DCAF7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signaling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.56041171
2synaptic vesicle maturation (GO:0016188)5.36818367
3response to pheromone (GO:0019236)5.06267250
4mitotic chromosome condensation (GO:0007076)5.03679670
5layer formation in cerebral cortex (GO:0021819)5.02426213
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.95621905
7sister chromatid segregation (GO:0000819)4.94218006
8locomotory exploration behavior (GO:0035641)4.81813610
9mitotic sister chromatid segregation (GO:0000070)4.78478245
10synaptic vesicle exocytosis (GO:0016079)4.73770936
11DNA unwinding involved in DNA replication (GO:0006268)4.73074303
12DNA topological change (GO:0006265)4.43127888
13dendritic spine morphogenesis (GO:0060997)4.31628964
14regulation of synaptic vesicle exocytosis (GO:2000300)4.27142253
15regulation of synapse structural plasticity (GO:0051823)4.21402051
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.17711208
17protein localization to chromosome, centromeric region (GO:0071459)4.13688828
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.08893737
19glutamate secretion (GO:0014047)4.06540448
20exploration behavior (GO:0035640)4.05895539
21vocalization behavior (GO:0071625)4.05276586
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.02136642
23positive regulation of synapse maturation (GO:0090129)4.00100638
24mitotic sister chromatid cohesion (GO:0007064)3.99924771
25protein localization to synapse (GO:0035418)3.99762497
26nucleosome disassembly (GO:0006337)3.97710918
27protein-DNA complex disassembly (GO:0032986)3.97710918
28sodium ion export (GO:0071436)3.94282044
29regulation of glutamate receptor signaling pathway (GO:1900449)3.84674772
30mitotic metaphase plate congression (GO:0007080)3.82649753
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.78482287
32regulation of synaptic vesicle transport (GO:1902803)3.77054377
33protein localization to kinetochore (GO:0034501)3.69238342
34regulation of RNA export from nucleus (GO:0046831)3.63026245
35negative regulation of microtubule polymerization (GO:0031115)3.61376736
36microtubule depolymerization (GO:0007019)3.59649659
37regulation of spindle organization (GO:0090224)3.58893163
38neurotransmitter secretion (GO:0007269)3.58001100
39dendrite morphogenesis (GO:0048813)3.57037125
40pyrimidine nucleobase catabolic process (GO:0006208)3.50527536
41establishment of nucleus localization (GO:0040023)3.49846604
42neuron cell-cell adhesion (GO:0007158)3.45623230
43activation of protein kinase A activity (GO:0034199)3.44714187
44regulation of mitotic spindle organization (GO:0060236)3.38185854
45protein localization to chromosome (GO:0034502)3.34492293
46positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.33925386
47cerebellar Purkinje cell layer development (GO:0021680)3.32789661
48cellular potassium ion homeostasis (GO:0030007)3.32755014
49regulation of translational fidelity (GO:0006450)3.31609354
50spliceosomal tri-snRNP complex assembly (GO:0000244)3.30952334
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.30630858
52regulation of long-term neuronal synaptic plasticity (GO:0048169)3.30602449
53RNA localization (GO:0006403)3.29919049
54regulation of NFAT protein import into nucleus (GO:0051532)3.29012299
55axonal fasciculation (GO:0007413)3.28744288
56metaphase plate congression (GO:0051310)3.27334782
57regulation of neuronal synaptic plasticity (GO:0048168)3.24564404
58auditory behavior (GO:0031223)3.24417429
59cell communication by electrical coupling (GO:0010644)3.24084288
60chromosome condensation (GO:0030261)3.22231626
61nuclear pore complex assembly (GO:0051292)3.21572910
62regulation of ARF protein signal transduction (GO:0032012)3.19961400
63neuron recognition (GO:0008038)3.19874795
64innervation (GO:0060384)3.18521300
65positive regulation of synaptic transmission, GABAergic (GO:0032230)3.13165796
66proline transport (GO:0015824)3.11748446
67establishment of mitotic spindle localization (GO:0040001)3.11060798
68establishment of chromosome localization (GO:0051303)3.09456926
69synaptic vesicle endocytosis (GO:0048488)3.04690176
70peptidyl-arginine omega-N-methylation (GO:0035247)3.04644996
71COPI coating of Golgi vesicle (GO:0048205)3.03102259
72Golgi transport vesicle coating (GO:0048200)3.03102259
73cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.01898482
74central nervous system projection neuron axonogenesis (GO:0021952)3.01130639
75positive regulation of dendritic spine morphogenesis (GO:0061003)3.00371880
76clathrin coat assembly (GO:0048268)2.99731772
77response to auditory stimulus (GO:0010996)2.98160488
78cell migration in hindbrain (GO:0021535)2.97631031
79dendritic spine organization (GO:0097061)2.97445769
80establishment of mitochondrion localization (GO:0051654)2.96640424
81cerebellar Purkinje cell differentiation (GO:0021702)2.96627160
82mitotic spindle organization (GO:0007052)2.95447653
83nuclear pore organization (GO:0006999)2.95240715
84regulation of sister chromatid cohesion (GO:0007063)2.90072351
85mitotic nuclear envelope disassembly (GO:0007077)2.89329220
86cerebellum development (GO:0021549)2.87474882
87vesicle transport along microtubule (GO:0047496)2.84639771
88ganglion development (GO:0061548)2.82848303
89ionotropic glutamate receptor signaling pathway (GO:0035235)2.82573641
90establishment of spindle localization (GO:0051293)2.81750258
91neuromuscular process controlling balance (GO:0050885)2.80593723
92axon cargo transport (GO:0008088)2.80303693
93protein localization to microtubule (GO:0035372)2.80155284
94G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.79616334
95nuclear envelope disassembly (GO:0051081)2.79517451
96membrane disassembly (GO:0030397)2.79517451
97stress granule assembly (GO:0034063)2.79257221
98peptidyl-arginine methylation (GO:0018216)2.78773240
99peptidyl-arginine N-methylation (GO:0035246)2.78773240
100chromosome segregation (GO:0007059)2.77827651
101regulation of nucleobase-containing compound transport (GO:0032239)2.76397636
102RNA stabilization (GO:0043489)2.76109316
103mRNA stabilization (GO:0048255)2.76109316
104intracellular estrogen receptor signaling pathway (GO:0030520)2.75530439
105positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.74986321
106dopamine receptor signaling pathway (GO:0007212)2.74584470
107ATP-dependent chromatin remodeling (GO:0043044)2.74059778
108nucleobase catabolic process (GO:0046113)2.73732078
109regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.73371115
110negative regulation of histone methylation (GO:0031061)2.73329612
111mitochondrion transport along microtubule (GO:0047497)2.73274588
112establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.73274588
113histone H2A acetylation (GO:0043968)2.71305313
114regulation of calcium ion-dependent exocytosis (GO:0017158)2.71078558
115DNA ligation (GO:0006266)2.70413524
116establishment of integrated proviral latency (GO:0075713)2.69914746
117positive regulation of RNA splicing (GO:0033120)2.68345315
118neurotransmitter transport (GO:0006836)2.68162040
119organelle transport along microtubule (GO:0072384)2.68006670
120establishment of spindle orientation (GO:0051294)2.67202833
121long-term memory (GO:0007616)2.66814543
122regulation of synapse maturation (GO:0090128)2.66410896
123prepulse inhibition (GO:0060134)2.65197241
124DNA packaging (GO:0006323)2.64474478
125adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.63984001
126neurotransmitter-gated ion channel clustering (GO:0072578)2.63562522
127planar cell polarity pathway involved in neural tube closure (GO:0090179)2.63252929
128synaptic transmission, glutamatergic (GO:0035249)2.62286891
129DNA strand elongation (GO:0022616)2.61640704
130regulation of vesicle fusion (GO:0031338)2.61303109
131positive regulation of membrane potential (GO:0045838)2.60407684
132DNA strand elongation involved in DNA replication (GO:0006271)2.59740351
133synapse assembly (GO:0007416)2.58496871
134cytoskeletal anchoring at plasma membrane (GO:0007016)2.57178823
135regulation of dendritic spine morphogenesis (GO:0061001)2.57080181
136intraspecies interaction between organisms (GO:0051703)2.56769903
137social behavior (GO:0035176)2.56769903
138mitotic cytokinesis (GO:0000281)2.54401747
139regulation of synaptic plasticity (GO:0048167)2.54181883
140negative regulation of cytosolic calcium ion concentration (GO:0051481)2.54092766
141positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.53880749
142mating behavior (GO:0007617)2.53109678
143synapse organization (GO:0050808)2.52889435
144establishment of mitotic spindle orientation (GO:0000132)2.52779362
145regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.52599236
146establishment of synaptic vesicle localization (GO:0097480)2.52268618
147synaptic vesicle transport (GO:0048489)2.52268618
148convergent extension (GO:0060026)2.51940480
149glutamate receptor signaling pathway (GO:0007215)2.51027551
150negative regulation of microtubule polymerization or depolymerization (GO:0031111)2.50910301
151spindle organization (GO:0007051)2.50400017
152positive regulation of DNA-dependent DNA replication (GO:2000105)2.49399374
153membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.48952211
154regulation of postsynaptic membrane potential (GO:0060078)2.48477336
155mechanosensory behavior (GO:0007638)2.47960543
156sympathetic nervous system development (GO:0048485)2.47881029
157regulation of chromosome segregation (GO:0051983)2.46695117
158detection of calcium ion (GO:0005513)2.46559241
159regulation of excitatory postsynaptic membrane potential (GO:0060079)2.46099087
160membrane hyperpolarization (GO:0060081)2.45936292
161neuron projection extension involved in neuron projection guidance (GO:1902284)2.45694519
162axon extension involved in axon guidance (GO:0048846)2.45694519
163regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.45364560
164neuron-neuron synaptic transmission (GO:0007270)2.44871565
165positive regulation of dendritic spine development (GO:0060999)2.43321207
166membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.42994222
167axon extension (GO:0048675)2.42890790
168regulation of neurotransmitter secretion (GO:0046928)2.42182781
169positive regulation of chromosome segregation (GO:0051984)2.40991975
170DNA duplex unwinding (GO:0032508)2.40898682
171regulation of mammary gland epithelial cell proliferation (GO:0033599)2.40506505
172V(D)J recombination (GO:0033151)2.40158329
173regulation of neurotransmitter levels (GO:0001505)2.40120481
174DNA conformation change (GO:0071103)2.39602935
175regulation of histone H3-K4 methylation (GO:0051569)2.38085359
176spindle checkpoint (GO:0031577)2.36498993
177retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.36058471
178camera-type eye morphogenesis (GO:0048593)2.35445287
179kinetochore organization (GO:0051383)2.35326261
180postsynaptic membrane organization (GO:0001941)2.34466117
181histone arginine methylation (GO:0034969)2.34361484
182dosage compensation (GO:0007549)2.34131258
183nuclear envelope organization (GO:0006998)2.33812866
184attachment of spindle microtubules to kinetochore (GO:0008608)2.32341843
185cytoskeleton-dependent cytokinesis (GO:0061640)2.31912789
186ectodermal placode formation (GO:0060788)2.31266809
187retinal ganglion cell axon guidance (GO:0031290)2.31223253

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.84030350
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.60884518
3EZH2_22144423_ChIP-Seq_EOC_Human5.50872078
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.87679471
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.63635012
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.62915394
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.24100346
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.86318526
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.81214039
10REST_21632747_ChIP-Seq_MESCs_Mouse2.71990453
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.69745077
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.60651127
13DROSHA_22980978_ChIP-Seq_HELA_Human2.60540784
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.52008521
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.46330998
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.45343708
17AR_21909140_ChIP-Seq_LNCAP_Human2.42866275
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42163146
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.35625197
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.35427306
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32720182
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29042114
23CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.26412307
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.23805383
25RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18218983
26EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18218983
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17411132
28* XRN2_22483619_ChIP-Seq_HELA_Human2.17283606
29STAT6_21828071_ChIP-Seq_BEAS2B_Human2.13319089
30SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13185158
31JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11868333
32EZH2_27294783_Chip-Seq_ESCs_Mouse2.09543553
33GBX2_23144817_ChIP-Seq_PC3_Human2.08742932
34EZH2_27304074_Chip-Seq_ESCs_Mouse2.08460448
35RNF2_27304074_Chip-Seq_ESCs_Mouse2.06871994
36MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06168690
37TP63_19390658_ChIP-ChIP_HaCaT_Human2.02321907
38ZFP281_18757296_ChIP-ChIP_E14_Mouse2.02119514
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.01558966
40THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01187496
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01158136
42PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.95603210
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.94245900
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93528452
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88345040
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87303624
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85885706
48ZNF274_21170338_ChIP-Seq_K562_Hela1.84910877
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83079326
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77149099
51TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.76528805
52KDM2B_26808549_Chip-Seq_K562_Human1.75657706
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.75150518
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74301215
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72597565
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.70861251
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70517126
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68510312
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67985608
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67628056
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.67241844
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.64956142
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64572647
64EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.64401809
65MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63430428
66* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.59623232
67KDM2B_26808549_Chip-Seq_DND41_Human1.56331010
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54602935
69KDM5A_27292631_Chip-Seq_BREAST_Human1.52933684
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.51258155
71CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.50872655
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50462770
73ZFP281_27345836_Chip-Seq_ESCs_Mouse1.49695053
74KDM2B_26808549_Chip-Seq_JURKAT_Human1.48755313
75EGR1_19374776_ChIP-ChIP_THP-1_Human1.48730751
76TTF2_22483619_ChIP-Seq_HELA_Human1.47235512
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47036763
78OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.46277858
79AR_21572438_ChIP-Seq_LNCaP_Human1.46157107
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44928295
81DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44698856
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42226000
83EED_16625203_ChIP-ChIP_MESCs_Mouse1.41783703
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.39893174
85CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37902048
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37761498
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36828891
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36788769
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36759855
90GABP_19822575_ChIP-Seq_HepG2_Human1.36375255
91AR_19668381_ChIP-Seq_PC3_Human1.35642760
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34086305
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32709484
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32325075
95MYC_22102868_ChIP-Seq_BL_Human1.32268434
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31483593
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29080127
98WT1_19549856_ChIP-ChIP_CCG9911_Human1.28647744
99NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27757057
100ZNF263_19887448_ChIP-Seq_K562_Human1.27093752
101CIITA_25753668_ChIP-Seq_RAJI_Human1.25605632
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25227706
103SOX2_21211035_ChIP-Seq_LN229_Gbm1.25074090
104DCP1A_22483619_ChIP-Seq_HELA_Human1.24489669
105CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24447199
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23944809
107YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23774179
108EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23271309
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22556376
110KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20279694
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19234643
112YY1_21170310_ChIP-Seq_MESCs_Mouse1.18887125
113PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17862139
114RING1B_27294783_Chip-Seq_NPCs_Mouse1.17139111
115* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16229153
116ELK4_26923725_Chip-Seq_MESODERM_Mouse1.15809883
117KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12720758
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12068847
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11734799
120TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.11601198
121SMAD_19615063_ChIP-ChIP_OVARY_Human1.11552597
122TCF7_22412390_ChIP-Seq_EML_Mouse1.09523817
123SMAD3_21741376_ChIP-Seq_ESCs_Human1.09512503
124TET1_21490601_ChIP-Seq_MESCs_Mouse1.08721028
125SALL1_21062744_ChIP-ChIP_HESCs_Human1.07967282
126LXR_22292898_ChIP-Seq_THP-1_Human1.07318534
127CHD1_26751641_Chip-Seq_LNCaP_Human1.07286165
128ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07155714
129MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06861807
130ETS1_20019798_ChIP-Seq_JURKAT_Human1.06006590
131KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05414113
132ERG_21242973_ChIP-ChIP_JURKAT_Human1.05201546
133P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05174133
134PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04158817
135DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03893575
136CBX2_27304074_Chip-Seq_ESCs_Mouse1.03483237
137CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02584245
138IGF1R_20145208_ChIP-Seq_DFB_Human1.02488565
139ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02425689
140* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02228211
141TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01785610
142NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01730013
143E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00695918
144RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00622880
145CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00309843
146JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.00141123
147SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99483769
148SMAD4_21799915_ChIP-Seq_A2780_Human0.99055835
149SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97179242
150SMC4_20622854_ChIP-Seq_HELA_Human0.96754223
151* STAT3_23295773_ChIP-Seq_U87_Human0.94937073
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94332949
153RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93992780
154EST1_17652178_ChIP-ChIP_JURKAT_Human0.93750055
155SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92373152
156SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91944334
157SMAD4_21741376_ChIP-Seq_HESCs_Human0.91247983
158SOX17_20123909_ChIP-Seq_XEN_Mouse0.91200889
159E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91190727
160ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90167164
161TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.90032274
162MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89658572
163KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89620886
164SOX2_16153702_ChIP-ChIP_HESCs_Human0.89602121
165POU5F1_16518401_ChIP-PET_MESCs_Mouse0.87133969
166POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86536086
167TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86536086
168* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85837189
169SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85382624
170PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.84323980
171CLOCK_20551151_ChIP-Seq_293T_Human0.83864025
172HIF1A_21447827_ChIP-Seq_MCF-7_Human0.83312413
173PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82428442
174CREB1_26743006_Chip-Seq_LNCaP_Human0.82369212
175RNF2_27304074_Chip-Seq_NSC_Mouse0.82147400
176SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81985484
177CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81920127
178GATA1_26923725_Chip-Seq_HPCs_Mouse0.81887099

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.66628648
2MP0000566_synostosis4.16928477
3MP0003635_abnormal_synaptic_transmissio3.48693381
4MP0003880_abnormal_central_pattern3.18910963
5MP0005423_abnormal_somatic_nervous3.16631090
6MP0003283_abnormal_digestive_organ2.98680002
7MP0003693_abnormal_embryo_hatching2.92307749
8MP0004270_analgesia2.89728190
9MP0002063_abnormal_learning/memory/cond2.83483786
10MP0008961_abnormal_basal_metabolism2.77482662
11MP0002909_abnormal_adrenal_gland2.62320319
12MP0003122_maternal_imprinting2.61950614
13MP0009780_abnormal_chondrocyte_physiolo2.46275847
14MP0003111_abnormal_nucleus_morphology2.43814956
15MP0010094_abnormal_chromosome_stability2.36141010
16MP0000569_abnormal_digit_pigmentation2.31281591
17MP0002064_seizures2.26025553
18MP0009745_abnormal_behavioral_response2.18825466
19MP0003077_abnormal_cell_cycle2.14056692
20MP0002572_abnormal_emotion/affect_behav2.10094681
21MP0004811_abnormal_neuron_physiology2.09307228
22MP0000778_abnormal_nervous_system2.07727564
23MP0002184_abnormal_innervation2.01524048
24MP0004233_abnormal_muscle_weight1.91982666
25MP0008932_abnormal_embryonic_tissue1.89005068
26MP0000013_abnormal_adipose_tissue1.87124538
27MP0002734_abnormal_mechanical_nocicepti1.86977785
28MP0008057_abnormal_DNA_replication1.77329008
29MP0009046_muscle_twitch1.73087171
30MP0002557_abnormal_social/conspecific_i1.70838053
31MP0000955_abnormal_spinal_cord1.69526214
32MP0006276_abnormal_autonomic_nervous1.69497348
33MP0003183_abnormal_peptide_metabolism1.68635698
34MP0003329_amyloid_beta_deposits1.68447450
35MP0002009_preneoplasia1.66943600
36MP0010030_abnormal_orbit_morphology1.66885902
37MP0005645_abnormal_hypothalamus_physiol1.66851328
38MP0001486_abnormal_startle_reflex1.66013600
39MP0008789_abnormal_olfactory_epithelium1.65268637
40MP0002733_abnormal_thermal_nociception1.63457954
41MP0003942_abnormal_urinary_system1.63034455
42MP0001968_abnormal_touch/_nociception1.62387270
43MP0003315_abnormal_perineum_morphology1.61491956
44MP0004957_abnormal_blastocyst_morpholog1.60230081
45MP0004858_abnormal_nervous_system1.58982202
46MP0001730_embryonic_growth_arrest1.57803586
47MP0003121_genomic_imprinting1.56221692
48MP0008569_lethality_at_weaning1.55388195
49MP0005409_darkened_coat_color1.51863254
50MP0003938_abnormal_ear_development1.50174920
51MP0003937_abnormal_limbs/digits/tail_de1.46771622
52MP0001984_abnormal_olfaction1.46177858
53MP0001502_abnormal_circadian_rhythm1.44663502
54MP0002882_abnormal_neuron_morphology1.42516166
55MP0002085_abnormal_embryonic_tissue1.42484015
56MP0002234_abnormal_pharynx_morphology1.42307631
57MP0008058_abnormal_DNA_repair1.42141972
58MP0002084_abnormal_developmental_patter1.41742197
59MP0002272_abnormal_nervous_system1.41062262
60MP0002067_abnormal_sensory_capabilities1.40301677
61MP0001970_abnormal_pain_threshold1.40236554
62MP0003787_abnormal_imprinting1.40011039
63MP0002697_abnormal_eye_size1.39812133
64MP0002249_abnormal_larynx_morphology1.38947430
65MP0010386_abnormal_urinary_bladder1.38901710
66MP0002938_white_spotting1.37043912
67MP0005380_embryogenesis_phenotype1.36902846
68MP0001672_abnormal_embryogenesis/_devel1.36902846
69MP0000350_abnormal_cell_proliferation1.36074149
70MP0002152_abnormal_brain_morphology1.35051533
71MP0004264_abnormal_extraembryonic_tissu1.34564761
72MP0002653_abnormal_ependyma_morphology1.34505331
73MP0001286_abnormal_eye_development1.33873294
74MP0004924_abnormal_behavior1.33566366
75MP0005386_behavior/neurological_phenoty1.33566366
76MP0006072_abnormal_retinal_apoptosis1.33179374
77MP0001440_abnormal_grooming_behavior1.32339058
78MP0000631_abnormal_neuroendocrine_gland1.31785947
79MP0004197_abnormal_fetal_growth/weight/1.30295711
80MP0005076_abnormal_cell_differentiation1.30032960
81MP0001697_abnormal_embryo_size1.29320457
82MP0003935_abnormal_craniofacial_develop1.28433684
83MP0005187_abnormal_penis_morphology1.27571469
84MP0001293_anophthalmia1.26422349
85MP0009672_abnormal_birth_weight1.25960997
86MP0003172_abnormal_lysosome_physiology1.25022502
87MP0003385_abnormal_body_wall1.23724425
88MP0002092_abnormal_eye_morphology1.23064070
89MP0003984_embryonic_growth_retardation1.22824341
90MP0002233_abnormal_nose_morphology1.21607045
91MP0000049_abnormal_middle_ear1.21319651
92MP0001529_abnormal_vocalization1.20584947
93MP0003567_abnormal_fetal_cardiomyocyte1.20502459
94MP0002080_prenatal_lethality1.18993675
95MP0002088_abnormal_embryonic_growth/wei1.18972133
96MP0002735_abnormal_chemical_nociception1.18853780
97MP0005646_abnormal_pituitary_gland1.17386325
98MP0003879_abnormal_hair_cell1.15226741
99MP0002066_abnormal_motor_capabilities/c1.13617511
100MP0002116_abnormal_craniofacial_bone1.11696381
101MP0000537_abnormal_urethra_morphology1.11595556
102MP0002638_abnormal_pupillary_reflex1.10862711
103MP0003861_abnormal_nervous_system1.10146140
104MP0003755_abnormal_palate_morphology1.08670868
105MP0005499_abnormal_olfactory_system1.08298501
106MP0005394_taste/olfaction_phenotype1.08298501
107MP0001346_abnormal_lacrimal_gland1.06992703
108MP0002090_abnormal_vision1.05355583
109MP0000003_abnormal_adipose_tissue1.03047489
110MP0000462_abnormal_digestive_system1.01970938
111MP0006292_abnormal_olfactory_placode1.01879211
112MP0002822_catalepsy1.00532773
113MP0002069_abnormal_eating/drinking_beha0.98665829
114MP0004885_abnormal_endolymph0.97825543
115MP0005551_abnormal_eye_electrophysiolog0.97111449
116MP0009703_decreased_birth_body0.96785129
117MP0002089_abnormal_postnatal_growth/wei0.96529914
118MP0005248_abnormal_Harderian_gland0.96519350
119MP0003890_abnormal_embryonic-extraembry0.96230112
120MP0001944_abnormal_pancreas_morphology0.96139075
121MP0001299_abnormal_eye_distance/0.95266088
122MP0004133_heterotaxia0.94789324
123MP0000428_abnormal_craniofacial_morphol0.93873779
124MP0010234_abnormal_vibrissa_follicle0.91933314
125MP0009053_abnormal_anal_canal0.91255369
126MP0003718_maternal_effect0.91008314
127MP0003119_abnormal_digestive_system0.89472124
128MP0003633_abnormal_nervous_system0.88602533
129MP0001501_abnormal_sleep_pattern0.87429913
130MP0002086_abnormal_extraembryonic_tissu0.86594606
131MP0005623_abnormal_meninges_morphology0.85341675
132MP0002098_abnormal_vibrissa_morphology0.85165430
133MP0008007_abnormal_cellular_replicative0.82812319
134MP0002111_abnormal_tail_morphology0.82528419
135MP0003634_abnormal_glial_cell0.81918369
136MP0002736_abnormal_nociception_after0.79522206
137MP0001270_distended_abdomen0.77606076
138MP0003943_abnormal_hepatobiliary_system0.76472691
139MP0000313_abnormal_cell_death0.75851430
140MP0000647_abnormal_sebaceous_gland0.75673473
141MP0002114_abnormal_axial_skeleton0.74729582
142MP0000534_abnormal_ureter_morphology0.73985789
143MP0002081_perinatal_lethality0.70168312
144MP0004145_abnormal_muscle_electrophysio0.70060697
145MP0003631_nervous_system_phenotype0.69811926
146MP0002752_abnormal_somatic_nervous0.68944637
147MP0002751_abnormal_autonomic_nervous0.68478144
148MP0002877_abnormal_melanocyte_morpholog0.68363557
149MP0005253_abnormal_eye_physiology0.68192210
150MP0003303_peritoneal_inflammation0.67986849
151MP0003115_abnormal_respiratory_system0.67260407
152MP0000604_amyloidosis0.67138714
153MP0003123_paternal_imprinting0.67022634
154MP0001943_abnormal_respiration0.66554264
155MP0001348_abnormal_lacrimal_gland0.66251124
156MP0004085_abnormal_heartbeat0.64900857
157MP0010769_abnormal_survival0.64883253
158MP0002693_abnormal_pancreas_physiology0.64526928
159MP0003300_gastrointestinal_ulcer0.64221245
160MP0002082_postnatal_lethality0.64043283
161MP0010770_preweaning_lethality0.64043283

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)5.53274908
2Visual hallucinations (HP:0002367)4.53888284
3Mutism (HP:0002300)3.63414874
4Hyperacusis (HP:0010780)3.63055551
5Papilledema (HP:0001085)3.52578977
6Focal seizures (HP:0007359)3.49448322
7Focal motor seizures (HP:0011153)3.46500642
8Myokymia (HP:0002411)3.40454031
9Insomnia (HP:0100785)3.22973753
10Agitation (HP:0000713)3.16695983
11Ankle clonus (HP:0011448)3.13265359
12Supranuclear gaze palsy (HP:0000605)3.12534494
13High anterior hairline (HP:0009890)2.99989685
14Depression (HP:0000716)2.99470665
15Pointed chin (HP:0000307)2.93291976
16Macroorchidism (HP:0000053)2.86199812
17Trigonocephaly (HP:0000243)2.82513461
18Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.80832133
19Elfin facies (HP:0004428)2.78906765
20Epileptic encephalopathy (HP:0200134)2.76218813
21Amyotrophic lateral sclerosis (HP:0007354)2.73906047
22Progressive cerebellar ataxia (HP:0002073)2.70692951
23Asymmetry of the thorax (HP:0001555)2.60797309
24Neoplasm of the heart (HP:0100544)2.58240370
25Apathy (HP:0000741)2.56031090
26Truncal ataxia (HP:0002078)2.54767382
27Overlapping toe (HP:0001845)2.54172614
28Absence seizures (HP:0002121)2.51089609
29Renal duplication (HP:0000075)2.49676980
30Abnormal gallbladder physiology (HP:0012438)2.47353149
31Cholecystitis (HP:0001082)2.47353149
32Abnormality of the lower motor neuron (HP:0002366)2.44242585
33Genetic anticipation (HP:0003743)2.43184867
34Polyphagia (HP:0002591)2.43148604
3511 pairs of ribs (HP:0000878)2.42515677
36Excessive salivation (HP:0003781)2.42389248
37Drooling (HP:0002307)2.42389248
38Impaired smooth pursuit (HP:0007772)2.42104525
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.41870818
40Overriding aorta (HP:0002623)2.38702314
41Diminished motivation (HP:0000745)2.38504005
42Retinal dysplasia (HP:0007973)2.37822345
43Urinary urgency (HP:0000012)2.32483556
44Failure to thrive in infancy (HP:0001531)2.31898627
45EEG with generalized epileptiform discharges (HP:0011198)2.31397833
46Action tremor (HP:0002345)2.29829706
47Broad distal phalanx of finger (HP:0009836)2.29429452
48Renovascular hypertension (HP:0100817)2.28733313
49Ankyloglossia (HP:0010296)2.27496291
50Obsessive-compulsive behavior (HP:0000722)2.27486141
51Abnormal eating behavior (HP:0100738)2.26719734
52Proximal placement of thumb (HP:0009623)2.24622492
53Hypsarrhythmia (HP:0002521)2.24577327
54Epileptiform EEG discharges (HP:0011182)2.23088885
55Inappropriate behavior (HP:0000719)2.19895548
56Abnormal lung lobation (HP:0002101)2.18602571
57Megalencephaly (HP:0001355)2.18008310
58Deviation of the thumb (HP:0009603)2.17794676
59Shawl scrotum (HP:0000049)2.17478657
60Poor eye contact (HP:0000817)2.17287168
61Chromsome breakage (HP:0040012)2.14424749
62Dialeptic seizures (HP:0011146)2.13025664
63Sacral dimple (HP:0000960)2.10451683
64Generalized hypotonia (HP:0001290)2.10193109
65Abnormality of ocular smooth pursuit (HP:0000617)2.08523077
66Volvulus (HP:0002580)2.06627394
67Flat cornea (HP:0007720)2.06357581
68Generalized tonic-clonic seizures (HP:0002069)2.04659757
69Abnormality of oral frenula (HP:0000190)2.03292046
70Abnormality of chromosome segregation (HP:0002916)2.03199425
71Impaired social interactions (HP:0000735)2.02584241
72Abnormal social behavior (HP:0012433)2.02584241
73Stereotypic behavior (HP:0000733)2.01538665
74Short 4th metacarpal (HP:0010044)2.00867879
75Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.00867879
76Cerebral inclusion bodies (HP:0100314)2.00437864
77Megalocornea (HP:0000485)2.00360365
78Papillary thyroid carcinoma (HP:0002895)2.00081565
79Neuroendocrine neoplasm (HP:0100634)2.00018417
80Hypoventilation (HP:0002791)1.99866723
81Shoulder girdle muscle weakness (HP:0003547)1.99045120
82Urinary bladder sphincter dysfunction (HP:0002839)1.96913433
83Facial hemangioma (HP:0000329)1.96888859
84Missing ribs (HP:0000921)1.96083695
85Open mouth (HP:0000194)1.95605186
86Broad palm (HP:0001169)1.95180996
87Uterine leiomyosarcoma (HP:0002891)1.95100426
88Leiomyosarcoma (HP:0100243)1.95100426
89Neuronal loss in central nervous system (HP:0002529)1.94685875
90Abnormality of the aortic arch (HP:0012303)1.94379577
91Medulloblastoma (HP:0002885)1.94210760
92Increased nuchal translucency (HP:0010880)1.93924320
93Long palpebral fissure (HP:0000637)1.93712847
94Oligodactyly (HP:0012165)1.93096977
95Hypoplasia of the brainstem (HP:0002365)1.92957077
96Aplasia/Hypoplasia of the brainstem (HP:0007362)1.92957077
97Impaired vibration sensation in the lower limbs (HP:0002166)1.92952257
98Bowel diverticulosis (HP:0005222)1.92916118
99Patellar aplasia (HP:0006443)1.92391941
100Coarctation of aorta (HP:0001680)1.91697322
101Postural instability (HP:0002172)1.90623660
102Termporal pattern (HP:0011008)1.90565978
103Insidious onset (HP:0003587)1.90565978
104Spastic gait (HP:0002064)1.90065436
105Hemiplegia (HP:0002301)1.88557843
106Striae distensae (HP:0001065)1.87620256
107Deep palmar crease (HP:0006191)1.87158899
108Abnormality of the phalanges of the hallux (HP:0010057)1.86166858
109Abnormality of the distal phalanx of the thumb (HP:0009617)1.85805452
110Lissencephaly (HP:0001339)1.85382342
111Atonic seizures (HP:0010819)1.84842946
112Midline defect of the nose (HP:0004122)1.84174624
113Deep philtrum (HP:0002002)1.84083062
114Patellar dislocation (HP:0002999)1.83747528
115Central scotoma (HP:0000603)1.83266591
116Limb dystonia (HP:0002451)1.83072543
117Torticollis (HP:0000473)1.82881940
118Clonus (HP:0002169)1.82085666
119Pheochromocytoma (HP:0002666)1.82043155
120Heterotopia (HP:0002282)1.81954773
121Astrocytoma (HP:0009592)1.81720099
122Abnormality of the astrocytes (HP:0100707)1.81720099
123Abnormality of glycolysis (HP:0004366)1.81350974
124Rapidly progressive (HP:0003678)1.79967297
125Hemiparesis (HP:0001269)1.79918974
126Anxiety (HP:0000739)1.79220847
127Hypercortisolism (HP:0001578)1.77936535
128Intellectual disability, profound (HP:0002187)1.76800310
129Nephroblastoma (Wilms tumor) (HP:0002667)1.76706477
130Dysdiadochokinesis (HP:0002075)1.76279842
131Abnormality of the diencephalon (HP:0010662)1.76248786
132Aplasia/Hypoplasia of the sternum (HP:0006714)1.75955594
133Thyroid carcinoma (HP:0002890)1.73765289
134Menstrual irregularities (HP:0000858)1.73665137
135Progressive inability to walk (HP:0002505)1.73308541
136Spina bifida occulta (HP:0003298)1.73146274
137Pachygyria (HP:0001302)1.73026617
138Vertebral hypoplasia (HP:0008417)1.72924975
139Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.72924975
140Hepatoblastoma (HP:0002884)1.72865108
141Atrophy/Degeneration involving motor neurons (HP:0007373)1.72827928
142Disinhibition (HP:0000734)1.72581519
143Reticulocytosis (HP:0001923)1.71116486
144Aplasia/Hypoplasia of the patella (HP:0006498)1.70202703
145Febrile seizures (HP:0002373)1.70146320
146Long toe (HP:0010511)1.69520575
147Broad-based gait (HP:0002136)1.69138335
148Neurofibrillary tangles (HP:0002185)1.68709790
149Transitional cell carcinoma of the bladder (HP:0006740)1.67945808
150Abnormality of the parathyroid morphology (HP:0011766)1.66904930
151Spinal canal stenosis (HP:0003416)1.66281305
152Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.65082260
153Bradykinesia (HP:0002067)1.64954321
154Tented upper lip vermilion (HP:0010804)1.64467072
155Attention deficit hyperactivity disorder (HP:0007018)1.63228458
156Diastasis recti (HP:0001540)1.62258638
157Disproportionate tall stature (HP:0001519)1.62168874
158Absent epiphyses (HP:0010577)1.61610871
159Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.61610871
160Myelomeningocele (HP:0002475)1.61366096
161Cafe-au-lait spot (HP:0000957)1.59642838
162Morphological abnormality of the inner ear (HP:0011390)1.59371141
163Abnormality of the carotid arteries (HP:0005344)1.59250327
164Anal stenosis (HP:0002025)1.59195351
165Bicornuate uterus (HP:0000813)1.59070406
166Cerebellar hypoplasia (HP:0001321)1.57654275
167Embryonal renal neoplasm (HP:0011794)1.57528238
168Abnormality of the 4th metacarpal (HP:0010012)1.57154784
169Abnormality of reticulocytes (HP:0004312)1.57103574
170Thick eyebrow (HP:0000574)1.56604821
171Bladder neoplasm (HP:0009725)1.55818497
172Bladder carcinoma (HP:0002862)1.55818497
173Exotropia (HP:0000577)1.55577752
174Capillary hemangiomas (HP:0005306)1.55254609
175Large earlobe (HP:0009748)1.55075501
176Hypopigmentation of the fundus (HP:0007894)1.53718263
177Vertebral arch anomaly (HP:0008438)1.53621592
178Heterochromia iridis (HP:0001100)1.53450668
179Polymicrogyria (HP:0002126)1.52143727

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.44896543
2MAP3K94.10703892
3BUB13.06271673
4KSR12.93223027
5NTRK32.87113335
6SRPK12.86094588
7MINK12.82180546
8TTK2.57212621
9NTRK22.38891143
10PAK62.27917269
11TRIB32.25863978
12PRKD32.25617528
13MAP3K42.24841762
14KSR22.01963186
15CASK2.00794421
16SIK31.96737367
17CDC71.91117238
18SMG11.77954623
19WEE11.76756605
20TYRO31.72745843
21UHMK11.72107519
22EIF2AK11.67250621
23BRD41.66473378
24SIK21.62667618
25EEF2K1.60907158
26CAMKK11.60706001
27DMPK1.60199896
28NEK21.50593059
29DAPK21.48693956
30SIK11.46424177
31CDK71.43140917
32RET1.42594877
33SCYL21.39620299
34TAOK11.37684880
35NTRK11.36305431
36CDK51.33776747
37EPHA41.32593792
38MAP3K121.30647647
39CHEK21.30020555
40PDGFRA1.28925147
41LATS21.27581554
42MAP2K41.27172780
43MAP3K21.24965178
44PKN21.19373482
45DAPK11.15825661
46MAP3K101.15416358
47MAP2K71.14709813
48BMPR21.12856776
49PAK31.11823969
50TSSK61.10198069
51MAPK131.10023443
52ICK1.06587834
53PRKCH1.06108764
54CDK181.05847932
55MARK21.02956396
56DYRK31.01084238
57ATR1.00897707
58TNIK1.00289386
59WNK30.98464307
60RIPK10.97731016
61CDK140.97432751
62EPHA20.95634968
63CDK150.95583219
64NEK10.94941513
65CLK10.94705981
66RPS6KA40.94459550
67CAMK1G0.94100764
68ALK0.93243692
69FGFR20.93061299
70ERBB30.92472084
71HIPK20.92034495
72PASK0.91898961
73PLK40.91586058
74EPHA30.91537306
75CHEK10.87608800
76TRIM280.83510853
77CDK11A0.82649650
78PHKG10.81616043
79PHKG20.81616043
80AURKB0.81539070
81PLK10.77895987
82EPHB10.74648549
83STK380.73047912
84AURKA0.72969611
85CDK10.72500360
86YES10.72022479
87CSNK1A1L0.70921660
88VRK20.70872710
89PTK60.70661590
90DYRK1A0.70040825
91PLK30.69444672
92CSNK1G20.68995736
93MAP3K60.68356546
94FES0.67924719
95CDK20.67116144
96BCR0.66780945
97DYRK20.66491032
98PLK20.66480021
99LRRK20.66201760
100MAP3K80.65939258
101CDK90.65924359
102MKNK10.65207158
103CDK190.64078150
104EPHB20.63096929
105RPS6KA20.63055454
106CAMKK20.62953197
107CSNK1G30.60440380
108CDK40.60369312
109ATM0.59676115
110CAMK1D0.58624756
111MAPK90.58122087
112CDK60.57789871
113STK110.57304852
114PDGFRB0.57218538
115PRKCG0.56754047
116MAPK100.55892462
117FGFR30.55494467
118RAF10.55262915
119PNCK0.55068512
120CDK80.54543382
121MAP3K10.53938507
122BRSK20.53770701
123BRAF0.52442054
124CDC42BPA0.51666136
125TAF10.50022839
126CSNK1E0.49702933
127PTK20.49327830
128FYN0.49162066
129DYRK1B0.49146338
130FER0.48249052
131FGFR10.47863999
132MAP3K50.47786738
133CDK120.47732646
134MTOR0.47697569
135PRKCZ0.46174078
136CDK30.45821231
137RPS6KB20.45674773
138PRKD20.45647632
139TESK10.45386123
140SGK30.45036771
141BRSK10.43246824
142MAP3K70.42623295
143EIF2AK20.42203404
144ITK0.41644776
145PRPF4B0.40936131
146LMTK20.40867516
147RPS6KA30.40275439
148GSK3B0.38788250
149MAPK150.37988405
150PDK10.37736725
151NEK60.37718818
152ERBB20.37704759
153FGFR40.35284482
154CCNB10.34563069

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.53122394
2Synaptic vesicle cycle_Homo sapiens_hsa047212.46454932
3DNA replication_Homo sapiens_hsa030302.44552552
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40079299
5Steroid biosynthesis_Homo sapiens_hsa001002.30847521
6Base excision repair_Homo sapiens_hsa034102.27678889
7Nicotine addiction_Homo sapiens_hsa050332.24261763
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12220015
9mRNA surveillance pathway_Homo sapiens_hsa030152.09642271
10GABAergic synapse_Homo sapiens_hsa047272.06258853
11Circadian entrainment_Homo sapiens_hsa047132.04393944
12Spliceosome_Homo sapiens_hsa030402.00317198
13Insulin secretion_Homo sapiens_hsa049111.99773851
14Long-term potentiation_Homo sapiens_hsa047201.95950211
15Dopaminergic synapse_Homo sapiens_hsa047281.92743416
16Olfactory transduction_Homo sapiens_hsa047401.92369057
17Mismatch repair_Homo sapiens_hsa034301.87591264
18Thyroid cancer_Homo sapiens_hsa052161.85539014
19Non-homologous end-joining_Homo sapiens_hsa034501.85485259
20Morphine addiction_Homo sapiens_hsa050321.80662091
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.80387635
22Glutamatergic synapse_Homo sapiens_hsa047241.74038156
23RNA transport_Homo sapiens_hsa030131.73744958
24Amphetamine addiction_Homo sapiens_hsa050311.72027263
25Cholinergic synapse_Homo sapiens_hsa047251.71166792
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70413971
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.65692709
28Cocaine addiction_Homo sapiens_hsa050301.64134383
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58923698
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56827070
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55937882
32Type II diabetes mellitus_Homo sapiens_hsa049301.53616809
33Biosynthesis of amino acids_Homo sapiens_hsa012301.49544510
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.48576168
35Lysine degradation_Homo sapiens_hsa003101.46711252
36Oxytocin signaling pathway_Homo sapiens_hsa049211.40743111
37Nucleotide excision repair_Homo sapiens_hsa034201.40565241
38Fanconi anemia pathway_Homo sapiens_hsa034601.37888598
39Glioma_Homo sapiens_hsa052141.36391614
40Estrogen signaling pathway_Homo sapiens_hsa049151.35706186
41Adherens junction_Homo sapiens_hsa045201.34039917
42Gap junction_Homo sapiens_hsa045401.33554569
43Salivary secretion_Homo sapiens_hsa049701.33340438
44Gastric acid secretion_Homo sapiens_hsa049711.32243731
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30931234
46Basal cell carcinoma_Homo sapiens_hsa052171.30666614
47Renin secretion_Homo sapiens_hsa049241.29592863
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.29342078
49Axon guidance_Homo sapiens_hsa043601.29139823
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26369348
51MicroRNAs in cancer_Homo sapiens_hsa052061.25167182
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24601215
53mTOR signaling pathway_Homo sapiens_hsa041501.24591767
54GnRH signaling pathway_Homo sapiens_hsa049121.24070876
55Carbohydrate digestion and absorption_Homo sapiens_hsa049731.23769805
56Endometrial cancer_Homo sapiens_hsa052131.22857727
57Long-term depression_Homo sapiens_hsa047301.22125285
58Oocyte meiosis_Homo sapiens_hsa041141.19870436
59ErbB signaling pathway_Homo sapiens_hsa040121.19775446
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17894793
61Colorectal cancer_Homo sapiens_hsa052101.17159796
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16264089
63Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13120694
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10701853
65VEGF signaling pathway_Homo sapiens_hsa043701.09867886
66Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07582013
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05769182
68Serotonergic synapse_Homo sapiens_hsa047261.04999748
69Prostate cancer_Homo sapiens_hsa052151.04867961
70Renal cell carcinoma_Homo sapiens_hsa052111.04257328
71Taste transduction_Homo sapiens_hsa047421.04141762
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00764182
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00362258
74cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00351139
75N-Glycan biosynthesis_Homo sapiens_hsa005100.99278486
76cAMP signaling pathway_Homo sapiens_hsa040240.98277181
77Non-small cell lung cancer_Homo sapiens_hsa052230.97322987
78Melanogenesis_Homo sapiens_hsa049160.96894306
79Basal transcription factors_Homo sapiens_hsa030220.94868022
80Chronic myeloid leukemia_Homo sapiens_hsa052200.92229678
81Carbon metabolism_Homo sapiens_hsa012000.91388642
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90701300
83Dorso-ventral axis formation_Homo sapiens_hsa043200.90029772
84Pancreatic cancer_Homo sapiens_hsa052120.87287431
85Vibrio cholerae infection_Homo sapiens_hsa051100.87017935
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86882005
87Calcium signaling pathway_Homo sapiens_hsa040200.85773335
88Acute myeloid leukemia_Homo sapiens_hsa052210.85302521
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84459479
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.83893245
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83218573
92Bladder cancer_Homo sapiens_hsa052190.82708910
93Endocytosis_Homo sapiens_hsa041440.82232465
94Alcoholism_Homo sapiens_hsa050340.81630694
95MAPK signaling pathway_Homo sapiens_hsa040100.81312817
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80803056
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.80452850
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79425108
99Pentose phosphate pathway_Homo sapiens_hsa000300.78724310
100T cell receptor signaling pathway_Homo sapiens_hsa046600.78387321
101Prolactin signaling pathway_Homo sapiens_hsa049170.77311448
102Fructose and mannose metabolism_Homo sapiens_hsa000510.75627568
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74605572
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.74227505
105Choline metabolism in cancer_Homo sapiens_hsa052310.73872232
106Glucagon signaling pathway_Homo sapiens_hsa049220.73153970
107Insulin signaling pathway_Homo sapiens_hsa049100.72854356
108Wnt signaling pathway_Homo sapiens_hsa043100.72614333
109Circadian rhythm_Homo sapiens_hsa047100.71872897
110Thyroid hormone synthesis_Homo sapiens_hsa049180.69191948
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.67832462
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66726734
113Inositol phosphate metabolism_Homo sapiens_hsa005620.66723373
114Dilated cardiomyopathy_Homo sapiens_hsa054140.66670967
115Hippo signaling pathway_Homo sapiens_hsa043900.66661979
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.64962679
117Notch signaling pathway_Homo sapiens_hsa043300.63793054
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.61608511
119Chemokine signaling pathway_Homo sapiens_hsa040620.60129641
120Rap1 signaling pathway_Homo sapiens_hsa040150.59529537
121Type I diabetes mellitus_Homo sapiens_hsa049400.59320376
122AMPK signaling pathway_Homo sapiens_hsa041520.58881671
123Pancreatic secretion_Homo sapiens_hsa049720.58737352
124Pyrimidine metabolism_Homo sapiens_hsa002400.58304383
125One carbon pool by folate_Homo sapiens_hsa006700.57893919
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57718860
127Hepatitis B_Homo sapiens_hsa051610.56774678
128Fatty acid metabolism_Homo sapiens_hsa012120.56196004
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55920413
130Viral carcinogenesis_Homo sapiens_hsa052030.55829505
131B cell receptor signaling pathway_Homo sapiens_hsa046620.55529938
132Proteoglycans in cancer_Homo sapiens_hsa052050.54748689
133Small cell lung cancer_Homo sapiens_hsa052220.54674708
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54645918
135Platelet activation_Homo sapiens_hsa046110.54011771
136Hedgehog signaling pathway_Homo sapiens_hsa043400.53700729
137p53 signaling pathway_Homo sapiens_hsa041150.53316309
138Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53205015
139Homologous recombination_Homo sapiens_hsa034400.53159250
140Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51997852
141Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51822623
142Ras signaling pathway_Homo sapiens_hsa040140.48821081
143Pathways in cancer_Homo sapiens_hsa052000.48723728
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48413600
145Selenocompound metabolism_Homo sapiens_hsa004500.47864128
146RNA polymerase_Homo sapiens_hsa030200.45974841
147Melanoma_Homo sapiens_hsa052180.45153579
148Tight junction_Homo sapiens_hsa045300.44392533
149Epstein-Barr virus infection_Homo sapiens_hsa051690.43825435
150Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41244525
151Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41200317
152RNA degradation_Homo sapiens_hsa030180.40828132
153TGF-beta signaling pathway_Homo sapiens_hsa043500.40768098
154Cysteine and methionine metabolism_Homo sapiens_hsa002700.39435393

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