DCLK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of MHC class I biosynthetic process (GO:0045343)9.59904356
2regulation of establishment of cell polarity (GO:2000114)9.22993080
3sex differentiation (GO:0007548)8.95239697
4stress granule assembly (GO:0034063)8.10839492
5regulation of interleukin-13 production (GO:0032656)7.88750992
6cholesterol catabolic process (GO:0006707)7.55374671
7sterol catabolic process (GO:0016127)7.55374671
8regulation of establishment or maintenance of cell polarity (GO:0032878)7.28388810
9cerebellar Purkinje cell differentiation (GO:0021702)7.17480635
10alternative mRNA splicing, via spliceosome (GO:0000380)6.82621386
11positive regulation of vasculogenesis (GO:2001214)6.59394349
12regulation of interleukin-5 production (GO:0032674)6.50529802
13kynurenine metabolic process (GO:0070189)6.24544420
14negative regulation of receptor-mediated endocytosis (GO:0048261)6.21290258
15ADP metabolic process (GO:0046031)5.92477562
16nucleoside diphosphate catabolic process (GO:0009134)5.75380538
17indole-containing compound catabolic process (GO:0042436)5.50428485
18indolalkylamine catabolic process (GO:0046218)5.50428485
19tryptophan catabolic process (GO:0006569)5.50428485
20centrosome duplication (GO:0051298)5.47133946
21regulation of vasculogenesis (GO:2001212)5.22429233
22regulation of metalloenzyme activity (GO:0048552)5.12152363
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.97760523
24lipid particle organization (GO:0034389)4.94375376
25negative regulation of endothelial cell apoptotic process (GO:2000352)4.92089933
26synaptic vesicle maturation (GO:0016188)4.91131607
27regulation of short-term neuronal synaptic plasticity (GO:0048172)4.87747956
28somite rostral/caudal axis specification (GO:0032525)4.73195608
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.65081668
30locomotory exploration behavior (GO:0035641)4.61301755
31tryptophan metabolic process (GO:0006568)4.61112056
32bile acid biosynthetic process (GO:0006699)4.60187445
33regulation of synapse structural plasticity (GO:0051823)4.59764614
34synaptic transmission, cholinergic (GO:0007271)4.56202628
35regulation of action potential (GO:0098900)4.46931375
36positive regulation of heat generation (GO:0031652)4.41533248
37neurotransmitter-gated ion channel clustering (GO:0072578)4.37119126
38central nervous system projection neuron axonogenesis (GO:0021952)4.34261139
39vocalization behavior (GO:0071625)4.33189415
40regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.31528322
41synaptic vesicle exocytosis (GO:0016079)4.27752646
42prepulse inhibition (GO:0060134)4.24269877
43acrosome assembly (GO:0001675)4.20336728
44regulation of glutamate receptor signaling pathway (GO:1900449)4.11800084
45adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.09099513
46regulation of long-term neuronal synaptic plasticity (GO:0048169)4.06701979
47regulation of neuronal synaptic plasticity (GO:0048168)4.02608079
48glutamate secretion (GO:0014047)4.01396321
49central nervous system neuron axonogenesis (GO:0021955)4.00574873
50regulation of synaptic vesicle exocytosis (GO:2000300)4.00402930
51synaptic vesicle docking involved in exocytosis (GO:0016081)3.98997415
52cell differentiation in hindbrain (GO:0021533)3.97086968
53neurotransmitter secretion (GO:0007269)3.92986452
54behavioral response to cocaine (GO:0048148)3.91142311
55negative regulation of endothelial cell proliferation (GO:0001937)3.90539212
56seminiferous tubule development (GO:0072520)3.87219768
57synaptic transmission, dopaminergic (GO:0001963)3.83042402
58protein localization to synapse (GO:0035418)3.81794042
59response to X-ray (GO:0010165)3.77774267
60cell migration involved in gastrulation (GO:0042074)3.75861522
61protein autoprocessing (GO:0016540)3.75294951
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.69851333
63regulation of synaptic vesicle transport (GO:1902803)3.66460414
64positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.64072415
65striatum development (GO:0021756)3.63944805
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.63665010
67regulation of type 2 immune response (GO:0002828)3.63310760
68regulation of dendritic spine morphogenesis (GO:0061001)3.59094869
69positive regulation of synaptic transmission, GABAergic (GO:0032230)3.58300019
70steroid catabolic process (GO:0006706)3.57477529
71ionotropic glutamate receptor signaling pathway (GO:0035235)3.56348626
72regulation of gene silencing by miRNA (GO:0060964)3.56326938
73regulation of gene silencing by RNA (GO:0060966)3.56326938
74regulation of posttranscriptional gene silencing (GO:0060147)3.56326938
75lipid translocation (GO:0034204)3.55465555
76phospholipid translocation (GO:0045332)3.55465555
77gamma-aminobutyric acid transport (GO:0015812)3.54970982
78regulation of heat generation (GO:0031650)3.54530225
79negative regulation of T cell differentiation (GO:0045581)3.52148015
80regulation of female receptivity (GO:0045924)3.49064264
81regulation of triglyceride catabolic process (GO:0010896)3.47033327
82layer formation in cerebral cortex (GO:0021819)3.45878882
83regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.45509935
84L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.45039315
85dopamine receptor signaling pathway (GO:0007212)3.44288760
86regulation of sequestering of triglyceride (GO:0010889)3.41592137
87indolalkylamine metabolic process (GO:0006586)3.40712621
88neuronal action potential propagation (GO:0019227)3.40350337
89positive regulation of membrane potential (GO:0045838)3.39037454
90regulation of glutamate secretion (GO:0014048)3.36534766
91regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.36534164
92exploration behavior (GO:0035640)3.35644170
93neuromuscular process controlling balance (GO:0050885)3.35248102
94negative regulation of mast cell activation (GO:0033004)3.35047721
95auditory behavior (GO:0031223)3.34965843
96regulation of excitatory postsynaptic membrane potential (GO:0060079)3.34670679
97positive regulation of neurotransmitter transport (GO:0051590)3.34028009
98response to amphetamine (GO:0001975)3.32884913
99activation of protein kinase A activity (GO:0034199)3.32660299
100neuron-neuron synaptic transmission (GO:0007270)3.32455745
101amine catabolic process (GO:0009310)3.32143555
102cellular biogenic amine catabolic process (GO:0042402)3.32143555
103estrogen biosynthetic process (GO:0006703)3.30538927
104regulation of superoxide metabolic process (GO:0090322)3.29693297
105G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.29281413
106dendritic spine morphogenesis (GO:0060997)3.27177984
107negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.26512745
108purine ribonucleoside diphosphate metabolic process (GO:0009179)3.26023927
109purine nucleoside diphosphate metabolic process (GO:0009135)3.26023927
110long-term memory (GO:0007616)3.24541979
111synaptic transmission, glutamatergic (GO:0035249)3.24320986
112negative regulation of dendrite development (GO:2000171)3.23724887
113regulation of synaptic transmission, glutamatergic (GO:0051966)3.23664336
114CENP-A containing nucleosome assembly (GO:0034080)3.22638023
115female mating behavior (GO:0060180)3.21441565
116glutamate receptor signaling pathway (GO:0007215)3.20389740
117phosphatidylglycerol biosynthetic process (GO:0006655)3.18852690
118regulation of synaptic plasticity (GO:0048167)3.16737400
119adult walking behavior (GO:0007628)3.15516656
120response to lipoprotein particle (GO:0055094)3.15486741
121positive regulation of fatty acid beta-oxidation (GO:0032000)3.15200345
122cellular potassium ion homeostasis (GO:0030007)3.14503209
123neuron cell-cell adhesion (GO:0007158)3.13065493
124NAD biosynthetic process (GO:0009435)3.12719353
125response to auditory stimulus (GO:0010996)3.12577566
126regulation of postsynaptic membrane potential (GO:0060078)3.12048074
127negative regulation of dendrite morphogenesis (GO:0050774)3.11559212
128neurotransmitter transport (GO:0006836)3.08910144
129termination of RNA polymerase III transcription (GO:0006386)3.08693807
130transcription elongation from RNA polymerase III promoter (GO:0006385)3.08693807
131regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.08489496
132adenosine receptor signaling pathway (GO:0001973)3.07270375
133negative regulation of organ growth (GO:0046621)3.07072978
134piRNA metabolic process (GO:0034587)3.06917019
135glycine transport (GO:0015816)3.06662772
136positive regulation of neurotransmitter secretion (GO:0001956)3.06467578
137regulation of neurotransmitter levels (GO:0001505)3.05833045
138mating behavior (GO:0007617)3.03775603
139negative regulation of endothelial cell migration (GO:0010596)3.03738714
140aromatic amino acid family catabolic process (GO:0009074)3.01762212
141chromatin remodeling at centromere (GO:0031055)3.01426352
142positive regulation of triglyceride biosynthetic process (GO:0010867)3.00110562
143regulation of receptor internalization (GO:0002090)2.98482729
144male meiosis I (GO:0007141)2.94581789
145regulation of G0 to G1 transition (GO:0070316)2.94580640
146regulation of phospholipid biosynthetic process (GO:0071071)2.94445521
147regulation of collateral sprouting (GO:0048670)2.93953342
148endoderm formation (GO:0001706)2.93708890
149transmission of nerve impulse (GO:0019226)2.92167683
150behavioral response to ethanol (GO:0048149)2.90193539
151detection of temperature stimulus (GO:0016048)2.90175482
152regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.90087354
153regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.90087354
154regulation of dendritic spine development (GO:0060998)2.89711264
155membrane hyperpolarization (GO:0060081)2.89653462
156erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.89436876
157L-phenylalanine catabolic process (GO:0006559)2.89436876
158metallo-sulfur cluster assembly (GO:0031163)2.88778478
159iron-sulfur cluster assembly (GO:0016226)2.88778478
160negative regulation of cytosolic calcium ion concentration (GO:0051481)2.88293914
161enteric nervous system development (GO:0048484)2.87911706
162neuronal ion channel clustering (GO:0045161)2.86980042
163proline transport (GO:0015824)2.86515073
164histone H3-K4 trimethylation (GO:0080182)2.86383383
165regulation of endothelial cell apoptotic process (GO:2000351)2.84469396
166neuromuscular process controlling posture (GO:0050884)2.83896731
167behavioral response to nicotine (GO:0035095)2.82343299
168one-carbon compound transport (GO:0019755)2.80692456
169neural tube formation (GO:0001841)2.80643190
170cAMP catabolic process (GO:0006198)2.80177266
171long-term synaptic potentiation (GO:0060291)2.79832667
172behavioral defense response (GO:0002209)2.79558287
173behavioral fear response (GO:0001662)2.79558287
174regulation of neurotransmitter secretion (GO:0046928)2.77240650
175regulation of neurotransmitter transport (GO:0051588)2.77019742
176amino acid salvage (GO:0043102)2.75341445
177L-methionine salvage (GO:0071267)2.75341445
178L-methionine biosynthetic process (GO:0071265)2.75341445
179peristalsis (GO:0030432)2.74883924
180negative regulation of amino acid transport (GO:0051956)2.74288123
181L-phenylalanine metabolic process (GO:0006558)2.73866771
182erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.73866771
183auditory receptor cell stereocilium organization (GO:0060088)2.72629661
184DNA demethylation (GO:0080111)2.71536490
185regulation of neurotransmitter uptake (GO:0051580)2.70366982
186membrane depolarization during action potential (GO:0086010)2.70166931
187membrane depolarization (GO:0051899)2.69096175
188vesicle transport along microtubule (GO:0047496)2.68584001
189positive regulation of synaptic transmission (GO:0050806)2.67831270
190sodium ion export (GO:0071436)2.67643274
191positive regulation of dendritic spine development (GO:0060999)2.66737124
192regulation of protein kinase A signaling (GO:0010738)2.66029207
193glutamate metabolic process (GO:0006536)2.65688169
194visual learning (GO:0008542)2.64818421
195drinking behavior (GO:0042756)2.64195718
196regulation of memory T cell differentiation (GO:0043380)11.7640737
197negative regulation of multicellular organism growth (GO:0040015)11.1558624
198cytoplasmic mRNA processing body assembly (GO:0033962)10.7924940
199negative regulation of type 2 immune response (GO:0002829)10.0761860

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.22419301
2EZH2_22144423_ChIP-Seq_EOC_Human4.79337551
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.50831708
4VDR_22108803_ChIP-Seq_LS180_Human4.45528404
5* RARB_27405468_Chip-Seq_BRAIN_Mouse3.04481016
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.84118544
7GBX2_23144817_ChIP-Seq_PC3_Human2.83742575
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79448261
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.63858918
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54287370
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54287370
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.50143705
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49787832
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.48863184
15REST_21632747_ChIP-Seq_MESCs_Mouse2.47095485
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42408453
17DROSHA_22980978_ChIP-Seq_HELA_Human2.41565374
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39724686
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39408523
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26841732
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15199427
22ER_23166858_ChIP-Seq_MCF-7_Human2.14838503
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.13913818
24IGF1R_20145208_ChIP-Seq_DFB_Human2.13386410
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13363437
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.11973466
27ZNF274_21170338_ChIP-Seq_K562_Hela2.10065570
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.07849247
29EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.05133819
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.02031445
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99496504
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98654529
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94586872
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.91513181
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91124940
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.89392652
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.87540683
38TAF15_26573619_Chip-Seq_HEK293_Human1.82243364
39FUS_26573619_Chip-Seq_HEK293_Human1.72742469
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72183124
41AR_21572438_ChIP-Seq_LNCaP_Human1.64547520
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58827549
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.54224707
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.53974729
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53231290
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.52342061
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49446215
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46785497
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46285002
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45666757
51OCT1_27270436_Chip-Seq_PROSTATE_Human1.44457367
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41468694
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39247675
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39161441
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38711485
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37670969
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37474271
58SMAD4_21799915_ChIP-Seq_A2780_Human1.36463837
59KDM2B_26808549_Chip-Seq_REH_Human1.34797922
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.34460778
61NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.33528205
62RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26224792
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25627974
64LXR_22158963_ChIP-Seq_LIVER_Mouse1.25004966
65FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24186180
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23260735
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22546807
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.21293567
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21163428
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21057314
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20325253
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20297769
73TP53_18474530_ChIP-ChIP_U2OS_Human1.19968417
74SOX2_21211035_ChIP-Seq_LN229_Gbm1.18949673
75CDX2_22108803_ChIP-Seq_LS180_Human1.17410591
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.16277782
77KDM2B_26808549_Chip-Seq_K562_Human1.16171041
78KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15956096
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14723697
80EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14269964
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.14071410
82IRF1_19129219_ChIP-ChIP_H3396_Human1.11980238
83AR_19668381_ChIP-Seq_PC3_Human1.11624510
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10977071
85FOXA1_25329375_ChIP-Seq_VCAP_Human1.10977071
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10465333
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10044066
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09809763
89TCF4_22108803_ChIP-Seq_LS180_Human1.09691830
90P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09413438
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09061858
92CBP_20019798_ChIP-Seq_JUKART_Human1.09061858
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09039346
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08720982
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.07970627
96CRX_20693478_ChIP-Seq_RETINA_Mouse1.07542575
97TBL1_22424771_ChIP-Seq_293T_Human1.07263993
98CTCF_27219007_Chip-Seq_Bcells_Human1.05841487
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05643236
100FLI1_21867929_ChIP-Seq_TH2_Mouse1.05411586
101P300_19829295_ChIP-Seq_ESCs_Human1.04403719
102NMYC_18555785_Chip-Seq_ESCs_Mouse1.04145807
103FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04137418
104STAT3_23295773_ChIP-Seq_U87_Human1.04004974
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.03765265
106ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03054860
107AHR_22903824_ChIP-Seq_MCF-7_Human1.01453005
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01313671
109PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00266187
110AR_25329375_ChIP-Seq_VCAP_Human0.99986290
111EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99366171
112PIAS1_25552417_ChIP-Seq_VCAP_Human0.98879359
113TAL1_26923725_Chip-Seq_HPCs_Mouse0.98448497
114ESET_19884257_ChIP-Seq_ESCs_Mouse0.98403027
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98292441
116SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98240593
117RING1B_27294783_Chip-Seq_NPCs_Mouse0.98059513
118FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97967819
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97860983
120KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.97683138
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96975482
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96975482
123GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96889866
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.96803398
125TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96452322
126E2F1_18555785_Chip-Seq_ESCs_Mouse0.94405398
127SOX2_18555785_Chip-Seq_ESCs_Mouse0.94255013
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.93823919
129ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93822438
130SMAD3_21741376_ChIP-Seq_HESCs_Human0.93454619
131* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.93323889
132ARNT_22903824_ChIP-Seq_MCF-7_Human0.93150338
133* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92818971
134NCOR_22424771_ChIP-Seq_293T_Human0.92643243
135PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92355252
136GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.91789481
137* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91665141
138FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91639978
139BCAT_22108803_ChIP-Seq_LS180_Human0.90689180
140OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90468453
141RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90429005
142CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90114689
143SMAD4_21741376_ChIP-Seq_EPCs_Human0.89991255
144BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89069502
145MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88869518
146TET1_21490601_ChIP-Seq_MESCs_Mouse0.88481613
147ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88306284
148KLF4_19829295_ChIP-Seq_ESCs_Human0.87819445
149NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86406170
150ESR2_21235772_ChIP-Seq_MCF-7_Human0.85914391
151SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85426354
152TCF4_23295773_ChIP-Seq_U87_Human0.84856902
153RXR_22108803_ChIP-Seq_LS180_Human0.84804769
154UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84241636
155RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.82403431
156RUNX2_22187159_ChIP-Seq_PCA_Human0.82202366
157FOXA2_19822575_ChIP-Seq_HepG2_Human0.81439336
158ESR1_20079471_ChIP-ChIP_T-47D_Human0.81191636
159BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79210824
160* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78561217

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation6.39799725
2MP0002822_catalepsy6.30397890
3MP0004859_abnormal_synaptic_plasticity5.62988585
4MP0003880_abnormal_central_pattern3.84556561
5MP0000569_abnormal_digit_pigmentation3.74119402
6MP0003635_abnormal_synaptic_transmissio3.61413189
7MP0001986_abnormal_taste_sensitivity3.61292900
8MP0004270_analgesia3.54635119
9MP0009745_abnormal_behavioral_response3.21069200
10MP0002063_abnormal_learning/memory/cond3.03684177
11MP0005360_urolithiasis2.80769468
12MP0001968_abnormal_touch/_nociception2.71464871
13MP0002064_seizures2.71350268
14MP0002638_abnormal_pupillary_reflex2.49903980
15MP0002139_abnormal_hepatobiliary_system2.46523405
16MP0002572_abnormal_emotion/affect_behav2.42472361
17MP0009046_muscle_twitch2.40834067
18MP0002734_abnormal_mechanical_nocicepti2.35922554
19MP0005253_abnormal_eye_physiology2.35476726
20MP0001486_abnormal_startle_reflex2.34501677
21MP0005085_abnormal_gallbladder_physiolo2.31256519
22MP0002272_abnormal_nervous_system2.29024314
23MP0003890_abnormal_embryonic-extraembry2.25049772
24MP0000371_diluted_coat_color2.24060318
25MP0001984_abnormal_olfaction2.22243975
26MP0002736_abnormal_nociception_after2.03731715
27MP0001529_abnormal_vocalization1.99768900
28MP0005423_abnormal_somatic_nervous1.94685681
29MP0005647_abnormal_sex_gland1.88366427
30MP0001501_abnormal_sleep_pattern1.87410717
31MP0002909_abnormal_adrenal_gland1.86280905
32MP0003329_amyloid_beta_deposits1.85814346
33MP0006072_abnormal_retinal_apoptosis1.84861066
34MP0005646_abnormal_pituitary_gland1.82600458
35MP0002735_abnormal_chemical_nociception1.82388026
36MP0002733_abnormal_thermal_nociception1.80911142
37MP0003119_abnormal_digestive_system1.78838466
38MP0008875_abnormal_xenobiotic_pharmacok1.76791446
39MP0001970_abnormal_pain_threshold1.75643869
40MP0002837_dystrophic_cardiac_calcinosis1.71088660
41MP0005365_abnormal_bile_salt1.69437802
42MP0003137_abnormal_impulse_conducting1.64843903
43MP0003172_abnormal_lysosome_physiology1.64803103
44MP0009780_abnormal_chondrocyte_physiolo1.63569804
45MP0005386_behavior/neurological_phenoty1.61792900
46MP0004924_abnormal_behavior1.61792900
47MP0001440_abnormal_grooming_behavior1.61052677
48MP0003646_muscle_fatigue1.56705280
49MP0006035_abnormal_mitochondrial_morpho1.54118610
50MP0003136_yellow_coat_color1.53682540
51MP0004858_abnormal_nervous_system1.52692829
52MP0002067_abnormal_sensory_capabilities1.50385592
53MP0002557_abnormal_social/conspecific_i1.47700908
54MP0006276_abnormal_autonomic_nervous1.46969418
55MP0003879_abnormal_hair_cell1.44667993
56MP0004811_abnormal_neuron_physiology1.42668410
57MP0005334_abnormal_fat_pad1.42140049
58MP0004885_abnormal_endolymph1.40373263
59MP0002102_abnormal_ear_morphology1.38765464
60MP0010234_abnormal_vibrissa_follicle1.36996055
61MP0008872_abnormal_physiological_respon1.36917673
62MP0003718_maternal_effect1.36858491
63MP0009384_cardiac_valve_regurgitation1.35265436
64MP0002184_abnormal_innervation1.34780923
65MP0003633_abnormal_nervous_system1.33480382
66MP0008569_lethality_at_weaning1.32947952
67MP0008874_decreased_physiological_sensi1.31537265
68MP0003186_abnormal_redox_activity1.31332712
69MP0005535_abnormal_body_temperature1.25637041
70MP0003075_altered_response_to1.25602430
71MP0005332_abnormal_amino_acid1.20529549
72MP0002066_abnormal_motor_capabilities/c1.20238768
73MP0010329_abnormal_lipoprotein_level1.19090443
74MP0003950_abnormal_plasma_membrane1.17604703
75MP0000427_abnormal_hair_cycle1.17387960
76MP0000955_abnormal_spinal_cord1.16050289
77MP0003252_abnormal_bile_duct1.13836821
78MP0001905_abnormal_dopamine_level1.10320840
79MP0004510_myositis1.09909658
80MP0000778_abnormal_nervous_system1.08286141
81MP0003195_calcinosis1.06650041
82MP0008961_abnormal_basal_metabolism1.06537968
83MP0002882_abnormal_neuron_morphology1.05851884
84MP0000604_amyloidosis1.05354946
85MP0003631_nervous_system_phenotype1.05224714
86MP0004043_abnormal_pH_regulation1.02512681
87MP0002069_abnormal_eating/drinking_beha1.02089285
88MP0002282_abnormal_trachea_morphology1.01845890
89MP0003935_abnormal_craniofacial_develop1.00632237
90MP0005167_abnormal_blood-brain_barrier1.00103578
91MP0003690_abnormal_glial_cell0.99399907
92MP0002234_abnormal_pharynx_morphology0.98806306
93MP0005645_abnormal_hypothalamus_physiol0.98765676
94MP0001502_abnormal_circadian_rhythm0.98029149
95MP0001177_atelectasis0.96585984
96MP0000013_abnormal_adipose_tissue0.93612684
97MP0002751_abnormal_autonomic_nervous0.91684749
98MP0000653_abnormal_sex_gland0.91148523
99MP0004142_abnormal_muscle_tone0.89942164
100MP0005391_vision/eye_phenotype0.88862784
101MP0004264_abnormal_extraembryonic_tissu0.85764378
102MP0005499_abnormal_olfactory_system0.85629417
103MP0005394_taste/olfaction_phenotype0.85629417
104MP0005410_abnormal_fertilization0.84675396
105MP0004133_heterotaxia0.83731361
106MP0002229_neurodegeneration0.82520523
107MP0000749_muscle_degeneration0.82478442
108MP0005584_abnormal_enzyme/coenzyme_acti0.82262011
109MP0005174_abnormal_tail_pigmentation0.81026473
110MP0004085_abnormal_heartbeat0.80904038
111MP0005083_abnormal_biliary_tract0.80519808
112MP0001765_abnormal_ion_homeostasis0.80463389
113MP0000383_abnormal_hair_follicle0.80359817
114MP0001730_embryonic_growth_arrest0.79645313
115MP0002075_abnormal_coat/hair_pigmentati0.79452752
116MP0002876_abnormal_thyroid_physiology0.79157170
117MP0001666_abnormal_nutrient_absorption0.78393454
118MP0010386_abnormal_urinary_bladder0.77437888
119MP0002090_abnormal_vision0.77319509
120MP0002693_abnormal_pancreas_physiology0.77055244
121MP0002152_abnormal_brain_morphology0.77004635
122MP0004019_abnormal_vitamin_homeostasis0.76355665
123MP0008877_abnormal_DNA_methylation0.75521347
124MP0000751_myopathy0.74412655
125MP0002118_abnormal_lipid_homeostasis0.73759438
126MP0004381_abnormal_hair_follicle0.73444499
127MP0002084_abnormal_developmental_patter0.73139804
128MP0000920_abnormal_myelination0.72595101
129MP0004742_abnormal_vestibular_system0.71703694
130MP0005310_abnormal_salivary_gland0.71528077
131MP0009250_abnormal_appendicular_skeleto0.70973492
132MP0005636_abnormal_mineral_homeostasis0.69718444
133MP0002210_abnormal_sex_determination0.68385336
134MP0000631_abnormal_neuroendocrine_gland0.68379970
135MP0001145_abnormal_male_reproductive0.67816723
136MP0005084_abnormal_gallbladder_morpholo0.67815650
137MP0008770_decreased_survivor_rate0.67665282
138MP0000428_abnormal_craniofacial_morphol0.67372582
139MP0003283_abnormal_digestive_organ0.67251958
140MP0005075_abnormal_melanosome_morpholog0.66584870
141MP0001764_abnormal_homeostasis0.66162579
142MP0002161_abnormal_fertility/fecundity0.65541593
143MP0002163_abnormal_gland_morphology0.65365903
144MP0003936_abnormal_reproductive_system0.64337441
145MP0005409_darkened_coat_color0.64271695
146MP0002752_abnormal_somatic_nervous0.63990873
147MP0005620_abnormal_muscle_contractility0.63523984
148MP0005166_decreased_susceptibility_to0.63318543
149MP0005551_abnormal_eye_electrophysiolog0.60615218
150MP0003634_abnormal_glial_cell0.60382369
151MP0001963_abnormal_hearing_physiology0.59730244
152MP0003632_abnormal_nervous_system0.58000146
153MP0003868_abnormal_feces_composition0.57116341
154MP0000026_abnormal_inner_ear0.57115811
155MP0001119_abnormal_female_reproductive0.56995048
156MP0001485_abnormal_pinna_reflex0.56977684
157MP0006292_abnormal_olfactory_placode0.56633230
158MP0001324_abnormal_eye_pigmentation0.56153730
159MP0001756_abnormal_urination0.55545766
160MP0001664_abnormal_digestion0.54136362
161MP0000230_abnormal_systemic_arterial0.53908925
162MP0004130_abnormal_muscle_cell0.52358668
163MP0002078_abnormal_glucose_homeostasis0.49350913

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.80877665
2Prostate neoplasm (HP:0100787)7.37346959
3Focal motor seizures (HP:0011153)6.26033433
4Pendular nystagmus (HP:0012043)6.00727905
5Abnormality of the hepatic vasculature (HP:0006707)5.39647309
6Slow saccadic eye movements (HP:0000514)5.25548108
7Focal seizures (HP:0007359)4.93170923
8Postural tremor (HP:0002174)4.84037218
9Limb ataxia (HP:0002070)4.18908177
10Torticollis (HP:0000473)4.06828089
11Severe visual impairment (HP:0001141)4.06322178
12Hypochromic microcytic anemia (HP:0004840)3.99501005
13Action tremor (HP:0002345)3.79715665
14Visual hallucinations (HP:0002367)3.75087324
15Focal dystonia (HP:0004373)3.66571412
16Craniofacial dystonia (HP:0012179)3.66155772
17Abnormality of the prostate (HP:0008775)3.55752162
18Generalized tonic-clonic seizures (HP:0002069)3.48618940
19Impaired proprioception (HP:0010831)3.44241591
20Abnormality of macular pigmentation (HP:0008002)3.41878761
21Absence seizures (HP:0002121)3.37802102
22Impaired vibration sensation in the lower limbs (HP:0002166)3.37429473
23Anxiety (HP:0000739)3.33063613
24Epileptic encephalopathy (HP:0200134)3.28561124
25Poor eye contact (HP:0000817)3.27481374
26Atonic seizures (HP:0010819)3.25539996
27Febrile seizures (HP:0002373)3.15696038
28Ankle clonus (HP:0011448)3.13844086
29Impaired social interactions (HP:0000735)3.12253331
30Abnormal social behavior (HP:0012433)3.12253331
31Dialeptic seizures (HP:0011146)3.10048328
32Keratoconus (HP:0000563)3.07402150
33Increased corneal curvature (HP:0100692)3.07402150
34Abnormality of aromatic amino acid family metabolism (HP:0004338)3.05641445
35Hyperventilation (HP:0002883)3.01450933
36Depression (HP:0000716)2.93824237
37Status epilepticus (HP:0002133)2.93649468
38Resting tremor (HP:0002322)2.92354825
39Bilateral microphthalmos (HP:0007633)2.91249925
40Postnatal microcephaly (HP:0005484)2.88466669
41Gout (HP:0001997)2.87238081
42Urinary bladder sphincter dysfunction (HP:0002839)2.86052069
43Dysdiadochokinesis (HP:0002075)2.85987599
44Annular pancreas (HP:0001734)2.84538475
45Deep venous thrombosis (HP:0002625)2.81987135
46Abnormality of the lower motor neuron (HP:0002366)2.80845691
47Urinary urgency (HP:0000012)2.80302766
48Abnormal eating behavior (HP:0100738)2.80077318
49Termporal pattern (HP:0011008)2.78646122
50Insidious onset (HP:0003587)2.78646122
51Rib fusion (HP:0000902)2.75259888
52Postural instability (HP:0002172)2.75236210
53Supranuclear gaze palsy (HP:0000605)2.74615486
54Dysmetria (HP:0001310)2.74410423
55Abnormality of ocular smooth pursuit (HP:0000617)2.72607208
56Areflexia of lower limbs (HP:0002522)2.67711351
57Broad-based gait (HP:0002136)2.67329232
58Vitreoretinal degeneration (HP:0000655)2.62332004
59Delayed CNS myelination (HP:0002188)2.60847434
60Progressive cerebellar ataxia (HP:0002073)2.56806991
61Gaze-evoked nystagmus (HP:0000640)2.53043749
62Neurofibrillary tangles (HP:0002185)2.46173622
63Scanning speech (HP:0002168)2.45733923
64Impaired vibratory sensation (HP:0002495)2.44995945
65Chorioretinal atrophy (HP:0000533)2.44233881
66Intention tremor (HP:0002080)2.44056879
67Amblyopia (HP:0000646)2.44044510
68Abnormality of vision evoked potentials (HP:0000649)2.43720007
69Spastic gait (HP:0002064)2.34917240
70Decreased muscle mass (HP:0003199)2.33255247
71Cerebral inclusion bodies (HP:0100314)2.33191647
72Papilledema (HP:0001085)2.31601675
73Xanthomatosis (HP:0000991)2.31264011
74Dysmetric saccades (HP:0000641)2.29817592
75Bradykinesia (HP:0002067)2.26958952
76Abnormality of saccadic eye movements (HP:0000570)2.26158996
77Neonatal onset (HP:0003623)2.25624659
78Sensorimotor neuropathy (HP:0007141)2.24017505
79Clumsiness (HP:0002312)2.23647872
80Severe Myopia (HP:0011003)2.22483678
81Stereotypic behavior (HP:0000733)2.20993359
82Decreased central vision (HP:0007663)2.20958095
83Ketosis (HP:0001946)2.20632384
84Limb dystonia (HP:0002451)2.20118245
85Biliary tract neoplasm (HP:0100574)2.17879931
86Clonus (HP:0002169)2.12737829
87Abnormality of glutamine family amino acid metabolism (HP:0010902)2.11928149
88Truncal ataxia (HP:0002078)2.11844535
89Intrahepatic cholestasis (HP:0001406)2.11723413
90Oculomotor apraxia (HP:0000657)2.10499379
91Abolished electroretinogram (ERG) (HP:0000550)2.09996019
92Epileptiform EEG discharges (HP:0011182)2.08968511
93EEG with generalized epileptiform discharges (HP:0011198)2.08809128
94Retinitis pigmentosa (HP:0000510)2.08424463
95Proximal tubulopathy (HP:0000114)2.04912761
96Hypochromic anemia (HP:0001931)2.04483065
97Abnormality of male internal genitalia (HP:0000022)2.03597797
98Increased circulating renin level (HP:0000848)2.03514659
99Impaired pain sensation (HP:0007328)2.00587353
100Abnormality of pain sensation (HP:0010832)2.00587353
101Abnormality of monocarboxylic acid metabolism (HP:0010996)2.00235945
102Genetic anticipation (HP:0003743)11.1964878
103Hyperglycinemia (HP:0002154)1.99899593
104Hypsarrhythmia (HP:0002521)1.99512608
105Ankyloglossia (HP:0010296)1.99231195
106Ketoacidosis (HP:0001993)1.97364582
107Hyperlipoproteinemia (HP:0010980)1.96521896
108Axonal loss (HP:0003447)1.96496285
109Mutism (HP:0002300)1.96287574
110Protruding tongue (HP:0010808)1.96142789
111Pheochromocytoma (HP:0002666)1.95938529
112Fair hair (HP:0002286)1.92230197
113Lower limb muscle weakness (HP:0007340)1.91867518
114Generalized myoclonic seizures (HP:0002123)1.91814859
115Hypobetalipoproteinemia (HP:0003563)1.89625267
116Ventricular fibrillation (HP:0001663)1.88437249
117Hammertoe (HP:0001765)1.88427640
118Abnormality of the corticospinal tract (HP:0002492)1.88255311
119Abnormal gallbladder physiology (HP:0012438)1.88246110
120Cholecystitis (HP:0001082)1.88246110
121Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87319759
122Lower limb asymmetry (HP:0100559)1.86664960
123Megalencephaly (HP:0001355)1.86492251
124Tetraplegia (HP:0002445)1.86050142
125Anomalous pulmonary venous return (HP:0010772)1.85943341
126Hypoplasia of the fovea (HP:0007750)1.85415201
127Aplasia/Hypoplasia of the fovea (HP:0008060)1.85415201
128Hemiparesis (HP:0001269)1.82168568
129Abnormality of serine family amino acid metabolism (HP:0010894)1.81998946
130Abnormality of glycine metabolism (HP:0010895)1.81998946
131Polygenic inheritance (HP:0010982)1.81841911
132Prolonged QT interval (HP:0001657)1.81684037
133Portal hypertension (HP:0001409)1.80913665
134Pointed chin (HP:0000307)1.80849555
135Onion bulb formation (HP:0003383)1.80408591
136Hyperglycinuria (HP:0003108)1.80268884
137Impaired smooth pursuit (HP:0007772)1.80232451
138Incomplete penetrance (HP:0003829)1.79051481
139Blue irides (HP:0000635)1.78560218
140Hemiplegia (HP:0002301)1.77143969
141Chromsome breakage (HP:0040012)1.76351088
142Hyperammonemia (HP:0001987)1.76137172
143Rigidity (HP:0002063)1.75893533
144Chromosomal breakage induced by crosslinking agents (HP:0003221)1.75740402
145Aplasia/Hypoplasia of the macula (HP:0008059)1.71441149
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70444197
147True hermaphroditism (HP:0010459)1.69015673
148Fused cervical vertebrae (HP:0002949)1.68267976
149Pancreatic cysts (HP:0001737)1.67526747
150Inability to walk (HP:0002540)1.67305100
151Facial diplegia (HP:0001349)1.65559856
152Absent/shortened dynein arms (HP:0200106)1.63126376
153Dynein arm defect of respiratory motile cilia (HP:0012255)1.63126376
154Abnormality of the fovea (HP:0000493)1.63027067
155Loss of speech (HP:0002371)1.62915844
156Abnormality of the pulmonary veins (HP:0011718)1.61313015
157Abnormal respiratory motile cilium physiology (HP:0012261)1.56486421
158Generalized aminoaciduria (HP:0002909)1.56483423
159Bony spicule pigmentary retinopathy (HP:0007737)1.56089465
160Tinnitus (HP:0000360)1.55902691
161Aplasia/Hypoplasia affecting the retina (HP:0008061)1.55442845
162Absent speech (HP:0001344)1.54981678
163Amaurosis fugax (HP:0100576)1.52836548
164Congenital stationary night blindness (HP:0007642)1.52248628
165Attenuation of retinal blood vessels (HP:0007843)1.51734680
166Macular degeneration (HP:0000608)1.50209536
167Ectopic kidney (HP:0000086)1.48711601
168Fasciculations (HP:0002380)1.47145790
169Pancreatic fibrosis (HP:0100732)1.46669433
170Scrotal hypoplasia (HP:0000046)1.44507287
171Hyperthyroidism (HP:0000836)1.43694111
172Gingival bleeding (HP:0000225)1.42698172
173Aplasia/Hypoplasia of the uvula (HP:0010293)1.41173290
174Increased density of long bones (HP:0006392)1.40283132
175Exotropia (HP:0000577)1.38699565
176Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.38386935
177Abnormal ciliary motility (HP:0012262)1.37559822

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.12522308
2FRK5.22694231
3MAP3K94.14686425
4NTRK33.77858170
5ACVR1B3.03909757
6KSR23.01236040
7DAPK22.99483982
8ARAF2.73617181
9BMPR1B2.46946361
10MAP3K42.40736890
11MINK12.33673529
12MAP3K132.23603046
13NTRK12.21405884
14PRKD32.18567381
15GRK12.10094606
16RIPK42.03702694
17MKNK22.02831676
18PAK61.98875031
19CAMKK11.90325674
20KSR11.84698527
21MAP2K41.83731435
22MAP2K71.79194970
23MARK11.72005848
24NTRK21.52021622
25SIK21.49893533
26TXK1.46075309
27DAPK11.45754124
28CDK51.45467969
29ADRBK21.42783455
30ZAK1.41883069
31STK381.40221684
32MAP3K21.38557574
33TAOK11.36370244
34SGK4941.31070039
35SGK2231.31070039
36PINK11.23829700
37MKNK11.23731991
38FES1.23335154
39MAP3K121.22147347
40RAF11.21038978
41PRPF4B1.16325318
42RPS6KB21.15858105
43BMPR21.14449788
44OXSR11.10625951
45CAMKK21.06869541
46TGFBR11.06204114
47TYRO31.03354609
48SGK21.03219233
49GRK50.99650241
50PRKCG0.97877586
51WNK30.95980169
52STK30.94939715
53RET0.92726637
54SGK30.91204092
55PLK40.90055319
56INSRR0.88759237
57PRKCH0.87967516
58MAPK130.86858558
59BCR0.86805155
60BRAF0.85948227
61TAF10.84749853
62NEK10.83875159
63WNK40.82724090
64MAP3K10.82560977
65PDPK10.82540906
66TNIK0.79524616
67LATS20.76633429
68CDK180.76374772
69CAMK2A0.76138974
70MAP2K10.73870600
71CDK150.73401244
72STK110.73331467
73PHKG20.73240166
74PHKG10.73240166
75PTK2B0.72850250
76STK38L0.72453319
77CDK140.71947024
78PDK10.71637865
79LMTK20.71422425
80UHMK10.71125913
81SGK10.70705687
82TNK20.67378710
83PRKCZ0.66773095
84CAMK2B0.65671279
85RIPK10.65572358
86PBK0.64369958
87MOS0.63823699
88PLK20.62474971
89CAMK10.62146087
90CDK11A0.60687883
91OBSCN0.60638113
92CHEK20.60286142
93PAK30.59620927
94MARK20.59122566
95SIK30.54853374
96CSNK1G20.53175566
97CAMK2G0.51331922
98MATK0.50680474
99MAPKAPK50.50115875
100VRK20.48828557
101CAMK40.47918925
102ADRBK10.47142496
103MAP3K70.46856526
104RPS6KA30.46488824
105DAPK30.44371364
106CHEK10.44120658
107CDK190.43565010
108CASK0.43483639
109DYRK20.41844081
110JAK20.41692465
111CDK40.40790393
112CCNB10.39974967
113FER0.39279100
114PRKAA20.37626724
115FYN0.36949690
116TIE10.36192249
117NEK60.36038856
118PRKD20.35508951
119FGFR20.35044532
120ALK0.34255506
121WNK10.34108661
122STK390.34030563
123DYRK1A0.33860286
124MAPK100.33760629
125PRKACG0.33496907
126BCKDK0.33369048
127PRKCE0.32815208
128PRKG10.32294673
129NUAK10.31220691
130PRKCB0.29949937
131PNCK0.29776772
132MAP3K60.29727623
133CAMK2D0.29695351
134TTK0.28564413
135MAP4K20.28556141
136MAPK70.27390041
137PKN10.27252085
138CSNK1G10.26789235
139VRK10.26061400
140RPS6KB10.24161813
141MTOR0.23322413
142AURKA0.22944610
143TAOK30.22075007
144ERBB20.19802314
145GRK70.18777089
146PDGFRA0.18121222
147PRKACA0.16909885
148ERBB40.14920703
149CSNK1A10.14535876
150PRKAA10.14310980
151CSNK1G30.12870507
152PRKCA0.11992105
153PRKACB0.10476471
154CDK90.10056148
155MELK0.09481592
156CSNK1D0.09026445
157CSNK1A1L0.08637568

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.41709939
2Nitrogen metabolism_Homo sapiens_hsa009103.23599354
3Olfactory transduction_Homo sapiens_hsa047403.17663044
4Synaptic vesicle cycle_Homo sapiens_hsa047212.61821043
5Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.40026578
6Nicotine addiction_Homo sapiens_hsa050332.38360897
7RNA polymerase_Homo sapiens_hsa030202.36486421
8Caffeine metabolism_Homo sapiens_hsa002322.28317779
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.27925256
10GABAergic synapse_Homo sapiens_hsa047272.27763171
11Fatty acid biosynthesis_Homo sapiens_hsa000612.20994013
12Morphine addiction_Homo sapiens_hsa050322.14040340
13Circadian entrainment_Homo sapiens_hsa047132.13630859
14Primary bile acid biosynthesis_Homo sapiens_hsa001202.06491168
15Amphetamine addiction_Homo sapiens_hsa050312.05010138
16Retinol metabolism_Homo sapiens_hsa008302.04797425
17Glutamatergic synapse_Homo sapiens_hsa047241.99834304
18Long-term potentiation_Homo sapiens_hsa047201.97069723
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.94327803
20Arginine biosynthesis_Homo sapiens_hsa002201.89909655
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87010068
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.85197672
23Dopaminergic synapse_Homo sapiens_hsa047281.84481453
24Cocaine addiction_Homo sapiens_hsa050301.79702144
25Ether lipid metabolism_Homo sapiens_hsa005651.74691588
26Salivary secretion_Homo sapiens_hsa049701.68491384
27Cholinergic synapse_Homo sapiens_hsa047251.62351160
28Butanoate metabolism_Homo sapiens_hsa006501.59498489
29Bile secretion_Homo sapiens_hsa049761.53182196
30Insulin secretion_Homo sapiens_hsa049111.53170089
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48929285
32Gastric acid secretion_Homo sapiens_hsa049711.48793767
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46715339
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45929337
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.44570493
36Renin secretion_Homo sapiens_hsa049241.42511962
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33709185
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31006083
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.26754469
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.25901893
41Oxytocin signaling pathway_Homo sapiens_hsa049211.23162441
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21002096
43Taste transduction_Homo sapiens_hsa047421.20775066
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20330499
45Serotonergic synapse_Homo sapiens_hsa047261.19028709
46Calcium signaling pathway_Homo sapiens_hsa040201.17284168
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13375386
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12870441
49Gap junction_Homo sapiens_hsa045401.10066921
50GnRH signaling pathway_Homo sapiens_hsa049121.09428444
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06112254
52Collecting duct acid secretion_Homo sapiens_hsa049661.04633881
53Purine metabolism_Homo sapiens_hsa002301.01214759
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01078974
55Renin-angiotensin system_Homo sapiens_hsa046141.00839802
56Long-term depression_Homo sapiens_hsa047301.00630735
57cAMP signaling pathway_Homo sapiens_hsa040240.97602264
58Linoleic acid metabolism_Homo sapiens_hsa005910.97065737
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93933850
60Tryptophan metabolism_Homo sapiens_hsa003800.93340014
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91335648
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.86574598
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86013788
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83209773
65Glioma_Homo sapiens_hsa052140.79395010
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78769399
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74396540
68Propanoate metabolism_Homo sapiens_hsa006400.73769686
69Thyroid hormone synthesis_Homo sapiens_hsa049180.73532612
70Type II diabetes mellitus_Homo sapiens_hsa049300.73296823
71Estrogen signaling pathway_Homo sapiens_hsa049150.72584405
72Homologous recombination_Homo sapiens_hsa034400.72061935
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69123127
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68995717
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68840398
76PPAR signaling pathway_Homo sapiens_hsa033200.68470564
77Circadian rhythm_Homo sapiens_hsa047100.67998812
78beta-Alanine metabolism_Homo sapiens_hsa004100.67958750
79Fatty acid degradation_Homo sapiens_hsa000710.67634846
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66792338
81Melanogenesis_Homo sapiens_hsa049160.66742894
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66585933
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.65973915
84N-Glycan biosynthesis_Homo sapiens_hsa005100.65389516
85ABC transporters_Homo sapiens_hsa020100.64838489
86Basal cell carcinoma_Homo sapiens_hsa052170.64121722
87Pyrimidine metabolism_Homo sapiens_hsa002400.63011425
88Pyruvate metabolism_Homo sapiens_hsa006200.62074027
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.61727186
90Pancreatic secretion_Homo sapiens_hsa049720.61472800
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60978312
92Phenylalanine metabolism_Homo sapiens_hsa003600.59973141
93ErbB signaling pathway_Homo sapiens_hsa040120.59636841
94Glucagon signaling pathway_Homo sapiens_hsa049220.58971181
95Hedgehog signaling pathway_Homo sapiens_hsa043400.57348940
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.56953842
97Peroxisome_Homo sapiens_hsa041460.56032994
98Cardiac muscle contraction_Homo sapiens_hsa042600.55764376
99Complement and coagulation cascades_Homo sapiens_hsa046100.55226179
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.54617571
101Prion diseases_Homo sapiens_hsa050200.54392786
102Dorso-ventral axis formation_Homo sapiens_hsa043200.52983350
103Non-homologous end-joining_Homo sapiens_hsa034500.52865759
104Axon guidance_Homo sapiens_hsa043600.51083880
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50594103
106Melanoma_Homo sapiens_hsa052180.50340318
107Phototransduction_Homo sapiens_hsa047440.49774860
108Starch and sucrose metabolism_Homo sapiens_hsa005000.47970392
109Glycerolipid metabolism_Homo sapiens_hsa005610.47830569
110Histidine metabolism_Homo sapiens_hsa003400.46049575
111Fatty acid metabolism_Homo sapiens_hsa012120.45943444
112Biosynthesis of amino acids_Homo sapiens_hsa012300.44780555
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44382898
114Oocyte meiosis_Homo sapiens_hsa041140.43962514
115Choline metabolism in cancer_Homo sapiens_hsa052310.42364361
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41699861
117Fanconi anemia pathway_Homo sapiens_hsa034600.40884568
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39206367
119Chemical carcinogenesis_Homo sapiens_hsa052040.38814752
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38447915
121Vibrio cholerae infection_Homo sapiens_hsa051100.38348945
122Non-small cell lung cancer_Homo sapiens_hsa052230.38197543
123Tyrosine metabolism_Homo sapiens_hsa003500.36688242
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35844741
125Ovarian steroidogenesis_Homo sapiens_hsa049130.35142747
126Alcoholism_Homo sapiens_hsa050340.34876732
127Rap1 signaling pathway_Homo sapiens_hsa040150.34238104
128Insulin signaling pathway_Homo sapiens_hsa049100.34209911
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.34163328
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.34022938
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33974374
132Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33607124
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32827671
134African trypanosomiasis_Homo sapiens_hsa051430.32825082
135Glutathione metabolism_Homo sapiens_hsa004800.28480777
136Metabolic pathways_Homo sapiens_hsa011000.28247498
137Hippo signaling pathway_Homo sapiens_hsa043900.28243535
138Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28046281
139Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26854007
140Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26798388
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26691479
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25018248
143MAPK signaling pathway_Homo sapiens_hsa040100.23881388
144Ras signaling pathway_Homo sapiens_hsa040140.21722576

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