DBN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)5.39974271
2pyrimidine nucleobase catabolic process (GO:0006208)5.39754074
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.95470147
4synaptic vesicle maturation (GO:0016188)4.89490878
5cell migration in hindbrain (GO:0021535)4.83475592
6paraxial mesoderm development (GO:0048339)4.76599397
7locomotory exploration behavior (GO:0035641)4.69125938
8vocalization behavior (GO:0071625)4.69013736
9axonal fasciculation (GO:0007413)4.66945165
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.65058567
11planar cell polarity pathway involved in neural tube closure (GO:0090179)4.64058071
12dendritic spine morphogenesis (GO:0060997)4.61623900
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.52323665
14neuron recognition (GO:0008038)4.46501719
15regulation of synapse structural plasticity (GO:0051823)4.36723760
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.35234312
17regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.32989519
18protein localization to synapse (GO:0035418)4.31340132
19regulation of glutamate receptor signaling pathway (GO:1900449)4.23852533
20nucleobase catabolic process (GO:0046113)4.21112928
21central nervous system projection neuron axonogenesis (GO:0021952)4.20476905
22neuron cell-cell adhesion (GO:0007158)4.18281555
23positive regulation of synapse maturation (GO:0090129)4.13402340
24exploration behavior (GO:0035640)4.04750332
25synaptic vesicle docking involved in exocytosis (GO:0016081)4.04440575
26dendrite morphogenesis (GO:0048813)4.02525894
27synaptic vesicle exocytosis (GO:0016079)3.99557715
28regulation of synaptic vesicle exocytosis (GO:2000300)3.88271961
29glutamate secretion (GO:0014047)3.79725910
30convergent extension (GO:0060026)3.76987105
31cerebellar Purkinje cell layer development (GO:0021680)3.73390493
32establishment of nucleus localization (GO:0040023)3.71599748
33negative regulation of microtubule polymerization (GO:0031115)3.65258243
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.64152991
35* regulation of neuronal synaptic plasticity (GO:0048168)3.62439830
36ionotropic glutamate receptor signaling pathway (GO:0035235)3.59835663
37response to pheromone (GO:0019236)3.50360581
38regulation of dendritic spine morphogenesis (GO:0061001)3.40899597
39regulation of synaptic vesicle transport (GO:1902803)3.38256853
40positive regulation of dendritic spine morphogenesis (GO:0061003)3.36864561
41neuronal ion channel clustering (GO:0045161)3.32285017
42postsynaptic membrane organization (GO:0001941)3.32057035
43Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.31740696
44axon extension (GO:0048675)3.31642420
45nucleosome disassembly (GO:0006337)3.29873409
46protein-DNA complex disassembly (GO:0032986)3.29873409
47neurotransmitter secretion (GO:0007269)3.25681750
48auditory behavior (GO:0031223)3.25674396
49dendritic spine organization (GO:0097061)3.25151151
50central nervous system neuron axonogenesis (GO:0021955)3.20271011
51regulation of establishment of planar polarity (GO:0090175)3.18582333
52protein heterotrimerization (GO:0070208)3.17060568
53synaptic transmission, glutamatergic (GO:0035249)3.14078476
54peptidyl-arginine omega-N-methylation (GO:0035247)3.13627858
55neuromuscular process controlling balance (GO:0050885)3.13573617
56negative regulation of chondrocyte differentiation (GO:0032331)3.13110616
57G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.12524218
58positive regulation of dendritic spine development (GO:0060999)3.07573672
59glial cell proliferation (GO:0014009)3.07536762
60establishment of apical/basal cell polarity (GO:0035089)3.04378707
61glutamate receptor signaling pathway (GO:0007215)3.04041501
62cell migration involved in sprouting angiogenesis (GO:0002042)3.02873639
63regulation of synapse maturation (GO:0090128)3.00906980
64neurotransmitter-gated ion channel clustering (GO:0072578)2.99330889
65cerebellum development (GO:0021549)2.98559455
66neuron projection extension (GO:1990138)2.98532035
67cochlea morphogenesis (GO:0090103)2.97528878
68innervation (GO:0060384)2.96092022
69protein retention in ER lumen (GO:0006621)2.95647715
70regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.94346538
71histone arginine methylation (GO:0034969)2.94047696
72proline transport (GO:0015824)2.93690469
73hippocampus development (GO:0021766)2.92922819
74positive regulation of synaptic transmission, GABAergic (GO:0032230)2.92630735
75regulation of synapse organization (GO:0050807)2.92097833
76cerebellar Purkinje cell differentiation (GO:0021702)2.89364565
77positive regulation of synapse assembly (GO:0051965)2.89289618
78dopamine receptor signaling pathway (GO:0007212)2.89153192
79regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.88331687
80G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.87170326
81peptidyl-arginine methylation (GO:0018216)2.85954249
82peptidyl-arginine N-methylation (GO:0035246)2.85954249
83establishment or maintenance of monopolar cell polarity (GO:0061339)2.85099105
84establishment of monopolar cell polarity (GO:0061162)2.85099105
85clathrin coat assembly (GO:0048268)2.84641808
86response to auditory stimulus (GO:0010996)2.84605094
87establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.84291156
88positive regulation of axon extension (GO:0045773)2.83872869
89neuron projection extension involved in neuron projection guidance (GO:1902284)2.83020628
90axon extension involved in axon guidance (GO:0048846)2.83020628
91regulation of excitatory postsynaptic membrane potential (GO:0060079)2.82101402
92regulation of axon extension involved in axon guidance (GO:0048841)2.81956992
93regulation of axon extension (GO:0030516)2.81820452
94transmission of nerve impulse (GO:0019226)2.81307481
95activation of protein kinase A activity (GO:0034199)2.80507662
96establishment or maintenance of bipolar cell polarity (GO:0061245)2.80200244
97establishment or maintenance of apical/basal cell polarity (GO:0035088)2.80200244
98regulation of axon guidance (GO:1902667)2.80143964
99synaptic vesicle endocytosis (GO:0048488)2.79207317
100maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.78557443
101negative regulation of axon extension involved in axon guidance (GO:0048843)2.78189207
102cerebral cortex neuron differentiation (GO:0021895)2.78068819
103long-term memory (GO:0007616)2.77981639
104non-canonical Wnt signaling pathway (GO:0035567)2.77748919
105regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.77110995
106positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.76787729
107negative regulation of axon extension (GO:0030517)2.76482863
108negative regulation of catenin import into nucleus (GO:0035414)2.76423378
109semaphorin-plexin signaling pathway (GO:0071526)2.76415998
110negative regulation of axon guidance (GO:1902668)2.76072305
111neuron-neuron synaptic transmission (GO:0007270)2.75833299
112positive regulation of dendrite morphogenesis (GO:0050775)2.75431801
113behavioral defense response (GO:0002209)2.75332404
114behavioral fear response (GO:0001662)2.75332404
115regulation of dendritic spine development (GO:0060998)2.75235912
116regulation of synapse assembly (GO:0051963)2.75186049
117establishment of mitochondrion localization (GO:0051654)2.74839993
118neuron migration (GO:0001764)2.74675186
119regulation of dendrite morphogenesis (GO:0048814)2.74595584
120positive regulation of membrane potential (GO:0045838)2.74079823
121prepulse inhibition (GO:0060134)2.74025956
122positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.74013843
123lung-associated mesenchyme development (GO:0060484)2.73542881
124neuron projection morphogenesis (GO:0048812)2.72083077
125regulation of postsynaptic membrane potential (GO:0060078)2.71950246
126ephrin receptor signaling pathway (GO:0048013)2.70970038
127membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.70592376
128* regulation of synaptic plasticity (GO:0048167)2.69999670
129dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.69437876
130positive regulation of dendrite development (GO:1900006)2.68479471
131regulation of posttranscriptional gene silencing (GO:0060147)2.67823860
132regulation of gene silencing by miRNA (GO:0060964)2.67823860
133regulation of gene silencing by RNA (GO:0060966)2.67823860
134notochord development (GO:0030903)2.66215873
135outer ear morphogenesis (GO:0042473)2.65398406
136polarized epithelial cell differentiation (GO:0030859)2.65182411
137presynaptic membrane assembly (GO:0097105)2.62740272
138establishment of tissue polarity (GO:0007164)2.62090906
139establishment of planar polarity (GO:0001736)2.62090906
140bone trabecula formation (GO:0060346)2.61346055
141mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.58874758
142heterochromatin organization (GO:0070828)2.56655574
143lateral sprouting from an epithelium (GO:0060601)2.55719796
144spinal cord development (GO:0021510)2.53971037
145camera-type eye morphogenesis (GO:0048593)2.53822976
146regulation of NFAT protein import into nucleus (GO:0051532)2.52840805
147ganglion development (GO:0061548)2.51659163
148adherens junction assembly (GO:0034333)2.50863241
149regulation of cell fate specification (GO:0042659)2.48395888
150cytoskeletal anchoring at plasma membrane (GO:0007016)2.46703683
151Golgi transport vesicle coating (GO:0048200)2.46181970
152COPI coating of Golgi vesicle (GO:0048205)2.46181970
153branching involved in salivary gland morphogenesis (GO:0060445)2.40534242
154cell surface receptor signaling pathway involved in heart development (GO:0061311)2.39620069
155neural tube development (GO:0021915)2.38820650
156presynaptic membrane organization (GO:0097090)2.38050608
157kidney mesenchyme development (GO:0072074)2.37681060
158RNA localization (GO:0006403)2.37292936
159negative regulation of cartilage development (GO:0061037)2.36854444
160endothelial cell morphogenesis (GO:0001886)2.36787534
161lens fiber cell development (GO:0070307)2.35087897
162basement membrane organization (GO:0071711)2.34264661
163endodermal cell differentiation (GO:0035987)2.34257239
164negative regulation of cell fate specification (GO:0009996)2.34147339
165adherens junction organization (GO:0034332)2.34003656
166DNA unwinding involved in DNA replication (GO:0006268)2.30540858
167hippo signaling (GO:0035329)2.29780240
168collagen fibril organization (GO:0030199)2.29078442
169mesenchyme morphogenesis (GO:0072132)2.28727273
170regulation of mammary gland epithelial cell proliferation (GO:0033599)2.28704344
171negative regulation of embryonic development (GO:0045992)2.28271708
172establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.27592506
173mitochondrion transport along microtubule (GO:0047497)2.27592506
174establishment of integrated proviral latency (GO:0075713)2.25719361
175lens morphogenesis in camera-type eye (GO:0002089)2.23390143
176somatic stem cell division (GO:0048103)2.21297635
177eye morphogenesis (GO:0048592)2.21043918
178apical protein localization (GO:0045176)2.20204103
179retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.18539859
180L-serine metabolic process (GO:0006563)2.18147872
181cranial nerve morphogenesis (GO:0021602)2.17821658
182renal system development (GO:0072001)2.17185992

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.47990769
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16826200
3EZH2_27304074_Chip-Seq_ESCs_Mouse3.08062188
4RNF2_18974828_ChIP-Seq_MESCs_Mouse3.02627872
5EZH2_18974828_ChIP-Seq_MESCs_Mouse3.02627872
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97090104
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.90559699
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89998484
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.84681191
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.77951163
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.68205008
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.63178438
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.62400806
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56300802
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55686127
16* EZH2_27294783_Chip-Seq_ESCs_Mouse2.54771186
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.52231581
18* RNF2_27304074_Chip-Seq_ESCs_Mouse2.47215555
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.40454084
20REST_21632747_ChIP-Seq_MESCs_Mouse2.34599718
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33884819
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32166207
23ZFP281_18757296_ChIP-ChIP_E14_Mouse2.29488969
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.27926202
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.27742695
26GBX2_23144817_ChIP-Seq_PC3_Human2.24906009
27DROSHA_22980978_ChIP-Seq_HELA_Human2.18838842
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15595395
29REST_18959480_ChIP-ChIP_MESCs_Mouse2.03609768
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.02935245
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.99862944
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.99042549
33CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.90492572
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88144918
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86241861
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.84844793
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.82437483
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79021339
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.77088343
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75974420
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.75493367
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74933681
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.71765704
44RING1B_27294783_Chip-Seq_NPCs_Mouse1.71741346
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.69692727
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.66052118
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.63338827
48* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.62158708
49CLOCK_20551151_ChIP-Seq_293T_Human1.61577938
50ZFP281_27345836_Chip-Seq_ESCs_Mouse1.61019573
51ZNF274_21170338_ChIP-Seq_K562_Hela1.59306494
52KDM2B_26808549_Chip-Seq_K562_Human1.58435617
53TP53_20018659_ChIP-ChIP_R1E_Mouse1.55003999
54* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.53916882
55* ELK3_25401928_ChIP-Seq_HUVEC_Human1.52443358
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49348766
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48526683
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44925519
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40669692
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.40428916
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39546749
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38298435
63TP53_22127205_ChIP-Seq_IMR90_Human1.38260310
64* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38030865
65SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.37219846
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36831984
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36300365
68AR_21572438_ChIP-Seq_LNCaP_Human1.35367256
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.35087239
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.33161410
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31143612
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30771196
73* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26996996
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.25508806
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24767887
76KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22541991
77KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22541991
78KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22541991
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21112055
80NANOG_21062744_ChIP-ChIP_HESCs_Human1.20927492
81RNF2_27304074_Chip-Seq_NSC_Mouse1.20742229
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20727342
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20512075
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20448176
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19839992
86MYC_18555785_ChIP-Seq_MESCs_Mouse1.19408514
87RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16274289
88NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.13652191
89KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12661389
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10307373
91POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10009422
92* AR_19668381_ChIP-Seq_PC3_Human1.09100063
93TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08692368
94ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08209837
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08080221
96ZNF263_19887448_ChIP-Seq_K562_Human1.07578445
97CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07469844
98NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07355758
99CTCF_27219007_Chip-Seq_Bcells_Human1.06681211
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05843754
101POU5F1_16518401_ChIP-PET_MESCs_Mouse1.05464251
102GATA1_26923725_Chip-Seq_HPCs_Mouse1.05303866
103SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04659352
104EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04513580
105THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04213221
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03766012
107POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.03718488
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03587590
109TP63_19390658_ChIP-ChIP_HaCaT_Human1.02951844
110CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02753363
111CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00777906
112TET1_21451524_ChIP-Seq_MESCs_Mouse1.00712976
113* XRN2_22483619_ChIP-Seq_HELA_Human1.00343784
114SOX2_21211035_ChIP-Seq_LN229_Gbm1.00170706
115YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99851381
116IGF1R_20145208_ChIP-Seq_DFB_Human0.98756413
117KDM2B_26808549_Chip-Seq_JURKAT_Human0.98352914
118ISL1_27105846_Chip-Seq_CPCs_Mouse0.98215110
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96304618
120* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95731115
121NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95656533
122SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94208609
123* TET1_21490601_ChIP-Seq_MESCs_Mouse0.93133961
124LXR_22292898_ChIP-Seq_THP-1_Human0.92526267
125TRIM28_21343339_ChIP-Seq_HEK293_Human0.91816036
126SOX3_22085726_ChIP-Seq_NPCs_Mouse0.90406435
127KDM2B_26808549_Chip-Seq_DND41_Human0.89243990
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.86622090
129SMAD3_21741376_ChIP-Seq_EPCs_Human0.86470738
130SMAD4_21799915_ChIP-Seq_A2780_Human0.85789751
131P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85066842
132SMAD3_21741376_ChIP-Seq_ESCs_Human0.82608834
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.82580990
134TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.81981009
135TOP2B_26459242_ChIP-Seq_MCF-7_Human0.79677746
136UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.79461236
137ARNT_22903824_ChIP-Seq_MCF-7_Human0.78521094
138MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.76968519
139CREB1_26743006_Chip-Seq_LNCaP_Human0.76580295
140AR_25329375_ChIP-Seq_VCAP_Human0.75805107
141AHR_22903824_ChIP-Seq_MCF-7_Human0.74381541
142TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73489362
143POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.73489362
144ELK4_26923725_Chip-Seq_MESODERM_Mouse0.73115646
145HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.72848701
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.72566754
147OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.72241504

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.72612115
2MP0003880_abnormal_central_pattern3.74521949
3MP0003635_abnormal_synaptic_transmissio3.28544055
4MP0004270_analgesia3.11554745
5MP0005423_abnormal_somatic_nervous2.98552225
6MP0000778_abnormal_nervous_system2.87396491
7MP0003705_abnormal_hypodermis_morpholog2.87136433
8MP0008438_abnormal_cutaneous_collagen2.82890277
9* MP0002063_abnormal_learning/memory/cond2.78401201
10MP0004272_abnormal_basement_membrane2.64322637
11MP0005257_abnormal_intraocular_pressure2.49512466
12MP0003122_maternal_imprinting2.43450371
13MP0009745_abnormal_behavioral_response2.36312978
14MP0002184_abnormal_innervation2.08382745
15MP0002064_seizures2.07907225
16MP0004858_abnormal_nervous_system2.06384924
17MP0002572_abnormal_emotion/affect_behav2.03311751
18MP0006276_abnormal_autonomic_nervous2.01903801
19MP0001968_abnormal_touch/_nociception1.99484609
20MP0002734_abnormal_mechanical_nocicepti1.98270511
21MP0004811_abnormal_neuron_physiology1.97449158
22MP0002653_abnormal_ependyma_morphology1.93703179
23MP0010030_abnormal_orbit_morphology1.83661104
24MP0000537_abnormal_urethra_morphology1.83262333
25MP0000569_abnormal_digit_pigmentation1.82846998
26MP0000955_abnormal_spinal_cord1.80773933
27MP0001486_abnormal_startle_reflex1.72693748
28MP0002733_abnormal_thermal_nociception1.71614664
29MP0003283_abnormal_digestive_organ1.69079110
30MP0002557_abnormal_social/conspecific_i1.68212952
31MP0002697_abnormal_eye_size1.67912288
32MP0001849_ear_inflammation1.67395707
33MP0009780_abnormal_chondrocyte_physiolo1.64250925
34MP0001440_abnormal_grooming_behavior1.62205400
35MP0003937_abnormal_limbs/digits/tail_de1.60744474
36MP0009046_muscle_twitch1.60056937
37MP0010368_abnormal_lymphatic_system1.59795338
38MP0002735_abnormal_chemical_nociception1.54648079
39MP0002822_catalepsy1.53383205
40MP0002882_abnormal_neuron_morphology1.49112359
41MP0001970_abnormal_pain_threshold1.43568317
42MP0003861_abnormal_nervous_system1.43561297
43MP0009384_cardiac_valve_regurgitation1.42856029
44MP0002152_abnormal_brain_morphology1.42784681
45MP0003385_abnormal_body_wall1.42066025
46MP0002272_abnormal_nervous_system1.40209428
47MP0005623_abnormal_meninges_morphology1.40139039
48MP0002736_abnormal_nociception_after1.39633773
49MP0003566_abnormal_cell_adhesion1.39378783
50MP0005503_abnormal_tendon_morphology1.38558830
51MP0003787_abnormal_imprinting1.38011754
52MP0003121_genomic_imprinting1.37660441
53MP0003329_amyloid_beta_deposits1.37197108
54MP0000762_abnormal_tongue_morphology1.35495652
55MP0002234_abnormal_pharynx_morphology1.33957069
56MP0000534_abnormal_ureter_morphology1.31742543
57MP0002067_abnormal_sensory_capabilities1.30748937
58MP0002909_abnormal_adrenal_gland1.27523990
59MP0000566_synostosis1.27177230
60MP0005499_abnormal_olfactory_system1.26445798
61MP0005394_taste/olfaction_phenotype1.26445798
62MP0003119_abnormal_digestive_system1.25631170
63MP0005187_abnormal_penis_morphology1.23730233
64MP0002085_abnormal_embryonic_tissue1.22798691
65MP0008961_abnormal_basal_metabolism1.22044594
66MP0004885_abnormal_endolymph1.21498255
67MP0001293_anophthalmia1.20888114
68MP0000631_abnormal_neuroendocrine_gland1.20867702
69MP0002084_abnormal_developmental_patter1.20765642
70MP0003942_abnormal_urinary_system1.19844603
71MP0009672_abnormal_birth_weight1.19103899
72MP0001299_abnormal_eye_distance/1.17881276
73MP0002751_abnormal_autonomic_nervous1.17728712
74MP0005386_behavior/neurological_phenoty1.17580111
75MP0004924_abnormal_behavior1.17580111
76MP0008932_abnormal_embryonic_tissue1.16883497
77MP0003279_aneurysm1.16736792
78MP0000751_myopathy1.16685256
79MP0001984_abnormal_olfaction1.16604273
80MP0002066_abnormal_motor_capabilities/c1.14850518
81MP0002092_abnormal_eye_morphology1.14644159
82MP0001501_abnormal_sleep_pattern1.14252541
83MP0005508_abnormal_skeleton_morphology1.13550633
84MP0005645_abnormal_hypothalamus_physiol1.12821714
85MP0003941_abnormal_skin_development1.12679858
86MP0004233_abnormal_muscle_weight1.12427675
87MP0008569_lethality_at_weaning1.12125400
88MP0000049_abnormal_middle_ear1.11900812
89MP0001958_emphysema1.10648487
90MP0000462_abnormal_digestive_system1.10241842
91MP0001529_abnormal_vocalization1.10072968
92MP0000733_abnormal_muscle_development1.09788977
93MP0004197_abnormal_fetal_growth/weight/1.07446790
94MP0000013_abnormal_adipose_tissue1.06874855
95MP0008789_abnormal_olfactory_epithelium1.05665360
96MP0000432_abnormal_head_morphology1.04950571
97MP0001286_abnormal_eye_development1.02900269
98MP0005275_abnormal_skin_tensile1.02106023
99MP0003123_paternal_imprinting1.02029286
100MP0000579_abnormal_nail_morphology1.01968975
101MP0009053_abnormal_anal_canal1.01828478
102MP0002111_abnormal_tail_morphology1.01084714
103MP0002877_abnormal_melanocyte_morpholog1.00984066
104MP0001188_hyperpigmentation0.99598543
105MP0001730_embryonic_growth_arrest0.99064845
106MP0001879_abnormal_lymphatic_vessel0.98907131
107MP0002254_reproductive_system_inflammat0.98727793
108MP0003938_abnormal_ear_development0.97395869
109MP0002114_abnormal_axial_skeleton0.96174667
110MP0002081_perinatal_lethality0.92961719
111MP0002282_abnormal_trachea_morphology0.92718354
112MP0005646_abnormal_pituitary_gland0.92438990
113MP0000767_abnormal_smooth_muscle0.90810218
114MP0002752_abnormal_somatic_nervous0.90171841
115MP0000003_abnormal_adipose_tissue0.89749101
116MP0005076_abnormal_cell_differentiation0.89029524
117MP0003115_abnormal_respiratory_system0.88682820
118MP0002089_abnormal_postnatal_growth/wei0.87704249
119MP0002116_abnormal_craniofacial_bone0.87258711
120MP0002102_abnormal_ear_morphology0.87169601
121MP0001502_abnormal_circadian_rhythm0.87079518
122MP0003137_abnormal_impulse_conducting0.85721265
123MP0005197_abnormal_uvea_morphology0.85381910
124MP0002177_abnormal_outer_ear0.84615332
125MP0002249_abnormal_larynx_morphology0.84521952
126MP0001672_abnormal_embryogenesis/_devel0.84470203
127MP0005380_embryogenesis_phenotype0.84470203
128MP0003755_abnormal_palate_morphology0.84154210
129MP0002069_abnormal_eating/drinking_beha0.84065423
130MP0001348_abnormal_lacrimal_gland0.83464937
131MP0003111_abnormal_nucleus_morphology0.83066111
132MP0001177_atelectasis0.81455337
133MP0006292_abnormal_olfactory_placode0.80775321
134MP0004133_heterotaxia0.80496787
135MP0003567_abnormal_fetal_cardiomyocyte0.80330070
136MP0009250_abnormal_appendicular_skeleto0.79787012
137MP0002932_abnormal_joint_morphology0.78499424
138MP0001340_abnormal_eyelid_morphology0.77099252
139MP0002233_abnormal_nose_morphology0.75732098
140MP0002108_abnormal_muscle_morphology0.75651329
141MP0005248_abnormal_Harderian_gland0.74493443
142MP0003879_abnormal_hair_cell0.73034689
143MP0003315_abnormal_perineum_morphology0.73018313
144MP0004145_abnormal_muscle_electrophysio0.72750920
145MP0000428_abnormal_craniofacial_morphol0.71100380
146MP0001943_abnormal_respiration0.70096637
147MP0003935_abnormal_craniofacial_develop0.69651675
148MP0004085_abnormal_heartbeat0.69550290
149MP0001905_abnormal_dopamine_level0.68293628

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.95304242
2Premature rupture of membranes (HP:0001788)4.60396309
3Protrusio acetabuli (HP:0003179)3.87968395
4Focal motor seizures (HP:0011153)3.76562585
5Focal seizures (HP:0007359)3.57358692
6Abnormality of dentin (HP:0010299)3.02170277
7Ankle clonus (HP:0011448)2.88215609
8Insomnia (HP:0100785)2.85014471
9Hyperacusis (HP:0010780)2.84279794
10Atrophic scars (HP:0001075)2.79112862
11Abnormality of the lower motor neuron (HP:0002366)2.78831160
12Renal duplication (HP:0000075)2.77846109
13Pointed chin (HP:0000307)2.76690220
14Visual hallucinations (HP:0002367)2.71198200
15Epileptic encephalopathy (HP:0200134)2.67110612
16Megalencephaly (HP:0001355)2.66821361
17Ulnar bowing (HP:0003031)2.63249493
18Supranuclear gaze palsy (HP:0000605)2.60346492
19Amblyopia (HP:0000646)2.59223057
20Turricephaly (HP:0000262)2.57190122
21Morphological abnormality of the middle ear (HP:0008609)2.56903806
22Neonatal short-limb short stature (HP:0008921)2.55866783
23Ankle contracture (HP:0006466)2.55406525
24Shallow orbits (HP:0000586)2.54543309
25Genu recurvatum (HP:0002816)2.54385085
26Short 4th metacarpal (HP:0010044)2.51183535
27Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.51183535
28Elfin facies (HP:0004428)2.49199295
29Shoulder girdle muscle weakness (HP:0003547)2.47053732
30Limb dystonia (HP:0002451)2.44098396
31Broad metatarsal (HP:0001783)2.42395743
32Amyotrophic lateral sclerosis (HP:0007354)2.39661162
33Progressive cerebellar ataxia (HP:0002073)2.37089041
34Mutism (HP:0002300)2.34621908
35Drooling (HP:0002307)2.33723409
36Excessive salivation (HP:0003781)2.33723409
37Vitreoretinal degeneration (HP:0000655)2.32101990
38Abnormal eating behavior (HP:0100738)2.28614848
39Coronal craniosynostosis (HP:0004440)2.27448087
40Renovascular hypertension (HP:0100817)2.26843441
41Soft skin (HP:0000977)2.25705289
42Overriding aorta (HP:0002623)2.25342230
43Spinal rigidity (HP:0003306)2.25317404
44Aplasia/Hypoplasia of the brainstem (HP:0007362)2.23991358
45Hypoplasia of the brainstem (HP:0002365)2.23991358
46Biconcave vertebral bodies (HP:0004586)2.20805492
47High anterior hairline (HP:0009890)2.20574160
48Broad-based gait (HP:0002136)2.18882473
49Lissencephaly (HP:0001339)2.18875745
50Poor eye contact (HP:0000817)2.18402465
51Neoplasm of the heart (HP:0100544)2.17314049
52Depression (HP:0000716)2.16821901
53Impaired vibration sensation in the lower limbs (HP:0002166)2.15259497
54Abnormality of the calcaneus (HP:0008364)2.14669807
55Action tremor (HP:0002345)2.14503253
56Failure to thrive in infancy (HP:0001531)2.14343239
57Polyphagia (HP:0002591)2.14284234
58Hemiparesis (HP:0001269)2.13550396
59Torticollis (HP:0000473)2.13394158
60Urinary urgency (HP:0000012)2.12602314
61Wide anterior fontanel (HP:0000260)2.09864100
62Pachygyria (HP:0001302)2.09072013
63Difficulty climbing stairs (HP:0003551)2.07846258
64Flat cornea (HP:0007720)2.07005593
65Genetic anticipation (HP:0003743)2.06083623
66Hepatoblastoma (HP:0002884)2.05697543
67Trigonocephaly (HP:0000243)2.05683238
68Insidious onset (HP:0003587)2.05513095
69Termporal pattern (HP:0011008)2.05513095
70Long palpebral fissure (HP:0000637)2.04572448
71Bowel diverticulosis (HP:0005222)2.02665832
72Fragile skin (HP:0001030)2.02316992
73Calcaneovalgus deformity (HP:0001848)2.01228254
74Apathy (HP:0000741)2.00467961
75Bladder diverticulum (HP:0000015)2.00157342
76Hypoventilation (HP:0002791)2.00116705
77Sacral dimple (HP:0000960)2.00057976
78Cortical dysplasia (HP:0002539)1.99795005
79Abnormal social behavior (HP:0012433)1.98872225
80Impaired social interactions (HP:0000735)1.98872225
81Distal upper limb amyotrophy (HP:0007149)1.98871156
82Upper limb amyotrophy (HP:0009129)1.98871156
83Spastic diplegia (HP:0001264)1.98449654
84Arnold-Chiari malformation (HP:0002308)1.97834546
85Abnormality of the 4th metacarpal (HP:0010012)1.97669198
86Aplasia involving bones of the upper limbs (HP:0009823)1.97314231
87Aplasia of the phalanges of the hand (HP:0009802)1.97314231
88Aplasia involving bones of the extremities (HP:0009825)1.97314231
89Vascular tortuosity (HP:0004948)1.97238630
90Thin ribs (HP:0000883)1.96944093
91Disproportionate tall stature (HP:0001519)1.96160791
92Focal dystonia (HP:0004373)1.94194065
93Broad long bones (HP:0005622)1.93314601
94Obstructive sleep apnea (HP:0002870)1.92807949
95Mitral valve prolapse (HP:0001634)1.92603285
96Febrile seizures (HP:0002373)1.91736133
97Arterial tortuosity (HP:0005116)1.90546525
98Aortic dissection (HP:0002647)1.90455431
99Agitation (HP:0000713)1.89512905
100Vertebral arch anomaly (HP:0008438)1.88754276
101Stereotypic behavior (HP:0000733)1.86981704
102Cutaneous syndactyly (HP:0012725)1.86736465
103Hand muscle atrophy (HP:0009130)1.83733183
104Wormian bones (HP:0002645)1.83630236
105Abnormality of the aortic arch (HP:0012303)1.83352166
106Selective tooth agenesis (HP:0001592)1.83219602
107Absence seizures (HP:0002121)1.82715228
108Diminished motivation (HP:0000745)1.82550510
109Pelvic girdle muscle weakness (HP:0003749)1.82318239
110Deformed tarsal bones (HP:0008119)1.82277424
111Broad thumb (HP:0011304)1.82264476
112Limb-girdle muscle weakness (HP:0003325)1.81982033
113Sleep apnea (HP:0010535)1.81291449
114Atonic seizures (HP:0010819)1.81290177
115Urinary bladder sphincter dysfunction (HP:0002839)1.80865759
116Fetal akinesia sequence (HP:0001989)1.80602149
117Wrist flexion contracture (HP:0001239)1.80329439
118Generalized hypotonia (HP:0001290)1.79826735
119Papilledema (HP:0001085)1.79325517
120Spina bifida occulta (HP:0003298)1.79011156
121Lower limb amyotrophy (HP:0007210)1.78696691
122Breech presentation (HP:0001623)1.78340107
123Annular pancreas (HP:0001734)1.78333711
124Ankyloglossia (HP:0010296)1.77552609
125Generalized tonic-clonic seizures (HP:0002069)1.77485333
126Large eyes (HP:0001090)1.77427484
127Narrow nasal bridge (HP:0000446)1.77158394
128Choanal stenosis (HP:0000452)1.76237604
129Adducted thumb (HP:0001181)1.76210453
130Hyperextensible skin (HP:0000974)1.76167145
131Buphthalmos (HP:0000557)1.75629780
132Bronchomalacia (HP:0002780)1.75348983
133Bowed forearm bones (HP:0003956)1.74358125
134Bowing of the arm (HP:0006488)1.74358125
135Cutaneous finger syndactyly (HP:0010554)1.73873137
136Hallux valgus (HP:0001822)1.73716800
137Megalocornea (HP:0000485)1.73154690
138Back pain (HP:0003418)1.73006585
139Skull defect (HP:0001362)1.72730063
140Broad phalanges of the hand (HP:0009768)1.71411083
141Abnormality of the musculature of the pelvis (HP:0001469)1.71362160
142Abnormality of the hip-girdle musculature (HP:0001445)1.71362160
143Overgrowth (HP:0001548)1.70783635
144Truncal ataxia (HP:0002078)1.70604594
145Craniofacial dystonia (HP:0012179)1.70135140
146Obsessive-compulsive behavior (HP:0000722)1.70047922
147Aqueductal stenosis (HP:0002410)1.69965000
148Cerebral inclusion bodies (HP:0100314)1.68820559
149Congenital glaucoma (HP:0001087)1.68738572
150Broad finger (HP:0001500)1.68701289
151Exotropia (HP:0000577)1.68096391
152Lower limb muscle weakness (HP:0007340)1.67898257
153Spastic gait (HP:0002064)1.67582709
154Hypsarrhythmia (HP:0002521)1.67281606
155EEG with generalized epileptiform discharges (HP:0011198)1.67227910
156Epileptiform EEG discharges (HP:0011182)1.66193696
157Broad phalanx (HP:0006009)1.66092710
158Sporadic (HP:0003745)1.65797833
159Deviation of the hallux (HP:0010051)1.63387778
160Mitral regurgitation (HP:0001653)1.62702149
161Increased nuchal translucency (HP:0010880)1.61826215
162Cervical subluxation (HP:0003308)1.61570558
163Blue sclerae (HP:0000592)1.61334681
164Midface retrusion (HP:0011800)1.60555514
165Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.60016586
166Joint laxity (HP:0001388)1.58594981
167Mildly elevated creatine phosphokinase (HP:0008180)1.58403292
168Hammertoe (HP:0001765)1.57985393
169Cerebral aneurysm (HP:0004944)1.57651286
170Myelomeningocele (HP:0002475)1.55843540
171Broad distal phalanx of finger (HP:0009836)1.55527458

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.28879730
2MAP3K93.46824872
3EPHA43.23566438
4NTRK33.18705544
5KSR12.89342899
6MINK12.78258483
7NTRK22.42797798
8PAK62.39074741
9CDK122.24133790
10MAP3K42.20307778
11EPHB22.13904281
12SIK22.08490306
13LATS22.03988876
14SMG11.94749771
15DAPK21.93388426
16EEF2K1.81822021
17PRKD31.77843209
18KSR21.74831622
19TTN1.74215431
20UHMK11.70211871
21ERBB31.69690970
22MAPK131.69674446
23TYRO31.66725089
24DYRK21.64060862
25SIK31.60815475
26SRPK11.56986922
27CAMKK11.56001894
28MAP2K71.43690100
29LIMK11.39542601
30TRIB31.31655326
31* CDK51.31539014
32PHKG11.28985059
33PHKG21.28985059
34CDK181.26962965
35NTRK11.24574698
36PAK41.22450856
37PAK31.22149738
38ICK1.22037609
39PDGFRA1.21211154
40LATS11.18888237
41BCR1.18837864
42CDK151.18742888
43SIK11.18543690
44CDK141.17167100
45MET1.16229327
46BRD41.16204004
47TIE11.14377257
48PLK21.10179633
49MAP2K41.07600391
50CDK11A1.05437076
51MTOR1.03314406
52DDR21.00451747
53CDC71.00119963
54EPHA20.98760030
55DAPK10.96511568
56ERBB20.95535789
57FLT30.95371564
58TESK10.93570295
59NEK20.90295921
60TAOK10.89727037
61PRPF4B0.88050634
62PNCK0.85875953
63PRKCG0.84789948
64RPS6KA40.84340516
65DYRK1B0.84288982
66ERBB40.84172393
67CSNK1G20.83759636
68MKNK10.83400162
69LMTK20.83166807
70MARK20.82794621
71PRKD20.82789614
72FGFR20.80862063
73DYRK1A0.76994615
74FGFR40.76007281
75FER0.75843772
76DYRK30.75543543
77RET0.75541661
78ALK0.75486134
79WNK30.75281982
80CSNK1G10.74876880
81PRKCZ0.74660271
82AURKA0.74043445
83MOS0.73758931
84RPS6KA20.73308956
85CDK70.71076978
86TTK0.70638917
87CASK0.69072049
88KDR0.68775832
89RIPK10.68764037
90MAP3K100.65879066
91TSSK60.64853007
92STK380.64532095
93BUB10.64370259
94BMX0.64235991
95MAP3K120.63632536
96PTK2B0.63573998
97NEK10.63398461
98TESK20.63380324
99ARAF0.63184789
100STK110.62393870
101CDK190.61647122
102FGFR10.61271257
103TNIK0.61022802
104EPHB10.58896191
105CAMK1G0.57282255
106ROCK10.57030852
107PKN20.56505511
108STK38L0.56192835
109MAP3K20.56009720
110CDC42BPA0.55889861
111PTK60.55113826
112BRSK10.52211438
113MKNK20.52206933
114CDK90.51889318
115CSNK1G30.51595750
116CAMK2A0.51333203
117SGK4940.49770480
118SGK2230.49770480
119MAP3K60.49760584
120CHEK20.49343642
121MAPK90.48721596
122MAP2K20.47958965
123ROCK20.46764425
124CSNK1A1L0.45433912
125MAP2K10.45338705
126AKT20.45323877
127FYN0.44896999
128PDGFRB0.44501546
129CDK20.43546400
130PRKCH0.43372197
131DMPK0.43158053
132PTK20.42369965
133CHEK10.42346766
134GRK50.41848151
135CAMK10.41025313
136TAF10.40587381
137DAPK30.40336628
138SCYL20.39903737
139ILK0.39795881
140PAK20.39303537
141RAF10.38767288
142RPS6KA30.37747419
143SGK10.37536521
144MAPK100.37385163
145CAMK2B0.37295715
146CSNK1E0.35837092

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.75941286
2Synaptic vesicle cycle_Homo sapiens_hsa047212.58425248
3Circadian entrainment_Homo sapiens_hsa047132.27047409
4Axon guidance_Homo sapiens_hsa043602.26367662
5Olfactory transduction_Homo sapiens_hsa047402.21995291
6ECM-receptor interaction_Homo sapiens_hsa045122.16458480
7GABAergic synapse_Homo sapiens_hsa047272.08688014
8Long-term potentiation_Homo sapiens_hsa047202.07246201
9Dopaminergic synapse_Homo sapiens_hsa047282.06711332
10Glutamatergic synapse_Homo sapiens_hsa047242.04950642
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.99155207
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.95051851
13Amphetamine addiction_Homo sapiens_hsa050311.91956568
14Morphine addiction_Homo sapiens_hsa050321.86389652
15Cholinergic synapse_Homo sapiens_hsa047251.84154849
16Gap junction_Homo sapiens_hsa045401.76873371
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73203948
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68911018
19Cocaine addiction_Homo sapiens_hsa050301.68644181
20Glioma_Homo sapiens_hsa052141.56242498
21Oxytocin signaling pathway_Homo sapiens_hsa049211.53812566
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53132251
23Insulin secretion_Homo sapiens_hsa049111.52404023
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.51765320
25GnRH signaling pathway_Homo sapiens_hsa049121.46607758
26Melanogenesis_Homo sapiens_hsa049161.45798690
27Salivary secretion_Homo sapiens_hsa049701.42001839
28Gastric acid secretion_Homo sapiens_hsa049711.39792104
29Long-term depression_Homo sapiens_hsa047301.37359564
30ErbB signaling pathway_Homo sapiens_hsa040121.35494857
31Basal cell carcinoma_Homo sapiens_hsa052171.34463944
32Endometrial cancer_Homo sapiens_hsa052131.33000210
33Estrogen signaling pathway_Homo sapiens_hsa049151.30443781
34Serotonergic synapse_Homo sapiens_hsa047261.28564501
35Biosynthesis of amino acids_Homo sapiens_hsa012301.28285542
36Hedgehog signaling pathway_Homo sapiens_hsa043401.28253058
37Oocyte meiosis_Homo sapiens_hsa041141.25540929
38Hippo signaling pathway_Homo sapiens_hsa043901.24506710
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23759826
40Renin secretion_Homo sapiens_hsa049241.23430767
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23091958
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.22919036
43Thyroid cancer_Homo sapiens_hsa052161.22478800
44Colorectal cancer_Homo sapiens_hsa052101.22267951
45Spliceosome_Homo sapiens_hsa030401.20152987
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.17673008
47Wnt signaling pathway_Homo sapiens_hsa043101.15143789
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09999466
49Protein digestion and absorption_Homo sapiens_hsa049741.09647421
50Taste transduction_Homo sapiens_hsa047421.09335038
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07984446
52Calcium signaling pathway_Homo sapiens_hsa040201.07271973
53VEGF signaling pathway_Homo sapiens_hsa043701.04556527
54Type II diabetes mellitus_Homo sapiens_hsa049301.04487462
55cAMP signaling pathway_Homo sapiens_hsa040241.03196786
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99225173
57Renal cell carcinoma_Homo sapiens_hsa052110.97778801
58Dilated cardiomyopathy_Homo sapiens_hsa054140.97313854
59Cell cycle_Homo sapiens_hsa041100.96370917
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95557246
61TGF-beta signaling pathway_Homo sapiens_hsa043500.94033670
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92970822
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.92763211
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91975066
65Pathways in cancer_Homo sapiens_hsa052000.90897558
66Alcoholism_Homo sapiens_hsa050340.90861399
67Non-small cell lung cancer_Homo sapiens_hsa052230.90592568
68AMPK signaling pathway_Homo sapiens_hsa041520.89414583
69RNA transport_Homo sapiens_hsa030130.89000428
70PI3K-Akt signaling pathway_Homo sapiens_hsa041510.88964102
71mTOR signaling pathway_Homo sapiens_hsa041500.88840678
72Small cell lung cancer_Homo sapiens_hsa052220.88826076
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88282739
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85996201
75Rap1 signaling pathway_Homo sapiens_hsa040150.85228791
76Lysine degradation_Homo sapiens_hsa003100.85178596
77Choline metabolism in cancer_Homo sapiens_hsa052310.82862432
78Dorso-ventral axis formation_Homo sapiens_hsa043200.81722794
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80963737
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80921873
81Sulfur relay system_Homo sapiens_hsa041220.80921711
82Notch signaling pathway_Homo sapiens_hsa043300.80229587
83MAPK signaling pathway_Homo sapiens_hsa040100.79908668
84Chronic myeloid leukemia_Homo sapiens_hsa052200.75097970
85Base excision repair_Homo sapiens_hsa034100.74846586
86Proteoglycans in cancer_Homo sapiens_hsa052050.74158569
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74100071
88Steroid biosynthesis_Homo sapiens_hsa001000.73352136
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72923948
90Ras signaling pathway_Homo sapiens_hsa040140.70781586
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70266113
92Bladder cancer_Homo sapiens_hsa052190.69918548
93Tight junction_Homo sapiens_hsa045300.69510884
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69484170
95Endocytosis_Homo sapiens_hsa041440.69328095
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69143973
97Prostate cancer_Homo sapiens_hsa052150.68723593
98Vibrio cholerae infection_Homo sapiens_hsa051100.68556341
99Shigellosis_Homo sapiens_hsa051310.67010176
100Cardiac muscle contraction_Homo sapiens_hsa042600.66957383
101Selenocompound metabolism_Homo sapiens_hsa004500.66860550
102DNA replication_Homo sapiens_hsa030300.66606614
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66488767
104MicroRNAs in cancer_Homo sapiens_hsa052060.66409068
105Insulin signaling pathway_Homo sapiens_hsa049100.66016949
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.64844003
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64743333
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64695199
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64676733
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.64095254
111Amoebiasis_Homo sapiens_hsa051460.63874805
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62830954
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62796634
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61910020
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61533237
116Focal adhesion_Homo sapiens_hsa045100.61471010
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61443856
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61269418
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.60381397
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59048896
121Prion diseases_Homo sapiens_hsa050200.57204289
122Glucagon signaling pathway_Homo sapiens_hsa049220.56277722
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55775239
124Melanoma_Homo sapiens_hsa052180.55137757
125mRNA surveillance pathway_Homo sapiens_hsa030150.54589515
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54582517
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53869032
128Adherens junction_Homo sapiens_hsa045200.52582648
129Pentose phosphate pathway_Homo sapiens_hsa000300.50461303
130Collecting duct acid secretion_Homo sapiens_hsa049660.50263783
131Galactose metabolism_Homo sapiens_hsa000520.49031275
132Pancreatic cancer_Homo sapiens_hsa052120.47999421

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