DCLRE1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.14302536
2regulation of female gonad development (GO:2000194)5.66401181
3nuclear pore organization (GO:0006999)5.62546846
4mitotic metaphase plate congression (GO:0007080)5.32985442
5attachment of spindle microtubules to kinetochore (GO:0008608)5.15396257
6mitotic sister chromatid cohesion (GO:0007064)5.01062443
7DNA unwinding involved in DNA replication (GO:0006268)4.87886960
8regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.61667341
9regulation of centriole replication (GO:0046599)4.57661771
10regulation of mitotic spindle organization (GO:0060236)4.50619468
11pore complex assembly (GO:0046931)4.49543168
12regulation of nuclear cell cycle DNA replication (GO:0033262)4.43080434
13protein K6-linked ubiquitination (GO:0085020)4.42630346
14folic acid-containing compound biosynthetic process (GO:0009396)4.38319556
15protein localization to kinetochore (GO:0034501)4.38316608
16metaphase plate congression (GO:0051310)4.30464740
17CENP-A containing nucleosome assembly (GO:0034080)4.24647585
18chromatin remodeling at centromere (GO:0031055)4.17450693
19regulation of DNA endoreduplication (GO:0032875)4.16770967
20DNA replication-dependent nucleosome organization (GO:0034723)4.09312319
21DNA replication-dependent nucleosome assembly (GO:0006335)4.09312319
22regulation of DNA methylation (GO:0044030)4.02821092
23positive regulation of chromosome segregation (GO:0051984)4.01966147
24DNA replication checkpoint (GO:0000076)3.99183389
25regulation of histone H3-K9 methylation (GO:0051570)3.93731851
26meiotic chromosome segregation (GO:0045132)3.89681916
27double-strand break repair via nonhomologous end joining (GO:0006303)3.82005942
28non-recombinational repair (GO:0000726)3.82005942
29microtubule depolymerization (GO:0007019)3.81895303
30establishment of chromosome localization (GO:0051303)3.80657426
31regulation of chromosome segregation (GO:0051983)3.79494771
32female gamete generation (GO:0007292)3.79036353
33synapsis (GO:0007129)3.78632572
34regulation of spindle organization (GO:0090224)3.77257563
35positive regulation of mitotic sister chromatid separation (GO:1901970)3.72971126
36positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.72971126
37positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.72971126
38translesion synthesis (GO:0019985)3.72825573
39protein localization to chromosome, centromeric region (GO:0071459)3.71881079
40kinetochore organization (GO:0051383)3.71033778
41sister chromatid cohesion (GO:0007062)3.65604607
42protein neddylation (GO:0045116)3.63253452
43establishment of integrated proviral latency (GO:0075713)3.62658425
44negative regulation of meiosis (GO:0045835)3.60852783
45DNA damage induced protein phosphorylation (GO:0006975)3.59345602
46negative regulation of chromosome segregation (GO:0051985)3.57782300
47meiotic cell cycle (GO:0051321)3.56285309
48regulation of sister chromatid segregation (GO:0033045)3.55775402
49regulation of mitotic sister chromatid separation (GO:0010965)3.55775402
50regulation of mitotic sister chromatid segregation (GO:0033047)3.55775402
51postreplication repair (GO:0006301)3.54526580
52regulation of sister chromatid cohesion (GO:0007063)3.54352339
53negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.52445852
54negative regulation of sister chromatid segregation (GO:0033046)3.52445852
55negative regulation of mitotic sister chromatid separation (GO:2000816)3.52445852
56negative regulation of mitotic sister chromatid segregation (GO:0033048)3.52445852
57one-carbon metabolic process (GO:0006730)3.50403942
58regulation of centrosome cycle (GO:0046605)3.49972046
59piRNA metabolic process (GO:0034587)3.48725076
60kinetochore assembly (GO:0051382)3.48454507
61mitotic G2/M transition checkpoint (GO:0044818)3.47823386
62DNA ligation (GO:0006266)3.45440395
63mitotic chromosome condensation (GO:0007076)3.45227229
64centriole replication (GO:0007099)3.44239036
65DNA replication-independent nucleosome organization (GO:0034724)3.43515808
66DNA replication-independent nucleosome assembly (GO:0006336)3.43515808
67mitotic spindle assembly checkpoint (GO:0007094)3.41938415
68regulation of meiosis (GO:0040020)3.40605319
69mitotic sister chromatid segregation (GO:0000070)3.40399884
70spindle assembly checkpoint (GO:0071173)3.39261653
71DNA topological change (GO:0006265)3.39041341
72DNA double-strand break processing (GO:0000729)3.36218259
73regulation of meiosis I (GO:0060631)3.33876268
74negative regulation of DNA-dependent DNA replication (GO:2000104)3.32757770
75replication fork processing (GO:0031297)3.30277920
76DNA replication initiation (GO:0006270)3.27352382
77tryptophan metabolic process (GO:0006568)3.25480321
78replicative senescence (GO:0090399)3.25461555
79chromosome condensation (GO:0030261)3.24838049
80DNA strand elongation involved in DNA replication (GO:0006271)3.22843947
81negative regulation of meiotic cell cycle (GO:0051447)3.21086299
82somatic hypermutation of immunoglobulin genes (GO:0016446)3.20724272
83somatic diversification of immune receptors via somatic mutation (GO:0002566)3.20724272
84negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.19487760
85ATP-dependent chromatin remodeling (GO:0043044)3.17596828
86base-excision repair, AP site formation (GO:0006285)3.17179602
87chromosome organization involved in meiosis (GO:0070192)3.16448108
88histone exchange (GO:0043486)3.15482073
89response to nitrosative stress (GO:0051409)3.13159196
90DNA-dependent DNA replication (GO:0006261)3.12518750
91IMP biosynthetic process (GO:0006188)3.11049559
92ribosome assembly (GO:0042255)3.09888964
93mitotic cell cycle (GO:0000278)3.09556611
94DNA strand elongation (GO:0022616)3.08612709
95DNA methylation involved in gamete generation (GO:0043046)3.06182341
96negative regulation of histone methylation (GO:0031061)3.05407398
97regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.04198242
98chromosome segregation (GO:0007059)3.02258682
99maturation of 5.8S rRNA (GO:0000460)3.01440471
100positive regulation of DNA-dependent DNA replication (GO:2000105)2.97824371
101histone H2A monoubiquitination (GO:0035518)2.95861816
102regulation of double-strand break repair via homologous recombination (GO:0010569)2.94522478
103folic acid metabolic process (GO:0046655)2.88197901
104tetrahydrofolate metabolic process (GO:0046653)2.85666053
105chromatin assembly or disassembly (GO:0006333)2.83793071
106negative regulation of DNA-templated transcription, elongation (GO:0032785)2.83489162
107negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.83489162
108mitotic nuclear envelope disassembly (GO:0007077)2.83260230
109indolalkylamine metabolic process (GO:0006586)2.83244557
110protein localization to chromosome (GO:0034502)2.82617288
111pteridine-containing compound biosynthetic process (GO:0042559)2.79931812
112regulation of DNA-dependent DNA replication (GO:0090329)2.78713747
113S-adenosylmethionine metabolic process (GO:0046500)2.77484014
114tryptophan catabolic process (GO:0006569)2.77462735
115indole-containing compound catabolic process (GO:0042436)2.77462735
116indolalkylamine catabolic process (GO:0046218)2.77462735
117interkinetic nuclear migration (GO:0022027)2.76282054
118sister chromatid segregation (GO:0000819)2.74378004
119DNA synthesis involved in DNA repair (GO:0000731)2.70980121
120telomere maintenance via semi-conservative replication (GO:0032201)2.70001060
121spindle checkpoint (GO:0031577)2.69401775
122mitochondrial calcium ion transport (GO:0006851)2.67295471
123folic acid-containing compound metabolic process (GO:0006760)2.66638693
124regulation of RIG-I signaling pathway (GO:0039535)2.62131898
125L-phenylalanine catabolic process (GO:0006559)2.60811877
126erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.60811877
127oocyte maturation (GO:0001556)2.60669790
128telomere maintenance via recombination (GO:0000722)2.60200925
129regulation of meiotic cell cycle (GO:0051445)2.59116753
130aromatic amino acid family catabolic process (GO:0009074)2.57890658
131mismatch repair (GO:0006298)2.54655559
132telomere maintenance via telomerase (GO:0007004)2.51627766
133nucleotide-excision repair, DNA gap filling (GO:0006297)2.49830313
134telomere maintenance via telomere lengthening (GO:0010833)2.49157161
135intra-S DNA damage checkpoint (GO:0031573)2.48582895
136positive regulation of humoral immune response (GO:0002922)2.48520851
137negative regulation of cell aging (GO:0090344)2.48170104
138pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.47941105
139DNA biosynthetic process (GO:0071897)2.46251578
140microtubule anchoring (GO:0034453)2.44692604
141citrulline biosynthetic process (GO:0019240)2.44620504
142regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.44150306
143nuclear envelope disassembly (GO:0051081)2.42767449
144membrane disassembly (GO:0030397)2.42767449
145mitotic recombination (GO:0006312)2.42209341
146maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.41783668
147erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.41454208
148L-phenylalanine metabolic process (GO:0006558)2.41454208
149histone H2A ubiquitination (GO:0033522)2.40971109
150serine family amino acid biosynthetic process (GO:0009070)2.40269070
151regulation of mitotic metaphase/anaphase transition (GO:0030071)2.40201307
152NAD biosynthetic process (GO:0009435)2.40115585
153female gonad development (GO:0008585)2.39105092
154mitotic spindle checkpoint (GO:0071174)2.38198725

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.81176377
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.77127649
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.83291311
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.59051267
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.43317649
6AR_21909140_ChIP-Seq_LNCAP_Human3.25184313
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.17577785
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.05358103
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.92476514
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.65421399
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59635967
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.54515397
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.34437291
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.34252414
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.23849052
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.18028457
17RXR_22158963_ChIP-Seq_LIVER_Mouse1.98861633
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.98239123
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.96783782
20KAP1_22055183_ChIP-Seq_ESCs_Mouse1.96336754
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93967562
22MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87884106
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.83342014
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.78794616
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.77999074
26THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75703902
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.70100035
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.67661691
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.65305948
30ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61613634
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54685465
32MYC_18940864_ChIP-ChIP_HL60_Human1.54232375
33* MYC_18555785_ChIP-Seq_MESCs_Mouse1.51876852
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49696628
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46262073
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46260431
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43327781
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42686623
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.40551093
40* LXR_22158963_ChIP-Seq_LIVER_Mouse1.40051895
41* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38380933
42CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.38230433
43PPARA_22158963_ChIP-Seq_LIVER_Mouse1.36679313
44EWS_26573619_Chip-Seq_HEK293_Human1.33467585
45IRF1_19129219_ChIP-ChIP_H3396_Human1.32810909
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.32661903
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31806792
48* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31648940
49CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.31644242
50EST1_17652178_ChIP-ChIP_JURKAT_Human1.29998478
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29093976
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27320157
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26829692
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.22485342
55* DCP1A_22483619_ChIP-Seq_HELA_Human1.21876785
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20700883
57ELK1_19687146_ChIP-ChIP_HELA_Human1.20228580
58FUS_26573619_Chip-Seq_HEK293_Human1.19975895
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18926226
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18631217
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18113445
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17371830
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15814541
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15746923
65XRN2_22483619_ChIP-Seq_HELA_Human1.15527654
66MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14206233
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.13721073
68TFEB_21752829_ChIP-Seq_HELA_Human1.11426181
69KDM5A_27292631_Chip-Seq_BREAST_Human1.11114048
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09925242
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09125181
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08395393
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.07478797
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07279044
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06490129
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.03894142
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03305869
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02227481
79STAT1_17558387_ChIP-Seq_HELA_Human1.01801872
80SOX17_20123909_ChIP-Seq_XEN_Mouse1.01769701
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98288142
82VDR_23849224_ChIP-Seq_CD4+_Human0.98042430
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97749374
84CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96992002
85GABP_19822575_ChIP-Seq_HepG2_Human0.96510369
86* FOXP3_21729870_ChIP-Seq_TREG_Human0.96109159
87* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95727445
88GATA4_21415370_ChIP-Seq_HL-1_Mouse0.95622726
89ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95064482
90CDX2_22108803_ChIP-Seq_LS180_Human0.94777243
91SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94108497
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92977923
93NANOG_16153702_ChIP-ChIP_HESCs_Human0.92310213
94* WT1_19549856_ChIP-ChIP_CCG9911_Human0.91200731
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90806181
96TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90649478
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89032970
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87210006
99FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87025223
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86853363
101ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86153835
102ETS1_20019798_ChIP-Seq_JURKAT_Human0.86012195
103SOX2_16153702_ChIP-ChIP_HESCs_Human0.85551267
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84406142
105* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83249107
106TAF15_26573619_Chip-Seq_HEK293_Human0.83144348
107FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82275714
108SALL4_22934838_ChIP-ChIP_CD34+_Human0.81043435
109LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80973665
110PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80928511
111HTT_18923047_ChIP-ChIP_STHdh_Human0.80587894
112CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80470221
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79940734
114STAT3_18555785_Chip-Seq_ESCs_Mouse0.79893201
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.79868213
116SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79269335
117* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79164157
118PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.79032116
119CHD1_26751641_Chip-Seq_LNCaP_Human0.78710729
120* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78141248
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.76769017
122* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.76287072
123SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.76038474
124TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75992523
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.75146316
126NANOG_21062744_ChIP-ChIP_HESCs_Human0.74813055
127POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.74463051
128ERG_20517297_ChIP-Seq_VCAP_Human0.73631983
129HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.72864633
130RUNX1_26923725_Chip-Seq_HPCs_Mouse0.72472914
131IGF1R_20145208_ChIP-Seq_DFB_Human0.72463046
132TTF2_22483619_ChIP-Seq_HELA_Human0.72174748
133* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.72091076
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.71519818
135NMYC_18555785_Chip-Seq_ESCs_Mouse0.71499677
136CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.70638956
137NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.70385654
138RUNX1_27457419_Chip-Seq_LIVER_Mouse0.69719536
139SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.66426181
140SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.65407463
141SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.64536738
142REST_19997604_ChIP-ChIP_NEURONS_Mouse0.62851576
143ETS1_22383799_ChIP-Seq_G1ME_Mouse0.61920569

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect4.29470817
2MP0009697_abnormal_copulation3.95222952
3MP0010094_abnormal_chromosome_stability3.78523130
4MP0002139_abnormal_hepatobiliary_system3.52111988
5MP0003693_abnormal_embryo_hatching3.40212366
6MP0005451_abnormal_body_composition3.17689790
7* MP0003111_abnormal_nucleus_morphology2.93952467
8MP0008058_abnormal_DNA_repair2.87299228
9MP0005360_urolithiasis2.73314589
10MP0008057_abnormal_DNA_replication2.65300493
11MP0003077_abnormal_cell_cycle2.63953158
12MP0005464_abnormal_platelet_physiology2.59551439
13MP0005408_hypopigmentation2.57258271
14MP0005395_other_phenotype2.48931349
15MP0005365_abnormal_bile_salt2.42346961
16MP0010352_gastrointestinal_tract_polyps2.41135767
17MP0003806_abnormal_nucleotide_metabolis2.40166702
18MP0008875_abnormal_xenobiotic_pharmacok2.34814402
19MP0008877_abnormal_DNA_methylation2.30297751
20MP0001730_embryonic_growth_arrest2.26690364
21MP0001119_abnormal_female_reproductive2.17160984
22MP0005085_abnormal_gallbladder_physiolo2.11408179
23MP0003252_abnormal_bile_duct1.90292645
24MP0008007_abnormal_cellular_replicative1.84696408
25MP0004957_abnormal_blastocyst_morpholog1.82085832
26MP0000566_synostosis1.80617368
27MP0010307_abnormal_tumor_latency1.79906117
28MP0003186_abnormal_redox_activity1.65885023
29MP0008932_abnormal_embryonic_tissue1.62858438
30MP0002396_abnormal_hematopoietic_system1.61898891
31MP0003699_abnormal_female_reproductive1.61738334
32MP0005499_abnormal_olfactory_system1.59657663
33MP0005394_taste/olfaction_phenotype1.59657663
34MP0008789_abnormal_olfactory_epithelium1.58483524
35MP0005171_absent_coat_pigmentation1.56269369
36MP0003984_embryonic_growth_retardation1.51812498
37MP0002877_abnormal_melanocyte_morpholog1.49855242
38MP0010368_abnormal_lymphatic_system1.48447440
39MP0001293_anophthalmia1.48020113
40MP0006292_abnormal_olfactory_placode1.47652527
41MP0008438_abnormal_cutaneous_collagen1.47462950
42MP0002084_abnormal_developmental_patter1.46355481
43MP0002088_abnormal_embryonic_growth/wei1.43982163
44MP0005647_abnormal_sex_gland1.43643813
45MP0002102_abnormal_ear_morphology1.42129737
46MP0002080_prenatal_lethality1.41492269
47MP0006035_abnormal_mitochondrial_morpho1.37416187
48MP0004782_abnormal_surfactant_physiolog1.27319147
49MP0000358_abnormal_cell_content/1.27306240
50MP0004197_abnormal_fetal_growth/weight/1.27077181
51MP0002249_abnormal_larynx_morphology1.25104674
52MP0001919_abnormal_reproductive_system1.24450274
53MP0010678_abnormal_skin_adnexa1.23995503
54MP0002163_abnormal_gland_morphology1.23931600
55MP0010234_abnormal_vibrissa_follicle1.21953034
56MP0000653_abnormal_sex_gland1.19519102
57MP0000383_abnormal_hair_follicle1.18250559
58MP0001915_intracranial_hemorrhage1.17151778
59MP0008260_abnormal_autophagy1.16956063
60MP0002168_other_aberrant_phenotype1.15708496
61MP0003656_abnormal_erythrocyte_physiolo1.15240189
62MP0010030_abnormal_orbit_morphology1.15108913
63MP0002086_abnormal_extraembryonic_tissu1.13973088
64MP0009672_abnormal_birth_weight1.13132451
65MP0002138_abnormal_hepatobiliary_system1.10967242
66MP0010386_abnormal_urinary_bladder1.10842865
67MP0002009_preneoplasia1.08900520
68MP0003698_abnormal_male_reproductive1.06668381
69MP0001929_abnormal_gametogenesis1.06424906
70MP0001661_extended_life_span1.06261838
71MP0003279_aneurysm1.06025022
72MP0005389_reproductive_system_phenotype1.04456345
73MP0003941_abnormal_skin_development1.04103596
74MP0003195_calcinosis1.03428515
75MP0002233_abnormal_nose_morphology1.02714244
76MP0006036_abnormal_mitochondrial_physio1.01434010
77MP0010329_abnormal_lipoprotein_level0.99600154
78MP0002210_abnormal_sex_determination0.98857056
79MP0004147_increased_porphyrin_level0.98182355
80MP0005501_abnormal_skin_physiology0.97341267
81MP0000490_abnormal_crypts_of0.97025710
82MP0004264_abnormal_extraembryonic_tissu0.96861293
83MP0002653_abnormal_ependyma_morphology0.95309124
84MP0005220_abnormal_exocrine_pancreas0.94171260
85MP0003937_abnormal_limbs/digits/tail_de0.93788861
86MP0000569_abnormal_digit_pigmentation0.92854782
87* MP0005384_cellular_phenotype0.92724979
88MP0002019_abnormal_tumor_incidence0.92515113
89MP0009703_decreased_birth_body0.91534252
90MP0002697_abnormal_eye_size0.90941800
91MP0002132_abnormal_respiratory_system0.90170637
92MP0003123_paternal_imprinting0.88539555
93MP0001286_abnormal_eye_development0.88279186
94MP0002160_abnormal_reproductive_system0.88054492
95MP0005503_abnormal_tendon_morphology0.87953999
96MP0005379_endocrine/exocrine_gland_phen0.86954340
97MP0001666_abnormal_nutrient_absorption0.85155238
98MP0000350_abnormal_cell_proliferation0.84617670
99MP0008004_abnormal_stomach_pH0.84152464
100MP0009840_abnormal_foam_cell0.83975387
101MP0005083_abnormal_biliary_tract0.83732520
102MP0003950_abnormal_plasma_membrane0.83379214
103MP0005410_abnormal_fertilization0.82840166
104MP0005332_abnormal_amino_acid0.81981853
105MP0000428_abnormal_craniofacial_morphol0.81660303
106MP0005508_abnormal_skeleton_morphology0.81474949
107MP0003121_genomic_imprinting0.80235410
108MP0000609_abnormal_liver_physiology0.79953126
109MP0003566_abnormal_cell_adhesion0.78437465
110MP0005187_abnormal_penis_morphology0.78098141
111MP0002938_white_spotting0.77307709
112MP0003868_abnormal_feces_composition0.77239155
113MP0002932_abnormal_joint_morphology0.75945266
114MP0005248_abnormal_Harderian_gland0.75538948
115MP0005380_embryogenesis_phenotype0.74534463
116MP0001672_abnormal_embryogenesis/_devel0.74534463
117MP0009764_decreased_sensitivity_to0.74095054
118MP0000647_abnormal_sebaceous_gland0.73504007
119MP0004019_abnormal_vitamin_homeostasis0.72385390
120MP0009384_cardiac_valve_regurgitation0.72343226
121MP0001186_pigmentation_phenotype0.72095722
122MP0000371_diluted_coat_color0.72087099
123MP0002234_abnormal_pharynx_morphology0.71665738
124MP0002092_abnormal_eye_morphology0.71394507
125MP0005670_abnormal_white_adipose0.70485959
126MP0001764_abnormal_homeostasis0.70001754
127MP0003786_premature_aging0.68696055
128MP0004808_abnormal_hematopoietic_stem0.67912466
129MP0003567_abnormal_fetal_cardiomyocyte0.67282324
130MP0002295_abnormal_pulmonary_circulatio0.67031689
131MP0002928_abnormal_bile_duct0.66903318
132MP0003221_abnormal_cardiomyocyte_apopto0.66401730
133MP0003890_abnormal_embryonic-extraembry0.65898330
134MP0001145_abnormal_male_reproductive0.65022995
135MP0000613_abnormal_salivary_gland0.64887171
136MP0002161_abnormal_fertility/fecundity0.64835149
137MP0002060_abnormal_skin_morphology0.64340423
138MP0002085_abnormal_embryonic_tissue0.64196582
139MP0000313_abnormal_cell_death0.64030832
140MP0008775_abnormal_heart_ventricle0.62877079
141MP0000427_abnormal_hair_cycle0.62747845
142MP0001529_abnormal_vocalization0.62617227
143MP0000598_abnormal_liver_morphology0.62555340
144MP0001697_abnormal_embryo_size0.62460150
145MP0000579_abnormal_nail_morphology0.61468532
146* MP0009763_increased_sensitivity_to0.60733566
147* MP0005621_abnormal_cell_physiology0.59640968
148MP0005023_abnormal_wound_healing0.59542721
149MP0001346_abnormal_lacrimal_gland0.59220420
150MP0001545_abnormal_hematopoietic_system0.59035319
151MP0005397_hematopoietic_system_phenotyp0.59035319
152MP0004084_abnormal_cardiac_muscle0.57495418
153MP0002095_abnormal_skin_pigmentation0.56821079
154MP0005076_abnormal_cell_differentiation0.56562248
155MP0004215_abnormal_myocardial_fiber0.56351353

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.66504095
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.47723532
3Male infertility (HP:0003251)5.31640317
4Increased mean platelet volume (HP:0011877)4.74379545
5Birth length less than 3rd percentile (HP:0003561)4.54672869
6Deep venous thrombosis (HP:0002625)4.27549008
7Abnormal platelet volume (HP:0011876)4.17667974
8Volvulus (HP:0002580)3.69192908
9Abnormality of chromosome stability (HP:0003220)3.66122080
10Conjugated hyperbilirubinemia (HP:0002908)3.51907942
11Menorrhagia (HP:0000132)3.47128645
12Increased nuchal translucency (HP:0010880)3.37756338
13Papillary thyroid carcinoma (HP:0002895)3.34123190
14Prolonged bleeding time (HP:0003010)3.24977029
15Intrahepatic cholestasis (HP:0001406)3.22536348
16Osteomalacia (HP:0002749)3.22075081
17Aplasia/Hypoplasia of the uvula (HP:0010293)3.08673108
18Abnormality of pyrimidine metabolism (HP:0004353)2.98854649
19Abnormal lung lobation (HP:0002101)2.98753909
20Prolonged partial thromboplastin time (HP:0003645)2.95644715
21Abnormality of the preputium (HP:0100587)2.95184324
22Acanthocytosis (HP:0001927)2.92031379
23Petechiae (HP:0000967)2.87822937
24Meckel diverticulum (HP:0002245)2.86883460
25Hypergonadotropic hypogonadism (HP:0000815)2.83322461
26Renal cortical cysts (HP:0000803)2.75332804
27Abnormality of the ileum (HP:0001549)2.75175203
28Dyschromatopsia (HP:0007641)2.75081772
29True hermaphroditism (HP:0010459)2.74387928
30Abnormal auditory evoked potentials (HP:0006958)2.71647666
31Facial hemangioma (HP:0000329)2.68101100
32Abnormal gallbladder physiology (HP:0012438)2.63223429
33Cholecystitis (HP:0001082)2.63223429
34Breast hypoplasia (HP:0003187)2.60004002
35Cystic liver disease (HP:0006706)2.56906631
36Biliary tract neoplasm (HP:0100574)2.56504488
37Small intestinal stenosis (HP:0012848)2.56184423
38Duodenal stenosis (HP:0100867)2.56184423
39Abnormality of methionine metabolism (HP:0010901)2.53830804
40Leiomyosarcoma (HP:0100243)2.50510361
41Uterine leiomyosarcoma (HP:0002891)2.50510361
42Poikilocytosis (HP:0004447)2.48049031
43Ectopic kidney (HP:0000086)2.47434429
44Chronic bronchitis (HP:0004469)2.40840408
45Bile duct proliferation (HP:0001408)2.39104908
46Abnormal biliary tract physiology (HP:0012439)2.39104908
47Medulloblastoma (HP:0002885)2.38297467
48Abnormality of the carotid arteries (HP:0005344)2.38187569
49Thyroid carcinoma (HP:0002890)2.36872702
50Pancreatic fibrosis (HP:0100732)2.36150198
51Neoplasm of the colon (HP:0100273)2.30347240
52Joint hemorrhage (HP:0005261)2.30214465
53Transitional cell carcinoma of the bladder (HP:0006740)2.29987239
54Sloping forehead (HP:0000340)2.28535504
55Malignant gastrointestinal tract tumors (HP:0006749)2.25559796
56Gastrointestinal carcinoma (HP:0002672)2.25559796
57Abnormality of monocarboxylic acid metabolism (HP:0010996)2.24323735
58Abnormality of cochlea (HP:0000375)2.23586959
59Hypochromic microcytic anemia (HP:0004840)2.22905324
60Microglossia (HP:0000171)2.22178276
61Neoplasm of the small intestine (HP:0100833)2.20013411
62Oligohydramnios (HP:0001562)2.19366489
63Rhabdomyosarcoma (HP:0002859)2.19274468
64Colon cancer (HP:0003003)2.19198169
65Cafe-au-lait spot (HP:0000957)2.17053171
66Abnormality of lateral ventricle (HP:0030047)2.16748528
67Pancreatic cysts (HP:0001737)2.16281780
68Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.13727088
69Ovarian neoplasm (HP:0100615)2.13293292
70Clubbing of toes (HP:0100760)2.13070302
71Cortical dysplasia (HP:0002539)2.10966648
72Renal Fanconi syndrome (HP:0001994)2.10712310
73Male pseudohermaphroditism (HP:0000037)2.09884005
74Multiple enchondromatosis (HP:0005701)2.08283644
75Bladder carcinoma (HP:0002862)2.07249432
76Bladder neoplasm (HP:0009725)2.07249432
77Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07060763
78Conjunctival telangiectasia (HP:0000524)2.06826591
79Hyperlipoproteinemia (HP:0010980)2.05800815
80Progressive external ophthalmoplegia (HP:0000590)2.05321288
81Abnormality of sulfur amino acid metabolism (HP:0004339)2.05090701
82Abnormality of renal resorption (HP:0011038)2.04700930
83Patellar aplasia (HP:0006443)2.04128146
84Azoospermia (HP:0000027)2.04057383
85Abnormality of DNA repair (HP:0003254)2.03986024
86Acute myeloid leukemia (HP:0004808)2.03376827
87Abnormality of the duodenum (HP:0002246)2.02780949
88Stomach cancer (HP:0012126)2.01976041
89Pancreatic islet-cell hyperplasia (HP:0004510)2.01246633
90Abnormal spermatogenesis (HP:0008669)2.00871388
91Impulsivity (HP:0100710)2.00252324
92Insidious onset (HP:0003587)1.99945673
93Termporal pattern (HP:0011008)1.99945673
94Choanal atresia (HP:0000453)1.99884553
95Gonadotropin excess (HP:0000837)1.99250747
96Deep philtrum (HP:0002002)1.99019671
97Triphalangeal thumb (HP:0001199)1.98806252
98Ileus (HP:0002595)1.98486686
99Proximal tubulopathy (HP:0000114)1.97712361
100Embryonal neoplasm (HP:0002898)1.96709534
101Abnormality of the heme biosynthetic pathway (HP:0010472)1.94990499
102Myelodysplasia (HP:0002863)1.94511451
103Abnormality of the labia minora (HP:0012880)1.92233986
104Abnormality of the renal cortex (HP:0011035)1.91237226
105Embryonal renal neoplasm (HP:0011794)1.91179175
106Abnormality of chromosome segregation (HP:0002916)1.91072131
107Capillary hemangiomas (HP:0005306)1.89847778
108Overlapping toe (HP:0001845)1.89682223
109Nephroblastoma (Wilms tumor) (HP:0002667)1.89433198
110Central scotoma (HP:0000603)1.89390210
111Median cleft lip (HP:0000161)1.88776244
112Abnormality of glycolysis (HP:0004366)1.88479842
113Neoplasm of the adrenal cortex (HP:0100641)1.88319764
114Spinal muscular atrophy (HP:0007269)1.85194588
115Hyperbilirubinemia (HP:0002904)1.85038022
116Abnormality of the intrinsic pathway (HP:0010989)1.84881608
117Ependymoma (HP:0002888)1.83998322
118Oligodactyly (hands) (HP:0001180)1.83846819
119Adrenal hypoplasia (HP:0000835)1.83797646
120Aplasia/Hypoplasia of the patella (HP:0006498)1.82740041
121Bone marrow hypocellularity (HP:0005528)1.81784927
122Uterine neoplasm (HP:0010784)1.81357521
123Absent radius (HP:0003974)1.79766770
124Aplasia/Hypoplasia of the sternum (HP:0006714)1.79089084
125Increased serum pyruvate (HP:0003542)1.77924036
126Renal tubular acidosis (HP:0001947)1.77798800
127Postnatal microcephaly (HP:0005484)1.77738625
128Hyponatremia (HP:0002902)1.77737791
129Reticulocytopenia (HP:0001896)1.75577972
130Pulmonary fibrosis (HP:0002206)1.75481367
131Hypoglycemic coma (HP:0001325)1.75341549
132Upper limb muscle weakness (HP:0003484)1.74661191
133Hepatocellular carcinoma (HP:0001402)1.73567036
134Short middle phalanx of the 5th finger (HP:0004220)1.73518137
135Abnormality of the fetal cardiovascular system (HP:0010948)1.72885797
136Abnormal umbilical cord blood vessels (HP:0011403)1.72885797
137Single umbilical artery (HP:0001195)1.72885797
138Breech presentation (HP:0001623)1.72868936
139Neoplasm of the rectum (HP:0100743)1.72578241
140Abnormality of aromatic amino acid family metabolism (HP:0004338)1.72547693
141Hyperalaninemia (HP:0003348)1.71919936
142Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71919936
143Abnormality of alanine metabolism (HP:0010916)1.71919936
144Aplasia involving forearm bones (HP:0009822)1.71541824
145Absent forearm bone (HP:0003953)1.71541824
146Secondary amenorrhea (HP:0000869)1.71431361
147Horizontal nystagmus (HP:0000666)1.71241401
148Hypobetalipoproteinemia (HP:0003563)1.71236876
149Prostate neoplasm (HP:0100787)1.71161972
150Cutaneous melanoma (HP:0012056)1.71056146
151Renal tubular dysfunction (HP:0000124)1.70914317
152Glioma (HP:0009733)1.70476539
153Impaired platelet aggregation (HP:0003540)1.70318409
154Abnormal platelet function (HP:0011869)1.70318409
155Purpura (HP:0000979)1.69369713
156Abnormality of the anterior horn cell (HP:0006802)1.67657971
157Degeneration of anterior horn cells (HP:0002398)1.67657971
158Vascular calcification (HP:0004934)1.66749667
159Oligodactyly (HP:0012165)1.66701644
160Postaxial foot polydactyly (HP:0001830)1.66599816
161Short thumb (HP:0009778)1.65526755
162Arteriovenous malformation (HP:0100026)1.65066456
163Supernumerary spleens (HP:0009799)1.65051152
164Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.64629685
165Abnormality of nucleobase metabolism (HP:0010932)1.64225378
166Lower limb hyperreflexia (HP:0002395)1.63530164
167Optic neuritis (HP:0100653)1.63288316
168Retrobulbar optic neuritis (HP:0100654)1.63288316
169Epistaxis (HP:0000421)1.62580233

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR25.44977028
2ZAK4.37049085
3TTK4.15782459
4TAOK33.98504945
5MOS3.91486671
6MST43.54424047
7CDC73.33255277
8PLK43.30388277
9PBK3.03728209
10EIF2AK32.77173893
11TSSK62.18520533
12STK38L2.17014729
13PNCK2.12408153
14LMTK22.10804539
15CDK82.00851340
16TRIM281.95009661
17EIF2AK11.92302933
18LATS11.86742083
19PLK11.76299505
20STK101.76116075
21MAP3K61.72938172
22ACVR1B1.62742448
23NEK21.58739596
24CHEK21.54411819
25MKNK21.54013293
26BMX1.45778699
27ERBB41.44202799
28PLK31.43574757
29IRAK41.36768432
30AURKB1.30787172
31MET1.30633551
32EIF2AK21.30424247
33BRSK21.28357713
34MKNK11.24585395
35CCNB11.23250199
36CDK91.22966559
37ATR1.21245265
38VRK11.17707884
39NEK91.16536118
40TNIK1.15567052
41MAP3K141.15511227
42TLK11.12358510
43TAOK11.12272972
44SCYL21.11990133
45STK31.06187786
46MELK1.06158731
47STK161.04034932
48WEE11.03114462
49TRPM71.01969210
50LATS21.00359639
51BCKDK1.00273975
52CAMK1G0.99982965
53CDK120.99068765
54MAP3K130.98238427
55RAF10.96426991
56ERBB30.95065733
57BRAF0.94873249
58KSR10.92932150
59CDK70.91215707
60ATM0.89849796
61CHUK0.88947867
62NEK10.88132665
63MAPK130.86736997
64YES10.86383526
65MAP3K30.86111198
66MAP3K80.81137542
67AKT30.80375622
68AURKA0.78414885
69MAP3K100.75049617
70PIM10.74944660
71BUB10.74518357
72RPS6KB20.73466116
73IRAK30.72198130
74TYK20.71862559
75JAK30.70903507
76STK240.69383385
77SGK20.69365698
78PLK20.64888748
79TAF10.61906385
80ARAF0.61166329
81NLK0.61048712
82PASK0.59815797
83BCR0.58793824
84KSR20.56885517
85PRKAA20.55688223
86FGR0.54893408
87KIT0.54814504
88ABL20.54290617
89MAP3K90.53256353
90NEK60.52674785
91MUSK0.52474549
92MST1R0.51694770
93CDK40.51554962
94SRPK10.51408825
95PAK10.51329519
96CDK60.50948206
97CASK0.50709398
98CHEK10.49980098
99CDK30.48748735
100FRK0.48009518
101STK40.46989613
102PRKAA10.46742057
103DYRK20.45618340
104CDK10.44385788
105CSNK1E0.44096456
106PTK2B0.43133110
107PRKCI0.42592075
108ILK0.42388464
109NUAK10.42300217
110TAOK20.41961779
111CDK20.41195078
112CSNK2A20.40922858
113PRKDC0.40081624
114TEC0.39734260
115RPS6KA40.38921237
116FLT30.38828192
117ABL10.38579345
118IKBKE0.37055022
119BMPR1B0.36911317
120INSRR0.36608402
121IKBKB0.35941336
122MAP3K50.35468598
123CLK10.35346294
124ALK0.35037711
125MINK10.34753509
126CSNK2A10.34289985
127PIK3CG0.34163941
128CDK140.32948803
129MAP2K70.32555820
130MAP2K30.30907133
131CSNK1G10.29609689
132CDK180.29331460
133ROCK10.29103664
134BRD40.27966810
135AKT10.27188150
136DYRK30.26671353
137TNK20.26340380
138CAMK1D0.26124706
139AKT20.25807905
140BRSK10.25543831
141EEF2K0.25371039
142WNK30.24134636

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.98808920
2Non-homologous end-joining_Homo sapiens_hsa034502.92425183
3One carbon pool by folate_Homo sapiens_hsa006702.88253816
4Cell cycle_Homo sapiens_hsa041102.55613032
5Base excision repair_Homo sapiens_hsa034102.49406669
6Homologous recombination_Homo sapiens_hsa034402.47115944
7Fanconi anemia pathway_Homo sapiens_hsa034602.26837471
8Mismatch repair_Homo sapiens_hsa034302.19905770
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.14775964
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.14349244
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.05800370
12RNA degradation_Homo sapiens_hsa030182.02420292
13Ovarian steroidogenesis_Homo sapiens_hsa049131.95741737
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.91708633
15Basal transcription factors_Homo sapiens_hsa030221.85922615
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.84179091
17Vitamin B6 metabolism_Homo sapiens_hsa007501.83063422
18p53 signaling pathway_Homo sapiens_hsa041151.82919579
19Nucleotide excision repair_Homo sapiens_hsa034201.79173683
20Tryptophan metabolism_Homo sapiens_hsa003801.76622181
21Folate biosynthesis_Homo sapiens_hsa007901.76511911
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.74147333
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.67303285
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61233916
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60698377
26Steroid biosynthesis_Homo sapiens_hsa001001.57870395
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.56177511
28Pyrimidine metabolism_Homo sapiens_hsa002401.48332314
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.46559481
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.46541948
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.43103569
32Complement and coagulation cascades_Homo sapiens_hsa046101.41722506
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40928433
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.39663863
35RNA polymerase_Homo sapiens_hsa030201.38543833
36Peroxisome_Homo sapiens_hsa041461.38408166
37Selenocompound metabolism_Homo sapiens_hsa004501.37831406
38Chemical carcinogenesis_Homo sapiens_hsa052041.37233633
39beta-Alanine metabolism_Homo sapiens_hsa004101.36902829
40Proteasome_Homo sapiens_hsa030501.34574388
41Arginine biosynthesis_Homo sapiens_hsa002201.34393647
42Fatty acid degradation_Homo sapiens_hsa000711.34179388
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.31325893
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26086074
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24345014
46Retinol metabolism_Homo sapiens_hsa008301.21364599
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19582349
48Histidine metabolism_Homo sapiens_hsa003401.16145072
49Linoleic acid metabolism_Homo sapiens_hsa005911.14261753
50RNA transport_Homo sapiens_hsa030131.14156697
51Fatty acid elongation_Homo sapiens_hsa000621.11763211
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11134042
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09721781
54Arginine and proline metabolism_Homo sapiens_hsa003301.07759834
55Alcoholism_Homo sapiens_hsa050341.06497299
56Arachidonic acid metabolism_Homo sapiens_hsa005901.05537550
57Glutathione metabolism_Homo sapiens_hsa004801.05254120
58Thyroid cancer_Homo sapiens_hsa052161.04103025
59Caffeine metabolism_Homo sapiens_hsa002321.01797822
60Propanoate metabolism_Homo sapiens_hsa006401.00920039
61Carbon metabolism_Homo sapiens_hsa012000.95688431
62Lysine degradation_Homo sapiens_hsa003100.94573905
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94453916
64Viral carcinogenesis_Homo sapiens_hsa052030.93737294
65Circadian rhythm_Homo sapiens_hsa047100.92027703
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91696689
67Tyrosine metabolism_Homo sapiens_hsa003500.88510588
68Fatty acid metabolism_Homo sapiens_hsa012120.85093376
69Pentose phosphate pathway_Homo sapiens_hsa000300.83753571
70ABC transporters_Homo sapiens_hsa020100.82785102
71Vitamin digestion and absorption_Homo sapiens_hsa049770.77856626
72Purine metabolism_Homo sapiens_hsa002300.77132226
73Starch and sucrose metabolism_Homo sapiens_hsa005000.76921740
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76616375
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75420451
76Platelet activation_Homo sapiens_hsa046110.75121893
77Protein export_Homo sapiens_hsa030600.74048679
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73267912
79Adherens junction_Homo sapiens_hsa045200.71585959
80Phenylalanine metabolism_Homo sapiens_hsa003600.68986348
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66210215
82PPAR signaling pathway_Homo sapiens_hsa033200.65339799
83Gap junction_Homo sapiens_hsa045400.65264615
84Biosynthesis of amino acids_Homo sapiens_hsa012300.63925224
85mRNA surveillance pathway_Homo sapiens_hsa030150.63658656
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.62803463
87Staphylococcus aureus infection_Homo sapiens_hsa051500.60214468
88Ether lipid metabolism_Homo sapiens_hsa005650.59995661
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59355712
90N-Glycan biosynthesis_Homo sapiens_hsa005100.57594172
91Herpes simplex infection_Homo sapiens_hsa051680.57526078
92Metabolic pathways_Homo sapiens_hsa011000.56481509
93Systemic lupus erythematosus_Homo sapiens_hsa053220.54924116
94TGF-beta signaling pathway_Homo sapiens_hsa043500.53402359
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53126055
96Prostate cancer_Homo sapiens_hsa052150.51041297
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50051917
98Sulfur metabolism_Homo sapiens_hsa009200.49363507
99MicroRNAs in cancer_Homo sapiens_hsa052060.49036314
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.47545180
101Small cell lung cancer_Homo sapiens_hsa052220.47313594
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45095260
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.43695709
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42878186
105Spliceosome_Homo sapiens_hsa030400.42097728
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41781224
107Non-small cell lung cancer_Homo sapiens_hsa052230.41564773
108Colorectal cancer_Homo sapiens_hsa052100.39089088
109Pyruvate metabolism_Homo sapiens_hsa006200.38364329
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37385238
111Oocyte meiosis_Homo sapiens_hsa041140.37110037
112Butanoate metabolism_Homo sapiens_hsa006500.34403657
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33317915
114Apoptosis_Homo sapiens_hsa042100.33221416
115Endometrial cancer_Homo sapiens_hsa052130.32843583
116Hippo signaling pathway_Homo sapiens_hsa043900.31292160
117Shigellosis_Homo sapiens_hsa051310.30093818
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29545487
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29531992
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.29229822
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.28968172
122Chronic myeloid leukemia_Homo sapiens_hsa052200.28549048
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27959584
124Pancreatic cancer_Homo sapiens_hsa052120.27732174
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27612793
126Sulfur relay system_Homo sapiens_hsa041220.27406419
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26077622
128Olfactory transduction_Homo sapiens_hsa047400.25365092
129HTLV-I infection_Homo sapiens_hsa051660.21850655
130Epstein-Barr virus infection_Homo sapiens_hsa051690.21559181
131Inositol phosphate metabolism_Homo sapiens_hsa005620.21518739
132Fatty acid biosynthesis_Homo sapiens_hsa000610.21475597
133Melanoma_Homo sapiens_hsa052180.21033050
134Glioma_Homo sapiens_hsa052140.20576793
135Wnt signaling pathway_Homo sapiens_hsa043100.14632394
136Renal cell carcinoma_Homo sapiens_hsa052110.14432025
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.13659253
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.11728151

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