DCLRE1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)6.06283288
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.80328722
3replication fork processing (GO:0031297)5.30961759
4neutrophil activation involved in immune response (GO:0002283)5.18533012
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.83337297
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.83337297
7modulation by symbiont of host immune response (GO:0052553)4.83337297
8positive regulation by symbiont of host defense response (GO:0052509)4.83337297
9modulation by symbiont of host defense response (GO:0052031)4.83337297
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.83337297
11negative regulation of DNA-dependent DNA replication (GO:2000104)4.77329299
12positive regulation of gamma-delta T cell activation (GO:0046645)4.54280456
13maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.49729566
14regulation of interferon-beta biosynthetic process (GO:0045357)4.26254453
15chromatin remodeling at centromere (GO:0031055)4.23102840
16kinetochore assembly (GO:0051382)4.20313090
17kinetochore organization (GO:0051383)4.15560120
18regulation of B cell receptor signaling pathway (GO:0050855)4.08885186
19protein K6-linked ubiquitination (GO:0085020)4.08119972
20regulation of DNA endoreduplication (GO:0032875)4.06162388
21neutrophil activation (GO:0042119)4.05509442
22DNA replication checkpoint (GO:0000076)4.03442964
23regulation of nuclear cell cycle DNA replication (GO:0033262)4.02803631
24CENP-A containing nucleosome assembly (GO:0034080)3.99711635
25positive regulation of interferon-alpha production (GO:0032727)3.98227775
26recombinational repair (GO:0000725)3.96276775
27double-strand break repair via homologous recombination (GO:0000724)3.93367627
28positive regulation of B cell differentiation (GO:0045579)3.90264716
29macrophage activation involved in immune response (GO:0002281)3.85875286
30DNA catabolic process, exonucleolytic (GO:0000738)3.82978746
31granulocyte activation (GO:0036230)3.81898382
32microglial cell activation (GO:0001774)3.81430521
33response to peptidoglycan (GO:0032494)3.78763534
34regulation of interferon-alpha production (GO:0032647)3.77441280
35response to muramyl dipeptide (GO:0032495)3.76712949
36histone H2A acetylation (GO:0043968)3.76521629
37histone exchange (GO:0043486)3.73583024
38cellular response to interferon-beta (GO:0035458)3.73220775
39RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.67778425
40positive regulation of cellular amide metabolic process (GO:0034250)3.58444019
41somatic hypermutation of immunoglobulin genes (GO:0016446)3.58196611
42somatic diversification of immune receptors via somatic mutation (GO:0002566)3.58196611
43positive regulation of antigen processing and presentation (GO:0002579)3.54811435
44centriole replication (GO:0007099)3.52687667
45negative regulation of mast cell activation (GO:0033004)3.50077584
46myeloid cell activation involved in immune response (GO:0002275)3.45824407
47postreplication repair (GO:0006301)3.45781593
48response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.44034404
49response to host immune response (GO:0052572)3.44034404
50germinal center formation (GO:0002467)3.39414781
51attachment of spindle microtubules to kinetochore (GO:0008608)3.37433722
52B cell receptor signaling pathway (GO:0050853)3.33683220
53metaphase plate congression (GO:0051310)3.31453282
54negative regulation of DNA recombination (GO:0045910)3.29710085
55regulation of B cell differentiation (GO:0045577)3.29045178
56DNA deamination (GO:0045006)3.28434753
57B cell homeostasis (GO:0001782)3.27431608
58defense response to protozoan (GO:0042832)3.26967102
59positive regulation of interferon-beta production (GO:0032728)3.26208885
60positive regulation of interleukin-1 beta secretion (GO:0050718)3.25081747
61immunoglobulin mediated immune response (GO:0016064)3.24199427
62regulation of RIG-I signaling pathway (GO:0039535)3.23474433
63resolution of meiotic recombination intermediates (GO:0000712)3.23378040
64telomere maintenance via semi-conservative replication (GO:0032201)3.22412922
65exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21787367
66mitotic recombination (GO:0006312)3.21481846
67regulation of interleukin-12 biosynthetic process (GO:0045075)3.20937914
68regulation of dendritic cell antigen processing and presentation (GO:0002604)3.20072149
69eosinophil chemotaxis (GO:0048245)3.18975225
70respiratory burst (GO:0045730)3.18816135
71regulation of antigen processing and presentation (GO:0002577)3.17633665
72regulation of mast cell activation (GO:0033003)3.16701469
73nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15844995
74spindle checkpoint (GO:0031577)3.14304660
75regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.14219787
76macrophage activation (GO:0042116)3.13940279
77neutrophil mediated immunity (GO:0002446)3.13490842
78DNA ligation (GO:0006266)3.12685897
79telomere maintenance via recombination (GO:0000722)3.12587540
80histone H3-K4 trimethylation (GO:0080182)3.12279259
81regulation of alpha-beta T cell proliferation (GO:0046640)3.12033521
82pinocytosis (GO:0006907)3.12000314
83somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.11322999
84somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.11322999
85isotype switching (GO:0045190)3.11322999
86negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.10915219
87negative regulation of cell killing (GO:0031342)3.10915219
88regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.10776447
89regulation of mitotic spindle checkpoint (GO:1903504)3.10776447
90negative regulation of granulocyte differentiation (GO:0030853)3.10438755
91mast cell activation (GO:0045576)3.09503122
92myeloid dendritic cell activation (GO:0001773)3.08735192
93DNA replication-dependent nucleosome assembly (GO:0006335)3.08127009
94DNA replication-dependent nucleosome organization (GO:0034723)3.08127009
95synapsis (GO:0007129)3.07827854
96respiratory chain complex IV assembly (GO:0008535)3.07754015
97regulation of mast cell degranulation (GO:0043304)3.07505620
98DNA replication-independent nucleosome organization (GO:0034724)3.06842529
99DNA replication-independent nucleosome assembly (GO:0006336)3.06842529
100nucleotide-excision repair, DNA gap filling (GO:0006297)3.06518808
101limb bud formation (GO:0060174)3.06012293
102T cell migration (GO:0072678)3.05653643
103microtubule depolymerization (GO:0007019)3.05568295
104mitotic metaphase plate congression (GO:0007080)3.04693651
105I-kappaB kinase/NF-kappaB signaling (GO:0007249)3.03367839
106sister chromatid segregation (GO:0000819)3.02593923
107regulation of mast cell activation involved in immune response (GO:0033006)3.02305350
108response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.00875012
109response to host (GO:0075136)3.00875012
110response to host defenses (GO:0052200)3.00875012
111regulation of interleukin-1 beta secretion (GO:0050706)2.97495915
112positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.97236258
113positive regulation of interleukin-1 secretion (GO:0050716)2.96768812
114leukocyte aggregation (GO:0070486)2.96651339
115DNA-dependent DNA replication (GO:0006261)2.96053077
116cullin deneddylation (GO:0010388)2.94826956
117regulation of telomere maintenance (GO:0032204)2.94593901
118positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.94392150
119interferon-gamma-mediated signaling pathway (GO:0060333)2.94208459
120negative regulation of transcription regulatory region DNA binding (GO:2000678)2.93676451
121positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.93656181
122proteasome assembly (GO:0043248)2.93131924
123mitotic spindle checkpoint (GO:0071174)2.92827927
124regulation of gamma-delta T cell activation (GO:0046643)2.92327965
125NIK/NF-kappaB signaling (GO:0038061)2.90994425
126protein localization to kinetochore (GO:0034501)2.90844917
127type I interferon signaling pathway (GO:0060337)2.90413022
128cellular response to type I interferon (GO:0071357)2.90413022
129meiotic chromosome segregation (GO:0045132)2.90279208
130* DNA recombination (GO:0006310)2.90090155
131* double-strand break repair (GO:0006302)2.89963850
132response to protozoan (GO:0001562)2.89775513
133translesion synthesis (GO:0019985)2.89614131
134DNA strand renaturation (GO:0000733)2.89183058
135response to type I interferon (GO:0034340)2.89095617
136regulation of centriole replication (GO:0046599)2.88610140
137DNA strand elongation involved in DNA replication (GO:0006271)2.88582688
138neural tube formation (GO:0001841)2.88455912
139mitotic sister chromatid segregation (GO:0000070)2.87985031
140mature B cell differentiation (GO:0002335)2.86226911
141positive regulation of macrophage differentiation (GO:0045651)2.85906574
142myeloid leukocyte activation (GO:0002274)2.84856505
143natural killer cell mediated immunity (GO:0002228)2.84601440
144natural killer cell mediated cytotoxicity (GO:0042267)2.84601440
145cytochrome complex assembly (GO:0017004)2.84146340
146response to interferon-beta (GO:0035456)2.83646839
147eosinophil migration (GO:0072677)2.81643842
148mismatch repair (GO:0006298)2.81401971
149positive regulation of alpha-beta T cell proliferation (GO:0046641)2.80995006
150centrosome organization (GO:0051297)2.79998250
151water-soluble vitamin biosynthetic process (GO:0042364)2.78112588
152protein deneddylation (GO:0000338)2.78067558
153prenylation (GO:0097354)2.77876844
154protein prenylation (GO:0018342)2.77876844
155protein K11-linked deubiquitination (GO:0035871)2.77146781
156response to pheromone (GO:0019236)2.77100227
157monocyte chemotaxis (GO:0002548)2.76787832
158T cell mediated immunity (GO:0002456)2.75823347
159negative regulation of telomere maintenance (GO:0032205)2.75382811
160dendritic cell migration (GO:0036336)2.74761631
161double-strand break repair via nonhomologous end joining (GO:0006303)2.74567377
162non-recombinational repair (GO:0000726)2.74567377
163positive regulation of interleukin-2 production (GO:0032743)2.73317315
164adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.73215346
165response to X-ray (GO:0010165)2.72949123
166myeloid leukocyte mediated immunity (GO:0002444)2.71980837
167phagocytosis, engulfment (GO:0006911)2.71002226
168mitotic G2/M transition checkpoint (GO:0044818)2.70828505
169nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.70494373
170myeloid dendritic cell differentiation (GO:0043011)2.70195755
171telomere maintenance via telomere lengthening (GO:0010833)2.70164933
172negative regulation of mitotic sister chromatid separation (GO:2000816)2.69891978
173negative regulation of sister chromatid segregation (GO:0033046)2.69891978
174negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.69891978
175negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.69891978
176negative regulation of mitotic sister chromatid segregation (GO:0033048)2.69891978
177regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.69848530
178regulation of mitotic metaphase/anaphase transition (GO:0030071)2.69848530
179DNA strand elongation (GO:0022616)2.69538731
180reciprocal meiotic recombination (GO:0007131)2.68772426
181reciprocal DNA recombination (GO:0035825)2.68772426
182somatic diversification of immunoglobulins (GO:0016445)2.68580407
183superoxide anion generation (GO:0042554)2.67995623
184positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.67431188
185positive regulation of defense response to virus by host (GO:0002230)2.67371089
186leukocyte mediated cytotoxicity (GO:0001909)2.67000857
187L-fucose metabolic process (GO:0042354)2.66795562
188L-fucose catabolic process (GO:0042355)2.66795562
189fucose catabolic process (GO:0019317)2.66795562
190negative regulation of chromosome segregation (GO:0051985)2.66167536
191positive regulation of interleukin-12 production (GO:0032735)2.65064891
192regulation of helicase activity (GO:0051095)2.64724178
193regulation of germinal center formation (GO:0002634)2.64412194
194negative regulation of translation, ncRNA-mediated (GO:0040033)2.64256952
195regulation of translation, ncRNA-mediated (GO:0045974)2.64256952
196negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.64256952
197lymphocyte homeostasis (GO:0002260)2.64014808
198detection of other organism (GO:0098543)2.63594894
199nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.62843762
200negative T cell selection (GO:0043383)2.61892526

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.72976427
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.39929270
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.01531967
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.17292093
5* IRF8_27001747_Chip-Seq_BMDM_Mouse3.94893028
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.84823598
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.79710201
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.77151939
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.51937934
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.28660559
11* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.19812784
12ZNF274_21170338_ChIP-Seq_K562_Hela3.16048788
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.12382954
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.07519426
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.98558173
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.95483888
17GATA1_22025678_ChIP-Seq_K562_Human2.78752912
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.77930112
19* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.74300983
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.71772586
21IGF1R_20145208_ChIP-Seq_DFB_Human2.63365192
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.50133845
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.45289191
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.44701402
25VDR_22108803_ChIP-Seq_LS180_Human2.42793010
26SCL_19346495_ChIP-Seq_HPC-7_Human2.38451068
27FUS_26573619_Chip-Seq_HEK293_Human2.33901487
28ELK1_19687146_ChIP-ChIP_HELA_Human2.33226721
29RUNX_20019798_ChIP-Seq_JUKART_Human2.26692171
30STAT4_19710469_ChIP-ChIP_TH1__Mouse2.21863430
31* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.21662915
32* FOXM1_23109430_ChIP-Seq_U2OS_Human2.20875307
33* SPI1_23547873_ChIP-Seq_NB4_Human2.16811576
34TAF15_26573619_Chip-Seq_HEK293_Human2.15797450
35MYB_21317192_ChIP-Seq_ERMYB_Mouse2.12171733
36SMAD_19615063_ChIP-ChIP_OVARY_Human2.11386119
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.03887973
38P300_19829295_ChIP-Seq_ESCs_Human1.97761401
39* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82690825
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.82595060
41PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.80941589
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.80779193
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.73117587
44E2F7_22180533_ChIP-Seq_HELA_Human1.71614191
45VDR_23849224_ChIP-Seq_CD4+_Human1.70262116
46MYB_26560356_Chip-Seq_TH2_Human1.67469602
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65364563
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64876731
49VDR_24787735_ChIP-Seq_THP-1_Human1.61848766
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59533297
51PU_27001747_Chip-Seq_BMDM_Mouse1.59505232
52MYC_18940864_ChIP-ChIP_HL60_Human1.59347078
53ER_23166858_ChIP-Seq_MCF-7_Human1.59022521
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58029411
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56396605
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56204639
57SPI1_23127762_ChIP-Seq_K562_Human1.55342276
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54848181
59* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54727451
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.52317956
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49655986
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.49376406
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48425503
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48019560
65* MYB_26560356_Chip-Seq_TH1_Human1.47813207
66* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46673267
67FOXP3_21729870_ChIP-Seq_TREG_Human1.46663593
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45832117
69CBP_20019798_ChIP-Seq_JUKART_Human1.45832117
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45568636
71BCAT_22108803_ChIP-Seq_LS180_Human1.45247998
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44757000
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42932440
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42377793
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.41320622
76IRF1_19129219_ChIP-ChIP_H3396_Human1.41176329
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40876718
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39159048
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.38557106
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38254817
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38191817
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36945499
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36410060
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35752960
85BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34359094
86GBX2_23144817_ChIP-Seq_PC3_Human1.31824476
87VDR_24763502_ChIP-Seq_THP-1_Human1.29509482
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29370149
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29011645
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27206732
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.26859315
92LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26804168
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26146098
94POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25480906
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25154130
96SMAD4_21799915_ChIP-Seq_A2780_Human1.23615724
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21395573
98GATA3_26560356_Chip-Seq_TH2_Human1.20514743
99CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19836530
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19392553
101RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19140398
102SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18753485
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18053750
104GATA2_21666600_ChIP-Seq_HMVEC_Human1.17882979
105* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17738966
106SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17713897
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17690438
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.17469805
109PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17002782
110GATA3_27048872_Chip-Seq_THYMUS_Human1.16228103
111STAT3_18555785_Chip-Seq_ESCs_Mouse1.15930805
112* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15743660
113PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15437485
114NANOG_19829295_ChIP-Seq_ESCs_Human1.15429197
115SOX2_19829295_ChIP-Seq_ESCs_Human1.15429197
116HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15398640
117EZH2_27294783_Chip-Seq_NPCs_Mouse1.15004686
118TP53_22573176_ChIP-Seq_HFKS_Human1.14430603
119ETS1_20019798_ChIP-Seq_JURKAT_Human1.14103745
120JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13871785
121STAT3_23295773_ChIP-Seq_U87_Human1.13652813
122KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13283307
123SRF_21415370_ChIP-Seq_HL-1_Mouse1.13069439
124P53_22387025_ChIP-Seq_ESCs_Mouse1.12723773
125SMAD3_21741376_ChIP-Seq_EPCs_Human1.12415291
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12245112
127PIAS1_25552417_ChIP-Seq_VCAP_Human1.10275478
128NMYC_18555785_Chip-Seq_ESCs_Mouse1.09597135
129* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.09053518
130E2F1_18555785_Chip-Seq_ESCs_Mouse1.08949224
131NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08119458
132CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07706332
133TCF4_22108803_ChIP-Seq_LS180_Human1.07570410
134NANOG_18555785_Chip-Seq_ESCs_Mouse1.07205138
135P300_18555785_Chip-Seq_ESCs_Mouse1.07090686
136AR_25329375_ChIP-Seq_VCAP_Human1.06390563
137E2F1_21310950_ChIP-Seq_MCF-7_Human1.06280447
138TCF4_23295773_ChIP-Seq_U87_Human1.05754101
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04684952
140EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04382165
141NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03861871
142TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03677892
143* PU1_27457419_Chip-Seq_LIVER_Mouse1.03611966
144FLI1_21867929_ChIP-Seq_TH2_Mouse1.02984981
145MAF_26560356_Chip-Seq_TH1_Human1.02865767
146SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02273162
147CMYC_18555785_Chip-Seq_ESCs_Mouse1.00515673
148CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00207675
149TP53_16413492_ChIP-PET_HCT116_Human0.99231457
150EWS_26573619_Chip-Seq_HEK293_Human0.99216580
151SOX2_18555785_Chip-Seq_ESCs_Mouse0.98829224
152TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98709508
153POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98709508
154OCT4_18555785_Chip-Seq_ESCs_Mouse0.98463320
155ZFX_18555785_Chip-Seq_ESCs_Mouse0.98099949
156RUNX2_22187159_ChIP-Seq_PCA_Human0.98090137
157* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97634418
158SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97616826
159CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97449245
160GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97448822
161* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97337976
162NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97118204
163RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96911118
164SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96377295
165TP63_19390658_ChIP-ChIP_HaCaT_Human0.94625224
166BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93454129
167YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92813799
168ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91654089
169* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90285146
170SMAD1_18555785_Chip-Seq_ESCs_Mouse0.90124932
171* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89952218

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.54644146
2MP0001835_abnormal_antigen_presentation4.51442730
3MP0005671_abnormal_response_to3.19653802
4MP0000015_abnormal_ear_pigmentation3.14011163
5MP0005058_abnormal_lysosome_morphology3.10489255
6MP0005174_abnormal_tail_pigmentation3.00432943
7MP0002148_abnormal_hypersensitivity_rea2.99090024
8MP0001790_abnormal_immune_system2.89869487
9MP0005387_immune_system_phenotype2.89869487
10MP0001800_abnormal_humoral_immune2.87567525
11MP0002419_abnormal_innate_immunity2.83303855
12MP0005000_abnormal_immune_tolerance2.70528605
13MP0003693_abnormal_embryo_hatching2.68229747
14MP0002102_abnormal_ear_morphology2.65647543
15MP0009785_altered_susceptibility_to2.63521867
16* MP0002452_abnormal_antigen_presenting2.63343250
17MP0003436_decreased_susceptibility_to2.62083561
18MP0002723_abnormal_immune_serum2.54836295
19MP0002396_abnormal_hematopoietic_system2.54001071
20MP0005025_abnormal_response_to2.48248823
21MP0000685_abnormal_immune_system2.34255033
22* MP0001819_abnormal_immune_cell2.34223809
23* MP0002420_abnormal_adaptive_immunity2.34086858
24MP0002166_altered_tumor_susceptibility2.25928835
25MP0003111_abnormal_nucleus_morphology2.23023514
26MP0001529_abnormal_vocalization2.17844765
27MP0003195_calcinosis2.07790452
28MP0006072_abnormal_retinal_apoptosis2.05084714
29MP0005464_abnormal_platelet_physiology2.01243271
30MP0002938_white_spotting2.00203956
31MP0003718_maternal_effect1.96427252
32* MP0002398_abnormal_bone_marrow1.95275995
33MP0003172_abnormal_lysosome_physiology1.95186773
34MP0002006_tumorigenesis1.95023510
35MP0003121_genomic_imprinting1.90493124
36* MP0000716_abnormal_immune_system1.87208808
37MP0002736_abnormal_nociception_after1.83704786
38MP0005551_abnormal_eye_electrophysiolog1.83497676
39MP0002405_respiratory_system_inflammati1.83322715
40MP0000516_abnormal_urinary_system1.80946917
41MP0005367_renal/urinary_system_phenotyp1.80946917
42MP0008789_abnormal_olfactory_epithelium1.78980562
43MP0003763_abnormal_thymus_physiology1.78691328
44MP0003183_abnormal_peptide_metabolism1.78284878
45MP0000372_irregular_coat_pigmentation1.75967438
46MP0005310_abnormal_salivary_gland1.75945483
47MP0006082_CNS_inflammation1.75808562
48MP0003786_premature_aging1.74890404
49* MP0000689_abnormal_spleen_morphology1.69355175
50MP0001853_heart_inflammation1.68093920
51MP0001968_abnormal_touch/_nociception1.67803237
52MP0004510_myositis1.65849173
53MP0005253_abnormal_eye_physiology1.63486330
54MP0002751_abnormal_autonomic_nervous1.62048553
55MP0003880_abnormal_central_pattern1.59880742
56MP0008872_abnormal_physiological_respon1.58315924
57MP0002277_abnormal_respiratory_mucosa1.57952454
58MP0003724_increased_susceptibility_to1.55986851
59MP0005075_abnormal_melanosome_morpholog1.53390422
60MP0004957_abnormal_blastocyst_morpholog1.50027734
61* MP0002429_abnormal_blood_cell1.49144368
62MP0001293_anophthalmia1.47620961
63* MP0002722_abnormal_immune_system1.47375909
64MP0004147_increased_porphyrin_level1.46839447
65MP0001845_abnormal_inflammatory_respons1.44879830
66MP0002095_abnormal_skin_pigmentation1.43987126
67MP0003787_abnormal_imprinting1.42928834
68MP0009764_decreased_sensitivity_to1.42348242
69MP0001485_abnormal_pinna_reflex1.39725064
70MP0010155_abnormal_intestine_physiology1.39696831
71MP0000427_abnormal_hair_cycle1.39630811
72MP0008057_abnormal_DNA_replication1.38231106
73MP0006054_spinal_hemorrhage1.37973176
74MP0004947_skin_inflammation1.35588335
75MP0008932_abnormal_embryonic_tissue1.32741901
76MP0005409_darkened_coat_color1.32529434
77MP0000631_abnormal_neuroendocrine_gland1.31366947
78MP0008007_abnormal_cellular_replicative1.30397229
79MP0001873_stomach_inflammation1.27512475
80MP0000371_diluted_coat_color1.27037256
81MP0006035_abnormal_mitochondrial_morpho1.25011074
82MP0001533_abnormal_skeleton_physiology1.24342362
83* MP0000703_abnormal_thymus_morphology1.23470119
84MP0005171_absent_coat_pigmentation1.21288837
85MP0001929_abnormal_gametogenesis1.21064928
86MP0008469_abnormal_protein_level1.20608226
87MP0004808_abnormal_hematopoietic_stem1.20572612
88MP0002009_preneoplasia1.19051448
89MP0003646_muscle_fatigue1.16511712
90MP0003937_abnormal_limbs/digits/tail_de1.15564362
91MP0003303_peritoneal_inflammation1.15563471
92MP0001545_abnormal_hematopoietic_system1.14162136
93MP0005397_hematopoietic_system_phenotyp1.14162136
94MP0002234_abnormal_pharynx_morphology1.12507015
95MP0005394_taste/olfaction_phenotype1.11650136
96MP0005499_abnormal_olfactory_system1.11650136
97MP0001119_abnormal_female_reproductive1.09656258
98MP0006036_abnormal_mitochondrial_physio1.09356972
99MP0003567_abnormal_fetal_cardiomyocyte1.08411486
100MP0005389_reproductive_system_phenotype1.07133438
101MP0005395_other_phenotype1.05252398
102MP0002254_reproductive_system_inflammat1.05003600
103MP0008058_abnormal_DNA_repair1.05001024
104MP0001764_abnormal_homeostasis1.04182170
105MP0000653_abnormal_sex_gland1.02910015
106MP0002282_abnormal_trachea_morphology1.02412893
107MP0002653_abnormal_ependyma_morphology1.01955192
108MP0000465_gastrointestinal_hemorrhage1.01723869
109MP0009333_abnormal_splenocyte_physiolog1.01147140
110MP0004381_abnormal_hair_follicle1.00721729
111MP0009278_abnormal_bone_marrow0.99924470
112MP0001177_atelectasis0.99190388
113MP0004133_heterotaxia0.99160765
114MP0001188_hyperpigmentation0.98445756
115MP0002210_abnormal_sex_determination0.98436830
116MP0003448_altered_tumor_morphology0.96890196
117MP0005084_abnormal_gallbladder_morpholo0.96015126
118MP0004215_abnormal_myocardial_fiber0.95331559
119MP0001145_abnormal_male_reproductive0.94836291
120MP0001324_abnormal_eye_pigmentation0.93836590
121MP0002998_abnormal_bone_remodeling0.92781589
122MP0000049_abnormal_middle_ear0.92776822
123MP0009046_muscle_twitch0.92605899
124MP0001486_abnormal_startle_reflex0.92167242
125MP0008260_abnormal_autophagy0.91531353
126MP0001186_pigmentation_phenotype0.91272875
127MP0010307_abnormal_tumor_latency0.91017427
128MP0002163_abnormal_gland_morphology0.90080293
129MP0000858_altered_metastatic_potential0.89213325
130MP0002837_dystrophic_cardiac_calcinosis0.88812473
131MP0002160_abnormal_reproductive_system0.88558501
132MP0003890_abnormal_embryonic-extraembry0.88320317
133MP0001984_abnormal_olfaction0.88317268
134MP0004043_abnormal_pH_regulation0.88115604
135MP0006276_abnormal_autonomic_nervous0.87111048
136MP0002233_abnormal_nose_morphology0.85953194
137MP0002876_abnormal_thyroid_physiology0.85663443
138MP0002075_abnormal_coat/hair_pigmentati0.85537088
139MP0003191_abnormal_cellular_cholesterol0.84459743
140MP0003698_abnormal_male_reproductive0.83875466
141MP0001919_abnormal_reproductive_system0.83643208
142MP0000778_abnormal_nervous_system0.83095369
143MP0008995_early_reproductive_senescence0.82993221
144MP0009697_abnormal_copulation0.81959005
145MP0005195_abnormal_posterior_eye0.81894437
146MP0002933_joint_inflammation0.81116620
147MP0005646_abnormal_pituitary_gland0.80800822
148MP0009745_abnormal_behavioral_response0.80495643
149MP0006292_abnormal_olfactory_placode0.80058807
150MP0001986_abnormal_taste_sensitivity0.79901054
151MP0003119_abnormal_digestive_system0.79548696
152MP0003690_abnormal_glial_cell0.78582942
153MP0000647_abnormal_sebaceous_gland0.77426844
154MP0002928_abnormal_bile_duct0.76242867
155MP0003137_abnormal_impulse_conducting0.75634920
156MP0003806_abnormal_nucleotide_metabolis0.75591193
157MP0000613_abnormal_salivary_gland0.75293600
158MP0004142_abnormal_muscle_tone0.74591511
159MP0005391_vision/eye_phenotype0.74217580
160MP0002132_abnormal_respiratory_system0.73903231
161MP0004924_abnormal_behavior0.73468839
162MP0005386_behavior/neurological_phenoty0.73468839
163MP0003755_abnormal_palate_morphology0.72787132
164MP0008877_abnormal_DNA_methylation0.72244408
165MP0008875_abnormal_xenobiotic_pharmacok0.72038216
166MP0003866_abnormal_defecation0.71599862
167MP0000604_amyloidosis0.68751003
168MP0001697_abnormal_embryo_size0.68427682
169MP0003828_pulmonary_edema0.68365295
170MP0002272_abnormal_nervous_system0.68136374
171MP0000383_abnormal_hair_follicle0.66545527
172* MP0010094_abnormal_chromosome_stability0.64609089
173MP0009840_abnormal_foam_cell0.62637801
174MP0009763_increased_sensitivity_to0.60604854
175MP0003077_abnormal_cell_cycle0.59904143
176MP0005379_endocrine/exocrine_gland_phen0.59217253
177MP0003943_abnormal_hepatobiliary_system0.59156989
178MP0003300_gastrointestinal_ulcer0.57663818
179MP0000343_altered_response_to0.56729579
180MP0000490_abnormal_crypts_of0.54609687
181MP0002138_abnormal_hepatobiliary_system0.53869155

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.10947060
2Recurrent bacterial skin infections (HP:0005406)5.90467532
3Eczematoid dermatitis (HP:0000976)4.32427928
4Pancreatic cysts (HP:0001737)3.75525980
5True hermaphroditism (HP:0010459)3.75117974
6Mediastinal lymphadenopathy (HP:0100721)3.73707996
7Optic neuritis (HP:0100653)3.73042850
8Retrobulbar optic neuritis (HP:0100654)3.73042850
9Abnormality of the labia minora (HP:0012880)3.63612061
10Recurrent skin infections (HP:0001581)3.61265807
11Systemic lupus erythematosus (HP:0002725)3.61038408
12Abnormality of chromosome stability (HP:0003220)3.60199094
13* Recurrent viral infections (HP:0004429)3.52552258
14* Recurrent fungal infections (HP:0002841)3.48564770
15Pancreatic fibrosis (HP:0100732)3.47248572
16Aplasia/Hypoplasia of the uvula (HP:0010293)3.46200293
17Meckel diverticulum (HP:0002245)3.43376799
18Myositis (HP:0100614)3.42710398
19Stomatitis (HP:0010280)3.35375987
20Abnormality of the ileum (HP:0001549)3.32899911
21Molar tooth sign on MRI (HP:0002419)3.31958475
22Abnormality of midbrain morphology (HP:0002418)3.31958475
23Vacuolated lymphocytes (HP:0001922)3.26458678
24* Eosinophilia (HP:0001880)3.24024777
25Gingivitis (HP:0000230)3.20501382
26Volvulus (HP:0002580)3.18966920
27Abnormality of macrophages (HP:0004311)3.17457937
28Prostate neoplasm (HP:0100787)3.15178254
29Recurrent gram-negative bacterial infections (HP:0005420)3.11408629
30* Panhypogammaglobulinemia (HP:0003139)3.08595902
31Orchitis (HP:0100796)3.06972891
32Periodontitis (HP:0000704)3.05515522
33Elevated erythrocyte sedimentation rate (HP:0003565)2.97867791
34Abnormality of the preputium (HP:0100587)2.97384313
35Colon cancer (HP:0003003)2.93501844
36Obstructive lung disease (HP:0006536)2.92348283
37Chronic obstructive pulmonary disease (HP:0006510)2.92348283
38Chromsome breakage (HP:0040012)2.90994088
39Chronic mucocutaneous candidiasis (HP:0002728)2.90990449
40Recurrent cutaneous fungal infections (HP:0011370)2.90990449
41Meningitis (HP:0001287)2.87882450
42Agammaglobulinemia (HP:0004432)2.87643611
43* Granulocytopenia (HP:0001913)2.87556302
44Thick nail (HP:0001805)2.85864337
45Nephronophthisis (HP:0000090)2.84886628
46Abnormality of the columella (HP:0009929)2.84091807
47Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83862491
48Ependymoma (HP:0002888)2.75550915
49Abnormality of the prostate (HP:0008775)2.73141030
50Recurrent pneumonia (HP:0006532)2.71674328
51Autoimmune thrombocytopenia (HP:0001973)2.68094892
52Abnormality of T cell number (HP:0011839)2.68085302
53Pulmonary infiltrates (HP:0002113)2.67366279
54* Leukocytosis (HP:0001974)2.64978112
55Sloping forehead (HP:0000340)2.63136967
56Small intestinal stenosis (HP:0012848)2.61705897
57Duodenal stenosis (HP:0100867)2.61705897
58T lymphocytopenia (HP:0005403)2.60613128
59Vasculitis (HP:0002633)2.59080487
60Chronic diarrhea (HP:0002028)2.57263545
61Abolished electroretinogram (ERG) (HP:0000550)2.56981337
62Pendular nystagmus (HP:0012043)2.56727160
63Abnormal lung lobation (HP:0002101)2.54741473
64Increased IgM level (HP:0003496)2.54031415
65IgG deficiency (HP:0004315)2.53055425
66* Abnormality of eosinophils (HP:0001879)2.52872808
67Agnosia (HP:0010524)2.51413424
68Homocystinuria (HP:0002156)2.49633085
69Abnormality of homocysteine metabolism (HP:0010919)2.49633085
70Aplasia/Hypoplasia of the tongue (HP:0010295)2.48791358
71Glomerulonephritis (HP:0000099)2.47138042
72Methylmalonic acidemia (HP:0002912)2.46325290
73Abnormality of the renal medulla (HP:0100957)2.42058805
74Encephalitis (HP:0002383)2.41534073
75Abnormality of the duodenum (HP:0002246)2.41296682
76Increased neuronal autofluorescent lipopigment (HP:0002074)2.40380791
77Osteomyelitis (HP:0002754)2.40106306
78* Thyroiditis (HP:0100646)2.39659008
79Dysostosis multiplex (HP:0000943)2.38426054
80Small hand (HP:0200055)2.38028829
81Abnormal hair whorl (HP:0010721)2.37690603
82Abnormality of the fingertips (HP:0001211)2.36423341
83Abnormality of the renal collecting system (HP:0004742)2.34645009
84Glioma (HP:0009733)2.33152853
85Stomach cancer (HP:0012126)2.32801744
86Neoplasm of the adrenal cortex (HP:0100641)2.31575848
87Congenital stationary night blindness (HP:0007642)2.31262540
88Abnormal biliary tract physiology (HP:0012439)2.30486871
89Bile duct proliferation (HP:0001408)2.30486871
90Medial flaring of the eyebrow (HP:0010747)2.29996095
91Abnormal delayed hypersensitivity skin test (HP:0002963)2.28442333
92Abnormality of DNA repair (HP:0003254)2.27134109
93Abnormality of the renal cortex (HP:0011035)2.27065966
94Progressive inability to walk (HP:0002505)2.26096952
95Alveolar cell carcinoma (HP:0006519)2.24123111
96Keratoconjunctivitis sicca (HP:0001097)2.23312261
97Duplicated collecting system (HP:0000081)2.22298956
98Abnormality of glycolipid metabolism (HP:0010969)2.22283092
99Abnormality of liposaccharide metabolism (HP:0010968)2.22283092
100Abnormality of glycosphingolipid metabolism (HP:0004343)2.22283092
101Neoplasm of the tracheobronchial system (HP:0100552)2.19648154
102Methylmalonic aciduria (HP:0012120)2.19415349
103Chronic otitis media (HP:0000389)2.17676476
104Abnormality of the astrocytes (HP:0100707)2.17634867
105Astrocytoma (HP:0009592)2.17634867
106Birth length less than 3rd percentile (HP:0003561)2.17517810
107* Abnormality of B cell number (HP:0010975)2.16653115
108* B lymphocytopenia (HP:0010976)2.16653115
109Submucous cleft hard palate (HP:0000176)2.16539012
1103-Methylglutaconic aciduria (HP:0003535)2.13403427
111IgM deficiency (HP:0002850)2.13280064
112Increased cerebral lipofuscin (HP:0011813)2.12333964
113Gaze-evoked nystagmus (HP:0000640)2.11138818
114Ectopic kidney (HP:0000086)2.11117915
115Anencephaly (HP:0002323)2.10808479
116Recurrent lower respiratory tract infections (HP:0002783)2.09786116
117Clubbing of toes (HP:0100760)2.09193895
118Prolonged bleeding time (HP:0003010)2.09102707
119Premature loss of primary teeth (HP:0006323)2.09072641
120Generalized hypopigmentation of hair (HP:0011358)2.08321001
121Cellulitis (HP:0100658)2.08291337
122Absent frontal sinuses (HP:0002688)2.08072098
123Abnormality of the carotid arteries (HP:0005344)2.06591927
124Renal cortical cysts (HP:0000803)2.06424695
125Cystic liver disease (HP:0006706)2.06271762
126Keratoconjunctivitis (HP:0001096)2.04264136
127Osteolytic defects of the hand bones (HP:0009699)2.03931577
128Osteolytic defects of the phalanges of the hand (HP:0009771)2.03931577
129Patchy hypopigmentation of hair (HP:0011365)2.03402149
130Petechiae (HP:0000967)2.03322976
131Carpal bone hypoplasia (HP:0001498)2.01665716
132Pustule (HP:0200039)2.01257978
133Sclerocornea (HP:0000647)2.01078260
134Preaxial hand polydactyly (HP:0001177)2.01018296
135IgA deficiency (HP:0002720)2.00524493
136Chronic hepatic failure (HP:0100626)2.00394184
137Fair hair (HP:0002286)2.00291405
138Acute myeloid leukemia (HP:0004808)1.99385956
139Attenuation of retinal blood vessels (HP:0007843)1.99355403
140Hypothermia (HP:0002045)1.98547501
141Postaxial foot polydactyly (HP:0001830)1.97680538
142Hyperventilation (HP:0002883)1.96899005
143Disinhibition (HP:0000734)1.96680039
144Dandy-Walker malformation (HP:0001305)1.95620017
145Inflammation of the large intestine (HP:0002037)1.95015146
146Abnormality of aspartate family amino acid metabolism (HP:0010899)1.94264956
147Myelodysplasia (HP:0002863)1.94012399
148White forelock (HP:0002211)1.93998965
149Colitis (HP:0002583)1.92189790
150Astigmatism (HP:0000483)1.92079151
151Gingival bleeding (HP:0000225)1.91401844
152Male pseudohermaphroditism (HP:0000037)1.91260676
153Arterial thrombosis (HP:0004420)1.90256015
154Keratitis (HP:0000491)1.89859915
155Triphalangeal thumb (HP:0001199)1.89198313
156Abnormality of T cells (HP:0002843)1.89188175
157Albinism (HP:0001022)1.89147618
158Oligohydramnios (HP:0001562)1.88623417
159Patellar aplasia (HP:0006443)1.87957230
160Aplasia/Hypoplasia of the spleen (HP:0010451)1.84750847
161Rhabdomyosarcoma (HP:0002859)1.84733297
162Hypoplastic pelvis (HP:0008839)1.84422649
163Asplenia (HP:0001746)1.84407619
164Bifid tongue (HP:0010297)1.84078908
165Spinal cord lesions (HP:0100561)1.83947902
166Intestinal atresia (HP:0011100)1.82619760
167Abnormal rod and cone electroretinograms (HP:0008323)1.80344890
168Genital tract atresia (HP:0001827)1.78287104
169Aplasia/Hypoplasia of the patella (HP:0006498)1.77506939
170Congenital hepatic fibrosis (HP:0002612)1.77005183
171Supernumerary spleens (HP:0009799)1.76971109
172Abnormality of the metopic suture (HP:0005556)1.76772318
173Aganglionic megacolon (HP:0002251)1.73592685
174Inability to walk (HP:0002540)1.73590907
175Optic nerve hypoplasia (HP:0000609)1.73055047
176Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72476811
177Postaxial hand polydactyly (HP:0001162)1.72258691
178Hyperglycinemia (HP:0002154)1.71411909
179Narrow forehead (HP:0000341)1.71381002
180Nephroblastoma (Wilms tumor) (HP:0002667)1.69944900
181Congenital primary aphakia (HP:0007707)1.69398956
182Increased CSF lactate (HP:0002490)1.69358997
183Vaginal atresia (HP:0000148)1.68840464
184Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68358561
185Furrowed tongue (HP:0000221)1.68137984
186Neoplasm of the adrenal gland (HP:0100631)1.66886562
187Absent rod-and cone-mediated responses on ERG (HP:0007688)1.65867551
188Oligodactyly (hands) (HP:0001180)1.65816142
189Stenosis of the external auditory canal (HP:0000402)1.65404307
190Embryonal renal neoplasm (HP:0011794)1.65343532
191Gait imbalance (HP:0002141)1.63421061
192Oculomotor apraxia (HP:0000657)1.61926417
193Hepatocellular necrosis (HP:0001404)1.61638630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.18856220
2FRK3.93405408
3IRAK43.36956415
4TXK3.09588746
5WNK33.06789428
6IRAK32.91469016
7TYK22.84592999
8MAP4K22.78782972
9BUB12.76472284
10BLK2.70587566
11BRSK22.70132452
12MAP4K12.64581477
13TRIM282.46437309
14IKBKB2.34184532
15TAOK32.17438884
16WEE12.13052883
17MAP3K132.07646784
18PLK32.06305985
19IKBKE2.03890489
20KIT2.03782259
21RIPK42.02292195
22TNIK1.95321778
23CSF1R1.92049623
24MAPK131.86912012
25TTK1.86033625
26GRK71.81342730
27CDC71.78861724
28BMPR21.77186443
29TGFBR21.76803760
30TEC1.74237226
31EIF2AK21.72009429
32TBK11.71945188
33ZAK1.67482554
34GRK11.67287287
35ACVR1B1.63700357
36PLK21.63559618
37CHUK1.58572278
38VRK21.58412887
39YES11.55413466
40SIK21.54041993
41JAK11.50522546
42JAK31.48885874
43SYK1.46239180
44BRD41.43551000
45EIF2AK11.39114554
46NEK11.35435357
47CLK11.35338573
48ZAP701.34515980
49BTK1.29573367
50LYN1.29049303
51PLK41.27822658
52SIK31.26880564
53HCK1.22269235
54FES1.19075524
55PLK11.19065174
56LCK1.15447207
57NUAK11.12721452
58PINK11.10579759
59TGFBR11.08958382
60STK41.08918603
61BCR1.08267151
62INSRR1.08225446
63BCKDK1.08139959
64TAF11.07900613
65VRK11.05439839
66BRSK11.03635810
67ADRBK21.02016544
68MAP3K61.01214313
69ITK0.99975958
70PRPF4B0.99597149
71PIM10.98894293
72CDK120.97093565
73CSNK1G10.97083241
74MAP3K40.95936993
75STK390.95092900
76STK160.94799361
77OXSR10.94566222
78CASK0.94275008
79DYRK20.91599457
80PNCK0.89678025
81NEK60.87240643
82PAK30.84298549
83BMPR1B0.83701956
84SGK20.81879546
85CAMK1D0.80635299
86FGR0.79677818
87CDK80.79145096
88CSK0.78795120
89SRPK10.78561138
90PKN10.77991686
91CSNK1G20.76780801
92CSNK1G30.76742164
93CDK60.76708397
94ERBB30.72731865
95EPHA40.72180735
96MKNK20.68292094
97PBK0.68179734
98STK100.67929943
99CSNK1A1L0.65182473
100CDK30.63878857
101TLK10.63127507
102MAPK70.61415820
103PRKCE0.59279606
104EIF2AK30.59074874
105PIM20.58332212
106FGFR20.58249875
107AURKB0.58078647
108FLT30.57438135
109* ATR0.57322756
110MARK30.57105710
111AKT30.56405817
112WNK10.55123997
113SGK30.55020622
114CAMK1G0.53967291
115TRPM70.52035764
116MST40.51688974
117PRKCQ0.50636703
118TNK20.49782783
119IRAK10.49629828
120CAMKK20.48894049
121SGK10.48135372
122ABL10.44947869
123JAK20.44407868
124MAP2K70.43752358
125PRKAA20.43525005
126NEK90.43355954
127PRKCI0.41645081
128MINK10.41500144
129NEK20.41039814
130STK38L0.40223692
131PRKCG0.40035694
132LATS10.39548369
133MAP2K30.39270319
134NLK0.39261051
135CHEK20.39142072
136CHEK10.37195167
137EGFR0.37001857
138STK30.35917502
139RPS6KA50.34827717
140PRKCD0.34785305
141IGF1R0.34521187
142PDK20.34321849
143WNK40.34303587
144TSSK60.33909284
145CSNK1A10.33403673
146IRAK20.32991869
147FGFR30.32174098
148MAP3K120.31498335
149ADRBK10.30908727
150CCNB10.30742533
151MAPKAPK20.29428463
152* ATM0.28265169
153MKNK10.27963353
154EPHA20.27431046
155RPS6KB10.26930620
156RPS6KA40.26694003
157CDK90.26286099
158CSNK2A10.25259592
159CSNK1D0.24504439
160GRK50.24280976
161CDK10.23908109

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.54698709
2DNA replication_Homo sapiens_hsa030303.17388040
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.93308226
4* Primary immunodeficiency_Homo sapiens_hsa053402.65893223
5Proteasome_Homo sapiens_hsa030502.63125052
6Protein export_Homo sapiens_hsa030602.52366233
7Propanoate metabolism_Homo sapiens_hsa006402.46358085
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.41984425
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.39371457
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.37228903
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.32215918
12Staphylococcus aureus infection_Homo sapiens_hsa051502.31980911
13Leishmaniasis_Homo sapiens_hsa051402.29096142
14Allograft rejection_Homo sapiens_hsa053302.28133967
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.27249309
16RNA polymerase_Homo sapiens_hsa030202.23094573
17Graft-versus-host disease_Homo sapiens_hsa053322.19460100
18Measles_Homo sapiens_hsa051622.14892111
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14839668
20Osteoclast differentiation_Homo sapiens_hsa043802.14814038
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.04511399
22B cell receptor signaling pathway_Homo sapiens_hsa046622.03338961
23Nucleotide excision repair_Homo sapiens_hsa034202.00799716
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.99758867
25Phototransduction_Homo sapiens_hsa047441.97720041
26Other glycan degradation_Homo sapiens_hsa005111.91995404
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83032350
28Hematopoietic cell lineage_Homo sapiens_hsa046401.81096161
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80723542
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73494418
31Pertussis_Homo sapiens_hsa051331.71223149
32Herpes simplex infection_Homo sapiens_hsa051681.67937398
33Rheumatoid arthritis_Homo sapiens_hsa053231.65254409
34Lysosome_Homo sapiens_hsa041421.65014120
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.63118160
36Tuberculosis_Homo sapiens_hsa051521.59772720
37Cell cycle_Homo sapiens_hsa041101.59257562
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54649947
39Autoimmune thyroid disease_Homo sapiens_hsa053201.54609321
40RNA transport_Homo sapiens_hsa030131.52676960
41Influenza A_Homo sapiens_hsa051641.52246748
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.51163817
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.50348298
44Selenocompound metabolism_Homo sapiens_hsa004501.42119541
45Steroid biosynthesis_Homo sapiens_hsa001001.41974871
46Antigen processing and presentation_Homo sapiens_hsa046121.41518574
47Malaria_Homo sapiens_hsa051441.40847503
48Fatty acid elongation_Homo sapiens_hsa000621.39615719
49Nitrogen metabolism_Homo sapiens_hsa009101.39476683
50T cell receptor signaling pathway_Homo sapiens_hsa046601.38571360
51Pyrimidine metabolism_Homo sapiens_hsa002401.36573485
52Chemokine signaling pathway_Homo sapiens_hsa040621.36261126
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34164716
54Spliceosome_Homo sapiens_hsa030401.31938770
55Legionellosis_Homo sapiens_hsa051341.28742839
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.28118566
57Asthma_Homo sapiens_hsa053101.25390132
58Butanoate metabolism_Homo sapiens_hsa006501.23351394
59Apoptosis_Homo sapiens_hsa042101.22798356
60Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22334331
61TNF signaling pathway_Homo sapiens_hsa046681.20837195
62Jak-STAT signaling pathway_Homo sapiens_hsa046301.18598731
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18488114
64Fanconi anemia pathway_Homo sapiens_hsa034601.15547585
65Homologous recombination_Homo sapiens_hsa034401.15270299
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15035620
67Purine metabolism_Homo sapiens_hsa002301.14175964
68Hepatitis B_Homo sapiens_hsa051611.13977561
69Shigellosis_Homo sapiens_hsa051311.13253409
70Toxoplasmosis_Homo sapiens_hsa051451.13143353
71Phagosome_Homo sapiens_hsa041451.10274969
72Type I diabetes mellitus_Homo sapiens_hsa049401.07580363
73African trypanosomiasis_Homo sapiens_hsa051431.04355038
74Tryptophan metabolism_Homo sapiens_hsa003801.04108861
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03200270
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00503745
77Oocyte meiosis_Homo sapiens_hsa041140.98868486
78Oxidative phosphorylation_Homo sapiens_hsa001900.97428995
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96745858
80Hepatitis C_Homo sapiens_hsa051600.96081132
81Linoleic acid metabolism_Homo sapiens_hsa005910.95019481
82Salmonella infection_Homo sapiens_hsa051320.92948124
83Caffeine metabolism_Homo sapiens_hsa002320.89960076
84Parkinsons disease_Homo sapiens_hsa050120.89070992
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87646124
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85923844
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85305469
88Nicotine addiction_Homo sapiens_hsa050330.83669881
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83168370
90Arachidonic acid metabolism_Homo sapiens_hsa005900.81794938
91Epstein-Barr virus infection_Homo sapiens_hsa051690.81781148
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81346287
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80409065
94Acute myeloid leukemia_Homo sapiens_hsa052210.79668025
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78867724
96* Non-homologous end-joining_Homo sapiens_hsa034500.78693737
97Peroxisome_Homo sapiens_hsa041460.77156126
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77081782
99One carbon pool by folate_Homo sapiens_hsa006700.74017784
100Pyruvate metabolism_Homo sapiens_hsa006200.72791532
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70515401
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69339277
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68876690
104Chemical carcinogenesis_Homo sapiens_hsa052040.67998789
105Sphingolipid metabolism_Homo sapiens_hsa006000.67506577
106Retinol metabolism_Homo sapiens_hsa008300.66638445
107ABC transporters_Homo sapiens_hsa020100.65952270
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65346421
109Taste transduction_Homo sapiens_hsa047420.64842952
110Regulation of autophagy_Homo sapiens_hsa041400.64838141
111Huntingtons disease_Homo sapiens_hsa050160.64497030
112p53 signaling pathway_Homo sapiens_hsa041150.64220649
113Olfactory transduction_Homo sapiens_hsa047400.63903631
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.62853136
115Collecting duct acid secretion_Homo sapiens_hsa049660.62171875
116Fatty acid metabolism_Homo sapiens_hsa012120.62118979
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59547320
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59092608
119Chronic myeloid leukemia_Homo sapiens_hsa052200.58741788
120Vitamin B6 metabolism_Homo sapiens_hsa007500.58116624
121Renin-angiotensin system_Homo sapiens_hsa046140.57737121
122Systemic lupus erythematosus_Homo sapiens_hsa053220.57688265
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55494072
124Fatty acid degradation_Homo sapiens_hsa000710.54182867
125Hedgehog signaling pathway_Homo sapiens_hsa043400.53861416
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53738260
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.53448459
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.53337040
129Ether lipid metabolism_Homo sapiens_hsa005650.52645525
130beta-Alanine metabolism_Homo sapiens_hsa004100.52468101
131Metabolic pathways_Homo sapiens_hsa011000.51821011
132Viral myocarditis_Homo sapiens_hsa054160.51605203
133Viral carcinogenesis_Homo sapiens_hsa052030.51141787
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50514489
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48119868
136Glycerolipid metabolism_Homo sapiens_hsa005610.47507219
137Sulfur metabolism_Homo sapiens_hsa009200.45642557
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45424777
139Glutathione metabolism_Homo sapiens_hsa004800.45219957
140Lysine degradation_Homo sapiens_hsa003100.43921096
141Type II diabetes mellitus_Homo sapiens_hsa049300.43768482
142Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43105227
143mRNA surveillance pathway_Homo sapiens_hsa030150.42539411
144Prolactin signaling pathway_Homo sapiens_hsa049170.42375180
145TGF-beta signaling pathway_Homo sapiens_hsa043500.42091646
146FoxO signaling pathway_Homo sapiens_hsa040680.41163115
147Small cell lung cancer_Homo sapiens_hsa052220.41072095
148Inositol phosphate metabolism_Homo sapiens_hsa005620.40771502
149Platelet activation_Homo sapiens_hsa046110.40455900
150MicroRNAs in cancer_Homo sapiens_hsa052060.40358335
151Base excision repair_Homo sapiens_hsa034100.40323111
152Pancreatic cancer_Homo sapiens_hsa052120.40015319
153Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38937418
154Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38360331
155Basal transcription factors_Homo sapiens_hsa030220.37924374
156HTLV-I infection_Homo sapiens_hsa051660.37775671
157Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37408152
158Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35899153
159Prostate cancer_Homo sapiens_hsa052150.35263206
160MAPK signaling pathway_Homo sapiens_hsa040100.27625892
161Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27361845
1622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27244080
163RNA degradation_Homo sapiens_hsa030180.27076536
164Circadian rhythm_Homo sapiens_hsa047100.25843706
165AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.23761092
166Basal cell carcinoma_Homo sapiens_hsa052170.23509903
167Alzheimers disease_Homo sapiens_hsa050100.23293596
168Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23077452
169Drug metabolism - other enzymes_Homo sapiens_hsa009830.22469582
170Complement and coagulation cascades_Homo sapiens_hsa046100.21909286

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