DCDC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of DNA methylation (GO:0044030)6.29566056
2regulation of acrosome reaction (GO:0060046)6.24193227
3piRNA metabolic process (GO:0034587)5.99419894
4regulation of female gonad development (GO:2000194)5.78483356
5regulation of meiosis I (GO:0060631)5.67053085
6meiotic cell cycle (GO:0051321)5.35255354
7intestinal cholesterol absorption (GO:0030299)4.88758036
8retinal cone cell development (GO:0046549)4.87244888
9very-low-density lipoprotein particle assembly (GO:0034379)4.80372978
10DNA methylation involved in gamete generation (GO:0043046)4.67879512
11plasma lipoprotein particle assembly (GO:0034377)4.43339815
12negative regulation of fibrinolysis (GO:0051918)4.34004635
13cholesterol efflux (GO:0033344)4.17503379
14low-density lipoprotein particle remodeling (GO:0034374)4.14776155
15regulation of protein activation cascade (GO:2000257)4.14744917
16regulation of complement activation (GO:0030449)4.09400755
17regulation of fibrinolysis (GO:0051917)4.06238569
18positive regulation of histone H3-K4 methylation (GO:0051571)4.05950508
19positive regulation of hormone metabolic process (GO:0032352)4.05444857
20regulation of bile acid biosynthetic process (GO:0070857)3.90442016
21female gamete generation (GO:0007292)3.88338706
22gene silencing by RNA (GO:0031047)3.86909961
23protein carboxylation (GO:0018214)3.85370929
24peptidyl-glutamic acid carboxylation (GO:0017187)3.85370929
25regulation of steroid hormone biosynthetic process (GO:0090030)3.85000589
26L-phenylalanine metabolic process (GO:0006558)3.83048062
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.83048062
28oocyte development (GO:0048599)3.82438927
29regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.78203094
30L-phenylalanine catabolic process (GO:0006559)3.73913582
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.73913582
32protein-lipid complex assembly (GO:0065005)3.73725474
33positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.68760719
34positive regulation of mitotic sister chromatid separation (GO:1901970)3.68760719
35positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.68760719
36positive regulation of gastrulation (GO:2000543)3.68757917
37multicellular organism reproduction (GO:0032504)3.65497001
38positive regulation of cellular amine metabolic process (GO:0033240)3.59600012
39positive regulation of hormone biosynthetic process (GO:0046886)3.59368323
40regulation of apoptotic cell clearance (GO:2000425)3.54981956
41plasma lipoprotein particle remodeling (GO:0034369)3.50966595
42protein-lipid complex remodeling (GO:0034368)3.50966595
43macromolecular complex remodeling (GO:0034367)3.50966595
44negative regulation of reproductive process (GO:2000242)3.43758429
45negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.43386068
46regulation of cholesterol esterification (GO:0010872)3.39769587
47primitive streak formation (GO:0090009)3.35953054
48regulation of retinoic acid receptor signaling pathway (GO:0048385)3.33654330
49regulation of non-canonical Wnt signaling pathway (GO:2000050)3.32863936
50high-density lipoprotein particle remodeling (GO:0034375)3.30833559
51pyrimidine-containing compound transmembrane transport (GO:0072531)3.30652098
52intestinal absorption (GO:0050892)3.28512478
53regulation of cell maturation (GO:1903429)3.26853574
54plasma lipoprotein particle organization (GO:0071827)3.25950325
55negative regulation of hormone metabolic process (GO:0032351)3.25336507
56negative regulation of lipase activity (GO:0060192)3.21383234
57glycine transport (GO:0015816)3.19982589
58centriole replication (GO:0007099)3.19600707
59negative regulation of execution phase of apoptosis (GO:1900118)3.17103759
60negative regulation of protein activation cascade (GO:2000258)3.16116061
61regulation of steroid hormone secretion (GO:2000831)3.15178476
62regulation of histone H3-K9 methylation (GO:0051570)3.14334975
63embryonic retina morphogenesis in camera-type eye (GO:0060059)3.11640026
64regulation of meiosis (GO:0040020)3.11562843
65drug transmembrane transport (GO:0006855)3.09847084
66somite rostral/caudal axis specification (GO:0032525)3.08847179
67transepithelial transport (GO:0070633)3.03678088
68cholesterol transport (GO:0030301)3.03153250
69sterol transport (GO:0015918)3.03153250
70vitamin transmembrane transport (GO:0035461)3.02373247
71positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.02258167
72reverse cholesterol transport (GO:0043691)3.01147794
73blood coagulation, intrinsic pathway (GO:0007597)2.98344465
74protein-lipid complex subunit organization (GO:0071825)2.95093381
75artery smooth muscle contraction (GO:0014824)2.88205307
76male meiosis I (GO:0007141)2.87944122
77negative regulation of hormone biosynthetic process (GO:0032353)2.87781109
78plasma lipoprotein particle clearance (GO:0034381)2.85392158
79epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.84208093
80negative regulation of cholesterol transport (GO:0032375)2.84162846
81negative regulation of sterol transport (GO:0032372)2.84162846
82drinking behavior (GO:0042756)2.80103825
83modified amino acid transport (GO:0072337)2.78128537
84regulation of humoral immune response (GO:0002920)2.77439995
85negative regulation of histone methylation (GO:0031061)2.76596953
86nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.75986282
87synaptonemal complex assembly (GO:0007130)2.73225849
88urate metabolic process (GO:0046415)2.72856816
89regulation of norepinephrine secretion (GO:0014061)2.71808200
90regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.71350392
91lung epithelium development (GO:0060428)2.70783914
92cholesterol homeostasis (GO:0042632)2.70381993
93sterol homeostasis (GO:0055092)2.70087753
94nephron epithelium morphogenesis (GO:0072088)2.69786159
95nephron tubule morphogenesis (GO:0072078)2.69786159
96male meiosis (GO:0007140)2.69505248
97positive regulation of steroid metabolic process (GO:0045940)2.65644246
98positive regulation of chromosome segregation (GO:0051984)2.62666961
99regulation of cholesterol homeostasis (GO:2000188)2.62398261
100negative regulation of complement activation (GO:0045916)2.61974610

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.68323062
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.80221065
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.58639190
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.54572243
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.13142469
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.09239202
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.84945290
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59536323
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.56226672
10GBX2_23144817_ChIP-Seq_PC3_Human2.53075901
11* FOXA2_19822575_ChIP-Seq_HepG2_Human2.51841466
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.45001392
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23177137
14ESR1_15608294_ChIP-ChIP_MCF-7_Human2.18594996
15AHR_22903824_ChIP-Seq_MCF-7_Human2.08356428
16ESR1_20079471_ChIP-ChIP_T-47D_Human2.04897625
17FOXM1_26456572_ChIP-Seq_MCF-7_Human1.96699257
18LXR_22158963_ChIP-Seq_LIVER_Mouse1.96677440
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95112242
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.87433407
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.87433407
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.87433407
23EP300_21415370_ChIP-Seq_HL-1_Mouse1.84486109
24* HNF4A_19822575_ChIP-Seq_HepG2_Human1.82694315
25ARNT_22903824_ChIP-Seq_MCF-7_Human1.81447987
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.80603727
27ZNF274_21170338_ChIP-Seq_K562_Hela1.80100262
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.77036254
29HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.69797983
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68735217
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.67256549
32RXR_22158963_ChIP-Seq_LIVER_Mouse1.65520171
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.65443463
34* ESR1_21235772_ChIP-Seq_MCF-7_Human1.63291770
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.61708529
36AR_21909140_ChIP-Seq_LNCAP_Human1.55824667
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.54396405
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53223067
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49685186
40FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.48731880
41ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48627119
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48243294
43TP53_16413492_ChIP-PET_HCT116_Human1.45606152
44GATA4_25053715_ChIP-Seq_YYC3_Human1.39528922
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.35038973
46* TCF4_23295773_ChIP-Seq_U87_Human1.32252393
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31079106
48* ESR2_21235772_ChIP-Seq_MCF-7_Human1.29247264
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27798089
50STAT3_23295773_ChIP-Seq_U87_Human1.25877518
51CTNNB1_20460455_ChIP-Seq_HCT116_Human1.25608428
52AR_25329375_ChIP-Seq_VCAP_Human1.25351912
53* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25049006
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23566728
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22695978
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.22243174
57ER_23166858_ChIP-Seq_MCF-7_Human1.20254638
58SMAD4_21741376_ChIP-Seq_EPCs_Human1.19101455
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19093192
60* SMAD4_21799915_ChIP-Seq_A2780_Human1.18254587
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17661831
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17478906
63CBP_20019798_ChIP-Seq_JUKART_Human1.17478906
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16135005
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.14165719
66P300_19829295_ChIP-Seq_ESCs_Human1.13958405
67TCF4_18268006_ChIP-ChIP_LS174T_Human1.13005829
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12061959
69CDX2_22108803_ChIP-Seq_LS180_Human1.12058413
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11706969
71GATA3_24758297_ChIP-Seq_MCF-7_Human1.09980945
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09884089
73RUNX2_22187159_ChIP-Seq_PCA_Human1.09779266
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08716430
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.07828136
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06463504
77TAF15_26573619_Chip-Seq_HEK293_Human1.04432804
78VDR_22108803_ChIP-Seq_LS180_Human1.04094652
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00557781
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00005268
81SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99772044
82PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99405967
83* FOXA1_25552417_ChIP-Seq_VCAP_Human0.99117673
84GATA6_25053715_ChIP-Seq_YYC3_Human0.98544849
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97708377
86TCF4_22108803_ChIP-Seq_LS180_Human0.95407906
87STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93772350
88AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93648378
89PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93000858
90EWS_26573619_Chip-Seq_HEK293_Human0.92398537
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90623325
92HTT_18923047_ChIP-ChIP_STHdh_Human0.89552996
93SMAD4_21741376_ChIP-Seq_HESCs_Human0.89173590
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88416714
95NANOG_19829295_ChIP-Seq_ESCs_Human0.86434362
96SOX2_19829295_ChIP-Seq_ESCs_Human0.86434362
97FOXH1_21741376_ChIP-Seq_EPCs_Human0.85646343
98CJUN_26792858_Chip-Seq_BT549_Human0.84675736
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84542041
100TP63_19390658_ChIP-ChIP_HaCaT_Human0.83799920

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.60027210
2MP0003718_maternal_effect4.82898350
3MP0003195_calcinosis4.19635560
4MP0002138_abnormal_hepatobiliary_system3.84372505
5MP0005360_urolithiasis3.40961922
6MP0003252_abnormal_bile_duct3.00731489
7MP0003122_maternal_imprinting2.98420811
8MP0000566_synostosis2.87618099
9MP0001666_abnormal_nutrient_absorption2.82788467
10MP0003890_abnormal_embryonic-extraembry2.70037075
11MP0006292_abnormal_olfactory_placode2.59761342
12MP0005365_abnormal_bile_salt2.59301815
13MP0009780_abnormal_chondrocyte_physiolo2.55636864
14MP0008877_abnormal_DNA_methylation2.47618467
15MP0005085_abnormal_gallbladder_physiolo2.42487349
16MP0010234_abnormal_vibrissa_follicle2.36693996
17MP0005395_other_phenotype2.29928383
18MP0008789_abnormal_olfactory_epithelium2.28714254
19MP0003868_abnormal_feces_composition2.08195331
20MP0005499_abnormal_olfactory_system2.07349515
21MP0005394_taste/olfaction_phenotype2.07349515
22MP0003183_abnormal_peptide_metabolism1.95541197
23MP0003121_genomic_imprinting1.94954497
24MP0008875_abnormal_xenobiotic_pharmacok1.91427134
25MP0010329_abnormal_lipoprotein_level1.84336694
26MP0003950_abnormal_plasma_membrane1.82486586
27MP0003879_abnormal_hair_cell1.74504762
28MP0002928_abnormal_bile_duct1.74123954
29MP0002160_abnormal_reproductive_system1.70496719
30MP0004043_abnormal_pH_regulation1.70366367
31MP0005410_abnormal_fertilization1.68817701
32MP0003699_abnormal_female_reproductive1.56510802
33MP0002089_abnormal_postnatal_growth/wei1.51818637
34MP0005408_hypopigmentation1.49175723
35MP0002234_abnormal_pharynx_morphology1.47210398
36MP0001929_abnormal_gametogenesis1.46513881
37MP0009840_abnormal_foam_cell1.45098391
38MP0005646_abnormal_pituitary_gland1.44676339
39MP0003941_abnormal_skin_development1.40077028
40MP0010678_abnormal_skin_adnexa1.34168727
41MP0010030_abnormal_orbit_morphology1.26455061
42MP0002210_abnormal_sex_determination1.25594999
43MP0001293_anophthalmia1.20489835
44MP0003693_abnormal_embryo_hatching1.18907384
45MP0005220_abnormal_exocrine_pancreas1.18844140
46MP0002132_abnormal_respiratory_system1.17988565
47MP0001756_abnormal_urination1.17962956
48MP0002161_abnormal_fertility/fecundity1.16181214
49MP0000653_abnormal_sex_gland1.15518768
50MP0010368_abnormal_lymphatic_system1.14515056
51MP0002233_abnormal_nose_morphology1.14378717
52MP0005551_abnormal_eye_electrophysiolog1.13907123
53MP0003123_paternal_imprinting1.11148231
54MP0004019_abnormal_vitamin_homeostasis1.09494414
55MP0001944_abnormal_pancreas_morphology1.05026601
56MP0001984_abnormal_olfaction1.04936566
57MP0005332_abnormal_amino_acid1.01668149
58MP0001324_abnormal_eye_pigmentation1.00570812
59MP0005084_abnormal_gallbladder_morpholo0.99389006
60MP0003943_abnormal_hepatobiliary_system0.97721434
61MP0005389_reproductive_system_phenotype0.97235039
62MP0001145_abnormal_male_reproductive0.95865078
63MP0003698_abnormal_male_reproductive0.95825498
64MP0000762_abnormal_tongue_morphology0.89153168
65MP0002909_abnormal_adrenal_gland0.88274916
66MP0000383_abnormal_hair_follicle0.88245621
67MP0001270_distended_abdomen0.86007318
68MP0002118_abnormal_lipid_homeostasis0.84005833
69MP0008057_abnormal_DNA_replication0.83616803
70MP0000631_abnormal_neuroendocrine_gland0.82387521
71MP0003136_yellow_coat_color0.80745493
72MP0002876_abnormal_thyroid_physiology0.79552305
73MP0001664_abnormal_digestion0.77698617
74MP0005379_endocrine/exocrine_gland_phen0.76545752
75MP0005647_abnormal_sex_gland0.75740887
76MP0001119_abnormal_female_reproductive0.73916326
77MP0000427_abnormal_hair_cycle0.71230404
78MP0010386_abnormal_urinary_bladder0.70213973
79MP0005076_abnormal_cell_differentiation0.66284986
80MP0005409_darkened_coat_color0.65589062
81MP0010307_abnormal_tumor_latency0.64339900
82MP0003942_abnormal_urinary_system0.64036041
83MP0000639_abnormal_adrenal_gland0.63559588
84MP0004264_abnormal_extraembryonic_tissu0.63036766
85MP0001286_abnormal_eye_development0.61158039
86MP0003119_abnormal_digestive_system0.60441288
87MP0008058_abnormal_DNA_repair0.59477611
88MP0001730_embryonic_growth_arrest0.58549121
89MP0002168_other_aberrant_phenotype0.57462452
90MP0005380_embryogenesis_phenotype0.56908947
91MP0001672_abnormal_embryogenesis/_devel0.56908947
92MP0000678_abnormal_parathyroid_gland0.55591045
93MP0002938_white_spotting0.54969422
94MP0005636_abnormal_mineral_homeostasis0.53513778
95MP0002163_abnormal_gland_morphology0.53491593
96MP0003953_abnormal_hormone_level0.53127395
97MP0002092_abnormal_eye_morphology0.51953956
98MP0002090_abnormal_vision0.51593794
99MP0003077_abnormal_cell_cycle0.50267962
100MP0005319_abnormal_enzyme/_coenzyme0.49954564

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.61124853
2Supernumerary spleens (HP:0009799)4.88836427
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.52637511
4Hypophosphatemic rickets (HP:0004912)4.29806151
5Prolonged partial thromboplastin time (HP:0003645)4.25159773
6Osteomalacia (HP:0002749)4.07807858
7Papillary thyroid carcinoma (HP:0002895)3.73016487
8Hypobetalipoproteinemia (HP:0003563)3.57278300
9Broad alveolar ridges (HP:0000187)3.56397942
10Azoospermia (HP:0000027)3.41476141
11Facial hemangioma (HP:0000329)3.38000104
12Intrahepatic cholestasis (HP:0001406)2.97647760
13Male infertility (HP:0003251)2.97505386
14Proximal tubulopathy (HP:0000114)2.95533175
15Flat acetabular roof (HP:0003180)2.94964360
16Vascular calcification (HP:0004934)2.93408980
17Complement deficiency (HP:0004431)2.86155735
18Abnormal tarsal ossification (HP:0008369)2.85404495
19Chromsome breakage (HP:0040012)2.82765470
20Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.74612450
21Abnormality of carpal bone ossification (HP:0006257)2.69985244
22Abnormality of monocarboxylic acid metabolism (HP:0010996)2.67694012
23Abnormality of the common coagulation pathway (HP:0010990)2.66416028
24Metaphyseal irregularity (HP:0003025)2.61118681
25Fat malabsorption (HP:0002630)2.60749965
26Joint hemorrhage (HP:0005261)2.60032440
27Hypoglycemic coma (HP:0001325)2.57451185
28Bicornuate uterus (HP:0000813)2.52530702
29Potter facies (HP:0002009)2.51872370
30Facial shape deformation (HP:0011334)2.51872370
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.50756613
32Generalized aminoaciduria (HP:0002909)2.48444740
33Cardiovascular calcification (HP:0011915)2.48277493
34Thyroid carcinoma (HP:0002890)2.42198934
35Spontaneous abortion (HP:0005268)2.41441847
36Short tibia (HP:0005736)2.41042625
37Mitral stenosis (HP:0001718)2.40872641
38Small epiphyses (HP:0010585)2.40186158
39Abdominal situs inversus (HP:0003363)2.40115901
40Abnormality of abdominal situs (HP:0011620)2.40115901
41Hypercholesterolemia (HP:0003124)2.38874020
42Fair hair (HP:0002286)2.38743189
43Lip pit (HP:0100267)2.37983627
44Infertility (HP:0000789)2.37508627
45Increased circulating renin level (HP:0000848)2.36200051
46Enlarged penis (HP:0000040)2.34246935
47Capillary hemangiomas (HP:0005306)2.32438228
48Hypothermia (HP:0002045)2.32393622
49Median cleft lip (HP:0000161)2.31380885
50Glomerulonephritis (HP:0000099)2.31019042
51Aplasia/Hypoplasia of the fovea (HP:0008060)2.30527256
52Hypoplasia of the fovea (HP:0007750)2.30527256
53Abnormal spermatogenesis (HP:0008669)2.30037566
54Nephroblastoma (Wilms tumor) (HP:0002667)2.29870451
55Striae distensae (HP:0001065)2.29707364
56Broad palm (HP:0001169)2.27512607
57Neonatal death (HP:0003811)2.25993807
58Epidermoid cyst (HP:0200040)2.24615313
59Rickets (HP:0002748)2.24173510
60Aplasia/Hypoplasia of the tibia (HP:0005772)2.21094290
61Acanthocytosis (HP:0001927)2.20649561
62Heterotopia (HP:0002282)2.20551148
63Hypolipoproteinemia (HP:0010981)2.19079013
64Cholecystitis (HP:0001082)2.18825198
65Abnormal gallbladder physiology (HP:0012438)2.18825198
66Abnormal hand bone ossification (HP:0010660)2.16455368
67Impulsivity (HP:0100710)2.14346891
68Xanthomatosis (HP:0000991)2.14255167
69Midline defect of the nose (HP:0004122)2.13906158
70Abnormality of the alveolar ridges (HP:0006477)2.09272130
71Embryonal renal neoplasm (HP:0011794)2.09157059
72Enlarged kidneys (HP:0000105)2.06191579
73Gonadotropin excess (HP:0000837)2.06075802
74Abnormal foot bone ossification (HP:0010675)2.04801981
75Anterior segment dysgenesis (HP:0007700)2.03851652
76Abnormality of the fovea (HP:0000493)2.03155626
77Pancreatic islet-cell hyperplasia (HP:0004510)2.02209473
78Oligodactyly (hands) (HP:0001180)1.97938652
79Abnormal ciliary motility (HP:0012262)1.97073250
80Steatorrhea (HP:0002570)1.96974428
81Abnormality of the nasal septum (HP:0000419)1.96272302
82Rhinitis (HP:0012384)1.95793462
83Abnormal biliary tract physiology (HP:0012439)1.95230745
84Bile duct proliferation (HP:0001408)1.95230745
85Abnormality of calcium-phosphate metabolism (HP:0100530)1.89742048
86Abnormality of the renal cortex (HP:0011035)1.88881682
87Malnutrition (HP:0004395)1.88302826
88Aplasia/Hypoplasia of the tongue (HP:0010295)1.87987729
89Skin pits (HP:0100276)1.86233379
90Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.86145747
91Bifid tongue (HP:0010297)1.85282269
92Renal cortical cysts (HP:0000803)1.83650640
93Abnormal respiratory motile cilium physiology (HP:0012261)1.83309368
94Asymmetry of the thorax (HP:0001555)1.82635859
95Abnormality of the labia minora (HP:0012880)1.82260165
96Meckel diverticulum (HP:0002245)1.79918441
97Abnormal ossification of hand bones (HP:0005921)1.78098426
98Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77556333
99Hypokinesia (HP:0002375)1.77367824
100Abnormality of the ileum (HP:0001549)1.76572111

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.48000139
2NEK62.88138260
3ARAF2.83292170
4MAP3K132.82033513
5FGFR22.77345367
6FGFR32.70809652
7LMTK22.68906342
8STK392.66581567
9FGFR42.65600490
10LATS12.47066488
11CDK122.38067307
12WNK42.31756134
13STK242.28036106
14EIF2AK32.20777180
15PIK3CA2.16069782
16MAPKAPK32.08503930
17CDK91.99775483
18EPHA21.97713898
19MET1.92423157
20NUAK11.75519477
21TTK1.54634857
22FRK1.53119256
23PRKCI1.47587748
24STK31.47083370
25TAOK31.45396051
26CDK71.39324796
27OXSR11.35502570
28STK38L1.32793641
29MST41.30768499
30AURKA1.29886803
31FGFR11.27396190
32BRAF1.23311893
33MELK1.20615632
34MAP3K121.18574885
35TRIM281.09529343
36BMPR1B1.08619462
37NTRK21.06844043
38MAPK151.05202930
39AKT30.99749840
40TYRO30.97729011
41NEK90.97365561
42CDK80.96914510
43RAF10.95638326
44RPS6KB20.94011726
45GRK10.93698361
46EIF2AK10.92715107
47WNK10.83004206
48ICK0.82524640
49PLK10.80694205
50EEF2K0.79213400
51TRPM70.77161439
52CSNK1E0.76488864
53LATS20.76094411
54KSR20.75436420
55PRKAA20.75223641
56WNK30.75206372
57NTRK30.73030820
58CHUK0.72978000
59BRSK20.72547602
60EPHA40.72540130
61CSNK1D0.71948101
62PLK30.68233714
63PTK20.66266929
64PRKCZ0.65223742
65ZAK0.64125272
66PKN20.63753058
67BRSK10.62484970
68FER0.60907085
69PDPK10.60776563
70RPS6KB10.58269156
71ATM0.55434339
72ACVR1B0.55306277
73MTOR0.55287491
74TNIK0.54489138
75RET0.52795470
76NEK20.52607885
77PRKAA10.52432366
78PDK10.49866533
79PRKG10.49777754
80MAPK110.48580378
81MOS0.47714642
82MAP3K20.47226725
83STK380.46309389
84MUSK0.45944986
85PNCK0.45777093
86PRKCE0.45673401
87CSNK1G10.44650663
88CDK20.42882259
89CHEK10.41369066
90PRKACB0.40787419
91CDK10.40216083
92DMPK0.38829747
93MAP2K10.37982523
94AURKB0.35595995
95VRK10.35504700
96NLK0.35170605
97MAP3K40.34586186
98BRD40.34506883
99CAMK1G0.31264524
100CAMK1D0.29203174

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046103.84348794
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.64944334
3Basal transcription factors_Homo sapiens_hsa030222.77245867
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.71798278
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.64443275
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.30812785
7ABC transporters_Homo sapiens_hsa020102.13974972
8Vitamin digestion and absorption_Homo sapiens_hsa049772.13830575
9Fat digestion and absorption_Homo sapiens_hsa049752.01138679
10Bile secretion_Homo sapiens_hsa049762.00839950
11Caffeine metabolism_Homo sapiens_hsa002321.98710509
12Steroid biosynthesis_Homo sapiens_hsa001001.95283188
13Histidine metabolism_Homo sapiens_hsa003401.81842526
14Butanoate metabolism_Homo sapiens_hsa006501.81346813
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.76668786
16Vitamin B6 metabolism_Homo sapiens_hsa007501.70325025
17Ovarian steroidogenesis_Homo sapiens_hsa049131.66113923
18Circadian rhythm_Homo sapiens_hsa047101.63776765
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60223599
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43819102
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43093654
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.42499102
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41192833
24Fatty acid biosynthesis_Homo sapiens_hsa000611.38658019
25Arginine biosynthesis_Homo sapiens_hsa002201.38039682
26Propanoate metabolism_Homo sapiens_hsa006401.35134601
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29522779
28RNA degradation_Homo sapiens_hsa030181.28266466
29Cell cycle_Homo sapiens_hsa041101.28173145
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.28010414
31Phenylalanine metabolism_Homo sapiens_hsa003601.26612003
32Fatty acid degradation_Homo sapiens_hsa000711.24144475
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24066791
34Retinol metabolism_Homo sapiens_hsa008301.21429209
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.19963639
36Dorso-ventral axis formation_Homo sapiens_hsa043201.19678668
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19566293
38Oocyte meiosis_Homo sapiens_hsa041141.19218177
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.18727883
40Chemical carcinogenesis_Homo sapiens_hsa052041.18096962
41Folate biosynthesis_Homo sapiens_hsa007901.16836978
42Fatty acid elongation_Homo sapiens_hsa000621.09982964
43Arginine and proline metabolism_Homo sapiens_hsa003301.09499166
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08405974
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08359525
46Starch and sucrose metabolism_Homo sapiens_hsa005001.06889946
47PPAR signaling pathway_Homo sapiens_hsa033201.03603934
48Fatty acid metabolism_Homo sapiens_hsa012121.01950744
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98994735
50Thyroid hormone synthesis_Homo sapiens_hsa049180.95152303
51Thyroid cancer_Homo sapiens_hsa052160.90233797
52Sphingolipid metabolism_Homo sapiens_hsa006000.90101236
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89353889
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88594966
55Fanconi anemia pathway_Homo sapiens_hsa034600.87485261
56Tyrosine metabolism_Homo sapiens_hsa003500.83437343
57Peroxisome_Homo sapiens_hsa041460.80244859
58Phototransduction_Homo sapiens_hsa047440.77067675
59Nitrogen metabolism_Homo sapiens_hsa009100.75371117
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74790620
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71395961
62Selenocompound metabolism_Homo sapiens_hsa004500.70940392
63Nucleotide excision repair_Homo sapiens_hsa034200.70150196
64Tight junction_Homo sapiens_hsa045300.69550688
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67014027
66N-Glycan biosynthesis_Homo sapiens_hsa005100.66751672
67TGF-beta signaling pathway_Homo sapiens_hsa043500.66699513
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.66451302
69Inositol phosphate metabolism_Homo sapiens_hsa005620.65024699
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.63699233
71Lysine degradation_Homo sapiens_hsa003100.63071835
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62804062
73Adherens junction_Homo sapiens_hsa045200.60016852
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59495080
75beta-Alanine metabolism_Homo sapiens_hsa004100.56967462
76Glycerolipid metabolism_Homo sapiens_hsa005610.55317930
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54554984
78Mismatch repair_Homo sapiens_hsa034300.53585748
79Renin-angiotensin system_Homo sapiens_hsa046140.53406157
80Homologous recombination_Homo sapiens_hsa034400.52780494
81Hippo signaling pathway_Homo sapiens_hsa043900.52035290
82RNA transport_Homo sapiens_hsa030130.49872834
83p53 signaling pathway_Homo sapiens_hsa041150.47713311
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47122602
85Tryptophan metabolism_Homo sapiens_hsa003800.46568039
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45840724
87Ether lipid metabolism_Homo sapiens_hsa005650.44443280
88Protein export_Homo sapiens_hsa030600.43170945
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42218467
90Olfactory transduction_Homo sapiens_hsa047400.40357871
91Metabolic pathways_Homo sapiens_hsa011000.40141622
92Protein digestion and absorption_Homo sapiens_hsa049740.39904555
93Pancreatic secretion_Homo sapiens_hsa049720.39849581
94Sulfur metabolism_Homo sapiens_hsa009200.39686343
95mRNA surveillance pathway_Homo sapiens_hsa030150.39667277
96Wnt signaling pathway_Homo sapiens_hsa043100.37976817
97Vibrio cholerae infection_Homo sapiens_hsa051100.37596162
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.36329594
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35649261
100mTOR signaling pathway_Homo sapiens_hsa041500.34739573

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