DBIL5P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.80517790
2response to pheromone (GO:0019236)4.49276241
3detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.23471259
4platelet dense granule organization (GO:0060155)4.21989226
5behavioral response to nicotine (GO:0035095)4.20315795
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.14552070
7protein-cofactor linkage (GO:0018065)4.09655696
8protein K11-linked deubiquitination (GO:0035871)3.90277353
9retinal rod cell development (GO:0046548)3.75265080
10regulation of cytokine production involved in inflammatory response (GO:1900015)3.62670251
11protein polyglutamylation (GO:0018095)3.62621093
12adaptation of signaling pathway (GO:0023058)3.61703925
13neural tube formation (GO:0001841)3.57370382
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.54977297
15regulation of cilium movement (GO:0003352)3.50795941
16regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.50048772
17establishment of protein localization to Golgi (GO:0072600)3.45952496
18retinal cone cell development (GO:0046549)3.40505531
19axoneme assembly (GO:0035082)3.37367451
20replication fork processing (GO:0031297)3.37272600
21piRNA metabolic process (GO:0034587)3.32837695
22L-fucose catabolic process (GO:0042355)3.29390279
23fucose catabolic process (GO:0019317)3.29390279
24L-fucose metabolic process (GO:0042354)3.29390279
25DNA double-strand break processing (GO:0000729)3.26459424
26protein K6-linked ubiquitination (GO:0085020)3.25155029
27signal peptide processing (GO:0006465)3.21516552
28cornea development in camera-type eye (GO:0061303)3.21407381
29protein targeting to Golgi (GO:0000042)3.20958503
30photoreceptor cell development (GO:0042461)3.16432671
31S-adenosylmethionine metabolic process (GO:0046500)3.14793763
32C4-dicarboxylate transport (GO:0015740)3.14727981
33cytochrome complex assembly (GO:0017004)3.09044534
34proline transport (GO:0015824)3.07742073
35respiratory chain complex IV assembly (GO:0008535)3.05567876
36protein localization to cilium (GO:0061512)3.04741101
37eye photoreceptor cell development (GO:0042462)3.03624857
38cilium morphogenesis (GO:0060271)2.95523147
39glycosphingolipid biosynthetic process (GO:0006688)2.95468267
40behavioral response to ethanol (GO:0048149)2.93840186
41kynurenine metabolic process (GO:0070189)2.92578882
42reflex (GO:0060004)2.90863664
43regulation of glucokinase activity (GO:0033131)2.90419716
44regulation of hexokinase activity (GO:1903299)2.90419716
45regulation of hippo signaling (GO:0035330)2.89632222
46centriole replication (GO:0007099)2.89104163
47head development (GO:0060322)2.88489331
48positive regulation of mitochondrial fission (GO:0090141)2.87814167
49regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.85019492
50regulation of nuclear cell cycle DNA replication (GO:0033262)2.84718438
51glycerophospholipid catabolic process (GO:0046475)2.83710314
52L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.83222978
53inositol phosphate catabolic process (GO:0071545)2.79228708
54ketone body metabolic process (GO:1902224)2.78225685
55preassembly of GPI anchor in ER membrane (GO:0016254)2.78223322
56nephron epithelium morphogenesis (GO:0072088)2.75434256
57nephron tubule morphogenesis (GO:0072078)2.75434256
58cellular ketone body metabolic process (GO:0046950)2.75127875
59indole-containing compound catabolic process (GO:0042436)2.73957599
60indolalkylamine catabolic process (GO:0046218)2.73957599
61tryptophan catabolic process (GO:0006569)2.73957599
62amino acid salvage (GO:0043102)2.72034431
63L-methionine salvage (GO:0071267)2.72034431
64L-methionine biosynthetic process (GO:0071265)2.72034431
65detection of light stimulus involved in sensory perception (GO:0050962)2.71527136
66detection of light stimulus involved in visual perception (GO:0050908)2.71527136
67retrograde transport, vesicle recycling within Golgi (GO:0000301)2.71465081
68GPI anchor metabolic process (GO:0006505)2.71435639
69nucleobase catabolic process (GO:0046113)2.70837426
70alanine transport (GO:0032328)2.70514950
71protein complex biogenesis (GO:0070271)2.70269102
72DNA methylation involved in gamete generation (GO:0043046)2.70086060
73cytidine deamination (GO:0009972)2.69755915
74cytidine metabolic process (GO:0046087)2.69755915
75cytidine catabolic process (GO:0006216)2.69755915
76protein localization to Golgi apparatus (GO:0034067)2.68756750
77photoreceptor cell maintenance (GO:0045494)2.67336729
78negative regulation of synaptic transmission, GABAergic (GO:0032229)2.64632991
79somite development (GO:0061053)2.64381580
80water-soluble vitamin biosynthetic process (GO:0042364)2.63228786
81positive regulation of defense response to virus by host (GO:0002230)2.62534323
82cilium organization (GO:0044782)2.61190120
83polyol catabolic process (GO:0046174)2.61104471
84male meiosis (GO:0007140)2.60315257
85indolalkylamine metabolic process (GO:0006586)2.59683010
86histone H2A acetylation (GO:0043968)2.58787526
87epithelial cilium movement (GO:0003351)2.58718677
88transepithelial transport (GO:0070633)2.57917344
89peptidyl-histidine modification (GO:0018202)2.55566187
90intraciliary transport (GO:0042073)2.54633115
91sleep (GO:0030431)2.53130946
92pyrimidine nucleobase catabolic process (GO:0006208)2.52754717
93protein neddylation (GO:0045116)2.52666605
94embryonic epithelial tube formation (GO:0001838)2.52293667
95male meiosis I (GO:0007141)2.51251573
96postsynaptic membrane organization (GO:0001941)2.50989504
97regulation of translation, ncRNA-mediated (GO:0045974)2.50364333
98negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.50364333
99negative regulation of translation, ncRNA-mediated (GO:0040033)2.50364333
100phosphorylated carbohydrate dephosphorylation (GO:0046838)2.50078577

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.04728601
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.21039630
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.07831555
4VDR_22108803_ChIP-Seq_LS180_Human2.97004804
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.84119923
6IGF1R_20145208_ChIP-Seq_DFB_Human2.79492015
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.71302633
8GBX2_23144817_ChIP-Seq_PC3_Human2.67026259
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.59285104
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43803012
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.20328394
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03151431
13FUS_26573619_Chip-Seq_HEK293_Human1.99322006
14P300_19829295_ChIP-Seq_ESCs_Human1.99081794
15CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98187613
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88218923
17EZH2_22144423_ChIP-Seq_EOC_Human1.88008052
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86330259
19ER_23166858_ChIP-Seq_MCF-7_Human1.85671144
20BCAT_22108803_ChIP-Seq_LS180_Human1.80316362
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78574248
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77374584
23EWS_26573619_Chip-Seq_HEK293_Human1.76812859
24TAF15_26573619_Chip-Seq_HEK293_Human1.74010624
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71324508
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69104200
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68235824
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63721857
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.61854330
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.61439142
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58265851
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58041724
33STAT3_23295773_ChIP-Seq_U87_Human1.55210099
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53647449
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53624575
36CBP_20019798_ChIP-Seq_JUKART_Human1.53624575
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50694807
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47592095
39SMAD4_21799915_ChIP-Seq_A2780_Human1.47321208
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45765158
41IRF1_19129219_ChIP-ChIP_H3396_Human1.45590680
42TCF4_23295773_ChIP-Seq_U87_Human1.45343952
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.42348066
44TP53_22573176_ChIP-Seq_HFKS_Human1.42316096
45TCF4_22108803_ChIP-Seq_LS180_Human1.40929626
46NANOG_19829295_ChIP-Seq_ESCs_Human1.40590683
47SOX2_19829295_ChIP-Seq_ESCs_Human1.40590683
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.40210411
49KLF5_20875108_ChIP-Seq_MESCs_Mouse1.38056042
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37245577
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36639147
52CRX_20693478_ChIP-Seq_RETINA_Mouse1.36269504
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34423170
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.30681618
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30681618
56AR_25329375_ChIP-Seq_VCAP_Human1.29199201
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.28021677
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27098834
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26146504
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26062217
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23585589
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22901698
63P53_22387025_ChIP-Seq_ESCs_Mouse1.22827979
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20509954
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19203475
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18818730
67ELK1_19687146_ChIP-ChIP_HELA_Human1.18374942
68P300_18555785_Chip-Seq_ESCs_Mouse1.18014272
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17160171
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.16648767
71SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16580133
72SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16214117
73STAT3_18555785_Chip-Seq_ESCs_Mouse1.15972105
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.15816371
75AR_21572438_ChIP-Seq_LNCaP_Human1.14932909
76MYC_18940864_ChIP-ChIP_HL60_Human1.14913507
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14877963
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14763424
79OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14605430
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.14186729
81CDX2_22108803_ChIP-Seq_LS180_Human1.13905349
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.12865176
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12278182
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12278182
85RUNX2_22187159_ChIP-Seq_PCA_Human1.12183115
86RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11480011
87EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11420124
88NCOR_22424771_ChIP-Seq_293T_Human1.11199800
89AR_20517297_ChIP-Seq_VCAP_Human1.10804244
90FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10031258
91EST1_17652178_ChIP-ChIP_JURKAT_Human1.08918753
92CMYC_18555785_Chip-Seq_ESCs_Mouse1.08181873
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06688992
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.04030856
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.03947575
96SMAD4_21741376_ChIP-Seq_EPCs_Human1.03316281
97ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03245910
98CTCF_18555785_Chip-Seq_ESCs_Mouse1.02175105
99ETV1_20927104_ChIP-Seq_GIST48_Human1.02074163
100VDR_23849224_ChIP-Seq_CD4+_Human1.02046365

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.17679418
2MP0003195_calcinosis3.21120598
3MP0003787_abnormal_imprinting2.75792203
4MP0006292_abnormal_olfactory_placode2.38300974
5MP0002837_dystrophic_cardiac_calcinosis2.36753325
6MP0001529_abnormal_vocalization2.33973763
7MP0002876_abnormal_thyroid_physiology2.31842316
8MP0005646_abnormal_pituitary_gland2.28536375
9MP0000569_abnormal_digit_pigmentation2.27874290
10MP0006072_abnormal_retinal_apoptosis2.25721519
11MP0004885_abnormal_endolymph2.23980750
12MP0008875_abnormal_xenobiotic_pharmacok2.23101564
13MP0002254_reproductive_system_inflammat2.20665580
14MP0005551_abnormal_eye_electrophysiolog2.19230808
15MP0000427_abnormal_hair_cycle2.12656995
16MP0005645_abnormal_hypothalamus_physiol2.08410913
17MP0002736_abnormal_nociception_after2.05012085
18MP0005253_abnormal_eye_physiology2.02537519
19MP0004147_increased_porphyrin_level2.01740275
20MP0003011_delayed_dark_adaptation1.99033399
21MP0002102_abnormal_ear_morphology1.95050494
22MP0001986_abnormal_taste_sensitivity1.87052822
23MP0005075_abnormal_melanosome_morpholog1.86879059
24MP0001968_abnormal_touch/_nociception1.84568490
25MP0008995_early_reproductive_senescence1.76382871
26MP0000372_irregular_coat_pigmentation1.75045938
27MP0008872_abnormal_physiological_respon1.73027211
28MP0004142_abnormal_muscle_tone1.71453266
29MP0003646_muscle_fatigue1.60767640
30MP0004043_abnormal_pH_regulation1.60069503
31MP0000631_abnormal_neuroendocrine_gland1.57616927
32MP0008789_abnormal_olfactory_epithelium1.53286409
33MP0001501_abnormal_sleep_pattern1.48033113
34MP0009745_abnormal_behavioral_response1.42052633
35MP0004133_heterotaxia1.41091955
36MP0002095_abnormal_skin_pigmentation1.40313983
37MP0003121_genomic_imprinting1.39071244
38MP0002277_abnormal_respiratory_mucosa1.37754351
39MP0002234_abnormal_pharynx_morphology1.37180280
40MP0002933_joint_inflammation1.36791188
41MP0003122_maternal_imprinting1.35490929
42MP0002272_abnormal_nervous_system1.30965763
43MP0003786_premature_aging1.30236637
44MP0002653_abnormal_ependyma_morphology1.30001788
45MP0009046_muscle_twitch1.29781878
46MP0002822_catalepsy1.26128351
47MP0006276_abnormal_autonomic_nervous1.24957394
48MP0005174_abnormal_tail_pigmentation1.24716676
49MP0001486_abnormal_startle_reflex1.22753321
50MP0004924_abnormal_behavior1.21895964
51MP0005386_behavior/neurological_phenoty1.21895964
52MP0003880_abnormal_central_pattern1.20055752
53MP0002638_abnormal_pupillary_reflex1.18959299
54MP0002557_abnormal_social/conspecific_i1.15801660
55MP0000015_abnormal_ear_pigmentation1.14570719
56MP0000778_abnormal_nervous_system1.14279081
57MP0001984_abnormal_olfaction1.10259870
58MP0002163_abnormal_gland_morphology1.06724955
59MP0008775_abnormal_heart_ventricle1.05390810
60MP0005499_abnormal_olfactory_system1.04266495
61MP0005394_taste/olfaction_phenotype1.04266495
62MP0001485_abnormal_pinna_reflex1.03511254
63MP0001764_abnormal_homeostasis1.00574484
64MP0000647_abnormal_sebaceous_gland1.00381283
65MP0003136_yellow_coat_color0.98846976
66MP0003698_abnormal_male_reproductive0.98019870
67MP0005084_abnormal_gallbladder_morpholo0.97882481
68MP0001919_abnormal_reproductive_system0.97738500
69MP0002751_abnormal_autonomic_nervous0.97707782
70MP0005310_abnormal_salivary_gland0.95495051
71MP0004215_abnormal_myocardial_fiber0.93529481
72MP0002210_abnormal_sex_determination0.90613665
73MP0002572_abnormal_emotion/affect_behav0.87311835
74MP0003718_maternal_effect0.87241625
75MP0005647_abnormal_sex_gland0.86424135
76MP0005187_abnormal_penis_morphology0.85198042
77MP0005379_endocrine/exocrine_gland_phen0.83012710
78MP0004742_abnormal_vestibular_system0.82586194
79MP0001929_abnormal_gametogenesis0.81502446
80MP0000653_abnormal_sex_gland0.81199426
81MP0003635_abnormal_synaptic_transmissio0.81129600
82MP0001905_abnormal_dopamine_level0.81056814
83MP0002909_abnormal_adrenal_gland0.80458159
84MP0000955_abnormal_spinal_cord0.80227730
85MP0005195_abnormal_posterior_eye0.80048289
86MP0002229_neurodegeneration0.78937555
87MP0002063_abnormal_learning/memory/cond0.77739707
88MP0009785_altered_susceptibility_to0.77213911
89MP0001502_abnormal_circadian_rhythm0.76837002
90MP0002752_abnormal_somatic_nervous0.76395006
91MP0003119_abnormal_digestive_system0.76326352
92MP0005389_reproductive_system_phenotype0.75778449
93MP0003045_fibrosis0.75144455
94MP0002064_seizures0.72976170
95MP0001145_abnormal_male_reproductive0.71247068
96MP0002168_other_aberrant_phenotype0.71225497
97MP0001970_abnormal_pain_threshold0.69087984
98MP0003938_abnormal_ear_development0.68864859
99MP0000383_abnormal_hair_follicle0.68412918
100MP0005636_abnormal_mineral_homeostasis0.66621683

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.28436266
2Pancreatic fibrosis (HP:0100732)4.12668630
3True hermaphroditism (HP:0010459)4.00877421
4Abnormality of the renal cortex (HP:0011035)3.61821269
5Renal cortical cysts (HP:0000803)3.56643669
6Nephronophthisis (HP:0000090)3.52782363
7Molar tooth sign on MRI (HP:0002419)3.49647229
8Abnormality of midbrain morphology (HP:0002418)3.49647229
9Medial flaring of the eyebrow (HP:0010747)3.23958386
10Congenital stationary night blindness (HP:0007642)3.23820187
11Absent rod-and cone-mediated responses on ERG (HP:0007688)3.03236718
12Abnormal rod and cone electroretinograms (HP:0008323)2.99027827
13Hyperventilation (HP:0002883)2.97047766
14Chronic hepatic failure (HP:0100626)2.96075918
15Abnormality of the renal medulla (HP:0100957)2.94881705
16Abolished electroretinogram (ERG) (HP:0000550)2.91184024
17Pendular nystagmus (HP:0012043)2.86918278
18Intestinal atresia (HP:0011100)2.83036217
19Cystic liver disease (HP:0006706)2.68739364
20Thyroid-stimulating hormone excess (HP:0002925)2.64427650
21Attenuation of retinal blood vessels (HP:0007843)2.62976336
22Amyotrophic lateral sclerosis (HP:0007354)2.60530788
23Sclerocornea (HP:0000647)2.56788018
24Gait imbalance (HP:0002141)2.46846255
25Progressive inability to walk (HP:0002505)2.45601751
26Abnormality of the labia minora (HP:0012880)2.44230359
27Gaze-evoked nystagmus (HP:0000640)2.42110077
28Postaxial foot polydactyly (HP:0001830)2.40901553
29Congenital primary aphakia (HP:0007707)2.38771757
30Nephrogenic diabetes insipidus (HP:0009806)2.36016939
31Anencephaly (HP:0002323)2.33392126
32Polydipsia (HP:0001959)2.31640014
33Abnormal drinking behavior (HP:0030082)2.31640014
34Recurrent cutaneous fungal infections (HP:0011370)2.29297010
35Chronic mucocutaneous candidiasis (HP:0002728)2.29297010
36Neoplasm of the adrenal cortex (HP:0100641)2.28256727
37Type II lissencephaly (HP:0007260)2.24347414
38Congenital hepatic fibrosis (HP:0002612)2.22562744
39Volvulus (HP:0002580)2.20327084
40Broad-based gait (HP:0002136)2.18299328
41Hypothermia (HP:0002045)2.15430008
42Aplasia/Hypoplasia of the tongue (HP:0010295)2.14389644
43Genital tract atresia (HP:0001827)2.13776678
44Aplasia/Hypoplasia of the spleen (HP:0010451)2.13660570
45Acute necrotizing encephalopathy (HP:0006965)2.08164237
46Increased CSF lactate (HP:0002490)2.07904616
47Tubular atrophy (HP:0000092)2.05904840
48Focal seizures (HP:0007359)2.03762020
49Disproportionate short-trunk short stature (HP:0003521)2.02810632
50Mitochondrial inheritance (HP:0001427)2.02633814
51Vaginal atresia (HP:0000148)2.02146359
52Hypomagnesemia (HP:0002917)1.98345617
53Furrowed tongue (HP:0000221)1.97771501
54Pachygyria (HP:0001302)1.97386314
55Inability to walk (HP:0002540)1.97079935
56Cheilitis (HP:0100825)1.94819440
57Postaxial hand polydactyly (HP:0001162)1.93971251
58Acute encephalopathy (HP:0006846)1.93858810
59Aqueductal stenosis (HP:0002410)1.93533832
60Abnormality of macular pigmentation (HP:0008002)1.92732556
61Asplenia (HP:0001746)1.92698066
62Enlarged kidneys (HP:0000105)1.92507443
63Increased corneal curvature (HP:0100692)1.91920921
64Keratoconus (HP:0000563)1.91920921
65Broad alveolar ridges (HP:0000187)1.89942963
66Male pseudohermaphroditism (HP:0000037)1.89762003
67Lissencephaly (HP:0001339)1.89731853
68Widely spaced teeth (HP:0000687)1.89174632
69Progressive macrocephaly (HP:0004481)1.89080119
70Median cleft lip (HP:0000161)1.85362942
71Cerebellar dysplasia (HP:0007033)1.84930600
72Aplasia/Hypoplasia of the tibia (HP:0005772)1.84649534
73Methylmalonic aciduria (HP:0012120)1.80570880
74Absent speech (HP:0001344)1.78979750
75Abnormal respiratory motile cilium morphology (HP:0005938)1.78644332
76Abnormal respiratory epithelium morphology (HP:0012253)1.78644332
77IgG deficiency (HP:0004315)1.78640672
78Astigmatism (HP:0000483)1.78353664
79Bony spicule pigmentary retinopathy (HP:0007737)1.77885391
80Abnormal biliary tract physiology (HP:0012439)1.77555843
81Bile duct proliferation (HP:0001408)1.77555843
82Small hand (HP:0200055)1.76656957
83Clumsiness (HP:0002312)1.76121777
84Methylmalonic acidemia (HP:0002912)1.72474369
85Abnormality of the fovea (HP:0000493)1.72068248
86Poor coordination (HP:0002370)1.71967967
87Oligohydramnios (HP:0001562)1.71834250
88Chorioretinal atrophy (HP:0000533)1.70603816
89Aplasia/Hypoplasia of the sternum (HP:0006714)1.68108933
90Occipital encephalocele (HP:0002085)1.67216889
91Lipid accumulation in hepatocytes (HP:0006561)1.67207016
92Retinitis pigmentosa (HP:0000510)1.66675254
93Pancreatic islet-cell hyperplasia (HP:0004510)1.66128814
94Narrow forehead (HP:0000341)1.65350798
95Aplasia/hypoplasia of the uterus (HP:0008684)1.65184751
96Cutaneous melanoma (HP:0012056)1.65123662
97Progressive microcephaly (HP:0000253)1.64458652
98Polyuria (HP:0000103)1.63912168
99Preaxial hand polydactyly (HP:0001177)1.62945821
100Optic disc pallor (HP:0000543)1.62098010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.28798006
2TXK3.37255949
3ACVR1B3.26140499
4WNK33.11756465
5WNK43.02442318
6PINK12.95667985
7ADRBK22.44443575
8ZAK2.27603792
9NUAK12.25995717
10MAP4K22.21339197
11STK392.10369887
12MAPK131.96495986
13BCR1.79638102
14OXSR11.74720697
15TRIM281.67755168
16BMPR1B1.66187050
17GRK11.64158864
18TLK11.61816502
19CASK1.60991518
20MAP3K41.54901350
21ERBB31.46914498
22TAOK31.41225539
23DAPK21.39023172
24WEE11.32514589
25PHKG21.29251620
26PHKG11.29251620
27MST41.27001417
28PAK31.20581818
29AKT31.19688696
30EPHA31.18303634
31CSNK1G21.14407113
32MARK11.05944041
33INSRR1.02833339
34IRAK11.01047198
35STK38L0.99475772
36NTRK30.98373041
37CSNK1G30.92634826
38PNCK0.88954181
39NEK10.88497420
40DYRK20.86559240
41PRKCE0.83885656
42PKN10.82966705
43FER0.81736164
44MKNK20.78547855
45PRKD30.76301685
46CSNK1A1L0.75962754
47CSNK1G10.75836470
48IKBKB0.74406212
49MINK10.74167021
50MAPKAPK30.73734688
51PTK2B0.72672876
52TNK20.72395307
53PLK30.70205203
54ADRBK10.65979051
55CLK10.65297000
56SIK30.65022073
57VRK10.63459733
58PRKCQ0.61066178
59MUSK0.60978135
60PLK40.59473047
61MAP2K70.59288251
62SGK20.59146362
63PRKCG0.59035797
64LIMK10.58153711
65BRSK20.57509953
66TEC0.57489511
67PRKCZ0.56681661
68FGFR20.54960865
69PBK0.54482029
70ATR0.54413477
71CHUK0.54210069
72LMTK20.53734358
73SIK20.52028184
74ITK0.50985873
75MAP2K20.47427843
76BCKDK0.46293069
77FES0.44544388
78WNK10.42926567
79EPHB20.41703297
80CSNK1A10.41318716
81EPHA40.41223426
82PLK20.41181792
83STK30.40581113
84STK110.40184724
85MAP2K60.40160710
86SGK4940.39672356
87SGK2230.39672356
88PRKCH0.38721982
89CSNK1D0.37968908
90ABL10.37470588
91MKNK10.36798697
92IGF1R0.35183339
93PRKACA0.34675444
94CAMK2A0.33936649
95ATM0.33809758
96NTRK20.33806820
97PLK10.33270163
98IKBKE0.32948073
99TNIK0.32797662
100STK160.32399375

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.49489730
2Nitrogen metabolism_Homo sapiens_hsa009102.70727847
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.68603563
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.50893918
5Phototransduction_Homo sapiens_hsa047442.48482407
6Linoleic acid metabolism_Homo sapiens_hsa005912.44648546
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.39724527
8Fanconi anemia pathway_Homo sapiens_hsa034602.37563131
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.29895201
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.04761189
11Butanoate metabolism_Homo sapiens_hsa006502.04150757
12Ether lipid metabolism_Homo sapiens_hsa005652.04033516
13Homologous recombination_Homo sapiens_hsa034402.00051215
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98554425
15Selenocompound metabolism_Homo sapiens_hsa004501.88633718
16Oxidative phosphorylation_Homo sapiens_hsa001901.87527806
17Protein export_Homo sapiens_hsa030601.86934739
18Collecting duct acid secretion_Homo sapiens_hsa049661.80945682
19Basal transcription factors_Homo sapiens_hsa030221.77077151
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73595037
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65739229
22ABC transporters_Homo sapiens_hsa020101.64833729
23Propanoate metabolism_Homo sapiens_hsa006401.51912033
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49691638
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.48389903
26Nicotine addiction_Homo sapiens_hsa050331.45090315
27Tryptophan metabolism_Homo sapiens_hsa003801.43427797
28Parkinsons disease_Homo sapiens_hsa050121.33053257
29RNA polymerase_Homo sapiens_hsa030201.30531881
30RNA degradation_Homo sapiens_hsa030181.26377559
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25097358
32Peroxisome_Homo sapiens_hsa041461.22952164
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.18155444
34One carbon pool by folate_Homo sapiens_hsa006701.14048063
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12164682
36Primary immunodeficiency_Homo sapiens_hsa053401.09639600
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09264310
38Olfactory transduction_Homo sapiens_hsa047401.07718994
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.06745143
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04832695
41Taste transduction_Homo sapiens_hsa047421.03051881
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.01923032
43Glycerolipid metabolism_Homo sapiens_hsa005611.01655036
44Dorso-ventral axis formation_Homo sapiens_hsa043201.01216439
45Chemical carcinogenesis_Homo sapiens_hsa052041.00883198
46Proteasome_Homo sapiens_hsa030500.95138293
47Retinol metabolism_Homo sapiens_hsa008300.95048049
48Regulation of autophagy_Homo sapiens_hsa041400.94095437
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92484634
50Sulfur metabolism_Homo sapiens_hsa009200.88875582
51Morphine addiction_Homo sapiens_hsa050320.87257852
52Fatty acid elongation_Homo sapiens_hsa000620.85473619
53Insulin secretion_Homo sapiens_hsa049110.83806357
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82542400
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82475828
56Mineral absorption_Homo sapiens_hsa049780.81524813
57Ovarian steroidogenesis_Homo sapiens_hsa049130.80672968
58Circadian rhythm_Homo sapiens_hsa047100.80319066
59Huntingtons disease_Homo sapiens_hsa050160.74811629
60Rheumatoid arthritis_Homo sapiens_hsa053230.72739545
61Circadian entrainment_Homo sapiens_hsa047130.72113092
62Arachidonic acid metabolism_Homo sapiens_hsa005900.70645678
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68751471
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68736483
65GABAergic synapse_Homo sapiens_hsa047270.67454572
66Salivary secretion_Homo sapiens_hsa049700.66343549
67Nucleotide excision repair_Homo sapiens_hsa034200.66156399
68Non-homologous end-joining_Homo sapiens_hsa034500.65679321
69Dopaminergic synapse_Homo sapiens_hsa047280.65336291
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64424615
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.64289488
72Serotonergic synapse_Homo sapiens_hsa047260.63820354
73Metabolic pathways_Homo sapiens_hsa011000.59628035
74Fat digestion and absorption_Homo sapiens_hsa049750.58841523
75beta-Alanine metabolism_Homo sapiens_hsa004100.57603533
76Glutamatergic synapse_Homo sapiens_hsa047240.56737184
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56658773
78Antigen processing and presentation_Homo sapiens_hsa046120.55372723
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55224617
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55207354
81Alzheimers disease_Homo sapiens_hsa050100.55035384
82Type I diabetes mellitus_Homo sapiens_hsa049400.53731805
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52036648
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51337399
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.50864885
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48519965
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47278325
88Fatty acid degradation_Homo sapiens_hsa000710.46228328
89Fatty acid metabolism_Homo sapiens_hsa012120.46114559
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44550345
91Long-term depression_Homo sapiens_hsa047300.42815446
92Synaptic vesicle cycle_Homo sapiens_hsa047210.41556948
93Arginine and proline metabolism_Homo sapiens_hsa003300.41082001
94Graft-versus-host disease_Homo sapiens_hsa053320.40295586
95Mismatch repair_Homo sapiens_hsa034300.39400279
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38875711
97Cocaine addiction_Homo sapiens_hsa050300.36256736
98Calcium signaling pathway_Homo sapiens_hsa040200.35416203
99Purine metabolism_Homo sapiens_hsa002300.34310221
100Histidine metabolism_Homo sapiens_hsa003400.34186162

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