DCDC2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)9.31607555
2regulation of cilium movement (GO:0003352)7.88016343
3primary alcohol catabolic process (GO:0034310)7.32503663
4vitamin transmembrane transport (GO:0035461)6.88436806
5left/right axis specification (GO:0070986)6.88146517
6ventricular system development (GO:0021591)6.86194214
7microtubule bundle formation (GO:0001578)6.44325450
8ethanol metabolic process (GO:0006067)6.16581841
9intraciliary transport (GO:0042073)6.00468528
10cilium organization (GO:0044782)5.85428919
11tolerance induction (GO:0002507)5.77815367
12diterpenoid biosynthetic process (GO:0016102)5.72570540
13cilium assembly (GO:0042384)5.69138408
14response to xenobiotic stimulus (GO:0009410)5.50401404
15neurotransmitter-gated ion channel clustering (GO:0072578)5.31986803
16lung epithelium development (GO:0060428)5.23467007
17pyrimidine-containing compound transmembrane transport (GO:0072531)5.12297637
18one-carbon compound transport (GO:0019755)5.05285007
19centriole assembly (GO:0098534)5.02334346
20synaptic vesicle docking involved in exocytosis (GO:0016081)4.97791910
21positive regulation of cellular amide metabolic process (GO:0034250)4.90122280
22establishment of apical/basal cell polarity (GO:0035089)4.84716911
23regulation of interleukin-5 production (GO:0032674)4.78969296
24protein localization to cilium (GO:0061512)4.78562536
25glomerular epithelial cell development (GO:0072310)4.75958041
26negative regulation of T cell differentiation in thymus (GO:0033085)4.69552312
27microtubule-based movement (GO:0007018)4.61333609
28regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.60841513
29regulation of germinal center formation (GO:0002634)4.57096393
30regulation of microtubule-based movement (GO:0060632)4.56697305
31sperm capacitation (GO:0048240)4.55739537
32locomotory exploration behavior (GO:0035641)4.55202083
33regulation of interleukin-13 production (GO:0032656)4.51486098
34negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.50590958
35cellular component assembly involved in morphogenesis (GO:0010927)4.48585017
36long-term synaptic potentiation (GO:0060291)4.43425862
37ethanol oxidation (GO:0006069)4.42681065
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.38820617
39presynaptic membrane assembly (GO:0097105)4.34653919
40regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.32286251
41glucose 6-phosphate metabolic process (GO:0051156)4.30756836
42positive regulation of tolerance induction (GO:0002645)4.27174557
43negative regulation of neurotransmitter secretion (GO:0046929)4.22399523
44cell projection assembly (GO:0030031)4.15770457
45cilium morphogenesis (GO:0060271)4.15330355
46establishment or maintenance of monopolar cell polarity (GO:0061339)4.14838310
47establishment of monopolar cell polarity (GO:0061162)4.14838310
48mechanosensory behavior (GO:0007638)4.08660549
49regulation of beta-amyloid formation (GO:1902003)4.06715050
50ionotropic glutamate receptor signaling pathway (GO:0035235)4.06416170
51regulation of short-term neuronal synaptic plasticity (GO:0048172)4.01600265
52terpenoid biosynthetic process (GO:0016114)3.95769417
53neuron cell-cell adhesion (GO:0007158)3.90817123
54cytoplasmic microtubule organization (GO:0031122)3.88509133
55vocalization behavior (GO:0071625)3.88222250
56negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.87580289
57microtubule depolymerization (GO:0007019)3.86790118
58negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.85065910
59retinoic acid metabolic process (GO:0042573)3.82851833
60regulation of glutamate receptor signaling pathway (GO:1900449)3.81949419
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.81236111
62positive regulation of cardiac muscle cell differentiation (GO:2000727)3.80168581
63positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.79304727
64synaptic vesicle maturation (GO:0016188)3.76917356
65negative regulation of dendrite morphogenesis (GO:0050774)3.76055981
66nucleoside diphosphate phosphorylation (GO:0006165)3.75283943
67negative regulation of inclusion body assembly (GO:0090084)3.74583063
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.74154477
69cerebellar granule cell differentiation (GO:0021707)3.73310404
70glutamate secretion (GO:0014047)3.72911989
71presynaptic membrane organization (GO:0097090)3.71426378
72exploration behavior (GO:0035640)3.68248337
73exogenous drug catabolic process (GO:0042738)3.56771728
74microtubule polymerization or depolymerization (GO:0031109)3.54810186
75positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.54263671
76glutamate receptor signaling pathway (GO:0007215)3.54149697
77membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50073888
78positive regulation of synapse maturation (GO:0090129)3.49861644
79lateral ventricle development (GO:0021670)3.49776645
80establishment of planar polarity (GO:0001736)3.47500062
81establishment of tissue polarity (GO:0007164)3.47500062
82regulation of amyloid precursor protein catabolic process (GO:1902991)3.47032701
83regulation of synaptic vesicle exocytosis (GO:2000300)3.46860138
84negative regulation of neurotransmitter transport (GO:0051589)3.43688001
85negative regulation of synaptic transmission, GABAergic (GO:0032229)3.40014157
86neuron-neuron synaptic transmission (GO:0007270)3.39044058
87epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.32578117
88postsynaptic membrane organization (GO:0001941)3.28431676
89cilium or flagellum-dependent cell motility (GO:0001539)3.27424027
90ether lipid metabolic process (GO:0046485)3.21824712
91regulation of tolerance induction (GO:0002643)3.21581491
92protein localization to synapse (GO:0035418)3.21574628
93epithelial cilium movement (GO:0003351)3.21216176
94synaptic transmission, glutamatergic (GO:0035249)3.20369831
95O-glycan processing (GO:0016266)3.17852361
96negative regulation of dendrite development (GO:2000171)3.16865252
97embryonic viscerocranium morphogenesis (GO:0048703)3.16847524
98primary alcohol metabolic process (GO:0034308)3.15925433
99C4-dicarboxylate transport (GO:0015740)3.14175997
100G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.13987825
101cerebellar Purkinje cell differentiation (GO:0021702)3.12170263
102positive regulation of smoothened signaling pathway (GO:0045880)3.10884490
103negative regulation of synaptic transmission (GO:0050805)3.10058126
104long term synaptic depression (GO:0060292)3.09097000
105negative regulation of protein oligomerization (GO:0032460)3.07191535
106hydrogen peroxide biosynthetic process (GO:0050665)3.06831004
107regulation of synapse structural plasticity (GO:0051823)3.03096166
108glutathione derivative biosynthetic process (GO:1901687)3.01641937
109glutathione derivative metabolic process (GO:1901685)3.01641937
110auditory behavior (GO:0031223)3.00674651
111regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.00525521
112regulation of microtubule depolymerization (GO:0031114)3.00205892
113gamma-aminobutyric acid signaling pathway (GO:0007214)3.00161403
114axonemal dynein complex assembly (GO:0070286)21.9676278
115retinol metabolic process (GO:0042572)2.99755340
116regulation of synaptic vesicle transport (GO:1902803)2.99456212
117regulation of synaptic plasticity (GO:0048167)2.98880499
118multicellular organismal water homeostasis (GO:0050891)2.97871447
119neurotransmitter secretion (GO:0007269)2.97587064
120neuronal action potential propagation (GO:0019227)2.95160471
121megakaryocyte development (GO:0035855)2.94314619
122cilium movement (GO:0003341)2.92996104
123negative regulation of immunoglobulin mediated immune response (GO:0002890)2.90850691
124negative regulation of B cell mediated immunity (GO:0002713)2.90850691
125negative regulation of complement activation (GO:0045916)2.90076246
126regulation of cellular amide metabolic process (GO:0034248)2.86584214
127regulation of neuronal synaptic plasticity (GO:0048168)2.84487471
128sperm motility (GO:0030317)2.84252378
129synaptic vesicle exocytosis (GO:0016079)2.81530180
130aldehyde catabolic process (GO:0046185)2.79243137
131response to auditory stimulus (GO:0010996)2.78532680
132regulation of excitatory postsynaptic membrane potential (GO:0060079)2.78079687
133L-amino acid import (GO:0043092)2.76997293
134phosphatidylcholine biosynthetic process (GO:0006656)2.76172154
135drug catabolic process (GO:0042737)2.75949729
136carnitine metabolic process (GO:0009437)2.75690026
137hypotonic response (GO:0006971)2.75633198
138transmission of nerve impulse (GO:0019226)2.74854125
139positive regulation of catecholamine secretion (GO:0033605)2.74124069
140determination of left/right symmetry (GO:0007368)2.73576200
141microtubule-based process (GO:0007017)2.73369111
142dendritic spine morphogenesis (GO:0060997)2.73249047
143regulation of long-term neuronal synaptic plasticity (GO:0048169)2.71238925
144reactive oxygen species biosynthetic process (GO:1903409)2.70661647
145positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.70162197
146oligosaccharide biosynthetic process (GO:0009312)2.69822023
147phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.69515098
148sequestering of extracellular ligand from receptor (GO:0035581)2.68954307
149regulation of female receptivity (GO:0045924)2.68879916
150retinal cone cell development (GO:0046549)2.67962572
151regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.67504944
152L-fucose catabolic process (GO:0042355)2.66993784
153fucose catabolic process (GO:0019317)2.66993784
154L-fucose metabolic process (GO:0042354)2.66993784
155regulation of postsynaptic membrane potential (GO:0060078)2.66483259
156retinal rod cell development (GO:0046548)2.64160440
157response to histamine (GO:0034776)2.64128813
158serotonin metabolic process (GO:0042428)2.64104571
159antigen processing and presentation via MHC class Ib (GO:0002475)2.63846797
160neuromuscular process controlling posture (GO:0050884)2.63763433
161associative learning (GO:0008306)2.62573683
162determination of bilateral symmetry (GO:0009855)2.62309224
163lateral sprouting from an epithelium (GO:0060601)2.61489676
164positive regulation of synaptic transmission (GO:0050806)2.60753279
165regulation of response to osmotic stress (GO:0047484)2.60715558
166learning (GO:0007612)2.59858988
167excretion (GO:0007588)2.58089927
168regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.57678665
169specification of symmetry (GO:0009799)2.56311063
170mast cell degranulation (GO:0043303)2.55865249
171mast cell activation involved in immune response (GO:0002279)2.55865249
172fucosylation (GO:0036065)2.55578750
173negative regulation of humoral immune response (GO:0002921)2.55466382
174behavioral defense response (GO:0002209)2.55370847
175behavioral fear response (GO:0001662)2.55370847
176iron ion import (GO:0097286)2.54790318
177apical protein localization (GO:0045176)2.54786273
178organelle assembly (GO:0070925)2.52625773
179positive regulation of protein homodimerization activity (GO:0090073)2.52552340
180progesterone metabolic process (GO:0042448)2.51716800
181water homeostasis (GO:0030104)2.51638646
182calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.49510326
183regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.48773127
184dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.48442317
185smoothened signaling pathway (GO:0007224)2.48313127
186hydrogen peroxide catabolic process (GO:0042744)2.48205006
187regulation of autophagic vacuole assembly (GO:2000785)2.48102480
188negative regulation of microtubule depolymerization (GO:0007026)2.42869184
189regulation of apoptotic cell clearance (GO:2000425)2.40319075
190carnitine transmembrane transport (GO:1902603)2.40152286
191motile cilium assembly (GO:0044458)15.0789221
192axoneme assembly (GO:0035082)10.1108999

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.45104443
2EZH2_22144423_ChIP-Seq_EOC_Human4.35779480
3GBX2_23144817_ChIP-Seq_PC3_Human3.77630964
4FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.33444303
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.12756022
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.90430506
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.75541605
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68560201
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.54251639
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.53574324
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.47225003
12TAF15_26573619_Chip-Seq_HEK293_Human2.45694109
13DROSHA_22980978_ChIP-Seq_HELA_Human2.28000269
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.25492973
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.25209558
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.22844875
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21917239
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16753466
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16213412
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.15612388
21SMC4_20622854_ChIP-Seq_HELA_Human2.12642801
22ESR2_21235772_ChIP-Seq_MCF-7_Human2.11745535
23REST_21632747_ChIP-Seq_MESCs_Mouse2.10520692
24RUNX1_27514584_Chip-Seq_MCF-7_Human2.09061916
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.07514675
26JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05385641
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.04861426
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03228443
29EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02117763
30RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02117763
31MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00828563
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99811826
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98786006
34ZNF274_21170338_ChIP-Seq_K562_Hela1.97458606
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.95228653
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93445187
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.91978853
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91307220
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.88731129
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.84508487
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.82997166
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.82004785
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.81002850
44FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.74752457
45P300_19829295_ChIP-Seq_ESCs_Human1.72210016
46STAT1_20625510_ChIP-Seq_HELA_Human1.71980483
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.71928574
48AHR_22903824_ChIP-Seq_MCF-7_Human1.70934135
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.70046706
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69042544
51TP63_22573176_ChIP-Seq_HFKS_Human1.67979960
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.67693466
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65308487
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64820017
55SMAD4_21799915_ChIP-Seq_A2780_Human1.63884922
56P63_26484246_Chip-Seq_KERATINOCYTES_Human1.63879745
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.62528268
58KLF5_25053715_ChIP-Seq_YYC3_Human1.61370030
59P68_20966046_ChIP-Seq_HELA_Human1.60489013
60PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.55520705
61FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.54365926
62AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.54185140
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53037954
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.51653002
65AR_25329375_ChIP-Seq_VCAP_Human1.51525930
66SOX9_24532713_ChIP-Seq_HFSC_Mouse1.50554180
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50202849
68TP63_23658742_ChIP-Seq_EP156T_Human1.49905257
69CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.49821648
70ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49757898
71* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.48841462
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48024291
73RACK7_27058665_Chip-Seq_MCF-7_Human1.45673959
74GATA1_19941826_ChIP-Seq_K562_Human1.44606371
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43050480
76RAD21_21589869_ChIP-Seq_MESCs_Mouse1.42445642
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41464098
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.41307647
79CREB1_26743006_Chip-Seq_LNCaP_Human1.40804042
80TDRD3_21172665_ChIP-Seq_MCF-7_Human1.40178925
81CTNNB1_20460455_ChIP-Seq_HCT116_Human1.39869354
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.38654108
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.38635774
84PHF8_20622854_ChIP-Seq_HELA_Human1.38146286
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34245339
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32556931
87CTCF_20526341_ChIP-Seq_ESCs_Human1.32496047
88FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31474583
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31089221
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30998722
91* CTCF_27219007_Chip-Seq_Bcells_Human1.29822400
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.29284689
93LXR_22292898_ChIP-Seq_THP-1_Human1.29068579
94YY1_22570637_ChIP-Seq_MALME-3M_Human1.29008519
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27850644
96FOXA1_25552417_ChIP-Seq_VCAP_Human1.26253162
97RUNX_20019798_ChIP-Seq_JUKART_Human1.24584510
98SOX2_20726797_ChIP-Seq_SW620_Human1.23570114
99GATA2_21666600_ChIP-Seq_HMVEC_Human1.22965187
100AR_21572438_ChIP-Seq_LNCaP_Human1.21578968
101ETV1_20927104_ChIP-Seq_GIST48_Human1.20973820
102CDX2_20551321_ChIP-Seq_CACO-2_Human1.20898068
103EWS_26573619_Chip-Seq_HEK293_Human1.20616246
104SMRT_27268052_Chip-Seq_Bcells_Human1.20099043
105CBX2_27304074_Chip-Seq_ESCs_Mouse1.19510037
106ERG_21242973_ChIP-ChIP_JURKAT_Human1.19197770
107STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18677740
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18522031
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18353127
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17104439
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17104439
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15941760
113SOX2_21211035_ChIP-Seq_LN229_Gbm1.15318854
114E2F1_20622854_ChIP-Seq_HELA_Human1.14731630
115BCOR_27268052_Chip-Seq_Bcells_Human1.13550675
116TP53_18474530_ChIP-ChIP_U2OS_Human1.12278873
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11952528
118NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11952528
119P300_27268052_Chip-Seq_Bcells_Human1.11824417
120NANOG_18555785_Chip-Seq_ESCs_Mouse1.11466857
121FUS_26573619_Chip-Seq_HEK293_Human1.10240044
122SCL_19346495_ChIP-Seq_HPC-7_Human1.10086505
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.09526378
124FOXO3_23340844_ChIP-Seq_DLD1_Human1.09500595
125DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09158410
126NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09134246
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08165094
128FOXA2_19822575_ChIP-Seq_HepG2_Human1.06141790
129STAT3_23295773_ChIP-Seq_U87_Human1.05334037
130PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04270565
131SA1_27219007_Chip-Seq_ERYTHROID_Human1.03437308
132* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02409108
133GATA3_24758297_ChIP-Seq_MCF-7_Human1.02207575
134IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01015772
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00788241
136* HNFA_21074721_ChIP-Seq_CACO-2_Human1.00777719
137* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.00077533
138* PHF8_20622853_ChIP-Seq_HELA_Human0.99749009
139GATA4_25053715_ChIP-Seq_YYC3_Human0.98858112
140RXR_22108803_ChIP-Seq_LS180_Human0.98255097
141FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.97291933
142LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96693437
143PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96319304
144SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96123027
145BCL6_27268052_Chip-Seq_Bcells_Human0.95723281
146SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94633415
147GATA6_21074721_ChIP-Seq_CACO-2_Human0.94543983
148FLI1_21867929_ChIP-Seq_CD8_Mouse0.93765265
149TCF4_23295773_ChIP-Seq_U87_Human0.93080798
150SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92788734
151CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92429309
152RUNX2_22187159_ChIP-Seq_PCA_Human0.92211479
153* RBPJ_21746931_ChIP-Seq_IB4_Human0.92047980
154MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91939509
155FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91904224
156HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91725133
157VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91724158
158VDR_22108803_ChIP-Seq_LS180_Human0.91192921
159RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90934459
160TP53_22127205_ChIP-Seq_IMR90_Human0.90236925
161NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90017490
162SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89946338
163WDR5_24793694_ChIP-Seq_LNCAP_Human0.89593001
164SOX2_21211035_ChIP-Seq_LN229_Human0.89577170
165ER_23166858_ChIP-Seq_MCF-7_Human0.89185928
166GATA2_19941826_ChIP-Seq_K562_Human0.88480365
167CEBPB_22108803_ChIP-Seq_LS180_Human0.88017918
168CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88005676
169WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87441255
170ZNF263_19887448_ChIP-Seq_K562_Human0.87389272
171AR_19668381_ChIP-Seq_PC3_Human0.87360792
172* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.87120288
173IRF1_19129219_ChIP-ChIP_H3396_Human0.86858593
174TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86773821
175SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86761230
176P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.86681008
177EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86341385
178CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86171995
179VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85946324
180RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.85839418
181GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85308839
182P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84729408
183RNF2_27304074_Chip-Seq_NSC_Mouse0.82256968
184SMAD3_21741376_ChIP-Seq_ESCs_Human0.81900210
185SMAD4_21741376_ChIP-Seq_HESCs_Human0.81881350
186BMI1_23680149_ChIP-Seq_NPCS_Mouse0.81080289
187CBP_20019798_ChIP-Seq_JUKART_Human0.80526089
188IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80526089
189P53_22387025_ChIP-Seq_ESCs_Mouse0.80281854

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology6.43354452
2MP0004859_abnormal_synaptic_plasticity4.86747996
3MP0004043_abnormal_pH_regulation4.30314235
4MP0003880_abnormal_central_pattern4.27347178
5MP0001984_abnormal_olfaction3.73432987
6MP0005623_abnormal_meninges_morphology3.63756327
7MP0009745_abnormal_behavioral_response3.58086120
8MP0003635_abnormal_synaptic_transmissio3.43658372
9MP0004133_heterotaxia3.35684476
10MP0002064_seizures3.27295280
11MP0002063_abnormal_learning/memory/cond2.93587956
12MP0002822_catalepsy2.88482084
13MP0008789_abnormal_olfactory_epithelium2.77295438
14MP0002736_abnormal_nociception_after2.72145076
15MP0001968_abnormal_touch/_nociception2.62222294
16MP0002572_abnormal_emotion/affect_behav2.62123647
17MP0001501_abnormal_sleep_pattern2.56976320
18MP0009046_muscle_twitch2.52264970
19MP0003183_abnormal_peptide_metabolism2.39698448
20MP0002272_abnormal_nervous_system2.38652802
21MP0005646_abnormal_pituitary_gland2.37461536
22MP0002876_abnormal_thyroid_physiology2.36836962
23MP0001188_hyperpigmentation2.34520778
24MP0000383_abnormal_hair_follicle2.28940392
25MP0005377_hearing/vestibular/ear_phenot2.22725780
26MP0003878_abnormal_ear_physiology2.22725780
27MP0003656_abnormal_erythrocyte_physiolo2.20096592
28MP0005083_abnormal_biliary_tract2.18126578
29MP0000566_synostosis2.13777913
30MP0002168_other_aberrant_phenotype2.12193507
31MP0002282_abnormal_trachea_morphology2.05847957
32MP0002067_abnormal_sensory_capabilities1.98839827
33MP0002735_abnormal_chemical_nociception1.95793903
34MP0001765_abnormal_ion_homeostasis1.95413273
35MP0010678_abnormal_skin_adnexa1.93860376
36MP0003879_abnormal_hair_cell1.91256145
37MP0003329_amyloid_beta_deposits1.88318571
38MP0004019_abnormal_vitamin_homeostasis1.85104727
39MP0001346_abnormal_lacrimal_gland1.81474647
40MP0008569_lethality_at_weaning1.80442123
41MP0003633_abnormal_nervous_system1.77822116
42MP0005394_taste/olfaction_phenotype1.74856741
43MP0005499_abnormal_olfactory_system1.74856741
44MP0003075_altered_response_to1.74409015
45MP0005409_darkened_coat_color1.70718849
46MP0002277_abnormal_respiratory_mucosa1.68740517
47MP0001486_abnormal_startle_reflex1.63470851
48MP0002160_abnormal_reproductive_system1.62671643
49MP0004270_analgesia1.60807872
50MP0002132_abnormal_respiratory_system1.60184370
51MP0002557_abnormal_social/conspecific_i1.59904311
52MP0002734_abnormal_mechanical_nocicepti1.59474138
53MP0003690_abnormal_glial_cell1.55900256
54MP0003631_nervous_system_phenotype1.51405634
55MP0004858_abnormal_nervous_system1.46693731
56MP0003122_maternal_imprinting1.44158836
57MP0001440_abnormal_grooming_behavior1.42511779
58MP0002909_abnormal_adrenal_gland1.41443313
59MP0010155_abnormal_intestine_physiology1.39583709
60MP0009780_abnormal_chondrocyte_physiolo1.38712934
61MP0000681_abnormal_thyroid_gland1.38345508
62MP0009379_abnormal_foot_pigmentation1.36409440
63MP0004510_myositis1.32717320
64MP0005395_other_phenotype1.32272095
65MP0003632_abnormal_nervous_system1.31154231
66MP0004782_abnormal_surfactant_physiolog1.31119508
67MP0003943_abnormal_hepatobiliary_system1.28503244
68MP0003045_fibrosis1.28045042
69MP0005248_abnormal_Harderian_gland1.27852330
70MP0005165_increased_susceptibility_to1.27758858
71MP0001849_ear_inflammation1.25882144
72MP0005503_abnormal_tendon_morphology1.24397100
73MP0003303_peritoneal_inflammation1.21204367
74MP0004147_increased_porphyrin_level1.19401166
75MP0000015_abnormal_ear_pigmentation1.19342504
76MP0002733_abnormal_thermal_nociception1.15934362
77MP0005636_abnormal_mineral_homeostasis1.15554427
78MP0000604_amyloidosis1.13560363
79MP0001970_abnormal_pain_threshold1.12793734
80MP0010234_abnormal_vibrissa_follicle1.12264785
81MP0006292_abnormal_olfactory_placode1.07632197
82MP0001502_abnormal_circadian_rhythm1.06509785
83MP0003453_abnormal_keratinocyte_physiol1.06329135
84MP0005164_abnormal_response_to1.05558313
85MP0002066_abnormal_motor_capabilities/c1.05179865
86MP0001905_abnormal_dopamine_level1.04063045
87MP0004142_abnormal_muscle_tone1.02295548
88MP0010368_abnormal_lymphatic_system1.01449641
89MP0000372_irregular_coat_pigmentation1.01442157
90MP0005310_abnormal_salivary_gland1.00119703
91MP0003136_yellow_coat_color0.99852507
92MP0010030_abnormal_orbit_morphology0.99077825
93MP0001851_eye_inflammation0.98589326
94MP0006082_CNS_inflammation0.97597134
95MP0000678_abnormal_parathyroid_gland0.97534447
96MP0001545_abnormal_hematopoietic_system0.96508828
97MP0005397_hematopoietic_system_phenotyp0.96508828
98MP0005410_abnormal_fertilization0.95438616
99MP0009643_abnormal_urine_homeostasis0.94604712
100MP0005166_decreased_susceptibility_to0.94437061
101MP0002090_abnormal_vision0.93809442
102MP0008875_abnormal_xenobiotic_pharmacok0.93558460
103MP0009697_abnormal_copulation0.92909417
104MP0002136_abnormal_kidney_physiology0.92263006
105MP0004811_abnormal_neuron_physiology0.90527117
106MP0002405_respiratory_system_inflammati0.89935001
107MP0003866_abnormal_defecation0.87041179
108MP0000920_abnormal_myelination0.87027117
109MP0002184_abnormal_innervation0.86378516
110MP0008260_abnormal_autophagy0.85857767
111MP0002638_abnormal_pupillary_reflex0.85792920
112MP0004484_altered_response_of0.85280530
113MP0005387_immune_system_phenotype0.84039957
114MP0001790_abnormal_immune_system0.84039957
115MP0001177_atelectasis0.82060761
116MP0004808_abnormal_hematopoietic_stem0.81538623
117MP0006276_abnormal_autonomic_nervous0.80992067
118MP0005058_abnormal_lysosome_morphology0.80307336
119MP0002233_abnormal_nose_morphology0.79894171
120MP0003787_abnormal_imprinting0.79843165
121MP0002882_abnormal_neuron_morphology0.78463516
122MP0005386_behavior/neurological_phenoty0.77921314
123MP0004924_abnormal_behavior0.77921314
124MP0004264_abnormal_extraembryonic_tissu0.76938702
125MP0005671_abnormal_response_to0.75125244
126MP0001963_abnormal_hearing_physiology0.74635831
127MP0002249_abnormal_larynx_morphology0.74576144
128MP0001879_abnormal_lymphatic_vessel0.74029955
129MP0005365_abnormal_bile_salt0.73627767
130MP0004130_abnormal_muscle_cell0.73300176
131MP0000858_altered_metastatic_potential0.73172737
132MP0003172_abnormal_lysosome_physiology0.71802119
133MP0001835_abnormal_antigen_presentation0.71278422
134MP0001873_stomach_inflammation0.71218247
135MP0002234_abnormal_pharynx_morphology0.70706123
136MP0005220_abnormal_exocrine_pancreas0.69739842
137MP0000685_abnormal_immune_system0.69264541
138MP0000465_gastrointestinal_hemorrhage0.69134483
139MP0005389_reproductive_system_phenotype0.68481185
140MP0008872_abnormal_physiological_respon0.67966211
141MP0003698_abnormal_male_reproductive0.67660008
142MP0005023_abnormal_wound_healing0.67420941
143MP0002098_abnormal_vibrissa_morphology0.66970936
144MP0001929_abnormal_gametogenesis0.66795363
145MP0004085_abnormal_heartbeat0.65768298
146MP0000955_abnormal_spinal_cord0.64470353
147MP0001270_distended_abdomen0.63011867
148MP0005408_hypopigmentation0.62986594
149MP0004883_abnormal_blood_vessel0.62787981
150MP0003638_abnormal_response/metabolism_0.62272867
151MP0001666_abnormal_nutrient_absorption0.62089772
152MP0002229_neurodegeneration0.61856583
153MP0002896_abnormal_bone_mineralization0.57199210
154MP0001485_abnormal_pinna_reflex0.56798705
155MP0009763_increased_sensitivity_to0.56642689
156MP0009765_abnormal_xenobiotic_induced0.54709587
157MP0001664_abnormal_digestion0.54492165
158MP0000467_abnormal_esophagus_morphology0.54338233
159MP0002116_abnormal_craniofacial_bone0.53070607
160MP0001324_abnormal_eye_pigmentation0.52899135
161MP0005085_abnormal_gallbladder_physiolo0.50347366
162MP0000026_abnormal_inner_ear0.49115661
163MP0009703_decreased_birth_body0.46065761
164MP0002133_abnormal_respiratory_system0.44998992
165MP0005388_respiratory_system_phenotype0.44998992
166MP0002135_abnormal_kidney_morphology0.43935017
167MP0001663_abnormal_digestive_system0.41938960
168MP0009384_cardiac_valve_regurgitation0.41588319
169MP0005551_abnormal_eye_electrophysiolog0.40965886
170MP0001944_abnormal_pancreas_morphology0.40854771
171MP0005253_abnormal_eye_physiology0.40847947
172MP0000249_abnormal_blood_vessel0.40579635
173MP0002139_abnormal_hepatobiliary_system0.39986367
174MP0005076_abnormal_cell_differentiation0.39474201
175MP0003191_abnormal_cellular_cholesterol0.38977012
176MP0001299_abnormal_eye_distance/0.38577837
177MP0005508_abnormal_skeleton_morphology0.38355438

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)6.93357342
2Abnormal gallbladder physiology (HP:0012438)6.34911628
3Cholecystitis (HP:0001082)6.34911628
4Abnormality of the nasal mucosa (HP:0000433)5.77940146
5Focal motor seizures (HP:0011153)4.62252528
6Peripheral hypomyelination (HP:0007182)4.57842220
7Recurrent sinusitis (HP:0011108)4.55932939
8Hyperventilation (HP:0002883)4.45240805
9Infertility (HP:0000789)4.23349427
10Male infertility (HP:0003251)4.07477119
11Recurrent otitis media (HP:0000403)4.03138398
12Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.98516709
13Epileptic encephalopathy (HP:0200134)3.90707046
14Dynein arm defect of respiratory motile cilia (HP:0012255)3.62008839
15Absent/shortened dynein arms (HP:0200106)3.62008839
16Progressive inability to walk (HP:0002505)3.55385862
17Occipital encephalocele (HP:0002085)3.54029961
18Gaze-evoked nystagmus (HP:0000640)3.47597150
19Submucous cleft hard palate (HP:0000176)3.37955822
20Dysmetric saccades (HP:0000641)3.37818588
21Pancreatic fibrosis (HP:0100732)3.27118732
22True hermaphroditism (HP:0010459)3.21252157
23Febrile seizures (HP:0002373)3.12109881
24Atelectasis (HP:0100750)3.10684573
25Progressive cerebellar ataxia (HP:0002073)3.08356716
26Atonic seizures (HP:0010819)3.04667059
27Abnormality of ocular smooth pursuit (HP:0000617)3.00088104
28Abnormal ciliary motility (HP:0012262)2.98589596
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.95946625
30Hyperactive renin-angiotensin system (HP:0000841)2.95546766
31Dysdiadochokinesis (HP:0002075)2.85604449
32Impaired smooth pursuit (HP:0007772)2.83293045
33Abnormal respiratory motile cilium morphology (HP:0005938)2.82465429
34Abnormal respiratory epithelium morphology (HP:0012253)2.82465429
35Abnormality of the lower motor neuron (HP:0002366)2.82113888
36Abnormal respiratory motile cilium physiology (HP:0012261)2.78926496
37Cystic liver disease (HP:0006706)2.78881614
38Truncal ataxia (HP:0002078)2.77004593
39Fetal akinesia sequence (HP:0001989)2.76723927
40Absent eyebrow (HP:0002223)2.73357270
41Molar tooth sign on MRI (HP:0002419)2.72673708
42Abnormality of midbrain morphology (HP:0002418)2.72673708
43Abnormal hair whorl (HP:0010721)2.65589843
44Pancreatic cysts (HP:0001737)2.65117136
45Nephronophthisis (HP:0000090)2.63986405
46Focal seizures (HP:0007359)2.60026228
47Stomach cancer (HP:0012126)2.56050712
48Cholelithiasis (HP:0001081)2.55020436
49Systemic lupus erythematosus (HP:0002725)2.51284842
50Genetic anticipation (HP:0003743)2.49323368
51Thyroid-stimulating hormone excess (HP:0002925)2.48990185
52Chronic hepatic failure (HP:0100626)2.48586523
53Rhinitis (HP:0012384)2.47195211
54Neurofibrillary tangles (HP:0002185)2.46371182
55Tubulointerstitial nephritis (HP:0001970)2.45475360
56Pheochromocytoma (HP:0002666)2.44847252
57Abnormality of B cell number (HP:0010975)2.44380523
58B lymphocytopenia (HP:0010976)2.44380523
59Inability to walk (HP:0002540)2.39194807
60Annular pancreas (HP:0001734)2.38694923
61Aqueductal stenosis (HP:0002410)2.32631495
62Broad-based gait (HP:0002136)2.31123756
63Postaxial foot polydactyly (HP:0001830)2.30265973
64Absent frontal sinuses (HP:0002688)2.27520138
65Abnormal gallbladder morphology (HP:0012437)2.27019561
66Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.24458557
67Myokymia (HP:0002411)2.23763999
68Neurodegeneration (HP:0002180)2.22478168
69Reticulocytosis (HP:0001923)2.20551642
70Limb ataxia (HP:0002070)2.20284589
71Hypoplasia of the thymus (HP:0000778)2.16717066
72Recurrent bronchitis (HP:0002837)2.13984113
73Protruding tongue (HP:0010808)2.13867330
74Chronic sinusitis (HP:0011109)2.13219521
75Action tremor (HP:0002345)2.12665747
76Increased neuronal autofluorescent lipopigment (HP:0002074)2.11065973
77Bell-shaped thorax (HP:0001591)2.11021726
78Absent eyelashes (HP:0000561)2.09550504
79Chronic bronchitis (HP:0004469)2.08643932
80Optic nerve coloboma (HP:0000588)2.04774985
81Neuroendocrine neoplasm (HP:0100634)2.04750934
82Depression (HP:0000716)2.02980203
83Abnormality of the renal medulla (HP:0100957)2.02615609
84Hypothermia (HP:0002045)2.02124760
85Chronic otitis media (HP:0000389)2.00056509
86Bronchiectasis (HP:0002110)1.99690060
87Genital tract atresia (HP:0001827)1.99343254
88Excessive salivation (HP:0003781)1.99305705
89Drooling (HP:0002307)1.99305705
90Abnormality of the nasolacrimal system (HP:0000614)1.99098558
91Congenital hepatic fibrosis (HP:0002612)1.96992799
92Vaginal atresia (HP:0000148)1.96970787
93Morphological abnormality of the middle ear (HP:0008609)1.95068020
94Abnormality of saccadic eye movements (HP:0000570)1.93996955
95Exercise-induced myalgia (HP:0003738)1.93850049
96Cupped ear (HP:0000378)1.93421915
97Hemiplegia (HP:0002301)1.93215492
98Spinal canal stenosis (HP:0003416)1.92069537
99Generalized tonic-clonic seizures (HP:0002069)1.91834224
100Retrobulbar optic neuritis (HP:0100654)1.90827934
101Optic neuritis (HP:0100653)1.90827934
102Supranuclear gaze palsy (HP:0000605)1.90175993
103Anencephaly (HP:0002323)1.89722097
104Abnormality of the lacrimal duct (HP:0011481)1.89552932
105Decreased circulating renin level (HP:0003351)1.87540723
106Abnormality of the gallbladder (HP:0005264)1.86752018
107Stereotypic behavior (HP:0000733)1.86045849
108Increased cerebral lipofuscin (HP:0011813)1.85605067
109Hyperkalemia (HP:0002153)1.80796609
110Aplasia/Hypoplasia of the tongue (HP:0010295)1.79785155
111Dysmetria (HP:0001310)1.79229143
112Urinary bladder sphincter dysfunction (HP:0002839)1.78539620
113Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.77555012
114Diplopia (HP:0000651)1.76284464
115Abnormality of binocular vision (HP:0011514)1.76284464
116Male pseudohermaphroditism (HP:0000037)1.76131311
117Anxiety (HP:0000739)1.75695905
118Scanning speech (HP:0002168)1.74522917
119Thickened helices (HP:0000391)1.73761080
120Asplenia (HP:0001746)1.73683011
121Aplasia/Hypoplasia of the spleen (HP:0010451)1.73594685
122Postural tremor (HP:0002174)1.72903817
123Renal salt wasting (HP:0000127)1.72403513
124Dialeptic seizures (HP:0011146)1.71889300
125Bronchitis (HP:0012387)1.71765160
1262-3 toe syndactyly (HP:0004691)1.71045901
127Abnormal lung lobation (HP:0002101)1.70823900
128Clumsiness (HP:0002312)1.69682887
129Delusions (HP:0000746)1.68291413
130Cerebral inclusion bodies (HP:0100314)1.67551353
131Tubular atrophy (HP:0000092)1.64741864
132Medial flaring of the eyebrow (HP:0010747)1.61264678
133Oculomotor apraxia (HP:0000657)1.58923785
134Nephropathy (HP:0000112)1.57377711
135Furrowed tongue (HP:0000221)1.54553747
136Congenital primary aphakia (HP:0007707)1.50964482
137Sclerocornea (HP:0000647)1.49071386
138Gait imbalance (HP:0002141)1.47242871
139Aplasia of the musculature (HP:0100854)1.45709513
140Hyperaldosteronism (HP:0000859)1.42427633
141Abnormality of the frontal sinuses (HP:0002687)1.42346790
142Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.41831256
143Postaxial hand polydactyly (HP:0001162)1.41156576
144Abnormality of renin-angiotensin system (HP:0000847)1.35600116
145Obstructive sleep apnea (HP:0002870)1.35484893
146Decreased central vision (HP:0007663)1.35101430
147Abnormality of chloride homeostasis (HP:0011422)1.34835566
148Abnormality of the distal phalanges of the toes (HP:0010182)1.32269029
149Hand muscle atrophy (HP:0009130)1.32254674
150Nephrogenic diabetes insipidus (HP:0009806)1.29391549
151Short thorax (HP:0010306)1.28959350
152Lip pit (HP:0100267)1.24978574
153Short nail (HP:0001799)1.21235960
154Cone-rod dystrophy (HP:0000548)1.20631715
155Glucose intolerance (HP:0000833)1.20218681
156Popliteal pterygium (HP:0009756)1.18253483
157Hypokalemic alkalosis (HP:0001949)1.17931034
158Preaxial hand polydactyly (HP:0001177)1.16883938
159Tubulointerstitial abnormality (HP:0001969)1.13300787
160Absent rod-and cone-mediated responses on ERG (HP:0007688)1.13020295
161Median cleft lip (HP:0000161)1.12778535
162Hyponatremia (HP:0002902)1.12763843
163Stage 5 chronic kidney disease (HP:0003774)1.11654226
164Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.11344148
165Abnormality of permanent molar morphology (HP:0011071)1.10678143
166Abnormality of the dental root (HP:0006486)1.10678143
167Taurodontia (HP:0000679)1.10678143
168Flat acetabular roof (HP:0003180)1.09717853
169Bifid scrotum (HP:0000048)1.08709738
170Spinal muscular atrophy (HP:0007269)1.07555581
171Short femoral neck (HP:0100864)1.04149249
172Self-mutilation (HP:0000742)1.04000563
173Poor coordination (HP:0002370)1.03454048
174Stridor (HP:0010307)1.03207045
175Abnormality of molar morphology (HP:0011070)1.01221386
176Abnormality of molar (HP:0011077)1.01221386
177Abnormality of monocarboxylic acid metabolism (HP:0010996)1.00788340
178Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.00121648
179Abnormal drinking behavior (HP:0030082)0.99553898
180Polydipsia (HP:0001959)0.99553898
181Muscle fiber splitting (HP:0003555)0.98586542
182Carpal bone hypoplasia (HP:0001498)0.98569643
183Abnormality of the dental pulp (HP:0006479)0.97965534

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.73067898
2MST45.21021216
3SIK35.13036217
4EPHA24.80101512
5SIK22.76225404
6TNIK2.70626704
7PRPF4B2.67067227
8PTK2B2.53470198
9MAP2K72.50728776
10MUSK2.40217031
11MAP4K12.31870308
12NME12.30523820
13SMG12.19608675
14TLK12.13020168
15EEF2K2.10329290
16MAPKAPK31.98374949
17NTRK31.98173974
18FGFR21.82569015
19MINK11.80111095
20STK241.80094888
21ZAP701.71961271
22MAP3K31.71242603
23MAP3K121.69833173
24EPHA41.66148635
25TTK1.61663226
26MAP2K41.60534475
27MAP3K41.55126759
28BTK1.53590774
29MAP3K71.53574954
30AKT31.53547670
31CSK1.52617791
32YES11.52069876
33BLK1.51770180
34TAOK21.47002395
35MAPK71.43479896
36DMPK1.37653150
37MST1R1.35099232
38SGK21.32113933
39TRIB31.28570131
40CDK121.22193166
41FES1.19541595
42TXK1.14991262
43NEK61.11851776
44EPHB11.11492221
45MAPK131.10999750
46PINK11.09211748
47CAMK41.08525487
48CDK191.05928646
49UHMK11.05616450
50LRRK21.04685547
51TBK11.03520651
52DAPK11.02852847
53CAMK11.02040919
54STK101.01317873
55TRPM71.00140932
56CCNB10.99548494
57ITK0.99030716
58CDK30.99026283
59ICK0.98424715
60EPHA30.95788239
61PLK20.95711201
62BCR0.94040672
63MKNK20.93930153
64MAPK120.93601972
65SGK4940.91718401
66SGK2230.91718401
67ADRBK20.90830407
68SYK0.89251317
69MAPKAPK50.88726099
70MAP3K90.87796608
71FRK0.87078745
72GRK60.83627292
73CAMKK10.80431810
74TSSK60.80073538
75FLT30.79944640
76STK380.79599627
77MAP2K30.79504734
78TEC0.78953494
79HCK0.77354206
80PTK60.76396848
81DAPK20.76125256
82MARK20.73793020
83CAMKK20.71723721
84KIT0.70784680
85ERBB20.70327290
86SGK30.66793217
87PRKCI0.66221157
88KSR10.66155515
89RIPK40.66068699
90TESK10.65090593
91PRKD30.62973934
92NEK20.62109426
93TYK20.59425029
94FER0.58175047
95PRKCG0.57223432
96CDK50.56764491
97MAP3K60.56345148
98MAPK150.54916966
99RIPK10.52124714
100WNK10.51278098
101HIPK20.50037166
102CAMK2A0.49365126
103OXSR10.49034326
104MATK0.48228691
105PDPK10.47642233
106NTRK20.47554378
107TGFBR20.47349833
108PHKG20.46880861
109PHKG10.46880861
110DYRK1B0.46831211
111PRKAA20.46365152
112PAK40.46289446
113ERBB30.45607512
114CAMK2B0.44799027
115LCK0.44567946
116LYN0.44497494
117CDK60.44164826
118PRKCD0.42223278
119CAMK2G0.41934833
120TNK20.40953893
121FGR0.40531679
122AURKA0.39801937
123MKNK10.39349278
124PNCK0.39254932
125TESK20.38342145
126SRC0.38239762
127CDC42BPA0.37934369
128SGK10.37164905
129TAOK10.37060921
130GRK50.36596385
131PDK10.35859073
132STK160.34652039
133PRKCQ0.33674820
134CDK180.33466605
135PRKACB0.32338215
136JAK10.31972379
137MAP3K140.31862863
138PRKD20.31513107
139CSF1R0.30628674
140BRSK20.30555772
141RPS6KA20.30211587
142MAP3K20.28363067
143RPS6KB20.27390129
144NLK0.26655435
145MAPK110.26445087
146MET0.26180739
147CAMK1D0.26116326
148PIM20.25559192
149PRKCE0.25289538
150MAPK40.25185635
151ADRBK10.24727278
152ERN10.21751950
153PBK0.21707752
154MAP3K50.21623579
155RET0.20629772
156FGFR30.20325773
157LATS10.17713761
158PAK10.17623250
159ABL10.17622951
160FYN0.17572768
161ROCK20.16957048
162PRKACA0.16771353
163IRAK10.16444170
164ILK0.16139264
165ROCK10.16113934
166PRKCA0.15194279
167NEK90.14693425
168LMTK20.14074097
169PRKAA10.13214337
170MAP2K20.12862032
171PRKCH0.12767149
172BMPR20.12724637
173MELK0.12483837

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.68738434
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.63297543
3Phenylalanine metabolism_Homo sapiens_hsa003604.96641687
4Histidine metabolism_Homo sapiens_hsa003404.58918919
5Chemical carcinogenesis_Homo sapiens_hsa052044.44741307
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.12548984
7Tyrosine metabolism_Homo sapiens_hsa003503.69982760
8Nicotine addiction_Homo sapiens_hsa050333.59745496
9beta-Alanine metabolism_Homo sapiens_hsa004102.83357024
10Glutathione metabolism_Homo sapiens_hsa004802.50392333
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.44360943
12Huntingtons disease_Homo sapiens_hsa050162.41511599
13Collecting duct acid secretion_Homo sapiens_hsa049662.36862543
14Synaptic vesicle cycle_Homo sapiens_hsa047212.35724649
15GABAergic synapse_Homo sapiens_hsa047272.28421532
16Glutamatergic synapse_Homo sapiens_hsa047242.25661179
17Caffeine metabolism_Homo sapiens_hsa002322.21807680
18Circadian entrainment_Homo sapiens_hsa047132.18719716
19Morphine addiction_Homo sapiens_hsa050322.15234884
20Retinol metabolism_Homo sapiens_hsa008302.08059297
21Sphingolipid metabolism_Homo sapiens_hsa006001.87950988
22Long-term potentiation_Homo sapiens_hsa047201.86096013
23Linoleic acid metabolism_Homo sapiens_hsa005911.77778654
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73114529
25Circadian rhythm_Homo sapiens_hsa047101.65250530
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57272980
27Amphetamine addiction_Homo sapiens_hsa050311.56160725
28Fructose and mannose metabolism_Homo sapiens_hsa000511.55306507
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.52201170
30Taste transduction_Homo sapiens_hsa047421.49489040
31Salivary secretion_Homo sapiens_hsa049701.49472272
32Insulin secretion_Homo sapiens_hsa049111.44450919
33Tight junction_Homo sapiens_hsa045301.38842612
34Calcium signaling pathway_Homo sapiens_hsa040201.37029755
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31888865
36Long-term depression_Homo sapiens_hsa047301.29680752
37Olfactory transduction_Homo sapiens_hsa047401.28300224
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.27929543
39Type II diabetes mellitus_Homo sapiens_hsa049301.26380915
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24143814
41Carbohydrate digestion and absorption_Homo sapiens_hsa049731.23943085
42Dopaminergic synapse_Homo sapiens_hsa047281.21727778
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21222801
44Gastric acid secretion_Homo sapiens_hsa049711.20999884
45Oxytocin signaling pathway_Homo sapiens_hsa049211.20356952
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19599283
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17355389
48cAMP signaling pathway_Homo sapiens_hsa040241.15305687
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15176918
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14781796
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13826831
52Serotonergic synapse_Homo sapiens_hsa047261.12426783
53Cocaine addiction_Homo sapiens_hsa050301.08168348
54Renin secretion_Homo sapiens_hsa049241.07898347
55Cholinergic synapse_Homo sapiens_hsa047251.07081145
56Notch signaling pathway_Homo sapiens_hsa043301.06504544
57Hepatitis C_Homo sapiens_hsa051600.99038293
58Vibrio cholerae infection_Homo sapiens_hsa051100.97097691
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96800359
60Fatty acid degradation_Homo sapiens_hsa000710.95714600
61Arachidonic acid metabolism_Homo sapiens_hsa005900.94136248
62Peroxisome_Homo sapiens_hsa041460.91528663
63Rheumatoid arthritis_Homo sapiens_hsa053230.91426212
64Choline metabolism in cancer_Homo sapiens_hsa052310.88260829
65Staphylococcus aureus infection_Homo sapiens_hsa051500.83301182
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83203777
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81740308
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.80115614
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79662569
70Inositol phosphate metabolism_Homo sapiens_hsa005620.77716068
71Axon guidance_Homo sapiens_hsa043600.76506371
72B cell receptor signaling pathway_Homo sapiens_hsa046620.76370963
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71580699
74Phagosome_Homo sapiens_hsa041450.71282194
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.70354655
76Adherens junction_Homo sapiens_hsa045200.70241368
77Leishmaniasis_Homo sapiens_hsa051400.68867641
78GnRH signaling pathway_Homo sapiens_hsa049120.67869255
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66937854
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66310901
81MAPK signaling pathway_Homo sapiens_hsa040100.65896041
82Pancreatic secretion_Homo sapiens_hsa049720.65671134
83Hedgehog signaling pathway_Homo sapiens_hsa043400.65580898
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.65466350
85Arginine biosynthesis_Homo sapiens_hsa002200.64773995
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.64207362
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62960470
88Gap junction_Homo sapiens_hsa045400.62136480
89Hematopoietic cell lineage_Homo sapiens_hsa046400.61004915
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60659817
91Primary immunodeficiency_Homo sapiens_hsa053400.60372523
92Pertussis_Homo sapiens_hsa051330.60353116
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59715290
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.58232310
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56078522
96Complement and coagulation cascades_Homo sapiens_hsa046100.55893459
97Platelet activation_Homo sapiens_hsa046110.55805196
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54874154
99Galactose metabolism_Homo sapiens_hsa000520.53892459
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53336354
101ABC transporters_Homo sapiens_hsa020100.53113985
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51648741
103Lysosome_Homo sapiens_hsa041420.51428547
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.50942095
105Glucagon signaling pathway_Homo sapiens_hsa049220.50160806
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.49818444
107T cell receptor signaling pathway_Homo sapiens_hsa046600.49619133
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48991323
109Osteoclast differentiation_Homo sapiens_hsa043800.48884901
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48705565
111Dilated cardiomyopathy_Homo sapiens_hsa054140.48405829
112ErbB signaling pathway_Homo sapiens_hsa040120.47863711
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47056169
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45954078
115Estrogen signaling pathway_Homo sapiens_hsa049150.44731747
116Basal cell carcinoma_Homo sapiens_hsa052170.44659825
117Chemokine signaling pathway_Homo sapiens_hsa040620.43552568
118Starch and sucrose metabolism_Homo sapiens_hsa005000.42178637
119Salmonella infection_Homo sapiens_hsa051320.42164183
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42083199
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.41962323
122Type I diabetes mellitus_Homo sapiens_hsa049400.41894262
123HIF-1 signaling pathway_Homo sapiens_hsa040660.41680375
124PPAR signaling pathway_Homo sapiens_hsa033200.39980718
125Vitamin B6 metabolism_Homo sapiens_hsa007500.39103096
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38773012
127Insulin signaling pathway_Homo sapiens_hsa049100.38390853
128Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37857891
129Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37098873
130Amoebiasis_Homo sapiens_hsa051460.36079519
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35352139
132Thyroid hormone synthesis_Homo sapiens_hsa049180.33908813
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33364879
134Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32860370
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.32542352
136Insulin resistance_Homo sapiens_hsa049310.31798928
137Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31788601
138Toxoplasmosis_Homo sapiens_hsa051450.31654895
139Vitamin digestion and absorption_Homo sapiens_hsa049770.31312813
140Rap1 signaling pathway_Homo sapiens_hsa040150.31300419
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.31299542
142Ras signaling pathway_Homo sapiens_hsa040140.31169226
143Intestinal immune network for IgA production_Homo sapiens_hsa046720.30975116
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29724852
145Hippo signaling pathway_Homo sapiens_hsa043900.28439734
146Endocytosis_Homo sapiens_hsa041440.27074798
147Allograft rejection_Homo sapiens_hsa053300.25512381
148Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24921007
149Phototransduction_Homo sapiens_hsa047440.23684172
150Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22771160
151Fatty acid biosynthesis_Homo sapiens_hsa000610.18376694
152Influenza A_Homo sapiens_hsa051640.17881419
153Metabolic pathways_Homo sapiens_hsa011000.17147728
154Apoptosis_Homo sapiens_hsa042100.16778210
155Prostate cancer_Homo sapiens_hsa052150.15941251
156Graft-versus-host disease_Homo sapiens_hsa053320.15873280
157Autoimmune thyroid disease_Homo sapiens_hsa053200.15361977
158Primary bile acid biosynthesis_Homo sapiens_hsa001200.15334986
159Glycerolipid metabolism_Homo sapiens_hsa005610.15240728
160Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14015594
161Melanogenesis_Homo sapiens_hsa049160.12530540
162Ovarian steroidogenesis_Homo sapiens_hsa049130.11474838
163Arginine and proline metabolism_Homo sapiens_hsa003300.11412778
164mTOR signaling pathway_Homo sapiens_hsa041500.09811200
165Regulation of autophagy_Homo sapiens_hsa041400.08825371

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