DBF4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a regulator of the cell division cycle 7 homolog (S. cerevisiae) protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and, in complex with the cell division cycle 7 homolog (S. cerevisiae) protein, may facilitate M phase progression. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication checkpoint (GO:0000076)4.62837045
2mitotic sister chromatid segregation (GO:0000070)4.56439513
3meiotic chromosome segregation (GO:0045132)4.35766146
4sister chromatid segregation (GO:0000819)4.31581649
5microtubule depolymerization (GO:0007019)3.99028225
6DNA strand elongation involved in DNA replication (GO:0006271)3.93865994
7DNA replication initiation (GO:0006270)3.86802373
8DNA strand elongation (GO:0022616)3.77183349
9regulation of DNA endoreduplication (GO:0032875)3.75834590
10regulation of centriole replication (GO:0046599)3.67920741
11DNA unwinding involved in DNA replication (GO:0006268)3.66258519
12telomere maintenance via semi-conservative replication (GO:0032201)3.65012523
13pseudouridine synthesis (GO:0001522)3.55446664
14replication fork processing (GO:0031297)3.53796338
15* regulation of nuclear cell cycle DNA replication (GO:0033262)3.53478372
16regulation of centrosome cycle (GO:0046605)3.52946494
17protein localization to kinetochore (GO:0034501)3.45344157
18mitotic chromosome condensation (GO:0007076)3.38922368
19recombinational repair (GO:0000725)3.38661653
20double-strand break repair via homologous recombination (GO:0000724)3.38480544
21somatic hypermutation of immunoglobulin genes (GO:0016446)3.34661010
22somatic diversification of immune receptors via somatic mutation (GO:0002566)3.34661010
23protein K6-linked ubiquitination (GO:0085020)3.34489833
24chromatin remodeling at centromere (GO:0031055)3.32152715
25chromosome condensation (GO:0030261)3.31955823
26synapsis (GO:0007129)3.29407402
27DNA replication-dependent nucleosome assembly (GO:0006335)3.27497976
28DNA replication-dependent nucleosome organization (GO:0034723)3.27497976
29folic acid-containing compound biosynthetic process (GO:0009396)3.26268700
30regulation of centrosome duplication (GO:0010824)3.23556410
31maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.22386322
32translesion synthesis (GO:0019985)3.21786158
33mitotic sister chromatid cohesion (GO:0007064)3.21356530
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17854196
35protein localization to chromosome, centromeric region (GO:0071459)3.17060990
36telomere maintenance via recombination (GO:0000722)3.16940679
37CENP-A containing nucleosome assembly (GO:0034080)3.16888907
38nucleotide-excision repair, DNA gap filling (GO:0006297)3.14011724
39mitotic recombination (GO:0006312)3.12765022
40mitotic nuclear envelope disassembly (GO:0007077)3.11912793
41regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.08939293
42reciprocal DNA recombination (GO:0035825)3.03354916
43reciprocal meiotic recombination (GO:0007131)3.03354916
44microtubule polymerization or depolymerization (GO:0031109)3.02016544
45negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.01623890
46mitochondrial RNA metabolic process (GO:0000959)3.01512601
47DNA packaging (GO:0006323)3.01277141
48nucleobase biosynthetic process (GO:0046112)3.00826399
49kinetochore organization (GO:0051383)2.98350578
50postreplication repair (GO:0006301)2.98030511
51tRNA modification (GO:0006400)2.95840159
52male meiosis I (GO:0007141)2.94078651
53centriole replication (GO:0007099)2.92771857
54histone exchange (GO:0043486)2.92344259
55maturation of 5.8S rRNA (GO:0000460)2.90960446
56negative regulation of DNA-dependent DNA replication (GO:2000104)2.90329206
57DNA strand renaturation (GO:0000733)2.89724283
58DNA topological change (GO:0006265)2.88700434
59sister chromatid cohesion (GO:0007062)2.88683477
60nuclear pore complex assembly (GO:0051292)2.87620966
61response to pheromone (GO:0019236)2.83173060
62negative regulation of mRNA processing (GO:0050686)2.82976228
63DNA recombination (GO:0006310)2.81818387
64mitotic metaphase plate congression (GO:0007080)2.79904477
65piRNA metabolic process (GO:0034587)2.78365930
66nuclear pore organization (GO:0006999)2.78001963
67chromosome segregation (GO:0007059)2.76373694
68nuclear envelope disassembly (GO:0051081)2.76223204
69membrane disassembly (GO:0030397)2.76223204
70attachment of spindle microtubules to kinetochore (GO:0008608)2.75693318
71DNA synthesis involved in DNA repair (GO:0000731)2.75613386
72histone H2A acetylation (GO:0043968)2.75330119
73DNA methylation involved in gamete generation (GO:0043046)2.73534408
74regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.72999001
75regulation of mitotic spindle checkpoint (GO:1903504)2.72999001
76peptidyl-histidine modification (GO:0018202)2.72151318
77double-strand break repair (GO:0006302)2.72088028
78heterochromatin organization (GO:0070828)2.71262244
79chromatin assembly (GO:0031497)2.70572955
80kinetochore assembly (GO:0051382)2.69810400
81centrosome organization (GO:0051297)2.68369269
82chromosome organization involved in meiosis (GO:0070192)2.67649562
83DNA conformation change (GO:0071103)2.66776332
84regulation of histone H3-K4 methylation (GO:0051569)2.64961172
85DNA replication (GO:0006260)2.64886295
86telomere maintenance via telomere lengthening (GO:0010833)2.64711868
87positive regulation of chromosome segregation (GO:0051984)2.63725507
88viral mRNA export from host cell nucleus (GO:0046784)2.63715379
89* regulation of DNA-dependent DNA replication (GO:0090329)2.62334610
90DNA double-strand break processing (GO:0000729)2.61848765
91protein localization to chromosome (GO:0034502)2.61393752
92DNA replication-independent nucleosome assembly (GO:0006336)2.60671705
93DNA replication-independent nucleosome organization (GO:0034724)2.60671705
94regulation of mitochondrial translation (GO:0070129)2.59379635
95DNA deamination (GO:0045006)2.57826333
96DNA-dependent DNA replication (GO:0006261)2.57195853
97ribosome biogenesis (GO:0042254)2.56865931
98chromatin assembly or disassembly (GO:0006333)2.55494778
99transcription from mitochondrial promoter (GO:0006390)2.55402619
100rRNA catabolic process (GO:0016075)2.55353348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.26525276
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.02978341
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.94748857
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.64261709
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35294466
6* MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.14893867
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.99330788
8ZNF274_21170338_ChIP-Seq_K562_Hela2.94899584
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.78248592
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.77224396
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.75458431
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.67204112
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.61544869
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58349088
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.48416902
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.28350384
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.23779239
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16337571
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13117075
20XRN2_22483619_ChIP-Seq_HELA_Human2.08126535
21* FOXP3_21729870_ChIP-Seq_TREG_Human2.04621300
22MYC_18940864_ChIP-ChIP_HL60_Human2.04615058
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04563643
24GABP_19822575_ChIP-Seq_HepG2_Human2.04470259
25VDR_23849224_ChIP-Seq_CD4+_Human2.04026370
26TTF2_22483619_ChIP-Seq_HELA_Human2.03389299
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01775198
28KDM5A_27292631_Chip-Seq_BREAST_Human1.98413144
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98064573
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.92980749
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.91037565
32CIITA_25753668_ChIP-Seq_RAJI_Human1.90214214
33DCP1A_22483619_ChIP-Seq_HELA_Human1.86181960
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85956986
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.85108962
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76248506
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67342036
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62525557
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59153238
40E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.58827370
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.58822885
42* ELK1_19687146_ChIP-ChIP_HELA_Human1.47897163
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47566286
44VDR_22108803_ChIP-Seq_LS180_Human1.45535984
45EWS_26573619_Chip-Seq_HEK293_Human1.43066006
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.42554081
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42194492
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42168297
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38653148
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34507835
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26059951
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21315399
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20101305
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17493489
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17202848
56IRF1_19129219_ChIP-ChIP_H3396_Human1.16386979
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13546849
58BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12904359
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12425384
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12143548
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11745614
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11005978
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05898925
64ERA_21632823_ChIP-Seq_H3396_Human1.05758242
65EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03652198
66CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02420361
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01578784
68FUS_26573619_Chip-Seq_HEK293_Human1.00652911
69FOXP1_21924763_ChIP-Seq_HESCs_Human0.99459106
70TP53_22573176_ChIP-Seq_HFKS_Human0.99027849
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98393585
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97839735
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97719491
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96823505
75HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94275223
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91051281
77IGF1R_20145208_ChIP-Seq_DFB_Human0.90266837
78PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90129375
79RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88958181
80ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88764937
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88393257
82HOXB7_26014856_ChIP-Seq_BT474_Human0.87437506
83E2F1_17053090_ChIP-ChIP_MCF-7_Human0.87417604
84PHF8_20622854_ChIP-Seq_HELA_Human0.86534128
85SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85728753
86RAC3_21632823_ChIP-Seq_H3396_Human0.83797692
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83751619
88E2F1_20622854_ChIP-Seq_HELA_Human0.81795584
89SOX2_16153702_ChIP-ChIP_HESCs_Human0.80366047
90CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79204092
91ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78785981
92YY1_22570637_ChIP-Seq_MALME-3M_Human0.78131497
93P53_21459846_ChIP-Seq_SAOS-2_Human0.77167846
94CTBP1_25329375_ChIP-Seq_LNCAP_Human0.76494794
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75958675
96ZFX_18555785_ChIP-Seq_MESCs_Mouse0.71530933
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.69692107
98NCOR_22424771_ChIP-Seq_293T_Human0.69480056
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.68281415
100MYC_22102868_ChIP-Seq_BL_Human0.68273103

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.39170742
2MP0003693_abnormal_embryo_hatching4.10189460
3MP0003111_abnormal_nucleus_morphology3.76552399
4MP0008058_abnormal_DNA_repair3.23615764
5MP0006292_abnormal_olfactory_placode2.92066709
6MP0003077_abnormal_cell_cycle2.77545586
7MP0008057_abnormal_DNA_replication2.76300410
8MP0004957_abnormal_blastocyst_morpholog2.43658925
9MP0008877_abnormal_DNA_methylation2.30755945
10MP0008007_abnormal_cellular_replicative2.27573635
11MP0003786_premature_aging2.10087872
12MP0003718_maternal_effect2.08918661
13MP0008932_abnormal_embryonic_tissue2.03981564
14MP0008995_early_reproductive_senescence1.75744313
15MP0002210_abnormal_sex_determination1.74815449
16MP0002163_abnormal_gland_morphology1.68965290
17MP0001929_abnormal_gametogenesis1.67964197
18MP0003937_abnormal_limbs/digits/tail_de1.64087369
19MP0005645_abnormal_hypothalamus_physiol1.57929029
20MP0002102_abnormal_ear_morphology1.57615665
21MP0003646_muscle_fatigue1.56179854
22MP0003698_abnormal_male_reproductive1.53524831
23MP0002234_abnormal_pharynx_morphology1.50599051
24MP0001145_abnormal_male_reproductive1.42378830
25MP0006072_abnormal_retinal_apoptosis1.42366473
26MP0005410_abnormal_fertilization1.41208504
27MP0000631_abnormal_neuroendocrine_gland1.39199677
28MP0000049_abnormal_middle_ear1.38894750
29MP0001293_anophthalmia1.38619339
30MP0005551_abnormal_eye_electrophysiolog1.38375277
31MP0010307_abnormal_tumor_latency1.36414027
32MP0002938_white_spotting1.36331921
33MP0003136_yellow_coat_color1.35436014
34MP0002160_abnormal_reproductive_system1.35368128
35MP0000653_abnormal_sex_gland1.30740099
36MP0003890_abnormal_embryonic-extraembry1.29137297
37MP0005646_abnormal_pituitary_gland1.26056557
38MP0004133_heterotaxia1.23638591
39MP0000350_abnormal_cell_proliferation1.16099215
40MP0001968_abnormal_touch/_nociception1.13691490
41MP0000427_abnormal_hair_cycle1.13182733
42MP0006035_abnormal_mitochondrial_morpho1.09366959
43MP0003119_abnormal_digestive_system1.08917062
44MP0009046_muscle_twitch1.08914911
45MP0002085_abnormal_embryonic_tissue1.08606068
46MP0001672_abnormal_embryogenesis/_devel1.07459593
47MP0005380_embryogenesis_phenotype1.07459593
48MP0001730_embryonic_growth_arrest1.07118321
49MP0001697_abnormal_embryo_size1.05359142
50MP0000015_abnormal_ear_pigmentation1.04810293
51MP0003943_abnormal_hepatobiliary_system1.02835393
52MP0005379_endocrine/exocrine_gland_phen1.02356669
53MP0002084_abnormal_developmental_patter1.02335963
54MP0005174_abnormal_tail_pigmentation1.01512940
55MP0005253_abnormal_eye_physiology1.00428813
56MP0005389_reproductive_system_phenotype0.99052836
57MP0002161_abnormal_fertility/fecundity0.98342274
58MP0002396_abnormal_hematopoietic_system0.96568411
59MP0002095_abnormal_skin_pigmentation0.93861943
60MP0004147_increased_porphyrin_level0.93274156
61MP0004043_abnormal_pH_regulation0.92930524
62MP0002736_abnormal_nociception_after0.92897442
63MP0000313_abnormal_cell_death0.90556312
64MP0000372_irregular_coat_pigmentation0.90409641
65MP0003861_abnormal_nervous_system0.89653737
66MP0004197_abnormal_fetal_growth/weight/0.88011329
67MP0003878_abnormal_ear_physiology0.87288902
68MP0005377_hearing/vestibular/ear_phenot0.87288902
69MP0002249_abnormal_larynx_morphology0.87135535
70MP0003195_calcinosis0.86045219
71MP0002080_prenatal_lethality0.85311670
72MP0001346_abnormal_lacrimal_gland0.85112589
73MP0000358_abnormal_cell_content/0.84828811
74MP0000566_synostosis0.84174577
75MP0001986_abnormal_taste_sensitivity0.83451725
76MP0008872_abnormal_physiological_respon0.82927475
77MP0001286_abnormal_eye_development0.82771609
78MP0008789_abnormal_olfactory_epithelium0.82687431
79MP0001119_abnormal_female_reproductive0.81182669
80MP0005391_vision/eye_phenotype0.80775158
81MP0003984_embryonic_growth_retardation0.80709030
82MP0009697_abnormal_copulation0.80608540
83MP0000678_abnormal_parathyroid_gland0.79473771
84MP0002111_abnormal_tail_morphology0.79361808
85MP0003567_abnormal_fetal_cardiomyocyte0.77672347
86MP0002088_abnormal_embryonic_growth/wei0.77120097
87MP0003938_abnormal_ear_development0.76615461
88MP0002653_abnormal_ependyma_morphology0.76048934
89MP0001919_abnormal_reproductive_system0.75780962
90MP0010030_abnormal_orbit_morphology0.72908664
91MP0001873_stomach_inflammation0.72284877
92MP0002751_abnormal_autonomic_nervous0.71548943
93MP0002837_dystrophic_cardiac_calcinosis0.71488132
94MP0003699_abnormal_female_reproductive0.71405303
95MP0005075_abnormal_melanosome_morpholog0.71381876
96MP0003950_abnormal_plasma_membrane0.71207499
97MP0002019_abnormal_tumor_incidence0.70756146
98MP0003755_abnormal_palate_morphology0.67840302
99MP0009745_abnormal_behavioral_response0.65903160
100MP0002697_abnormal_eye_size0.65533059

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.58452030
2Chromsome breakage (HP:0040012)4.34820547
3Birth length less than 3rd percentile (HP:0003561)3.75789250
4Patellar aplasia (HP:0006443)3.45171008
5Aplasia/Hypoplasia of the uvula (HP:0010293)3.31906826
6Aplasia/Hypoplasia of the patella (HP:0006498)3.27267997
7Molar tooth sign on MRI (HP:0002419)3.19773222
8Abnormality of midbrain morphology (HP:0002418)3.19773222
9Meckel diverticulum (HP:0002245)3.12326160
10Nephronophthisis (HP:0000090)3.07793033
11Abnormality of the ileum (HP:0001549)3.06902274
12Pancreatic cysts (HP:0001737)2.97443230
13Congenital stationary night blindness (HP:0007642)2.94790842
14Pancreatic fibrosis (HP:0100732)2.94001880
15Ectopic kidney (HP:0000086)2.92489949
16Pendular nystagmus (HP:0012043)2.81979358
17Sloping forehead (HP:0000340)2.66530476
18Cerebellar dysplasia (HP:0007033)2.64477855
19Abnormality of the preputium (HP:0100587)2.63390015
20Abnormality of chromosome stability (HP:0003220)2.62202937
21True hermaphroditism (HP:0010459)2.57940454
22Type II lissencephaly (HP:0007260)2.49349780
23Abnormality of the renal medulla (HP:0100957)2.48980571
24Sclerocornea (HP:0000647)2.36076997
25Small intestinal stenosis (HP:0012848)2.33060886
26Duodenal stenosis (HP:0100867)2.33060886
27Duplicated collecting system (HP:0000081)2.31863266
28Absent radius (HP:0003974)2.31718161
29Aplasia involving forearm bones (HP:0009822)2.31680603
30Absent forearm bone (HP:0003953)2.31680603
31Absent thumb (HP:0009777)2.25143887
32Abnormality of the carotid arteries (HP:0005344)2.24956506
33Short thumb (HP:0009778)2.23872438
34Abnormality of the renal cortex (HP:0011035)2.22443754
35Squamous cell carcinoma (HP:0002860)2.19404633
36Preaxial hand polydactyly (HP:0001177)2.17684910
37Cystic liver disease (HP:0006706)2.17406307
38Attenuation of retinal blood vessels (HP:0007843)2.15485768
39Clubbing of toes (HP:0100760)2.14924743
40Hypoplasia of the pons (HP:0012110)2.14829480
41Abnormality of the labia minora (HP:0012880)2.12400099
42Abnormality of the renal collecting system (HP:0004742)2.10407851
43Small hand (HP:0200055)2.10120297
44Chronic hepatic failure (HP:0100626)2.09920970
45Impulsivity (HP:0100710)2.07804500
46Volvulus (HP:0002580)2.05253296
47Abnormality of the pons (HP:0007361)2.05002584
48Abnormality of DNA repair (HP:0003254)2.04150420
49Horseshoe kidney (HP:0000085)2.04043175
50Bilateral microphthalmos (HP:0007633)2.03288131
51Abnormality of the duodenum (HP:0002246)2.02941200
52Triphalangeal thumb (HP:0001199)2.00400028
53Lissencephaly (HP:0001339)1.99131112
54Tubular atrophy (HP:0000092)1.96712549
55Abnormality of alanine metabolism (HP:0010916)1.94218172
56Hyperalaninemia (HP:0003348)1.94218172
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94218172
58Anencephaly (HP:0002323)1.91240160
59Optic nerve coloboma (HP:0000588)1.89774098
60Homocystinuria (HP:0002156)1.86925028
61Abnormality of homocysteine metabolism (HP:0010919)1.86925028
62Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86496148
63Severe muscular hypotonia (HP:0006829)1.85426386
64Astigmatism (HP:0000483)1.85066875
65Breast hypoplasia (HP:0003187)1.84164266
66Glioma (HP:0009733)1.83150347
67Highly arched eyebrow (HP:0002553)1.80563727
68Broad distal phalanx of finger (HP:0009836)1.80200023
69Absent epiphyses (HP:0010577)1.80134522
70Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.80134522
71Neoplasm of the adrenal cortex (HP:0100641)1.79808763
72Dandy-Walker malformation (HP:0001305)1.79047753
73Abnormality of cochlea (HP:0000375)1.78972594
74Rib fusion (HP:0000902)1.78861251
75Polydipsia (HP:0001959)1.78310467
76Abnormal drinking behavior (HP:0030082)1.78310467
77Abnormal number of erythroid precursors (HP:0012131)1.77548309
78Bony spicule pigmentary retinopathy (HP:0007737)1.76615150
79Abnormal lung lobation (HP:0002101)1.74249845
80Abnormal biliary tract physiology (HP:0012439)1.74228837
81Bile duct proliferation (HP:0001408)1.74228837
82Myelodysplasia (HP:0002863)1.73754103
83Postaxial foot polydactyly (HP:0001830)1.72372101
84Astrocytoma (HP:0009592)1.72003645
85Abnormality of the astrocytes (HP:0100707)1.72003645
86Morphological abnormality of the inner ear (HP:0011390)1.71814395
87Oligodactyly (hands) (HP:0001180)1.71643273
88Genetic anticipation (HP:0003743)1.71447666
89Colon cancer (HP:0003003)1.71254890
90Acute lymphatic leukemia (HP:0006721)1.71002878
91Hypoplastic iliac wings (HP:0002866)1.70080695
92Rectovaginal fistula (HP:0000143)1.69917761
93Rectal fistula (HP:0100590)1.69917761
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69696762
95Abnormal protein N-linked glycosylation (HP:0012347)1.69696762
96Abnormal protein glycosylation (HP:0012346)1.69696762
97Abnormal glycosylation (HP:0012345)1.69696762
98Cleft eyelid (HP:0000625)1.68471007
99Severe visual impairment (HP:0001141)1.66062931
100Retinal dysplasia (HP:0007973)1.65494644

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.08477857
2ZAK3.49799654
3CDC73.40044005
4FRK3.24407274
5PLK42.87352260
6TTK2.63342344
7CDK122.51771460
8VRK22.32579115
9WEE12.29040975
10NEK22.20515687
11CHEK22.17384940
12BMPR1B2.07698442
13NUAK12.05352572
14ADRBK22.03932614
15PNCK2.00393112
16SRPK11.95807424
17ATR1.95734472
18BRSK21.91503422
19WNK41.88180777
20MKNK21.76336190
21TLK11.73499209
22NEK11.72835168
23PLK11.63860303
24CDK81.63066681
25PLK31.49040740
26MKNK11.46383606
27BRSK11.39413854
28CDK71.33484428
29INSRR1.29018807
30MAP4K21.28046530
31CHEK11.24625283
32BRD41.24089602
33EEF2K1.22383727
34VRK11.20197343
35TSSK61.17768736
36CDK41.13539417
37NME11.09622285
38FLT31.09369752
39GRK11.08371864
40AURKB1.06802554
41ATM1.04780034
42WNK31.04518144
43EIF2AK11.02386184
44TAOK31.01018027
45CDK30.94595565
46CSNK1G10.92913044
47CSNK1G30.90297986
48TAF10.88868132
49SIK20.87466954
50CDK10.86396705
51ICK0.84922435
52AURKA0.81501001
53STK30.81152446
54CDK20.81096003
55STK160.80422770
56CSNK1A1L0.79012024
57ACVR1B0.78764334
58MAPKAPK50.77607942
59LATS10.77539292
60PRKCI0.69899401
61CAMK1G0.69513482
62EIF2AK20.68789967
63MAPK110.68331472
64RPS6KB20.65525345
65STK40.62759057
66PASK0.62477228
67RPS6KA40.61865165
68MAP2K60.60488408
69SMG10.59599054
70MAPK130.59356296
71PBK0.58911336
72CDK90.57771629
73PLK20.55197733
74FGFR20.54217990
75KDR0.50881947
76CSNK1G20.49079668
77MAP3K100.48558013
78RPS6KA50.47274658
79DYRK30.46901109
80CLK10.46659230
81CCNB10.44888452
82MAPK140.44118006
83EIF2AK30.43938621
84MUSK0.43931443
85PRKDC0.43793034
86MELK0.43737844
87GSK3B0.42426806
88MAP3K80.42212861
89TRIM280.42080919
90CSNK1E0.41683109
91OXSR10.39384226
92CSNK2A10.38976342
93TGFBR10.37125206
94MAP3K40.37121701
95MAP2K20.36835347
96MTOR0.36560050
97CSNK1D0.34960056
98AKT10.34868107
99MARK30.34864864
100PRKAA10.34552679

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034404.42704948
2DNA replication_Homo sapiens_hsa030304.18151786
3One carbon pool by folate_Homo sapiens_hsa006703.50337552
4Fanconi anemia pathway_Homo sapiens_hsa034603.47386915
5Mismatch repair_Homo sapiens_hsa034303.36225585
6Base excision repair_Homo sapiens_hsa034103.07418025
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.05579765
8Selenocompound metabolism_Homo sapiens_hsa004502.93973437
9RNA polymerase_Homo sapiens_hsa030202.86127334
10Non-homologous end-joining_Homo sapiens_hsa034502.70238818
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.55185506
12Basal transcription factors_Homo sapiens_hsa030222.46698990
13RNA transport_Homo sapiens_hsa030132.43499528
14Cell cycle_Homo sapiens_hsa041102.36241941
15Nucleotide excision repair_Homo sapiens_hsa034202.30800424
16Spliceosome_Homo sapiens_hsa030402.25790684
17Pyrimidine metabolism_Homo sapiens_hsa002402.05820458
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87341568
19RNA degradation_Homo sapiens_hsa030181.86063291
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83685261
21Purine metabolism_Homo sapiens_hsa002301.47685367
22mRNA surveillance pathway_Homo sapiens_hsa030151.46943936
23Phototransduction_Homo sapiens_hsa047441.46370792
24Sulfur relay system_Homo sapiens_hsa041221.40565840
25Lysine degradation_Homo sapiens_hsa003101.29681981
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.27211379
27Proteasome_Homo sapiens_hsa030501.24150721
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15826304
29Nitrogen metabolism_Homo sapiens_hsa009101.08009809
30Butanoate metabolism_Homo sapiens_hsa006501.07792748
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.05762319
32p53 signaling pathway_Homo sapiens_hsa041150.95796972
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94396515
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93483588
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91373291
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90028674
37Ribosome_Homo sapiens_hsa030100.87651355
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86560913
39Oocyte meiosis_Homo sapiens_hsa041140.86080773
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85449690
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83928510
42Protein export_Homo sapiens_hsa030600.81832364
43Ether lipid metabolism_Homo sapiens_hsa005650.81070826
44Folate biosynthesis_Homo sapiens_hsa007900.80733349
45Huntingtons disease_Homo sapiens_hsa050160.79123490
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78892862
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76732175
48Vitamin B6 metabolism_Homo sapiens_hsa007500.75913664
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73103204
50Nicotine addiction_Homo sapiens_hsa050330.72564819
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71742269
52N-Glycan biosynthesis_Homo sapiens_hsa005100.69277127
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.66700280
54Olfactory transduction_Homo sapiens_hsa047400.66274308
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64489488
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.63373676
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62671006
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61983765
59Oxidative phosphorylation_Homo sapiens_hsa001900.61937500
60Taste transduction_Homo sapiens_hsa047420.60547242
61Basal cell carcinoma_Homo sapiens_hsa052170.59936462
62Hedgehog signaling pathway_Homo sapiens_hsa043400.54421683
63Linoleic acid metabolism_Homo sapiens_hsa005910.54357661
64Parkinsons disease_Homo sapiens_hsa050120.53761465
65Metabolic pathways_Homo sapiens_hsa011000.53715586
66Fatty acid biosynthesis_Homo sapiens_hsa000610.53440280
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53128668
68Propanoate metabolism_Homo sapiens_hsa006400.53031591
69Primary immunodeficiency_Homo sapiens_hsa053400.49414354
70ABC transporters_Homo sapiens_hsa020100.47613977
71Steroid biosynthesis_Homo sapiens_hsa001000.47078088
72Hippo signaling pathway_Homo sapiens_hsa043900.46654316
73Epstein-Barr virus infection_Homo sapiens_hsa051690.46503272
74Fatty acid metabolism_Homo sapiens_hsa012120.42813030
75Tryptophan metabolism_Homo sapiens_hsa003800.40712969
76Herpes simplex infection_Homo sapiens_hsa051680.37221878
77Asthma_Homo sapiens_hsa053100.35594249
78Biosynthesis of amino acids_Homo sapiens_hsa012300.35161318
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29190093
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27738523
81HTLV-I infection_Homo sapiens_hsa051660.26926803
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25960793
83Sphingolipid metabolism_Homo sapiens_hsa006000.25832964
84Pyruvate metabolism_Homo sapiens_hsa006200.24865317
85Regulation of autophagy_Homo sapiens_hsa041400.24833343
86Wnt signaling pathway_Homo sapiens_hsa043100.23664340
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22422508
88Peroxisome_Homo sapiens_hsa041460.20847956
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20148550
90MicroRNAs in cancer_Homo sapiens_hsa052060.19740328
91Morphine addiction_Homo sapiens_hsa050320.19264568
92Ovarian steroidogenesis_Homo sapiens_hsa049130.18741642
93Viral carcinogenesis_Homo sapiens_hsa052030.18022499
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.14753089
95Systemic lupus erythematosus_Homo sapiens_hsa053220.12456827
96Insulin secretion_Homo sapiens_hsa049110.12208074
97Arginine and proline metabolism_Homo sapiens_hsa003300.12152546
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.11808586
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.10392718
100Glycerolipid metabolism_Homo sapiens_hsa005610.09983363

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