DCP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)6.01768829
2nuclear pore complex assembly (GO:0051292)5.79172394
3chromatin remodeling at centromere (GO:0031055)5.65657463
4nuclear pore organization (GO:0006999)5.65207061
5CENP-A containing nucleosome assembly (GO:0034080)5.57166691
6histone exchange (GO:0043486)5.09082288
7mitotic sister chromatid cohesion (GO:0007064)5.02048876
8negative regulation of DNA-dependent DNA replication (GO:2000104)4.85426461
9DNA double-strand break processing (GO:0000729)4.84573238
10mitotic spindle checkpoint (GO:0071174)4.53501719
11negative regulation of mitotic metaphase/anaphase transition (GO:0045841)4.50082292
12negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.50082292
13negative regulation of mitotic sister chromatid segregation (GO:0033048)4.50082292
14negative regulation of mitotic sister chromatid separation (GO:2000816)4.50082292
15negative regulation of sister chromatid segregation (GO:0033046)4.50082292
16negative regulation of chromosome segregation (GO:0051985)4.45421775
17protein localization to kinetochore (GO:0034501)4.43011846
18DNA unwinding involved in DNA replication (GO:0006268)4.39107184
19negative regulation of histone methylation (GO:0031061)4.37165938
20mitotic G2/M transition checkpoint (GO:0044818)4.35661434
21negative regulation of DNA recombination (GO:0045910)4.33736574
22regulation of mitotic sister chromatid separation (GO:0010965)4.27963752
23regulation of sister chromatid segregation (GO:0033045)4.27963752
24pore complex assembly (GO:0046931)4.27138892
25DNA replication checkpoint (GO:0000076)4.26140025
26DNA ligation (GO:0006266)4.25566613
27mitotic chromosome condensation (GO:0007076)4.17918165
28mitotic spindle assembly checkpoint (GO:0007094)4.16860263
29regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.16823792
30spindle assembly checkpoint (GO:0071173)4.11327515
31double-strand break repair via nonhomologous end joining (GO:0006303)4.10881613
32non-recombinational repair (GO:0000726)4.10881613
33sister chromatid segregation (GO:0000819)4.06163457
34regulation of mitotic spindle checkpoint (GO:1903504)4.02184494
35regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.02184494
36regulation of sister chromatid cohesion (GO:0007063)4.00094016
37mitotic nuclear envelope disassembly (GO:0007077)3.98762228
38DNA strand elongation involved in DNA replication (GO:0006271)3.95368478
39synapsis (GO:0007129)3.94282782
40DNA topological change (GO:0006265)3.86827205
41membrane disassembly (GO:0030397)3.85523406
42nuclear envelope disassembly (GO:0051081)3.85523406
43mitotic G2 DNA damage checkpoint (GO:0007095)3.85259824
44replication fork processing (GO:0031297)3.82791868
45regulation of histone H3-K9 methylation (GO:0051570)3.80358928
46DNA strand elongation (GO:0022616)3.78718226
47mitotic sister chromatid segregation (GO:0000070)3.78430163
48mitotic recombination (GO:0006312)3.75537542
49regulation of RNA export from nucleus (GO:0046831)3.69773693
50establishment of integrated proviral latency (GO:0075713)3.64246570
51telomere maintenance via semi-conservative replication (GO:0032201)3.63113554
52regulation of helicase activity (GO:0051095)3.62797598
53protein localization to chromosome, centromeric region (GO:0071459)3.61500902
54mitotic metaphase plate congression (GO:0007080)3.59546055
55DNA geometric change (GO:0032392)3.57172891
56DNA duplex unwinding (GO:0032508)3.56334419
57heterochromatin organization (GO:0070828)3.53972277
58regulation of translational termination (GO:0006449)3.53359017
59negative regulation of mitosis (GO:0045839)3.51704456
60regulation of centriole replication (GO:0046599)3.49773358
61cytoplasmic mRNA processing body assembly (GO:0033962)3.49739421
62NLS-bearing protein import into nucleus (GO:0006607)3.48230648
63DNA replication-dependent nucleosome organization (GO:0034723)3.47658136
64DNA replication-dependent nucleosome assembly (GO:0006335)3.47658136
65regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.47586438
66telomere maintenance via recombination (GO:0000722)3.44177149
67response to X-ray (GO:0010165)3.43690607
68dosage compensation (GO:0007549)3.40158521
69positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.39958534
70positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.39958534
71positive regulation of mitotic sister chromatid separation (GO:1901970)3.39958534
72peptidyl-lysine dimethylation (GO:0018027)3.39486675
73maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.38979207
74centriole replication (GO:0007099)3.38285974
75somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.36527927
76isotype switching (GO:0045190)3.36527927
77somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.36527927
78histone H2A monoubiquitination (GO:0035518)3.34838839
79intra-S DNA damage checkpoint (GO:0031573)3.34428987
80chromatin assembly (GO:0031497)3.32647339
81kinetochore organization (GO:0051383)3.32500431
82regulation of gene silencing by RNA (GO:0060966)3.32263988
83regulation of posttranscriptional gene silencing (GO:0060147)3.32263988
84regulation of gene silencing by miRNA (GO:0060964)3.32263988
85regulation of DNA methylation (GO:0044030)3.31388571
86glucocorticoid receptor signaling pathway (GO:0042921)3.31180814
87DNA catabolic process, exonucleolytic (GO:0000738)3.30437105
88metaphase plate congression (GO:0051310)3.27855509
89negative regulation of DNA repair (GO:0045738)3.25939040
90regulation of nuclear cell cycle DNA replication (GO:0033262)3.24762330
91paraxial mesoderm development (GO:0048339)3.24232833
92RNA stabilization (GO:0043489)3.22683239
93mRNA stabilization (GO:0048255)3.22683239
94resolution of meiotic recombination intermediates (GO:0000712)3.22139058
95positive regulation of chromosome segregation (GO:0051984)3.18694653
96negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.16883651
97negative regulation of translation, ncRNA-mediated (GO:0040033)3.16883651
98regulation of translation, ncRNA-mediated (GO:0045974)3.16883651
99regulation of spindle organization (GO:0090224)3.16518962
100corticosteroid receptor signaling pathway (GO:0031958)3.15566001
101regulation of centrosome cycle (GO:0046605)3.14406863
102regulation of mitotic spindle organization (GO:0060236)3.14245987
103monoubiquitinated protein deubiquitination (GO:0035520)3.13884232
104purine nucleobase biosynthetic process (GO:0009113)3.12727529
105somatic cell DNA recombination (GO:0016444)3.12107890
106somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.12107890
107negative regulation of nuclear division (GO:0051784)3.11489140
108establishment of chromosome localization (GO:0051303)3.03884998
109regulation of nucleobase-containing compound transport (GO:0032239)3.03501453
110chromatin assembly or disassembly (GO:0006333)3.02075452
111protein localization to chromosome (GO:0034502)2.96500228
112negative regulation of histone modification (GO:0031057)2.91795738
113regulation of centrosome duplication (GO:0010824)2.90903027
114meiotic chromosome segregation (GO:0045132)2.90268447
115nuclear envelope organization (GO:0006998)2.87847219
116regulation of DNA endoreduplication (GO:0032875)2.85018955
117DNA conformation change (GO:0071103)2.83688437
118sister chromatid cohesion (GO:0007062)2.81970829
119DNA replication initiation (GO:0006270)2.81393080
120negative regulation of chromatin modification (GO:1903309)2.80616937
121regulation of chromosome segregation (GO:0051983)2.80599904
122chromosome segregation (GO:0007059)2.77804415
123histone H3-K9 methylation (GO:0051567)2.76216103
124folic acid-containing compound biosynthetic process (GO:0009396)2.75376720
125gene silencing by RNA (GO:0031047)2.74559869
126DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.74127132
127spliceosomal tri-snRNP complex assembly (GO:0000244)2.72603981
128regulation of telomere maintenance via telomerase (GO:0032210)2.71222217
129chromosome condensation (GO:0030261)2.68109755
130regulation of translational fidelity (GO:0006450)2.66863403
131negative regulation of histone acetylation (GO:0035067)2.66515306
132kinetochore assembly (GO:0051382)2.65893624
133mRNA transport (GO:0051028)2.64983990
134spindle checkpoint (GO:0031577)2.61945882
135regulation of double-strand break repair (GO:2000779)2.60725173
136positive regulation of SMAD protein import into nucleus (GO:0060391)2.60446055
137regulation of gene silencing (GO:0060968)2.60339511
138ATP-dependent chromatin remodeling (GO:0043044)2.59873494
139regulation of mitotic metaphase/anaphase transition (GO:0030071)2.59323924
140translesion synthesis (GO:0019985)2.54764412
141attachment of spindle microtubules to kinetochore (GO:0008608)2.54044265
142DNA replication-independent nucleosome assembly (GO:0006336)2.53559997
143DNA replication-independent nucleosome organization (GO:0034724)2.53559997
144regulation of mRNA stability (GO:0043488)2.53118682
145regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.52768592
146IMP biosynthetic process (GO:0006188)2.52483661
147regulation of protein polyubiquitination (GO:1902914)2.51884480
148regulation of DNA damage checkpoint (GO:2000001)2.51151491
149peptidyl-arginine methylation (GO:0018216)2.49644931
150peptidyl-arginine N-methylation (GO:0035246)2.49644931
151somatic diversification of immune receptors via somatic mutation (GO:0002566)2.48353260
152somatic hypermutation of immunoglobulin genes (GO:0016446)2.48353260
153regulation of mitotic sister chromatid segregation (GO:0033047)2.46691104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.73901307
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.53818201
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.28675113
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.70009894
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.25399789
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.04842562
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.99870132
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.94591693
9MYC_22102868_ChIP-Seq_BL_Human2.63009255
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.53743847
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.31616171
12SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.26643713
13ELK1_19687146_ChIP-ChIP_HELA_Human2.20994730
14* EST1_17652178_ChIP-ChIP_JURKAT_Human2.17921981
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.15264221
16EWS_26573619_Chip-Seq_HEK293_Human2.13396084
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.09090372
18AR_21909140_ChIP-Seq_LNCAP_Human2.08935389
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.00634498
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.00343514
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00096575
22E2F7_22180533_ChIP-Seq_HELA_Human11.8467412
23* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98939909
24FUS_26573619_Chip-Seq_HEK293_Human1.89504008
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.88043800
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86731413
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86144145
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.81858032
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.79654043
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76791661
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.76274866
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75092316
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.73085658
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.70132940
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67169813
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.65555917
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62431564
38* TAF15_26573619_Chip-Seq_HEK293_Human1.60460632
39VDR_23849224_ChIP-Seq_CD4+_Human1.59952183
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.58146206
41* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56741665
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56126227
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54915865
44* FOXP3_21729870_ChIP-Seq_TREG_Human1.54317797
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.52539129
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.52182691
47ZNF274_21170338_ChIP-Seq_K562_Hela1.51274318
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48151315
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45709296
50* P300_19829295_ChIP-Seq_ESCs_Human1.45129435
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42161048
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40917817
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40622516
54IGF1R_20145208_ChIP-Seq_DFB_Human1.39601475
55TCF3_18692474_ChIP-Seq_MESCs_Mouse1.39377092
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.35244686
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35127292
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35083892
59TCF7_22412390_ChIP-Seq_EML_Mouse1.34967721
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34591163
61NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.34304091
62VDR_22108803_ChIP-Seq_LS180_Human1.33920657
63NANOG_16153702_ChIP-ChIP_HESCs_Human1.33112346
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32244417
65KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32010414
66KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32010414
67KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32010414
68* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.31955356
69* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31023057
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29598552
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29401774
72MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28715089
73PKCTHETA_26484144_Chip-Seq_BREAST_Human1.28114933
74* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26000979
75SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.25783323
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24326321
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22365911
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.22169232
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20504515
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.20267411
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.19362914
82KDM2B_26808549_Chip-Seq_DND41_Human1.19347961
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.19043524
84CIITA_25753668_ChIP-Seq_RAJI_Human1.18969500
85SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.16876604
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16716739
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16560180
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15495120
89IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15214571
90ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12030139
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11865386
92SOX2_16153702_ChIP-ChIP_HESCs_Human1.11298506
93VDR_21846776_ChIP-Seq_THP-1_Human1.10076864
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09369975
95IRF1_19129219_ChIP-ChIP_H3396_Human1.09358218
96PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08600529
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08160882
98CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07563634
99KDM5A_27292631_Chip-Seq_BREAST_Human1.06716356
100KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06610035
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06518248
102ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06460725
103POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.06332929
104MYC_18940864_ChIP-ChIP_HL60_Human1.06105403
105FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.04971154
106NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04558215
107* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04249706
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00927915
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.00731074
110SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99152515
111SMAD_19615063_ChIP-ChIP_OVARY_Human0.98756094
112SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98709041
113EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97601907
114STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.96956142
115TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.96954707
116POU5F1_16518401_ChIP-PET_MESCs_Mouse0.96157159
117EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95602774
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95196647
119* SALL4_22934838_ChIP-ChIP_CD34+_Human0.94970770
120UTX_26944678_Chip-Seq_JUKART_Human0.93594714
121GBX2_23144817_ChIP-Seq_PC3_Human0.93452213
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93414957
123* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93184287
124ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93174268
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92240746
126MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91923372
127ER_23166858_ChIP-Seq_MCF-7_Human0.91513522
128IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90998981
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88539535
130KDM2B_26808549_Chip-Seq_JURKAT_Human0.88227427
131ETS1_20019798_ChIP-Seq_JURKAT_Human0.87813230
132STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87591080
133* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87075668
134IRF8_21731497_ChIP-ChIP_J774_Mouse0.86971413
135ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86297388
136CHD1_26751641_Chip-Seq_LNCaP_Human0.85882472
137CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85076450
138SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84785668
139XRN2_22483619_ChIP-Seq_HELA_Human0.84488507
140RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.84475934
141TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84468820
142POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84468820
143RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84277567
144DCP1A_22483619_ChIP-Seq_HELA_Human0.83143298
145STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.82891381
146E2F1_18555785_ChIP-Seq_MESCs_Mouse0.82870917
147* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82771232
148KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82714294
149NANOG_18555785_Chip-Seq_ESCs_Mouse0.82249065
150SMAD3_21741376_ChIP-Seq_EPCs_Human0.80920294
151MAF_26560356_Chip-Seq_TH1_Human0.80869156
152GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80179417
153DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80084011
154WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.79796723
155MYB_26560356_Chip-Seq_TH1_Human0.79415527
156CRX_20693478_ChIP-Seq_RETINA_Mouse0.79389821
157PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78746273
158NANOG_18692474_ChIP-Seq_MESCs_Mouse0.78401276
159SOX2_18692474_ChIP-Seq_MESCs_Mouse0.78244506
160MYB_26560356_Chip-Seq_TH2_Human0.77491030
161E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76760190
162TBX3_20139965_ChIP-Seq_ESCs_Mouse0.76587581
163POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.76156968
164NANOG_16518401_ChIP-PET_MESCs_Mouse0.75215761

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.57290264
2MP0003123_paternal_imprinting3.40386081
3MP0003111_abnormal_nucleus_morphology3.39689645
4MP0008057_abnormal_DNA_replication3.13235259
5MP0003077_abnormal_cell_cycle3.09624921
6MP0010352_gastrointestinal_tract_polyps3.03973187
7MP0005076_abnormal_cell_differentiation2.99624740
8MP0003693_abnormal_embryo_hatching2.94027937
9MP0000569_abnormal_digit_pigmentation2.93901889
10MP0010307_abnormal_tumor_latency2.88709579
11MP0003705_abnormal_hypodermis_morpholog2.72149772
12MP0004957_abnormal_blastocyst_morpholog2.71413756
13MP0003121_genomic_imprinting2.70067752
14MP0003718_maternal_effect2.65666809
15MP0010234_abnormal_vibrissa_follicle2.25845499
16MP0000350_abnormal_cell_proliferation2.25463445
17MP0003890_abnormal_embryonic-extraembry2.14935317
18MP0001730_embryonic_growth_arrest2.10854903
19MP0006292_abnormal_olfactory_placode2.04734545
20MP0002084_abnormal_developmental_patter2.04247520
21MP0009697_abnormal_copulation1.99130358
22MP0005380_embryogenesis_phenotype1.98905171
23MP0001672_abnormal_embryogenesis/_devel1.98905171
24MP0003787_abnormal_imprinting1.98890318
25MP0002086_abnormal_extraembryonic_tissu1.90270351
26MP0002085_abnormal_embryonic_tissue1.87202881
27MP0004197_abnormal_fetal_growth/weight/1.79276036
28MP0003984_embryonic_growth_retardation1.78981735
29MP0008877_abnormal_DNA_methylation1.78753638
30MP0001697_abnormal_embryo_size1.78310248
31MP0002088_abnormal_embryonic_growth/wei1.77884728
32MP0004808_abnormal_hematopoietic_stem1.77126868
33MP0001293_anophthalmia1.68644019
34MP0008007_abnormal_cellular_replicative1.66288537
35MP0008058_abnormal_DNA_repair1.56930629
36MP0003786_premature_aging1.55351462
37MP0002396_abnormal_hematopoietic_system1.53669853
38MP0002102_abnormal_ear_morphology1.51709932
39MP0000537_abnormal_urethra_morphology1.48668955
40MP0003122_maternal_imprinting1.47228421
41MP0002080_prenatal_lethality1.42497549
42MP0009053_abnormal_anal_canal1.41893520
43MP0008932_abnormal_embryonic_tissue1.37242133
44MP0001188_hyperpigmentation1.35076766
45MP0002009_preneoplasia1.34582850
46MP0005075_abnormal_melanosome_morpholog1.33176801
47MP0003937_abnormal_limbs/digits/tail_de1.32723985
48MP0001929_abnormal_gametogenesis1.31466392
49MP0003303_peritoneal_inflammation1.30465421
50MP0009703_decreased_birth_body1.27448158
51MP0010030_abnormal_orbit_morphology1.26123122
52MP0003941_abnormal_skin_development1.25236322
53MP0000733_abnormal_muscle_development1.22332274
54MP0001915_intracranial_hemorrhage1.20729603
55MP0003567_abnormal_fetal_cardiomyocyte1.18007840
56MP0009278_abnormal_bone_marrow1.17887803
57MP0002006_tumorigenesis1.17783076
58MP0001177_atelectasis1.17575107
59MP0000428_abnormal_craniofacial_morphol1.17435602
60MP0006054_spinal_hemorrhage1.16801254
61MP0003935_abnormal_craniofacial_develop1.16768287
62MP0000372_irregular_coat_pigmentation1.15737775
63MP0003221_abnormal_cardiomyocyte_apopto1.11885439
64MP0003566_abnormal_cell_adhesion1.11214254
65MP0002254_reproductive_system_inflammat1.11027830
66MP0003385_abnormal_body_wall1.08917325
67MP0005187_abnormal_penis_morphology1.08171956
68MP0009672_abnormal_birth_weight1.08120604
69MP0002925_abnormal_cardiovascular_devel1.06821251
70MP0006035_abnormal_mitochondrial_morpho1.06727760
71MP0000490_abnormal_crypts_of1.06681824
72MP0000313_abnormal_cell_death1.04314252
73MP0003861_abnormal_nervous_system1.02735538
74MP0003119_abnormal_digestive_system1.00639781
75MP0005395_other_phenotype1.00544305
76MP0005248_abnormal_Harderian_gland1.00478581
77MP0000432_abnormal_head_morphology0.99477405
78MP0008789_abnormal_olfactory_epithelium0.99299908
79MP0000703_abnormal_thymus_morphology0.99170791
80MP0000653_abnormal_sex_gland0.98870658
81MP0002751_abnormal_autonomic_nervous0.98827628
82MP0002019_abnormal_tumor_incidence0.98400604
83MP0001145_abnormal_male_reproductive0.97403452
84MP0005623_abnormal_meninges_morphology0.92998970
85MP0002877_abnormal_melanocyte_morpholog0.92694960
86MP0000647_abnormal_sebaceous_gland0.92267623
87MP0002398_abnormal_bone_marrow0.91717993
88MP0005397_hematopoietic_system_phenotyp0.88882354
89MP0001545_abnormal_hematopoietic_system0.88882354
90MP0004264_abnormal_extraembryonic_tissu0.88761960
91MP0001849_ear_inflammation0.88705123
92MP0002092_abnormal_eye_morphology0.88333301
93MP0002653_abnormal_ependyma_morphology0.87985365
94MP0002938_white_spotting0.87910901
95MP0005499_abnormal_olfactory_system0.85014692
96MP0005394_taste/olfaction_phenotype0.85014692
97MP0000516_abnormal_urinary_system0.84783866
98MP0005367_renal/urinary_system_phenotyp0.84783866
99MP0003091_abnormal_cell_migration0.83864043
100MP0008770_decreased_survivor_rate0.83718299
101MP0004233_abnormal_muscle_weight0.83359927
102MP0003115_abnormal_respiratory_system0.81986027
103MP0005621_abnormal_cell_physiology0.80965488
104MP0003448_altered_tumor_morphology0.80856514
105MP0006072_abnormal_retinal_apoptosis0.79225731
106MP0003755_abnormal_palate_morphology0.79187699
107MP0000427_abnormal_hair_cycle0.79020530
108MP0003300_gastrointestinal_ulcer0.78605581
109MP0003136_yellow_coat_color0.78169080
110MP0004185_abnormal_adipocyte_glucose0.77852317
111MP0002111_abnormal_tail_morphology0.76580873
112MP0002210_abnormal_sex_determination0.74939082
113MP0003943_abnormal_hepatobiliary_system0.73704308
114MP0002166_altered_tumor_susceptibility0.72485256
115MP0005384_cellular_phenotype0.72298376
116MP0003656_abnormal_erythrocyte_physiolo0.72000730
117MP0010678_abnormal_skin_adnexa0.71265574
118MP0002075_abnormal_coat/hair_pigmentati0.71125404
119MP0002697_abnormal_eye_size0.70933030
120MP0002932_abnormal_joint_morphology0.70858610
121MP0000358_abnormal_cell_content/0.70806880
122MP0005174_abnormal_tail_pigmentation0.70493934
123MP0001286_abnormal_eye_development0.69710640
124MP0001119_abnormal_female_reproductive0.69678312
125MP0003195_calcinosis0.68526349
126MP0003698_abnormal_male_reproductive0.68463213
127MP0003699_abnormal_female_reproductive0.68267324
128MP0004859_abnormal_synaptic_plasticity0.68037631
129MP0001324_abnormal_eye_pigmentation0.67867779
130MP0002090_abnormal_vision0.67042875
131MP0000266_abnormal_heart_morphology0.66347755
132MP0002722_abnormal_immune_system0.65753010
133MP0002233_abnormal_nose_morphology0.65575943
134MP0005253_abnormal_eye_physiology0.65463754
135MP0005167_abnormal_blood-brain_barrier0.64994764
136MP0000371_diluted_coat_color0.64840662
137MP0002114_abnormal_axial_skeleton0.63831297
138MP0005391_vision/eye_phenotype0.63248331
139MP0000689_abnormal_spleen_morphology0.60861663
140MP0005647_abnormal_sex_gland0.60699348
141MP0005408_hypopigmentation0.59821896
142MP0004147_increased_porphyrin_level0.54474058
143MP0001485_abnormal_pinna_reflex0.53573590

Predicted human phenotypes

RankGene SetZ-score
1Nephroblastoma (Wilms tumor) (HP:0002667)4.01527056
2Embryonal renal neoplasm (HP:0011794)3.82639043
3Abnormal lung lobation (HP:0002101)3.78311345
4Ependymoma (HP:0002888)3.32424879
5Abnormality of the preputium (HP:0100587)3.27337679
6Short 4th metacarpal (HP:0010044)3.23111334
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.23111334
8Birth length less than 3rd percentile (HP:0003561)3.01331318
9Abnormality of the astrocytes (HP:0100707)2.95158197
10Astrocytoma (HP:0009592)2.95158197
11Volvulus (HP:0002580)2.94799077
12Medulloblastoma (HP:0002885)2.92773870
13Abnormality of the duodenum (HP:0002246)2.89042871
14Hyperacusis (HP:0010780)2.86651662
15Chromsome breakage (HP:0040012)2.72276510
16Increased nuchal translucency (HP:0010880)2.71850515
17Renal duplication (HP:0000075)2.69480147
18Abnormality of the labia minora (HP:0012880)2.66658291
19Pancreatic islet-cell hyperplasia (HP:0004510)2.62114706
20Sloping forehead (HP:0000340)2.58074141
21Absent radius (HP:0003974)2.55666400
22Clubbing of toes (HP:0100760)2.53820339
23Rhabdomyosarcoma (HP:0002859)2.53382339
24Supernumerary spleens (HP:0009799)2.53145494
25Agnosia (HP:0010524)2.50961065
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.50836963
27Gonadotropin excess (HP:0000837)2.47865163
28Abnormality of the fingertips (HP:0001211)2.46980564
29Neoplasm of the oral cavity (HP:0100649)2.46742340
30Colon cancer (HP:0003003)2.43491826
31Neoplasm of the adrenal cortex (HP:0100641)2.42652509
32Papillary thyroid carcinoma (HP:0002895)2.38652017
33Intestinal atresia (HP:0011100)2.38170322
34Bifid tongue (HP:0010297)2.37883238
35Abnormality of the 4th metacarpal (HP:0010012)2.37176127
36Embryonal neoplasm (HP:0002898)2.36740103
37Glioma (HP:0009733)2.36538872
38Neoplasm of the colon (HP:0100273)2.36190608
39Aplasia involving forearm bones (HP:0009822)2.35570581
40Absent forearm bone (HP:0003953)2.35570581
41Renovascular hypertension (HP:0100817)2.33460148
42Ovarian neoplasm (HP:0100615)2.32182533
43Sandal gap (HP:0001852)2.32002879
44Long eyelashes (HP:0000527)2.30665411
45Breast carcinoma (HP:0003002)2.30069574
46Ectopic kidney (HP:0000086)2.29234819
47Gastrointestinal carcinoma (HP:0002672)2.27365324
48Malignant gastrointestinal tract tumors (HP:0006749)2.27365324
49Heterotopia (HP:0002282)2.26632836
50Clitoromegaly (HP:0000057)2.25259973
51Neoplasm of the adrenal gland (HP:0100631)2.24196278
52Multiple enchondromatosis (HP:0005701)2.24074002
53Combined immunodeficiency (HP:0005387)2.20479716
54Neoplasm of striated muscle (HP:0009728)2.19782543
55Oligodactyly (hands) (HP:0001180)2.19260872
56Abnormality of chromosome stability (HP:0003220)2.19120116
57Prominent nose (HP:0000448)2.17239553
58Skull defect (HP:0001362)2.17167978
59Subacute progressive viral hepatitis (HP:0006572)2.15997270
60Pointed chin (HP:0000307)2.14907358
61Elfin facies (HP:0004428)2.13915681
62Facial hemangioma (HP:0000329)2.13871153
63Broad thumb (HP:0011304)2.11613198
64B lymphocytopenia (HP:0010976)2.10655011
65Triphalangeal thumb (HP:0001199)2.10650760
66Septo-optic dysplasia (HP:0100842)2.10375856
67Thyroid carcinoma (HP:0002890)2.10271190
68Carpal bone hypoplasia (HP:0001498)2.09912062
69Abnormal hair whorl (HP:0010721)2.09442734
70Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.08579691
71Stenosis of the external auditory canal (HP:0000402)2.07527860
72Trigonocephaly (HP:0000243)2.07333165
73Abnormality of the carotid arteries (HP:0005344)2.05810700
74Deviation of the thumb (HP:0009603)2.05566868
75Neoplasm of the small intestine (HP:0100833)2.02595809
76Urethral obstruction (HP:0000796)2.00862152
77Biliary tract neoplasm (HP:0100574)2.00362597
78Aqueductal stenosis (HP:0002410)1.99463552
79Cafe-au-lait spot (HP:0000957)1.98839746
80Proximal placement of thumb (HP:0009623)1.98614327
81Obsessive-compulsive behavior (HP:0000722)1.97091839
82Abnormality of B cell number (HP:0010975)1.96715694
83Amaurosis fugax (HP:0100576)1.96279945
84Abnormality of the septum pellucidum (HP:0007375)1.96277564
85Abnormality of the diencephalon (HP:0010662)1.94940344
86Absent frontal sinuses (HP:0002688)1.94280834
87Abnormality of chromosome segregation (HP:0002916)1.92814669
88IgM deficiency (HP:0002850)1.92568603
89Overriding aorta (HP:0002623)1.92086994
90Macroorchidism (HP:0000053)1.90584497
91Leiomyosarcoma (HP:0100243)1.89767493
92Uterine leiomyosarcoma (HP:0002891)1.89767493
93Transitional cell carcinoma of the bladder (HP:0006740)1.89747744
94Selective tooth agenesis (HP:0001592)1.89480604
95Patellar aplasia (HP:0006443)1.88766124
96T lymphocytopenia (HP:0005403)1.88145599
97Abnormality of aspartate family amino acid metabolism (HP:0010899)1.88062790
98Abnormality of the clitoris (HP:0000056)1.88048427
99Horseshoe kidney (HP:0000085)1.87771025
100Meckel diverticulum (HP:0002245)1.87211299
101Cutis marmorata (HP:0000965)1.86642012
102Aplasia/Hypoplasia of the uvula (HP:0010293)1.86576735
103Basal cell carcinoma (HP:0002671)1.86041764
104High pitched voice (HP:0001620)1.85458677
105Shawl scrotum (HP:0000049)1.85289563
106Spastic diplegia (HP:0001264)1.84741614
107Disinhibition (HP:0000734)1.83542557
108Pseudobulbar signs (HP:0002200)1.83258003
109Abnormality of methionine metabolism (HP:0010901)1.83125982
110Thyroiditis (HP:0100646)1.82829635
111Abnormality of the lower motor neuron (HP:0002366)1.82568378
112Inappropriate behavior (HP:0000719)1.79711415
113Acute myeloid leukemia (HP:0004808)1.78892240
114Broad palm (HP:0001169)1.78865747
115Rib fusion (HP:0000902)1.78219163
116Bladder carcinoma (HP:0002862)1.77253781
117Bladder neoplasm (HP:0009725)1.77253781
118Sacral dimple (HP:0000960)1.77088860
119Supernumerary ribs (HP:0005815)1.76933529
120Aplasia/Hypoplasia of the patella (HP:0006498)1.75682408
121Abnormal number of incisors (HP:0011064)1.75414528
122Truncal obesity (HP:0001956)1.75036388
123Abnormality of the ileum (HP:0001549)1.74498723
124Cupped ear (HP:0000378)1.73810807
125Choanal atresia (HP:0000453)1.73663787
126Myelodysplasia (HP:0002863)1.73644849
127Ankyloglossia (HP:0010296)1.73639976
128Midline defect of the nose (HP:0004122)1.73614470
129Hepatoblastoma (HP:0002884)1.73339728
130Bowel diverticulosis (HP:0005222)1.72973003
131Arteriovenous malformation (HP:0100026)1.72634218
132Cortical dysplasia (HP:0002539)1.72231734
133Narrow palate (HP:0000189)1.71280910
134Aplasia/Hypoplasia of the sternum (HP:0006714)1.71241680
135Cystic hygroma (HP:0000476)1.70749454
136Long clavicles (HP:0000890)1.70660023
137Atresia of the external auditory canal (HP:0000413)1.70004030
138Broad phalanges of the hand (HP:0009768)1.69373916
139Flat cornea (HP:0007720)1.68722666
140Small hand (HP:0200055)1.68105029
141Hematochezia (HP:0002573)1.68068081
142Deep philtrum (HP:0002002)1.67975546
143Blepharitis (HP:0000498)1.67736345
144Absent septum pellucidum (HP:0001331)1.66285463
145Rectal prolapse (HP:0002035)1.66176562
146Progressive inability to walk (HP:0002505)1.65441120
147Cellular immunodeficiency (HP:0005374)1.65400278
148Abnormality of serum amino acid levels (HP:0003112)1.64697289
149Shallow orbits (HP:0000586)1.62768295
150Severe combined immunodeficiency (HP:0004430)1.61553855
151Dyschromatopsia (HP:0007641)1.61529258
152Uterine neoplasm (HP:0010784)1.61372266
153Abnormal auditory evoked potentials (HP:0006958)1.61089734
154Broad finger (HP:0001500)1.60002055
155Large earlobe (HP:0009748)1.59873318
156Fibrous tissue neoplasm (HP:0012316)1.59369122
157Small intestinal stenosis (HP:0012848)1.56632233
158Duodenal stenosis (HP:0100867)1.56632233
159Hypopigmentation of the fundus (HP:0007894)1.56517449

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.34905277
2CDK124.17613604
3BUB14.04652762
4LATS13.45196976
5EEF2K3.10839160
6NEK22.93432178
7TRIM282.88084417
8ZAK2.74156132
9TNIK2.60739122
10EIF2AK32.59567182
11LATS22.51075552
12WNK32.32374909
13NUAK12.16854571
14BMPR1B2.11548641
15PKN22.06677334
16MAP3K102.06527181
17TAF12.05582301
18SCYL22.05535564
19TTK1.99559859
20ALK1.95700749
21STK31.90426656
22MST41.90417346
23SIK21.90146910
24EIF2AK11.76687976
25MAP3K91.75281649
26RPS6KB21.64607510
27NEK11.61768939
28KSR21.60745825
29PBK1.54963173
30SRPK11.53820559
31WEE11.52631525
32BRD41.51737883
33PLK21.48130213
34CDK41.46784542
35CHEK21.45430049
36ATR1.43965815
37CHEK11.35791381
38ERBB31.32494102
39CDK61.28206577
40NLK1.28163871
41FRK1.23577953
42RIPK11.20129053
43KSR11.19635758
44VRK11.19082716
45YES11.17827085
46PLK11.16757365
47STK41.14996190
48EIF2AK21.14574842
49PLK31.14260208
50MAP3K81.11981319
51PDGFRA1.11191774
52ATM1.10851133
53CAMK1D1.09402176
54MELK1.05899527
55FGFR31.03924110
56STK38L1.01645950
57PAK41.01385225
58CDK71.00538587
59STK380.98100870
60TYRO30.96512619
61AURKB0.94600190
62CDK20.94558653
63PLK40.93479490
64BCR0.92964965
65MTOR0.92701828
66STK100.85229724
67CSNK1D0.84684982
68MKNK10.84162603
69RPS6KA40.84070469
70CAMK1G0.83556847
71TRIB30.83384114
72CLK10.77390236
73TSSK60.75680331
74FGFR10.75245094
75CDK90.74588502
76TEC0.72749037
77MAP3K130.72098723
78RAF10.71932844
79ACVR1B0.70482137
80CDK10.70121167
81MAP3K40.69300392
82PDGFRB0.69160295
83PRKD30.68903796
84PAK60.68608244
85TAOK10.68379817
86PTK60.67698636
87RET0.65998040
88MAP3K50.64918624
89MAP3K60.63993364
90PIM10.63933742
91CSNK1G10.63793912
92TGFBR10.63686661
93BMX0.62978867
94PASK0.62611825
95FGFR20.62246297
96TLK10.62176214
97SGK30.62013604
98DYRK30.61888321
99OXSR10.60306137
100STK240.60105679
101EPHA20.59500593
102TYK20.59291112
103PNCK0.58451065
104JAK30.58242806
105NEK60.53819116
106JAK10.53115055
107DDR20.52936318
108MARK30.52661047
109MAPK140.52044942
110PRKDC0.51961888
111MAPK100.51693367
112CCNB10.51550024
113SIK30.50465111
114BRSK20.49757565
115MKNK20.49613005
116ERBB40.48736223
117TTN0.48681845
118RIPK40.48384945
119CSNK1E0.47315914
120FGR0.47277855
121WNK10.47111141
122BRAF0.41822482
123NEK90.41554182
124STK160.41510969
125GSK3B0.41069083
126AKT10.40100922
127VRK20.38203061
128DMPK0.37501479
129NTRK30.37361251
130MAPK130.37227252
131HCK0.35640077
132MATK0.35478454
133BRSK10.34860363
134RPS6KB10.34284144
135EGFR0.34167506
136CSNK1G20.31163347
137CDK30.30909516
138CSNK2A10.28517210
139MAP4K20.27226177
140FLT30.25839916
141PDK20.25832333
142STK390.25237647
143CSNK2A20.24432815
144CDK190.20082294
145BMPR20.20039193
146CASK0.19955934
147DYRK1A0.19599835
148CSNK1G30.18252690

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030222.52863887
2Cell cycle_Homo sapiens_hsa041102.32593751
3DNA replication_Homo sapiens_hsa030302.30571027
4Proteasome_Homo sapiens_hsa030502.27116555
5Mismatch repair_Homo sapiens_hsa034302.24961712
6RNA transport_Homo sapiens_hsa030132.00873613
7Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.98620522
8Propanoate metabolism_Homo sapiens_hsa006401.87167030
9mRNA surveillance pathway_Homo sapiens_hsa030151.77777889
10Steroid biosynthesis_Homo sapiens_hsa001001.70098694
11Cysteine and methionine metabolism_Homo sapiens_hsa002701.68315659
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68227790
13MicroRNAs in cancer_Homo sapiens_hsa052061.55794476
14Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.54339230
15Protein export_Homo sapiens_hsa030601.53540859
16One carbon pool by folate_Homo sapiens_hsa006701.52705990
17Spliceosome_Homo sapiens_hsa030401.51181318
18RNA polymerase_Homo sapiens_hsa030201.49554084
19mTOR signaling pathway_Homo sapiens_hsa041501.47702389
20Fanconi anemia pathway_Homo sapiens_hsa034601.46947210
21Chronic myeloid leukemia_Homo sapiens_hsa052201.45008261
22Oocyte meiosis_Homo sapiens_hsa041141.41829725
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.40401270
24Systemic lupus erythematosus_Homo sapiens_hsa053221.38765675
25Colorectal cancer_Homo sapiens_hsa052101.37907282
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36519456
27Selenocompound metabolism_Homo sapiens_hsa004501.30213462
28Homologous recombination_Homo sapiens_hsa034401.28174715
29Viral carcinogenesis_Homo sapiens_hsa052031.25808006
30Herpes simplex infection_Homo sapiens_hsa051681.24646956
31p53 signaling pathway_Homo sapiens_hsa041151.22856806
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20597470
33Adherens junction_Homo sapiens_hsa045201.19257994
34Non-small cell lung cancer_Homo sapiens_hsa052231.15040028
35Base excision repair_Homo sapiens_hsa034101.14736237
36HTLV-I infection_Homo sapiens_hsa051661.13208327
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11968842
38Endometrial cancer_Homo sapiens_hsa052131.11941751
39Hippo signaling pathway_Homo sapiens_hsa043901.11345617
40Glioma_Homo sapiens_hsa052141.11296238
41Pancreatic cancer_Homo sapiens_hsa052121.10517935
42Small cell lung cancer_Homo sapiens_hsa052221.08946249
43Dorso-ventral axis formation_Homo sapiens_hsa043201.08771312
44Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07967770
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06069540
46Nucleotide excision repair_Homo sapiens_hsa034201.05398999
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.04683629
48TGF-beta signaling pathway_Homo sapiens_hsa043501.03610396
49Hepatitis B_Homo sapiens_hsa051611.01385964
50* RNA degradation_Homo sapiens_hsa030180.99359410
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98594688
52Non-homologous end-joining_Homo sapiens_hsa034500.98064794
53Notch signaling pathway_Homo sapiens_hsa043300.97859820
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95651660
55Proteoglycans in cancer_Homo sapiens_hsa052050.95120394
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94951482
57Influenza A_Homo sapiens_hsa051640.94885458
58Viral myocarditis_Homo sapiens_hsa054160.94606136
59Lysine degradation_Homo sapiens_hsa003100.94142887
60B cell receptor signaling pathway_Homo sapiens_hsa046620.93887441
61Vitamin B6 metabolism_Homo sapiens_hsa007500.92826560
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92649494
63Basal cell carcinoma_Homo sapiens_hsa052170.92206247
64Purine metabolism_Homo sapiens_hsa002300.91685798
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.91101326
66Pyrimidine metabolism_Homo sapiens_hsa002400.88621119
67Thyroid cancer_Homo sapiens_hsa052160.88376032
68Type II diabetes mellitus_Homo sapiens_hsa049300.87877547
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87568507
70Measles_Homo sapiens_hsa051620.86353880
71Alcoholism_Homo sapiens_hsa050340.86287796
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85555568
73Prolactin signaling pathway_Homo sapiens_hsa049170.84771378
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84732144
75Antigen processing and presentation_Homo sapiens_hsa046120.84716022
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84358720
77Long-term potentiation_Homo sapiens_hsa047200.83278933
78Leishmaniasis_Homo sapiens_hsa051400.82814145
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.81045178
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80384469
81Estrogen signaling pathway_Homo sapiens_hsa049150.79433645
82Renal cell carcinoma_Homo sapiens_hsa052110.78402709
83TNF signaling pathway_Homo sapiens_hsa046680.78270643
84ErbB signaling pathway_Homo sapiens_hsa040120.77951503
85Epstein-Barr virus infection_Homo sapiens_hsa051690.77554890
86FoxO signaling pathway_Homo sapiens_hsa040680.76433826
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75846220
88Wnt signaling pathway_Homo sapiens_hsa043100.75125313
89Prostate cancer_Homo sapiens_hsa052150.73578911
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73404696
91VEGF signaling pathway_Homo sapiens_hsa043700.72578764
92HIF-1 signaling pathway_Homo sapiens_hsa040660.72467285
93Apoptosis_Homo sapiens_hsa042100.71657075
94Toxoplasmosis_Homo sapiens_hsa051450.71368135
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70987259
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70973056
97Osteoclast differentiation_Homo sapiens_hsa043800.70743386
98Pyruvate metabolism_Homo sapiens_hsa006200.70208305
99T cell receptor signaling pathway_Homo sapiens_hsa046600.70015967
100Pathways in cancer_Homo sapiens_hsa052000.69796769
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68176400
102Acute myeloid leukemia_Homo sapiens_hsa052210.67640525
103Hedgehog signaling pathway_Homo sapiens_hsa043400.67605373
104Chemokine signaling pathway_Homo sapiens_hsa040620.65782481
105Platelet activation_Homo sapiens_hsa046110.64885043
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64680551
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63546683
108Shigellosis_Homo sapiens_hsa051310.62636153
109Melanoma_Homo sapiens_hsa052180.61870498
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61662596
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59885391
112MAPK signaling pathway_Homo sapiens_hsa040100.59636214
113Salmonella infection_Homo sapiens_hsa051320.58852458
114GnRH signaling pathway_Homo sapiens_hsa049120.58677935
115Tuberculosis_Homo sapiens_hsa051520.56581047
116Focal adhesion_Homo sapiens_hsa045100.56401915
117Rap1 signaling pathway_Homo sapiens_hsa040150.56250847
118Choline metabolism in cancer_Homo sapiens_hsa052310.55487671
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.55000425
120Legionellosis_Homo sapiens_hsa051340.54498549
121Type I diabetes mellitus_Homo sapiens_hsa049400.53220329
122Fatty acid elongation_Homo sapiens_hsa000620.52632916
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45348351
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42776474
125Carbon metabolism_Homo sapiens_hsa012000.39318777
126Biosynthesis of amino acids_Homo sapiens_hsa012300.38616337
127Primary immunodeficiency_Homo sapiens_hsa053400.36183550
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34163912
129Olfactory transduction_Homo sapiens_hsa047400.26859124
130Tight junction_Homo sapiens_hsa045300.26740189
131Regulation of autophagy_Homo sapiens_hsa041400.24459258
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24221189
133Inositol phosphate metabolism_Homo sapiens_hsa005620.23835980
134Vitamin digestion and absorption_Homo sapiens_hsa049770.23263344
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21369810
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19911909
137Fatty acid metabolism_Homo sapiens_hsa012120.19174574
138Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.19013645
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16264637
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15513583
141Phototransduction_Homo sapiens_hsa047440.15012017
142Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.12395448
143Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.12384300
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12221090
145Glutathione metabolism_Homo sapiens_hsa004800.10134219
146Metabolic pathways_Homo sapiens_hsa011000.09893668
147Taste transduction_Homo sapiens_hsa047420.05812721
148Peroxisome_Homo sapiens_hsa041460.04727946
149Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.03687640

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