DCAF13P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukotriene biosynthetic process (GO:0019370)7.17760021
2DNA deamination (GO:0045006)6.41982021
3regulation of ER to Golgi vesicle-mediated transport (GO:0060628)6.22455504
4regulation of chronic inflammatory response (GO:0002676)5.79523501
5response to pheromone (GO:0019236)5.50810755
6nonribosomal peptide biosynthetic process (GO:0019184)5.46904914
7cytidine deamination (GO:0009972)5.25369644
8cytidine metabolic process (GO:0046087)5.25369644
9cytidine catabolic process (GO:0006216)5.25369644
10glutathione biosynthetic process (GO:0006750)5.23186743
11ribosome assembly (GO:0042255)5.21852342
12regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.05577726
13proteasome assembly (GO:0043248)4.90090158
14negative regulation by host of viral transcription (GO:0043922)4.54508278
15regulation of isotype switching to IgG isotypes (GO:0048302)4.53016518
16pyrimidine ribonucleoside catabolic process (GO:0046133)4.52656789
17transcription from mitochondrial promoter (GO:0006390)4.50455153
18regulation of podosome assembly (GO:0071801)4.47338494
19negative regulation of T-helper cell differentiation (GO:0045623)4.31466797
20negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.31466797
21interferon-gamma secretion (GO:0072643)4.23316821
22proline transport (GO:0015824)4.20086730
23leukotriene metabolic process (GO:0006691)4.17733466
24protein K6-linked ubiquitination (GO:0085020)4.14899639
25alanine transport (GO:0032328)4.12569863
26maturation of 5.8S rRNA (GO:0000460)4.08521896
27positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.02248865
28regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.02248865
29icosanoid biosynthetic process (GO:0046456)3.99582389
30fatty acid derivative biosynthetic process (GO:1901570)3.99582389
31methionine biosynthetic process (GO:0009086)3.91253648
32regulation of immunoglobulin secretion (GO:0051023)3.88718583
33negative regulation of viral transcription (GO:0032897)3.83488359
34protein neddylation (GO:0045116)3.77528691
35peptide biosynthetic process (GO:0043043)3.73946965
36positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.72001657
37peptidyl-arginine omega-N-methylation (GO:0035247)3.63845132
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.59358985
39regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.57184627
40chaperone-mediated protein transport (GO:0072321)3.54981089
41regulation of MHC class II biosynthetic process (GO:0045346)3.52528476
42negative regulation of alpha-beta T cell differentiation (GO:0046639)3.42011137
43mitochondrial RNA metabolic process (GO:0000959)3.40147778
44positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.38026488
45negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.33116418
46glutathione metabolic process (GO:0006749)3.32613710
47sulfur amino acid biosynthetic process (GO:0000097)3.27254852
48histone arginine methylation (GO:0034969)3.24313493
49unsaturated fatty acid biosynthetic process (GO:0006636)3.22921114
50water-soluble vitamin biosynthetic process (GO:0042364)3.19599193
51methionine metabolic process (GO:0006555)3.18857922
52glycine transport (GO:0015816)3.12608883
53regulation of cellular amino acid metabolic process (GO:0006521)3.07989770
54T cell differentiation involved in immune response (GO:0002292)3.07730358
55alpha-beta T cell differentiation involved in immune response (GO:0002293)3.07730358
56alpha-beta T cell activation involved in immune response (GO:0002287)3.07730358
57phosphatidylethanolamine metabolic process (GO:0046337)3.06913171
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05691321
59CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.04888292
60L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.00083869
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99176677
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97363242
63positive regulation of chemokine biosynthetic process (GO:0045080)2.96239138
64peptidyl-arginine N-methylation (GO:0035246)2.92822353
65peptidyl-arginine methylation (GO:0018216)2.92822353
66regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.91125680
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.90860592
68negative regulation of ligase activity (GO:0051352)2.90860592
69DNA replication checkpoint (GO:0000076)2.90435208
70aspartate family amino acid biosynthetic process (GO:0009067)2.87439965
71positive regulation of isotype switching (GO:0045830)2.87103369
72positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.84674589
73positive regulation of granulocyte differentiation (GO:0030854)2.78876548
74regulation of nuclear cell cycle DNA replication (GO:0033262)2.78474630
75mitochondrial respiratory chain complex assembly (GO:0033108)2.77497710
76regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.75200007
77glutathione derivative biosynthetic process (GO:1901687)2.74269784
78glutathione derivative metabolic process (GO:1901685)2.74269784
79dopamine transport (GO:0015872)2.73977119
80piRNA metabolic process (GO:0034587)2.71823844
81intracellular protein transmembrane import (GO:0044743)2.68987462
82defense response to protozoan (GO:0042832)2.67877147
83estrogen biosynthetic process (GO:0006703)2.67390110
84DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.66257854
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.63643121
86signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.63643121
87signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.63643121
88positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.62636142
89neurotransmitter uptake (GO:0001504)2.61565977
90kinetochore assembly (GO:0051382)2.61440348
91negative regulation of interleukin-2 production (GO:0032703)2.60548308
92positive regulation of DNA recombination (GO:0045911)2.60500600
93mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.58940507
94artery development (GO:0060840)2.58933840
95signal transduction involved in cell cycle checkpoint (GO:0072395)2.57721920
96negative regulation of neurological system process (GO:0031645)2.57692731
97anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.57414032
98cullin deneddylation (GO:0010388)2.56966171
99signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.56904114
100intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.56904114

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human5.16407670
2EST1_17652178_ChIP-ChIP_JURKAT_Human3.42577015
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.41257768
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.36541896
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.29526870
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.10975690
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.90304097
8VDR_22108803_ChIP-Seq_LS180_Human2.87555018
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.78757650
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.78586352
11ZNF274_21170338_ChIP-Seq_K562_Hela2.63438404
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.59117757
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.52768379
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.50874032
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.32639027
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.29753085
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.26189949
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24579257
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13571749
20VDR_23849224_ChIP-Seq_CD4+_Human2.03726015
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.01741291
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93061008
23ELK1_19687146_ChIP-ChIP_HELA_Human1.91791030
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84146767
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.81002938
26PADI4_21655091_ChIP-ChIP_MCF-7_Human1.79093984
27EWS_26573619_Chip-Seq_HEK293_Human1.75325242
28ER_23166858_ChIP-Seq_MCF-7_Human1.71204181
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.69900731
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67425648
31FUS_26573619_Chip-Seq_HEK293_Human1.66302994
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66131130
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66048160
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63750580
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.62041906
36IGF1R_20145208_ChIP-Seq_DFB_Human1.61025390
37GBX2_23144817_ChIP-Seq_PC3_Human1.52556788
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50388840
39TAF15_26573619_Chip-Seq_HEK293_Human1.47496939
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45550744
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.45367375
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44627578
43FOXP3_21729870_ChIP-Seq_TREG_Human1.43523573
44P300_19829295_ChIP-Seq_ESCs_Human1.42679396
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41423823
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.40825881
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40633176
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.39630660
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39544992
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38905586
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38323389
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34946358
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.30542354
54BCAT_22108803_ChIP-Seq_LS180_Human1.30100941
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29891761
56MYC_18940864_ChIP-ChIP_HL60_Human1.29729040
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29057680
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28354195
59AR_21572438_ChIP-Seq_LNCaP_Human1.26770395
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.25513768
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22824320
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.20854969
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19519276
64IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18623988
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17529589
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17529589
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16955105
68CBP_20019798_ChIP-Seq_JUKART_Human1.16955105
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16342816
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10463443
71TP53_22573176_ChIP-Seq_HFKS_Human1.06727015
72TCF4_23295773_ChIP-Seq_U87_Human1.05889167
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05369152
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04839095
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.04722405
76NANOG_19829295_ChIP-Seq_ESCs_Human1.03708788
77SOX2_19829295_ChIP-Seq_ESCs_Human1.03708788
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03638417
79TCF4_22108803_ChIP-Seq_LS180_Human1.00772704
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00561997
81FLI1_21867929_ChIP-Seq_TH2_Mouse0.98722130
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98637195
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97872866
84SALL4_22934838_ChIP-ChIP_CD34+_Human0.95880842
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95164431
86MYC_18555785_ChIP-Seq_MESCs_Mouse0.94888234
87NCOR_22424771_ChIP-Seq_293T_Human0.93830470
88CRX_20693478_ChIP-Seq_RETINA_Mouse0.93611843
89HOXB7_26014856_ChIP-Seq_BT474_Human0.92395698
90MYB_26560356_Chip-Seq_TH2_Human0.91810250
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91752036
92OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90579902
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90104554
94GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.90049881
95SMAD4_21799915_ChIP-Seq_A2780_Human0.88737081
96TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88061166
97ELF5_23300383_ChIP-Seq_T47D_Human0.87828005
98THAP11_20581084_ChIP-Seq_MESCs_Mouse0.87683917
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.87220197
100ERG_20517297_ChIP-Seq_VCAP_Human0.86537146

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis5.27152286
2MP0003011_delayed_dark_adaptation3.97043010
3MP0001873_stomach_inflammation3.85399105
4MP0008995_early_reproductive_senescence3.61170912
5MP0005671_abnormal_response_to3.11590027
6MP0006082_CNS_inflammation2.54200908
7MP0001348_abnormal_lacrimal_gland2.46122445
8MP0003786_premature_aging2.43292929
9MP0001835_abnormal_antigen_presentation2.36860708
10MP0003880_abnormal_central_pattern2.35745655
11MP0005645_abnormal_hypothalamus_physiol2.30946943
12MP0003806_abnormal_nucleotide_metabolis2.25229280
13MP0002736_abnormal_nociception_after2.17782814
14MP0002876_abnormal_thyroid_physiology2.16529732
15MP0008872_abnormal_physiological_respon2.16019155
16MP0004147_increased_porphyrin_level2.01435368
17MP0009785_altered_susceptibility_to1.95293470
18MP0010094_abnormal_chromosome_stability1.91366860
19MP0002163_abnormal_gland_morphology1.79377092
20MP0000569_abnormal_digit_pigmentation1.76117802
21MP0002148_abnormal_hypersensitivity_rea1.74345671
22MP0008875_abnormal_xenobiotic_pharmacok1.73064973
23MP0002102_abnormal_ear_morphology1.70906448
24MP0006035_abnormal_mitochondrial_morpho1.70482641
25MP0001529_abnormal_vocalization1.58891347
26MP0002234_abnormal_pharynx_morphology1.58229381
27MP0006036_abnormal_mitochondrial_physio1.57008016
28MP0001968_abnormal_touch/_nociception1.54630362
29MP0003646_muscle_fatigue1.54173061
30MP0005310_abnormal_salivary_gland1.50580206
31MP0005646_abnormal_pituitary_gland1.48839765
32MP0008877_abnormal_DNA_methylation1.35529667
33MP0003693_abnormal_embryo_hatching1.31320974
34MP0006276_abnormal_autonomic_nervous1.28903837
35MP0005387_immune_system_phenotype1.28000724
36MP0001790_abnormal_immune_system1.28000724
37MP0001905_abnormal_dopamine_level1.27494660
38MP0003567_abnormal_fetal_cardiomyocyte1.25176331
39MP0004142_abnormal_muscle_tone1.24491096
40MP0002751_abnormal_autonomic_nervous1.24431651
41MP0002277_abnormal_respiratory_mucosa1.23832298
42MP0009333_abnormal_splenocyte_physiolog1.22900562
43MP0010307_abnormal_tumor_latency1.22794118
44MP0000613_abnormal_salivary_gland1.18989544
45MP0003045_fibrosis1.16997798
46MP0001293_anophthalmia1.16751654
47MP0000372_irregular_coat_pigmentation1.15283770
48MP0005332_abnormal_amino_acid1.15246805
49MP0005551_abnormal_eye_electrophysiolog1.14693740
50MP0008789_abnormal_olfactory_epithelium1.14299680
51MP0009697_abnormal_copulation1.12495542
52MP0001501_abnormal_sleep_pattern1.09627433
53MP0004742_abnormal_vestibular_system1.07098069
54MP0005000_abnormal_immune_tolerance1.06552112
55MP0003763_abnormal_thymus_physiology1.05130923
56MP0000631_abnormal_neuroendocrine_gland1.03408633
57MP0006072_abnormal_retinal_apoptosis1.03150629
58MP0003718_maternal_effect1.02562215
59MP0001800_abnormal_humoral_immune1.02081632
60MP0000685_abnormal_immune_system0.99241072
61MP0005647_abnormal_sex_gland0.97875953
62MP0002653_abnormal_ependyma_morphology0.97641874
63MP0005253_abnormal_eye_physiology0.96915303
64MP0001984_abnormal_olfaction0.96024188
65MP0008058_abnormal_DNA_repair0.94021251
66MP0001119_abnormal_female_reproductive0.90789795
67MP0004133_heterotaxia0.86023520
68MP0005379_endocrine/exocrine_gland_phen0.82663903
69MP0001958_emphysema0.81686090
70MP0001919_abnormal_reproductive_system0.79478741
71MP0000427_abnormal_hair_cycle0.79019211
72MP0003943_abnormal_hepatobiliary_system0.75981173
73MP0003878_abnormal_ear_physiology0.75502704
74MP0005377_hearing/vestibular/ear_phenot0.75502704
75MP0003137_abnormal_impulse_conducting0.75338201
76MP0002229_neurodegeneration0.75247331
77MP0002272_abnormal_nervous_system0.74684834
78MP0002210_abnormal_sex_determination0.74376267
79MP0004270_analgesia0.72046507
80MP0003936_abnormal_reproductive_system0.71315561
81MP0003937_abnormal_limbs/digits/tail_de0.70810832
82MP0003186_abnormal_redox_activity0.68935715
83MP0002089_abnormal_postnatal_growth/wei0.68693577
84MP0001502_abnormal_circadian_rhythm0.68462424
85MP0004957_abnormal_blastocyst_morpholog0.68337317
86MP0002405_respiratory_system_inflammati0.67809083
87MP0004084_abnormal_cardiac_muscle0.67217256
88MP0005395_other_phenotype0.66590535
89MP0001881_abnormal_mammary_gland0.66524206
90MP0002723_abnormal_immune_serum0.65848032
91MP0005075_abnormal_melanosome_morpholog0.65845688
92MP0003436_decreased_susceptibility_to0.64576600
93MP0002420_abnormal_adaptive_immunity0.63757149
94MP0004145_abnormal_muscle_electrophysio0.63082842
95MP0005584_abnormal_enzyme/coenzyme_acti0.62431983
96MP0002693_abnormal_pancreas_physiology0.60901152
97MP0003959_abnormal_lean_body0.60661351
98MP0000689_abnormal_spleen_morphology0.60409388
99MP0001819_abnormal_immune_cell0.60318788
100MP0002006_tumorigenesis0.60087010

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.58630603
2Abnormality of homocysteine metabolism (HP:0010919)4.16229972
3Homocystinuria (HP:0002156)4.16229972
4Acute encephalopathy (HP:0006846)3.80594542
5Stomatitis (HP:0010280)3.74581886
6Progressive macrocephaly (HP:0004481)3.70350073
7Abnormal mitochondria in muscle tissue (HP:0008316)3.69298440
8Abnormality of methionine metabolism (HP:0010901)3.44795693
9Gonadotropin excess (HP:0000837)3.35027087
10Central scotoma (HP:0000603)3.30067393
11Pendular nystagmus (HP:0012043)3.29906562
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.23045047
13Mitochondrial inheritance (HP:0001427)3.17327874
14True hermaphroditism (HP:0010459)3.11116747
15Panhypogammaglobulinemia (HP:0003139)3.06304358
16Abnormality of macular pigmentation (HP:0008002)3.05087989
17Abnormality of the vitamin B12 metabolism (HP:0004341)2.96118693
18Type 2 muscle fiber atrophy (HP:0003554)2.93025561
19Abnormality of midbrain morphology (HP:0002418)2.91248170
20Molar tooth sign on MRI (HP:0002419)2.91248170
21Cerebral edema (HP:0002181)2.85656720
22Abnormality of aspartate family amino acid metabolism (HP:0010899)2.85198110
23Increased CSF lactate (HP:0002490)2.83852032
24Abnormality of vitamin B metabolism (HP:0004340)2.78515394
25Carpal bone hypoplasia (HP:0001498)2.75219989
26Absent/shortened dynein arms (HP:0200106)2.69907286
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.69907286
28Pancreatic cysts (HP:0001737)2.63744055
29Abnormality of the labia minora (HP:0012880)2.61089681
30Arthropathy (HP:0003040)2.55801694
31Supernumerary spleens (HP:0009799)2.54621176
32Meckel diverticulum (HP:0002245)2.54489133
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.54118376
34Optic disc pallor (HP:0000543)2.52346187
35Chronic mucocutaneous candidiasis (HP:0002728)2.49785473
36Recurrent cutaneous fungal infections (HP:0011370)2.49785473
37IgG deficiency (HP:0004315)2.48517511
38Pancreatic fibrosis (HP:0100732)2.46790886
39Abnormality of the ileum (HP:0001549)2.45205440
40Nephronophthisis (HP:0000090)2.43978690
41Muscle fiber atrophy (HP:0100295)2.42347928
42Abnormality of sulfur amino acid metabolism (HP:0004339)2.38914618
43Attenuation of retinal blood vessels (HP:0007843)2.35914528
44Pheochromocytoma (HP:0002666)2.35595142
45Episodic fever (HP:0001954)2.34940419
46Scotoma (HP:0000575)2.34450537
47Renal Fanconi syndrome (HP:0001994)2.33271026
48Palpebral edema (HP:0100540)2.29983115
49Increased hepatocellular lipid droplets (HP:0006565)2.27544219
50Abnormality of the fovea (HP:0000493)2.26459638
51Megaloblastic anemia (HP:0001889)2.24261712
52Decreased central vision (HP:0007663)2.21691593
53Abnormal number of incisors (HP:0011064)2.19789585
54Glioma (HP:0009733)2.18809873
55Neuroendocrine neoplasm (HP:0100634)2.17946976
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15410665
57Hypoplasia of the pons (HP:0012110)2.12974995
58Midline defect of the nose (HP:0004122)2.12856655
59Anencephaly (HP:0002323)2.11508203
60Nausea (HP:0002018)2.10188696
61Submucous cleft hard palate (HP:0000176)2.08783970
62Lipid accumulation in hepatocytes (HP:0006561)2.07265723
63Hypoproteinemia (HP:0003075)2.06928893
64Keratoconus (HP:0000563)2.05883198
65Increased corneal curvature (HP:0100692)2.05883198
66Abnormality of serum amino acid levels (HP:0003112)1.98295843
67Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.98282358
68Diastasis recti (HP:0001540)1.96876292
69Brushfield spots (HP:0001088)1.96756345
70Abnormality of T cell number (HP:0011839)1.96581246
71Abnormal rod and cone electroretinograms (HP:0008323)1.95099883
72Abolished electroretinogram (ERG) (HP:0000550)1.94690713
73Autoimmune hemolytic anemia (HP:0001890)1.94558808
74Abnormal respiratory epithelium morphology (HP:0012253)1.93474898
75Abnormal respiratory motile cilium morphology (HP:0005938)1.93474898
76Severe global developmental delay (HP:0011344)1.93293603
77Abnormality of the pons (HP:0007361)1.92092699
78T lymphocytopenia (HP:0005403)1.91399477
79Methylmalonic acidemia (HP:0002912)1.90161350
80Leukodystrophy (HP:0002415)1.89819890
81Chronic hepatic failure (HP:0100626)1.88423353
82Type I transferrin isoform profile (HP:0003642)1.88383010
83Pustule (HP:0200039)1.87231936
84Exertional dyspnea (HP:0002875)1.85381110
85Paralysis (HP:0003470)1.85004053
86Severe visual impairment (HP:0001141)1.83906566
87Gonadal dysgenesis (HP:0000133)1.83839814
88Hypomagnesemia (HP:0002917)1.83811317
89Abnormality of T cell physiology (HP:0011840)1.83457932
90Abnormality of T cells (HP:0002843)1.83173134
91Hepatocellular necrosis (HP:0001404)1.82606272
92Broad alveolar ridges (HP:0000187)1.81960488
93Abnormality of the renal medulla (HP:0100957)1.81848791
94Male pseudohermaphroditism (HP:0000037)1.81665335
95Abnormal ciliary motility (HP:0012262)1.79873367
96Inability to walk (HP:0002540)1.79820773
97Lethargy (HP:0001254)1.79500841
98Meningioma (HP:0002858)1.78647078
99Thyroiditis (HP:0100646)1.77314202
100Abnormality of the astrocytes (HP:0100707)1.76756052

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK65.06551758
2PBK4.70756727
3MAP4K24.67210870
4BUB13.41870721
5EPHA33.05959080
6MST43.04071088
7PINK12.86557078
8EIF2AK12.77219769
9TXK2.49567747
10SRPK12.31603227
11ZAK2.27481202
12EIF2AK32.14832834
13NME11.97220791
14VRK21.90538538
15TLK11.89444158
16WNK31.87709393
17STK391.86616758
18ADRBK21.80209475
19WNK41.79178916
20BMPR1B1.71785579
21OXSR11.70062098
22NEK11.63349213
23NTRK31.52074573
24PLK31.37674165
25TEC1.23315364
26FRK1.22697471
27TNIK1.22613726
28CASK1.22443998
29MATK1.18729848
30BRD41.17203401
31MAPK131.12443887
32TTK1.00156208
33MAP2K60.97735811
34ALK0.97132049
35PIK3CG0.93699214
36EIF2AK20.92239336
37MKNK10.88535408
38NTRK10.86034333
39VRK10.82488472
40CAMKK20.78662587
41TAF10.78355003
42BRSK20.75885480
43JAK30.75647654
44TAOK30.75392133
45GRK10.72470749
46BCKDK0.71444273
47NUAK10.70552416
48NLK0.69682550
49PRKG20.69257844
50CDK30.68131790
51EPHA40.63408853
52ATR0.61515732
53KDR0.61021184
54IKBKB0.60889984
55ACVR1B0.58159883
56CDC70.56392115
57LCK0.56288389
58ADRBK10.52704758
59BCR0.51994519
60MINK10.51325709
61MAP3K120.50791914
62WEE10.50503730
63DYRK20.50398516
64PLK10.48098700
65IGF1R0.47242483
66MAP3K40.45808135
67MAP3K50.45095991
68FGFR10.45002100
69MAPKAPK50.44987225
70MKNK20.44374472
71GRK70.43917687
72ITK0.43596445
73EPHB20.42168841
74WNK10.42068794
75TRIM280.40796460
76MAP4K10.39689981
77SYK0.39558718
78ATM0.39036054
79OBSCN0.38248270
80BMPR20.37753401
81TIE10.37050164
82PLK20.36278952
83PRKCQ0.35500818
84CDK80.34953500
85TYK20.34499523
86AURKB0.32033798
87CDK90.31921779
88INSRR0.30828189
89STK40.28051483
90YES10.27592068
91NEK20.26497388
92RPS6KB20.25624942
93CSNK1A10.25176413
94IRAK10.23603415
95PIK3CA0.22600130
96PHKG10.19403136
97PHKG20.19403136
98CAMK2A0.18864008
99CSNK2A20.18780872
100CSNK1E0.18544689

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.67561155
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.11303791
3Selenocompound metabolism_Homo sapiens_hsa004503.04670462
4One carbon pool by folate_Homo sapiens_hsa006702.99323349
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.96023045
6Allograft rejection_Homo sapiens_hsa053302.71813301
7Primary immunodeficiency_Homo sapiens_hsa053402.58281094
8Oxidative phosphorylation_Homo sapiens_hsa001902.46613485
9RNA polymerase_Homo sapiens_hsa030202.36768737
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23213148
11Asthma_Homo sapiens_hsa053102.16359948
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15223512
13Autoimmune thyroid disease_Homo sapiens_hsa053202.10901336
14Parkinsons disease_Homo sapiens_hsa050122.08620147
15Homologous recombination_Homo sapiens_hsa034401.93690395
16Fanconi anemia pathway_Homo sapiens_hsa034601.88734367
17Protein export_Homo sapiens_hsa030601.77287372
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.66843405
19Graft-versus-host disease_Homo sapiens_hsa053321.57266610
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55439041
21Caffeine metabolism_Homo sapiens_hsa002321.54121709
22Type I diabetes mellitus_Homo sapiens_hsa049401.53119412
23Huntingtons disease_Homo sapiens_hsa050161.45067623
24Basal transcription factors_Homo sapiens_hsa030221.42805573
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.40574462
26Mismatch repair_Homo sapiens_hsa034301.39807078
27RNA degradation_Homo sapiens_hsa030181.37047031
28Non-homologous end-joining_Homo sapiens_hsa034501.35929216
29Linoleic acid metabolism_Homo sapiens_hsa005911.32801481
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.30963944
31Nucleotide excision repair_Homo sapiens_hsa034201.29937459
32Antigen processing and presentation_Homo sapiens_hsa046121.25418418
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19151268
34Propanoate metabolism_Homo sapiens_hsa006401.15610628
35Alzheimers disease_Homo sapiens_hsa050101.14501438
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13276799
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09602993
38Hematopoietic cell lineage_Homo sapiens_hsa046401.08633491
39Nitrogen metabolism_Homo sapiens_hsa009101.07810796
40DNA replication_Homo sapiens_hsa030301.05352836
41Phototransduction_Homo sapiens_hsa047441.05153149
42Pyrimidine metabolism_Homo sapiens_hsa002401.04987299
43Rheumatoid arthritis_Homo sapiens_hsa053231.01727611
44Ribosome_Homo sapiens_hsa030100.99928046
45T cell receptor signaling pathway_Homo sapiens_hsa046600.98399895
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97346932
47Butanoate metabolism_Homo sapiens_hsa006500.96291627
48beta-Alanine metabolism_Homo sapiens_hsa004100.93085163
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.90700965
50Purine metabolism_Homo sapiens_hsa002300.86932048
51RNA transport_Homo sapiens_hsa030130.85235910
52Folate biosynthesis_Homo sapiens_hsa007900.83864424
53Measles_Homo sapiens_hsa051620.81244571
54Spliceosome_Homo sapiens_hsa030400.80977783
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79687892
56Nicotine addiction_Homo sapiens_hsa050330.78861786
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74349867
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72893690
59Peroxisome_Homo sapiens_hsa041460.71980678
60Retinol metabolism_Homo sapiens_hsa008300.71379852
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71333527
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.67842962
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67792320
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64008732
65Olfactory transduction_Homo sapiens_hsa047400.58957919
66Regulation of autophagy_Homo sapiens_hsa041400.57878532
67Base excision repair_Homo sapiens_hsa034100.57170589
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56462582
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55191754
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54727453
71Ether lipid metabolism_Homo sapiens_hsa005650.53600911
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53548875
73Arachidonic acid metabolism_Homo sapiens_hsa005900.51934517
74Glutathione metabolism_Homo sapiens_hsa004800.50596068
75Collecting duct acid secretion_Homo sapiens_hsa049660.50433225
76GABAergic synapse_Homo sapiens_hsa047270.49606557
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.49236306
78Morphine addiction_Homo sapiens_hsa050320.48580915
79Malaria_Homo sapiens_hsa051440.47525110
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45738538
81Metabolic pathways_Homo sapiens_hsa011000.42719735
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42219310
83African trypanosomiasis_Homo sapiens_hsa051430.41753504
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.39663526
85mRNA surveillance pathway_Homo sapiens_hsa030150.39150071
86Tryptophan metabolism_Homo sapiens_hsa003800.38383712
87Hedgehog signaling pathway_Homo sapiens_hsa043400.36056721
88Chemical carcinogenesis_Homo sapiens_hsa052040.34055279
89Pyruvate metabolism_Homo sapiens_hsa006200.31918812
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30783864
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28824162
92Epstein-Barr virus infection_Homo sapiens_hsa051690.28000041
93Cardiac muscle contraction_Homo sapiens_hsa042600.27100034
94Glycerolipid metabolism_Homo sapiens_hsa005610.25497097
95p53 signaling pathway_Homo sapiens_hsa041150.25496888
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25149854
97Cell cycle_Homo sapiens_hsa041100.24334691
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23559654
99Herpes simplex infection_Homo sapiens_hsa051680.22707719
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.21381902

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