DCAF10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mitochondrial calcium ion concentration (GO:0051561)7.74863358
2mitochondrial calcium ion transport (GO:0006851)7.38065327
3response to pheromone (GO:0019236)6.53054489
4vitamin transmembrane transport (GO:0035461)5.01364408
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.80848409
6L-phenylalanine catabolic process (GO:0006559)4.80848409
7mitochondrial calcium ion homeostasis (GO:0051560)4.61444477
8peptidyl-glutamic acid carboxylation (GO:0017187)4.55281355
9protein carboxylation (GO:0018214)4.55281355
10aromatic amino acid family catabolic process (GO:0009074)4.46122656
11behavioral response to nicotine (GO:0035095)4.44102224
12homocysteine metabolic process (GO:0050667)4.38659326
13magnesium ion transport (GO:0015693)4.38373785
14regulation of fibrinolysis (GO:0051917)4.36183747
15protein K11-linked deubiquitination (GO:0035871)4.35353417
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.29292813
17L-phenylalanine metabolic process (GO:0006558)4.29292813
18cysteine metabolic process (GO:0006534)4.26659758
19tryptophan catabolic process (GO:0006569)4.09196890
20indole-containing compound catabolic process (GO:0042436)4.09196890
21indolalkylamine catabolic process (GO:0046218)4.09196890
22tryptophan metabolic process (GO:0006568)4.08693291
23serine family amino acid catabolic process (GO:0009071)4.03578346
24protein prenylation (GO:0018342)3.99901212
25prenylation (GO:0097354)3.99901212
26cellular glucuronidation (GO:0052695)3.99721194
27cellular protein complex localization (GO:0034629)3.98744444
28urea metabolic process (GO:0019627)3.91573647
29urea cycle (GO:0000050)3.91573647
30microtubule anchoring (GO:0034453)3.90986922
31positive regulation of fatty acid beta-oxidation (GO:0032000)3.88574212
32complement activation, alternative pathway (GO:0006957)3.82728103
33amino-acid betaine metabolic process (GO:0006577)3.82685106
34triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.82594353
35negative regulation of fibrinolysis (GO:0051918)3.77857536
36intestinal cholesterol absorption (GO:0030299)3.75817093
37regulation of protein activation cascade (GO:2000257)3.74369592
38bile acid biosynthetic process (GO:0006699)3.67388223
39very-low-density lipoprotein particle assembly (GO:0034379)3.63842123
40acylglycerol homeostasis (GO:0055090)3.62834233
41triglyceride homeostasis (GO:0070328)3.62834233
42oxidative demethylation (GO:0070989)3.61179297
43uronic acid metabolic process (GO:0006063)3.59833237
44glucuronate metabolic process (GO:0019585)3.59833237
45bile acid metabolic process (GO:0008206)3.57312268
46NADH dehydrogenase complex assembly (GO:0010257)3.57295859
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57295859
48mitochondrial respiratory chain complex I assembly (GO:0032981)3.57295859
49alpha-linolenic acid metabolic process (GO:0036109)3.57107613
50establishment of protein localization to Golgi (GO:0072600)3.52047708
51kynurenine metabolic process (GO:0070189)3.49730994
52high-density lipoprotein particle remodeling (GO:0034375)3.48881562
53cholesterol efflux (GO:0033344)3.48824314
54nitrogen cycle metabolic process (GO:0071941)3.48136969
55regulation of complement activation (GO:0030449)3.47741645
56tyrosine metabolic process (GO:0006570)3.46820748
57fibrinolysis (GO:0042730)3.39185285
58kidney morphogenesis (GO:0060993)3.37110297
59reverse cholesterol transport (GO:0043691)3.31989077
60water-soluble vitamin biosynthetic process (GO:0042364)3.31386673
61COPII vesicle coating (GO:0048208)3.30755524
62signal peptide processing (GO:0006465)3.30012730
63positive regulation of lipid catabolic process (GO:0050996)3.28598346
64protein targeting to Golgi (GO:0000042)3.25611229
65negative regulation of lipase activity (GO:0060192)3.25490121
66fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.24847867
67phospholipid homeostasis (GO:0055091)3.23909068
68protein localization to Golgi apparatus (GO:0034067)3.22006767
69plasma lipoprotein particle assembly (GO:0034377)3.21048113
70replicative senescence (GO:0090399)3.18982632
71aromatic amino acid family metabolic process (GO:0009072)3.18533606
72drug catabolic process (GO:0042737)3.16356854
73endocrine pancreas development (GO:0031018)3.15807896
74positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.15003197
75monoubiquitinated protein deubiquitination (GO:0035520)3.12524659
76protein-lipid complex remodeling (GO:0034368)3.12265379
77macromolecular complex remodeling (GO:0034367)3.12265379
78plasma lipoprotein particle remodeling (GO:0034369)3.12265379
79coenzyme catabolic process (GO:0009109)3.12174640
804-hydroxyproline metabolic process (GO:0019471)3.11256637
81pyrimidine-containing compound transmembrane transport (GO:0072531)3.11132583
82regulation of triglyceride catabolic process (GO:0010896)3.09369632
83bile acid and bile salt transport (GO:0015721)3.09145282
84glyoxylate metabolic process (GO:0046487)3.08209632
85linoleic acid metabolic process (GO:0043651)3.08071429
86retrograde transport, vesicle recycling within Golgi (GO:0000301)3.07778381
87indolalkylamine metabolic process (GO:0006586)3.05718388
88neural tube formation (GO:0001841)3.01426730
89phospholipid efflux (GO:0033700)2.98388936
90plasma lipoprotein particle clearance (GO:0034381)2.95776886
91iron ion import (GO:0097286)2.95092943
92azole transport (GO:0045117)2.94359135
93nonmotile primary cilium assembly (GO:0035058)2.92980088
94embryonic retina morphogenesis in camera-type eye (GO:0060059)2.91899735
95fucose catabolic process (GO:0019317)2.91299951
96L-fucose metabolic process (GO:0042354)2.91299951
97L-fucose catabolic process (GO:0042355)2.91299951
98interkinetic nuclear migration (GO:0022027)2.90237118
99chondrocyte development (GO:0002063)2.88023594
100protein-lipid complex assembly (GO:0065005)2.87954407
101platelet dense granule organization (GO:0060155)2.87500361
102lipoprotein metabolic process (GO:0042157)2.86638523
103plasma lipoprotein particle organization (GO:0071827)2.86467259
104UDP-N-acetylglucosamine metabolic process (GO:0006047)2.85461242
105sulfur amino acid catabolic process (GO:0000098)2.84649246
106alpha-amino acid catabolic process (GO:1901606)2.84539421
107blood coagulation, intrinsic pathway (GO:0007597)2.82492123
108protein complex biogenesis (GO:0070271)2.79538476
109ketone body metabolic process (GO:1902224)2.79089332
110cartilage morphogenesis (GO:0060536)2.78991505
111regulation of bile acid biosynthetic process (GO:0070857)2.78599096
112definitive hemopoiesis (GO:0060216)2.78185960
113regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.78085756
114negative regulation of hemostasis (GO:1900047)2.78066306
115negative regulation of blood coagulation (GO:0030195)2.78066306
116regulation of plasminogen activation (GO:0010755)2.78030104
117S-adenosylmethionine metabolic process (GO:0046500)2.76785633
118intestinal absorption (GO:0050892)2.76486883
119amine catabolic process (GO:0009310)2.76047396
120cellular biogenic amine catabolic process (GO:0042402)2.76047396
121regulation of hippo signaling (GO:0035330)2.75409950
122centriole replication (GO:0007099)2.75153443
123short-chain fatty acid metabolic process (GO:0046459)2.74949307
124lateral ventricle development (GO:0021670)2.73393903
125sterol homeostasis (GO:0055092)2.73048772
126cholesterol homeostasis (GO:0042632)2.72302761
127negative regulation of wound healing (GO:0061045)2.72124608
128acute-phase response (GO:0006953)2.71690325
129prostate gland growth (GO:0060736)2.69636647
130protein-lipid complex subunit organization (GO:0071825)2.69482582
131regulation of fatty acid beta-oxidation (GO:0031998)2.69022024
132alkaloid metabolic process (GO:0009820)2.68228001
133positive regulation of glycolytic process (GO:0045821)2.65741364
134positive regulation of fatty acid oxidation (GO:0046321)2.64245971
135regulation of DNA endoreduplication (GO:0032875)2.63819816
136cofactor catabolic process (GO:0051187)2.63605821
137cholesterol transport (GO:0030301)2.62659014
138sterol transport (GO:0015918)2.62659014
139branched-chain amino acid catabolic process (GO:0009083)2.61861892
140detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.61568566
141regulation of extracellular matrix disassembly (GO:0010715)2.61326461
142detection of light stimulus involved in sensory perception (GO:0050962)2.60822736
143detection of light stimulus involved in visual perception (GO:0050908)2.60822736
144cellular ketone body metabolic process (GO:0046950)2.60062611
145regulation of translation, ncRNA-mediated (GO:0045974)2.59225097
146negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.59225097
147negative regulation of translation, ncRNA-mediated (GO:0040033)2.59225097
148nicotinamide nucleotide biosynthetic process (GO:0019359)2.55432227
149cornea development in camera-type eye (GO:0061303)2.53861711
150preassembly of GPI anchor in ER membrane (GO:0016254)2.51659029
151gene silencing by RNA (GO:0031047)2.50305342
152purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.48489271
1533-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.48489271
154head development (GO:0060322)2.44355559
155positive regulation of meiosis (GO:0045836)2.43225174
156mitochondrial respiratory chain complex assembly (GO:0033108)2.42374204
157positive regulation of cardiac muscle cell differentiation (GO:2000727)2.41412391
158photoreceptor cell maintenance (GO:0045494)2.41402584
159artery development (GO:0060840)2.38742296
160negative regulation of cytosolic calcium ion concentration (GO:0051481)2.36950957
161inositol metabolic process (GO:0006020)2.36730935
162regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.35983511
163nucleotide transmembrane transport (GO:1901679)2.35810385
164regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.35299232
165mannosylation (GO:0097502)2.35289666
166lung epithelial cell differentiation (GO:0060487)2.34668502
167multicellular organism reproduction (GO:0032504)2.33915576
168limb development (GO:0060173)2.32760218
169appendage development (GO:0048736)2.32760218
170negative regulation of activin receptor signaling pathway (GO:0032926)2.32311166
171regulation of acyl-CoA biosynthetic process (GO:0050812)2.31613107
172embryonic epithelial tube formation (GO:0001838)2.31474241
173negative regulation of smooth muscle cell differentiation (GO:0051151)2.30997556
174negative regulation of JUN kinase activity (GO:0043508)2.29458473
175alternative mRNA splicing, via spliceosome (GO:0000380)2.28149105
176reflex (GO:0060004)2.28113995
177intestinal epithelial cell development (GO:0060576)2.27994794
178attachment of spindle microtubules to kinetochore (GO:0008608)2.27742845
179peptidyl-threonine dephosphorylation (GO:0035970)2.27265480
180hematopoietic stem cell proliferation (GO:0071425)2.24408276
181positive regulation of meiotic cell cycle (GO:0051446)2.23619913
182cellular response to ATP (GO:0071318)2.23565307
183snRNA transcription (GO:0009301)2.23023042
184negative regulation of heart growth (GO:0061117)2.20259666
185negative regulation of cardiac muscle tissue growth (GO:0055022)2.20259666
186negative regulation of keratinocyte proliferation (GO:0010839)2.19996240
187lung cell differentiation (GO:0060479)2.19422876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.65726717
2EGR1_23403033_ChIP-Seq_LIVER_Mouse3.61991369
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.60916764
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.58200984
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.48782875
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.44891493
7GATA1_22025678_ChIP-Seq_K562_Human3.18947267
8IGF1R_20145208_ChIP-Seq_DFB_Human2.99438930
9* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.90550296
10FUS_26573619_Chip-Seq_HEK293_Human2.79450411
11* EWS_26573619_Chip-Seq_HEK293_Human2.55595028
12VDR_22108803_ChIP-Seq_LS180_Human2.30916987
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.27111125
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.25328024
15ZNF274_21170338_ChIP-Seq_K562_Hela2.25295171
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.24239789
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14119049
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.99654956
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98774396
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95930173
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.93916768
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.91970028
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.89420697
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.86478825
25CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.75219945
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.73385862
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.69593022
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67866920
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.67303631
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.63940736
31FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61833215
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.58375231
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56170784
34* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.55106447
35CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.54892279
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.54844108
37* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51793675
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.50050175
39NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49885960
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49885960
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49771674
42CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.48990574
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46827125
44CBP_20019798_ChIP-Seq_JUKART_Human1.46827125
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.45229099
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44251770
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43927800
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43512067
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.43008137
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.42833627
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40768291
52FOXM1_26456572_ChIP-Seq_MCF-7_Human1.40649299
53BCAT_22108803_ChIP-Seq_LS180_Human1.39578921
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.38759813
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35642795
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.34929648
57EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32318581
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31042439
59RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31015482
60OCT4_21477851_ChIP-Seq_ESCs_Mouse1.30248886
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30147791
62GBX2_23144817_ChIP-Seq_PC3_Human1.30054672
63AR_21572438_ChIP-Seq_LNCaP_Human1.29058527
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.28631166
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28294514
66TP53_18474530_ChIP-ChIP_U2OS_Human1.26783174
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26333211
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25889412
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24733043
70TBL1_22424771_ChIP-Seq_293T_Human1.23763204
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.23711168
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.23693764
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23343729
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.23288960
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.22387750
76CJUN_26792858_Chip-Seq_BT549_Human1.22353133
77TP53_22573176_ChIP-Seq_HFKS_Human1.21474518
78P53_22387025_ChIP-Seq_ESCs_Mouse1.20168022
79NFYB_21822215_ChIP-Seq_K562_Human1.19744744
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.19024133
81SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18670992
82TAF15_26573619_Chip-Seq_HEK293_Human1.18290374
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18067526
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16586537
85FOXA1_25552417_ChIP-Seq_VCAP_Human1.15985058
86FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14686373
87PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13256936
88P300_19829295_ChIP-Seq_ESCs_Human1.12714280
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.12436008
90FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12350090
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11308571
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10613047
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10570016
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09446273
95GF1B_26923725_Chip-Seq_HPCs_Mouse1.09312472
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09095858
97NANOG_19829295_ChIP-Seq_ESCs_Human1.08951170
98SOX2_19829295_ChIP-Seq_ESCs_Human1.08951170
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08726222
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08717100
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08715724
102AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07262368
103OCT4_18555785_Chip-Seq_ESCs_Mouse1.06955638
104WT1_19549856_ChIP-ChIP_CCG9911_Human1.06645539
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05960799
106STAT3_18555785_Chip-Seq_ESCs_Mouse1.05881190
107TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04951600
108STAT3_23295773_ChIP-Seq_U87_Human1.04932349
109P300_18555785_Chip-Seq_ESCs_Mouse1.04711834
110ESRRB_18555785_Chip-Seq_ESCs_Mouse1.04710865
111NMYC_18555785_Chip-Seq_ESCs_Mouse1.04070408
112CBX2_22325352_ChIP-Seq_293T-Rex_Human1.03956706
113ELK1_19687146_ChIP-ChIP_HELA_Human1.03876158
114SMAD4_21799915_ChIP-Seq_A2780_Human1.03705931
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.03622179
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03449522
117FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.03242100
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02773713
119EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02565987
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02546791
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02546791
122GATA4_25053715_ChIP-Seq_YYC3_Human1.02345985
123SOX2_18555785_Chip-Seq_ESCs_Mouse1.02152653
124TCF4_23295773_ChIP-Seq_U87_Human1.02088763
125GATA2_21666600_ChIP-Seq_HMVEC_Human0.99732706
126RUNX2_22187159_ChIP-Seq_PCA_Human0.99400393
127PU1_27457419_Chip-Seq_LIVER_Mouse0.99260965
128TP53_16413492_ChIP-PET_HCT116_Human0.98999921
129TCF4_22108803_ChIP-Seq_LS180_Human0.98521783
130* CDX2_22108803_ChIP-Seq_LS180_Human0.98356160
131ER_23166858_ChIP-Seq_MCF-7_Human0.97784246
132ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97197597
133CMYC_18555785_Chip-Seq_ESCs_Mouse0.96119072
134AHR_22903824_ChIP-Seq_MCF-7_Human0.96070980
135AR_25329375_ChIP-Seq_VCAP_Human0.95701250
136* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95337498
137RUNX1_27457419_Chip-Seq_LIVER_Mouse0.94784399
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94659998

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.21793927
2MP0005085_abnormal_gallbladder_physiolo4.94492762
3MP0005365_abnormal_bile_salt4.92731606
4MP0005360_urolithiasis4.63340452
5MP0003252_abnormal_bile_duct3.25969901
6MP0002653_abnormal_ependyma_morphology3.01266574
7MP0005083_abnormal_biliary_tract2.89280110
8MP0008875_abnormal_xenobiotic_pharmacok2.59515386
9MP0002938_white_spotting2.56677684
10MP0005174_abnormal_tail_pigmentation2.51221042
11MP0001666_abnormal_nutrient_absorption2.43873966
12MP0008057_abnormal_DNA_replication2.43373661
13MP0002138_abnormal_hepatobiliary_system2.41802502
14MP0003868_abnormal_feces_composition2.39191879
15MP0002837_dystrophic_cardiac_calcinosis2.31275299
16MP0010329_abnormal_lipoprotein_level2.28364118
17MP0005670_abnormal_white_adipose2.02079616
18MP0006072_abnormal_retinal_apoptosis1.93970843
19MP0000631_abnormal_neuroendocrine_gland1.83030459
20MP0004185_abnormal_adipocyte_glucose1.82893786
21MP0005408_hypopigmentation1.82228234
22MP0005220_abnormal_exocrine_pancreas1.80479385
23MP0000609_abnormal_liver_physiology1.74743257
24MP0002166_altered_tumor_susceptibility1.73135455
25MP0004272_abnormal_basement_membrane1.68349262
26MP0005248_abnormal_Harderian_gland1.67898101
27MP0005551_abnormal_eye_electrophysiolog1.67359831
28MP0003937_abnormal_limbs/digits/tail_de1.66334986
29MP0003646_muscle_fatigue1.65031818
30MP0003195_calcinosis1.63437489
31MP0002234_abnormal_pharynx_morphology1.62588093
32MP0003787_abnormal_imprinting1.60849431
33MP0005084_abnormal_gallbladder_morpholo1.60662319
34MP0002160_abnormal_reproductive_system1.59301209
35MP0002877_abnormal_melanocyte_morpholog1.58977702
36MP0005253_abnormal_eye_physiology1.57981330
37MP0002928_abnormal_bile_duct1.57480405
38MP0010368_abnormal_lymphatic_system1.55267828
39MP0002118_abnormal_lipid_homeostasis1.55235440
40MP0009384_cardiac_valve_regurgitation1.54988580
41MP0002006_tumorigenesis1.54666297
42MP0004885_abnormal_endolymph1.52747330
43MP0005332_abnormal_amino_acid1.52568848
44MP0002095_abnormal_skin_pigmentation1.52068331
45MP0001661_extended_life_span1.51811699
46MP0004130_abnormal_muscle_cell1.51472837
47MP0009780_abnormal_chondrocyte_physiolo1.49544508
48MP0005503_abnormal_tendon_morphology1.49364038
49MP0003300_gastrointestinal_ulcer1.44783081
50MP0005076_abnormal_cell_differentiation1.44473380
51MP0001944_abnormal_pancreas_morphology1.44172625
52MP0006292_abnormal_olfactory_placode1.42211143
53MP0005409_darkened_coat_color1.41490835
54MP0003890_abnormal_embryonic-extraembry1.40164825
55MP0005646_abnormal_pituitary_gland1.40017383
56MP0009697_abnormal_copulation1.36265276
57MP0005379_endocrine/exocrine_gland_phen1.35137246
58MP0003942_abnormal_urinary_system1.33193423
59MP0000427_abnormal_hair_cycle1.32715265
60MP0003283_abnormal_digestive_organ1.31484520
61MP0002102_abnormal_ear_morphology1.27612523
62MP0001346_abnormal_lacrimal_gland1.25085943
63MP0005666_abnormal_adipose_tissue1.24788612
64MP0002177_abnormal_outer_ear1.22649337
65MP0002060_abnormal_skin_morphology1.20295042
66MP0000566_synostosis1.19749668
67MP0002909_abnormal_adrenal_gland1.19134732
68MP0008961_abnormal_basal_metabolism1.15647268
69MP0002896_abnormal_bone_mineralization1.14961152
70MP0009053_abnormal_anal_canal1.14261958
71MP0003724_increased_susceptibility_to1.14228215
72MP0009764_decreased_sensitivity_to1.14198253
73MP0008877_abnormal_DNA_methylation1.13382886
74MP0002638_abnormal_pupillary_reflex1.13212956
75MP0004019_abnormal_vitamin_homeostasis1.12397288
76MP0005451_abnormal_body_composition1.12095763
77MP0009379_abnormal_foot_pigmentation1.09766956
78MP0000647_abnormal_sebaceous_gland1.09461035
79MP0002971_abnormal_brown_adipose1.09460588
80MP0008775_abnormal_heart_ventricle1.09355337
81MP0003705_abnormal_hypodermis_morpholog1.08815324
82MP0005389_reproductive_system_phenotype1.08664147
83MP0005334_abnormal_fat_pad1.06382383
84MP0002693_abnormal_pancreas_physiology1.05766881
85MP0005647_abnormal_sex_gland1.05408169
86MP0000013_abnormal_adipose_tissue1.05015460
87MP0000613_abnormal_salivary_gland1.04459815
88MP0001764_abnormal_homeostasis1.04186652
89MP0000383_abnormal_hair_follicle1.03755485
90MP0003755_abnormal_palate_morphology1.03592421
91MP0005187_abnormal_penis_morphology1.03529424
92MP0001293_anophthalmia1.03266238
93MP0004133_heterotaxia1.02391880
94MP0000516_abnormal_urinary_system1.01420202
95MP0005367_renal/urinary_system_phenotyp1.01420202
96MP0002078_abnormal_glucose_homeostasis1.01296164
97MP0004142_abnormal_muscle_tone0.98830865
98MP0004381_abnormal_hair_follicle0.97098343
99MP0002876_abnormal_thyroid_physiology0.96962508
100MP0002009_preneoplasia0.94533107
101MP0001188_hyperpigmentation0.94193044
102MP0008438_abnormal_cutaneous_collagen0.94123606
103MP0003121_genomic_imprinting0.92191807
104MP0003936_abnormal_reproductive_system0.91947963
105MP0010352_gastrointestinal_tract_polyps0.90760429
106MP0005645_abnormal_hypothalamus_physiol0.90718154
107MP0005535_abnormal_body_temperature0.90198548
108MP0002254_reproductive_system_inflammat0.86774926
109MP0005448_abnormal_energy_balance0.86007751
110MP0002132_abnormal_respiratory_system0.85866196
111MP0009250_abnormal_appendicular_skeleto0.85480163
112MP0001879_abnormal_lymphatic_vessel0.85044554
113MP0003935_abnormal_craniofacial_develop0.84373477
114MP0010678_abnormal_skin_adnexa0.84109905
115MP0002933_joint_inflammation0.83319535
116MP0004145_abnormal_muscle_electrophysio0.83195870
117MP0000598_abnormal_liver_morphology0.82728677
118MP0002751_abnormal_autonomic_nervous0.81239006
119MP0010386_abnormal_urinary_bladder0.80821424
120MP0005391_vision/eye_phenotype0.80436520
121MP0005195_abnormal_posterior_eye0.80203643
122MP0004085_abnormal_heartbeat0.80150081
123MP0004924_abnormal_behavior0.79566438
124MP0005386_behavior/neurological_phenoty0.79566438
125MP0001324_abnormal_eye_pigmentation0.79086403
126MP0005410_abnormal_fertilization0.79047734
127MP0009046_muscle_twitch0.78801211
128MP0000639_abnormal_adrenal_gland0.78354911
129MP0003011_delayed_dark_adaptation0.78307186
130MP0009115_abnormal_fat_cell0.77159131
131MP0006276_abnormal_autonomic_nervous0.76507918
132MP0000163_abnormal_cartilage_morphology0.76370596
133MP0004782_abnormal_surfactant_physiolog0.74397603
134MP0000462_abnormal_digestive_system0.73882765
135MP0001919_abnormal_reproductive_system0.73207181
136MP0002098_abnormal_vibrissa_morphology0.71437447
137MP0009763_increased_sensitivity_to0.71224697
138MP0002109_abnormal_limb_morphology0.69888535
139MP0000569_abnormal_digit_pigmentation0.69516806
140MP0005375_adipose_tissue_phenotype0.68831043
141MP0005319_abnormal_enzyme/_coenzyme0.67946994
142MP0002295_abnormal_pulmonary_circulatio0.67821296
143MP0004134_abnormal_chest_morphology0.67549551
144MP0004947_skin_inflammation0.66764700
145MP0005164_abnormal_response_to0.65904873
146MP0009643_abnormal_urine_homeostasis0.64360108
147MP0000015_abnormal_ear_pigmentation0.63917148
148MP0009672_abnormal_birth_weight0.62624730
149MP0002115_abnormal_skeleton_extremities0.60995717
150MP0002282_abnormal_trachea_morphology0.60838144
151MP0004043_abnormal_pH_regulation0.59803152
152MP0001216_abnormal_epidermal_layer0.59031329
153MP0001915_intracranial_hemorrhage0.58782876
154MP0000762_abnormal_tongue_morphology0.58557725
155MP0002249_abnormal_larynx_morphology0.58526245
156MP0000627_abnormal_mammary_gland0.58066906
157MP0009642_abnormal_blood_homeostasis0.57879775
158MP0000538_abnormal_urinary_bladder0.57154932
159MP0000377_abnormal_hair_follicle0.56995819
160MP0001299_abnormal_eye_distance/0.56971713
161MP0003656_abnormal_erythrocyte_physiolo0.56954221
162MP0002697_abnormal_eye_size0.56780392

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.21646821
2Prolonged partial thromboplastin time (HP:0003645)4.86881153
3Pancreatic cysts (HP:0001737)4.76940203
4Deep venous thrombosis (HP:0002625)4.25495608
5Abnormality of the common coagulation pathway (HP:0010990)4.14612413
6Pheochromocytoma (HP:0002666)3.96147598
7Hypoglycemic coma (HP:0001325)3.84417213
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.73945828
9Xanthomatosis (HP:0000991)3.70031249
10Joint hemorrhage (HP:0005261)3.69382538
11Absent rod-and cone-mediated responses on ERG (HP:0007688)3.61798723
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.61501280
13Neuroendocrine neoplasm (HP:0100634)3.52680176
14Pancreatic fibrosis (HP:0100732)3.48994761
15Hypoglycemic seizures (HP:0002173)3.47042826
16Abnormal rod and cone electroretinograms (HP:0008323)3.43400004
17Epidermoid cyst (HP:0200040)3.41140401
18Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.40793560
19Abnormality of alanine metabolism (HP:0010916)3.40793560
20Hyperalaninemia (HP:0003348)3.40793560
21Abnormality of the intrinsic pathway (HP:0010989)3.34703956
22Nephronophthisis (HP:0000090)3.31655524
23Hyperinsulinemic hypoglycemia (HP:0000825)3.28725119
24Abnormal tarsal ossification (HP:0008369)3.27654124
25Conjugated hyperbilirubinemia (HP:0002908)3.26834820
26Hyperglycemia (HP:0003074)3.24318025
27Myocardial infarction (HP:0001658)3.20584658
28Keratoconus (HP:0000563)3.19757249
29Increased corneal curvature (HP:0100692)3.19757249
30Hypoalphalipoproteinemia (HP:0003233)3.18577684
31Hyperglycinemia (HP:0002154)3.16694567
32Complement deficiency (HP:0004431)3.11915740
33Hypobetalipoproteinemia (HP:0003563)3.10038783
34Confusion (HP:0001289)3.09215890
35Abnormality of the renal medulla (HP:0100957)3.08637820
36True hermaphroditism (HP:0010459)3.06595209
37Fat malabsorption (HP:0002630)3.05296183
38Submucous cleft hard palate (HP:0000176)3.05181093
39Hypolipoproteinemia (HP:0010981)2.94009787
40Hyperlipoproteinemia (HP:0010980)2.93424678
41Acanthocytosis (HP:0001927)2.92871482
42Upper limb muscle weakness (HP:0003484)2.91222933
43Symptomatic seizures (HP:0011145)2.90948026
44Attenuation of retinal blood vessels (HP:0007843)2.87392754
45Inability to walk (HP:0002540)2.86257422
46Type II lissencephaly (HP:0007260)2.83930691
47Abnormality of glutamine family amino acid metabolism (HP:0010902)2.83830299
48Epiphyseal dysplasia (HP:0002656)2.83551371
49Macroorchidism (HP:0000053)2.83540779
50Insulin-resistant diabetes mellitus (HP:0000831)2.83117026
51Vitreoretinal degeneration (HP:0000655)2.80075762
52Tubular atrophy (HP:0000092)2.79370312
53Molar tooth sign on MRI (HP:0002419)2.74271206
54Abnormality of midbrain morphology (HP:0002418)2.74271206
55Pendular nystagmus (HP:0012043)2.73243495
56Hyperglycinuria (HP:0003108)2.72516289
57Chorioretinal atrophy (HP:0000533)2.72333121
58Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.70246380
59Abnormal foot bone ossification (HP:0010675)2.65469942
60Hepatocellular carcinoma (HP:0001402)2.64635603
61Congenital stationary night blindness (HP:0007642)2.64596016
62Renal cortical cysts (HP:0000803)2.64390193
63Medial flaring of the eyebrow (HP:0010747)2.61436959
64Hypoplastic ischia (HP:0003175)2.56505413
65Cupped ribs (HP:0000887)2.54470876
66Abnormality of serine family amino acid metabolism (HP:0010894)2.51558973
67Abnormality of glycine metabolism (HP:0010895)2.51558973
68Abnormality of the ischium (HP:0003174)2.49453708
69Furrowed tongue (HP:0000221)2.46871265
70Hypochromic microcytic anemia (HP:0004840)2.46763781
71Poor coordination (HP:0002370)2.45357726
72Abnormality of sulfur amino acid metabolism (HP:0004339)2.44253810
73Concave nail (HP:0001598)2.41050954
74Abnormality of the nasal septum (HP:0000419)2.39138493
75Decreased central vision (HP:0007663)2.38793248
76Gaze-evoked nystagmus (HP:0000640)2.33472535
77Ketosis (HP:0001946)2.31537256
78Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.29800719
79Genital tract atresia (HP:0001827)2.27718508
80Ketoacidosis (HP:0001993)2.25790773
81Morphological abnormality of the pyramidal tract (HP:0002062)2.25526284
82Poikilocytosis (HP:0004447)2.25313911
83Abolished electroretinogram (ERG) (HP:0000550)2.22368228
84Thyroid carcinoma (HP:0002890)2.20884682
85Abnormality of complement system (HP:0005339)2.20640332
86Hydroxyprolinuria (HP:0003080)2.17190331
87Abnormality of proline metabolism (HP:0010907)2.17190331
88Cystic hygroma (HP:0000476)2.16410601
89Enlarged kidneys (HP:0000105)2.15968111
90Congenital primary aphakia (HP:0007707)2.15451301
91Chronic hepatic failure (HP:0100626)2.15441908
92Abnormality of aspartate family amino acid metabolism (HP:0010899)2.15259810
93Abnormality of methionine metabolism (HP:0010901)2.14892013
94Curly hair (HP:0002212)2.14542280
95Gait imbalance (HP:0002141)2.14401747
96Vaginal atresia (HP:0000148)2.13732806
97Hypercholesterolemia (HP:0003124)2.13306875
98Steatorrhea (HP:0002570)2.10390343
99Fair hair (HP:0002286)2.09714862
100Hyperventilation (HP:0002883)2.08640049
101Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.07638929
102Aplasia/Hypoplasia of the tongue (HP:0010295)2.06651904
103Abnormality of homocysteine metabolism (HP:0010919)2.06330895
104Homocystinuria (HP:0002156)2.06330895
105Cerebellar dysplasia (HP:0007033)2.05725814
106Congenital, generalized hypertrichosis (HP:0004540)2.05719535
107Pancreatic islet-cell hyperplasia (HP:0004510)2.05183162
108Congenital sensorineural hearing impairment (HP:0008527)2.05110604
109Small epiphyses (HP:0010585)2.03268587
110Conjunctival hamartoma (HP:0100780)2.02899221
111Menorrhagia (HP:0000132)2.01543269
112Abnormality of the pancreatic islet cells (HP:0006476)2.00195066
113Abnormality of endocrine pancreas physiology (HP:0012093)2.00195066
114Pigmentary retinal degeneration (HP:0001146)1.99727041
115Cystic liver disease (HP:0006706)1.99623134
116Benign neoplasm of the central nervous system (HP:0100835)1.98916325
117Postaxial foot polydactyly (HP:0001830)1.97971204
118Premature rupture of membranes (HP:0001788)1.97380069
119Abnormality of purine metabolism (HP:0004352)1.97158357
120Sensory axonal neuropathy (HP:0003390)1.97029046
121Asymmetry of the thorax (HP:0001555)1.96846042
122Neoplasm of the tracheobronchial system (HP:0100552)1.96701986
123Mutism (HP:0002300)1.95277666
124Oligodactyly (hands) (HP:0001180)1.94954142
125Meningioma (HP:0002858)1.94612309
126Protuberant abdomen (HP:0001538)1.93878193
127Hamartoma of the eye (HP:0010568)1.92867623
128Abnormality of the phalanges of the 5th finger (HP:0004213)1.92310586
129Alveolar cell carcinoma (HP:0006519)1.91822014
130Capillary hemangiomas (HP:0005306)1.90183843
131Toxemia of pregnancy (HP:0100603)1.90119700
132Tinnitus (HP:0000360)1.89936974
133Abnormality of the proximal phalanges of the hand (HP:0009834)1.88857174
134Hamartoma (HP:0010566)1.88580890
135Nephrogenic diabetes insipidus (HP:0009806)1.87790110
136Arthropathy (HP:0003040)1.87003668
137Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86494154
138Abnormality of serum amino acid levels (HP:0003112)1.86053181
139Heterotopia (HP:0002282)1.85784240
140Abnormality of the renal cortex (HP:0011035)1.84498726
141Metaphyseal dysplasia (HP:0100255)1.84469248
142Postaxial hand polydactyly (HP:0001162)1.82869179
143Disproportionate short-trunk short stature (HP:0003521)1.81871511
144Esophageal varix (HP:0002040)1.81460839
145Cutaneous melanoma (HP:0012056)1.80585573
146Tetraparesis (HP:0002273)1.80137081
147Abnormality of nucleobase metabolism (HP:0010932)1.80039514
148Abnormality of the 4th metacarpal (HP:0010012)1.80016081
149Genetic anticipation (HP:0003743)1.79320343
150Partial agenesis of the corpus callosum (HP:0001338)1.78152437
151Short 4th metacarpal (HP:0010044)1.76779888
152Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.76779888
153Renovascular hypertension (HP:0100817)1.76556347
154Gingival bleeding (HP:0000225)1.75461671
155Generalized hypopigmentation of hair (HP:0011358)1.75253306
156Occipital encephalocele (HP:0002085)1.73554799
157Pancreatitis (HP:0001733)1.72844720
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.72707222
159Cerebral hemorrhage (HP:0001342)1.72604880
160Thyroid-stimulating hormone excess (HP:0002925)1.72550588
161Hemorrhage of the eye (HP:0011885)1.72171434
162Gonadotropin excess (HP:0000837)1.72099290
163Volvulus (HP:0002580)1.72039137
164Recurrent gram-negative bacterial infections (HP:0005420)1.72024879
165Long foot (HP:0001833)1.71408182
166Femoral bowing (HP:0002980)1.70904375
167Increased CSF protein (HP:0002922)1.70871363
168Mitral valve prolapse (HP:0001634)1.70719198
169Tubulointerstitial nephritis (HP:0001970)1.70472695
170Long clavicles (HP:0000890)1.70281429
171Hyperbilirubinemia (HP:0002904)1.70161372
172Mesomelia (HP:0003027)1.70083128
173Male pseudohermaphroditism (HP:0000037)1.69617472
174Subacute progressive viral hepatitis (HP:0006572)1.69216118
175Impulsivity (HP:0100710)1.67931815
176Hypoplastic iliac wings (HP:0002866)1.67737188
177Abnormal pancreas size (HP:0012094)1.67434162
178Abnormality of the frontal sinuses (HP:0002687)1.67404438
179Congenital hepatic fibrosis (HP:0002612)1.67357105
180Morphological abnormality of the middle ear (HP:0008609)1.65678576
181Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.65406117
182Metaphyseal irregularity (HP:0003025)1.65084750
183Multicystic kidney dysplasia (HP:0000003)1.64948012
184Abnormal biliary tract morphology (HP:0012440)1.64552989
185Menstrual irregularities (HP:0000858)1.64511802
186Skin nodule (HP:0200036)1.63970502
187Neoplasm of the peripheral nervous system (HP:0100007)1.62847113

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.10459681
2LATS13.97204874
3INSRR3.71492984
4EIF2AK33.15471662
5TAOK32.98007904
6NUAK12.87033207
7AKT32.77655796
8IRAK32.67182511
9WEE12.52535136
10VRK22.34054411
11STK32.27590568
12CASK2.10023239
13ADRBK21.99971578
14BLK1.91125617
15IRAK11.89220080
16PINK11.87458318
17CAMK1D1.82283241
18ERBB41.77020050
19MAP3K31.74918079
20TRIB31.73889999
21ZAK1.70848006
22TAF11.70097154
23SIK11.68297143
24FGFR21.64167027
25IRAK21.62421571
26WNK41.61227841
27GRK11.56041129
28PHKG21.55147759
29PHKG11.55147759
30MAP3K141.52848197
31SGK21.51458587
32IRAK41.50619341
33PDGFRB1.41970390
34STK391.40935637
35CDK61.37725739
36FGFR31.37581881
37CAMK1G1.33369987
38NEK21.31245606
39MAP4K21.29928945
40RIPK11.29766073
41FGFR41.27853793
42PAK31.27003700
43PNCK1.25829071
44PLK21.20115956
45NLK1.19191507
46YES11.11740933
47VRK11.09095494
48MAP3K41.07180390
49TNIK1.07176860
50JAK11.04479503
51PRKAA21.00871801
52SGK30.99102364
53EPHA30.97783442
54CDK90.94950598
55PTK60.87940778
56JAK30.87843949
57EIF2AK20.86591472
58FER0.81681101
59MET0.80652249
60EPHB10.79706621
61MAP3K50.79071893
62PRKD20.78750103
63PASK0.76711382
64SGK2230.76400680
65SGK4940.76400680
66RPS6KA40.76250181
67HIPK20.76111974
68ERBB30.75555195
69GSK3A0.74599233
70BCR0.73645547
71TIE10.73116118
72PIK3CG0.73055288
73MAPKAPK30.72017845
74CAMK40.71711214
75WNK10.71641906
76BRSK20.70271426
77CAMKK20.69978638
78CSNK1A1L0.69942936
79PDGFRA0.68929108
80ERN10.68719852
81DDR20.68366664
82DAPK20.67493785
83ABL10.67489035
84BMPR1B0.67412045
85PIK3CA0.67323054
86MAP3K20.66698260
87MST40.66481353
88CLK10.66178012
89MAP3K70.65395509
90MAPK150.64505109
91NTRK30.64194439
92FLT30.64100185
93STK380.64060703
94CHUK0.63786070
95JAK20.63594301
96PRKCH0.62940788
97ERBB20.62317884
98CAMK10.62093453
99MELK0.61598484
100STK240.61441921
101NEK60.60867017
102CHEK20.60638287
103RPS6KA60.59541798
104MAPK130.58947684
105ACVR1B0.57187174
106IKBKB0.56373745
107ADRBK10.55717107
108EGFR0.55137295
109MAPKAPK50.53990038
110ITK0.53346485
111CSNK1G10.53152858
112PLK40.52785042
113PRKAA10.52313547
114CDK30.51727684
115MKNK20.50962876
116PKN10.49967832
117MTOR0.49581579
118NEK90.49413552
119MAPK110.49179430
120EPHB20.47317421
121PTK20.46510317
122RIPK40.46280920
123DYRK30.45759805
124TRIM280.44868155
125TRPM70.44654217
126MAP2K40.44487144
127DMPK0.43303461
128IGF1R0.43136287
129RPS6KB10.42465110
130ABL20.42338541
131OXSR10.41702774
132CSNK1A10.41647368
133CSNK1G20.41288016
134INSR0.40557979
135BRD40.40452150
136PLK30.39745348
137DYRK1A0.39694814
138MAP2K30.39458978
139SGK10.39032142
140PRKCZ0.39016159
141STK110.38367366
142MARK30.37874260
143RPS6KC10.37674740
144RPS6KL10.37674740
145STK38L0.37545473
146PRKCE0.36862859
147MAP2K60.36153867
148MUSK0.36100716
149WNK30.35776515
150TEC0.35562575

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.58889055
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.50816401
3Nitrogen metabolism_Homo sapiens_hsa009103.07614787
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.66684420
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.66297525
6Complement and coagulation cascades_Homo sapiens_hsa046102.61065057
7Arginine biosynthesis_Homo sapiens_hsa002202.25349018
8Basal transcription factors_Homo sapiens_hsa030222.17224578
9Staphylococcus aureus infection_Homo sapiens_hsa051502.05608652
10Tryptophan metabolism_Homo sapiens_hsa003802.04452449
11Sulfur metabolism_Homo sapiens_hsa009201.87866631
12Steroid biosynthesis_Homo sapiens_hsa001001.84439536
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83383612
14Fatty acid degradation_Homo sapiens_hsa000711.82804407
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81379285
16Phototransduction_Homo sapiens_hsa047441.75480861
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.74626680
18PPAR signaling pathway_Homo sapiens_hsa033201.73710720
19Selenocompound metabolism_Homo sapiens_hsa004501.72246110
20Vitamin B6 metabolism_Homo sapiens_hsa007501.71726156
21Lysine degradation_Homo sapiens_hsa003101.66415739
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65366968
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.63908399
24Histidine metabolism_Homo sapiens_hsa003401.61419569
25ABC transporters_Homo sapiens_hsa020101.60708231
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.53342518
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53212883
28Butanoate metabolism_Homo sapiens_hsa006501.49689829
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49627003
30beta-Alanine metabolism_Homo sapiens_hsa004101.47568694
31Peroxisome_Homo sapiens_hsa041461.46468097
32RNA degradation_Homo sapiens_hsa030181.46290258
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.44648093
34Phenylalanine metabolism_Homo sapiens_hsa003601.43196473
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40885507
36Linoleic acid metabolism_Homo sapiens_hsa005911.40390794
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39940812
38Fatty acid metabolism_Homo sapiens_hsa012121.39806814
39Homologous recombination_Homo sapiens_hsa034401.39614528
40Retinol metabolism_Homo sapiens_hsa008301.37070010
41Chemical carcinogenesis_Homo sapiens_hsa052041.36948918
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36417040
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.23769730
44Vitamin digestion and absorption_Homo sapiens_hsa049771.23437210
45Fanconi anemia pathway_Homo sapiens_hsa034601.21356473
46Fatty acid biosynthesis_Homo sapiens_hsa000611.21154858
47Bile secretion_Homo sapiens_hsa049761.17821573
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17640847
49Melanoma_Homo sapiens_hsa052181.12977755
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12458427
51Hedgehog signaling pathway_Homo sapiens_hsa043401.11932256
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11207390
53Propanoate metabolism_Homo sapiens_hsa006401.10315854
54Protein export_Homo sapiens_hsa030601.07735955
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06861084
56Insulin secretion_Homo sapiens_hsa049111.05408717
57Tyrosine metabolism_Homo sapiens_hsa003501.04086676
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03242097
59Insulin resistance_Homo sapiens_hsa049311.02383740
60Fat digestion and absorption_Homo sapiens_hsa049750.98709649
61Starch and sucrose metabolism_Homo sapiens_hsa005000.98601786
62One carbon pool by folate_Homo sapiens_hsa006700.97889358
63TGF-beta signaling pathway_Homo sapiens_hsa043500.97218634
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95785489
65Caffeine metabolism_Homo sapiens_hsa002320.92301498
66Prostate cancer_Homo sapiens_hsa052150.86439314
67Taste transduction_Homo sapiens_hsa047420.85175826
68Regulation of autophagy_Homo sapiens_hsa041400.84740427
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83330986
70Serotonergic synapse_Homo sapiens_hsa047260.82390673
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81411743
72Protein digestion and absorption_Homo sapiens_hsa049740.80583591
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.78014880
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76306050
75Long-term depression_Homo sapiens_hsa047300.73840654
76ECM-receptor interaction_Homo sapiens_hsa045120.72594319
77p53 signaling pathway_Homo sapiens_hsa041150.71594348
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68659573
79Ether lipid metabolism_Homo sapiens_hsa005650.68262061
80FoxO signaling pathway_Homo sapiens_hsa040680.66976342
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65229985
82Glycerolipid metabolism_Homo sapiens_hsa005610.64657233
83Folate biosynthesis_Homo sapiens_hsa007900.63442281
84RNA polymerase_Homo sapiens_hsa030200.62420232
85Type II diabetes mellitus_Homo sapiens_hsa049300.60739426
86Renin secretion_Homo sapiens_hsa049240.60393650
87Hippo signaling pathway_Homo sapiens_hsa043900.60076005
88Prion diseases_Homo sapiens_hsa050200.59839252
89Basal cell carcinoma_Homo sapiens_hsa052170.58258179
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58130408
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58125700
92Dorso-ventral axis formation_Homo sapiens_hsa043200.57896843
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57872256
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.57308955
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56187224
96Arginine and proline metabolism_Homo sapiens_hsa003300.55065431
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54970891
98Circadian entrainment_Homo sapiens_hsa047130.54589352
99Sphingolipid metabolism_Homo sapiens_hsa006000.54291544
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53976906
101Nucleotide excision repair_Homo sapiens_hsa034200.53881458
102Fatty acid elongation_Homo sapiens_hsa000620.53513838
103Adherens junction_Homo sapiens_hsa045200.53030346
104Inositol phosphate metabolism_Homo sapiens_hsa005620.52748938
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51320801
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.48643183
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48111900
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47756376
109Nicotine addiction_Homo sapiens_hsa050330.47492953
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47431873
111TNF signaling pathway_Homo sapiens_hsa046680.47312618
112Small cell lung cancer_Homo sapiens_hsa052220.47069369
113Circadian rhythm_Homo sapiens_hsa047100.44616534
114Ovarian steroidogenesis_Homo sapiens_hsa049130.44234768
115Axon guidance_Homo sapiens_hsa043600.44069504
116Renal cell carcinoma_Homo sapiens_hsa052110.43729189
117Glutamatergic synapse_Homo sapiens_hsa047240.42912041
118Choline metabolism in cancer_Homo sapiens_hsa052310.42683205
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42068492
120Sulfur relay system_Homo sapiens_hsa041220.41487470
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40062756
122Olfactory transduction_Homo sapiens_hsa047400.39162349
123Glucagon signaling pathway_Homo sapiens_hsa049220.37958536
124Dopaminergic synapse_Homo sapiens_hsa047280.37946772
125ErbB signaling pathway_Homo sapiens_hsa040120.37871358
126Purine metabolism_Homo sapiens_hsa002300.37657867
127Amoebiasis_Homo sapiens_hsa051460.37510488
128Metabolic pathways_Homo sapiens_hsa011000.37298077
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36692785
130Cholinergic synapse_Homo sapiens_hsa047250.35908837
131cAMP signaling pathway_Homo sapiens_hsa040240.35709605
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34689453
133Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34677522
134AMPK signaling pathway_Homo sapiens_hsa041520.33496992
135Morphine addiction_Homo sapiens_hsa050320.33418061
136Cocaine addiction_Homo sapiens_hsa050300.33356222
137Chronic myeloid leukemia_Homo sapiens_hsa052200.33121676
138Oxytocin signaling pathway_Homo sapiens_hsa049210.32983849
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.32821612
140Prolactin signaling pathway_Homo sapiens_hsa049170.32676048
141MicroRNAs in cancer_Homo sapiens_hsa052060.31652036
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30271210
143Hepatitis C_Homo sapiens_hsa051600.29042970
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27962707
145Systemic lupus erythematosus_Homo sapiens_hsa053220.27296125
146Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25263143
147Focal adhesion_Homo sapiens_hsa045100.25076554
148Malaria_Homo sapiens_hsa051440.23689752
149Pancreatic cancer_Homo sapiens_hsa052120.23386491
150Legionellosis_Homo sapiens_hsa051340.23147578
151Jak-STAT signaling pathway_Homo sapiens_hsa046300.22681341
152Measles_Homo sapiens_hsa051620.22037976
153Endometrial cancer_Homo sapiens_hsa052130.20167734
154Pancreatic secretion_Homo sapiens_hsa049720.19784177

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