DCP1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)6.60723988
2mitotic chromosome condensation (GO:0007076)5.79266829
3protein localization to kinetochore (GO:0034501)5.77403144
4protein localization to chromosome, centromeric region (GO:0071459)5.03102391
5mitotic metaphase plate congression (GO:0007080)4.96693032
6regulation of sister chromatid cohesion (GO:0007063)4.72867298
7female gamete generation (GO:0007292)4.57879851
8attachment of spindle microtubules to kinetochore (GO:0008608)4.56176733
9piRNA metabolic process (GO:0034587)4.48418549
10negative regulation of histone methylation (GO:0031061)4.47948457
11histone H2A monoubiquitination (GO:0035518)4.44828625
12metaphase plate congression (GO:0051310)4.36944125
13mitotic nuclear envelope disassembly (GO:0007077)4.31746721
14DNA deamination (GO:0045006)4.30138159
15mitotic sister chromatid segregation (GO:0000070)4.10941311
16regulation of centriole replication (GO:0046599)4.10531754
17protein localization to chromosome (GO:0034502)4.09903856
18behavioral response to nicotine (GO:0035095)4.08758470
19membrane disassembly (GO:0030397)4.06774881
20nuclear envelope disassembly (GO:0051081)4.06774881
21establishment of chromosome localization (GO:0051303)4.03109298
22regulation of spindle organization (GO:0090224)4.01745429
23regulation of mitotic spindle organization (GO:0060236)4.00700277
24meiotic cell cycle (GO:0051321)3.99792426
25mitotic sister chromatid cohesion (GO:0007064)3.96790903
26nuclear pore complex assembly (GO:0051292)3.91850404
27positive regulation of chromosome segregation (GO:0051984)3.89216630
28RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.85744778
29regulation of DNA methylation (GO:0044030)3.83536030
30sister chromatid segregation (GO:0000819)3.80010160
31histone H2A ubiquitination (GO:0033522)3.74881685
32negative regulation of meiosis (GO:0045835)3.68323291
33negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.68145174
34negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.66584055
35regulation of meiosis (GO:0040020)3.65870887
36positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.63169812
37positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.62056182
38positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.62056182
39positive regulation of mitotic sister chromatid separation (GO:1901970)3.62056182
40regulation of histone H3-K27 methylation (GO:0061085)3.60439784
41regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.59492427
42nuclear pore organization (GO:0006999)3.59449858
43regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.56208290
44meiotic chromosome segregation (GO:0045132)3.55511065
45chromosome segregation (GO:0007059)3.55006257
46folic acid-containing compound biosynthetic process (GO:0009396)3.54785987
47pre-miRNA processing (GO:0031054)3.52759267
48DNA methylation (GO:0006306)3.51989862
49DNA alkylation (GO:0006305)3.51989862
50indole-containing compound catabolic process (GO:0042436)3.50799067
51indolalkylamine catabolic process (GO:0046218)3.50799067
52tryptophan catabolic process (GO:0006569)3.50799067
53protein K6-linked ubiquitination (GO:0085020)3.46421008
54chromatin assembly or disassembly (GO:0006333)3.45531543
55regulation of hypersensitivity (GO:0002883)3.44731824
56kinetochore organization (GO:0051383)3.44395780
57regulation of acrosome reaction (GO:0060046)3.42784146
58gene silencing by RNA (GO:0031047)3.41937635
59water-soluble vitamin biosynthetic process (GO:0042364)3.40899173
60DNA replication-independent nucleosome organization (GO:0034724)3.40303359
61DNA replication-independent nucleosome assembly (GO:0006336)3.40303359
62establishment of spindle localization (GO:0051293)3.40070124
63regulation of chromosome segregation (GO:0051983)3.34080561
64mitochondrial respiratory chain complex I assembly (GO:0032981)3.34027754
65NADH dehydrogenase complex assembly (GO:0010257)3.34027754
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.34027754
67CENP-A containing nucleosome assembly (GO:0034080)3.33833099
68spindle checkpoint (GO:0031577)3.33651812
69negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.30621903
70negative regulation of DNA-templated transcription, elongation (GO:0032785)3.30621903
71DNA double-strand break processing (GO:0000729)3.30611070
72nuclear envelope organization (GO:0006998)3.30262156
73regulation of exit from mitosis (GO:0007096)3.27371573
74fucose catabolic process (GO:0019317)3.26261286
75L-fucose metabolic process (GO:0042354)3.26261286
76L-fucose catabolic process (GO:0042355)3.26261286
77chromatin remodeling at centromere (GO:0031055)3.24548215
78adaptation of signaling pathway (GO:0023058)3.21851671
79preassembly of GPI anchor in ER membrane (GO:0016254)3.21102376
80regulation of histone H3-K9 methylation (GO:0051570)3.19673462
81regulation of centrosome cycle (GO:0046605)3.19479969
82positive regulation of humoral immune response (GO:0002922)3.16422933
83negative regulation of systemic arterial blood pressure (GO:0003085)3.15459071
84negative regulation of chromosome segregation (GO:0051985)3.15300319
85rRNA catabolic process (GO:0016075)3.14238473
86indolalkylamine metabolic process (GO:0006586)3.14195740
87DNA methylation involved in gamete generation (GO:0043046)3.09819604
88mitotic spindle checkpoint (GO:0071174)3.09509159
89protein polyglutamylation (GO:0018095)3.09447602
90neural tube formation (GO:0001841)3.09411371
91regulation of mitotic metaphase/anaphase transition (GO:0030071)3.09250504
92negative regulation of meiotic cell cycle (GO:0051447)3.09174368
93histone exchange (GO:0043486)3.09058234
94DNA replication checkpoint (GO:0000076)3.08815394
95negative regulation of mitotic sister chromatid separation (GO:2000816)3.07319480
96negative regulation of mitotic sister chromatid segregation (GO:0033048)3.07319480
97negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.07319480
98negative regulation of sister chromatid segregation (GO:0033046)3.07319480
99DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.07111009
100protein complex biogenesis (GO:0070271)3.06364822
101mitotic spindle assembly checkpoint (GO:0007094)3.05860557
102positive regulation of cAMP-mediated signaling (GO:0043950)3.05510104
103spindle assembly checkpoint (GO:0071173)3.04599541
104epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.03795473
105epithelial cilium movement (GO:0003351)3.01998591
106negative regulation of transcription regulatory region DNA binding (GO:2000678)3.01744960
107DNA damage induced protein phosphorylation (GO:0006975)2.99379645
108immunoglobulin mediated immune response (GO:0016064)2.99039994
109* nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98986266
110multicellular organism reproduction (GO:0032504)2.98249028
111regulation of sister chromatid segregation (GO:0033045)2.97611624
112regulation of mitotic sister chromatid separation (GO:0010965)2.97611624
113regulation of mitotic sister chromatid segregation (GO:0033047)2.97611624
114cytoplasmic mRNA processing body assembly (GO:0033962)2.96238805
115kinetochore assembly (GO:0051382)2.94588133
116establishment of spindle orientation (GO:0051294)2.92522133
117oocyte development (GO:0048599)2.91664225
118oocyte maturation (GO:0001556)2.90431971
119regulation of retinoic acid receptor signaling pathway (GO:0048385)2.88027403
120chromosome condensation (GO:0030261)2.87990000
121DNA replication-dependent nucleosome organization (GO:0034723)2.87974831
122DNA replication-dependent nucleosome assembly (GO:0006335)2.87974831
123DNA damage response, signal transduction resulting in transcription (GO:0042772)2.86869248
124tryptophan metabolic process (GO:0006568)2.86616281
125positive regulation of defense response to virus by host (GO:0002230)2.86273749
126chromatin assembly (GO:0031497)2.85250210
127notochord development (GO:0030903)2.84640713
128regulation of transforming growth factor beta2 production (GO:0032909)2.84176798
129mitochondrial respiratory chain complex assembly (GO:0033108)2.83761013
130interkinetic nuclear migration (GO:0022027)2.82949211
131regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.82383005
132replication fork processing (GO:0031297)2.82308071
133regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.81936704
134negative regulation of cytosolic calcium ion concentration (GO:0051481)2.81109853
135sulfation (GO:0051923)2.79073401
136GPI anchor metabolic process (GO:0006505)2.67986549
137* exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66526305
138regulation of immunoglobulin secretion (GO:0051023)2.65361714
139cilium morphogenesis (GO:0060271)2.63617529
140L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.62829887
141pyrimidine dimer repair (GO:0006290)2.59302054
142negative regulation of cAMP-mediated signaling (GO:0043951)2.59136174
143protein K11-linked deubiquitination (GO:0035871)2.55589631
144kynurenine metabolic process (GO:0070189)2.53664998
145regulation of cytokine production involved in inflammatory response (GO:1900015)2.53134137
146respiratory chain complex IV assembly (GO:0008535)2.51832072
147retinal cone cell development (GO:0046549)2.51529357
148dentate gyrus development (GO:0021542)2.50963093
149ncRNA catabolic process (GO:0034661)2.50708387
150regulation of chronic inflammatory response (GO:0002676)2.48050206
151somite development (GO:0061053)2.47765350
152response to UV-C (GO:0010225)2.46928038
153negative regulation of telomere maintenance (GO:0032205)2.45610665
154recombinational repair (GO:0000725)2.45169440
155amine catabolic process (GO:0009310)2.44860045
156cellular biogenic amine catabolic process (GO:0042402)2.44860045
157positive regulation of granulocyte differentiation (GO:0030854)2.43940034
158photoreceptor cell development (GO:0042461)2.43600168
159behavioral response to ethanol (GO:0048149)2.42879246
160regulation of DNA endoreduplication (GO:0032875)2.42725689
161double-strand break repair via homologous recombination (GO:0000724)2.42275281
162regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.42172815
163activated T cell proliferation (GO:0050798)2.42135856
164regulation of memory T cell differentiation (GO:0043380)2.40701900
165male meiosis (GO:0007140)2.37733867
166resolution of meiotic recombination intermediates (GO:0000712)2.37094454
167establishment of protein localization to Golgi (GO:0072600)2.36568645
168centriole replication (GO:0007099)2.36438665
169negative regulation of DNA binding (GO:0043392)2.33946619
170protein localization to cilium (GO:0061512)2.33161812
171sperm motility (GO:0030317)2.32273964
172response to pheromone (GO:0019236)2.30853752
173photoreceptor cell maintenance (GO:0045494)2.30443420
174C-terminal protein lipidation (GO:0006501)2.29151918
175positive regulation of organelle assembly (GO:1902117)2.27864887
176regulation of interleukin-12 biosynthetic process (GO:0045075)2.27624032
177negative regulation of mast cell activation (GO:0033004)2.26984587
178synapsis (GO:0007129)2.26386108
179protein targeting to Golgi (GO:0000042)2.25856658
180DNA integration (GO:0015074)2.25843901
181mannosylation (GO:0097502)2.25253733
182regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.25193720
183regulation of cilium movement (GO:0003352)2.24467591
184detection of light stimulus involved in visual perception (GO:0050908)2.24413010
185detection of light stimulus involved in sensory perception (GO:0050962)2.24413010
186regulation of female receptivity (GO:0045924)2.23902241
187DNA demethylation (GO:0080111)2.22987271
188regulation of meiosis I (GO:0060631)2.20389670
189endoderm formation (GO:0001706)2.19416176
190RNA phosphodiester bond hydrolysis (GO:0090501)2.18751307
191platelet dense granule organization (GO:0060155)2.18471341

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human7.02980736
2* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.18010225
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.99059685
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.57707588
5ZNF274_21170338_ChIP-Seq_K562_Hela3.51909180
6AR_21909140_ChIP-Seq_LNCAP_Human3.39149285
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.36020600
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.31036381
9IGF1R_20145208_ChIP-Seq_DFB_Human3.05378955
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.92719313
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92499852
12GBX2_23144817_ChIP-Seq_PC3_Human2.86896541
13VDR_22108803_ChIP-Seq_LS180_Human2.84384232
14MYC_22102868_ChIP-Seq_BL_Human2.82661096
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.79044423
16EZH2_22144423_ChIP-Seq_EOC_Human2.78612698
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.65719173
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.59559026
19* GABP_17652178_ChIP-ChIP_JURKAT_Human2.41248892
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32915855
21EWS_26573619_Chip-Seq_HEK293_Human2.31042954
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30403833
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.25744741
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.20688016
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16670315
26TAF15_26573619_Chip-Seq_HEK293_Human2.14393969
27FUS_26573619_Chip-Seq_HEK293_Human2.14051248
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12503799
29* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11879104
30TP63_19390658_ChIP-ChIP_HaCaT_Human2.10099486
31IRF1_19129219_ChIP-ChIP_H3396_Human2.08377042
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00008133
33E2F7_22180533_ChIP-Seq_HELA_Human10.2735111
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.97989900
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.93172285
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90963199
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90292978
38P300_19829295_ChIP-Seq_ESCs_Human1.86780909
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82250690
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.81077646
41ELK1_19687146_ChIP-ChIP_HELA_Human1.78368208
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.78080243
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77944134
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.74765164
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.72379042
46CBP_20019798_ChIP-Seq_JUKART_Human1.72264778
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.72264778
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.71856694
49CIITA_25753668_ChIP-Seq_RAJI_Human1.68974759
50ER_23166858_ChIP-Seq_MCF-7_Human1.67274725
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63966551
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63173569
53* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63070059
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57576546
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.57563059
56NANOG_21062744_ChIP-ChIP_HESCs_Human1.56737901
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55996541
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55996541
59* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48727289
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45829647
61TCF7_22412390_ChIP-Seq_EML_Mouse1.45678694
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44112418
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44017876
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43519793
65SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39867585
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38710583
67STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38531897
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38296873
69SMAD4_21799915_ChIP-Seq_A2780_Human1.38035332
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.33278344
71E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.31609704
72CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31415673
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31299936
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30234248
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29976424
76TP53_22573176_ChIP-Seq_HFKS_Human1.29324794
77KDM5A_27292631_Chip-Seq_BREAST_Human1.28676649
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28293235
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28181914
80* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27343667
81AR_25329375_ChIP-Seq_VCAP_Human1.26930922
82STAT3_23295773_ChIP-Seq_U87_Human1.25618902
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25304261
84MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23656077
85VDR_21846776_ChIP-Seq_THP-1_Human1.23424701
86NANOG_19829295_ChIP-Seq_ESCs_Human1.22691688
87SOX2_19829295_ChIP-Seq_ESCs_Human1.22691688
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.22687704
89TCF4_23295773_ChIP-Seq_U87_Human1.22606717
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22136269
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.21487568
92GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21261298
93* ETS1_20019798_ChIP-Seq_JURKAT_Human1.20438082
94* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19580500
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18578620
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17755218
97UTX_26944678_Chip-Seq_JUKART_Human1.16665453
98IRF8_22096565_ChIP-ChIP_GC-B_Human1.16316366
99MYC_18940864_ChIP-ChIP_HL60_Human1.15397100
100* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14320086
101* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14042182
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.14004753
103NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.13829137
104BCAT_22108803_ChIP-Seq_LS180_Human1.13387193
105KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13027607
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10987996
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10867755
108* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09901313
109IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08560964
110GATA3_26560356_Chip-Seq_TH2_Human1.08522866
111FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08134396
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07696219
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07473449
114GATA1_26923725_Chip-Seq_HPCs_Mouse1.07158210
115SMAD_19615063_ChIP-ChIP_OVARY_Human1.06779016
116FLI1_21867929_ChIP-Seq_TH2_Mouse1.06316779
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04909986
118HTT_18923047_ChIP-ChIP_STHdh_Human1.04018387
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03558757
120MYB_26560356_Chip-Seq_TH2_Human1.03531698
121AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03307576
122RUNX2_22187159_ChIP-Seq_PCA_Human1.03190096
123ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02672557
124SMAD3_21741376_ChIP-Seq_EPCs_Human1.02494025
125NANOG_18555785_Chip-Seq_ESCs_Mouse1.02333685
126TCF4_22108803_ChIP-Seq_LS180_Human1.02330071
127* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02061029
128KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01930902
129* CDX2_22108803_ChIP-Seq_LS180_Human1.01660885
130BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01619428
131SMAD4_21741376_ChIP-Seq_EPCs_Human1.01472130
132OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01380735
133CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01298862
134CRX_20693478_ChIP-Seq_RETINA_Mouse1.00938186
135CBX2_27304074_Chip-Seq_ESCs_Mouse1.00934611
136RNF2_27304074_Chip-Seq_NSC_Mouse1.00755344
137POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00347952
138CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00304593
139PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00073813
140FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99129613
141PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99030431
142MYB_26560356_Chip-Seq_TH1_Human0.98374843
143NCOR_22424771_ChIP-Seq_293T_Human0.97604514
144IRF8_21731497_ChIP-ChIP_J774_Mouse0.96594436
145* GABP_19822575_ChIP-Seq_HepG2_Human0.96130106
146TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95866076
147TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95513614
148CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95310241
149FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95277007
150GATA3_21878914_ChIP-Seq_MCF-7_Human0.94800020
151* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93721634
152ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93508314
153PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93494194
154FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93479531
155TFEB_21752829_ChIP-Seq_HELA_Human0.93052269
156RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91531060
157* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90578430
158CHD1_26751641_Chip-Seq_LNCaP_Human0.88017416
159SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.87693690
160KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86456612
161DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85274325
162MAF_26560356_Chip-Seq_TH1_Human0.84901572
163YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83792342
164XRN2_22483619_ChIP-Seq_HELA_Human0.83611810
165ATF3_27146783_Chip-Seq_COLON_Human0.83492695
166HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83227914
167FOXP3_21729870_ChIP-Seq_TREG_Human0.83216846
168* VDR_23849224_ChIP-Seq_CD4+_Human0.83185359
169PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82448034
170* GATA3_27048872_Chip-Seq_THYMUS_Human0.81989102
171TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.81638257
172MYC_18358816_ChIP-ChIP_MESCs_Mouse0.81623354
173RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81513727
174MYB_21317192_ChIP-Seq_ERMYB_Mouse0.80333890
175FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.79360725
176KDM2B_26808549_Chip-Seq_JURKAT_Human0.78681322
177KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.78361070
178* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.78153386
179* POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.77866137
180* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77249587
181POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.76590819
182TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76529710
183RUNX_20019798_ChIP-Seq_JUKART_Human0.75657897
184CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.75280220
185FOXO3_23340844_ChIP-Seq_DLD1_Human0.75171342
186TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75120947
187RUNX1_26923725_Chip-Seq_HPCs_Mouse0.74831216
188SPI1_23547873_ChIP-Seq_NB4_Human0.74068331
189IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.73771563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.25138286
2MP0003718_maternal_effect4.00777765
3MP0003111_abnormal_nucleus_morphology3.79137504
4MP0003693_abnormal_embryo_hatching3.71536688
5MP0003077_abnormal_cell_cycle3.57136276
6MP0002138_abnormal_hepatobiliary_system3.51839504
7MP0004957_abnormal_blastocyst_morpholog3.08222931
8MP0008877_abnormal_DNA_methylation2.88702343
9MP0003195_calcinosis2.60918076
10MP0000372_irregular_coat_pigmentation2.47399306
11MP0005646_abnormal_pituitary_gland2.42897357
12MP0000569_abnormal_digit_pigmentation2.38968452
13MP0002876_abnormal_thyroid_physiology2.35540897
14MP0008057_abnormal_DNA_replication2.30082957
15MP0002653_abnormal_ependyma_morphology2.22823658
16MP0000350_abnormal_cell_proliferation2.15782255
17MP0003950_abnormal_plasma_membrane2.15535434
18MP0005451_abnormal_body_composition2.14350221
19MP0008007_abnormal_cellular_replicative2.14138932
20MP0003121_genomic_imprinting2.09513019
21MP0001119_abnormal_female_reproductive2.06348980
22MP0002837_dystrophic_cardiac_calcinosis2.05923126
23MP0001730_embryonic_growth_arrest2.04972479
24MP0005551_abnormal_eye_electrophysiolog1.98247008
25MP0003699_abnormal_female_reproductive1.93437834
26MP0004264_abnormal_extraembryonic_tissu1.90683370
27MP0002396_abnormal_hematopoietic_system1.88070374
28MP0010352_gastrointestinal_tract_polyps1.84146982
29MP0005395_other_phenotype1.81186025
30MP0008789_abnormal_olfactory_epithelium1.76816730
31MP0002163_abnormal_gland_morphology1.74806021
32MP0001529_abnormal_vocalization1.73196212
33MP0002160_abnormal_reproductive_system1.73092688
34MP0005076_abnormal_cell_differentiation1.72983382
35MP0008058_abnormal_DNA_repair1.71475017
36MP0008932_abnormal_embryonic_tissue1.71292540
37MP0005253_abnormal_eye_physiology1.71020155
38MP0003123_paternal_imprinting1.70259138
39MP0001672_abnormal_embryogenesis/_devel1.69762440
40MP0005380_embryogenesis_phenotype1.69762440
41MP0003763_abnormal_thymus_physiology1.68938823
42MP0001697_abnormal_embryo_size1.65328291
43MP0002085_abnormal_embryonic_tissue1.65284360
44MP0001929_abnormal_gametogenesis1.65147650
45MP0002084_abnormal_developmental_patter1.64372049
46MP0005671_abnormal_response_to1.62503959
47MP0001915_intracranial_hemorrhage1.61020439
48MP0000653_abnormal_sex_gland1.57422518
49MP0005394_taste/olfaction_phenotype1.54353937
50MP0005499_abnormal_olfactory_system1.54353937
51MP0003705_abnormal_hypodermis_morpholog1.52713325
52MP0000631_abnormal_neuroendocrine_gland1.51564207
53MP0001968_abnormal_touch/_nociception1.50857374
54MP0010307_abnormal_tumor_latency1.50696004
55MP0003787_abnormal_imprinting1.50420549
56MP0002210_abnormal_sex_determination1.44461658
57MP0002019_abnormal_tumor_incidence1.42006501
58MP0003984_embryonic_growth_retardation1.40016549
59MP0003724_increased_susceptibility_to1.39198787
60MP0005410_abnormal_fertilization1.37310671
61MP0002088_abnormal_embryonic_growth/wei1.37051999
62MP0004808_abnormal_hematopoietic_stem1.36340760
63MP0002148_abnormal_hypersensitivity_rea1.34062970
64MP0002086_abnormal_extraembryonic_tissu1.33594804
65MP0005023_abnormal_wound_healing1.33554439
66MP0006072_abnormal_retinal_apoptosis1.31514984
67MP0003937_abnormal_limbs/digits/tail_de1.30129313
68MP0001501_abnormal_sleep_pattern1.28167834
69MP0000733_abnormal_muscle_development1.28144478
70MP0009785_altered_susceptibility_to1.27318384
71MP0002877_abnormal_melanocyte_morpholog1.26099698
72MP0004142_abnormal_muscle_tone1.25001733
73MP0002080_prenatal_lethality1.24813170
74MP0002638_abnormal_pupillary_reflex1.23215686
75MP0000490_abnormal_crypts_of1.21704539
76MP0002277_abnormal_respiratory_mucosa1.19911104
77MP0008995_early_reproductive_senescence1.19544105
78MP0003136_yellow_coat_color1.18798304
79MP0003646_muscle_fatigue1.18772513
80MP0001986_abnormal_taste_sensitivity1.18014880
81MP0001764_abnormal_homeostasis1.17794975
82MP0000313_abnormal_cell_death1.16861226
83MP0005084_abnormal_gallbladder_morpholo1.16274572
84MP0001188_hyperpigmentation1.15491561
85MP0008872_abnormal_physiological_respon1.14746980
86MP0002398_abnormal_bone_marrow1.13709704
87MP0000703_abnormal_thymus_morphology1.13311430
88MP0001849_ear_inflammation1.13198122
89MP0001984_abnormal_olfaction1.12213203
90MP0001790_abnormal_immune_system1.10251369
91MP0005387_immune_system_phenotype1.10251369
92MP0002932_abnormal_joint_morphology1.09691423
93MP0009046_muscle_twitch1.08506018
94MP0001485_abnormal_pinna_reflex1.08202079
95MP0000465_gastrointestinal_hemorrhage1.06996295
96MP0002272_abnormal_nervous_system1.06472740
97MP0005621_abnormal_cell_physiology1.05609116
98MP0003880_abnormal_central_pattern1.02043973
99MP0002161_abnormal_fertility/fecundity1.02005156
100MP0000049_abnormal_middle_ear1.02000449
101MP0001145_abnormal_male_reproductive1.00695620
102MP0001919_abnormal_reproductive_system0.99090194
103MP0003890_abnormal_embryonic-extraembry0.98421846
104MP0005075_abnormal_melanosome_morpholog0.97974332
105MP0004885_abnormal_endolymph0.97322739
106MP0000685_abnormal_immune_system0.96910033
107MP0009745_abnormal_behavioral_response0.96732506
108MP0005174_abnormal_tail_pigmentation0.95480386
109MP0003698_abnormal_male_reproductive0.95386647
110MP0006276_abnormal_autonomic_nervous0.94825401
111MP0009764_decreased_sensitivity_to0.94817779
112MP0002095_abnormal_skin_pigmentation0.94343931
113MP0003566_abnormal_cell_adhesion0.94286130
114MP0010234_abnormal_vibrissa_follicle0.92976488
115MP0004197_abnormal_fetal_growth/weight/0.92114218
116MP0005379_endocrine/exocrine_gland_phen0.89633998
117MP0002102_abnormal_ear_morphology0.89630732
118MP0002928_abnormal_bile_duct0.88472123
119MP0005384_cellular_phenotype0.87699467
120MP0002127_abnormal_cardiovascular_syste0.87581930
121MP0003806_abnormal_nucleotide_metabolis0.87202299
122MP0004510_myositis0.86589022
123MP0002751_abnormal_autonomic_nervous0.86554384
124MP0003453_abnormal_keratinocyte_physiol0.86489289
125MP0000689_abnormal_spleen_morphology0.84281682
126MP0002132_abnormal_respiratory_system0.83820153
127MP0001800_abnormal_humoral_immune0.83465514
128MP0002722_abnormal_immune_system0.82967742
129MP0004924_abnormal_behavior0.82236505
130MP0005386_behavior/neurological_phenoty0.82236505
131MP0004215_abnormal_myocardial_fiber0.82106656
132MP0002938_white_spotting0.81978736
133MP0006035_abnormal_mitochondrial_morpho0.80729074
134MP0002925_abnormal_cardiovascular_devel0.79817423
135MP0010030_abnormal_orbit_morphology0.79244548
136MP0005647_abnormal_sex_gland0.79196399
137MP0005187_abnormal_penis_morphology0.77934579
138MP0005195_abnormal_posterior_eye0.77842797
139MP0000579_abnormal_nail_morphology0.77643903
140MP0009278_abnormal_bone_marrow0.77562029
141MP0000716_abnormal_immune_system0.76720807
142MP0004185_abnormal_adipocyte_glucose0.76363653
143MP0003091_abnormal_cell_migration0.76354302
144MP0002429_abnormal_blood_cell0.76327317
145MP0001486_abnormal_startle_reflex0.74412096
146MP0005310_abnormal_salivary_gland0.74140443
147MP0009333_abnormal_splenocyte_physiolog0.73971624
148MP0001835_abnormal_antigen_presentation0.73927939
149MP0004134_abnormal_chest_morphology0.72556254
150MP0006036_abnormal_mitochondrial_physio0.72393218
151MP0008775_abnormal_heart_ventricle0.72357801
152MP0005266_abnormal_metabolism0.72313385
153MP0009765_abnormal_xenobiotic_induced0.71304646
154MP0005389_reproductive_system_phenotype0.70768759
155MP0005391_vision/eye_phenotype0.70571410
156MP0001293_anophthalmia0.70390992
157MP0003935_abnormal_craniofacial_develop0.70150926
158MP0002736_abnormal_nociception_after0.70049619
159MP0001324_abnormal_eye_pigmentation0.69240909
160MP0002693_abnormal_pancreas_physiology0.68359368
161MP0009697_abnormal_copulation0.68315936
162MP0002557_abnormal_social/conspecific_i0.68261814
163MP0005397_hematopoietic_system_phenotyp0.68088381
164MP0001545_abnormal_hematopoietic_system0.68088381
165MP0006292_abnormal_olfactory_placode0.67845002
166MP0002723_abnormal_immune_serum0.67401405
167MP0000432_abnormal_head_morphology0.66512003
168MP0000477_abnormal_intestine_morphology0.65688967
169MP0003315_abnormal_perineum_morphology0.65580046
170MP0005408_hypopigmentation0.65040006
171MP0003567_abnormal_fetal_cardiomyocyte0.63724213
172MP0002933_joint_inflammation0.63634801
173MP0002452_abnormal_antigen_presenting0.63097720
174MP0003943_abnormal_hepatobiliary_system0.61505998
175MP0003755_abnormal_palate_morphology0.61078068

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.08559136
2Abnormality of the fingertips (HP:0001211)4.02661385
3Male infertility (HP:0003251)3.99590078
4Chromsome breakage (HP:0040012)3.76841031
5Birth length less than 3rd percentile (HP:0003561)3.65989089
6Rhabdomyosarcoma (HP:0002859)3.54392709
7Abnormality of the labia minora (HP:0012880)3.47009448
8Pancreatic fibrosis (HP:0100732)3.44903671
9Molar tooth sign on MRI (HP:0002419)3.41274298
10Abnormality of midbrain morphology (HP:0002418)3.41274298
11True hermaphroditism (HP:0010459)3.39194402
12Premature ovarian failure (HP:0008209)3.32006754
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.20862577
14Cortical dysplasia (HP:0002539)3.08977821
15Patellar aplasia (HP:0006443)3.03461231
16Thyroid-stimulating hormone excess (HP:0002925)3.00953070
17Supernumerary spleens (HP:0009799)2.95686865
18Acute myeloid leukemia (HP:0004808)2.92632180
19Aplasia/Hypoplasia of the sternum (HP:0006714)2.90442996
20Neoplasm of striated muscle (HP:0009728)2.87202798
21Abolished electroretinogram (ERG) (HP:0000550)2.82706147
22Short 1st metacarpal (HP:0010034)2.81979679
23Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.81979679
24Aplasia/Hypoplasia of the patella (HP:0006498)2.77512517
25Medulloblastoma (HP:0002885)2.75998430
26Breast hypoplasia (HP:0003187)2.73972234
27Chronic hepatic failure (HP:0100626)2.72502093
28Methylmalonic acidemia (HP:0002912)2.69735074
29Sandal gap (HP:0001852)2.69241108
30Ectopic kidney (HP:0000086)2.65655060
31Combined immunodeficiency (HP:0005387)2.65173546
32Nephronophthisis (HP:0000090)2.65019088
33Abnormality of chromosome segregation (HP:0002916)2.64263612
34Papillary thyroid carcinoma (HP:0002895)2.62817162
35Short 4th metacarpal (HP:0010044)2.61976548
36Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.61976548
37Shawl scrotum (HP:0000049)2.61394174
38Medial flaring of the eyebrow (HP:0010747)2.61254050
39Neoplasm of the oral cavity (HP:0100649)2.58290854
40Abnormality of the proximal phalanges of the hand (HP:0009834)2.56991408
41Type II lissencephaly (HP:0007260)2.49971648
42Abnormal rod and cone electroretinograms (HP:0008323)2.47916071
43Facial hemangioma (HP:0000329)2.47792158
44Congenital stationary night blindness (HP:0007642)2.45663645
45Hypothermia (HP:0002045)2.43903929
463-Methylglutaconic aciduria (HP:0003535)2.42369243
47Abnormality of chromosome stability (HP:0003220)2.41589445
48Pendular nystagmus (HP:0012043)2.41007200
49Volvulus (HP:0002580)2.40628167
50Bile duct proliferation (HP:0001408)2.39691359
51Abnormal biliary tract physiology (HP:0012439)2.39691359
52Attenuation of retinal blood vessels (HP:0007843)2.36393956
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35881220
54Abnormality of the 1st metacarpal (HP:0010009)2.35823700
55Gastrointestinal carcinoma (HP:0002672)2.35121440
56Malignant gastrointestinal tract tumors (HP:0006749)2.35121440
57Spondylolisthesis (HP:0003302)2.35003248
58Increased nuchal translucency (HP:0010880)2.34330998
59Aplasia/hypoplasia of the uterus (HP:0008684)2.34213015
60Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.33278998
61Methylmalonic aciduria (HP:0012120)2.32935043
62Myelodysplasia (HP:0002863)2.31221887
63Ependymoma (HP:0002888)2.29525224
64Abnormality of the phalanges of the hallux (HP:0010057)2.29368909
65Leiomyosarcoma (HP:0100243)2.28514304
66Uterine leiomyosarcoma (HP:0002891)2.28514304
67Short phalanx of the thumb (HP:0009660)2.28084107
68Abnormality of the renal cortex (HP:0011035)2.28017051
69Abnormality of the renal medulla (HP:0100957)2.27320604
70Long eyelashes (HP:0000527)2.23691036
71Impulsivity (HP:0100710)2.21652718
72Tubular atrophy (HP:0000092)2.20811538
73Trigonocephaly (HP:0000243)2.20507348
74Thyroiditis (HP:0100646)2.18140682
75Lipid accumulation in hepatocytes (HP:0006561)2.17384960
76Prominent nose (HP:0000448)2.17288512
77Sloping forehead (HP:0000340)2.16412632
78Intestinal atresia (HP:0011100)2.15283627
79Cystic liver disease (HP:0006706)2.13022702
80Nephrogenic diabetes insipidus (HP:0009806)2.13014144
81Secondary amenorrhea (HP:0000869)2.09862463
82Transitional cell carcinoma of the bladder (HP:0006740)2.08637301
83Aplastic anemia (HP:0001915)2.08113979
84Stomatitis (HP:0010280)2.07211905
85Male pseudohermaphroditism (HP:0000037)2.06983268
86Broad-based gait (HP:0002136)2.06555407
87Congenital primary aphakia (HP:0007707)2.06479709
88Aplasia/Hypoplasia of the tibia (HP:0005772)2.05990096
89Selective tooth agenesis (HP:0001592)2.05670973
90Pulmonary fibrosis (HP:0002206)2.04025736
91Hypoplasia of the uterus (HP:0000013)2.03824664
92Small intestinal stenosis (HP:0012848)2.03596953
93Duodenal stenosis (HP:0100867)2.03596953
94Abnormality of the intervertebral disk (HP:0005108)2.02423507
95Aplasia/Hypoplasia of the uvula (HP:0010293)2.01034383
96Increased CSF lactate (HP:0002490)2.00940617
97Gait imbalance (HP:0002141)2.00915634
98Progressive inability to walk (HP:0002505)2.00736317
99Abnormality of the ileum (HP:0001549)2.00382465
100Inability to walk (HP:0002540)1.99595423
101Cafe-au-lait spot (HP:0000957)1.99412285
102Abnormality of B cell number (HP:0010975)1.98772314
103Carpal bone hypoplasia (HP:0001498)1.98662458
104Large for gestational age (HP:0001520)1.98383885
105Anencephaly (HP:0002323)1.97492204
106Abnormality of the renal collecting system (HP:0004742)1.97254605
107Hypoproteinemia (HP:0003075)1.97232685
108Short tibia (HP:0005736)1.96335948
109Median cleft lip (HP:0000161)1.96294519
110Shallow orbits (HP:0000586)1.96098371
111Optic nerve hypoplasia (HP:0000609)1.96036359
112Mitochondrial inheritance (HP:0001427)1.95646030
113Agnosia (HP:0010524)1.95375059
114Short thumb (HP:0009778)1.94862270
115Renal cortical cysts (HP:0000803)1.94547828
116Aplasia/Hypoplasia of the tongue (HP:0010295)1.92886661
117Abnormality of the distal phalanx of the thumb (HP:0009617)1.92496355
118Flat capital femoral epiphysis (HP:0003370)1.92419185
119Sparse lateral eyebrow (HP:0005338)1.90304535
120Absent radius (HP:0003974)1.90177089
121Overlapping toe (HP:0001845)1.90174098
122Abnormality of DNA repair (HP:0003254)1.89859799
123Gaze-evoked nystagmus (HP:0000640)1.89774096
124Deviation of the thumb (HP:0009603)1.89461936
125Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89164971
126Acute necrotizing encephalopathy (HP:0006965)1.88381998
127Abnormality of the 4th metacarpal (HP:0010012)1.87561837
128Bladder neoplasm (HP:0009725)1.87380384
129Bladder carcinoma (HP:0002862)1.87380384
130Cerebellar dysplasia (HP:0007033)1.87229305
131Bony spicule pigmentary retinopathy (HP:0007737)1.87196681
132Hyperglycinemia (HP:0002154)1.87046120
133Hypoplastic pelvis (HP:0008839)1.86339284
134IgG deficiency (HP:0004315)1.86071114
135Furrowed tongue (HP:0000221)1.85632352
136Deep venous thrombosis (HP:0002625)1.85315449
137Small hand (HP:0200055)1.85178803
138Colon cancer (HP:0003003)1.84774828
139Increased hepatocellular lipid droplets (HP:0006565)1.84600250
140B lymphocytopenia (HP:0010976)1.84230642
141Rib fusion (HP:0000902)1.84146271
142Deep philtrum (HP:0002002)1.84011345
143Severe combined immunodeficiency (HP:0004430)1.83176335
144High pitched voice (HP:0001620)1.82143815
145Abnormal drinking behavior (HP:0030082)1.80705852
146Polydipsia (HP:0001959)1.80705852
147Hypoplastic labia majora (HP:0000059)1.80195358
148Progressive macrocephaly (HP:0004481)1.79869785
149Postaxial foot polydactyly (HP:0001830)1.79023987
150Hyperventilation (HP:0002883)1.78533123
151Absent forearm bone (HP:0003953)1.77495495
152Aplasia involving forearm bones (HP:0009822)1.77495495
153Severe visual impairment (HP:0001141)1.76767690
154Arterial tortuosity (HP:0005116)1.76534489
155Sclerocornea (HP:0000647)1.75947951
156Aplasia/Hypoplasia of the spleen (HP:0010451)1.75837350
157Infertility (HP:0000789)1.74903102
158Lissencephaly (HP:0001339)1.74445347
159Absent speech (HP:0001344)1.74365875
160Abnormality of macular pigmentation (HP:0008002)1.73928342
161Lip pit (HP:0100267)1.73813721
162Absent thumb (HP:0009777)1.73786807
163Meckel diverticulum (HP:0002245)1.72338807
164Abnormal lung lobation (HP:0002101)1.72162190
165Heterotopia (HP:0002282)1.70951708
166Limited elbow extension (HP:0001377)1.70788067
167Fair hair (HP:0002286)1.70573663
168Proximal placement of thumb (HP:0009623)1.70284328
169Decreased central vision (HP:0007663)1.70150328
170Abnormality of the labia majora (HP:0012881)1.70102780
171Genital tract atresia (HP:0001827)1.69633172
172Anhidrosis (HP:0000970)1.69518961
173Abnormality of the columella (HP:0009929)1.68940651
174Congenital hepatic fibrosis (HP:0002612)1.67852029
175Basal cell carcinoma (HP:0002671)1.67655003
176Abnormality of the astrocytes (HP:0100707)1.66573964
177Astrocytoma (HP:0009592)1.66573964
178Widely spaced teeth (HP:0000687)1.66516113
179Ankle contracture (HP:0006466)1.66256778
180Hypergonadotropic hypogonadism (HP:0000815)1.66111656
181Narrow palate (HP:0000189)1.65828923
182Nephroblastoma (Wilms tumor) (HP:0002667)1.65825723
183Recurrent viral infections (HP:0004429)1.65813690
184Wrist flexion contracture (HP:0001239)1.65403803
185Broad thumb (HP:0011304)1.65359018
186Congenital sensorineural hearing impairment (HP:0008527)1.64981540
187Dandy-Walker malformation (HP:0001305)1.64653947
188Abnormality of the anterior horn cell (HP:0006802)1.64355457
189Vaginal atresia (HP:0000148)1.64341749
190Postaxial hand polydactyly (HP:0001162)1.62677460
191Asplenia (HP:0001746)1.62563329
192Clumsiness (HP:0002312)1.61876862
193Eosinophilia (HP:0001880)1.61350638

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.28056073
2PINK13.87733227
3TTK3.80795314
4EEF2K3.76312352
5TAOK33.69512806
6ADRBK23.69371403
7MOS3.52880845
8CDC73.51727234
9BMPR23.35166750
10STK103.25605087
11LATS13.10216996
12EIF2AK33.06886998
13PLK43.01583918
14CDK122.98191640
15MAP3K62.85031428
16TXK2.60726677
17BMPR1B2.54251442
18WNK32.45583238
19NEK22.24564068
20ZAK2.01825451
21MELK1.91311000
22MAP4K21.89855527
23MAPKAPK31.84833282
24TLK11.84435413
25LATS21.82608506
26TAOK11.78254703
27MARK31.74708559
28CSNK1G31.73226934
29CHEK21.72487549
30GRK11.67231717
31TRIM281.64606568
32MAP3K81.61472281
33CDK91.58118721
34STK31.57087105
35BRAF1.56403299
36BUB11.52077411
37RPS6KB21.51209086
38MST41.51024888
39PLK11.50110589
40KSR21.48718599
41CSNK1G21.40755143
42MAP3K131.40076542
43MAP3K101.39478820
44MKNK21.38145268
45BCKDK1.35507607
46RPS6KA41.32971979
47MAP3K41.31300768
48INSRR1.29910088
49MAPK131.28950888
50CDK81.26436241
51STK161.24729725
52CDK41.18992229
53RAF11.17264545
54MAP3K91.16338468
55MKNK11.16255143
56TNIK1.14075466
57AURKB1.13021404
58MAP2K71.10990173
59ERBB41.06824450
60LRRK21.04899366
61CHEK11.04417946
62MAP4K11.02923774
63STK38L1.02566848
64OBSCN0.99608206
65BCR0.98911318
66NLK0.98874718
67IKBKB0.96177043
68ERBB30.94623319
69ATR0.94101039
70GRK70.93179168
71CASK0.93033167
72WNK40.92787009
73KSR10.90884646
74TYRO30.90784513
75CDK70.90154937
76STK390.89532099
77AKT30.86185290
78DMPK0.85453212
79ACVR1B0.82311465
80ATM0.82170471
81PKN20.80834273
82JAK30.80600164
83MTOR0.80115934
84EIF2AK20.79088051
85PLK20.77681739
86OXSR10.76209602
87BRD40.75958066
88CLK10.75816936
89STK40.74633444
90PRKCQ0.74380174
91CHUK0.72816557
92TRPM70.70501168
93IRAK10.69744236
94KIT0.68271320
95CDK20.67796321
96PLK30.65563087
97PIM10.63848514
98PRKCE0.63569175
99CSNK1G10.61572122
100NEK10.61449131
101TIE10.61064668
102PRKCG0.61062246
103PASK0.60646584
104RET0.59915591
105VRK20.59799655
106CDK60.58252605
107PRKD30.57765655
108AURKA0.57641668
109EIF2AK10.57394035
110RPS6KA50.56035739
111SGK20.55877867
112ADRBK10.55305504
113CDK10.55253661
114TRIB30.55218085
115CDK30.55191397
116FLT30.55143339
117IKBKE0.53470667
118BRSK20.52214834
119CSNK1A10.51413808
120PAK30.50287672
121CSNK1D0.49312135
122MUSK0.48534217
123TEC0.47597046
124EPHA30.47082388
125HIPK20.45854271
126WEE10.44663063
127RPS6KB10.41483052
128TYK20.41336234
129PKN10.41216685
130SGK2230.40899354
131SGK4940.40899354
132AKT10.40736409
133PRKAA10.38198213
134MAP3K50.38031853
135SYK0.38010863
136TAF10.37533629
137NUAK10.37308876
138PDGFRB0.35910239
139PRKAA20.33484621
140CSNK1A1L0.32981550
141MAPK140.32965536
142FES0.32899004
143ALK0.31484328
144DYRK30.31341266
145PAK60.30698579
146DYRK20.30674161
147PRKD20.29551127
148LYN0.29539200
149CSNK2A10.29308810
150TGFBR10.29258123
151MAPKAPK50.29040699
152MAP3K140.28777105
153NME10.27877365
154MARK20.27162420
155ABL10.27031269
156* MAPK10.26640620
157RPS6KA10.26112655
158GSK3B0.25553836
159ITK0.24461653
160SRPK10.24308173
161VRK10.23191431
162GRK60.22837599
163CSNK1E0.22737597
164SGK30.21922417
165IRAK40.21170207
166MAPK110.20302728

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.37363659
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.89482595
3Phototransduction_Homo sapiens_hsa047442.73208276
4DNA replication_Homo sapiens_hsa030302.69300932
5Protein export_Homo sapiens_hsa030602.57480275
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.48931016
7Base excision repair_Homo sapiens_hsa034102.41643017
8Basal transcription factors_Homo sapiens_hsa030222.38470895
9Mismatch repair_Homo sapiens_hsa034302.34945393
10Non-homologous end-joining_Homo sapiens_hsa034502.31643190
11RNA transport_Homo sapiens_hsa030132.30437259
12* RNA degradation_Homo sapiens_hsa030182.18926099
13Homologous recombination_Homo sapiens_hsa034402.05027675
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03184490
15Ovarian steroidogenesis_Homo sapiens_hsa049131.94639197
16Fanconi anemia pathway_Homo sapiens_hsa034601.88414579
17mRNA surveillance pathway_Homo sapiens_hsa030151.86275167
18p53 signaling pathway_Homo sapiens_hsa041151.83885264
19MicroRNAs in cancer_Homo sapiens_hsa052061.80540304
20Caffeine metabolism_Homo sapiens_hsa002321.80188499
21Circadian rhythm_Homo sapiens_hsa047101.80081824
22Oocyte meiosis_Homo sapiens_hsa041141.79392059
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.75941136
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.75136720
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.73793671
26Butanoate metabolism_Homo sapiens_hsa006501.73670677
27Oxidative phosphorylation_Homo sapiens_hsa001901.73670010
28Proteasome_Homo sapiens_hsa030501.71499947
29Pancreatic cancer_Homo sapiens_hsa052121.69178878
30Regulation of autophagy_Homo sapiens_hsa041401.68005438
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.66604717
32One carbon pool by folate_Homo sapiens_hsa006701.64398040
33Propanoate metabolism_Homo sapiens_hsa006401.63921966
34Olfactory transduction_Homo sapiens_hsa047401.60072797
35Nucleotide excision repair_Homo sapiens_hsa034201.59990292
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.56066678
37Nitrogen metabolism_Homo sapiens_hsa009101.48086099
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45054847
39Parkinsons disease_Homo sapiens_hsa050121.43016078
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38947325
41Notch signaling pathway_Homo sapiens_hsa043301.36183298
42Colorectal cancer_Homo sapiens_hsa052101.36106048
43TGF-beta signaling pathway_Homo sapiens_hsa043501.35576001
44Tryptophan metabolism_Homo sapiens_hsa003801.34282223
45Chronic myeloid leukemia_Homo sapiens_hsa052201.33619162
46Herpes simplex infection_Homo sapiens_hsa051681.32310507
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31843990
48Asthma_Homo sapiens_hsa053101.31632700
49Spliceosome_Homo sapiens_hsa030401.29794901
50Small cell lung cancer_Homo sapiens_hsa052221.28400885
51HTLV-I infection_Homo sapiens_hsa051661.27988600
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26314729
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26107079
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24513068
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.21331562
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21292500
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20297790
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17327003
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17238784
60Selenocompound metabolism_Homo sapiens_hsa004501.13279941
61Adherens junction_Homo sapiens_hsa045201.11262074
62Allograft rejection_Homo sapiens_hsa053301.10446646
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07885564
64Sulfur metabolism_Homo sapiens_hsa009201.07716783
65Lysine degradation_Homo sapiens_hsa003101.07584454
66Hippo signaling pathway_Homo sapiens_hsa043901.06761825
67Prolactin signaling pathway_Homo sapiens_hsa049171.06354032
68Viral carcinogenesis_Homo sapiens_hsa052031.05399320
69Dorso-ventral axis formation_Homo sapiens_hsa043201.04786389
70Steroid biosynthesis_Homo sapiens_hsa001001.01569445
71Collecting duct acid secretion_Homo sapiens_hsa049661.00907363
72Autoimmune thyroid disease_Homo sapiens_hsa053201.00290841
73mTOR signaling pathway_Homo sapiens_hsa041501.00272365
74Rheumatoid arthritis_Homo sapiens_hsa053230.99934246
75Hepatitis B_Homo sapiens_hsa051610.99236034
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98124655
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98079355
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96777449
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95461306
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.94501895
81Primary immunodeficiency_Homo sapiens_hsa053400.93518628
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92252915
83Purine metabolism_Homo sapiens_hsa002300.91264777
84Epstein-Barr virus infection_Homo sapiens_hsa051690.91152357
85Thyroid cancer_Homo sapiens_hsa052160.91144472
86RNA polymerase_Homo sapiens_hsa030200.90825501
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90415436
88Shigellosis_Homo sapiens_hsa051310.88138797
89FoxO signaling pathway_Homo sapiens_hsa040680.86154085
90Non-small cell lung cancer_Homo sapiens_hsa052230.85728537
91Graft-versus-host disease_Homo sapiens_hsa053320.84738928
92Toxoplasmosis_Homo sapiens_hsa051450.83357521
93Huntingtons disease_Homo sapiens_hsa050160.83103232
94Type I diabetes mellitus_Homo sapiens_hsa049400.83015890
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81937341
96Influenza A_Homo sapiens_hsa051640.81216846
97Apoptosis_Homo sapiens_hsa042100.80503976
98Measles_Homo sapiens_hsa051620.79883837
99Chemical carcinogenesis_Homo sapiens_hsa052040.79094124
100Taste transduction_Homo sapiens_hsa047420.78436611
101B cell receptor signaling pathway_Homo sapiens_hsa046620.78385302
102Leishmaniasis_Homo sapiens_hsa051400.78210748
103Choline metabolism in cancer_Homo sapiens_hsa052310.78150691
104Endometrial cancer_Homo sapiens_hsa052130.77916631
105Peroxisome_Homo sapiens_hsa041460.76944125
106Renal cell carcinoma_Homo sapiens_hsa052110.76274493
107Prostate cancer_Homo sapiens_hsa052150.76232509
108Pyrimidine metabolism_Homo sapiens_hsa002400.72457093
109Antigen processing and presentation_Homo sapiens_hsa046120.72396654
110VEGF signaling pathway_Homo sapiens_hsa043700.71782274
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.70270434
112Hedgehog signaling pathway_Homo sapiens_hsa043400.70163754
113TNF signaling pathway_Homo sapiens_hsa046680.69148428
114Pathways in cancer_Homo sapiens_hsa052000.68929072
115Legionellosis_Homo sapiens_hsa051340.67056553
116T cell receptor signaling pathway_Homo sapiens_hsa046600.67051234
117Viral myocarditis_Homo sapiens_hsa054160.66877601
118Basal cell carcinoma_Homo sapiens_hsa052170.66789024
119Alzheimers disease_Homo sapiens_hsa050100.66535552
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.66285313
121Nicotine addiction_Homo sapiens_hsa050330.65588766
122Acute myeloid leukemia_Homo sapiens_hsa052210.65134616
123Hematopoietic cell lineage_Homo sapiens_hsa046400.63243803
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63140094
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62486878
126Proteoglycans in cancer_Homo sapiens_hsa052050.62308698
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.61898996
128Vitamin B6 metabolism_Homo sapiens_hsa007500.61446689
129Primary bile acid biosynthesis_Homo sapiens_hsa001200.60730359
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59037515
131Osteoclast differentiation_Homo sapiens_hsa043800.58595954
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58561175
133Morphine addiction_Homo sapiens_hsa050320.57833972
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57704451
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.56698508
136Wnt signaling pathway_Homo sapiens_hsa043100.54841141
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54206252
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52396227
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51666003
140Bladder cancer_Homo sapiens_hsa052190.50204137
141Linoleic acid metabolism_Homo sapiens_hsa005910.49805375
142MAPK signaling pathway_Homo sapiens_hsa040100.49687928
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45785401
144Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45446159
145Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44871053
146GnRH signaling pathway_Homo sapiens_hsa049120.43895737
147Glioma_Homo sapiens_hsa052140.43809412
148Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43647658
149Phospholipase D signaling pathway_Homo sapiens_hsa040720.43419445
150Focal adhesion_Homo sapiens_hsa045100.43359202
151Ether lipid metabolism_Homo sapiens_hsa005650.43287136
152Inositol phosphate metabolism_Homo sapiens_hsa005620.42246028
153Platelet activation_Homo sapiens_hsa046110.41928827
154Leukocyte transendothelial migration_Homo sapiens_hsa046700.40960926
155Glycerolipid metabolism_Homo sapiens_hsa005610.38718555
156Metabolic pathways_Homo sapiens_hsa011000.38535222
157Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37875391
158Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36896160
159ABC transporters_Homo sapiens_hsa020100.35737043
160Arachidonic acid metabolism_Homo sapiens_hsa005900.35521051
161beta-Alanine metabolism_Homo sapiens_hsa004100.32623619

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