK293_Human1.20799096
86TCF4_23295773_ChIP-Seq_U87_Human1.20395911
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.16842253
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.16214810
89BCAT_22108803_ChIP-Seq_LS180_Human1.15341496
90* PRDM14_20953172_ChIP-Seq_ESCs_Human1.15309373
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14744275
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14680971
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.14529118
94VDR_22108803_ChIP-Seq_LS180_Human1.14033302
95ESR1_20079471_ChIP-ChIP_T-47D_Human1.13309005
96SOX2_21211035_ChIP-Seq_LN229_Gbm1.13209325
97E2F1_18555785_Chip-Seq_ESCs_Mouse1.12641716
98JUN_21703547_ChIP-Seq_K562_Human1.12383329
99RUNX2_22187159_ChIP-Seq_PCA_Human1.12325349
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12177508
101TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11181921
102FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10844034
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.09306025
104* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09139790
105EP300_21415370_ChIP-Seq_HL-1_Mouse1.08854339
106YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08217307
107* ELK1_19687146_ChIP-ChIP_HELA_Human1.08203453
108STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07981496
109NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06067890
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05699641
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04527238
112IRF1_19129219_ChIP-ChIP_H3396_Human1.03872912
113EWS_26573619_Chip-Seq_HEK293_Human1.03667809
114* SOX9_26525672_Chip-Seq_HEART_Mouse1.03263915
115CMYC_18555785_Chip-Seq_ESCs_Mouse1.03119360
116FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03037088
117REST_18959480_ChIP-ChIP_MESCs_Mouse1.02483221
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02168391
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01963798
120MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01771513
121TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01582863
122TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01547511
123VDR_24787735_ChIP-Seq_THP-1_Human1.00968301
124P53_22387025_ChIP-Seq_ESCs_Mouse1.00114428
125SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98976705
126TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98375326
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97396529
128CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97120633
129POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96690540
130PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96226942
131POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95983041
132SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95913354
133FLI1_27457419_Chip-Seq_LIVER_Mouse0.95727593
134RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94454137
135DROSHA_22980978_ChIP-Seq_HELA_Human0.93948229
136KDM2B_26808549_Chip-Seq_REH_Human0.93220140
137AR_19668381_ChIP-Seq_PC3_Human0.92700878

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception3.65391567
2MP0001348_abnormal_lacrimal_gland3.28332136
3MP0004270_analgesia3.15858495
4MP0004858_abnormal_nervous_system3.13339248
5MP0004859_abnormal_synaptic_plasticity3.09961446
6MP0003880_abnormal_central_pattern3.03122412
7MP0000372_irregular_coat_pigmentation2.93835262
8MP0001968_abnormal_touch/_nociception2.80310799
9MP0001188_hyperpigmentation2.56826572
10MP0006276_abnormal_autonomic_nervous2.51815355
11MP0002736_abnormal_nociception_after2.51117950
12MP0001529_abnormal_vocalization2.45753091
13MP0005171_absent_coat_pigmentation2.42462616
14MP0002734_abnormal_mechanical_nocicepti2.40671123
15MP0009046_muscle_twitch2.28419651
16MP0002751_abnormal_autonomic_nervous2.26638994
17MP0003635_abnormal_synaptic_transmissio2.15353980
18MP0000778_abnormal_nervous_system2.06706342
19MP0001986_abnormal_taste_sensitivity2.02019901
20MP0002822_catalepsy2.00512330
21MP0005248_abnormal_Harderian_gland1.97309489
22MP0005646_abnormal_pituitary_gland1.94329903
23MP0002272_abnormal_nervous_system1.93004700
24MP0002102_abnormal_ear_morphology1.92069941
25MP0009745_abnormal_behavioral_response1.86460196
26MP0005187_abnormal_penis_morphology1.81258661
27MP0002184_abnormal_innervation1.79613180
28MP0002067_abnormal_sensory_capabilities1.78742547
29MP0001486_abnormal_startle_reflex1.78556578
30MP0004885_abnormal_endolymph1.72294501
31MP0002063_abnormal_learning/memory/cond1.72143615
32MP0002064_seizures1.66699229
33MP0000015_abnormal_ear_pigmentation1.65503552
34MP0002733_abnormal_thermal_nociception1.59787217
35MP0001970_abnormal_pain_threshold1.56778004
36MP0003950_abnormal_plasma_membrane1.56101946
37MP0002572_abnormal_emotion/affect_behav1.52435300
38MP0009780_abnormal_chondrocyte_physiolo1.51360792
39MP0004215_abnormal_myocardial_fiber1.49770678
40MP0004147_increased_porphyrin_level1.47665764
41MP0004811_abnormal_neuron_physiology1.46295960
42MP0008569_lethality_at_weaning1.45745346
43MP0003787_abnormal_imprinting1.44615842
44MP0003879_abnormal_hair_cell1.43213526
45MP0000955_abnormal_spinal_cord1.42589892
46MP0005409_darkened_coat_color1.41552055
47MP0002009_preneoplasia1.41478480
48MP0000920_abnormal_myelination1.40334959
49MP0003221_abnormal_cardiomyocyte_apopto1.39833003
50MP0001984_abnormal_olfaction1.33086115
51MP0002233_abnormal_nose_morphology1.31258065
52MP0008057_abnormal_DNA_replication1.30052347
53MP0001963_abnormal_hearing_physiology1.28643601
54MP0001177_atelectasis1.27443391
55MP0003937_abnormal_limbs/digits/tail_de1.27048090
56MP0002882_abnormal_neuron_morphology1.24594473
57MP0002876_abnormal_thyroid_physiology1.24377866
58MP0000534_abnormal_ureter_morphology1.21829041
59MP0003121_genomic_imprinting1.21742499
60MP0009697_abnormal_copulation1.21423111
61MP0008789_abnormal_olfactory_epithelium1.21170007
62MP0003942_abnormal_urinary_system1.20948201
63MP0004084_abnormal_cardiac_muscle1.20891802
64MP0003861_abnormal_nervous_system1.20634063
65MP0008877_abnormal_DNA_methylation1.19944038
66MP0002557_abnormal_social/conspecific_i1.19557849
67MP0004233_abnormal_muscle_weight1.19539176
68MP0000647_abnormal_sebaceous_gland1.17198526
69MP0003755_abnormal_palate_morphology1.17090821
70MP0003122_maternal_imprinting1.17079244
71MP0005503_abnormal_tendon_morphology1.16795770
72MP0005408_hypopigmentation1.15622287
73MP0001905_abnormal_dopamine_level1.15045298
74MP0003935_abnormal_craniofacial_develop1.13269088
75MP0001502_abnormal_circadian_rhythm1.11771937
76MP0000631_abnormal_neuroendocrine_gland1.10303908
77MP0004197_abnormal_fetal_growth/weight/1.10165748
78MP0005623_abnormal_meninges_morphology1.09759368
79MP0000681_abnormal_thyroid_gland1.08303125
80MP0010386_abnormal_urinary_bladder1.07582257
81MP0009250_abnormal_appendicular_skeleto1.05862468
82MP0005645_abnormal_hypothalamus_physiol1.05679626
83MP0008058_abnormal_DNA_repair1.05390329
84MP0009703_decreased_birth_body1.05307278
85MP0002752_abnormal_somatic_nervous1.04434164
86MP0004134_abnormal_chest_morphology1.03901420
87MP0004742_abnormal_vestibular_system1.03532778
88MP0003634_abnormal_glial_cell1.02188480
89MP0006072_abnormal_retinal_apoptosis1.02160775
90MP0005499_abnormal_olfactory_system1.01483114
91MP0005394_taste/olfaction_phenotype1.01483114
92MP0001485_abnormal_pinna_reflex1.00652758
93MP0002177_abnormal_outer_ear1.00501365
94MP0001299_abnormal_eye_distance/1.00316657
95MP0002229_neurodegeneration0.99786723
96MP0000013_abnormal_adipose_tissue0.98883841
97MP0005386_behavior/neurological_phenoty0.96951620
98MP0004924_abnormal_behavior0.96951620
99MP0004142_abnormal_muscle_tone0.93170295
100MP0002081_perinatal_lethality0.92952999
101MP0003890_abnormal_embryonic-extraembry0.92726275
102MP0003119_abnormal_digestive_system0.91079505
103MP0002066_abnormal_motor_capabilities/c0.88829850
104MP0000751_myopathy0.88189821
105MP0004145_abnormal_muscle_electrophysio0.87900571
106MP0000026_abnormal_inner_ear0.87183868
107MP0000049_abnormal_middle_ear0.86572016
108MP0002909_abnormal_adrenal_gland0.85048937
109MP0005391_vision/eye_phenotype0.84601303
110MP0004782_abnormal_surfactant_physiolog0.84314929
111MP0002084_abnormal_developmental_patter0.82624569
112MP0000569_abnormal_digit_pigmentation0.82216862
113MP0000427_abnormal_hair_cycle0.82105896
114MP0001849_ear_inflammation0.81908586
115MP0004085_abnormal_heartbeat0.81283101
116MP0003633_abnormal_nervous_system0.80909613
117MP0003868_abnormal_feces_composition0.80784668
118MP0002697_abnormal_eye_size0.80721390
119MP0008775_abnormal_heart_ventricle0.79007861
120MP0005367_renal/urinary_system_phenotyp0.78271744
121MP0000516_abnormal_urinary_system0.78271744
122MP0001440_abnormal_grooming_behavior0.78227383
123MP0003385_abnormal_body_wall0.77643444
124MP0005551_abnormal_eye_electrophysiolog0.77480813
125MP0002638_abnormal_pupillary_reflex0.76471222
126MP0001542_abnormal_bone_strength0.75745153
127MP0010678_abnormal_skin_adnexa0.74411602
128MP0005423_abnormal_somatic_nervous0.73491653
129MP0001943_abnormal_respiration0.73300763
130MP0003567_abnormal_fetal_cardiomyocyte0.73156407
131MP0000383_abnormal_hair_follicle0.71928902
132MP0008995_early_reproductive_senescence0.71803700
133MP0003631_nervous_system_phenotype0.71666744
134MP0005075_abnormal_melanosome_morpholog0.70367770
135MP0001919_abnormal_reproductive_system0.70349781
136MP0002152_abnormal_brain_morphology0.70067281
137MP0002160_abnormal_reproductive_system0.68751963
138MP0002998_abnormal_bone_remodeling0.68647655
139MP0003183_abnormal_peptide_metabolism0.67731581
140MP0000749_muscle_degeneration0.67281240
141MP0003943_abnormal_hepatobiliary_system0.67049005
142MP0008438_abnormal_cutaneous_collagen0.64584468
143MP0002095_abnormal_skin_pigmentation0.64176688
144MP0005253_abnormal_eye_physiology0.58957081

Predicted human phenotypes

RankGene SetZ-score
1Febrile seizures (HP:0002373)4.31236667
2Hypothermia (HP:0002045)4.10253270
3Focal motor seizures (HP:0011153)3.89456590
4Volvulus (HP:0002580)3.63931233
5Drooling (HP:0002307)3.49045122
6Ulnar claw (HP:0001178)3.44008148
7Pheochromocytoma (HP:0002666)3.42769632
8Cortical dysplasia (HP:0002539)3.35831172
9Atonic seizures (HP:0010819)3.19321462
10Myokymia (HP:0002411)3.13663733
11Excessive salivation (HP:0003781)3.09874439
12Bradycardia (HP:0001662)3.03721824
13Neuroendocrine neoplasm (HP:0100634)3.02515685
14Epileptic encephalopathy (HP:0200134)2.96613737
15Action tremor (HP:0002345)2.82377903
16Gait imbalance (HP:0002141)2.76264234
17Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.75399866
18Fetal akinesia sequence (HP:0001989)2.74191626
19Submucous cleft hard palate (HP:0000176)2.68700602
20Abnormal hair whorl (HP:0010721)2.60602269
21Hyperventilation (HP:0002883)2.60131337
22Congenital primary aphakia (HP:0007707)2.59818840
23Medial flaring of the eyebrow (HP:0010747)2.57572028
24Syringomyelia (HP:0003396)2.56781885
25Spinal cord lesions (HP:0100561)2.56781885
26Asymmetry of the thorax (HP:0001555)2.54183715
27Urinary urgency (HP:0000012)2.53654352
28Progressive cerebellar ataxia (HP:0002073)2.53150435
29Absent speech (HP:0001344)2.49665499
30Thyroid carcinoma (HP:0002890)2.49484154
31Focal seizures (HP:0007359)2.47593198
32Abnormal auditory evoked potentials (HP:0006958)2.44178555
33Agitation (HP:0000713)2.43714520
34Failure to thrive in infancy (HP:0001531)2.41980881
35Thyroid-stimulating hormone excess (HP:0002925)2.40689700
36Absent frontal sinuses (HP:0002688)2.37654425
37Gaze-evoked nystagmus (HP:0000640)2.36473357
38Abnormality of the nasal septum (HP:0000419)2.32675965
39Shoulder girdle muscle weakness (HP:0003547)2.31876135
40Hepatoblastoma (HP:0002884)2.29011534
41Impaired vibration sensation in the lower limbs (HP:0002166)2.27815891
42Segmental peripheral demyelination/remyelination (HP:0003481)2.27648838
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.26228593
44Degeneration of the lateral corticospinal tracts (HP:0002314)2.26228593
45Broad-based gait (HP:0002136)2.25904073
46Decreased motor nerve conduction velocity (HP:0003431)2.23714640
47Rimmed vacuoles (HP:0003805)2.22901128
48Akinesia (HP:0002304)2.21634585
49Nephrogenic diabetes insipidus (HP:0009806)2.20754751
50Abnormality of the frontal sinuses (HP:0002687)2.18664817
51Long clavicles (HP:0000890)2.17964640
52Tubulointerstitial nephritis (HP:0001970)2.15450927
53Vertebral compression fractures (HP:0002953)2.13571947
54Abnormality of the musculature of the pelvis (HP:0001469)2.13310561
55Abnormality of the hip-girdle musculature (HP:0001445)2.13310561
56Hypercortisolism (HP:0001578)2.12679954
57Atrial fibrillation (HP:0005110)2.11813767
58Morphological abnormality of the middle ear (HP:0008609)2.11629250
59Retinal dysplasia (HP:0007973)2.11550950
60Genital tract atresia (HP:0001827)2.09958348
61Aqueductal stenosis (HP:0002410)2.09479977
62Polyphagia (HP:0002591)2.09438501
63Intestinal atresia (HP:0011100)2.08808113
64Fair hair (HP:0002286)2.06602418
65Heterochromia iridis (HP:0001100)2.06073914
66Vaginal atresia (HP:0000148)2.06036654
67Large earlobe (HP:0009748)2.05672675
68Absent eyebrow (HP:0002223)2.04650671
69Amyotrophic lateral sclerosis (HP:0007354)2.03304296
70Relative macrocephaly (HP:0004482)2.02140003
71Scanning speech (HP:0002168)2.00864506
72Poor coordination (HP:0002370)1.99026366
73Exercise-induced muscle cramps (HP:0003710)1.96961089
74Spastic tetraplegia (HP:0002510)1.96825522
75Pachygyria (HP:0001302)1.96250446
76Primary atrial arrhythmia (HP:0001692)1.95988524
77Stomach cancer (HP:0012126)1.95699907
78Aplasia involving bones of the extremities (HP:0009825)1.95209139
79Aplasia involving bones of the upper limbs (HP:0009823)1.95209139
80Aplasia of the phalanges of the hand (HP:0009802)1.95209139
81EEG with generalized epileptiform discharges (HP:0011198)1.94883412
82Termporal pattern (HP:0011008)1.94253849
83Insidious onset (HP:0003587)1.94253849
84Ankle clonus (HP:0011448)1.94029419
85Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.93870909
86Selective tooth agenesis (HP:0001592)1.93830690
87Abnormality of incisor morphology (HP:0011063)1.93306505
88Hypsarrhythmia (HP:0002521)1.92354002
89Cutaneous finger syndactyly (HP:0010554)1.91467923
90Medulloblastoma (HP:0002885)1.89476572
91Spinal canal stenosis (HP:0003416)1.88876301
92Supranuclear gaze palsy (HP:0000605)1.88742025
93Abnormality of the corticospinal tract (HP:0002492)1.88142697
94Growth hormone excess (HP:0000845)1.87717401
95Steppage gait (HP:0003376)1.87629216
96Epileptiform EEG discharges (HP:0011182)1.87339613
97Lower limb muscle weakness (HP:0007340)1.85334631
98Truncal ataxia (HP:0002078)1.85225830
99Spastic gait (HP:0002064)1.84745355
100Short nail (HP:0001799)1.84382334
101Urinary bladder sphincter dysfunction (HP:0002839)1.80554038
102Sleep apnea (HP:0010535)1.80447976
103Neoplasm of the peripheral nervous system (HP:0100007)1.78037761
104Oligodontia (HP:0000677)1.77819083
105Aplasia/Hypoplasia of the lens (HP:0008063)1.77815990
106Spastic paraplegia (HP:0001258)1.76827280
107Papillary thyroid carcinoma (HP:0002895)1.76384068
108Limb dystonia (HP:0002451)1.75194614
109Supraventricular tachycardia (HP:0004755)1.75033070
110Hypoventilation (HP:0002791)1.74995192
111Abnormality of molar (HP:0011077)1.74912975
112Abnormality of molar morphology (HP:0011070)1.74912975
113Paraplegia (HP:0010550)1.74754822
114Foot dorsiflexor weakness (HP:0009027)1.74322023
115Midline defect of the nose (HP:0004122)1.73626604
116Genetic anticipation (HP:0003743)1.73072941
117Postaxial hand polydactyly (HP:0001162)1.73033893
118Specific learning disability (HP:0001328)1.72924828
119Narrow nasal bridge (HP:0000446)1.72763135
120Absence seizures (HP:0002121)1.72753149
121Decreased testicular size (HP:0008734)1.71769565
122Hypoplasia of the corpus callosum (HP:0002079)1.71197868
123Optic nerve hypoplasia (HP:0000609)1.69977402
124Abnormality of salivation (HP:0100755)1.69888185
125Renal cortical cysts (HP:0000803)1.69819950
126Exotropia (HP:0000577)1.69360060
127Postnatal microcephaly (HP:0005484)1.69126192
128Lissencephaly (HP:0001339)1.68972323
129Intellectual disability, moderate (HP:0002342)1.68222912
130Split foot (HP:0001839)1.68068638
131Blue irides (HP:0000635)1.67590706
132Cutaneous syndactyly (HP:0012725)1.67524928
133Supraventricular arrhythmia (HP:0005115)1.67488360
134Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.67242854
135Dialeptic seizures (HP:0011146)1.66871134
136Abnormality of permanent molar morphology (HP:0011071)1.65496233
137Abnormality of the dental root (HP:0006486)1.65496233
138Taurodontia (HP:0000679)1.65496233
139Limb-girdle muscle weakness (HP:0003325)1.65323891
140Progressive inability to walk (HP:0002505)1.65323177
141Hemiparesis (HP:0001269)1.65133414
142Short foot (HP:0001773)1.64719150
143Abnormality of the astrocytes (HP:0100707)1.64471432
144Astrocytoma (HP:0009592)1.64471432
145Downturned corners of mouth (HP:0002714)1.64182759
146Type II lissencephaly (HP:0007260)1.63944220
147Glioma (HP:0009733)1.63668885
148Broad foot (HP:0001769)1.63518939
149True hermaphroditism (HP:0010459)1.63452456
150Open mouth (HP:0000194)1.63448735
151Menstrual irregularities (HP:0000858)1.62662656
152Pelvic girdle muscle weakness (HP:0003749)1.62485992
153Atrophy/Degeneration involving motor neurons (HP:0007373)1.61255296
154Curly hair (HP:0002212)1.60540888
155Autoamputation (HP:0001218)1.60097146
156Decreased lacrimation (HP:0000633)1.59794099
157Poor suck (HP:0002033)1.59776342
158Hammertoe (HP:0001765)1.59710985
159Transitional cell carcinoma of the bladder (HP:0006740)1.59667944
160Generalized tonic-clonic seizures (HP:0002069)1.57665228
161Distal sensory impairment (HP:0002936)1.57606281
162Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.56567057
163Protruding tongue (HP:0010808)1.55999523
164Abnormality of the phalanges of the hallux (HP:0010057)1.55941714
165Aplasia/Hypoplasia of the brainstem (HP:0007362)1.55853181
166Hypoplasia of the brainstem (HP:0002365)1.55853181
167Tented upper lip vermilion (HP:0010804)1.55808982
168Bladder neoplasm (HP:0009725)1.54548151
169Bladder carcinoma (HP:0002862)1.54548151
170Aplasia/Hypoplasia of the sternum (HP:0006714)1.53258248
171Abnormality of dentin (HP:0010299)1.52750160
172Abnormal eating behavior (HP:0100738)1.52258267
173Narrow forehead (HP:0000341)1.52213111
174Complete atrioventricular canal defect (HP:0001674)1.51441043
175Micropenis (HP:0000054)1.50582806

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B5.30064338
2CASK4.67983459
3AKT33.09511919
4MAP2K72.76289265
5SGK22.63539273
6ERBB32.53522308
7SGK4942.45634810
8SGK2232.45634810
9SIK32.40221411
10YES12.26364693
11TRIM282.26353978
12PNCK2.24967316
13MARK12.14464133
14MUSK2.09176541
15NTRK32.07282820
16TNIK2.07042783
17MINK12.02084629
18WNK32.01941477
19BCR2.00355281
20MKNK21.93416801
21CAMKK21.92386385
22MAPK131.89471509
23SGK31.88529489
24MAP3K121.78687391
25MKNK11.76649532
26PLK21.69761479
27MAP3K61.64611076
28MAP3K41.50284724
29NTRK11.49940615
30BRD41.46999203
31DYRK31.44634251
32WEE11.42799970
33SRPK11.40431153
34MAP4K21.37328786
35UHMK11.35691961
36BMPR21.35451015
37CSNK1G11.31800536
38CDK81.26397022
39LIMK11.25837467
40CAMK1G1.25719589
41STK391.17172673
42EIF2AK31.13054263
43CAMKK11.05794314
44NEK91.05390538
45TSSK61.04983003
46NTRK21.02901933
47LMTK21.02165316
48TGFBR10.96477467
49ZAK0.94747594
50DYRK20.93771276
51PRKCE0.91743022
52BRSK20.88898001
53CDK50.88693703
54BMPR1B0.87085759
55CAMK1D0.86380149
56NEK60.86199064
57MAP3K140.85604783
58OXSR10.80604612
59NEK10.80151454
60RPS6KA40.80093811
61FGFR30.78247993
62CCNB10.77210116
63MET0.76086088
64ACVR1B0.75889648
65SCYL20.75440809
66PRKCG0.72897182
67GRK70.71182958
68PHKG10.70419699
69PHKG20.70419699
70DAPK20.69000207
71TRPM70.68643121
72PKN10.67294226
73OBSCN0.66732996
74FER0.65757042
75ERBB40.65601063
76PRKCH0.64817750
77CAMK2A0.64041909
78WNK10.63015807
79PDGFRA0.62139402
80STK240.61303379
81FGFR20.60590462
82PIK3CG0.60328318
83MAP2K40.59599232
84RPS6KA20.59101815
85LATS10.58920555
86PIK3CA0.58913353
87PAK60.58748360
88CSNK1G20.58333205
89NUAK10.57682679
90MATK0.56943835
91GRK50.55666254
92TTK0.55350187
93DYRK1A0.54583450
94PINK10.53341723
95TESK10.53166942
96EPHA40.52431279
97CSNK1A1L0.52189273
98SGK10.52036811
99PRKAA10.51684027
100CDK90.50315800
101EIF2AK20.49653451
102WNK40.48795780
103DYRK1B0.48275485
104ROCK20.47505110
105ROCK10.47423554
106RPS6KB10.47063648
107ADRBK10.46988007
108PRKD30.46544981
109ATM0.46308286
110MAP2K10.46133235
111STK30.45515653
112CDK140.45065292
113CAMK2B0.44923489
114STK38L0.44449358
115PLK30.44061416
116CDK150.43866045
117EIF2AK10.43045865
118CAMK2D0.42532230
119CDK30.42447491
120BRAF0.42058596
121BCKDK0.41924731
122CDK180.41717013
123CSNK1G30.41360467
124PDK20.41286934
125FRK0.40272721
126PLK10.40144092
127PAK30.39493760
128KSR10.39443916
129EEF2K0.39268664
130ADRBK20.38747196
131CSNK1D0.38091842
132ERBB20.37790378
133IRAK40.37328374
134EPHB20.36372560
135CHUK0.35989942
136PRKG10.35045453
137RET0.34909059
138CDK190.34468671
139RIPK40.34291166
140EPHA30.33884671
141CAMK40.32419113
142RPS6KL10.32093788
143RPS6KC10.32093788
144MAPK80.32016824
145MAPK100.31890126
146RPS6KA60.30745945

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.03102241
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.69278320
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.67092637
4Steroid biosynthesis_Homo sapiens_hsa001002.45217024
5Nicotine addiction_Homo sapiens_hsa050332.25338862
6Olfactory transduction_Homo sapiens_hsa047402.03646082
7Protein export_Homo sapiens_hsa030602.00131735
8Propanoate metabolism_Homo sapiens_hsa006401.87890695
9Non-homologous end-joining_Homo sapiens_hsa034501.86769362
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82806762
11Circadian entrainment_Homo sapiens_hsa047131.71086538
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67977012
13Collecting duct acid secretion_Homo sapiens_hsa049661.58215133
14Cholinergic synapse_Homo sapiens_hsa047251.57358456
15Glutamatergic synapse_Homo sapiens_hsa047241.56176925
16Axon guidance_Homo sapiens_hsa043601.55865473
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.55453335
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.53756466
19Butanoate metabolism_Homo sapiens_hsa006501.52934593
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.51550800
21Vibrio cholerae infection_Homo sapiens_hsa051101.49991817
22* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47748771
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.47298429
24Morphine addiction_Homo sapiens_hsa050321.46128600
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.42586201
26Dopaminergic synapse_Homo sapiens_hsa047281.42342536
27Serotonergic synapse_Homo sapiens_hsa047261.41042859
28Oocyte meiosis_Homo sapiens_hsa041141.39476192
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38660463
30Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.36060991
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33729756
32GABAergic synapse_Homo sapiens_hsa047271.33022076
33Long-term potentiation_Homo sapiens_hsa047201.32372591
34Phagosome_Homo sapiens_hsa041451.32038977
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.28063812
36Phototransduction_Homo sapiens_hsa047441.27580835
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26443510
38Neurotrophin signaling pathway_Homo sapiens_hsa047221.22006886
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21657362
40Type II diabetes mellitus_Homo sapiens_hsa049301.18365098
41Basal transcription factors_Homo sapiens_hsa030221.18079593
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16750853
43ErbB signaling pathway_Homo sapiens_hsa040121.12312483
44Fatty acid metabolism_Homo sapiens_hsa012121.11128152
45Taste transduction_Homo sapiens_hsa047421.07031621
46Amphetamine addiction_Homo sapiens_hsa050311.07002042
47AMPK signaling pathway_Homo sapiens_hsa041521.06452857
48Rheumatoid arthritis_Homo sapiens_hsa053231.04908025
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04605424
50mRNA surveillance pathway_Homo sapiens_hsa030151.03529214
51Long-term depression_Homo sapiens_hsa047301.03439686
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01705184
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01046825
54Insulin secretion_Homo sapiens_hsa049111.00069183
55Melanoma_Homo sapiens_hsa052180.99428433
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99248753
57Wnt signaling pathway_Homo sapiens_hsa043100.98835437
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98568541
59Endometrial cancer_Homo sapiens_hsa052130.98166169
60TGF-beta signaling pathway_Homo sapiens_hsa043500.97361676
61Salmonella infection_Homo sapiens_hsa051320.97046301
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96341096
63Colorectal cancer_Homo sapiens_hsa052100.95252640
64Gastric acid secretion_Homo sapiens_hsa049710.94214520
65Salivary secretion_Homo sapiens_hsa049700.93683016
66Pyruvate metabolism_Homo sapiens_hsa006200.93286288
67Renin secretion_Homo sapiens_hsa049240.91597246
68Oxytocin signaling pathway_Homo sapiens_hsa049210.90199599
69Gap junction_Homo sapiens_hsa045400.89386414
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88280417
71Lysine degradation_Homo sapiens_hsa003100.87067813
72Ras signaling pathway_Homo sapiens_hsa040140.86382700
73Glioma_Homo sapiens_hsa052140.85511757
74Estrogen signaling pathway_Homo sapiens_hsa049150.85408302
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85231158
76Fatty acid elongation_Homo sapiens_hsa000620.85128847
77Melanogenesis_Homo sapiens_hsa049160.84800344
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83677304
79Cocaine addiction_Homo sapiens_hsa050300.83012296
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82826107
81Thyroid cancer_Homo sapiens_hsa052160.82171254
82Hedgehog signaling pathway_Homo sapiens_hsa043400.81193821
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80535862
84cAMP signaling pathway_Homo sapiens_hsa040240.79213914
85Endocytosis_Homo sapiens_hsa041440.78263697
86Basal cell carcinoma_Homo sapiens_hsa052170.77520923
87Renal cell carcinoma_Homo sapiens_hsa052110.76973851
88Regulation of autophagy_Homo sapiens_hsa041400.76859292
89Circadian rhythm_Homo sapiens_hsa047100.76451352
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75337306
91MAPK signaling pathway_Homo sapiens_hsa040100.74584745
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74475389
93Insulin signaling pathway_Homo sapiens_hsa049100.74437658
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.74315895
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73574335
96beta-Alanine metabolism_Homo sapiens_hsa004100.73222052
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72920888
98Ovarian steroidogenesis_Homo sapiens_hsa049130.72091839
99Prostate cancer_Homo sapiens_hsa052150.72000309
100Inositol phosphate metabolism_Homo sapiens_hsa005620.71744828
101Calcium signaling pathway_Homo sapiens_hsa040200.71711255
102GnRH signaling pathway_Homo sapiens_hsa049120.69026656
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.67891693
104Vitamin B6 metabolism_Homo sapiens_hsa007500.67518157
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67444690
106MicroRNAs in cancer_Homo sapiens_hsa052060.66666038
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66516742
108Tuberculosis_Homo sapiens_hsa051520.66327688
109Shigellosis_Homo sapiens_hsa051310.66163872
110mTOR signaling pathway_Homo sapiens_hsa041500.65848814
111Chemokine signaling pathway_Homo sapiens_hsa040620.64759091
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63635519
113Focal adhesion_Homo sapiens_hsa045100.63238400
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.63094143
115Dilated cardiomyopathy_Homo sapiens_hsa054140.61791335
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61572485
117Prolactin signaling pathway_Homo sapiens_hsa049170.61108946
118Rap1 signaling pathway_Homo sapiens_hsa040150.60473739
119Cell cycle_Homo sapiens_hsa041100.59565566
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58681157
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58483562
122Sphingolipid metabolism_Homo sapiens_hsa006000.58388610
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57657036
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57114138
125Dorso-ventral axis formation_Homo sapiens_hsa043200.54386356
126RNA transport_Homo sapiens_hsa030130.54267231
127RNA degradation_Homo sapiens_hsa030180.53705737
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53285300
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52157958
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52081879
131Fatty acid biosynthesis_Homo sapiens_hsa000610.50289340
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50115086
133Glucagon signaling pathway_Homo sapiens_hsa049220.49708806
134Hippo signaling pathway_Homo sapiens_hsa043900.49611571
135Choline metabolism in cancer_Homo sapiens_hsa052310.49402199
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49173353
137Adherens junction_Homo sapiens_hsa045200.47422226
138Alcoholism_Homo sapiens_hsa050340.47154833
139Tight junction_Homo sapiens_hsa045300.46256285
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45893326
141Pathways in cancer_Homo sapiens_hsa052000.44975552

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