DCAF12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.50695204
2regulation of B cell receptor signaling pathway (GO:0050855)5.65074267
3microglial cell activation (GO:0001774)5.54842324
4negative regulation of cell killing (GO:0031342)5.49400739
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.49400739
6positive regulation by symbiont of host defense response (GO:0052509)5.27472566
7modulation by symbiont of host defense response (GO:0052031)5.27472566
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.27472566
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.27472566
10positive regulation by organism of defense response of other organism involved in symbiotic interact5.27472566
11modulation by symbiont of host immune response (GO:0052553)5.27472566
12detection of molecule of bacterial origin (GO:0032490)5.24990900
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.78260894
14regulation of gamma-delta T cell differentiation (GO:0045586)4.60193702
15regulation of gamma-delta T cell activation (GO:0046643)4.57787300
16negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.52494689
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.45743895
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.42179959
19positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.37250258
20macrophage activation involved in immune response (GO:0002281)4.30117013
21protein localization to chromosome, centromeric region (GO:0071459)4.22755505
22macrophage activation (GO:0042116)4.20045009
23protein localization to kinetochore (GO:0034501)4.06913183
24negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)4.04620311
25regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.03976740
26positive regulation of granulocyte differentiation (GO:0030854)4.00000420
27B cell receptor signaling pathway (GO:0050853)3.99765466
28positive T cell selection (GO:0043368)3.98535801
29mitotic chromosome condensation (GO:0007076)3.97905076
30positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.96787889
31detection of external biotic stimulus (GO:0098581)3.95111492
32neutrophil mediated immunity (GO:0002446)3.94025468
33positive thymic T cell selection (GO:0045059)3.93874191
34cellular extravasation (GO:0045123)3.93105675
35mitotic nuclear envelope disassembly (GO:0007077)3.93068140
36regulation of necroptotic process (GO:0060544)3.91994025
37negative T cell selection (GO:0043383)3.89226614
38histone H3-K36 demethylation (GO:0070544)3.84197232
39mitotic metaphase plate congression (GO:0007080)3.79115224
40DNA replication-dependent nucleosome organization (GO:0034723)3.77744671
41DNA replication-dependent nucleosome assembly (GO:0006335)3.77744671
42protoporphyrinogen IX metabolic process (GO:0046501)3.77742671
43negative thymic T cell selection (GO:0045060)3.77633953
44response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.77490998
45response to host immune response (GO:0052572)3.77490998
46phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.76572433
47positive regulation of receptor recycling (GO:0001921)3.74479321
48positive regulation of insulin receptor signaling pathway (GO:0046628)3.74089659
49mitotic sister chromatid segregation (GO:0000070)3.73623604
50membrane disassembly (GO:0030397)3.73224958
51nuclear envelope disassembly (GO:0051081)3.73224958
52negative regulation of lymphocyte mediated immunity (GO:0002707)3.71397787
53neutrophil activation involved in immune response (GO:0002283)3.69936285
54myeloid leukocyte mediated immunity (GO:0002444)3.68901862
55negative regulation of T cell mediated immunity (GO:0002710)3.65953714
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.61447945
57detection of other organism (GO:0098543)3.59034605
58antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.54956563
59response to host defenses (GO:0052200)3.52063700
60response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.52063700
61response to host (GO:0075136)3.52063700
62erythrocyte development (GO:0048821)3.50432062
63regulation of platelet aggregation (GO:0090330)3.50103417
64dosage compensation (GO:0007549)3.50068181
65regulation of spindle organization (GO:0090224)3.45402139
663-UTR-mediated mRNA stabilization (GO:0070935)3.44611809
67positive regulation of chromosome segregation (GO:0051984)3.39322751
68detection of biotic stimulus (GO:0009595)3.36893091
69regulation of interferon-beta biosynthetic process (GO:0045357)3.35960032
70DNA replication checkpoint (GO:0000076)3.35683261
71sister chromatid segregation (GO:0000819)3.35587300
72negative regulation of B cell proliferation (GO:0030889)3.33430806
73response to interleukin-15 (GO:0070672)3.32912585
74antigen processing and presentation of endogenous antigen (GO:0019883)3.32357339
75negative regulation of histone methylation (GO:0031061)3.32058366
76negative regulation of interleukin-12 production (GO:0032695)3.32003321
77regulation of B cell differentiation (GO:0045577)3.27630799
78DNA unwinding involved in DNA replication (GO:0006268)3.27277726
79DNA replication initiation (GO:0006270)3.27179637
80protein localization to chromosome (GO:0034502)3.24579818
81regulation of beta-amyloid formation (GO:1902003)3.22357551
82positive regulation of B cell differentiation (GO:0045579)3.21372660
83oxygen transport (GO:0015671)3.19778777
84respiratory burst (GO:0045730)3.18995214
85DNA strand elongation involved in DNA replication (GO:0006271)3.18664184
86negative regulation of necroptotic process (GO:0060546)3.18627954
87monoubiquitinated protein deubiquitination (GO:0035520)3.15547258
88myeloid cell activation involved in immune response (GO:0002275)3.15412289
89attachment of spindle microtubules to kinetochore (GO:0008608)3.14475051
90protein K11-linked deubiquitination (GO:0035871)3.12109610
91mitotic sister chromatid cohesion (GO:0007064)3.11389152
92nuclear envelope organization (GO:0006998)3.11290215
93myeloid cell development (GO:0061515)3.10956784
94regulation of chromosome segregation (GO:0051983)3.09316051
95negative regulation of leukocyte mediated immunity (GO:0002704)3.08631413
96hemoglobin metabolic process (GO:0020027)3.08607558
97maturation of 5.8S rRNA (GO:0000460)3.05539168
98metaphase plate congression (GO:0051310)3.05239319
99positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.04796943
100mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.04796943
101T cell selection (GO:0045058)3.04692418
102antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.04029935
103detection of bacterium (GO:0016045)3.03319050
104protoporphyrinogen IX biosynthetic process (GO:0006782)3.02192524
105establishment of chromosome localization (GO:0051303)3.01960350
106negative regulation of glial cell proliferation (GO:0060253)3.01503645
107negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.00598083
108leukocyte aggregation (GO:0070486)3.00561048
109regulation of amyloid precursor protein catabolic process (GO:1902991)3.00559031
110DNA strand elongation (GO:0022616)3.00541722
111activated T cell proliferation (GO:0050798)2.97501200
112chromatin assembly or disassembly (GO:0006333)2.95475889
113chromosome condensation (GO:0030261)2.92277171
114T cell migration (GO:0072678)2.87819798
115cellular response to virus (GO:0098586)2.87333290
116nuclear pore organization (GO:0006999)2.86157383
117regulation of mitotic spindle organization (GO:0060236)2.85659264
118neutrophil activation (GO:0042119)2.85647548
119folic acid-containing compound biosynthetic process (GO:0009396)2.85294938
120DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.85196566
121DNA replication-independent nucleosome assembly (GO:0006336)2.84802153
122DNA replication-independent nucleosome organization (GO:0034724)2.84802153
123positive regulation of mitotic sister chromatid separation (GO:1901970)2.84746524
124positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.84746524
125positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.84746524
126response to peptidoglycan (GO:0032494)2.84683777
127chromosome segregation (GO:0007059)2.83970369
128negative regulation of immunoglobulin mediated immune response (GO:0002890)2.83535830
129negative regulation of B cell mediated immunity (GO:0002713)2.83535830
130gene silencing by RNA (GO:0031047)2.83126905
131histone H2A monoubiquitination (GO:0035518)2.81496122
132regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.81298586
133positive regulation of response to oxidative stress (GO:1902884)2.81053929
134positive regulation of cellular response to oxidative stress (GO:1900409)2.81053929
135regulation of histone H3-K27 methylation (GO:0061085)2.80980107
136regulation of sister chromatid cohesion (GO:0007063)2.80410170
137regulation of granulocyte differentiation (GO:0030852)2.80358922
138regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.78959047
139negative regulation of adaptive immune response (GO:0002820)2.78569500
140cellular response to interleukin-15 (GO:0071350)2.77690517
141nuclear pore complex assembly (GO:0051292)2.76969771
142regulation of glial cell proliferation (GO:0060251)2.76899090
143regulation of double-strand break repair via homologous recombination (GO:0010569)2.75229914
144thymic T cell selection (GO:0045061)2.74898080
145megakaryocyte development (GO:0035855)2.74593003
146piRNA metabolic process (GO:0034587)2.73456856
147negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.72960082
148DNA damage response, signal transduction resulting in transcription (GO:0042772)2.72809635
149regulation of cellular amide metabolic process (GO:0034248)2.71841987
150negative regulation of execution phase of apoptosis (GO:1900118)2.71458493
151regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.71153074
152negative regulation of chromosome segregation (GO:0051985)2.70380634
153regulation of exit from mitosis (GO:0007096)2.67290346
154histone mRNA catabolic process (GO:0071044)2.67103507
155spindle checkpoint (GO:0031577)2.65204778
156regulation of mitotic metaphase/anaphase transition (GO:0030071)2.63575669
157negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.63141251
158negative regulation of sister chromatid segregation (GO:0033046)2.63141251
159negative regulation of mitotic sister chromatid separation (GO:2000816)2.63141251
160negative regulation of mitotic sister chromatid segregation (GO:0033048)2.63141251
161regulation of translational termination (GO:0006449)2.62796477
162mRNA stabilization (GO:0048255)2.62251766
163RNA stabilization (GO:0043489)2.62251766
164somatic diversification of immune receptors via somatic mutation (GO:0002566)2.62142472
165somatic hypermutation of immunoglobulin genes (GO:0016446)2.62142472
166Arp2/3 complex-mediated actin nucleation (GO:0034314)2.61070376
167translesion synthesis (GO:0019985)2.60347122
168porphyrin-containing compound biosynthetic process (GO:0006779)2.60292578
169pre-miRNA processing (GO:0031054)2.60231358
170telomere maintenance via semi-conservative replication (GO:0032201)2.57423685
171mitotic spindle assembly checkpoint (GO:0007094)2.56775864
172meiotic cell cycle (GO:0051321)2.56321083
173regulation of histone H3-K9 methylation (GO:0051570)2.55903660
174spindle assembly checkpoint (GO:0071173)2.54966979
175histone exchange (GO:0043486)2.54649232
176immunoglobulin mediated immune response (GO:0016064)2.53173276
177negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.53130239
178CENP-A containing nucleosome assembly (GO:0034080)2.51913542
179mitotic spindle checkpoint (GO:0071174)2.51210434
180erythrocyte maturation (GO:0043249)2.49837114
181protein K6-linked ubiquitination (GO:0085020)2.49290349
182formation of translation preinitiation complex (GO:0001731)2.49195917
183heme biosynthetic process (GO:0006783)2.47709938
184DNA packaging (GO:0006323)2.47296419
185chromatin assembly (GO:0031497)2.46513818
186chromatin remodeling at centromere (GO:0031055)2.46495381
187histone H2A ubiquitination (GO:0033522)2.45629753
188B cell mediated immunity (GO:0019724)2.44162250
189mitotic G1 DNA damage checkpoint (GO:0031571)2.44085877
190meiotic chromosome segregation (GO:0045132)2.41425814
191regulation of sister chromatid segregation (GO:0033045)2.41378804
192regulation of mitotic sister chromatid separation (GO:0010965)2.41378804
193regulation of mitotic sister chromatid segregation (GO:0033047)2.41378804
194hepatocyte apoptotic process (GO:0097284)2.40900395
195protein complex localization (GO:0031503)2.37689922

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.16534589
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.09520068
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.83285256
4GATA1_22025678_ChIP-Seq_K562_Human3.55125164
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.33732545
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.21313847
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.02309660
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.99828156
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.98367432
10RUNX_20019798_ChIP-Seq_JUKART_Human2.97350441
11GATA1_19941826_ChIP-Seq_K562_Human2.88784766
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.87263284
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.86471489
14MYC_22102868_ChIP-Seq_BL_Human2.79236202
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.63302656
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.39543573
17SPI1_23127762_ChIP-Seq_K562_Human2.36980038
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.35834777
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.34465746
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.31960013
21GATA1_19941827_ChIP-Seq_MEL_Mouse2.31382126
22GATA2_19941826_ChIP-Seq_K562_Human2.25553030
23VDR_21846776_ChIP-Seq_THP-1_Human2.04763638
24AR_21909140_ChIP-Seq_LNCAP_Human1.97189257
25GATA3_27048872_Chip-Seq_THYMUS_Human1.91024297
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.87157671
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75806207
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.74799232
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.74364515
30GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.74126551
31PU_27001747_Chip-Seq_BMDM_Mouse1.72357797
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.70748433
33* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67861069
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65719016
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65090485
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64721655
37VDR_24787735_ChIP-Seq_THP-1_Human1.58931919
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58819818
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57299319
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57229995
41SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53089084
42* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52693019
43KLF4_18555785_ChIP-Seq_MESCs_Mouse1.51293911
44KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.50878847
45TCF7_22412390_ChIP-Seq_EML_Mouse1.49251521
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48087903
47CIITA_25753668_ChIP-Seq_RAJI_Human1.45055851
48XRN2_22483619_ChIP-Seq_HELA_Human1.44373811
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42547584
50MAF_26560356_Chip-Seq_TH1_Human1.40575037
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.40003006
52UTX_26944678_Chip-Seq_JUKART_Human1.39322486
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.39009859
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38859718
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38830471
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38397772
57KDM5A_27292631_Chip-Seq_BREAST_Human1.37512157
58ZNF263_19887448_ChIP-Seq_K562_Human1.36614619
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.36578372
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36493950
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34574347
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31908247
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29532997
64SCL_19346495_ChIP-Seq_HPC-7_Human1.29305706
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29293058
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28964192
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28777881
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27791406
69GABP_19822575_ChIP-Seq_HepG2_Human1.27385694
70GATA3_26560356_Chip-Seq_TH2_Human1.27047962
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.25948581
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.25814685
73* MYB_26560356_Chip-Seq_TH2_Human1.24354222
74ETS1_20019798_ChIP-Seq_JURKAT_Human1.23908450
75* SPI1_23547873_ChIP-Seq_NB4_Human1.23752124
76ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23579110
77VDR_23849224_ChIP-Seq_CD4+_Human1.23374283
78* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22345362
79KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21857096
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21665106
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21634808
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20926170
83TFEB_21752829_ChIP-Seq_HELA_Human1.20077034
84RUNX1_22412390_ChIP-Seq_EML_Mouse1.19715300
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19464101
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.18887137
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18090477
88FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.17573152
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17428732
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17118398
91* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16146580
92* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.14786610
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14583238
94E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13198424
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13000554
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12872531
97KDM2B_26808549_Chip-Seq_DND41_Human1.12193982
98IRF8_22096565_ChIP-ChIP_GC-B_Human1.12072179
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11929034
100* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10749908
101CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10562597
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10195822
103* MYB_26560356_Chip-Seq_TH1_Human1.10015051
104PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09674262
105* VDR_24763502_ChIP-Seq_THP-1_Human1.09667854
106HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09650626
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09618512
108ATF3_27146783_Chip-Seq_COLON_Human1.09127182
109ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08984716
110GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07755024
111PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07188937
112DCP1A_22483619_ChIP-Seq_HELA_Human1.06651058
113CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06006449
114* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05286135
115FOXP3_21729870_ChIP-Seq_TREG_Human1.04888261
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04378052
117NCOR1_26117541_ChIP-Seq_K562_Human1.03912906
118RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03895914
119GABP_17652178_ChIP-ChIP_JURKAT_Human1.02766570
120KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02113115
121MAF_26560356_Chip-Seq_TH2_Human1.01914360
122NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01432234
123GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01399326
124EST1_17652178_ChIP-ChIP_JURKAT_Human1.00446117
125ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98341373
126NANOG_21062744_ChIP-ChIP_HESCs_Human0.98325938
127IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98000870
128TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97148954
129CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97107198
130TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96678317
131KDM2B_26808549_Chip-Seq_JURKAT_Human0.96565387
132* IRF8_27001747_Chip-Seq_BMDM_Mouse0.95046569
133JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94414403
134LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94181158
135GATA2_21666600_ChIP-Seq_HMVEC_Human0.93952245
136STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.93690836
137CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.92740147
138CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92249701
139RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90963149
140* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.90550064
141TTF2_22483619_ChIP-Seq_HELA_Human0.89375717
142* SMRT_27268052_Chip-Seq_Bcells_Human0.86187947
143RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82677294
144CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82580027
145PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82572195
146SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79932888
147CHD1_26751641_Chip-Seq_LNCaP_Human0.79536441
148TP53_16413492_ChIP-PET_HCT116_Human0.79334360
149GATA3_26560356_Chip-Seq_TH1_Human0.78878944
150SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.76651181
151SALL4_22934838_ChIP-ChIP_CD34+_Human0.75658499
152* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75375938
153FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75342900
154CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74193889
155DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.73742076
156* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73315833

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008260_abnormal_autophagy5.26775726
2MP0000569_abnormal_digit_pigmentation4.22262232
3MP0003111_abnormal_nucleus_morphology3.63086501
4MP0003693_abnormal_embryo_hatching3.60906435
5MP0010094_abnormal_chromosome_stability3.27626082
6MP0003724_increased_susceptibility_to3.08567604
7MP0003077_abnormal_cell_cycle3.07791791
8MP0003656_abnormal_erythrocyte_physiolo3.07263917
9MP0004957_abnormal_blastocyst_morpholog2.88077731
10MP0004381_abnormal_hair_follicle2.51409317
11MP0010352_gastrointestinal_tract_polyps2.46119837
12MP0003172_abnormal_lysosome_physiology2.35635001
13MP0003705_abnormal_hypodermis_morpholog2.12249104
14MP0003303_peritoneal_inflammation2.10440892
15MP0008007_abnormal_cellular_replicative2.10391221
16MP0000015_abnormal_ear_pigmentation2.01195453
17MP0000350_abnormal_cell_proliferation2.00388985
18MP0001730_embryonic_growth_arrest1.98710119
19MP0002396_abnormal_hematopoietic_system1.96246505
20MP0004883_abnormal_blood_vessel1.95107522
21MP0003787_abnormal_imprinting1.95029483
22MP0010307_abnormal_tumor_latency1.93240079
23MP0001545_abnormal_hematopoietic_system1.89617754
24MP0005397_hematopoietic_system_phenotyp1.89617754
25MP0005075_abnormal_melanosome_morpholog1.85535931
26MP0000685_abnormal_immune_system1.76646290
27MP0005076_abnormal_cell_differentiation1.76100520
28MP0002398_abnormal_bone_marrow1.73006109
29MP0009278_abnormal_bone_marrow1.70127037
30MP0005174_abnormal_tail_pigmentation1.69402522
31MP0000490_abnormal_crypts_of1.68029634
32MP0005310_abnormal_salivary_gland1.67487159
33MP0004808_abnormal_hematopoietic_stem1.63641038
34MP0010234_abnormal_vibrissa_follicle1.63250336
35MP0002019_abnormal_tumor_incidence1.62943993
36MP0003436_decreased_susceptibility_to1.59053143
37MP0009333_abnormal_splenocyte_physiolog1.57113262
38MP0001835_abnormal_antigen_presentation1.56874092
39MP0003828_pulmonary_edema1.56632374
40MP0002332_abnormal_exercise_endurance1.56083434
41MP0005083_abnormal_biliary_tract1.49315884
42MP0003300_gastrointestinal_ulcer1.49223602
43MP0001697_abnormal_embryo_size1.47616138
44MP0000689_abnormal_spleen_morphology1.47116122
45MP0008057_abnormal_DNA_replication1.46395630
46MP0001800_abnormal_humoral_immune1.46162127
47MP0002722_abnormal_immune_system1.46137761
48MP0002653_abnormal_ependyma_morphology1.45871076
49MP0000858_altered_metastatic_potential1.45682770
50MP0003191_abnormal_cellular_cholesterol1.41303872
51MP0003183_abnormal_peptide_metabolism1.40712153
52MP0008877_abnormal_DNA_methylation1.40324183
53MP0003763_abnormal_thymus_physiology1.39925795
54MP0005451_abnormal_body_composition1.39566637
55MP0003866_abnormal_defecation1.38271723
56MP0002452_abnormal_antigen_presenting1.37998503
57MP0001672_abnormal_embryogenesis/_devel1.33956516
58MP0005380_embryogenesis_phenotype1.33956516
59MP0005023_abnormal_wound_healing1.32779510
60MP0002429_abnormal_blood_cell1.32571235
61MP0002086_abnormal_extraembryonic_tissu1.30361874
62MP0002080_prenatal_lethality1.29782504
63MP0008932_abnormal_embryonic_tissue1.29505186
64MP0002132_abnormal_respiratory_system1.29351627
65MP0008058_abnormal_DNA_repair1.29135286
66MP0003123_paternal_imprinting1.29116223
67MP0000716_abnormal_immune_system1.27677440
68MP0002420_abnormal_adaptive_immunity1.26241491
69MP0001819_abnormal_immune_cell1.25199269
70MP0001929_abnormal_gametogenesis1.24792117
71MP0003984_embryonic_growth_retardation1.24060030
72MP0003566_abnormal_cell_adhesion1.23054936
73MP0002088_abnormal_embryonic_growth/wei1.22160090
74MP0003221_abnormal_cardiomyocyte_apopto1.22023460
75MP0004264_abnormal_extraembryonic_tissu1.20679779
76MP0000313_abnormal_cell_death1.20183595
77MP0002085_abnormal_embryonic_tissue1.20047166
78MP0000703_abnormal_thymus_morphology1.19624202
79MP0005164_abnormal_response_to1.18618266
80MP0006054_spinal_hemorrhage1.18494295
81MP0002084_abnormal_developmental_patter1.15316536
82MP0002405_respiratory_system_inflammati1.14654273
83MP0003718_maternal_effect1.13617167
84MP0002723_abnormal_immune_serum1.12181560
85MP0005000_abnormal_immune_tolerance1.11744626
86MP0005464_abnormal_platelet_physiology1.11313724
87MP0001849_ear_inflammation1.07683052
88MP0001915_intracranial_hemorrhage1.07243148
89MP0004947_skin_inflammation1.07235398
90MP0009840_abnormal_foam_cell1.07087582
91MP0002210_abnormal_sex_determination1.06228036
92MP0009785_altered_susceptibility_to1.05633528
93MP0002009_preneoplasia1.05628589
94MP0001851_eye_inflammation1.05455292
95MP0005025_abnormal_response_to1.04560157
96MP0004484_altered_response_of1.04398701
97MP0005387_immune_system_phenotype1.04379717
98MP0001790_abnormal_immune_system1.04379717
99MP0002419_abnormal_innate_immunity1.03811358
100MP0003091_abnormal_cell_migration1.01365153
101MP0000465_gastrointestinal_hemorrhage1.01268855
102MP0003646_muscle_fatigue1.00079250
103MP0003690_abnormal_glial_cell0.99843890
104MP0002148_abnormal_hypersensitivity_rea0.99621755
105MP0008995_early_reproductive_senescence0.99551880
106MP0003448_altered_tumor_morphology0.99296403
107MP0002006_tumorigenesis0.98225341
108MP0005621_abnormal_cell_physiology0.96321258
109MP0003453_abnormal_keratinocyte_physiol0.94681773
110MP0004185_abnormal_adipocyte_glucose0.94055399
111MP0001145_abnormal_male_reproductive0.93630171
112MP0000653_abnormal_sex_gland0.93615219
113MP0010155_abnormal_intestine_physiology0.92807498
114MP0002166_altered_tumor_susceptibility0.91908743
115MP0001119_abnormal_female_reproductive0.90718877
116MP0000371_diluted_coat_color0.89100623
117MP0005671_abnormal_response_to0.88879925
118MP0004197_abnormal_fetal_growth/weight/0.87830549
119MP0000604_amyloidosis0.86707606
120MP0001845_abnormal_inflammatory_respons0.86232088
121MP0003329_amyloid_beta_deposits0.85110278
122MP0001873_stomach_inflammation0.83742690
123MP0000733_abnormal_muscle_development0.82208832
124MP0005410_abnormal_fertilization0.81784414
125MP0006082_CNS_inflammation0.81713648
126MP0001533_abnormal_skeleton_physiology0.81195026
127MP0004130_abnormal_muscle_cell0.80297016
128MP0005384_cellular_phenotype0.80021415
129MP0003699_abnormal_female_reproductive0.79931328
130MP0004147_increased_porphyrin_level0.79137107
131MP0009764_decreased_sensitivity_to0.78082085
132MP0000477_abnormal_intestine_morphology0.76235529
133MP0003121_genomic_imprinting0.76013665
134MP0009765_abnormal_xenobiotic_induced0.75961263
135MP0005376_homeostasis/metabolism_phenot0.75820065
136MP0002877_abnormal_melanocyte_morpholog0.75649504
137MP0009763_increased_sensitivity_to0.73903413
138MP0008874_decreased_physiological_sensi0.73576324
139MP0008469_abnormal_protein_level0.73534830
140MP0003632_abnormal_nervous_system0.66221511
141MP0005409_darkened_coat_color0.66149581
142MP0005266_abnormal_metabolism0.66038552
143MP0006035_abnormal_mitochondrial_morpho0.64748910
144MP0001663_abnormal_digestive_system0.63744094
145MP0001958_emphysema0.62766263
146MP0005408_hypopigmentation0.60815417

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)7.38325763
2T lymphocytopenia (HP:0005403)4.91373952
3Abnormality of T cell number (HP:0011839)4.50141358
4Slow saccadic eye movements (HP:0000514)4.09563860
5Gastrointestinal infarctions (HP:0005244)4.08234336
6Gingival bleeding (HP:0000225)3.93178124
7Poikilocytosis (HP:0004447)3.79479288
8Orchitis (HP:0100796)3.78603147
9Retrobulbar optic neuritis (HP:0100654)3.76455497
10Optic neuritis (HP:0100653)3.76455497
11Recurrent skin infections (HP:0001581)3.62178207
12Gingivitis (HP:0000230)3.48731248
13Spontaneous hematomas (HP:0007420)3.46416774
14Eczematoid dermatitis (HP:0000976)3.45055520
15Birth length less than 3rd percentile (HP:0003561)3.27791717
16Postural instability (HP:0002172)3.22049693
17Subacute progressive viral hepatitis (HP:0006572)3.18828102
18Visual hallucinations (HP:0002367)3.16535190
19Peritonitis (HP:0002586)3.16135307
20Prolonged bleeding time (HP:0003010)3.16072577
21Autoimmune thrombocytopenia (HP:0001973)3.13247536
22Pustule (HP:0200039)3.11754476
23Male infertility (HP:0003251)3.09100195
24Chronic mucocutaneous candidiasis (HP:0002728)3.07215873
25Recurrent cutaneous fungal infections (HP:0011370)3.07215873
26Abnormality of macrophages (HP:0004311)3.06028174
27Abnormal delayed hypersensitivity skin test (HP:0002963)3.02801564
28Keratoconjunctivitis sicca (HP:0001097)2.97307402
29Abnormality of T cells (HP:0002843)2.96583793
30Breast hypoplasia (HP:0003187)2.96102399
31Orthostatic hypotension (HP:0001278)2.93548812
32Arterial thrombosis (HP:0004420)2.93097243
33Epistaxis (HP:0000421)2.91151549
34Facial hemangioma (HP:0000329)2.86104371
35Stomatitis (HP:0010280)2.85222063
36Cellulitis (HP:0100658)2.83786442
37Nasal polyposis (HP:0100582)2.82452557
38Meningitis (HP:0001287)2.80466410
39Viral hepatitis (HP:0006562)2.76207199
40Chest pain (HP:0100749)2.74683367
41Encephalitis (HP:0002383)2.73117955
42Papillary thyroid carcinoma (HP:0002895)2.73009213
43Keratoconjunctivitis (HP:0001096)2.67661265
44Vasculitis (HP:0002633)2.63700198
45Chronic obstructive pulmonary disease (HP:0006510)2.63386886
46Obstructive lung disease (HP:0006536)2.63386886
47Abnormality of the heme biosynthetic pathway (HP:0010472)2.61403450
48Heterotopia (HP:0002282)2.58393030
49Periodontitis (HP:0000704)2.52551811
50Cholelithiasis (HP:0001081)2.52386192
51Inflammation of the large intestine (HP:0002037)2.51441319
52Multiple enchondromatosis (HP:0005701)2.50966890
53Cortical dysplasia (HP:0002539)2.50341073
54Recurrent abscess formation (HP:0002722)2.50219522
55Resting tremor (HP:0002322)2.49220307
56Gastrointestinal inflammation (HP:0004386)2.41992191
57Basal cell carcinoma (HP:0002671)2.40983839
58Abnormality of the nasal mucosa (HP:0000433)2.40843172
59High pitched voice (HP:0001620)2.40830143
60Acanthocytosis (HP:0001927)2.39799933
61Polycythemia (HP:0001901)2.39520396
62Prominent nose (HP:0000448)2.39491068
63Recurrent bacterial skin infections (HP:0005406)2.38012264
64Selective tooth agenesis (HP:0001592)2.36304348
65Recurrent viral infections (HP:0004429)2.34890943
66Overlapping toe (HP:0001845)2.34080938
67Patellar aplasia (HP:0006443)2.33935556
68Eosinophilia (HP:0001880)2.32719196
69Recurrent bronchitis (HP:0002837)2.32138872
70Hypoplasia of the capital femoral epiphysis (HP:0003090)2.31661508
71Granulocytopenia (HP:0001913)2.30785586
72Abnormal platelet volume (HP:0011876)2.29378472
73Agnosia (HP:0010524)2.28709515
74Hypoplasia of the thymus (HP:0000778)2.28483971
75Oral leukoplakia (HP:0002745)2.27499671
76Thrombocytosis (HP:0001894)2.23152887
77Conjunctival telangiectasia (HP:0000524)2.22991325
78Petechiae (HP:0000967)2.22300791
79Cerebral inclusion bodies (HP:0100314)2.21853900
80Reticulocytosis (HP:0001923)2.21804503
81Acute hepatic failure (HP:0006554)2.19193139
82Abnormality of the peritoneum (HP:0002585)2.19128923
83Abnormal gallbladder morphology (HP:0012437)2.18192814
84Aplasia/Hypoplasia of the patella (HP:0006498)2.17045687
85Abnormality of the vasculature of the conjunctiva (HP:0008054)2.16625099
86Autoimmune hemolytic anemia (HP:0001890)2.13924921
87Anorexia (HP:0002039)2.12932243
88Premature ovarian failure (HP:0008209)2.12377275
89Bicuspid aortic valve (HP:0001647)2.11960087
90Ependymoma (HP:0002888)2.10904143
91Recurrent fungal infections (HP:0002841)2.10174090
92Hypochromic anemia (HP:0001931)2.08669859
93Abnormality of the anterior horn cell (HP:0006802)2.07614551
94Degeneration of anterior horn cells (HP:0002398)2.07614551
95Disinhibition (HP:0000734)2.05252691
96Osteomyelitis (HP:0002754)2.01435090
97Dysautonomia (HP:0002459)2.00305791
98Increased mean platelet volume (HP:0011877)1.99697638
99Abnormality of the fingertips (HP:0001211)1.99534383
100Urticaria (HP:0001025)1.99371089
101Myositis (HP:0100614)1.99120240
102Hemoptysis (HP:0002105)1.98740047
103Myelodysplasia (HP:0002863)1.97448149
104Cutaneous melanoma (HP:0012056)1.96858477
105Abnormality of eosinophils (HP:0001879)1.96834604
106Secondary amenorrhea (HP:0000869)1.96188354
107IgM deficiency (HP:0002850)1.95393720
108Protrusio acetabuli (HP:0003179)1.95297992
109Hyperacusis (HP:0010780)1.94046346
110Bronchitis (HP:0012387)1.91741156
111Panhypogammaglobulinemia (HP:0003139)1.91718768
112Acute myeloid leukemia (HP:0004808)1.91459664
113Squamous cell carcinoma (HP:0002860)1.91425860
114Carpal bone hypoplasia (HP:0001498)1.91109495
115Rhabdomyosarcoma (HP:0002859)1.90794361
116Hypochromic microcytic anemia (HP:0004840)1.90482060
117Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.89753951
118Aortic aneurysm (HP:0004942)1.89546954
119Broad palm (HP:0001169)1.89064095
120Abnormality of reticulocytes (HP:0004312)1.88995688
121Personality changes (HP:0000751)1.88406591
122Colon cancer (HP:0003003)1.87994931
123Episodic fever (HP:0001954)1.87947779
124Pulmonary embolism (HP:0002204)1.87567616
125IgA deficiency (HP:0002720)1.84791257
126Verrucae (HP:0200043)1.84513141
127Papilloma (HP:0012740)1.84513141
128Chronic otitis media (HP:0000389)1.84227020
129Pelvic girdle muscle weakness (HP:0003749)1.83998900
130Micronodular cirrhosis (HP:0001413)1.83729545
131Pulmonary infiltrates (HP:0002113)1.83267517
132Toxemia of pregnancy (HP:0100603)1.81669288
133Aplasia/Hypoplasia of the thymus (HP:0010515)1.81154466
134Leukocytosis (HP:0001974)1.81142911
135Cafe-au-lait spot (HP:0000957)1.78804945
136Mediastinal lymphadenopathy (HP:0100721)1.78765134
137Spondylolisthesis (HP:0003302)1.77814942
138Thyroid carcinoma (HP:0002890)1.77354332
139Increased nuchal translucency (HP:0010880)1.77283171
140Abnormality of cells of the lymphoid lineage (HP:0012140)1.77048957
141Recurrent gram-negative bacterial infections (HP:0005420)1.75670662
142Ankle contracture (HP:0006466)1.74791513
143Amaurosis fugax (HP:0100576)1.74289941
144Elevated erythrocyte sedimentation rate (HP:0003565)1.72843547
145Poor head control (HP:0002421)1.72001602
146Insomnia (HP:0100785)1.71310169
147Upper motor neuron abnormality (HP:0002127)1.71231105
148Emphysema (HP:0002097)1.71096400
149Microcytic anemia (HP:0001935)1.70613545
150Short 4th metacarpal (HP:0010044)1.70323519
151Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.70323519
152Absent epiphyses (HP:0010577)1.69744449
153Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.69744449
154Genu recurvatum (HP:0002816)1.68942325
155Osteolytic defects of the hand bones (HP:0009699)1.68777354
156Osteolytic defects of the phalanges of the hand (HP:0009771)1.68777354
157Microretrognathia (HP:0000308)1.67552646
158Colitis (HP:0002583)1.67436379
159Lymphoma (HP:0002665)1.66091155
160Cutaneous photosensitivity (HP:0000992)1.65790285
161Trismus (HP:0000211)1.65572802
162Agammaglobulinemia (HP:0004432)1.65004270
163Pulmonary fibrosis (HP:0002206)1.63948911
164Lymphopenia (HP:0001888)1.63240664
165Fatigue (HP:0012378)1.62621883
166Deviation of the thumb (HP:0009603)1.62494105
167Entropion (HP:0000621)1.62229716
168Neoplasm of the pancreas (HP:0002894)1.61901116

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.18255696
2RIPK43.87971909
3FGR2.89145527
4EIF2AK12.87994488
5CDC72.76759478
6STK102.73839227
7TRIB32.65865695
8NEK22.63074821
9MAPKAPK32.61617050
10TESK22.42408620
11IKBKE2.37072644
12CDK122.27395635
13PKN22.22890340
14BUB12.18093191
15WEE12.14923303
16IRAK42.07835845
17PTK2B1.95492045
18TAOK11.95277887
19TTK1.89127293
20SGK21.85459437
21MAP4K11.81176711
22MAP3K101.80031706
23WNK11.76508998
24FES1.75139006
25GRK51.74827703
26ERN11.69253255
27PRPF4B1.64050049
28RPS6KB21.59120960
29TESK11.58765849
30MAP3K21.58054601
31SGK31.53925600
32MELK1.49150830
33LATS21.48885829
34TAOK21.48844962
35MAP3K11.45233757
36YES11.45139540
37CDK41.44971957
38MAP3K81.42769066
39TXK1.42288761
40SCYL21.42086250
41STK31.41638465
42RPS6KA41.41302388
43FGFR31.40353505
44PIK3CG1.38009777
45MAP3K111.37723448
46MAP3K141.37281480
47LRRK21.33291290
48HCK1.32569667
49MOS1.32432584
50NME21.31484336
51KSR21.29154540
52PLK41.26539642
53PLK21.26187391
54MAP2K31.18239451
55STK41.17137415
56CHEK21.16877736
57BMPR21.14024348
58DYRK31.13832133
59MARK21.13502925
60GRK61.11154447
61LYN1.11143402
62BRSK11.10902405
63ACVR1B1.09247450
64PLK11.08724370
65SGK2231.08608603
66SGK4941.08608603
67MAP3K61.08407409
68BRSK21.07779001
69JAK11.05784820
70FLT31.05048002
71PIM11.04720852
72IRAK11.02929676
73EPHB11.02718262
74CDK61.01593958
75TYK21.00777451
76MAP3K130.99893921
77PAK40.97854218
78MAP3K50.96950114
79ERBB20.96153451
80TGFBR20.93741172
81IRAK20.92955466
82MAP3K30.91257368
83CDK70.90512870
84NEK10.90273881
85MAPK110.90134320
86AURKB0.89899206
87LATS10.89586419
88ITK0.88891418
89RAF10.88254441
90TBK10.87853072
91KIT0.87753163
92TEC0.86004243
93CSF1R0.84397946
94DYRK1A0.82543017
95LCK0.81618176
96CDK90.81017057
97TAOK30.79009035
98FGFR40.78996062
99JAK30.76101517
100CAMKK20.74625482
101FRK0.73195003
102AURKA0.71825922
103ILK0.71007821
104CDK80.70748896
105CAMK1D0.69689639
106PIM20.68751004
107TRPM70.68161657
108CLK10.67437762
109STK110.66773042
110CHEK10.66565384
111MAP2K40.64983963
112PAK10.64689205
113STK380.64478171
114ZAP700.64156614
115SGK10.62808351
116TNK20.61705907
117MAP3K90.61676861
118HIPK20.60265929
119ATR0.60134829
120BTK0.59892538
121SYK0.57328160
122IKBKB0.57177345
123LIMK10.56817492
124DYRK1B0.54515660
125PDK10.54158359
126TLK10.53661228
127MATK0.51068926
128CAMK40.49803196
129EGFR0.48650799
130MAP2K20.48505912
131SMG10.48108355
132PTK60.48090865
133NEK90.47780805
134PLK30.47122246
135TGFBR10.46689361
136MAPKAPK20.46224672
137JAK20.45516333
138CDK20.45346201
139NLK0.45166327
140DYRK20.42822389
141ALK0.42248839
142STK38L0.41670516
143BLK0.41563608
144BRAF0.41454564
145BMX0.41212210
146KDR0.40923283
147CHUK0.40659164
148MAP3K70.40456782
149CSK0.40245168
150FYN0.40077647
151MTOR0.39476881
152RET0.39430943
153PRKAA20.38630694
154MARK30.38499040
155PDK30.35336547
156PDK40.35336547
157KSR10.35148005

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.36589010
2Cell cycle_Homo sapiens_hsa041102.99411729
3Mismatch repair_Homo sapiens_hsa034302.41724046
4RNA transport_Homo sapiens_hsa030132.28873475
5Base excision repair_Homo sapiens_hsa034102.26402408
6p53 signaling pathway_Homo sapiens_hsa041151.93413694
7Vitamin B6 metabolism_Homo sapiens_hsa007501.89817840
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69954880
9Pancreatic cancer_Homo sapiens_hsa052121.69682034
10Spliceosome_Homo sapiens_hsa030401.65783110
11B cell receptor signaling pathway_Homo sapiens_hsa046621.64226729
12Chronic myeloid leukemia_Homo sapiens_hsa052201.64139146
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.56508502
14Chemokine signaling pathway_Homo sapiens_hsa040621.52586081
15Leishmaniasis_Homo sapiens_hsa051401.48218360
16Homologous recombination_Homo sapiens_hsa034401.46901110
17Platelet activation_Homo sapiens_hsa046111.46072033
18Nucleotide excision repair_Homo sapiens_hsa034201.46053284
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44476445
20Herpes simplex infection_Homo sapiens_hsa051681.43792939
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41792243
22Staphylococcus aureus infection_Homo sapiens_hsa051501.41715980
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.38026532
24Basal transcription factors_Homo sapiens_hsa030221.37193890
25Epstein-Barr virus infection_Homo sapiens_hsa051691.36082086
26RNA degradation_Homo sapiens_hsa030181.35863854
27Colorectal cancer_Homo sapiens_hsa052101.34829276
28Viral carcinogenesis_Homo sapiens_hsa052031.31188911
29Small cell lung cancer_Homo sapiens_hsa052221.31165886
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30985329
31Antigen processing and presentation_Homo sapiens_hsa046121.30584976
32Inositol phosphate metabolism_Homo sapiens_hsa005621.29689443
33Shigellosis_Homo sapiens_hsa051311.28700804
34Systemic lupus erythematosus_Homo sapiens_hsa053221.27285440
35mRNA surveillance pathway_Homo sapiens_hsa030151.26770617
36Dorso-ventral axis formation_Homo sapiens_hsa043201.24736927
37Apoptosis_Homo sapiens_hsa042101.23512956
38RNA polymerase_Homo sapiens_hsa030201.21803676
39Hepatitis B_Homo sapiens_hsa051611.19276688
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.19024387
41Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.15688089
42Oocyte meiosis_Homo sapiens_hsa041141.15200907
43Pyrimidine metabolism_Homo sapiens_hsa002401.12297177
44Toxoplasmosis_Homo sapiens_hsa051451.10437427
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09847686
46Glioma_Homo sapiens_hsa052141.09719410
47MicroRNAs in cancer_Homo sapiens_hsa052061.08494391
48One carbon pool by folate_Homo sapiens_hsa006701.08424728
49Measles_Homo sapiens_hsa051621.07797057
50HTLV-I infection_Homo sapiens_hsa051661.07710069
51Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06891573
52Pentose phosphate pathway_Homo sapiens_hsa000301.06868789
53Primary immunodeficiency_Homo sapiens_hsa053401.06581795
54Osteoclast differentiation_Homo sapiens_hsa043801.06220914
55Fanconi anemia pathway_Homo sapiens_hsa034601.06139300
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02923487
57Bladder cancer_Homo sapiens_hsa052191.01861492
58Non-small cell lung cancer_Homo sapiens_hsa052231.01266684
59Acute myeloid leukemia_Homo sapiens_hsa052211.00799323
60Proteasome_Homo sapiens_hsa030501.00177279
61Influenza A_Homo sapiens_hsa051640.99346285
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.97659325
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96457671
64Legionellosis_Homo sapiens_hsa051340.95188858
65VEGF signaling pathway_Homo sapiens_hsa043700.94099308
66ErbB signaling pathway_Homo sapiens_hsa040120.93336671
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92696473
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.91776195
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90203116
70mTOR signaling pathway_Homo sapiens_hsa041500.87305181
71Graft-versus-host disease_Homo sapiens_hsa053320.87119549
72Choline metabolism in cancer_Homo sapiens_hsa052310.84278292
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83971768
74Adherens junction_Homo sapiens_hsa045200.83850385
75TGF-beta signaling pathway_Homo sapiens_hsa043500.83705564
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83611376
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83300147
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81217177
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80867828
80Phagosome_Homo sapiens_hsa041450.79662706
81Allograft rejection_Homo sapiens_hsa053300.79139016
82Hematopoietic cell lineage_Homo sapiens_hsa046400.78553553
83Endometrial cancer_Homo sapiens_hsa052130.78484342
84T cell receptor signaling pathway_Homo sapiens_hsa046600.77576202
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77325931
86Autoimmune thyroid disease_Homo sapiens_hsa053200.76764460
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.76604729
88Sulfur relay system_Homo sapiens_hsa041220.76451373
89Thyroid cancer_Homo sapiens_hsa052160.75921272
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.75340818
91African trypanosomiasis_Homo sapiens_hsa051430.75085646
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74885156
93Ribosome_Homo sapiens_hsa030100.72867124
94Renal cell carcinoma_Homo sapiens_hsa052110.72777712
95Prolactin signaling pathway_Homo sapiens_hsa049170.72734624
96Viral myocarditis_Homo sapiens_hsa054160.71683117
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70377378
98AMPK signaling pathway_Homo sapiens_hsa041520.70297485
99FoxO signaling pathway_Homo sapiens_hsa040680.70250861
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69714892
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68715493
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.68480899
103Malaria_Homo sapiens_hsa051440.68232915
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.68092142
105TNF signaling pathway_Homo sapiens_hsa046680.67196329
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.66409717
107GnRH signaling pathway_Homo sapiens_hsa049120.66142726
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.65226070
109Regulation of autophagy_Homo sapiens_hsa041400.64996159
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64656954
111Hippo signaling pathway_Homo sapiens_hsa043900.62304132
112Tuberculosis_Homo sapiens_hsa051520.62023528
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61789905
114Insulin resistance_Homo sapiens_hsa049310.61107218
115Long-term potentiation_Homo sapiens_hsa047200.60772534
116Prostate cancer_Homo sapiens_hsa052150.59974461
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59428740
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58549006
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58104732
120Type II diabetes mellitus_Homo sapiens_hsa049300.57787913
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.57186492
122Non-homologous end-joining_Homo sapiens_hsa034500.56892067
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55476957
124HIF-1 signaling pathway_Homo sapiens_hsa040660.54778589
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54060337
126Notch signaling pathway_Homo sapiens_hsa043300.53073036
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52965292
128Hepatitis C_Homo sapiens_hsa051600.50262669
129Biosynthesis of amino acids_Homo sapiens_hsa012300.49997307
130Salmonella infection_Homo sapiens_hsa051320.49061541
131MAPK signaling pathway_Homo sapiens_hsa040100.48060019
132Endocytosis_Homo sapiens_hsa041440.47754450
133Insulin signaling pathway_Homo sapiens_hsa049100.47663231
134Proteoglycans in cancer_Homo sapiens_hsa052050.46898292
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46449032
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46231518
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.45740588
138Pathways in cancer_Homo sapiens_hsa052000.45522780
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45318059
140Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42913213

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