DCAF13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)4.50661108
2proteasome assembly (GO:0043248)4.49403677
3formation of translation preinitiation complex (GO:0001731)4.46348905
4purine nucleobase biosynthetic process (GO:0009113)4.43718682
5ribosome assembly (GO:0042255)4.31908674
6nucleobase biosynthetic process (GO:0046112)4.28988755
7DNA double-strand break processing (GO:0000729)4.23744887
8DNA deamination (GO:0045006)4.22397313
9ribosome biogenesis (GO:0042254)4.20081720
10mitotic metaphase plate congression (GO:0007080)4.13295042
11maturation of SSU-rRNA (GO:0030490)4.06499101
12DNA strand elongation involved in DNA replication (GO:0006271)4.05446361
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.95547443
14DNA replication initiation (GO:0006270)3.95235848
15DNA replication checkpoint (GO:0000076)3.94921084
16telomere maintenance via semi-conservative replication (GO:0032201)3.88001707
17DNA strand elongation (GO:0022616)3.85721994
18positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.85391286
19regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.84479315
20ribosomal small subunit assembly (GO:0000028)3.82207460
21regulation of mitotic spindle checkpoint (GO:1903504)3.81254265
22regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.81254265
23anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.80045319
24ribonucleoprotein complex biogenesis (GO:0022613)3.78846759
25negative regulation of DNA-dependent DNA replication (GO:2000104)3.64304531
26establishment of protein localization to mitochondrial membrane (GO:0090151)3.64263149
27telomere maintenance via recombination (GO:0000722)3.61670068
28CENP-A containing nucleosome assembly (GO:0034080)3.59984101
29negative regulation of ligase activity (GO:0051352)3.54986175
30negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.54986175
31IMP metabolic process (GO:0046040)3.54676866
32chromatin remodeling at centromere (GO:0031055)3.53858718
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.52599664
34rRNA modification (GO:0000154)3.52523795
35protein neddylation (GO:0045116)3.52491312
36replication fork processing (GO:0031297)3.51446028
37regulation of centriole replication (GO:0046599)3.50538986
38establishment of viral latency (GO:0019043)3.50324673
39exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.49846120
40ribosomal large subunit biogenesis (GO:0042273)3.49669679
41DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.49570426
42chaperone-mediated protein transport (GO:0072321)3.48783579
43DNA catabolic process, exonucleolytic (GO:0000738)3.48535332
44DNA ligation (GO:0006266)3.47568088
45metaphase plate congression (GO:0051310)3.46592808
46intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.45138311
47signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.45138311
48signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.44958178
49signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.44958178
50signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.44958178
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.43590962
52termination of RNA polymerase III transcription (GO:0006386)3.42484827
53transcription elongation from RNA polymerase III promoter (GO:0006385)3.42484827
54antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.42153279
55positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.41421033
56* rRNA processing (GO:0006364)3.41288105
57mitotic nuclear envelope disassembly (GO:0007077)3.38955319
58somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.38435134
59somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.38435134
60isotype switching (GO:0045190)3.38435134
61signal transduction involved in DNA damage checkpoint (GO:0072422)3.38381071
62signal transduction involved in DNA integrity checkpoint (GO:0072401)3.38381071
63non-recombinational repair (GO:0000726)3.34965024
64double-strand break repair via nonhomologous end joining (GO:0006303)3.34965024
65mitotic spindle checkpoint (GO:0071174)3.34924066
66mitotic recombination (GO:0006312)3.34861533
67regulation of cellular amino acid metabolic process (GO:0006521)3.34716344
68signal transduction involved in cell cycle checkpoint (GO:0072395)3.33572699
69pseudouridine synthesis (GO:0001522)3.33376238
70negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.31401212
71protein localization to kinetochore (GO:0034501)3.29986709
72regulation of helicase activity (GO:0051095)3.29280627
73* rRNA metabolic process (GO:0016072)3.29267878
74antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.28826699
75DNA replication-independent nucleosome assembly (GO:0006336)3.27904821
76DNA replication-independent nucleosome organization (GO:0034724)3.27904821
77DNA damage response, detection of DNA damage (GO:0042769)3.26656855
78spliceosomal snRNP assembly (GO:0000387)3.26063033
79positive regulation of ligase activity (GO:0051351)3.25454970
80maturation of 5.8S rRNA (GO:0000460)3.25411558
81G1/S transition of mitotic cell cycle (GO:0000082)3.25281544
82cell cycle G1/S phase transition (GO:0044843)3.25281544
83somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25254727
84somatic hypermutation of immunoglobulin genes (GO:0016446)3.25254727
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23524603
867-methylguanosine mRNA capping (GO:0006370)3.22802983
87rRNA methylation (GO:0031167)3.21727851
88IMP biosynthetic process (GO:0006188)3.20563874
89telomere maintenance via telomere lengthening (GO:0010833)3.20022737
90RNA capping (GO:0036260)3.19797921
917-methylguanosine RNA capping (GO:0009452)3.19797921
92attachment of spindle microtubules to kinetochore (GO:0008608)3.17764560
93termination of RNA polymerase I transcription (GO:0006363)3.17352252
94kinetochore organization (GO:0051383)3.15471631
95establishment of chromosome localization (GO:0051303)3.15170499
96regulation of spindle organization (GO:0090224)3.14908703
97ribosomal small subunit biogenesis (GO:0042274)3.14827453
98maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.14172966
99DNA replication-dependent nucleosome organization (GO:0034723)3.13996269
100DNA replication-dependent nucleosome assembly (GO:0006335)3.13996269
101membrane disassembly (GO:0030397)3.10970698
102nuclear envelope disassembly (GO:0051081)3.10970698
103histone mRNA metabolic process (GO:0008334)3.10058316
104regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.09587136
105regulation of mitotic metaphase/anaphase transition (GO:0030071)3.09587136
106cullin deneddylation (GO:0010388)3.08393145
107amino acid activation (GO:0043038)3.08046628
108tRNA aminoacylation (GO:0043039)3.08046628
109kinetochore assembly (GO:0051382)3.07638390
110negative regulation of DNA recombination (GO:0045910)3.06451414
111mitochondrial RNA metabolic process (GO:0000959)3.06205928
112tRNA aminoacylation for protein translation (GO:0006418)3.06152662
113transcription from RNA polymerase I promoter (GO:0006360)3.03985350
114folic acid-containing compound biosynthetic process (GO:0009396)3.03509506
115transcription elongation from RNA polymerase I promoter (GO:0006362)3.02944588
116response to X-ray (GO:0010165)3.02641821
117respiratory chain complex IV assembly (GO:0008535)3.02504510
118nuclear pore organization (GO:0006999)3.01806893
119regulation of ubiquitin-protein transferase activity (GO:0051438)3.00899621
120protein deneddylation (GO:0000338)2.98572643
121transcription-coupled nucleotide-excision repair (GO:0006283)2.98051593
122translational initiation (GO:0006413)2.97563741
123DNA unwinding involved in DNA replication (GO:0006268)2.96305506
124folic acid metabolic process (GO:0046655)2.94556910
125histone exchange (GO:0043486)2.93714574
126cellular component biogenesis (GO:0044085)2.93713876
127positive regulation of cell cycle arrest (GO:0071158)2.91168145
128viral mRNA export from host cell nucleus (GO:0046784)2.91008508
129nucleotide-excision repair, DNA gap filling (GO:0006297)2.90215575
130spindle checkpoint (GO:0031577)2.89388083
131regulation of ligase activity (GO:0051340)2.89254917
132negative regulation of mitotic sister chromatid separation (GO:2000816)2.85738792
133negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85738792
134negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85738792
135negative regulation of sister chromatid segregation (GO:0033046)2.85738792
136DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.85719729
137mitotic spindle assembly checkpoint (GO:0007094)2.84179241
138translational termination (GO:0006415)2.83656468
139spindle assembly checkpoint (GO:0071173)2.83583289
140negative regulation of chromosome segregation (GO:0051985)2.83144068

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.18082824
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.18891273
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.73558895
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.60805321
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.49899539
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.34228228
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.31184641
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.21617749
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.06457196
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.00078934
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.87934063
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.79557959
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74904245
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73946482
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71173468
16* VDR_23849224_ChIP-Seq_CD4+_Human2.57054298
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37922558
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.34962773
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32139845
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.30368967
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25542059
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.20230040
23XRN2_22483619_ChIP-Seq_HELA_Human2.18638855
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.11582626
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11190667
26FOXP3_21729870_ChIP-Seq_TREG_Human2.10291693
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09886573
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09756282
29DCP1A_22483619_ChIP-Seq_HELA_Human2.07215749
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04358333
31ELK1_19687146_ChIP-ChIP_HELA_Human2.02608143
32GABP_19822575_ChIP-Seq_HepG2_Human1.96398965
33AR_21909140_ChIP-Seq_LNCAP_Human1.92816577
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91389902
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86133639
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.83267981
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79173525
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.76980193
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74697735
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73535180
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.72970382
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.72866459
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71384580
44TTF2_22483619_ChIP-Seq_HELA_Human1.71355777
45EWS_26573619_Chip-Seq_HEK293_Human1.70750893
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69749335
47ZNF274_21170338_ChIP-Seq_K562_Hela1.65897637
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65450230
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.64726799
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.63276401
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62137278
52VDR_22108803_ChIP-Seq_LS180_Human1.60665165
53* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55870132
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.55087567
55KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.53563182
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53222801
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52544302
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49628122
59FUS_26573619_Chip-Seq_HEK293_Human1.48649270
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48222570
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45037918
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44462552
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43110619
64* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40437159
65IRF8_21731497_ChIP-ChIP_J774_Mouse1.38840865
66KDM5A_27292631_Chip-Seq_BREAST_Human1.38406931
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37975775
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36519074
69IRF8_22096565_ChIP-ChIP_GC-B_Human1.35762098
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33615058
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33021413
72CIITA_25753668_ChIP-Seq_RAJI_Human1.33015194
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32603761
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.31943891
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29724791
76TFEB_21752829_ChIP-Seq_HELA_Human1.28298555
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23744315
78* SPI1_23547873_ChIP-Seq_NB4_Human1.23439277
79ELK1_22589737_ChIP-Seq_MCF10A_Human1.20256174
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15353748
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10994032
82SOX2_16153702_ChIP-ChIP_HESCs_Human1.09062284
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08215195
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07927146
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06266998
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06143011
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05839026
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03723551
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00949975
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98440059
91* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98319391
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98147553
93* MYC_22102868_ChIP-Seq_BL_Human0.98051475
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97571353
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95191689
96IGF1R_20145208_ChIP-Seq_DFB_Human0.94752453
97SOX17_20123909_ChIP-Seq_XEN_Mouse0.93642977
98MYC_18940864_ChIP-ChIP_HL60_Human0.92642245
99TAF15_26573619_Chip-Seq_HEK293_Human0.90789238
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.89198309
101MYB_21317192_ChIP-Seq_ERMYB_Mouse0.87891619
102IRF1_19129219_ChIP-ChIP_H3396_Human0.87572105
103P300_19829295_ChIP-Seq_ESCs_Human0.86506142
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86014040
105CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85689997
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85634885
107MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.85547032
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85408317
109STAT4_19710469_ChIP-ChIP_TH1__Mouse0.83295319
110RBPJ_22232070_ChIP-Seq_NCS_Mouse0.82087975
111CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82037484
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81864266
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81715919
114* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81523989
115TP63_19390658_ChIP-ChIP_HaCaT_Human0.81410715
116ELF5_23300383_ChIP-Seq_T47D_Human0.79076461
117CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.78537928
118CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.77479253
119SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.76728763
120NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.76194484
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75005771
122PCGF2_27294783_Chip-Seq_NPCs_Mouse0.74774303
123CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.73814457
124SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.73794379
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.72882159
126SUZ12_27294783_Chip-Seq_NPCs_Mouse0.72105853
127* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71013928
128SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.70659239
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.70216206
130EZH2_27294783_Chip-Seq_NPCs_Mouse0.70150447
131SOX2_18555785_ChIP-Seq_MESCs_Mouse0.69895957
132NFE2_27457419_Chip-Seq_LIVER_Mouse0.69762134
133ZFP57_27257070_Chip-Seq_ESCs_Mouse0.68369431

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.45628608
2MP0010094_abnormal_chromosome_stability4.21987596
3MP0004957_abnormal_blastocyst_morpholog4.11167879
4MP0003111_abnormal_nucleus_morphology3.92080127
5MP0003077_abnormal_cell_cycle3.75052475
6MP0008058_abnormal_DNA_repair3.63137466
7MP0008057_abnormal_DNA_replication3.35095131
8MP0008007_abnormal_cellular_replicative2.83103686
9MP0002396_abnormal_hematopoietic_system2.47207481
10MP0008932_abnormal_embryonic_tissue2.37589363
11MP0001835_abnormal_antigen_presentation2.28314268
12MP0003890_abnormal_embryonic-extraembry2.23088029
13MP0008877_abnormal_DNA_methylation2.15965817
14MP0003786_premature_aging2.14642377
15MP0003718_maternal_effect2.10237376
16MP0009333_abnormal_splenocyte_physiolog2.04571690
17MP0001293_anophthalmia2.00334336
18MP0006072_abnormal_retinal_apoptosis1.96552556
19MP0003123_paternal_imprinting1.94722155
20MP0000350_abnormal_cell_proliferation1.91248960
21MP0001730_embryonic_growth_arrest1.90500642
22MP0002938_white_spotting1.85007094
23MP0010352_gastrointestinal_tract_polyps1.79203589
24MP0001545_abnormal_hematopoietic_system1.76891170
25MP0005397_hematopoietic_system_phenotyp1.76891170
26MP0006035_abnormal_mitochondrial_morpho1.76268136
27MP0005671_abnormal_response_to1.75772592
28MP0010307_abnormal_tumor_latency1.73706579
29MP0008260_abnormal_autophagy1.71083718
30MP0002102_abnormal_ear_morphology1.67765999
31MP0003186_abnormal_redox_activity1.66566583
32MP0009785_altered_susceptibility_to1.64680835
33MP0003763_abnormal_thymus_physiology1.64044797
34MP0000372_irregular_coat_pigmentation1.62326469
35MP0000490_abnormal_crypts_of1.62274610
36MP0003806_abnormal_nucleotide_metabolis1.51549574
37MP0004808_abnormal_hematopoietic_stem1.50540464
38MP0002398_abnormal_bone_marrow1.50240310
39MP0003436_decreased_susceptibility_to1.48040637
40MP0001529_abnormal_vocalization1.47821622
41MP0003937_abnormal_limbs/digits/tail_de1.46611113
42MP0002019_abnormal_tumor_incidence1.45928507
43MP0000313_abnormal_cell_death1.42539423
44MP0000685_abnormal_immune_system1.40480517
45MP0000689_abnormal_spleen_morphology1.32742811
46MP0002452_abnormal_antigen_presenting1.31449805
47MP0002722_abnormal_immune_system1.30313591
48MP0005380_embryogenesis_phenotype1.29057324
49MP0001672_abnormal_embryogenesis/_devel1.29057324
50MP0002148_abnormal_hypersensitivity_rea1.28743202
51MP0001853_heart_inflammation1.27724507
52MP0001697_abnormal_embryo_size1.27119200
53MP0001800_abnormal_humoral_immune1.26483687
54MP0001819_abnormal_immune_cell1.25869061
55MP0002420_abnormal_adaptive_immunity1.25812967
56MP0005000_abnormal_immune_tolerance1.25572095
57MP0002429_abnormal_blood_cell1.24453029
58MP0002080_prenatal_lethality1.24040942
59MP0000716_abnormal_immune_system1.22546968
60MP0002723_abnormal_immune_serum1.19765998
61MP0000858_altered_metastatic_potential1.18672210
62MP0003984_embryonic_growth_retardation1.18027319
63MP0005025_abnormal_response_to1.17850990
64MP0009672_abnormal_birth_weight1.16538374
65MP0008789_abnormal_olfactory_epithelium1.16084205
66MP0003121_genomic_imprinting1.15235382
67MP0001188_hyperpigmentation1.13411905
68MP0002088_abnormal_embryonic_growth/wei1.13014236
69MP0004147_increased_porphyrin_level1.12140945
70MP0002751_abnormal_autonomic_nervous1.12099735
71MP0002210_abnormal_sex_determination1.12083402
72MP0002419_abnormal_innate_immunity1.09352463
73MP0003567_abnormal_fetal_cardiomyocyte1.08777712
74MP0002132_abnormal_respiratory_system1.08459791
75MP0003136_yellow_coat_color1.06483320
76MP0001286_abnormal_eye_development1.05410416
77MP0008995_early_reproductive_senescence1.05235359
78MP0006082_CNS_inflammation1.04793564
79MP0003119_abnormal_digestive_system1.04735249
80MP0000703_abnormal_thymus_morphology1.04438164
81MP0000647_abnormal_sebaceous_gland1.03905962
82MP0002086_abnormal_extraembryonic_tissu0.99050700
83MP0002405_respiratory_system_inflammati0.98629475
84MP0002006_tumorigenesis0.98362655
85MP0003221_abnormal_cardiomyocyte_apopto0.97224475
86MP0000358_abnormal_cell_content/0.96786854
87MP0005253_abnormal_eye_physiology0.95982628
88MP0003941_abnormal_skin_development0.95136176
89MP0005084_abnormal_gallbladder_morpholo0.94428125
90MP0002090_abnormal_vision0.94144422
91MP0001145_abnormal_male_reproductive0.94029122
92MP0002233_abnormal_nose_morphology0.92333944
93MP0009697_abnormal_copulation0.91929461
94MP0004133_heterotaxia0.91516174
95MP0010030_abnormal_orbit_morphology0.91299179
96MP0001119_abnormal_female_reproductive0.90833473
97MP0002111_abnormal_tail_morphology0.89395471
98MP0002254_reproductive_system_inflammat0.89110220
99MP0005408_hypopigmentation0.88641776
100MP0003724_increased_susceptibility_to0.88481624
101MP0000427_abnormal_hair_cycle0.88130214
102MP0001542_abnormal_bone_strength0.86950752
103MP0005389_reproductive_system_phenotype0.86030760
104MP0005621_abnormal_cell_physiology0.84917570
105MP0002160_abnormal_reproductive_system0.84565726
106MP0004782_abnormal_surfactant_physiolog0.84488513
107MP0005395_other_phenotype0.84376628
108MP0002166_altered_tumor_susceptibility0.82915093
109MP0002163_abnormal_gland_morphology0.82777607
110MP0002736_abnormal_nociception_after0.82690791
111MP0002697_abnormal_eye_size0.82332117
112MP0005384_cellular_phenotype0.81906139
113MP0002085_abnormal_embryonic_tissue0.81819910
114MP0000653_abnormal_sex_gland0.81595544
115MP0001845_abnormal_inflammatory_respons0.81402585
116MP0003195_calcinosis0.81117675
117MP0004215_abnormal_myocardial_fiber0.80517831
118MP0006292_abnormal_olfactory_placode0.80460088
119MP0001790_abnormal_immune_system0.79845865
120MP0005387_immune_system_phenotype0.79845865
121MP0001764_abnormal_homeostasis0.79587074
122MP0010155_abnormal_intestine_physiology0.79431540
123MP0003448_altered_tumor_morphology0.79356680
124MP0009703_decreased_birth_body0.79142533
125MP0001929_abnormal_gametogenesis0.79000595
126MP0005023_abnormal_wound_healing0.77365256
127MP0001177_atelectasis0.77245541
128MP0006054_spinal_hemorrhage0.76904629
129MP0008872_abnormal_physiological_respon0.72338939
130MP0001881_abnormal_mammary_gland0.71913408
131MP0004197_abnormal_fetal_growth/weight/0.71877227
132MP0005391_vision/eye_phenotype0.71787466
133MP0003943_abnormal_hepatobiliary_system0.71645934
134MP0005075_abnormal_melanosome_morpholog0.70729875
135MP0008469_abnormal_protein_level0.70317957
136MP0002084_abnormal_developmental_patter0.70134370
137MP0006036_abnormal_mitochondrial_physio0.68606703
138MP0005464_abnormal_platelet_physiology0.67773509
139MP0001533_abnormal_skeleton_physiology0.66997344
140MP0003656_abnormal_erythrocyte_physiolo0.66687077
141MP0003315_abnormal_perineum_morphology0.65351041
142MP0000049_abnormal_middle_ear0.65077180
143MP0005394_taste/olfaction_phenotype0.64572816
144MP0005499_abnormal_olfactory_system0.64572816
145MP0002282_abnormal_trachea_morphology0.64481354
146MP0002234_abnormal_pharynx_morphology0.63973783
147MP0003566_abnormal_cell_adhesion0.63574233
148MP0005076_abnormal_cell_differentiation0.63467644
149MP0003936_abnormal_reproductive_system0.62353493
150MP0003698_abnormal_male_reproductive0.62133092
151MP0001485_abnormal_pinna_reflex0.61247918
152MP0005551_abnormal_eye_electrophysiolog0.61109341
153MP0001324_abnormal_eye_pigmentation0.60936108

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.41727407
2Breast hypoplasia (HP:0003187)3.83621114
3Degeneration of anterior horn cells (HP:0002398)3.66851399
4Abnormality of the anterior horn cell (HP:0006802)3.66851399
5Rough bone trabeculation (HP:0100670)3.57522891
6Acute necrotizing encephalopathy (HP:0006965)3.46610450
7Chromsome breakage (HP:0040012)3.45005576
8Acute encephalopathy (HP:0006846)3.33997973
9Abnormality of cells of the erythroid lineage (HP:0012130)3.29456002
10Carpal bone hypoplasia (HP:0001498)3.25189824
11Abnormal number of erythroid precursors (HP:0012131)3.22919898
12Increased hepatocellular lipid droplets (HP:0006565)3.20545126
13Oral leukoplakia (HP:0002745)3.18732518
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.17578016
15Aplastic anemia (HP:0001915)3.15522930
16Increased CSF lactate (HP:0002490)3.09324273
17Reticulocytopenia (HP:0001896)3.06093198
18Abnormal mitochondria in muscle tissue (HP:0008316)3.02334949
19Cerebral hypomyelination (HP:0006808)2.99359905
20Patellar aplasia (HP:0006443)2.92284525
21Mitochondrial inheritance (HP:0001427)2.91533036
22Progressive macrocephaly (HP:0004481)2.88293098
23Lipid accumulation in hepatocytes (HP:0006561)2.85182656
24Abnormality of chromosome stability (HP:0003220)2.83419752
25Abnormality of the preputium (HP:0100587)2.78878605
26Impulsivity (HP:0100710)2.74638828
27Aplasia/Hypoplasia of the patella (HP:0006498)2.73348224
28Meckel diverticulum (HP:0002245)2.71847677
29Bone marrow hypocellularity (HP:0005528)2.71191429
30Abnormal lung lobation (HP:0002101)2.70102053
31Increased serum pyruvate (HP:0003542)2.69076109
32Entropion (HP:0000621)2.67654042
33Agnosia (HP:0010524)2.67054101
34Abnormality of methionine metabolism (HP:0010901)2.64653095
35Abnormal trabecular bone morphology (HP:0100671)2.63829740
36Premature graying of hair (HP:0002216)2.60061257
37Hepatocellular necrosis (HP:0001404)2.55988831
38Multiple enchondromatosis (HP:0005701)2.55055331
39Abnormality of glycolysis (HP:0004366)2.53423823
40Abnormality of the ileum (HP:0001549)2.53083357
41Abnormality of serum amino acid levels (HP:0003112)2.52822807
42Methylmalonic acidemia (HP:0002912)2.52719746
43Thrombocytosis (HP:0001894)2.52276434
44Type I transferrin isoform profile (HP:0003642)2.51686227
45Cerebral edema (HP:0002181)2.48370422
46Irregular epiphyses (HP:0010582)2.47800136
47Trismus (HP:0000211)2.46236714
48Abnormality of alanine metabolism (HP:0010916)2.45466940
49Hyperalaninemia (HP:0003348)2.45466940
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45466940
51Myelodysplasia (HP:0002863)2.44057748
52Nephroblastoma (Wilms tumor) (HP:0002667)2.43646804
53Abnormality of the pons (HP:0007361)2.43639602
54Pallor (HP:0000980)2.42926929
55Hypoplasia of the pons (HP:0012110)2.40775958
56Microretrognathia (HP:0000308)2.40299426
57Embryonal renal neoplasm (HP:0011794)2.36898962
58Macrocytic anemia (HP:0001972)2.36703327
59Ependymoma (HP:0002888)2.36178068
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.35980600
61Rhabdomyosarcoma (HP:0002859)2.35744830
62Abnormal spermatogenesis (HP:0008669)2.35695628
63Poor head control (HP:0002421)2.33233173
64Cleft eyelid (HP:0000625)2.31701220
65Lymphoma (HP:0002665)2.30931904
66Volvulus (HP:0002580)2.29789894
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.29359279
68Selective tooth agenesis (HP:0001592)2.29231189
69Hepatic necrosis (HP:0002605)2.28666584
7011 pairs of ribs (HP:0000878)2.26058014
71Premature ovarian failure (HP:0008209)2.24247211
72Duodenal stenosis (HP:0100867)2.22520481
73Small intestinal stenosis (HP:0012848)2.22520481
74Secondary amenorrhea (HP:0000869)2.21051819
75Cellular immunodeficiency (HP:0005374)2.19956130
76Muscle fiber atrophy (HP:0100295)2.18827182
77IgM deficiency (HP:0002850)2.18083920
78Type 2 muscle fiber atrophy (HP:0003554)2.17176719
79Renal Fanconi syndrome (HP:0001994)2.14461113
80Glossoptosis (HP:0000162)2.14129134
81IgG deficiency (HP:0004315)2.13691214
82Lactic acidosis (HP:0003128)2.13622837
83Glioma (HP:0009733)2.13222457
84Microvesicular hepatic steatosis (HP:0001414)2.12320043
85Pancytopenia (HP:0001876)2.12106378
86Absent thumb (HP:0009777)2.11803788
87Hyperglycinemia (HP:0002154)2.10189778
88Methylmalonic aciduria (HP:0012120)2.09231401
89Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.08232999
90Sparse eyelashes (HP:0000653)2.07297638
91Neoplasm of the pancreas (HP:0002894)2.06088343
92Pancreatic cysts (HP:0001737)2.05826000
93Abnormality of the umbilical cord (HP:0010881)2.04986490
94Megaloblastic anemia (HP:0001889)2.04406610
95Absent radius (HP:0003974)2.01598010
96Amaurosis fugax (HP:0100576)2.00589822
97Triphalangeal thumb (HP:0001199)2.00530578
98Neoplasm of the adrenal gland (HP:0100631)1.99312614
99Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97939394
100Abnormality of the carotid arteries (HP:0005344)1.97801083
101Atrophy/Degeneration involving motor neurons (HP:0007373)1.96621308
102Spinal muscular atrophy (HP:0007269)1.95995624
103Abnormal protein glycosylation (HP:0012346)1.95543946
104Abnormal glycosylation (HP:0012345)1.95543946
105Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95543946
106Abnormal protein N-linked glycosylation (HP:0012347)1.95543946
107Nausea (HP:0002018)1.95417978
108Pulmonary fibrosis (HP:0002206)1.95187642
109Clubbing of toes (HP:0100760)1.94772903
110Posterior subcapsular cataract (HP:0007787)1.93365107
111Recurrent abscess formation (HP:0002722)1.91730226
112Tracheoesophageal fistula (HP:0002575)1.91656564
113Reduced antithrombin III activity (HP:0001976)1.91532107
114Increased serum lactate (HP:0002151)1.91395359
115Sloping forehead (HP:0000340)1.91149044
116Colon cancer (HP:0003003)1.90108263
117Postnatal microcephaly (HP:0005484)1.87393469
118Neoplasm of the colon (HP:0100273)1.87353629
119Abnormality of the labia minora (HP:0012880)1.87285917
120Leukodystrophy (HP:0002415)1.86743458
121Poikiloderma (HP:0001029)1.86599974
122Pancreatic fibrosis (HP:0100732)1.85907734
123Granulocytopenia (HP:0001913)1.84476741
124Aseptic necrosis (HP:0010885)1.84246031
125Slender long bone (HP:0003100)1.84122459
126Horseshoe kidney (HP:0000085)1.83628609
127True hermaphroditism (HP:0010459)1.83596729
128Lethargy (HP:0001254)1.82505656
129Increased IgM level (HP:0003496)1.82154482
130Aplasia involving forearm bones (HP:0009822)1.81917961
131Absent forearm bone (HP:0003953)1.81917961
132Molar tooth sign on MRI (HP:0002419)1.81438554
133Abnormality of midbrain morphology (HP:0002418)1.81438554
134Medulloblastoma (HP:0002885)1.80381934
135Eczematoid dermatitis (HP:0000976)1.80079133
136Petechiae (HP:0000967)1.79858561
137Abnormality of serine family amino acid metabolism (HP:0010894)1.79513610
138Abnormality of glycine metabolism (HP:0010895)1.79513610
139Stillbirth (HP:0003826)1.79386627
1403-Methylglutaconic aciduria (HP:0003535)1.78956002
141Exertional dyspnea (HP:0002875)1.78934236
142Tongue fasciculations (HP:0001308)1.77603419
143Abnormality of T cell physiology (HP:0011840)1.76479740
144Hypoplastic pelvis (HP:0008839)1.76075736
145Respiratory failure (HP:0002878)1.76031427
146Ureteral duplication (HP:0000073)1.74209526
147Congenital, generalized hypertrichosis (HP:0004540)1.74180872
148Abnormality of the duodenum (HP:0002246)1.73904452
149Hyperglycinuria (HP:0003108)1.73717790
150Bifid tongue (HP:0010297)1.73272884
151Abnormality of T cells (HP:0002843)1.73178560
152Flat capital femoral epiphysis (HP:0003370)1.72008962
153Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.71748419
154Absent epiphyses (HP:0010577)1.71748419
155CNS hypomyelination (HP:0003429)1.71646641
156Optic disc pallor (HP:0000543)1.70730720
157Ectopic kidney (HP:0000086)1.69284735
158Exercise intolerance (HP:0003546)1.68457594
159Stenosis of the external auditory canal (HP:0000402)1.68450245
160Decreased activity of mitochondrial respiratory chain (HP:0008972)1.68172786
161Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.68172786

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.60445153
2WEE14.33114649
3EIF2AK13.64506959
4STK163.17115228
5ACVR1B3.04361075
6CDC72.95614967
7NME22.83020522
8EIF2AK32.77396003
9VRK22.61615402
10TRIM282.60346710
11TSSK62.56337981
12BRSK22.47584206
13PLK42.35537766
14SRPK12.33321823
15NEK21.98173148
16NUAK11.87217991
17PIM21.84483611
18PLK11.74034759
19VRK11.72929873
20WNK31.66542654
21PLK31.60749236
22MKNK11.60054637
23TESK21.57496977
24TTK1.50184475
25TAF11.49204702
26NEK11.48641851
27PBK1.47937369
28ZAK1.43021605
29RPS6KA41.35377922
30AURKB1.35238778
31MST41.34316964
32TNIK1.34040594
33CCNB11.33817560
34BRSK11.32039402
35MKNK21.25551257
36CDK71.23213128
37ATR1.23053426
38MAP4K21.22024570
39MAP4K11.19083123
40KDR1.18143814
41EIF2AK21.18109418
42TXK1.14313370
43TGFBR11.12649521
44ERBB31.09269594
45DYRK31.08578195
46RPS6KB21.08339890
47MAP3K121.05921557
48STK101.03050303
49TLK11.01374165
50AURKA0.97664044
51PNCK0.94311812
52PASK0.92091624
53EPHA20.92004415
54CHEK20.90902577
55CDK80.90429906
56TESK10.89824328
57JAK30.88342692
58IRAK40.86602440
59PIM10.86006515
60MAP3K80.85973370
61ZAP700.84689080
62CSNK1G10.84242014
63PLK20.83734138
64SCYL20.82751585
65FRK0.82073817
66CHEK10.80674851
67CDK40.79839362
68MAP3K140.78380670
69ALK0.75823338
70PAK40.74035206
71MAP2K30.73489000
72TYK20.72093243
73BRAF0.71395546
74CSNK1G30.71351721
75STK390.71041931
76AKT30.70075846
77IKBKB0.69407830
78STK40.68514615
79OXSR10.68232387
80ARAF0.68139771
81CSNK2A10.67485940
82KIT0.66842801
83CSNK1G20.64970158
84TEC0.63431341
85MAPKAPK30.63151852
86FLT30.61880400
87ERBB40.61694246
88NME10.61498857
89STK240.61086634
90CSNK2A20.60741919
91IRAK30.60005111
92FGFR10.58843730
93PAK10.57140051
94ABL20.55228828
95CSNK1A1L0.55050133
96GRK10.53874569
97ATM0.53732848
98NEK90.52585095
99STK30.50748336
100MAP3K40.50355049
101NLK0.49884607
102CDK20.48768853
103CDK120.48099989
104MAP3K30.47544393
105DYRK20.46890280
106MAP3K110.45460209
107TBK10.44635036
108BCKDK0.44096489
109CSNK1E0.43097361
110PDK20.43068764
111STK38L0.41579941
112RPS6KA50.40664031
113BTK0.39492537
114BMPR1B0.39100071
115MELK0.38664190
116LRRK20.38615834
117DAPK10.37885882
118MARK30.37027068
119BLK0.36557444
120MAP2K70.36237390
121LYN0.36013558
122CHUK0.35465215
123INSRR0.35143258
124PRKCI0.34550439
125CLK10.34515034
126CDK10.34302110
127SIK30.33518567
128CDK190.33181449
129ADRBK20.32673411
130BCR0.31989596
131TIE10.31934848
132WNK40.30691116
133BRD40.30214956
134PRKDC0.29401378
135CDK30.28766774
136CASK0.26571610
137MINK10.20014545
138PRKCE0.19483609
139CSNK1A10.19401061

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.52408339
2DNA replication_Homo sapiens_hsa030304.05654046
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.99128243
4RNA polymerase_Homo sapiens_hsa030203.66213474
5Mismatch repair_Homo sapiens_hsa034303.35574865
6Ribosome_Homo sapiens_hsa030103.13257745
7RNA transport_Homo sapiens_hsa030132.87719284
8Spliceosome_Homo sapiens_hsa030402.86837033
9Homologous recombination_Homo sapiens_hsa034402.67179749
10Base excision repair_Homo sapiens_hsa034102.49898542
11Pyrimidine metabolism_Homo sapiens_hsa002402.47542877
12Nucleotide excision repair_Homo sapiens_hsa034202.43649898
13Cell cycle_Homo sapiens_hsa041102.25764302
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14456214
15One carbon pool by folate_Homo sapiens_hsa006702.07027244
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.01970824
17Non-homologous end-joining_Homo sapiens_hsa034501.90472830
18Basal transcription factors_Homo sapiens_hsa030221.85443430
19Fanconi anemia pathway_Homo sapiens_hsa034601.82554851
20Propanoate metabolism_Homo sapiens_hsa006401.77507750
21RNA degradation_Homo sapiens_hsa030181.76477230
22p53 signaling pathway_Homo sapiens_hsa041151.62048067
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59276279
24Vitamin B6 metabolism_Homo sapiens_hsa007501.56619539
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45087765
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.39765360
27Purine metabolism_Homo sapiens_hsa002301.37876757
28Steroid biosynthesis_Homo sapiens_hsa001001.37072068
29Epstein-Barr virus infection_Homo sapiens_hsa051691.36596034
30Pyruvate metabolism_Homo sapiens_hsa006201.36472515
31Protein export_Homo sapiens_hsa030601.35873891
32Antigen processing and presentation_Homo sapiens_hsa046121.35265056
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30173311
34Legionellosis_Homo sapiens_hsa051341.23526328
35mRNA surveillance pathway_Homo sapiens_hsa030151.21020423
36Fatty acid elongation_Homo sapiens_hsa000621.20032019
37Allograft rejection_Homo sapiens_hsa053301.18112873
38Herpes simplex infection_Homo sapiens_hsa051681.14028084
39Folate biosynthesis_Homo sapiens_hsa007901.13416894
40Graft-versus-host disease_Homo sapiens_hsa053321.13160135
41Pentose phosphate pathway_Homo sapiens_hsa000301.11093899
42Alzheimers disease_Homo sapiens_hsa050101.08002530
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05327826
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00997531
45NF-kappa B signaling pathway_Homo sapiens_hsa040640.87820377
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.86150960
47Measles_Homo sapiens_hsa051620.83849320
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.82349914
49Primary immunodeficiency_Homo sapiens_hsa053400.79143946
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78254505
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.77836047
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76804813
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76261799
54Systemic lupus erythematosus_Homo sapiens_hsa053220.74720315
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73381074
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73047529
57Viral carcinogenesis_Homo sapiens_hsa052030.72901172
58Butanoate metabolism_Homo sapiens_hsa006500.72875550
59Type I diabetes mellitus_Homo sapiens_hsa049400.70930357
60Selenocompound metabolism_Homo sapiens_hsa004500.70326121
61Sulfur metabolism_Homo sapiens_hsa009200.69680132
62Regulation of autophagy_Homo sapiens_hsa041400.68888687
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68601290
64Leishmaniasis_Homo sapiens_hsa051400.66542290
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65435878
66Peroxisome_Homo sapiens_hsa041460.64764864
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64730443
68Biosynthesis of amino acids_Homo sapiens_hsa012300.63864505
69Apoptosis_Homo sapiens_hsa042100.57971722
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56938945
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56062273
72Influenza A_Homo sapiens_hsa051640.55890174
73Oocyte meiosis_Homo sapiens_hsa041140.55379757
74Asthma_Homo sapiens_hsa053100.52772555
75Hematopoietic cell lineage_Homo sapiens_hsa046400.52208406
76Autoimmune thyroid disease_Homo sapiens_hsa053200.52077314
77Huntingtons disease_Homo sapiens_hsa050160.51647156
78Shigellosis_Homo sapiens_hsa051310.51400979
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48948465
80HTLV-I infection_Homo sapiens_hsa051660.48942866
81TGF-beta signaling pathway_Homo sapiens_hsa043500.48208336
82Phototransduction_Homo sapiens_hsa047440.48125068
83Sulfur relay system_Homo sapiens_hsa041220.47730536
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47209345
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46555369
86Fatty acid metabolism_Homo sapiens_hsa012120.46512550
87Caffeine metabolism_Homo sapiens_hsa002320.45377854
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45102367
89Glutathione metabolism_Homo sapiens_hsa004800.44443555
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41522631
91Fructose and mannose metabolism_Homo sapiens_hsa000510.41374693
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40398292
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39632767
94Hepatitis B_Homo sapiens_hsa051610.39202930
95beta-Alanine metabolism_Homo sapiens_hsa004100.39029858
96Tryptophan metabolism_Homo sapiens_hsa003800.38993296
97Parkinsons disease_Homo sapiens_hsa050120.38643726
98Thyroid cancer_Homo sapiens_hsa052160.36424365
99Carbon metabolism_Homo sapiens_hsa012000.36245055
100Fatty acid degradation_Homo sapiens_hsa000710.34065055
101Small cell lung cancer_Homo sapiens_hsa052220.33074554
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32940127
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31661483
104Cardiac muscle contraction_Homo sapiens_hsa042600.31321750
105Nitrogen metabolism_Homo sapiens_hsa009100.30601106
106Malaria_Homo sapiens_hsa051440.30362451
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29153772
108Rheumatoid arthritis_Homo sapiens_hsa053230.28377042
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28116073
110Oxidative phosphorylation_Homo sapiens_hsa001900.27722569
111Arachidonic acid metabolism_Homo sapiens_hsa005900.27217852
112Pertussis_Homo sapiens_hsa051330.27188189
113Galactose metabolism_Homo sapiens_hsa000520.27158019
114Arginine and proline metabolism_Homo sapiens_hsa003300.27131716
115Retinol metabolism_Homo sapiens_hsa008300.27015073
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26713731
117Renin-angiotensin system_Homo sapiens_hsa046140.26216384
118Metabolic pathways_Homo sapiens_hsa011000.25956416
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25115118
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.24895188
121N-Glycan biosynthesis_Homo sapiens_hsa005100.24492720
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.24422948
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.24326595
124TNF signaling pathway_Homo sapiens_hsa046680.23027619
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21856179
126Other glycan degradation_Homo sapiens_hsa005110.21852681
127Hippo signaling pathway_Homo sapiens_hsa043900.21537371
128Viral myocarditis_Homo sapiens_hsa054160.21161452
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20851219
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20285174
131Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19530724
132Phagosome_Homo sapiens_hsa041450.19506181
133Vitamin digestion and absorption_Homo sapiens_hsa049770.19056699
134HIF-1 signaling pathway_Homo sapiens_hsa040660.18747252
135Chemical carcinogenesis_Homo sapiens_hsa052040.16852686
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.16105124
137Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15808097
138Wnt signaling pathway_Homo sapiens_hsa043100.14920396
139Hedgehog signaling pathway_Homo sapiens_hsa043400.12250947
140Basal cell carcinoma_Homo sapiens_hsa052170.12183339
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12123670
142Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.07911074
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.07692520
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.06435753
145Lysine degradation_Homo sapiens_hsa003100.06317258

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