DCTN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.12910007
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.66945620
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.45803592
4locomotory exploration behavior (GO:0035641)5.41895698
5layer formation in cerebral cortex (GO:0021819)4.77105142
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.70182494
7sodium ion export (GO:0071436)4.65730580
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.64252509
9synaptic vesicle exocytosis (GO:0016079)4.59919976
10regulation of synaptic vesicle exocytosis (GO:2000300)4.55091023
11glutamate secretion (GO:0014047)4.53822705
12vocalization behavior (GO:0071625)4.48301754
13regulation of synapse structural plasticity (GO:0051823)4.42051444
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.31073241
15cellular potassium ion homeostasis (GO:0030007)4.22414369
16cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.15652779
17regulation of glutamate receptor signaling pathway (GO:1900449)4.06837192
18regulation of synaptic vesicle transport (GO:1902803)4.00941572
19cell communication by electrical coupling (GO:0010644)4.00173272
20exploration behavior (GO:0035640)3.98682389
21neurotransmitter secretion (GO:0007269)3.95174196
22cerebellar granule cell differentiation (GO:0021707)3.93824968
23activation of protein kinase A activity (GO:0034199)3.91372069
24protein localization to synapse (GO:0035418)3.87396174
25regulation of neuronal synaptic plasticity (GO:0048168)3.81197142
26proline transport (GO:0015824)3.72903853
27dendritic spine morphogenesis (GO:0060997)3.64161118
28amino acid import (GO:0043090)3.62918045
29positive regulation of synapse maturation (GO:0090129)3.62792748
30positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.62295525
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.58853479
32neuromuscular process controlling balance (GO:0050885)3.56604463
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.51296980
34neuronal action potential propagation (GO:0019227)3.49287762
35ionotropic glutamate receptor signaling pathway (GO:0035235)3.47716990
36cytoskeletal anchoring at plasma membrane (GO:0007016)3.41654109
37cell migration in hindbrain (GO:0021535)3.38947460
38glycine transport (GO:0015816)3.38649139
39gamma-aminobutyric acid transport (GO:0015812)3.34500598
40dendrite morphogenesis (GO:0048813)3.33026971
41regulation of ARF protein signal transduction (GO:0032012)3.30320219
42regulation of synapse maturation (GO:0090128)3.30226463
43cell communication involved in cardiac conduction (GO:0086065)3.25580254
44L-amino acid import (GO:0043092)3.23289627
45cerebellar Purkinje cell differentiation (GO:0021702)3.20614959
46postsynaptic membrane organization (GO:0001941)3.19959453
47potassium ion import (GO:0010107)3.19532692
48regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.19489927
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.19018504
50membrane depolarization during action potential (GO:0086010)3.16660692
51neuron cell-cell adhesion (GO:0007158)3.15647058
52negative regulation of microtubule polymerization (GO:0031115)3.13981542
53cerebellar Purkinje cell layer development (GO:0021680)3.13904265
54vesicle transport along microtubule (GO:0047496)3.12496799
55potassium ion homeostasis (GO:0055075)3.11285393
56synaptic transmission, glutamatergic (GO:0035249)3.11068025
57negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.10047569
58establishment of mitochondrion localization (GO:0051654)3.09780816
59long-term memory (GO:0007616)3.09285797
60positive regulation of dendritic spine development (GO:0060999)3.09164676
61establishment of nucleus localization (GO:0040023)3.08902652
62synaptic vesicle endocytosis (GO:0048488)3.07663843
63cellular sodium ion homeostasis (GO:0006883)3.06470191
64neurotransmitter transport (GO:0006836)3.06241489
65axon cargo transport (GO:0008088)3.05533479
66neuromuscular process controlling posture (GO:0050884)3.04862196
67positive regulation of synaptic transmission, GABAergic (GO:0032230)3.04280482
68organelle transport along microtubule (GO:0072384)3.04052333
69G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.02591196
70neurotransmitter-gated ion channel clustering (GO:0072578)3.01458491
71positive regulation of membrane potential (GO:0045838)2.99720053
72regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.98256030
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.97739510
74regulation of clathrin-mediated endocytosis (GO:2000369)2.97282822
75glutamate receptor signaling pathway (GO:0007215)2.97116536
76neuron recognition (GO:0008038)2.95410912
77regulation of dendritic spine morphogenesis (GO:0061001)2.94407054
78mating behavior (GO:0007617)2.94300647
79positive regulation of dendritic spine morphogenesis (GO:0061003)2.93257004
80positive regulation of potassium ion transmembrane transport (GO:1901381)2.93239297
81regulation of excitatory postsynaptic membrane potential (GO:0060079)2.91720478
82regulation of synaptic plasticity (GO:0048167)2.90080672
83plasma membrane repair (GO:0001778)2.88812872
84negative regulation of dendrite morphogenesis (GO:0050774)2.88755929
85membrane repolarization (GO:0086009)2.88646317
86prepulse inhibition (GO:0060134)2.86602882
87regulation of neurotransmitter secretion (GO:0046928)2.86292209
88protein retention in ER lumen (GO:0006621)2.85853651
89protein localization to endosome (GO:0036010)2.85070391
90positive regulation of neurotransmitter transport (GO:0051590)2.84359210
91axonal fasciculation (GO:0007413)2.84113979
92neuron-neuron synaptic transmission (GO:0007270)2.83438348
93auditory behavior (GO:0031223)2.82901962
94neuronal ion channel clustering (GO:0045161)2.81703227
95regulation of postsynaptic membrane potential (GO:0060078)2.81139209
96response to pheromone (GO:0019236)2.80619411
97positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.80119055
98response to auditory stimulus (GO:0010996)2.80118169
99regulation of neurotransmitter levels (GO:0001505)2.79594688
100innervation (GO:0060384)2.78640884
101mitochondrion transport along microtubule (GO:0047497)2.77939610
102establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.77939610
103axon extension (GO:0048675)2.76919113
104protein targeting to plasma membrane (GO:0072661)2.76873929
105positive regulation of neurotransmitter secretion (GO:0001956)2.76787586
106regulation of vesicle fusion (GO:0031338)2.76743621
107negative regulation of cytosolic calcium ion concentration (GO:0051481)2.76572963
108dopamine receptor signaling pathway (GO:0007212)2.75166185
109neuromuscular process (GO:0050905)2.70249524
110regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.69789747
111clathrin coat assembly (GO:0048268)2.69663886
112regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.68792597
113neuron projection extension (GO:1990138)2.68674253
114dendritic spine organization (GO:0097061)2.67882228
115regulation of membrane repolarization (GO:0060306)2.66341459
116membrane hyperpolarization (GO:0060081)2.66063672
117negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66021858
118membrane depolarization (GO:0051899)2.66004433
119maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.64645518
120adherens junction assembly (GO:0034333)2.63880351
121cellular response to monoamine stimulus (GO:0071868)2.61417772
122cellular response to catecholamine stimulus (GO:0071870)2.61417772
123regulation of neurotransmitter transport (GO:0051588)2.61188106
124regulation of voltage-gated calcium channel activity (GO:1901385)2.60086058
125positive regulation of dendrite development (GO:1900006)2.58841486
126regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.57491278
127retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.51691474
128central nervous system myelination (GO:0022010)2.50407191
129axon ensheathment in central nervous system (GO:0032291)2.50407191
130semaphorin-plexin signaling pathway (GO:0071526)2.47334643
131regulation of dendrite morphogenesis (GO:0048814)2.41542692
132adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.41324617
133regulation of NFAT protein import into nucleus (GO:0051532)2.40155850
134vesicle docking involved in exocytosis (GO:0006904)2.39545175

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.88156766
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.97795120
3DROSHA_22980978_ChIP-Seq_HELA_Human2.78812275
4* RARB_27405468_Chip-Seq_BRAIN_Mouse2.74641240
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65361107
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59251879
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58016923
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58016923
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54559792
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41467571
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38006828
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37892922
13REST_21632747_ChIP-Seq_MESCs_Mouse2.35531703
14* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.29357470
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.21085675
16SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20742833
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19710079
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13367064
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.10682308
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10443101
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.09887706
22KDM2B_26808549_Chip-Seq_K562_Human2.07630310
23ZFP281_18757296_ChIP-ChIP_E14_Mouse2.07071873
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.06937817
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06426997
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04344345
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96865939
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.92580599
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92078086
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82498216
31DNAJC2_21179169_ChIP-ChIP_NT2_Human1.80023457
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78016540
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.77301467
34EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.77053622
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.74761280
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74288358
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.74284568
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.74230349
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.62762233
40GBX2_23144817_ChIP-Seq_PC3_Human1.62550544
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59703073
42CLOCK_20551151_ChIP-Seq_293T_Human1.57816077
43KDM2B_26808549_Chip-Seq_DND41_Human1.56865675
44* LXR_22292898_ChIP-Seq_THP-1_Human1.56260355
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.55485930
46ZFP281_27345836_Chip-Seq_ESCs_Mouse1.52124780
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45725057
48GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43374111
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.42853073
50WT1_25993318_ChIP-Seq_PODOCYTE_Human1.40367866
51RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38160399
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35582275
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33525885
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.32485878
55AR_21572438_ChIP-Seq_LNCaP_Human1.32361434
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.31638768
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31211387
58* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30720950
59CTCF_27219007_Chip-Seq_Bcells_Human1.30391943
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28048841
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25629826
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24949617
63TCF7_22412390_ChIP-Seq_EML_Mouse1.22081704
64RING1B_27294783_Chip-Seq_NPCs_Mouse1.21333715
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20599449
66ZNF263_19887448_ChIP-Seq_K562_Human1.20026097
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19488562
68TET1_21490601_ChIP-Seq_MESCs_Mouse1.19354427
69AR_19668381_ChIP-Seq_PC3_Human1.18847124
70* TP53_23651856_ChIP-Seq_MEFs_Mouse1.14503863
71SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13106514
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.13032693
73SMC4_20622854_ChIP-Seq_HELA_Human1.12147294
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.11510681
75ZNF274_21170338_ChIP-Seq_K562_Hela1.10111656
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10042129
77* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09814399
78SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09622454
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09546378
80TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.08959962
81CREB1_26743006_Chip-Seq_LNCaP_Human1.08312563
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06750440
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06148641
84TP53_22127205_ChIP-Seq_IMR90_Human1.05833480
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04618429
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03034356
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02809690
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.02704850
89POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02475455
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02374299
91SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01317280
92CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00627527
93NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00390355
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99086604
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97124506
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97059715
97KLF4_19829295_ChIP-Seq_ESCs_Human0.96699221
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96574319
99P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96050641
100ESR1_20079471_ChIP-ChIP_T-47D_Human0.95857621
101AHR_22903824_ChIP-Seq_MCF-7_Human0.95547385
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94784647
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93807887
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93684630
105OCT4_19829295_ChIP-Seq_ESCs_Human0.93387678
106EP300_21415370_ChIP-Seq_HL-1_Mouse0.92530455
107PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92451591
108RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91660861
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.91541978
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91540197
111TBX20_22328084_ChIP-Seq_HEART_Mouse0.91157426
112TBX20_22080862_ChIP-Seq_HEART_Mouse0.91157426
113* SA1_27219007_Chip-Seq_ERYTHROID_Human0.90989406
114* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90903158
115ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90309613
116TP53_20018659_ChIP-ChIP_R1E_Mouse0.90072886
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87798058
118SMAD4_21799915_ChIP-Seq_A2780_Human0.87268742
119MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87232989
120SMAD3_21741376_ChIP-Seq_ESCs_Human0.87072331
121* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86972329
122SMAD3_21741376_ChIP-Seq_HESCs_Human0.85764152
123CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85454431
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85318190
125P68_20966046_ChIP-Seq_HELA_Human0.84856013
126ARNT_22903824_ChIP-Seq_MCF-7_Human0.84671238
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84465824
128RACK7_27058665_Chip-Seq_MCF-7_Human0.83899087
129P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83834792

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.46122656
2MP0003635_abnormal_synaptic_transmissio3.77300165
3MP0004270_analgesia3.73891237
4MP0003880_abnormal_central_pattern3.21227995
5MP0002063_abnormal_learning/memory/cond2.89363975
6MP0009745_abnormal_behavioral_response2.75212374
7MP0004858_abnormal_nervous_system2.73931319
8MP0001968_abnormal_touch/_nociception2.72383875
9MP0002064_seizures2.67779947
10MP0005423_abnormal_somatic_nervous2.65243240
11MP0009046_muscle_twitch2.62070929
12MP0002734_abnormal_mechanical_nocicepti2.53361595
13MP0008438_abnormal_cutaneous_collagen2.46175627
14MP0002822_catalepsy2.30782035
15MP0000751_myopathy2.25112995
16MP0009780_abnormal_chondrocyte_physiolo2.23699413
17MP0002909_abnormal_adrenal_gland2.23684302
18MP0002272_abnormal_nervous_system2.18391425
19MP0002735_abnormal_chemical_nociception2.15919890
20MP0002572_abnormal_emotion/affect_behav2.15785411
21MP0003329_amyloid_beta_deposits2.12463182
22MP0002733_abnormal_thermal_nociception2.09886844
23MP0001486_abnormal_startle_reflex1.98989684
24MP0002736_abnormal_nociception_after1.96818088
25MP0004811_abnormal_neuron_physiology1.95840332
26MP0008569_lethality_at_weaning1.93771834
27MP0001970_abnormal_pain_threshold1.92815079
28MP0002184_abnormal_innervation1.81623379
29MP0008961_abnormal_basal_metabolism1.66910661
30MP0001440_abnormal_grooming_behavior1.66860196
31MP0002067_abnormal_sensory_capabilities1.65670906
32MP0003283_abnormal_digestive_organ1.65382242
33MP0004885_abnormal_endolymph1.61745471
34MP0003123_paternal_imprinting1.61396196
35* MP0000955_abnormal_spinal_cord1.61364325
36MP0000778_abnormal_nervous_system1.59817026
37MP0005409_darkened_coat_color1.56931406
38MP0001501_abnormal_sleep_pattern1.53274718
39MP0004145_abnormal_muscle_electrophysio1.48486523
40MP0002557_abnormal_social/conspecific_i1.46154383
41MP0003566_abnormal_cell_adhesion1.45591975
42MP0001958_emphysema1.45389147
43MP0005623_abnormal_meninges_morphology1.44494718
44* MP0002882_abnormal_neuron_morphology1.43769043
45MP0003879_abnormal_hair_cell1.39799336
46MP0005386_behavior/neurological_phenoty1.37152181
47MP0004924_abnormal_behavior1.37152181
48MP0001849_ear_inflammation1.35737959
49MP0005257_abnormal_intraocular_pressure1.34146133
50MP0003633_abnormal_nervous_system1.32772384
51MP0000569_abnormal_digit_pigmentation1.32251128
52MP0004233_abnormal_muscle_weight1.31290703
53* MP0002066_abnormal_motor_capabilities/c1.29420480
54MP0006276_abnormal_autonomic_nervous1.28104795
55MP0000013_abnormal_adipose_tissue1.26324105
56MP0004272_abnormal_basement_membrane1.26222238
57MP0001984_abnormal_olfaction1.23049173
58MP0003091_abnormal_cell_migration1.17540113
59MP0002837_dystrophic_cardiac_calcinosis1.16979005
60MP0001502_abnormal_circadian_rhythm1.16953844
61MP0003122_maternal_imprinting1.15213443
62MP0000747_muscle_weakness1.13925245
63MP0003279_aneurysm1.12192854
64MP0004130_abnormal_muscle_cell1.08561164
65MP0003787_abnormal_imprinting1.07927015
66MP0002152_abnormal_brain_morphology1.07413094
67MP0003634_abnormal_glial_cell1.05542056
68MP0004085_abnormal_heartbeat1.04616528
69MP0003631_nervous_system_phenotype1.04573410
70MP0004215_abnormal_myocardial_fiber1.03686947
71MP0005551_abnormal_eye_electrophysiolog1.02911066
72MP0005645_abnormal_hypothalamus_physiol1.02105828
73MP0010234_abnormal_vibrissa_follicle1.01529739
74MP0004084_abnormal_cardiac_muscle1.00655000
75MP0000579_abnormal_nail_morphology0.99436626
76MP0003137_abnormal_impulse_conducting0.99146115
77* MP0002229_neurodegeneration0.98904226
78MP0002877_abnormal_melanocyte_morpholog0.98340162
79MP0003075_altered_response_to0.96937346
80MP0005167_abnormal_blood-brain_barrier0.95688449
81MP0004510_myositis0.94680594
82MP0003385_abnormal_body_wall0.93250511
83MP0000537_abnormal_urethra_morphology0.92134061
84MP0004036_abnormal_muscle_relaxation0.92108012
85MP0001348_abnormal_lacrimal_gland0.91510989
86* MP0003861_abnormal_nervous_system0.90176787
87MP0000604_amyloidosis0.89727631
88MP0003705_abnormal_hypodermis_morpholog0.89205159
89MP0004087_abnormal_muscle_fiber0.88707206
90MP0008874_decreased_physiological_sensi0.88140503
91MP0002089_abnormal_postnatal_growth/wei0.88034950
92MP0003172_abnormal_lysosome_physiology0.87075651
93MP0001299_abnormal_eye_distance/0.86971241
94MP0002090_abnormal_vision0.86638958
95MP0001346_abnormal_lacrimal_gland0.85468194
96MP0000749_muscle_degeneration0.85463538
97MP0005394_taste/olfaction_phenotype0.84722119
98MP0005499_abnormal_olfactory_system0.84722119
99MP0002249_abnormal_larynx_morphology0.84054034
100MP0000003_abnormal_adipose_tissue0.82585974
101MP0002069_abnormal_eating/drinking_beha0.82316491
102MP0005275_abnormal_skin_tensile0.80575989
103MP0002234_abnormal_pharynx_morphology0.80152178
104MP0009672_abnormal_birth_weight0.79082641
105MP0010030_abnormal_orbit_morphology0.77634550
106MP0000733_abnormal_muscle_development0.76920270
107MP0003045_fibrosis0.76409872
108MP0005187_abnormal_penis_morphology0.75973268
109MP0003115_abnormal_respiratory_system0.74973282
110MP0005076_abnormal_cell_differentiation0.74736344
111MP0008260_abnormal_autophagy0.74734717
112MP0001529_abnormal_vocalization0.74374098
113MP0002896_abnormal_bone_mineralization0.74026360
114MP0000759_abnormal_skeletal_muscle0.73159451
115MP0004484_altered_response_of0.72890783
116MP0000462_abnormal_digestive_system0.72801144
117MP0005620_abnormal_muscle_contractility0.72713593
118MP0003942_abnormal_urinary_system0.72385987
119MP0001943_abnormal_respiration0.72302270
120MP0010368_abnormal_lymphatic_system0.72082912
121MP0005503_abnormal_tendon_morphology0.71818230
122MP0004142_abnormal_muscle_tone0.71482970
123* MP0002752_abnormal_somatic_nervous0.71318377
124MP0000534_abnormal_ureter_morphology0.70729268
125MP0000920_abnormal_myelination0.70723321
126MP0003690_abnormal_glial_cell0.70457500
127MP0003632_abnormal_nervous_system0.70110282
128MP0002081_perinatal_lethality0.69813384
129MP0003646_muscle_fatigue0.69671384
130MP0002653_abnormal_ependyma_morphology0.69576027
131MP0001177_atelectasis0.69442417
132MP0002269_muscular_atrophy0.69246655
133MP0006072_abnormal_retinal_apoptosis0.67716156

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.89612948
2Visual hallucinations (HP:0002367)4.57391919
3Focal motor seizures (HP:0011153)4.32265187
4Focal seizures (HP:0007359)4.27780214
5Action tremor (HP:0002345)3.92579318
6Ankle clonus (HP:0011448)3.79616799
7Protrusio acetabuli (HP:0003179)3.54015175
8Ventricular fibrillation (HP:0001663)3.20668377
9Hyperacusis (HP:0010780)3.20602659
10Progressive cerebellar ataxia (HP:0002073)3.17030304
11Premature rupture of membranes (HP:0001788)3.13260815
12Epileptic encephalopathy (HP:0200134)2.95962824
13* Supranuclear gaze palsy (HP:0000605)2.94842812
14Mutism (HP:0002300)2.87557961
15Hemiplegia (HP:0002301)2.84127948
16Papilledema (HP:0001085)2.83682138
17Urinary bladder sphincter dysfunction (HP:0002839)2.82770864
18Atonic seizures (HP:0010819)2.80917042
19Shallow orbits (HP:0000586)2.78149062
20* Depression (HP:0000716)2.77324949
21Urinary urgency (HP:0000012)2.76086064
22Pointed chin (HP:0000307)2.75122736
23Poor eye contact (HP:0000817)2.74712209
24Absence seizures (HP:0002121)2.74149976
25Generalized tonic-clonic seizures (HP:0002069)2.74053560
26Bundle branch block (HP:0011710)2.71053645
27Postural instability (HP:0002172)2.68696366
28Impaired social interactions (HP:0000735)2.67460733
29Abnormal social behavior (HP:0012433)2.67460733
30Febrile seizures (HP:0002373)2.65539485
31Impaired vibration sensation in the lower limbs (HP:0002166)2.60152767
32Dysmetric saccades (HP:0000641)2.59082152
33Dysdiadochokinesis (HP:0002075)2.56863812
34Torticollis (HP:0000473)2.54888774
35Truncal ataxia (HP:0002078)2.54089229
36Termporal pattern (HP:0011008)2.51411920
37Insidious onset (HP:0003587)2.51411920
38Genetic anticipation (HP:0003743)2.47247848
39Dialeptic seizures (HP:0011146)2.41272195
40Distal lower limb amyotrophy (HP:0008944)2.41254478
41Annular pancreas (HP:0001734)2.39707822
42Bladder diverticulum (HP:0000015)2.38086702
43Anxiety (HP:0000739)2.37688158
44Increased connective tissue (HP:0009025)2.36023868
45Dysmetria (HP:0001310)2.35344951
46Cerebral inclusion bodies (HP:0100314)2.34949444
47Elfin facies (HP:0004428)2.34928075
48Abnormal eating behavior (HP:0100738)2.34802586
49Hypercortisolism (HP:0001578)2.34476112
50Difficulty climbing stairs (HP:0003551)2.33212739
51Atrophic scars (HP:0001075)2.32315607
52Spastic gait (HP:0002064)2.31458258
53Turricephaly (HP:0000262)2.31359525
54Sudden death (HP:0001699)2.28205433
55Peripheral hypomyelination (HP:0007182)2.24845488
56Focal dystonia (HP:0004373)2.24664505
57Amblyopia (HP:0000646)2.23487499
58Difficulty running (HP:0009046)2.22047328
59* Insomnia (HP:0100785)2.21957262
60Prolonged QT interval (HP:0001657)2.21696869
61Lower limb amyotrophy (HP:0007210)2.21048490
62Neoplasm of the heart (HP:0100544)2.20942469
63Megalencephaly (HP:0001355)2.20344486
64Vascular tortuosity (HP:0004948)2.19113261
65Cerebral aneurysm (HP:0004944)2.18384782
66Tetraplegia (HP:0002445)2.17445937
67Broad metatarsal (HP:0001783)2.17109381
68Fragile skin (HP:0001030)2.15278029
69Hemiparesis (HP:0001269)2.14950533
70Impaired smooth pursuit (HP:0007772)2.14802603
71Pheochromocytoma (HP:0002666)2.14796824
72Neurofibrillary tangles (HP:0002185)2.13469258
73Gaze-evoked nystagmus (HP:0000640)2.11908906
74Central scotoma (HP:0000603)2.11678379
75Arterial tortuosity (HP:0005116)2.11637789
76Abnormal EKG (HP:0003115)2.11184788
77Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.11009930
78Ulnar bowing (HP:0003031)2.10226463
79Exercise-induced myalgia (HP:0003738)2.09169254
80Overriding aorta (HP:0002623)2.08685059
81Intention tremor (HP:0002080)2.07462684
82Broad-based gait (HP:0002136)2.06139332
83Craniofacial dystonia (HP:0012179)2.04712015
84Myotonia (HP:0002486)2.04573080
85Spinal rigidity (HP:0003306)2.03720339
86Stereotypic behavior (HP:0000733)2.01451930
87Bronchomalacia (HP:0002780)2.00838237
88Mildly elevated creatine phosphokinase (HP:0008180)2.00772626
89Amyotrophic lateral sclerosis (HP:0007354)2.00424483
90Abnormality of the corticospinal tract (HP:0002492)1.99786186
91Akinesia (HP:0002304)1.98845292
92Abnormality of dentin (HP:0010299)1.98431312
93* Distal upper limb amyotrophy (HP:0007149)1.97688762
94* Upper limb amyotrophy (HP:0009129)1.97688762
95Wormian bones (HP:0002645)1.97203574
96Limb dystonia (HP:0002451)1.96587727
97Increased variability in muscle fiber diameter (HP:0003557)1.96296558
98Resting tremor (HP:0002322)1.95932154
99Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.94730669
100Achilles tendon contracture (HP:0001771)1.94533000
101Clonus (HP:0002169)1.94080540
102Macroorchidism (HP:0000053)1.93922114
103Mitral regurgitation (HP:0001653)1.93323571
104* Rapidly progressive (HP:0003678)1.92637846
105Agitation (HP:0000713)1.91963003
106Aplasia involving bones of the upper limbs (HP:0009823)1.91120874
107Aplasia of the phalanges of the hand (HP:0009802)1.91120874
108Aplasia involving bones of the extremities (HP:0009825)1.91120874
109Neuronal loss in central nervous system (HP:0002529)1.90992256
110Renovascular hypertension (HP:0100817)1.89866175
111Genu recurvatum (HP:0002816)1.89665076
112Hammertoe (HP:0001765)1.88812172
113Abnormality of ocular smooth pursuit (HP:0000617)1.87337020
114Failure to thrive in infancy (HP:0001531)1.87261999
115Hyporeflexia of lower limbs (HP:0002600)1.86043431
116Ankle contracture (HP:0006466)1.84564598
117Bowel diverticulosis (HP:0005222)1.84126465
118Ankyloglossia (HP:0010296)1.84106595
119Cerebral hypomyelination (HP:0006808)1.82855619
120Diplopia (HP:0000651)1.82655764
121Abnormality of binocular vision (HP:0011514)1.82655764
122Abnormality of skeletal muscle fiber size (HP:0012084)1.81712708
123Centrally nucleated skeletal muscle fibers (HP:0003687)1.81543562
124Syncope (HP:0001279)1.81429312
125Renal duplication (HP:0000075)1.80620997
126Abnormality of pain sensation (HP:0010832)1.80068298
127Impaired pain sensation (HP:0007328)1.80068298
128Mild short stature (HP:0003502)1.79129073
129Obstructive sleep apnea (HP:0002870)1.77853219
130Distal sensory impairment (HP:0002936)1.77092739
131Vertebral compression fractures (HP:0002953)1.76232141
132Vertebral arch anomaly (HP:0008438)1.75542102
133* Lower limb muscle weakness (HP:0007340)1.74919582
134Long palpebral fissure (HP:0000637)1.74866004
135Precocious puberty (HP:0000826)1.74774338
136Flat cornea (HP:0007720)1.74732091
137Lower limb asymmetry (HP:0100559)1.74670044
138Arnold-Chiari malformation (HP:0002308)1.74579311
139Sleep apnea (HP:0010535)1.72765526
140Type 1 muscle fiber predominance (HP:0003803)1.72317122
141Scanning speech (HP:0002168)1.71891504
142Neonatal short-limb short stature (HP:0008921)1.71660219
143Neoplasm of the peripheral nervous system (HP:0100007)1.71416798
144Back pain (HP:0003418)1.71261253
145Anosmia (HP:0000458)1.70736461
146Foot dorsiflexor weakness (HP:0009027)1.70568390
147Decreased motor nerve conduction velocity (HP:0003431)1.68764845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.95114352
2NTRK33.27610598
3MARK13.14788540
4MINK12.62956884
5PAK62.60016059
6KSR22.54748457
7PRKD32.48947960
8EPHA42.39700456
9MAP3K42.39211811
10DAPK22.30975968
11NTRK12.20950748
12TRIB32.20060789
13CAMKK12.16495650
14RIPK11.92432488
15PHKG11.80460294
16PHKG21.80460294
17LMTK21.77353495
18NTRK21.75931630
19SIK21.73631366
20CDK121.65994588
21PKN21.59377442
22MAP2K41.56582804
23STK381.55307076
24MAP3K21.54033419
25TESK11.53820561
26LATS21.51953979
27TYRO31.50301608
28TAOK11.50292833
29CDK51.42288276
30RET1.37630914
31SMG11.32353490
32KSR11.32060334
33MAP2K71.30574220
34ALK1.20285398
35UHMK11.18675299
36SCYL21.18235969
37EEF2K1.11020608
38PRKCH1.10483921
39ICK1.08102055
40NEK11.07058241
41SIK11.06967471
42DAPK11.03276684
43PDGFRA1.00936169
44MARK20.99345042
45PAK30.98398563
46GRK50.97637913
47CASK0.97173448
48CAMK2B0.96354143
49FGFR40.96277220
50STK110.96262884
51CAMK1G0.91768326
52RIPK40.91461600
53CAMKK20.90447116
54CDK150.87958191
55FES0.87508222
56MAPK130.86274095
57CDK180.85329853
58CDK140.85315233
59PAK20.82098319
60DMPK0.79722521
61PRKCG0.79038047
62MAP3K70.79018362
63CDC42BPA0.77950747
64CAMK10.77913904
65MAP3K10.77740073
66CDK11A0.77369113
67ARAF0.77169523
68TTN0.77045735
69MTOR0.76638093
70RPS6KA20.74761102
71EPHB10.74660063
72MOS0.73833681
73SGK4940.73521246
74SGK2230.73521246
75MAP3K120.72266725
76CAMK2G0.72225690
77SGK30.71284016
78MAP3K100.70587793
79BMX0.70258410
80MAP3K130.69595621
81BRAF0.68986716
82WNK10.67602236
83FER0.67417770
84DDR20.66806102
85LIMK10.65710903
86PRPF4B0.64302615
87PDPK10.64066909
88PINK10.63653720
89PDK10.61965096
90PTK2B0.60420621
91BRSK10.59163637
92TNK20.56073394
93PNCK0.56071988
94EPHB20.55978119
95MAP2K10.53873151
96PTK60.53043261
97MAPK120.52046766
98PRKCZ0.51903182
99DAPK30.51894564
100PRKD20.51602728
101PLK20.51370212
102CAMK2A0.51277001
103FYN0.50588441
104PTK20.49922022
105DYRK1B0.49715870
106RPS6KA30.48813239
107SGK10.47665089
108CDK190.47640573
109TAOK20.47281517
110PRKD10.47062303
111ROCK10.46195205
112CAMK40.45897468
113PDGFRB0.45152986
114MAP3K60.44817326
115DYRK1A0.44313123
116CSNK1G20.44217774
117MAPKAPK30.44190606
118CAMK1D0.44108120
119RAF10.43652841
120ROCK20.42196785
121MAPK100.40793700
122SGK20.39811206
123NEK60.39748994
124BRD40.39082281
125FGFR20.38956535
126CAMK2D0.38916539
127PAK40.38303321
128MAP3K110.38210281

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.91781223
2Olfactory transduction_Homo sapiens_hsa047402.55308060
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.54463827
4Nicotine addiction_Homo sapiens_hsa050332.26534841
5Circadian entrainment_Homo sapiens_hsa047132.24332771
6GABAergic synapse_Homo sapiens_hsa047272.18591137
7Long-term potentiation_Homo sapiens_hsa047202.09730447
8Glutamatergic synapse_Homo sapiens_hsa047242.00017025
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.95102026
10Morphine addiction_Homo sapiens_hsa050321.93933877
11Dopaminergic synapse_Homo sapiens_hsa047281.85912690
12Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.84206238
13Insulin secretion_Homo sapiens_hsa049111.82740383
14Gastric acid secretion_Homo sapiens_hsa049711.82125912
15Salivary secretion_Homo sapiens_hsa049701.79977884
16Cholinergic synapse_Homo sapiens_hsa047251.78585634
17Amphetamine addiction_Homo sapiens_hsa050311.77861741
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72850886
19* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63378560
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.56041913
21Oxytocin signaling pathway_Homo sapiens_hsa049211.55687014
22GnRH signaling pathway_Homo sapiens_hsa049121.46431554
23Type II diabetes mellitus_Homo sapiens_hsa049301.45855485
24Renin secretion_Homo sapiens_hsa049241.43309684
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37487850
26Gap junction_Homo sapiens_hsa045401.36741533
27Cocaine addiction_Homo sapiens_hsa050301.36364822
28Glioma_Homo sapiens_hsa052141.35123279
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30579889
30Estrogen signaling pathway_Homo sapiens_hsa049151.29259073
31Long-term depression_Homo sapiens_hsa047301.24425655
32Taste transduction_Homo sapiens_hsa047421.23045641
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22543397
34Calcium signaling pathway_Homo sapiens_hsa040201.20632075
35Dilated cardiomyopathy_Homo sapiens_hsa054141.18644423
36cAMP signaling pathway_Homo sapiens_hsa040241.14911005
37Nitrogen metabolism_Homo sapiens_hsa009101.14565874
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13157765
39Axon guidance_Homo sapiens_hsa043601.10516554
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08993023
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.05709165
42Serotonergic synapse_Homo sapiens_hsa047261.05707127
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04430162
44ErbB signaling pathway_Homo sapiens_hsa040121.03804058
45Dorso-ventral axis formation_Homo sapiens_hsa043201.01018878
46VEGF signaling pathway_Homo sapiens_hsa043701.00237542
47Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99643005
48Melanogenesis_Homo sapiens_hsa049160.98674744
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.98581733
50mTOR signaling pathway_Homo sapiens_hsa041500.98072063
51ECM-receptor interaction_Homo sapiens_hsa045120.97462069
52Phototransduction_Homo sapiens_hsa047440.97281372
53Cardiac muscle contraction_Homo sapiens_hsa042600.95003919
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93734697
55Vitamin B6 metabolism_Homo sapiens_hsa007500.90583934
56Adherens junction_Homo sapiens_hsa045200.89905709
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89504001
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.86660445
59Endometrial cancer_Homo sapiens_hsa052130.84880105
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.84848234
61Oocyte meiosis_Homo sapiens_hsa041140.83250400
62Pancreatic secretion_Homo sapiens_hsa049720.81270041
63Endocytosis_Homo sapiens_hsa041440.79222009
64Hippo signaling pathway_Homo sapiens_hsa043900.79218639
65Thyroid hormone synthesis_Homo sapiens_hsa049180.79029275
66Insulin signaling pathway_Homo sapiens_hsa049100.78577628
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77888950
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77805896
69MAPK signaling pathway_Homo sapiens_hsa040100.74854418
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73886366
71Notch signaling pathway_Homo sapiens_hsa043300.73839772
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.73743671
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72237342
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71869499
75Non-small cell lung cancer_Homo sapiens_hsa052230.71745586
76Choline metabolism in cancer_Homo sapiens_hsa052310.71487335
77Renal cell carcinoma_Homo sapiens_hsa052110.70697588
78Collecting duct acid secretion_Homo sapiens_hsa049660.69948737
79Glucagon signaling pathway_Homo sapiens_hsa049220.69493147
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69044118
81Wnt signaling pathway_Homo sapiens_hsa043100.67773857
82Rap1 signaling pathway_Homo sapiens_hsa040150.67537395
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66600639
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65210439
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65055982
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64214228
87Bile secretion_Homo sapiens_hsa049760.62389890
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61022576
89Vibrio cholerae infection_Homo sapiens_hsa051100.60367431
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.59965565
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59846717
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58876654
93Thyroid cancer_Homo sapiens_hsa052160.58710389
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58299253
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58184733
96Biosynthesis of amino acids_Homo sapiens_hsa012300.57286866
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55981750
98Ras signaling pathway_Homo sapiens_hsa040140.55021512
99Colorectal cancer_Homo sapiens_hsa052100.54709276
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54648958
101Inositol phosphate metabolism_Homo sapiens_hsa005620.53590690
102Bladder cancer_Homo sapiens_hsa052190.51736357
103Prion diseases_Homo sapiens_hsa050200.51037613
104Focal adhesion_Homo sapiens_hsa045100.50957640
105Tight junction_Homo sapiens_hsa045300.50938962
106Chronic myeloid leukemia_Homo sapiens_hsa052200.50541755
107Pancreatic cancer_Homo sapiens_hsa052120.50503048
108Prolactin signaling pathway_Homo sapiens_hsa049170.49680450
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47464320
110Proteoglycans in cancer_Homo sapiens_hsa052050.47388357
111Platelet activation_Homo sapiens_hsa046110.46739118
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46152622
113Chemokine signaling pathway_Homo sapiens_hsa040620.45860459
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45827754
115AMPK signaling pathway_Homo sapiens_hsa041520.45723378
116Insulin resistance_Homo sapiens_hsa049310.45186513
117Amoebiasis_Homo sapiens_hsa051460.43975003

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