DCST1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with a domain similar to one found in dendritic cells (PMID:11169400) which play a key role in antigen processing and display for immune responses. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)6.52363151
2motile cilium assembly (GO:0044458)6.33608417
3acrosome reaction (GO:0007340)6.30259169
4acrosome assembly (GO:0001675)6.22621785
5sperm motility (GO:0030317)6.09614954
6axonemal dynein complex assembly (GO:0070286)6.07165256
7multicellular organism reproduction (GO:0032504)5.89887422
8fusion of sperm to egg plasma membrane (GO:0007342)5.76785371
9cell wall macromolecule metabolic process (GO:0044036)5.08896890
10cell wall macromolecule catabolic process (GO:0016998)5.08896890
11epithelial cilium movement (GO:0003351)5.07002556
12L-serine metabolic process (GO:0006563)5.00411650
13cilium movement (GO:0003341)4.69860646
14sperm-egg recognition (GO:0035036)4.69620219
15reproduction (GO:0000003)4.55955169
16plasma membrane fusion (GO:0045026)4.50483159
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.39744106
18cell-cell recognition (GO:0009988)4.20550467
19positive regulation of mitochondrial fission (GO:0090141)4.15108005
20regulation of activation of Janus kinase activity (GO:0010533)4.12101692
21protein neddylation (GO:0045116)4.06710074
22protein localization to cilium (GO:0061512)3.91635980
23single fertilization (GO:0007338)3.87473548
24cellular ketone body metabolic process (GO:0046950)3.85145304
25spermatid development (GO:0007286)3.84568596
26piRNA metabolic process (GO:0034587)3.80814782
27ncRNA 3-end processing (GO:0043628)3.77411656
28regulation of glycogen (starch) synthase activity (GO:2000465)3.69012652
29sperm capacitation (GO:0048240)3.63426291
30regulation of cilium movement (GO:0003352)3.62843323
31cysteine metabolic process (GO:0006534)3.62588603
32binding of sperm to zona pellucida (GO:0007339)3.61507587
33adenosine metabolic process (GO:0046085)3.58987181
34microtubule depolymerization (GO:0007019)3.57338071
35G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.51830218
36protein polyglutamylation (GO:0018095)3.48918782
37serine family amino acid biosynthetic process (GO:0009070)3.47113972
38protein insertion into membrane (GO:0051205)3.44977236
39ketone body metabolic process (GO:1902224)3.44026686
40response to redox state (GO:0051775)3.44013692
41short-term memory (GO:0007614)3.39213234
42regulation of dendritic cell antigen processing and presentation (GO:0002604)3.34088220
43RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)3.32928983
44regulation of collateral sprouting (GO:0048670)3.31491321
45centriole assembly (GO:0098534)3.29291202
46ventricular system development (GO:0021591)3.25330645
47sulfur amino acid catabolic process (GO:0000098)3.22654468
48biotin metabolic process (GO:0006768)3.22454552
49DNA methylation involved in gamete generation (GO:0043046)3.19209883
50calcium ion-dependent exocytosis (GO:0017156)3.15013917
51male meiosis (GO:0007140)3.13940773
52base-excision repair, AP site formation (GO:0006285)3.12805660
53detection of bacterium (GO:0016045)3.10594302
54establishment of mitochondrion localization (GO:0051654)3.10382523
55phenol-containing compound catabolic process (GO:0019336)3.06959204
56superoxide anion generation (GO:0042554)3.06303650
57G-protein coupled receptor internalization (GO:0002031)3.04777745
58inner ear receptor stereocilium organization (GO:0060122)3.01923220
59organic cation transport (GO:0015695)3.01702764
60negative regulation of microtubule depolymerization (GO:0007026)3.00650677
61daunorubicin metabolic process (GO:0044597)2.99788137
62polyketide metabolic process (GO:0030638)2.99788137
63doxorubicin metabolic process (GO:0044598)2.99788137
64regulation of microtubule depolymerization (GO:0031114)2.99368646
65cell migration in hindbrain (GO:0021535)2.98755128
66regulation of mitochondrial fission (GO:0090140)2.98382680
67sensory perception of smell (GO:0007608)2.96750587
68serine family amino acid metabolic process (GO:0009069)2.96335474
69detection of other organism (GO:0098543)2.95547494
70mitochondrial fusion (GO:0008053)2.95139998
71fertilization (GO:0009566)2.92846680
72postsynaptic membrane organization (GO:0001941)2.91950849
73regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.89990615
74body morphogenesis (GO:0010171)2.89129643
75transmission of nerve impulse (GO:0019226)2.87705726
76auditory receptor cell stereocilium organization (GO:0060088)2.84670014
77behavioral response to nicotine (GO:0035095)2.83584276
78neuron cell-cell adhesion (GO:0007158)2.82227318
79drinking behavior (GO:0042756)2.78081168
80L-amino acid import (GO:0043092)2.77434320
81positive regulation of cellular amide metabolic process (GO:0034250)2.77017002
82spermatogenesis (GO:0007283)2.75344554
83serine family amino acid catabolic process (GO:0009071)2.75167978
84male gamete generation (GO:0048232)2.74033660
85detection of light stimulus involved in sensory perception (GO:0050962)2.72358067
86detection of light stimulus involved in visual perception (GO:0050908)2.72358067
87intraciliary transport (GO:0042073)2.71563536
88opioid receptor signaling pathway (GO:0038003)2.70034872
89startle response (GO:0001964)2.69737964
90axoneme assembly (GO:0035082)2.69321994
91thalamus development (GO:0021794)2.68901632
92polyol transport (GO:0015791)2.67785239
93sulfate transmembrane transport (GO:1902358)2.66260049
94glucocorticoid receptor signaling pathway (GO:0042921)2.66216954
95presynaptic membrane assembly (GO:0097105)2.66005257
96cilium assembly (GO:0042384)2.64699990
97embryonic body morphogenesis (GO:0010172)2.63551457
98glyoxylate metabolic process (GO:0046487)2.62644310
99righting reflex (GO:0060013)2.59457336
100microtubule bundle formation (GO:0001578)2.58644841
101regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.57113316
102cell recognition (GO:0008037)2.55745599
103sulfate transport (GO:0008272)2.55263023
104cullin deneddylation (GO:0010388)2.55071900
105peptidyl-glutamic acid modification (GO:0018200)2.54877978
106cilium organization (GO:0044782)2.54150584
107negative regulation of cell aging (GO:0090344)2.53517250
108positive regulation of uterine smooth muscle contraction (GO:0070474)2.53226458
109gamete generation (GO:0007276)2.51922208
110mitochondrion transport along microtubule (GO:0047497)2.51876861
111establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.51876861
112glucocorticoid biosynthetic process (GO:0006704)2.51825185
113RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.50838450
114tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.50838450
115positive regulation of antigen processing and presentation (GO:0002579)2.50591003
116cytoplasmic microtubule organization (GO:0031122)2.50169274
117regulation of double-strand break repair via homologous recombination (GO:0010569)2.49070011
118mitochondrion distribution (GO:0048311)2.48747549
119protein-cofactor linkage (GO:0018065)2.48459490
120arginine catabolic process (GO:0006527)2.48339923
121tRNA processing (GO:0008033)2.47826002
122developmental pigmentation (GO:0048066)2.47758576
123neurotransmitter catabolic process (GO:0042135)2.47490879
124pyrimidine nucleobase catabolic process (GO:0006208)2.46770229
125layer formation in cerebral cortex (GO:0021819)2.46570085
126sleep (GO:0030431)2.45088394
127synaptonemal complex assembly (GO:0007130)2.44178848
128female gonad development (GO:0008585)2.44074942
129regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.43610957
1304-hydroxyproline metabolic process (GO:0019471)2.43139989
131cranial nerve morphogenesis (GO:0021602)2.42225394
132regulation of microtubule-based movement (GO:0060632)2.41631438
133cAMP catabolic process (GO:0006198)2.41437220
134positive regulation of guanylate cyclase activity (GO:0031284)2.40468126
135forebrain morphogenesis (GO:0048853)2.39239646
136dosage compensation (GO:0007549)2.38983677
137metallo-sulfur cluster assembly (GO:0031163)2.38215365
138iron-sulfur cluster assembly (GO:0016226)2.38215365
139negative regulation of T cell mediated immunity (GO:0002710)2.38167738
140left/right pattern formation (GO:0060972)2.37230861
141left/right axis specification (GO:0070986)2.36985962
142cyclic nucleotide catabolic process (GO:0009214)2.36613154
143negative regulation of mast cell activation (GO:0033004)2.35792527
144RNA localization (GO:0006403)2.35711706
145negative regulation of microtubule polymerization or depolymerization (GO:0031111)2.35546108
146tRNA modification (GO:0006400)2.35225790
147axon extension (GO:0048675)2.34937649
148nucleoside transmembrane transport (GO:1901642)2.34559299
149reflex (GO:0060004)2.34513708
150urinary tract smooth muscle contraction (GO:0014848)2.34359396
151negative regulation of transcription regulatory region DNA binding (GO:2000678)2.34333281
152regulation of timing of cell differentiation (GO:0048505)2.33703685
153cell proliferation in forebrain (GO:0021846)2.33243380
154protoporphyrinogen IX metabolic process (GO:0046501)2.33071265
155positive regulation of CREB transcription factor activity (GO:0032793)2.31883681
156calcium ion import (GO:0070509)2.31398871
157dendrite development (GO:0016358)2.31124565
158dentate gyrus development (GO:0021542)2.29996778
159positive regulation of monocyte chemotaxis (GO:0090026)2.29451379
160regulation of uterine smooth muscle contraction (GO:0070472)2.29278674
161detection of external biotic stimulus (GO:0098581)2.29186206
162vocalization behavior (GO:0071625)2.27397365
163sequestering of actin monomers (GO:0042989)2.27128407
164cell differentiation involved in metanephros development (GO:0072202)2.26513821
165cellular process involved in reproduction in multicellular organism (GO:0022412)2.25953957
166sulfur amino acid biosynthetic process (GO:0000097)2.25854837
167regulation of autophagic vacuole assembly (GO:2000785)2.24670100
168behavioral response to ethanol (GO:0048149)2.24150939
169nucleoside diphosphate catabolic process (GO:0009134)2.24095781
170photoreceptor cell maintenance (GO:0045494)2.22231643
171cellular component assembly involved in morphogenesis (GO:0010927)2.22120611
172energy homeostasis (GO:0097009)2.21989303
173detection of molecule of bacterial origin (GO:0032490)2.21894501
174mitochondrial fission (GO:0000266)2.21884983
175L-methionine biosynthetic process (GO:0071265)2.21801114
176amino acid salvage (GO:0043102)2.21801114
177L-methionine salvage (GO:0071267)2.21801114
178regulation of antigen processing and presentation (GO:0002577)2.20220691
179microtubule polymerization or depolymerization (GO:0031109)2.19735897
180positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.19625595

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.18194273
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.71972708
3GBX2_23144817_ChIP-Seq_PC3_Human3.60971774
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.37029320
5ZNF263_19887448_ChIP-Seq_K562_Human2.97595210
6CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.93739784
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.84514076
8ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.75261208
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55757442
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.52135719
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.48525199
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.43797747
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.36166016
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30150168
15VDR_22108803_ChIP-Seq_LS180_Human2.13356855
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.11778759
17PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09667897
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09125030
19CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.07845334
20PCGF2_27294783_Chip-Seq_NPCs_Mouse2.05523979
21SUZ12_27294783_Chip-Seq_NPCs_Mouse2.03106448
22NFE2_27457419_Chip-Seq_LIVER_Mouse1.99730610
23GABP_19822575_ChIP-Seq_HepG2_Human1.97394975
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96463350
25XRN2_22483619_ChIP-Seq_HELA_Human1.94085004
26TAF15_26573619_Chip-Seq_HEK293_Human1.93062769
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90563884
28TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.85388848
29ZNF274_21170338_ChIP-Seq_K562_Hela1.84071864
30NANOG_18555785_Chip-Seq_ESCs_Mouse1.80753336
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.79292977
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.77047472
33EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.77038130
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75798403
35SUZ12_18555785_Chip-Seq_ESCs_Mouse1.73557052
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73286209
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.72626504
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71766295
39P53_22387025_ChIP-Seq_ESCs_Mouse1.71765641
40STAT3_18555785_Chip-Seq_ESCs_Mouse1.70428891
41CTCF_27219007_Chip-Seq_Bcells_Human1.70217501
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.69722936
43P300_19829295_ChIP-Seq_ESCs_Human1.65516992
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65405871
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64496570
46E2F1_18555785_Chip-Seq_ESCs_Mouse1.64447992
47RNF2_27304074_Chip-Seq_NSC_Mouse1.64088075
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.63796631
49NMYC_18555785_Chip-Seq_ESCs_Mouse1.62098352
50CMYC_18555785_Chip-Seq_ESCs_Mouse1.61710881
51E2F1_20622854_ChIP-Seq_HELA_Human1.61043574
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60433564
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60401733
54PHF8_20622854_ChIP-Seq_HELA_Human1.59844968
55P300_18555785_Chip-Seq_ESCs_Mouse1.57983737
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57354150
57EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.57291973
58P68_20966046_ChIP-Seq_HELA_Human1.56634895
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55938700
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55725501
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.52198071
62SMAD4_21799915_ChIP-Seq_A2780_Human1.51551430
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.51445174
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.51323480
65REST_21632747_ChIP-Seq_MESCs_Mouse1.50969374
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50481918
67RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.50386809
68RUNX1_27457419_Chip-Seq_LIVER_Mouse1.50335210
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49475789
70SOX2_18555785_Chip-Seq_ESCs_Mouse1.49182659
71OCT4_18555785_Chip-Seq_ESCs_Mouse1.48387240
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.48301257
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.48279035
74TAL1_26923725_Chip-Seq_HPCs_Mouse1.47344345
75PU1_27457419_Chip-Seq_LIVER_Mouse1.45644148
76SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44411086
77ESRRB_18555785_Chip-Seq_ESCs_Mouse1.44234094
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43830134
79ZFX_18555785_Chip-Seq_ESCs_Mouse1.42644956
80KLF4_18555785_Chip-Seq_ESCs_Mouse1.42449568
81RNF2_27304074_Chip-Seq_ESCs_Mouse1.40848183
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.38869602
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38345514
84KDM2B_26808549_Chip-Seq_REH_Human1.37941072
85ER_23166858_ChIP-Seq_MCF-7_Human1.37840496
86SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.37796553
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37449571
88JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36729266
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36517266
90* FOXP1_21924763_ChIP-Seq_HESCs_Human1.35580534
91SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.35345512
92SMAD1_18555785_Chip-Seq_ESCs_Mouse1.35339049
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35037502
94BCL6_27268052_Chip-Seq_Bcells_Human1.34891857
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34036340
96OCT4_20526341_ChIP-Seq_ESCs_Human1.33755392
97CTCF_20526341_ChIP-Seq_ESCs_Human1.33748490
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33130599
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33130599
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32640224
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32605219
102CTCF_18555785_Chip-Seq_ESCs_Mouse1.31586013
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31257524
104SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31206442
105RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29803836
106EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29803836
107CRX_20693478_ChIP-Seq_RETINA_Mouse1.29508373
108ERA_21632823_ChIP-Seq_H3396_Human1.29347750
109DROSHA_22980978_ChIP-Seq_HELA_Human1.29042238
110PIAS1_25552417_ChIP-Seq_VCAP_Human1.28877478
111BP1_19119308_ChIP-ChIP_Hs578T_Human1.28453815
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28085038
113RXRA_24833708_ChIP-Seq_LIVER_Mouse1.27781766
114SMAD_19615063_ChIP-ChIP_OVARY_Human1.27462227
115RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27386322
116OCT4_21477851_ChIP-Seq_ESCs_Mouse1.27185623
117SMC4_20622854_ChIP-Seq_HELA_Human1.27172979
118MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26763773
119SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24317035
120MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24270653
121P53_21459846_ChIP-Seq_SAOS-2_Human1.22003270
122SMAD3_21741376_ChIP-Seq_EPCs_Human1.20829617
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20790973
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20502291
125MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.20426874
126FUS_26573619_Chip-Seq_HEK293_Human1.20392405
127KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20375269
128CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20005484
129REST_18959480_ChIP-ChIP_MESCs_Mouse1.19828127
130GATA3_21878914_ChIP-Seq_MCF-7_Human1.19499993
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18965217
132TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18759185
133DCP1A_22483619_ChIP-Seq_HELA_Human1.18712444
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18641422
135YY1_22570637_ChIP-Seq_MALME-3M_Human1.17786131
136CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17501827
137E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17439003
138SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17012109
139CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17009618
140RARA_24833708_ChIP-Seq_LIVER_Mouse1.16436500
141IRF1_19129219_ChIP-ChIP_H3396_Human1.16358432
142KDM5A_27292631_Chip-Seq_BREAST_Human1.16315593
143TCF4_23295773_ChIP-Seq_U87_Human1.15780544
144TTF2_22483619_ChIP-Seq_HELA_Human1.15381098
145SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.15101515
146EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14730808
147AR_25329375_ChIP-Seq_VCAP_Human1.14580733
148KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14541171
149THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14305265
150HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14215978
151ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13982256
152SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13396775
153MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12790149
154AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12725113
155IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11750916
156CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10706579
157MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10517649
158* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10432549
159* TP53_22127205_ChIP-Seq_IMR90_Human1.09625384
160BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09417456
161SRF_21415370_ChIP-Seq_HL-1_Mouse1.08979766
162SA1_27219007_Chip-Seq_ERYTHROID_Human1.08568222
163RUNX2_22187159_ChIP-Seq_PCA_Human1.08301405
164IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08270082
165STAT1_17558387_ChIP-Seq_HELA_Human1.08111705
166STAT3_23295773_ChIP-Seq_U87_Human1.07067801
167* RAC3_21632823_ChIP-Seq_H3396_Human1.06985069
168* LXR_22292898_ChIP-Seq_THP-1_Human1.06288465
169BCOR_27268052_Chip-Seq_Bcells_Human1.06230408
170TAF2_19829295_ChIP-Seq_ESCs_Human1.06054287
171CIITA_25753668_ChIP-Seq_RAJI_Human1.04938469
172EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04674222
173HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02285807
174* ELF1_20517297_ChIP-Seq_JURKAT_Human1.02271335
175* RARB_24833708_ChIP-Seq_LIVER_Mouse1.00764837
176TET1_21490601_ChIP-Seq_MESCs_Mouse0.99642704
177SA1_27219007_Chip-Seq_Bcells_Human0.99456664
178PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97644633
179CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96288595
180* CREB1_26743006_Chip-Seq_LNCaP_Human0.92920213
181FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92692580
182NANOG_20526341_ChIP-Seq_ESCs_Human0.92408720
183E2F1_17053090_ChIP-ChIP_MCF-7_Human0.91814104
184RACK7_27058665_Chip-Seq_MCF-7_Human0.90917644
185ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88291269
186ELK4_26923725_Chip-Seq_MESODERM_Mouse0.88182489
187CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86328650
188* TP53_22573176_ChIP-Seq_HFKS_Human0.86271735
189RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85327395
190ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84112335

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.86192874
2MP0006292_abnormal_olfactory_placode3.95187534
3MP0001188_hyperpigmentation3.43850954
4MP0010030_abnormal_orbit_morphology3.21712053
5MP0002249_abnormal_larynx_morphology2.86133106
6MP0005646_abnormal_pituitary_gland2.69993938
7MP0002653_abnormal_ependyma_morphology2.60932047
8MP0003880_abnormal_central_pattern2.43914952
9MP0002102_abnormal_ear_morphology2.43365986
10MP0001986_abnormal_taste_sensitivity2.41466922
11MP0003698_abnormal_male_reproductive2.38428981
12MP0002876_abnormal_thyroid_physiology2.35587954
13MP0005645_abnormal_hypothalamus_physiol2.24995288
14MP0001486_abnormal_startle_reflex2.22498344
15MP0001984_abnormal_olfaction2.21338031
16MP0003878_abnormal_ear_physiology2.20339438
17MP0005377_hearing/vestibular/ear_phenot2.20339438
18MP0002638_abnormal_pupillary_reflex2.13456606
19MP0000015_abnormal_ear_pigmentation2.08211410
20MP0005423_abnormal_somatic_nervous2.06528535
21MP0005365_abnormal_bile_salt2.04879424
22MP0005171_absent_coat_pigmentation1.99726231
23MP0003136_yellow_coat_color1.96190933
24MP0008877_abnormal_DNA_methylation1.92826622
25MP0001968_abnormal_touch/_nociception1.91743036
26MP0003806_abnormal_nucleotide_metabolis1.90703589
27MP0002736_abnormal_nociception_after1.88842449
28MP0000566_synostosis1.88298617
29MP0008875_abnormal_xenobiotic_pharmacok1.83962984
30MP0009046_muscle_twitch1.79268012
31MP0010386_abnormal_urinary_bladder1.78675948
32MP0001929_abnormal_gametogenesis1.75991400
33MP0000778_abnormal_nervous_system1.75319960
34MP0004381_abnormal_hair_follicle1.72433724
35MP0002277_abnormal_respiratory_mucosa1.69167547
36MP0008789_abnormal_olfactory_epithelium1.68125731
37MP0005083_abnormal_biliary_tract1.65724399
38MP0009745_abnormal_behavioral_response1.60710862
39MP0004742_abnormal_vestibular_system1.58879403
40MP0005451_abnormal_body_composition1.57681596
41MP0009697_abnormal_copulation1.56619753
42MP0005174_abnormal_tail_pigmentation1.54031953
43MP0005670_abnormal_white_adipose1.52356931
44MP0005499_abnormal_olfactory_system1.50436881
45MP0005394_taste/olfaction_phenotype1.50436881
46MP0008995_early_reproductive_senescence1.49627077
47MP0006276_abnormal_autonomic_nervous1.49583860
48MP0005379_endocrine/exocrine_gland_phen1.48019480
49MP0005409_darkened_coat_color1.44561830
50MP0002272_abnormal_nervous_system1.43182754
51MP0002282_abnormal_trachea_morphology1.42753966
52MP0003122_maternal_imprinting1.42245304
53MP0000955_abnormal_spinal_cord1.37336423
54MP0002572_abnormal_emotion/affect_behav1.36286769
55MP0000049_abnormal_middle_ear1.32643988
56MP0005551_abnormal_eye_electrophysiolog1.32308225
57MP0003879_abnormal_hair_cell1.28280719
58MP0005360_urolithiasis1.27769184
59MP0010234_abnormal_vibrissa_follicle1.27462808
60MP0001963_abnormal_hearing_physiology1.27271378
61MP0000678_abnormal_parathyroid_gland1.27199355
62MP0003635_abnormal_synaptic_transmissio1.27178262
63MP0002557_abnormal_social/conspecific_i1.26990419
64MP0002067_abnormal_sensory_capabilities1.26929159
65MP0001764_abnormal_homeostasis1.26838077
66MP0004782_abnormal_surfactant_physiolog1.24746799
67MP0005248_abnormal_Harderian_gland1.22785555
68MP0001529_abnormal_vocalization1.22457098
69MP0000026_abnormal_inner_ear1.21912266
70MP0002210_abnormal_sex_determination1.21594415
71MP0001501_abnormal_sleep_pattern1.20103874
72MP0002735_abnormal_chemical_nociception1.19112359
73MP0003123_paternal_imprinting1.17162865
74MP0003755_abnormal_palate_morphology1.16053117
75MP0000681_abnormal_thyroid_gland1.15460182
76MP0004233_abnormal_muscle_weight1.15155376
77MP0002234_abnormal_pharynx_morphology1.15115247
78MP0004264_abnormal_extraembryonic_tissu1.15042810
79MP0003787_abnormal_imprinting1.14672253
80MP0002064_seizures1.14669369
81MP0003941_abnormal_skin_development1.10465800
82MP0008058_abnormal_DNA_repair1.09905757
83MP0002148_abnormal_hypersensitivity_rea1.08329937
84MP0002161_abnormal_fertility/fecundity1.06576815
85MP0002063_abnormal_learning/memory/cond1.06373417
86MP0005253_abnormal_eye_physiology1.03891044
87MP0010094_abnormal_chromosome_stability1.03547730
88MP0001502_abnormal_circadian_rhythm1.03435904
89MP0001835_abnormal_antigen_presentation1.02512685
90MP0005075_abnormal_melanosome_morpholog1.02221408
91MP0003937_abnormal_limbs/digits/tail_de1.02084316
92MP0001790_abnormal_immune_system1.01358947
93MP0005387_immune_system_phenotype1.01358947
94MP0005671_abnormal_response_to1.01073478
95MP0000003_abnormal_adipose_tissue0.98571551
96MP0001919_abnormal_reproductive_system0.98527904
97MP0003724_increased_susceptibility_to0.97341482
98MP0004130_abnormal_muscle_cell0.96679949
99MP0005623_abnormal_meninges_morphology0.95225600
100MP0002163_abnormal_gland_morphology0.94812074
101MP0002882_abnormal_neuron_morphology0.94290985
102MP0001324_abnormal_eye_pigmentation0.94217626
103MP0002928_abnormal_bile_duct0.94000510
104MP0009785_altered_susceptibility_to0.92947400
105MP0000372_irregular_coat_pigmentation0.92852877
106MP0009764_decreased_sensitivity_to0.92215508
107MP0004859_abnormal_synaptic_plasticity0.90445660
108MP0001293_anophthalmia0.88679020
109MP0000631_abnormal_neuroendocrine_gland0.86555983
110MP0001905_abnormal_dopamine_level0.86519563
111MP0000013_abnormal_adipose_tissue0.85560936
112MP0004145_abnormal_muscle_electrophysio0.85252292
113MP0002938_white_spotting0.85166765
114MP0005332_abnormal_amino_acid0.84843023
115MP0005084_abnormal_gallbladder_morpholo0.84740669
116MP0003693_abnormal_embryo_hatching0.83787245
117MP0003868_abnormal_feces_composition0.83400396
118MP0001664_abnormal_digestion0.82063152
119MP0003890_abnormal_embryonic-extraembry0.82033621
120MP0001440_abnormal_grooming_behavior0.81788928
121MP0000569_abnormal_digit_pigmentation0.81430889
122MP0003567_abnormal_fetal_cardiomyocyte0.81015909
123MP0002095_abnormal_skin_pigmentation0.80787310
124MP0001145_abnormal_male_reproductive0.80124739
125MP0000534_abnormal_ureter_morphology0.79492836
126MP0002734_abnormal_mechanical_nocicepti0.79486570
127MP0000647_abnormal_sebaceous_gland0.79422754
128MP0000653_abnormal_sex_gland0.79194575
129MP0009780_abnormal_chondrocyte_physiolo0.78958168
130MP0003315_abnormal_perineum_morphology0.78631811
131MP0003942_abnormal_urinary_system0.78391654
132MP0005501_abnormal_skin_physiology0.77827163
133MP0004142_abnormal_muscle_tone0.77069618
134MP0002132_abnormal_respiratory_system0.76839575
135MP0001485_abnormal_pinna_reflex0.75798631
136MP0004133_heterotaxia0.75063770
137MP0000358_abnormal_cell_content/0.73382078
138MP0008932_abnormal_embryonic_tissue0.73378469
139MP0002152_abnormal_brain_morphology0.73297124
140MP0002419_abnormal_innate_immunity0.72983195
141MP0002116_abnormal_craniofacial_bone0.72554423
142MP0003861_abnormal_nervous_system0.72203828
143MP0002160_abnormal_reproductive_system0.71525264
144MP0002233_abnormal_nose_morphology0.71323357
145MP0003011_delayed_dark_adaptation0.70918709
146MP0008260_abnormal_autophagy0.68536185
147MP0000427_abnormal_hair_cycle0.67791730
148MP0004147_increased_porphyrin_level0.67566270
149MP0008569_lethality_at_weaning0.67551739
150MP0005025_abnormal_response_to0.64217656
151MP0002752_abnormal_somatic_nervous0.63583107
152MP0005000_abnormal_immune_tolerance0.63135445
153MP0002184_abnormal_innervation0.60289741
154MP0003786_premature_aging0.59757756
155MP0005389_reproductive_system_phenotype0.59589698
156MP0003763_abnormal_thymus_physiology0.58913340

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)8.23451103
2Absent/shortened dynein arms (HP:0200106)8.23451103
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.71573771
4Abnormal respiratory epithelium morphology (HP:0012253)6.11387539
5Abnormal respiratory motile cilium morphology (HP:0005938)6.11387539
6Abnormal respiratory motile cilium physiology (HP:0012261)5.67402579
7Chromosomal breakage induced by crosslinking agents (HP:0003221)5.60911535
8Abnormal ciliary motility (HP:0012262)5.32128123
9Chromsome breakage (HP:0040012)4.76509768
10Duplicated collecting system (HP:0000081)4.45722180
11Rhinitis (HP:0012384)4.21640630
12Deep palmar crease (HP:0006191)3.94654137
13Abnormality of the renal collecting system (HP:0004742)3.84386751
14Facial hemangioma (HP:0000329)3.51156864
15Abnormality of DNA repair (HP:0003254)3.27410915
16Febrile seizures (HP:0002373)3.26939756
17Bony spicule pigmentary retinopathy (HP:0007737)3.20377881
18Abnormality of the aortic arch (HP:0012303)3.10270036
19Nephronophthisis (HP:0000090)2.99294475
20Facial cleft (HP:0002006)2.98124715
21Aplasia/Hypoplasia of the uvula (HP:0010293)2.90880945
22Hyperglycinemia (HP:0002154)2.88221485
23Ectopic kidney (HP:0000086)2.85304185
24Retinal dysplasia (HP:0007973)2.82194057
25Neonatal respiratory distress (HP:0002643)2.80686713
26Capillary hemangiomas (HP:0005306)2.80573757
27Decreased central vision (HP:0007663)2.71554551
28Short tibia (HP:0005736)2.64733242
29Abnormality of the renal medulla (HP:0100957)2.63999830
30Optic neuritis (HP:0100653)2.63724861
31Retrobulbar optic neuritis (HP:0100654)2.63724861
32Abnormality of the preputium (HP:0100587)2.63173290
33Meckel diverticulum (HP:0002245)2.63016032
34Clubbing of toes (HP:0100760)2.61461789
35Pancreatic cysts (HP:0001737)2.60789335
36Congenital primary aphakia (HP:0007707)2.60526629
37Recurrent sinusitis (HP:0011108)2.59203691
38Tubulointerstitial nephritis (HP:0001970)2.57514911
39Impulsivity (HP:0100710)2.56540072
40Fibular aplasia (HP:0002990)2.55333571
41Chronic bronchitis (HP:0004469)2.55068011
42Aplasia/Hypoplasia of the tibia (HP:0005772)2.54612880
43Abnormality of the ileum (HP:0001549)2.53043182
44Limb hypertonia (HP:0002509)2.51345049
45Abnormality of the labia minora (HP:0012880)2.49176393
46Focal motor seizures (HP:0011153)2.47642526
47Duplication of thumb phalanx (HP:0009942)2.42696740
48Molar tooth sign on MRI (HP:0002419)2.41611247
49Bronchiectasis (HP:0002110)2.41327217
50Genetic anticipation (HP:0003743)2.33874430
51Abnormality of dental color (HP:0011073)2.32236873
52Abnormal gallbladder physiology (HP:0012438)2.31119140
53Cholecystitis (HP:0001082)2.31119140
54Curly hair (HP:0002212)2.30194830
55Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.27656631
56Tachypnea (HP:0002789)2.26623609
57Tubular atrophy (HP:0000092)2.25867032
58Dyschromatopsia (HP:0007641)2.25672701
59Hyperglycinuria (HP:0003108)2.22225310
60Cholelithiasis (HP:0001081)2.21287687
61Septo-optic dysplasia (HP:0100842)2.21054274
62Optic nerve hypoplasia (HP:0000609)2.21037069
63Abnormality of the dental pulp (HP:0006479)2.19972785
64Submucous cleft hard palate (HP:0000176)2.19906612
65Congenital sensorineural hearing impairment (HP:0008527)2.19725710
66Infertility (HP:0000789)2.18891751
67Medial flaring of the eyebrow (HP:0010747)2.17347727
68Abnormality of the renal cortex (HP:0011035)2.16112395
69Abnormality of chromosome stability (HP:0003220)2.14374831
70Poikiloderma (HP:0001029)2.12640488
71Concave nail (HP:0001598)2.07613757
72Abnormality of incisor morphology (HP:0011063)2.07430910
73Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07373929
74Parakeratosis (HP:0001036)2.06037211
75Epileptic encephalopathy (HP:0200134)2.05661792
76Pancreatic fibrosis (HP:0100732)2.04844281
77Hyperthyroidism (HP:0000836)2.03840751
78Increased IgM level (HP:0003496)2.02267368
79Fetal akinesia sequence (HP:0001989)2.00325233
80Microretrognathia (HP:0000308)2.00078120
81Broad-based gait (HP:0002136)1.99731828
82Upper limb muscle weakness (HP:0003484)1.98476055
83Type 2 muscle fiber atrophy (HP:0003554)1.97963391
84True hermaphroditism (HP:0010459)1.97736549
85Microvesicular hepatic steatosis (HP:0001414)1.97391940
86Aplasia/Hypoplasia of the patella (HP:0006498)1.96709389
87Pendular nystagmus (HP:0012043)1.95955228
88Glossoptosis (HP:0000162)1.95750513
89White forelock (HP:0002211)1.95102150
90Muscle fiber atrophy (HP:0100295)1.94371384
91Absent eyebrow (HP:0002223)1.92917657
92Poor coordination (HP:0002370)1.91084580
93Delayed myelination (HP:0012448)1.89257539
94Bilateral sensorineural hearing impairment (HP:0008619)1.88950470
95Hypergonadotropic hypogonadism (HP:0000815)1.88933075
96Abnormal hair whorl (HP:0010721)1.88796833
97Congenital stationary night blindness (HP:0007642)1.88702944
98Sclerocornea (HP:0000647)1.88594167
99Abnormal gallbladder morphology (HP:0012437)1.88391903
100Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.88093678
101Prostate neoplasm (HP:0100787)1.87953214
102Conical tooth (HP:0000698)1.87525605
103Aplasia/Hypoplasia of the fibula (HP:0006492)1.87386627
104Renal dysplasia (HP:0000110)1.87037661
105Abnormality of the costochondral junction (HP:0000919)1.87036920
106Rib fusion (HP:0000902)1.86404004
107Patchy hypopigmentation of hair (HP:0011365)1.83748645
108Atelectasis (HP:0100750)1.83040365
109Aplasia/hypoplasia of the humerus (HP:0006507)1.81881951
110Orchitis (HP:0100796)1.81571037
111Abnormal rod and cone electroretinograms (HP:0008323)1.81373826
112Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81266480
113Popliteal pterygium (HP:0009756)1.80313612
114Osteomalacia (HP:0002749)1.80129078
115Reticulocytopenia (HP:0001896)1.80125696
116Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79444289
117Short humerus (HP:0005792)1.78245229
118Hyperventilation (HP:0002883)1.78207696
119Patellar aplasia (HP:0006443)1.78141950
120Glomerulopathy (HP:0100820)1.78022512
121Abnormal spermatogenesis (HP:0008669)1.77761932
122Nephroblastoma (Wilms tumor) (HP:0002667)1.77657017
123Genital tract atresia (HP:0001827)1.77314682
124Abnormality of serine family amino acid metabolism (HP:0010894)1.76376326
125Abnormality of glycine metabolism (HP:0010895)1.76376326
126Severe visual impairment (HP:0001141)1.76296064
127Broad distal phalanx of finger (HP:0009836)1.75759704
128Renal cortical cysts (HP:0000803)1.75710668
129Overriding aorta (HP:0002623)1.75288339
130Myokymia (HP:0002411)1.74955264
131Vaginal atresia (HP:0000148)1.74447942
132Hypoplasia of the brainstem (HP:0002365)1.74365291
133Aplasia/Hypoplasia of the brainstem (HP:0007362)1.74365291
134Fair hair (HP:0002286)1.73815902
135Nasal polyposis (HP:0100582)1.73702137
136Chronic hepatic failure (HP:0100626)1.73194954
137Progressive cerebellar ataxia (HP:0002073)1.72932218
138Abnormality of the lower motor neuron (HP:0002366)1.71879364
139Lip pit (HP:0100267)1.71642607
140Hyperammonemia (HP:0001987)1.71563438
141Attenuation of retinal blood vessels (HP:0007843)1.71200107
142High anterior hairline (HP:0009890)1.71136649
143Cystic liver disease (HP:0006706)1.70591574
144Hypothermia (HP:0002045)1.70017798
145Prolonged partial thromboplastin time (HP:0003645)1.69774085
146Absent thumb (HP:0009777)1.69650154
147Chronic sinusitis (HP:0011109)1.69436736
148Astigmatism (HP:0000483)1.69125898
149Aplasia/Hypoplasia of the lens (HP:0008063)1.67958820
150Embryonal renal neoplasm (HP:0011794)1.67911007
151Polyphagia (HP:0002591)1.66044524
152Tubulointerstitial abnormality (HP:0001969)1.65692063
153Nephrogenic diabetes insipidus (HP:0009806)1.65644600
154Oligohydramnios (HP:0001562)1.65631463
155Abnormality of molar morphology (HP:0011070)1.65512398
156Abnormality of molar (HP:0011077)1.65512398
157Abnormality of the carotid arteries (HP:0005344)1.65406263
158Renovascular hypertension (HP:0100817)1.65361582
159Abnormality of the gallbladder (HP:0005264)1.65113253
160Keratitis (HP:0000491)1.64676873
161Aplasia involving forearm bones (HP:0009822)1.64343499
162Absent forearm bone (HP:0003953)1.64343499
163Supernumerary spleens (HP:0009799)1.63689607
164Heterotopia (HP:0002282)1.63609304
165Abnormality of the nasal septum (HP:0000419)1.63331522
166Abnormality of dentin (HP:0010299)1.63315041
167Small intestinal stenosis (HP:0012848)1.62879640
168Duodenal stenosis (HP:0100867)1.62879640
169Recurrent otitis media (HP:0000403)1.62742602
170Alveolar cell carcinoma (HP:0006519)1.61903383
171Anhidrosis (HP:0000970)1.61726310
172Stage 5 chronic kidney disease (HP:0003774)1.59751988
173Protruding tongue (HP:0010808)1.58354940
174Gait imbalance (HP:0002141)1.58172602
175Azoospermia (HP:0000027)1.57937029
176Recurrent abscess formation (HP:0002722)1.57843724
177Abnormal drinking behavior (HP:0030082)1.57394144
178Polydipsia (HP:0001959)1.57394144
179Obstructive lung disease (HP:0006536)1.57015650
180Chronic obstructive pulmonary disease (HP:0006510)1.57015650
181Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.54860707
182Abnormality of midbrain morphology (HP:0002418)1.54832899

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.26188848
2STK163.09632438
3TNIK2.78343214
4INSRR2.78270376
5EPHA22.69381579
6PDK42.49413595
7PDK32.49413595
8CAMKK22.43524985
9TXK2.41976930
10MAP3K142.34462661
11IRAK32.30640976
12BCKDK2.21465429
13CAMKK12.03816539
14SIK32.01554374
15NUAK11.97791376
16ZAK1.87790173
17ADRBK21.87268104
18DYRK31.86070865
19LIMK11.86027452
20EIF2AK21.84017123
21TNK21.81580185
22MAP2K71.79272988
23STK38L1.78486717
24GRK11.67134788
25NEK61.61612865
26IRAK41.60112892
27PDK21.58270932
28NTRK31.57425979
29NLK1.55851869
30CDC71.55177418
31TYRO31.54723784
32PRPF4B1.50530848
33AKT31.49640211
34RPS6KA41.44086930
35DYRK21.43482898
36NTRK21.41513729
37BMPR1B1.40414682
38MST1R1.39573851
39WNK41.37327101
40SGK21.32924164
41PRKD31.31973079
42TRIM281.31676300
43STK391.31477738
44MUSK1.29576963
45LATS11.25136856
46MINK11.22817582
47EIF2AK11.22131444
48BMPR21.21105748
49STK381.18335758
50NEK21.16855217
51MAP3K41.16433858
52YES11.15444448
53CHEK21.14998751
54PKN11.14589082
55TTK1.13146697
56IRAK11.11754026
57BLK1.09631137
58CLK11.07042773
59IRAK21.06690183
60MAPK131.06236381
61PTK2B1.05563018
62TEC1.05180766
63TSSK61.05140083
64GRK71.03621858
65MKNK21.01424620
66RIPK40.94607334
67MET0.91294070
68SGK4940.91047588
69SGK2230.91047588
70IKBKE0.88621462
71SIK20.87679917
72MST40.87470946
73RPS6KA50.83528002
74PLK40.83465739
75WEE10.83116742
76PTK60.82044803
77CDK140.81933938
78MAP3K60.81412057
79CDK30.79564241
80PAK30.79097764
81FRK0.79006824
82TESK10.78415559
83PLK10.78394345
84BRD40.76921571
85NEK10.76667159
86PRKCE0.76601952
87CDK70.76560431
88BRSK10.74479579
89PLK20.74164295
90CCNB10.74047277
91EPHA40.73347380
92MARK10.73193569
93PINK10.71491932
94NME20.70751655
95OXSR10.70685756
96PKN20.70341783
97RPS6KA20.68103888
98PRKCI0.67480269
99CDK80.65084727
100WNK10.64377592
101AURKA0.63902216
102PRKCZ0.63612536
103MAP3K120.63508844
104PRKCG0.61908731
105FGFR20.61855670
106TIE10.61049647
107CDK190.59346023
108DYRK1A0.59206309
109PRKCQ0.54868443
110SGK30.54762548
111CAMK40.54078485
112ICK0.53955440
113TLK10.53521509
114IKBKB0.53169966
115CAMK2A0.51743069
116CHEK10.50960306
117LYN0.50547230
118CSNK1A1L0.49773857
119SGK10.49494081
120MARK30.49217154
121MATK0.49123909
122CDK11A0.48700745
123CSNK1G30.47145707
124CDK180.46511472
125JAK10.45004582
126CSNK1G10.44895371
127MAPK150.44815240
128CDK150.43609620
129FLT30.43374594
130KIT0.42393091
131CDK20.42300685
132CSNK2A20.41797017
133BRAF0.40561965
134ADRBK10.40391608
135ERBB30.39739466
136TAOK10.39380883
137RPS6KA10.38031714
138RPS6KB10.37933885
139PDK10.36817969
140MAP3K80.35577817
141EPHB20.35421971
142PRKG10.34589227
143CSNK2A10.34463976
144GRK50.34264694
145FGR0.34157576
146MAPK70.33816938
147CSNK1E0.32806253
148BCR0.32800230
149RPS6KA60.32091764
150MKNK10.32009413
151CSNK1D0.31759545
152AKT10.31131598
153CAMK1G0.30946430
154SYK0.29152367
155SRPK10.28642940
156ATR0.28283204
157PBK0.27248794
158PRKACA0.26820871
159CAMK10.24753647
160PRKCA0.23826196
161PRKCD0.22885112

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041224.74628520
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.40759596
3Nicotine addiction_Homo sapiens_hsa050333.06841544
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.58961480
5Fanconi anemia pathway_Homo sapiens_hsa034602.46185760
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.35052506
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.30123523
8Taste transduction_Homo sapiens_hsa047422.09667282
9Morphine addiction_Homo sapiens_hsa050321.96825452
10Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.96196232
11Protein export_Homo sapiens_hsa030601.88269916
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84407279
13Linoleic acid metabolism_Homo sapiens_hsa005911.82021663
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.81131862
15Asthma_Homo sapiens_hsa053101.80743577
16Collecting duct acid secretion_Homo sapiens_hsa049661.77163895
17Phenylalanine metabolism_Homo sapiens_hsa003601.75626220
18Sphingolipid metabolism_Homo sapiens_hsa006001.75534537
19Olfactory transduction_Homo sapiens_hsa047401.71895100
20Autoimmune thyroid disease_Homo sapiens_hsa053201.70592052
21Ether lipid metabolism_Homo sapiens_hsa005651.70095641
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.69962249
23Rheumatoid arthritis_Homo sapiens_hsa053231.69886175
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.63455521
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57149373
26Arachidonic acid metabolism_Homo sapiens_hsa005901.55161010
27Phototransduction_Homo sapiens_hsa047441.54334099
28Graft-versus-host disease_Homo sapiens_hsa053321.54191748
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51898089
30Base excision repair_Homo sapiens_hsa034101.50227915
31Biosynthesis of amino acids_Homo sapiens_hsa012301.50025729
32Glutamatergic synapse_Homo sapiens_hsa047241.45016314
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42424604
34Butanoate metabolism_Homo sapiens_hsa006501.41448948
35Circadian entrainment_Homo sapiens_hsa047131.40850053
36Serotonergic synapse_Homo sapiens_hsa047261.39907570
37Synaptic vesicle cycle_Homo sapiens_hsa047211.39320286
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36934558
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.36680358
40Sulfur metabolism_Homo sapiens_hsa009201.35402894
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.34029167
42Selenocompound metabolism_Homo sapiens_hsa004501.32537143
43Basal transcription factors_Homo sapiens_hsa030221.31943572
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.29791477
45Primary immunodeficiency_Homo sapiens_hsa053401.28953974
46Insulin secretion_Homo sapiens_hsa049111.27305978
47Non-homologous end-joining_Homo sapiens_hsa034501.26097691
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.25804076
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25335356
50Calcium signaling pathway_Homo sapiens_hsa040201.24664704
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.23453053
52Allograft rejection_Homo sapiens_hsa053301.22969410
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.22717101
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21751224
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20685603
56Renin secretion_Homo sapiens_hsa049241.20342744
57RNA transport_Homo sapiens_hsa030131.19939293
58Hematopoietic cell lineage_Homo sapiens_hsa046401.17731151
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17409301
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.16968016
61Amphetamine addiction_Homo sapiens_hsa050311.16069498
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14975387
63Glycosaminoglycan degradation_Homo sapiens_hsa005311.13238627
64Arginine and proline metabolism_Homo sapiens_hsa003301.12741842
65Salivary secretion_Homo sapiens_hsa049701.11575961
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11150869
67Folate biosynthesis_Homo sapiens_hsa007901.10781547
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10114349
69Fructose and mannose metabolism_Homo sapiens_hsa000511.10007346
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09831426
71Tyrosine metabolism_Homo sapiens_hsa003501.08796582
72Other glycan degradation_Homo sapiens_hsa005111.08648583
73Mineral absorption_Homo sapiens_hsa049781.07501816
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06388643
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06268390
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03790202
77Measles_Homo sapiens_hsa051621.02641827
78DNA replication_Homo sapiens_hsa030301.02437085
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00124112
80GABAergic synapse_Homo sapiens_hsa047270.98620779
81Pyruvate metabolism_Homo sapiens_hsa006200.98411231
82Fatty acid biosynthesis_Homo sapiens_hsa000610.97630119
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97600385
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96938291
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96859508
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93832213
87Carbon metabolism_Homo sapiens_hsa012000.93191023
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92398208
89Arginine biosynthesis_Homo sapiens_hsa002200.91775707
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90918858
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90162677
92Peroxisome_Homo sapiens_hsa041460.90098360
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88097210
94Oxidative phosphorylation_Homo sapiens_hsa001900.87177074
95One carbon pool by folate_Homo sapiens_hsa006700.86329271
96Cholinergic synapse_Homo sapiens_hsa047250.84481812
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84398448
98Huntingtons disease_Homo sapiens_hsa050160.84246382
99cAMP signaling pathway_Homo sapiens_hsa040240.83970148
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83608719
101Ovarian steroidogenesis_Homo sapiens_hsa049130.79581324
102African trypanosomiasis_Homo sapiens_hsa051430.79527274
103Mismatch repair_Homo sapiens_hsa034300.79123399
104Chemical carcinogenesis_Homo sapiens_hsa052040.78117989
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77731823
106Type I diabetes mellitus_Homo sapiens_hsa049400.77679667
107Cocaine addiction_Homo sapiens_hsa050300.77323946
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76657827
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.75901099
110Lysine degradation_Homo sapiens_hsa003100.75850228
111Metabolic pathways_Homo sapiens_hsa011000.75794409
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75770465
113Homologous recombination_Homo sapiens_hsa034400.73166371
114Parkinsons disease_Homo sapiens_hsa050120.71063656
115Retinol metabolism_Homo sapiens_hsa008300.70534507
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70489384
117Chemokine signaling pathway_Homo sapiens_hsa040620.70404653
118beta-Alanine metabolism_Homo sapiens_hsa004100.67321285
119Type II diabetes mellitus_Homo sapiens_hsa049300.67234367
120Tryptophan metabolism_Homo sapiens_hsa003800.66936504
121Phagosome_Homo sapiens_hsa041450.65904292
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.64725675
123Ribosome_Homo sapiens_hsa030100.64605479
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64112562
125Nucleotide excision repair_Homo sapiens_hsa034200.64048139
126Regulation of autophagy_Homo sapiens_hsa041400.63591841
127Steroid biosynthesis_Homo sapiens_hsa001000.62982686
128Cardiac muscle contraction_Homo sapiens_hsa042600.62619815
129Propanoate metabolism_Homo sapiens_hsa006400.61808183
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.61619972
131Pyrimidine metabolism_Homo sapiens_hsa002400.61158570
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60925088
133Axon guidance_Homo sapiens_hsa043600.60561854
134RNA polymerase_Homo sapiens_hsa030200.60052657
135Purine metabolism_Homo sapiens_hsa002300.59421744
136Dopaminergic synapse_Homo sapiens_hsa047280.59392115
137Steroid hormone biosynthesis_Homo sapiens_hsa001400.58855140
138Gap junction_Homo sapiens_hsa045400.58562105
139Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58271545
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57583875
141Gastric acid secretion_Homo sapiens_hsa049710.57020160
142Vibrio cholerae infection_Homo sapiens_hsa051100.56698737
143Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56652471
144Histidine metabolism_Homo sapiens_hsa003400.56170449
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55825888
146Long-term depression_Homo sapiens_hsa047300.55760482
147Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55562821
148mTOR signaling pathway_Homo sapiens_hsa041500.55384345
149Long-term potentiation_Homo sapiens_hsa047200.54849093
150Bile secretion_Homo sapiens_hsa049760.50968010
151Inositol phosphate metabolism_Homo sapiens_hsa005620.50227901
152Oocyte meiosis_Homo sapiens_hsa041140.49159791
153Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48942016
154Ras signaling pathway_Homo sapiens_hsa040140.48011546
155T cell receptor signaling pathway_Homo sapiens_hsa046600.47444276
156Malaria_Homo sapiens_hsa051440.46976425
157AMPK signaling pathway_Homo sapiens_hsa041520.46434149
158Pancreatic secretion_Homo sapiens_hsa049720.44974677
159Hedgehog signaling pathway_Homo sapiens_hsa043400.43556107
160ABC transporters_Homo sapiens_hsa020100.43487005
161Glutathione metabolism_Homo sapiens_hsa004800.43244366
162Wnt signaling pathway_Homo sapiens_hsa043100.42839523
163Osteoclast differentiation_Homo sapiens_hsa043800.42839227
164Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42417802
165Fatty acid elongation_Homo sapiens_hsa000620.41724891
166TNF signaling pathway_Homo sapiens_hsa046680.41220708
167Renin-angiotensin system_Homo sapiens_hsa046140.40576925
168Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40042799
169Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40002705
170Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39348635
171Tuberculosis_Homo sapiens_hsa051520.37892876
172Oxytocin signaling pathway_Homo sapiens_hsa049210.36359808
173Maturity onset diabetes of the young_Homo sapiens_hsa049500.35946572
174Vitamin B6 metabolism_Homo sapiens_hsa007500.34772550
175Leishmaniasis_Homo sapiens_hsa051400.34699270
176Vitamin digestion and absorption_Homo sapiens_hsa049770.31004938

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