DAXX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.41467285
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.41467285
3antigen processing and presentation of endogenous antigen (GO:0019883)4.87933340
4type I interferon signaling pathway (GO:0060337)4.54169265
5cellular response to type I interferon (GO:0071357)4.54169265
6response to type I interferon (GO:0034340)4.52675466
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.27713452
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.27713452
9modulation by symbiont of host immune response (GO:0052553)4.27713452
10positive regulation by symbiont of host defense response (GO:0052509)4.27713452
11modulation by symbiont of host defense response (GO:0052031)4.27713452
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.27713452
13DNA strand elongation (GO:0022616)4.21267031
14positive regulation of interferon-alpha production (GO:0032727)4.11732182
15establishment of integrated proviral latency (GO:0075713)4.05071692
16immunoglobulin mediated immune response (GO:0016064)4.02765487
17positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.95887034
18regulation of interferon-alpha production (GO:0032647)3.90449697
19telomere maintenance via semi-conservative replication (GO:0032201)3.85594135
20regulation of type I interferon-mediated signaling pathway (GO:0060338)3.84215819
21response to interferon-alpha (GO:0035455)3.81566420
22positive regulation of gamma-delta T cell activation (GO:0046645)3.73990910
23establishment of viral latency (GO:0019043)3.62466098
24cellular response to virus (GO:0098586)3.54452548
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.53952835
26positive regulation of interferon-beta production (GO:0032728)3.53589751
27B cell mediated immunity (GO:0019724)3.51788809
28mitotic chromosome condensation (GO:0007076)3.48221703
29T cell migration (GO:0072678)3.42161130
30cellular response to interferon-alpha (GO:0035457)3.41632113
31DNA topological change (GO:0006265)3.40196933
32negative regulation of ligase activity (GO:0051352)3.31941658
33negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.31941658
34response to peptidoglycan (GO:0032494)3.31877599
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.30444660
36DNA replication initiation (GO:0006270)3.29119162
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.28902530
38ribosome assembly (GO:0042255)3.28777025
39negative regulation of viral genome replication (GO:0045071)3.27465453
40anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.26548694
41mitotic sister chromatid segregation (GO:0000070)3.23798852
42cellular response to interferon-beta (GO:0035458)3.23092500
43positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.21447447
44interferon-gamma-mediated signaling pathway (GO:0060333)3.19776230
45NIK/NF-kappaB signaling (GO:0038061)3.19721438
46telomere maintenance via recombination (GO:0000722)3.17234150
47mitotic metaphase plate congression (GO:0007080)3.16554132
48natural killer cell mediated cytotoxicity (GO:0042267)3.16359789
49natural killer cell mediated immunity (GO:0002228)3.16359789
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.14418875
51protein maturation by protein folding (GO:0022417)3.08794299
52negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.05025663
53response to host immune response (GO:0052572)3.00736312
54response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.00736312
55regulation of translational termination (GO:0006449)3.00278190
56regulation of RIG-I signaling pathway (GO:0039535)3.00194164
57spliceosomal tri-snRNP complex assembly (GO:0000244)3.00135527
58antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.97806871
59cellular response to zinc ion (GO:0071294)2.95331803
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.93037411
61deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.92863415
62signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.92755052
63intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.92755052
64mitotic recombination (GO:0006312)2.92178293
65signal transduction involved in DNA integrity checkpoint (GO:0072401)2.92080233
66signal transduction involved in DNA damage checkpoint (GO:0072422)2.92080233
67regulation of response to interferon-gamma (GO:0060330)2.91609889
68signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.91398588
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.91398588
70signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.91398588
71protein localization to chromosome, centromeric region (GO:0071459)2.91352548
72positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.90107243
73positive regulation of chemokine biosynthetic process (GO:0045080)2.90023698
74response to interferon-beta (GO:0035456)2.89502745
75cellular response to exogenous dsRNA (GO:0071360)2.87982991
76ribosome biogenesis (GO:0042254)2.86668521
77regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.85180867
78cellular response to interferon-gamma (GO:0071346)2.84721529
79proteasome assembly (GO:0043248)2.83434721
80regulation of gamma-delta T cell activation (GO:0046643)2.83279566
81regulation of cellular amino acid metabolic process (GO:0006521)2.82935419
82peptidyl-arginine omega-N-methylation (GO:0035247)2.82693513
83signal transduction involved in cell cycle checkpoint (GO:0072395)2.82150140
84response to host (GO:0075136)2.81249616
85response to host defenses (GO:0052200)2.81249616
86response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.81249616
87regulation of interferon-beta biosynthetic process (GO:0045357)2.80376428
88positive regulation of ligase activity (GO:0051351)2.78801819
89IMP biosynthetic process (GO:0006188)2.78310531
90sister chromatid segregation (GO:0000819)2.77182695
91regulation of ubiquitin-protein transferase activity (GO:0051438)2.74753480
92regulation of interferon-beta production (GO:0032648)2.72880910
93telomere maintenance via telomere lengthening (GO:0010833)2.71956760
94natural killer cell differentiation (GO:0001779)2.71898957
95negative regulation of interleukin-12 production (GO:0032695)2.71608312
96purine nucleobase biosynthetic process (GO:0009113)2.71238771
97defense response to virus (GO:0051607)2.70770861
98response to muramyl dipeptide (GO:0032495)2.70215650
99regulation of gamma-delta T cell differentiation (GO:0045586)2.69710643
100negative regulation of mRNA processing (GO:0050686)2.67823876
101neutrophil activation involved in immune response (GO:0002283)2.67197230
102maturation of SSU-rRNA (GO:0030490)2.67021255
103macrophage activation involved in immune response (GO:0002281)2.65994205
104regulation of ligase activity (GO:0051340)2.65856052
105regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.64759596
106antigen processing and presentation via MHC class Ib (GO:0002475)2.62775159
107lipopolysaccharide-mediated signaling pathway (GO:0031663)2.62183812
108mitotic nuclear envelope disassembly (GO:0007077)2.60630700
109regulation of interleukin-12 biosynthetic process (GO:0045075)2.60018328
110rRNA transcription (GO:0009303)2.58937350
111heterochromatin organization (GO:0070828)2.57592749
112positive regulation of natural killer cell differentiation (GO:0032825)2.57534650
113negative regulation of mRNA metabolic process (GO:1903312)2.57248415
114viral mRNA export from host cell nucleus (GO:0046784)2.57050229
115cell cycle G1/S phase transition (GO:0044843)2.55440738
116G1/S transition of mitotic cell cycle (GO:0000082)2.55440738
117nuclear pore organization (GO:0006999)2.54678987
118defense response to protozoan (GO:0042832)2.54650619
119mitotic nuclear envelope reassembly (GO:0007084)2.54406943
120nuclear envelope reassembly (GO:0031468)2.54406943
121regulation of double-strand break repair via homologous recombination (GO:0010569)2.54028977
122protein complex localization (GO:0031503)2.53634996
123Arp2/3 complex-mediated actin nucleation (GO:0034314)2.53036968
124base-excision repair (GO:0006284)2.52056911
125negative regulation of viral process (GO:0048525)2.51810186
126pentose-phosphate shunt (GO:0006098)2.51727213
127regulation of helicase activity (GO:0051095)2.50546514
128histone arginine methylation (GO:0034969)2.50081403
129positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.49334862
130ribonucleoprotein complex biogenesis (GO:0022613)2.48076651
131DNA ligation (GO:0006266)2.47883340
132nucleobase biosynthetic process (GO:0046112)2.47873020
133regulation of T-helper 1 cell differentiation (GO:0045625)2.47834732
134regulation of necroptotic process (GO:0060544)2.47487155
135spliceosomal snRNP assembly (GO:0000387)2.47356376
136positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.47207306
137Golgi transport vesicle coating (GO:0048200)2.47170206
138COPI coating of Golgi vesicle (GO:0048205)2.47170206
139cellular response to interleukin-4 (GO:0071353)2.45936253
140regulation of chemokine biosynthetic process (GO:0045073)2.45076157
141regulation of viral genome replication (GO:0045069)2.45006769
142nuclear pore complex assembly (GO:0051292)2.44136295
143regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.43528775
144NADPH regeneration (GO:0006740)2.43430860
145positive regulation of type I interferon production (GO:0032481)2.42978498
146positive regulation of protein import into nucleus, translocation (GO:0033160)2.42934082
147leukocyte aggregation (GO:0070486)2.42902618
148positive regulation of type 2 immune response (GO:0002830)2.42733968
149metaphase plate congression (GO:0051310)2.42661521
150negative regulation of chromosome segregation (GO:0051985)2.42053761
151folic acid-containing compound biosynthetic process (GO:0009396)2.41632477
152nuclear envelope disassembly (GO:0051081)2.40730776
153membrane disassembly (GO:0030397)2.40730776
154response to interferon-gamma (GO:0034341)2.40538251
155DNA replication checkpoint (GO:0000076)2.39859924
156DNA unwinding involved in DNA replication (GO:0006268)2.39623860
157positive regulation of cell cycle arrest (GO:0071158)2.39311755
158negative regulation of RNA splicing (GO:0033119)2.39027053
159nucleotide-excision repair, DNA gap filling (GO:0006297)2.38982536
160IMP metabolic process (GO:0046040)2.38114982
161regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.37766674
162JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.37636852
163lymphocyte mediated immunity (GO:0002449)2.36589851
164formation of translation preinitiation complex (GO:0001731)2.36462846
165negative regulation of protein ubiquitination (GO:0031397)2.36092958
166regulation of spindle organization (GO:0090224)2.35534693
167establishment of chromosome localization (GO:0051303)2.35380215
168nucleobase-containing small molecule interconversion (GO:0015949)2.34929081
169negative regulation of mitotic sister chromatid segregation (GO:0033048)2.34887257
170negative regulation of sister chromatid segregation (GO:0033046)2.34887257
171positive regulation of isotype switching (GO:0045830)2.34337512
172positive regulation of humoral immune response (GO:0002922)2.32373960
173negative regulation of myeloid cell apoptotic process (GO:0033033)2.32196484
174cellular response to dsRNA (GO:0071359)2.32055523
175negative thymic T cell selection (GO:0045060)2.31009014
176positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.30800880
177respiratory burst (GO:0045730)2.30507017
178positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.30153495
179negative regulation by host of viral transcription (GO:0043922)2.29510855
180DNA strand elongation involved in DNA replication (GO:0006271)2.29407159
181response to protozoan (GO:0001562)2.27609977
182positive regulation of antigen processing and presentation (GO:0002579)2.26905566
183granulocyte activation (GO:0036230)2.26733707
184protein localization to kinetochore (GO:0034501)2.25982141

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.00973938
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.62510356
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.22103428
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.57853828
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.55532825
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.32835635
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.19174687
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.53290627
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.52539689
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.43797106
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.42791572
12MYC_22102868_ChIP-Seq_BL_Human2.35876884
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35755668
14* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.34447473
15* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19124183
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.17123704
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.15611463
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14419656
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10394930
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.09501973
21MYC_18555785_ChIP-Seq_MESCs_Mouse1.98590466
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96721151
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95456806
24* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94990002
25VDR_21846776_ChIP-Seq_THP-1_Human1.93540081
26THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91859672
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86264594
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84610173
29* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82089490
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81727589
31MAF_26560356_Chip-Seq_TH1_Human1.80540361
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76440761
33MYB_26560356_Chip-Seq_TH2_Human1.74671381
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.71657955
35* DCP1A_22483619_ChIP-Seq_HELA_Human1.69547327
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.65126168
37SPI1_23547873_ChIP-Seq_NB4_Human1.64674586
38GATA1_22025678_ChIP-Seq_K562_Human1.63767764
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.61988069
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61109385
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60257464
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58143539
43MYB_26560356_Chip-Seq_TH1_Human1.55744232
44* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.54770550
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53854262
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52555808
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48977944
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47965330
49UTX_26944678_Chip-Seq_JUKART_Human1.47510963
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46070090
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45458556
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42522412
53* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42455030
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.42069512
55TTF2_22483619_ChIP-Seq_HELA_Human1.41364126
56SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40517118
57MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40184948
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34453983
59* YY1_21170310_ChIP-Seq_MESCs_Mouse1.34143285
60* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33950259
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.32162787
62MAF_26560356_Chip-Seq_TH2_Human1.29095639
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29094210
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26412429
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.25541802
66* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25191598
67* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24845998
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24553318
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24191555
70XRN2_22483619_ChIP-Seq_HELA_Human1.23846102
71AR_21909140_ChIP-Seq_LNCAP_Human1.23410470
72TCF7_22412390_ChIP-Seq_EML_Mouse1.23125574
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21746561
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.20810653
75VDR_24763502_ChIP-Seq_THP-1_Human1.19507864
76TFEB_21752829_ChIP-Seq_HELA_Human1.19342819
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19112853
78* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18229888
79* CIITA_25753668_ChIP-Seq_RAJI_Human1.18075819
80* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17245101
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15447366
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15361119
83VDR_23849224_ChIP-Seq_CD4+_Human1.14320529
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14213850
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13695980
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13056591
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12088548
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11796367
89* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09864174
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09454263
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09116827
92* EST1_17652178_ChIP-ChIP_JURKAT_Human1.07791810
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07296799
94KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06115743
95KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06115743
96KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06115743
97* ETS1_20019798_ChIP-Seq_JURKAT_Human1.06097905
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05630294
99* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05299445
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04600933
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04586679
102KDM2B_26808549_Chip-Seq_DND41_Human1.04413334
103SPI1_23127762_ChIP-Seq_K562_Human1.03808595
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03240369
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02889531
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02123251
107GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01880664
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99833085
109ZNF263_19887448_ChIP-Seq_K562_Human0.98947099
110NOTCH1_21737748_ChIP-Seq_TLL_Human0.98789347
111JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98596973
112GABP_17652178_ChIP-ChIP_JURKAT_Human0.97762226
113CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97702694
114E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97470756
115* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96238115
116KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95968450
117LXR_22292898_ChIP-Seq_THP-1_Human0.95955019
118* FOXP3_21729870_ChIP-Seq_TREG_Human0.95762444
119ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95614935
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94893253
121MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94671096
122* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94345247
123NCOR1_26117541_ChIP-Seq_K562_Human0.94248985
124KDM5A_27292631_Chip-Seq_BREAST_Human0.93350593
125* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92910222
126* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92389275
127SCL_19346495_ChIP-Seq_HPC-7_Human0.92376322
128ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91845592
129GABP_19822575_ChIP-Seq_HepG2_Human0.91726199
130PU_27001747_Chip-Seq_BMDM_Mouse0.91628704
131GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90924767
132RUNX_20019798_ChIP-Seq_JUKART_Human0.89853598
133CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89623951
134DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89483342
135TP63_19390658_ChIP-ChIP_HaCaT_Human0.88483597

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.68920700
2MP0002877_abnormal_melanocyte_morpholog3.03165434
3MP0009785_altered_susceptibility_to3.02335809
4MP0000685_abnormal_immune_system2.95427797
5MP0003436_decreased_susceptibility_to2.83048486
6MP0001800_abnormal_humoral_immune2.58115964
7MP0001790_abnormal_immune_system2.56326632
8MP0005387_immune_system_phenotype2.56326632
9MP0003303_peritoneal_inflammation2.51663693
10MP0006082_CNS_inflammation2.51135630
11MP0005000_abnormal_immune_tolerance2.48939805
12MP0005025_abnormal_response_to2.47141003
13MP0003806_abnormal_nucleotide_metabolis2.42203969
14MP0002452_abnormal_antigen_presenting2.36642662
15MP0008057_abnormal_DNA_replication2.34285684
16MP0005671_abnormal_response_to2.33797969
17MP0002148_abnormal_hypersensitivity_rea2.29562002
18MP0002723_abnormal_immune_serum2.28379581
19MP0003724_increased_susceptibility_to2.20644619
20MP0003763_abnormal_thymus_physiology2.18690888
21MP0010352_gastrointestinal_tract_polyps2.14343146
22MP0010307_abnormal_tumor_latency2.13382495
23MP0003693_abnormal_embryo_hatching2.12796980
24MP0008260_abnormal_autophagy2.12780695
25MP0001819_abnormal_immune_cell2.12062171
26MP0002420_abnormal_adaptive_immunity2.09772957
27MP0002419_abnormal_innate_immunity2.08945385
28MP0002398_abnormal_bone_marrow2.04810419
29MP0009278_abnormal_bone_marrow2.03713720
30MP0009333_abnormal_splenocyte_physiolog2.00052181
31MP0002396_abnormal_hematopoietic_system1.88596112
32MP0010094_abnormal_chromosome_stability1.84747444
33MP0001545_abnormal_hematopoietic_system1.84491096
34MP0005397_hematopoietic_system_phenotyp1.84491096
35MP0003786_premature_aging1.82664859
36MP0000716_abnormal_immune_system1.81646257
37MP0005451_abnormal_body_composition1.81584489
38MP0003077_abnormal_cell_cycle1.81504663
39MP0005076_abnormal_cell_differentiation1.80131699
40MP0004947_skin_inflammation1.77226716
41MP0002405_respiratory_system_inflammati1.76965112
42MP0000858_altered_metastatic_potential1.74442976
43* MP0003111_abnormal_nucleus_morphology1.67734747
44MP0000689_abnormal_spleen_morphology1.65696940
45MP0002722_abnormal_immune_system1.65581191
46MP0003448_altered_tumor_morphology1.65544707
47MP0004510_myositis1.62971801
48MP0004957_abnormal_blastocyst_morpholog1.62046041
49MP0010155_abnormal_intestine_physiology1.61090187
50MP0002429_abnormal_blood_cell1.61012573
51MP0002006_tumorigenesis1.60224828
52MP0001533_abnormal_skeleton_physiology1.58285123
53MP0002166_altered_tumor_susceptibility1.51214910
54MP0004808_abnormal_hematopoietic_stem1.48554276
55MP0001845_abnormal_inflammatory_respons1.48173512
56MP0000703_abnormal_thymus_morphology1.46324946
57MP0001853_heart_inflammation1.41641186
58MP0008058_abnormal_DNA_repair1.39108482
59MP0003566_abnormal_cell_adhesion1.36171427
60MP0005464_abnormal_platelet_physiology1.35279758
61MP0008007_abnormal_cellular_replicative1.29390716
62MP0005501_abnormal_skin_physiology1.26198813
63MP0009764_decreased_sensitivity_to1.25641189
64MP0008469_abnormal_protein_level1.23753070
65MP0002019_abnormal_tumor_incidence1.23021627
66MP0005023_abnormal_wound_healing1.21596091
67MP0000490_abnormal_crypts_of1.20989220
68MP0002796_impaired_skin_barrier1.20297945
69MP0000350_abnormal_cell_proliferation1.17935070
70MP0006035_abnormal_mitochondrial_morpho1.17926820
71MP0003172_abnormal_lysosome_physiology1.17027174
72MP0001849_ear_inflammation1.12417455
73MP0009672_abnormal_birth_weight1.11564364
74MP0003191_abnormal_cellular_cholesterol1.08975207
75MP0003705_abnormal_hypodermis_morpholog1.05610674
76MP0001730_embryonic_growth_arrest1.02895587
77MP0000343_altered_response_to1.01898617
78MP0000358_abnormal_cell_content/1.00778910
79MP0002254_reproductive_system_inflammat0.99586741
80MP0009840_abnormal_foam_cell0.99483451
81MP0005058_abnormal_lysosome_morphology0.99009469
82MP0002132_abnormal_respiratory_system0.96812567
83* MP0000313_abnormal_cell_death0.96741455
84MP0003300_gastrointestinal_ulcer0.94786324
85MP0006036_abnormal_mitochondrial_physio0.93872105
86MP0005384_cellular_phenotype0.91298278
87MP0001915_intracranial_hemorrhage0.90769924
88MP0003075_altered_response_to0.90586463
89MP0000678_abnormal_parathyroid_gland0.89701412
90MP0005310_abnormal_salivary_gland0.88821579
91MP0003315_abnormal_perineum_morphology0.85724471
92MP0004185_abnormal_adipocyte_glucose0.85588269
93MP0005390_skeleton_phenotype0.85302508
94MP0003453_abnormal_keratinocyte_physiol0.84466523
95MP0001727_abnormal_embryo_implantation0.83495429
96MP0003941_abnormal_skin_development0.82933466
97* MP0002086_abnormal_extraembryonic_tissu0.82453607
98MP0003718_maternal_effect0.81652462
99MP0001873_stomach_inflammation0.80927778
100MP0005670_abnormal_white_adipose0.76393854
101MP0006054_spinal_hemorrhage0.76143065
102* MP0002085_abnormal_embryonic_tissue0.74863275
103* MP0001697_abnormal_embryo_size0.74600204
104MP0002998_abnormal_bone_remodeling0.74338060
105MP0003186_abnormal_redox_activity0.73019049
106MP0000371_diluted_coat_color0.71927701
107* MP0002080_prenatal_lethality0.71436808
108MP0003221_abnormal_cardiomyocyte_apopto0.70666280
109MP0005621_abnormal_cell_physiology0.70431726
110* MP0001672_abnormal_embryogenesis/_devel0.70382709
111* MP0005380_embryogenesis_phenotype0.70382709
112* MP0003984_embryonic_growth_retardation0.69934280
113MP0002933_joint_inflammation0.69630770
114MP0009763_increased_sensitivity_to0.68962707
115* MP0002088_abnormal_embryonic_growth/wei0.68743525
116MP0008932_abnormal_embryonic_tissue0.67128404
117MP0004197_abnormal_fetal_growth/weight/0.65566786
118MP0008438_abnormal_cutaneous_collagen0.64685587
119MP0003091_abnormal_cell_migration0.64561724
120MP0005174_abnormal_tail_pigmentation0.62688446
121MP0003866_abnormal_defecation0.62288218
122MP0001293_anophthalmia0.61707900
123MP0008877_abnormal_DNA_methylation0.59216785

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.70153309
2Nasal polyposis (HP:0100582)4.58172749
3Elevated erythrocyte sedimentation rate (HP:0003565)4.50361546
4Recurrent abscess formation (HP:0002722)4.34118001
5Mediastinal lymphadenopathy (HP:0100721)4.02631219
6Chronic otitis media (HP:0000389)3.99348075
7Abnormality of the nasal mucosa (HP:0000433)3.96522125
8Recurrent bacterial skin infections (HP:0005406)3.96491480
9Autoimmune thrombocytopenia (HP:0001973)3.88727185
10Recurrent bronchitis (HP:0002837)3.78480202
11Recurrent viral infections (HP:0004429)3.70210200
12Aplastic anemia (HP:0001915)3.55840977
13Myositis (HP:0100614)3.51649439
14Increased IgM level (HP:0003496)3.45686088
15Microvesicular hepatic steatosis (HP:0001414)3.41300295
16Recurrent fungal infections (HP:0002841)3.32982581
17Abnormality of macrophages (HP:0004311)3.31568884
18Cholecystitis (HP:0001082)3.19636123
19Abnormal gallbladder physiology (HP:0012438)3.19636123
20Rough bone trabeculation (HP:0100670)3.06046014
21Recurrent gram-negative bacterial infections (HP:0005420)2.98860140
22Orchitis (HP:0100796)2.97301867
23Basal ganglia calcification (HP:0002135)2.86628046
24Porencephaly (HP:0002132)2.85996235
25Vasculitis (HP:0002633)2.85575319
26Abnormality of T cells (HP:0002843)2.84418590
27Pustule (HP:0200039)2.82332659
28Abnormality of T cell number (HP:0011839)2.80405336
29Multiple enchondromatosis (HP:0005701)2.79076141
30Ragged-red muscle fibers (HP:0003200)2.74723160
31T lymphocytopenia (HP:0005403)2.72843767
32Cleft eyelid (HP:0000625)2.72760152
33Progressive muscle weakness (HP:0003323)2.70611205
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.66819677
35Emphysema (HP:0002097)2.63930727
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62329673
37Cellulitis (HP:0100658)2.61583901
38Agnosia (HP:0010524)2.60441600
39Hypertensive crisis (HP:0100735)2.60416530
40Abnormality of T cell physiology (HP:0011840)2.55847410
41Stomatitis (HP:0010280)2.55641542
42Hypergammaglobulinemia (HP:0010702)2.53903336
43Recurrent skin infections (HP:0001581)2.49619590
44Abnormal umbilical cord blood vessels (HP:0011403)2.44146527
45Single umbilical artery (HP:0001195)2.44146527
46Abnormality of the fetal cardiovascular system (HP:0010948)2.44146527
47Abnormality of the anterior horn cell (HP:0006802)2.43781138
48Degeneration of anterior horn cells (HP:0002398)2.43781138
49Abnormality of the umbilical cord (HP:0010881)2.43179866
50Abnormality of cells of the lymphoid lineage (HP:0012140)2.40413782
51Trismus (HP:0000211)2.40204145
52Retrobulbar optic neuritis (HP:0100654)2.39098609
53Optic neuritis (HP:0100653)2.39098609
54Gingivitis (HP:0000230)2.39097777
55Bronchitis (HP:0012387)2.37829311
56Pulmonary infiltrates (HP:0002113)2.36821157
57Interstitial pulmonary disease (HP:0006530)2.34832372
58Increased serum ferritin (HP:0003281)2.33005243
59Abnormal trabecular bone morphology (HP:0100671)2.30524114
60Recurrent cutaneous fungal infections (HP:0011370)2.30499347
61Chronic mucocutaneous candidiasis (HP:0002728)2.30499347
62Combined immunodeficiency (HP:0005387)2.28664394
63Progressive external ophthalmoplegia (HP:0000590)2.27339076
64Pancytopenia (HP:0001876)2.26951915
65Autoimmune hemolytic anemia (HP:0001890)2.26865025
66Leukocytosis (HP:0001974)2.26819101
67Selective tooth agenesis (HP:0001592)2.24896140
68Entropion (HP:0000621)2.24471227
69Hepatosplenomegaly (HP:0001433)2.23551599
70Lymphopenia (HP:0001888)2.23545897
71Chronic obstructive pulmonary disease (HP:0006510)2.20532042
72Obstructive lung disease (HP:0006536)2.20532042
73Oral leukoplakia (HP:0002745)2.18750931
74Chromsome breakage (HP:0040012)2.17326669
75Lymphoma (HP:0002665)2.17211270
76IgA deficiency (HP:0002720)2.14482319
77Aplasia/Hypoplasia of the thymus (HP:0010515)2.14400704
78Chronic sinusitis (HP:0011109)2.13147048
79Thrombocytosis (HP:0001894)2.13079197
80Premature ovarian failure (HP:0008209)2.11159236
81Squamous cell carcinoma (HP:0002860)2.10126927
82IgM deficiency (HP:0002850)2.09130902
83Seborrheic dermatitis (HP:0001051)2.09107324
84Vertebral compression fractures (HP:0002953)2.08769945
85Eosinophilia (HP:0001880)2.07769596
86Poor head control (HP:0002421)2.05971020
87Agammaglobulinemia (HP:0004432)2.05729355
88Petechiae (HP:0000967)2.01161674
89Recurrent lower respiratory tract infections (HP:0002783)2.01100726
90Meningitis (HP:0001287)2.01063000
91Abnormal delayed hypersensitivity skin test (HP:0002963)2.00409723
92IgG deficiency (HP:0004315)2.00090877
93Tetraparesis (HP:0002273)1.98766325
94Abnormality of the preputium (HP:0100587)1.98293556
95Abnormality of the fingertips (HP:0001211)1.98047076
96Abnormality of glycolysis (HP:0004366)1.97501720
97Fatigue (HP:0012378)1.97230665
98Nonimmune hydrops fetalis (HP:0001790)1.95905702
99Ependymoma (HP:0002888)1.94289883
100Type I transferrin isoform profile (HP:0003642)1.93137284
101Amaurosis fugax (HP:0100576)1.92628102
102Myelodysplasia (HP:0002863)1.92206518
103Systemic lupus erythematosus (HP:0002725)1.92093298
104Osteomyelitis (HP:0002754)1.91694870
105Disinhibition (HP:0000734)1.91042254
106Abnormal number of incisors (HP:0011064)1.90035144
107Skin ulcer (HP:0200042)1.89264339
108Bone marrow hypocellularity (HP:0005528)1.88825149
109Granulocytopenia (HP:0001913)1.88774192
110Increased serum pyruvate (HP:0003542)1.88671815
111Increased IgE level (HP:0003212)1.87527586
112Reticulocytopenia (HP:0001896)1.86476084
113Urticaria (HP:0001025)1.86053755
114Gastrointestinal inflammation (HP:0004386)1.85264095
115Colitis (HP:0002583)1.85144815
116Centrally nucleated skeletal muscle fibers (HP:0003687)1.84976143
117Periodontitis (HP:0000704)1.84839170
118Premature graying of hair (HP:0002216)1.84555871
119Spinal muscular atrophy (HP:0007269)1.83710051
120Abnormality of the pleura (HP:0002103)1.83619460
121Abnormality of eosinophils (HP:0001879)1.81799026
122Prostate neoplasm (HP:0100787)1.78062207
123Birth length less than 3rd percentile (HP:0003561)1.77618233
124Panhypogammaglobulinemia (HP:0003139)1.77580435
125Gastrointestinal stroma tumor (HP:0100723)1.76877622
126Inflammation of the large intestine (HP:0002037)1.76657988
127Hemoptysis (HP:0002105)1.76538230
128Increased cerebral lipofuscin (HP:0011813)1.76217216
129Spontaneous hematomas (HP:0007420)1.75813011
130Recurrent pneumonia (HP:0006532)1.75702110
131Neoplasm of head and neck (HP:0012288)1.75574548
132Esophageal neoplasm (HP:0100751)1.75574548
133Reduced antithrombin III activity (HP:0001976)1.74227586
134Orthostatic hypotension (HP:0001278)1.74136701
135Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.73512186
136Impaired platelet aggregation (HP:0003540)1.72601830
137Abnormal platelet function (HP:0011869)1.72601830
138Severe combined immunodeficiency (HP:0004430)1.71601675
139Secondary amenorrhea (HP:0000869)1.71360786
140Leukopenia (HP:0001882)1.70854942
141Sparse eyelashes (HP:0000653)1.70605299
142Decreased activity of mitochondrial respiratory chain (HP:0008972)1.70158973
143Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.70158973
144Anorexia (HP:0002039)1.69704990
145High pitched voice (HP:0001620)1.68299820
146Basal cell carcinoma (HP:0002671)1.68161992
147Albinism (HP:0001022)1.67935519
148Chest pain (HP:0100749)1.66863280
149Abnormalities of placenta or umbilical cord (HP:0001194)1.66857949
150Poikiloderma (HP:0001029)1.66498224
151Cholelithiasis (HP:0001081)1.66391462
152Plagiocephaly (HP:0001357)1.66317176
153Encephalitis (HP:0002383)1.65866197
154Breast hypoplasia (HP:0003187)1.65387056
155Progressive neurologic deterioration (HP:0002344)1.63179191
156Abnormal number of erythroid precursors (HP:0012131)1.62767601
157Gastrointestinal dysmotility (HP:0002579)1.62426347
158Acute hepatic failure (HP:0006554)1.62134943
159Hypopigmented skin patches (HP:0001053)1.60994343
160Cellular immunodeficiency (HP:0005374)1.60966471

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.69660682
2MAP4K13.47042082
3TYK23.24470455
4SMG13.14583170
5ERN12.97393805
6JAK32.72084427
7TBK12.63300268
8STK102.61035717
9BLK2.57424497
10MAP3K102.44844541
11IKBKE2.41527152
12PIM22.41385875
13CDK122.30423770
14SRPK12.26446878
15MAP3K142.19138287
16TXK2.02442495
17TAF11.98909931
18ZAP701.97305270
19FGFR41.86275398
20IKBKB1.84913941
21JAK11.84325001
22IRAK41.81080271
23PRPF4B1.72309412
24CSK1.70292111
25RPS6KA41.67910601
26CDC71.67597710
27TSSK61.65797489
28KIT1.62163335
29PBK1.53261885
30FLT31.50348977
31TAOK21.46728233
32NEK21.46465264
33TRIB31.44302337
34PIM11.43582201
35NEK11.30443819
36CHUK1.30056614
37STK161.24051286
38EEF2K1.19675243
39NME21.18010571
40TESK21.16755289
41CLK11.16203503
42GRK61.15632621
43STK41.09010901
44LRRK21.08665303
45TESK11.07130154
46FGFR31.06576562
47MAP3K131.05902965
48DAPK11.04415567
49CDK41.03917485
50PKN21.02752116
51PLK31.00886999
52CDK70.97530802
53SYK0.97507180
54SIK30.96105699
55BTK0.95808235
56LCK0.95672621
57MAP3K80.95631900
58WEE10.95308353
59MAP3K110.93194841
60BRSK10.93097074
61* ATR0.92332885
62AURKA0.91209415
63VRK10.91153080
64CHEK20.90377852
65MATK0.90362657
66RIPK40.89710574
67CSF1R0.89482616
68BUB10.88823734
69PAK40.86871967
70ARAF0.86288295
71EIF2AK10.86158110
72ALK0.85027456
73BMPR20.83546009
74HCK0.83330016
75SCYL20.81917597
76MARK30.79706134
77MAP3K30.78789467
78IRAK30.78745175
79ICK0.75179178
80ZAK0.75057464
81PRKCI0.74200784
82LYN0.74116425
83EPHB10.72753623
84ITK0.72236182
85NME10.72187860
86PLK40.70729367
87KDR0.68036411
88RPS6KB20.67833150
89STK30.67784547
90PASK0.66988083
91JAK20.66820001
92EPHA30.65529830
93BMX0.63824830
94RIPK10.62966978
95RAF10.62601748
96BCKDK0.61997231
97NLK0.61893535
98SIK10.61568164
99MST40.59474280
100CDK90.58788477
101PLK10.57329320
102LIMK10.57119909
103PDGFRA0.56987931
104BRAF0.56027054
105DYRK30.55487310
106EIF2AK30.54295210
107TLK10.53617027
108CDK60.53616329
109NEK90.53418825
110EPHA20.53283712
111CHEK10.51624633
112MAPK110.51225621
113MTOR0.50008121
114CCNB10.49271614
115PTK60.48176483
116TTK0.47739976
117MAP2K30.46351700
118TAOK10.46015903
119PAK10.44642467
120FGR0.44545572
121IRAK10.44049577
122TRPM70.43613156
123RPS6KA10.42684536
124AURKB0.41019523
125MAPKAPK20.40879287
126TGFBR10.40161588
127TGFBR20.39425691
128CSNK2A20.38969917
129EGFR0.37882061
130EIF2AK20.37528104
131TEC0.36933108
132MELK0.36923072
133* ATM0.36878551
134KSR20.35931205
135RPS6KA50.35638257
136* CDK20.35446842
137RPS6KA60.34438393

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.73361723
2DNA replication_Homo sapiens_hsa030302.38547439
3Measles_Homo sapiens_hsa051622.36747150
4Leishmaniasis_Homo sapiens_hsa051402.32876493
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.28434657
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.27230459
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.26487634
8* Herpes simplex infection_Homo sapiens_hsa051682.20913717
9Antigen processing and presentation_Homo sapiens_hsa046122.10490468
10Primary immunodeficiency_Homo sapiens_hsa053402.08997653
11Legionellosis_Homo sapiens_hsa051342.06388448
12Influenza A_Homo sapiens_hsa051642.00795140
13Graft-versus-host disease_Homo sapiens_hsa053321.94331106
14Base excision repair_Homo sapiens_hsa034101.83115348
15Allograft rejection_Homo sapiens_hsa053301.79331489
16Mismatch repair_Homo sapiens_hsa034301.76298798
17Osteoclast differentiation_Homo sapiens_hsa043801.66868481
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.65861301
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61894583
20TNF signaling pathway_Homo sapiens_hsa046681.61467557
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.61200069
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58481710
23One carbon pool by folate_Homo sapiens_hsa006701.54123690
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53282915
25Biosynthesis of amino acids_Homo sapiens_hsa012301.50692758
26Toxoplasmosis_Homo sapiens_hsa051451.45506873
27* Apoptosis_Homo sapiens_hsa042101.40405660
28B cell receptor signaling pathway_Homo sapiens_hsa046621.40389519
29Spliceosome_Homo sapiens_hsa030401.40017782
30RNA transport_Homo sapiens_hsa030131.38663890
31Hepatitis B_Homo sapiens_hsa051611.38566016
32Viral myocarditis_Homo sapiens_hsa054161.37941674
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32798010
34Proteasome_Homo sapiens_hsa030501.30912527
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.29442880
36Tuberculosis_Homo sapiens_hsa051521.29102385
37Shigellosis_Homo sapiens_hsa051311.28686250
38Pertussis_Homo sapiens_hsa051331.27064989
39Malaria_Homo sapiens_hsa051441.26831902
40Epstein-Barr virus infection_Homo sapiens_hsa051691.25532183
41Staphylococcus aureus infection_Homo sapiens_hsa051501.24790758
42T cell receptor signaling pathway_Homo sapiens_hsa046601.22045382
43p53 signaling pathway_Homo sapiens_hsa041151.21283951
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20894002
45Cell cycle_Homo sapiens_hsa041101.19920870
46Viral carcinogenesis_Homo sapiens_hsa052031.19619858
47Acute myeloid leukemia_Homo sapiens_hsa052211.18418058
48Homologous recombination_Homo sapiens_hsa034401.15738508
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14983944
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14639301
51Hepatitis C_Homo sapiens_hsa051601.09966485
52Type I diabetes mellitus_Homo sapiens_hsa049401.09006326
53Carbon metabolism_Homo sapiens_hsa012001.08839618
54Asthma_Homo sapiens_hsa053101.07088703
55Notch signaling pathway_Homo sapiens_hsa043301.06966709
56Salmonella infection_Homo sapiens_hsa051321.06681705
57Chronic myeloid leukemia_Homo sapiens_hsa052201.03328573
58Hematopoietic cell lineage_Homo sapiens_hsa046401.00710545
59Fructose and mannose metabolism_Homo sapiens_hsa000510.98244150
60Galactose metabolism_Homo sapiens_hsa000520.96852295
61Chemokine signaling pathway_Homo sapiens_hsa040620.95336013
62HTLV-I infection_Homo sapiens_hsa051660.91980546
63Small cell lung cancer_Homo sapiens_hsa052220.91503816
64Bladder cancer_Homo sapiens_hsa052190.90947790
65Pyrimidine metabolism_Homo sapiens_hsa002400.90751757
66N-Glycan biosynthesis_Homo sapiens_hsa005100.90492195
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89721669
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88727435
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88166993
70RNA polymerase_Homo sapiens_hsa030200.87786061
71Nucleotide excision repair_Homo sapiens_hsa034200.87687900
72African trypanosomiasis_Homo sapiens_hsa051430.87149760
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85757929
74Fatty acid elongation_Homo sapiens_hsa000620.83730936
75Pancreatic cancer_Homo sapiens_hsa052120.83728395
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83100179
77Purine metabolism_Homo sapiens_hsa002300.81182426
78Sulfur relay system_Homo sapiens_hsa041220.80295320
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77318319
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.77053756
81Ribosome_Homo sapiens_hsa030100.75239837
82MicroRNAs in cancer_Homo sapiens_hsa052060.74499820
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71520930
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71355190
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70789125
86Autoimmune thyroid disease_Homo sapiens_hsa053200.69760071
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.69340400
88Prolactin signaling pathway_Homo sapiens_hsa049170.69308570
89Fanconi anemia pathway_Homo sapiens_hsa034600.68880868
90Non-homologous end-joining_Homo sapiens_hsa034500.68427523
91mRNA surveillance pathway_Homo sapiens_hsa030150.66557855
92Folate biosynthesis_Homo sapiens_hsa007900.66316421
93RNA degradation_Homo sapiens_hsa030180.65747469
94HIF-1 signaling pathway_Homo sapiens_hsa040660.65073898
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.64856981
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64825222
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.64525393
98Rheumatoid arthritis_Homo sapiens_hsa053230.63245100
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61200040
100Colorectal cancer_Homo sapiens_hsa052100.58485197
101Pyruvate metabolism_Homo sapiens_hsa006200.55193177
102Glutathione metabolism_Homo sapiens_hsa004800.54095078
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53446031
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51779853
105Thyroid cancer_Homo sapiens_hsa052160.50735428
106Lysosome_Homo sapiens_hsa041420.50699452
107mTOR signaling pathway_Homo sapiens_hsa041500.50072639
108Systemic lupus erythematosus_Homo sapiens_hsa053220.49998979
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.47997137
110Pentose phosphate pathway_Homo sapiens_hsa000300.45991452
111VEGF signaling pathway_Homo sapiens_hsa043700.45839623
112Basal transcription factors_Homo sapiens_hsa030220.45617023
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43404045
114Parkinsons disease_Homo sapiens_hsa050120.41610242
115Amoebiasis_Homo sapiens_hsa051460.40207946
116Adherens junction_Homo sapiens_hsa045200.39396758
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38830086
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38153553
119Non-small cell lung cancer_Homo sapiens_hsa052230.37087563
120Phagosome_Homo sapiens_hsa041450.36956653
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.36108195
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35845343
123Other glycan degradation_Homo sapiens_hsa005110.35160520
124Proteoglycans in cancer_Homo sapiens_hsa052050.34970739
125TGF-beta signaling pathway_Homo sapiens_hsa043500.34676809
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.33540362
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.33194861
128Huntingtons disease_Homo sapiens_hsa050160.32761433
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31880291

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