DARS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a multienzyme complex that functions in mediating the attachment of amino acids to their cognate tRNAs. The encoded protein ligates L-aspartate to tRNA(Asp). Mutations in this gene have been found in patients showing hypomyelination with brainstem and spinal cord involvement and leg spasticity. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.21678209
2DNA strand elongation involved in DNA replication (GO:0006271)4.76593883
3IMP biosynthetic process (GO:0006188)4.71872169
4DNA replication initiation (GO:0006270)4.70969211
5DNA strand elongation (GO:0022616)4.51241010
6IMP metabolic process (GO:0046040)4.43352271
7formation of translation preinitiation complex (GO:0001731)4.42330366
8folic acid-containing compound biosynthetic process (GO:0009396)4.35315704
9telomere maintenance via semi-conservative replication (GO:0032201)4.32193052
10nucleobase biosynthetic process (GO:0046112)4.30557794
11ribosomal small subunit assembly (GO:0000028)4.30200093
12purine nucleobase biosynthetic process (GO:0009113)4.10928485
13DNA ligation (GO:0006266)4.06463404
14protein localization to kinetochore (GO:0034501)4.03206466
15maturation of SSU-rRNA (GO:0030490)3.99606789
16telomere maintenance via recombination (GO:0000722)3.82305310
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.73565194
18DNA replication-dependent nucleosome assembly (GO:0006335)3.73337034
19DNA replication-dependent nucleosome organization (GO:0034723)3.73337034
20DNA replication checkpoint (GO:0000076)3.70598734
21ribosome assembly (GO:0042255)3.68115011
22mitotic recombination (GO:0006312)3.66154590
23mitotic nuclear envelope disassembly (GO:0007077)3.63558891
24establishment of protein localization to mitochondrial membrane (GO:0090151)3.58832858
25DNA deamination (GO:0045006)3.58230538
26mitotic metaphase plate congression (GO:0007080)3.58195234
27establishment of viral latency (GO:0019043)3.57927410
28translational termination (GO:0006415)3.55808918
29viral transcription (GO:0019083)3.54295524
30nuclear pore organization (GO:0006999)3.50940706
31chromatin remodeling at centromere (GO:0031055)3.50773676
32CENP-A containing nucleosome assembly (GO:0034080)3.49487347
33telomere maintenance via telomere lengthening (GO:0010833)3.44110078
34protein localization to chromosome, centromeric region (GO:0071459)3.40604842
35translational elongation (GO:0006414)3.40580063
36ribosome biogenesis (GO:0042254)3.35339216
37nuclear envelope disassembly (GO:0051081)3.33550282
38membrane disassembly (GO:0030397)3.33550282
39nucleotide-excision repair, DNA gap filling (GO:0006297)3.33317020
40regulation of mitochondrial translation (GO:0070129)3.32605289
41ribosomal large subunit biogenesis (GO:0042273)3.32340273
42oxidative phosphorylation (GO:0006119)3.31688146
43translational initiation (GO:0006413)3.29628357
44ribonucleoprotein complex biogenesis (GO:0022613)3.27973335
45establishment of integrated proviral latency (GO:0075713)3.27503446
46DNA replication-independent nucleosome organization (GO:0034724)3.24056487
47DNA replication-independent nucleosome assembly (GO:0006336)3.24056487
48metaphase plate congression (GO:0051310)3.23886258
49DNA duplex unwinding (GO:0032508)3.23301166
50nuclear pore complex assembly (GO:0051292)3.21367200
51ribosomal small subunit biogenesis (GO:0042274)3.21233320
52DNA geometric change (GO:0032392)3.20885663
53* translation (GO:0006412)3.20151200
54chaperone-mediated protein transport (GO:0072321)3.20065269
55cullin deneddylation (GO:0010388)3.20054734
56pteridine-containing compound biosynthetic process (GO:0042559)3.19886566
57SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.15480397
58ATP synthesis coupled proton transport (GO:0015986)3.15195171
59energy coupled proton transport, down electrochemical gradient (GO:0015985)3.15195171
60regulation of spindle organization (GO:0090224)3.14795525
61somatic hypermutation of immunoglobulin genes (GO:0016446)3.13701598
62somatic diversification of immune receptors via somatic mutation (GO:0002566)3.13701598
63attachment of spindle microtubules to kinetochore (GO:0008608)3.11902941
64DNA damage response, detection of DNA damage (GO:0042769)3.10353392
65L-serine metabolic process (GO:0006563)3.09433782
66folic acid metabolic process (GO:0046655)3.08260177
67cotranslational protein targeting to membrane (GO:0006613)3.08111739
68postreplication repair (GO:0006301)3.07235879
69mitotic chromosome condensation (GO:0007076)3.07153362
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.06838754
71rRNA processing (GO:0006364)3.06718133
72DNA strand renaturation (GO:0000733)3.06523312
73protein targeting to ER (GO:0045047)3.06001633
74non-recombinational repair (GO:0000726)3.05105570
75double-strand break repair via nonhomologous end joining (GO:0006303)3.05105570
76regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03521431
77translesion synthesis (GO:0019985)3.03068293
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01724127
79exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.96982264
80protein deneddylation (GO:0000338)2.96946488
81establishment of chromosome localization (GO:0051303)2.95037518
82rRNA metabolic process (GO:0016072)2.95005047
83regulation of helicase activity (GO:0051095)2.94750055
84negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.92677130
85protein localization to endoplasmic reticulum (GO:0070972)2.92330536
86negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92139288
87negative regulation of ligase activity (GO:0051352)2.92139288
88histone exchange (GO:0043486)2.91546120
89establishment of protein localization to endoplasmic reticulum (GO:0072599)2.90838503
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90739610
91proteasome assembly (GO:0043248)2.90555700
92* tRNA aminoacylation (GO:0043039)2.89822315
93* amino acid activation (GO:0043038)2.89822315
94nuclear-transcribed mRNA catabolic process (GO:0000956)2.89416900
95spliceosomal snRNP assembly (GO:0000387)2.89013508
96pseudouridine synthesis (GO:0001522)2.88882507
97kinetochore assembly (GO:0051382)2.87179514
98DNA topological change (GO:0006265)2.86838562
99tetrahydrofolate metabolic process (GO:0046653)2.86483668
100G1/S transition of mitotic cell cycle (GO:0000082)2.86004171
101cell cycle G1/S phase transition (GO:0044843)2.86004171
102regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.85534297
103regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.84026872
104positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83289177
105negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.82885962
106negative regulation of sister chromatid segregation (GO:0033046)2.82885962
107negative regulation of mitotic sister chromatid separation (GO:2000816)2.82885962
108negative regulation of mitotic sister chromatid segregation (GO:0033048)2.82885962
109negative regulation of chromosome segregation (GO:0051985)2.82616710
110spindle assembly checkpoint (GO:0071173)2.82208864
111serine family amino acid biosynthetic process (GO:0009070)2.82044478
112mitotic spindle assembly checkpoint (GO:0007094)2.80788213
113protein complex disassembly (GO:0043241)2.79512761
114telomere organization (GO:0032200)2.79318839
115telomere maintenance (GO:0000723)2.78788186
116cellular component biogenesis (GO:0044085)2.77731575
117cellular protein complex disassembly (GO:0043624)2.77730264
118pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.77496344
119somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.77332180
120somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.77332180
121isotype switching (GO:0045190)2.77332180
122kinetochore organization (GO:0051383)2.77120595
123* tRNA aminoacylation for protein translation (GO:0006418)2.76039617
124DNA catabolic process, exonucleolytic (GO:0000738)2.75974294
125macromolecular complex disassembly (GO:0032984)2.75566939
126spindle checkpoint (GO:0031577)2.74025653
127base-excision repair (GO:0006284)2.73489048
128replication fork processing (GO:0031297)2.73277538
129mRNA catabolic process (GO:0006402)2.73248007
130negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.72923516
131viral life cycle (GO:0019058)2.72331460
132mitotic sister chromatid segregation (GO:0000070)2.72233248
133regulation of sister chromatid cohesion (GO:0007063)2.71806330
134pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.70369768
135regulation of translational fidelity (GO:0006450)2.69541963
136transcription-coupled nucleotide-excision repair (GO:0006283)2.68946217
137mitotic spindle checkpoint (GO:0071174)2.67806317
138sister chromatid segregation (GO:0000819)2.67534647
139mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.65621128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.22543831
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.24987516
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.91943428
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36403400
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.31512790
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.89223991
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.79208853
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.78610003
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74148466
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73500880
11* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.70178547
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.69556506
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.57817488
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57517454
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.50263604
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37356790
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29642767
18VDR_23849224_ChIP-Seq_CD4+_Human2.24794049
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24192605
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.23683300
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.23279171
22AR_21909140_ChIP-Seq_LNCAP_Human2.20591084
23XRN2_22483619_ChIP-Seq_HELA_Human2.20262583
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03465722
25FOXP3_21729870_ChIP-Seq_TREG_Human2.00724290
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95948646
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91947179
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.91706781
29* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89619451
30DCP1A_22483619_ChIP-Seq_HELA_Human1.89265492
31* E2F1_21310950_ChIP-Seq_MCF-7_Human1.86485069
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84710249
33GABP_19822575_ChIP-Seq_HepG2_Human1.81514842
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80969271
35* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77377154
36* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.75711271
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68852424
38* ELK1_19687146_ChIP-ChIP_HELA_Human1.65318536
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.64902333
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63584828
41* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63321117
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63102489
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.62114130
44TTF2_22483619_ChIP-Seq_HELA_Human1.61553179
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61533875
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61291358
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60589495
48MYC_22102868_ChIP-Seq_BL_Human1.52850570
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52671282
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51605993
51EWS_26573619_Chip-Seq_HEK293_Human1.49626109
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48293468
53CIITA_25753668_ChIP-Seq_RAJI_Human1.47041148
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45921142
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45490573
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43591291
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.41053240
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40471998
59IGF1R_20145208_ChIP-Seq_DFB_Human1.39872647
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39225644
61FUS_26573619_Chip-Seq_HEK293_Human1.37275783
62KDM5A_27292631_Chip-Seq_BREAST_Human1.36709253
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36227619
64IRF1_19129219_ChIP-ChIP_H3396_Human1.35645347
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32966423
66* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29460814
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26364235
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.24479835
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22970040
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22621208
71TFEB_21752829_ChIP-Seq_HELA_Human1.21568867
72ZNF274_21170338_ChIP-Seq_K562_Hela1.19166913
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.19102721
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18512557
75* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17660808
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.15337736
77* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13679164
78* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12450165
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11816072
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11312371
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10504073
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09802891
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09343601
84SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07596973
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05739471
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.04980241
87ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.04392475
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04297174
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03629732
90SOX17_20123909_ChIP-Seq_XEN_Mouse1.02433940
91ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01411381
92SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99662273
93SPI1_23547873_ChIP-Seq_NB4_Human0.99115247
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97349738
95POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96272011
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95694037
97POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94963116
98TP63_19390658_ChIP-ChIP_HaCaT_Human0.94477896
99MYC_18940864_ChIP-ChIP_HL60_Human0.94026326
100NOTCH1_21737748_ChIP-Seq_TLL_Human0.93799649
101* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89127266
102VDR_21846776_ChIP-Seq_THP-1_Human0.87775024
103* HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86829138
104IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85943355
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85728561
106KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85574387
107* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84719874
108VDR_22108803_ChIP-Seq_LS180_Human0.84260000
109MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82444927
110CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82418711
111HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.81667343
112TAF15_26573619_Chip-Seq_HEK293_Human0.80834357
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80567826
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80281256
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80099569
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79747209
117PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79239419
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77319621
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.76734295
120NANOG_21062744_ChIP-ChIP_HESCs_Human0.76699732
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.75899575
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.75839169
123TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75621427
124ELK1_22589737_ChIP-Seq_MCF10A_Human0.75128250
125DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74229388

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.62112706
2MP0010094_abnormal_chromosome_stability4.37010944
3MP0004957_abnormal_blastocyst_morpholog4.26642295
4MP0003111_abnormal_nucleus_morphology3.77900778
5MP0003806_abnormal_nucleotide_metabolis3.65442505
6MP0008057_abnormal_DNA_replication3.62023483
7MP0003077_abnormal_cell_cycle3.59762417
8MP0006292_abnormal_olfactory_placode3.43153204
9MP0008058_abnormal_DNA_repair3.24859423
10MP0002396_abnormal_hematopoietic_system2.74366215
11MP0006072_abnormal_retinal_apoptosis2.51812338
12MP0009379_abnormal_foot_pigmentation2.51538269
13MP0001529_abnormal_vocalization2.50163637
14MP0008007_abnormal_cellular_replicative2.48157782
15MP0003136_yellow_coat_color2.28174097
16MP0001730_embryonic_growth_arrest2.24063587
17MP0010352_gastrointestinal_tract_polyps2.23329897
18MP0008932_abnormal_embryonic_tissue2.23157059
19MP0003122_maternal_imprinting2.14803834
20MP0008789_abnormal_olfactory_epithelium2.01728418
21MP0003123_paternal_imprinting1.96904499
22MP0010307_abnormal_tumor_latency1.93442968
23MP0000350_abnormal_cell_proliferation1.92876094
24MP0002938_white_spotting1.90339176
25MP0006054_spinal_hemorrhage1.83877010
26MP0005499_abnormal_olfactory_system1.69090446
27MP0005394_taste/olfaction_phenotype1.69090446
28MP0003186_abnormal_redox_activity1.68521574
29MP0003786_premature_aging1.67593579
30MP0008877_abnormal_DNA_methylation1.67215326
31MP0000490_abnormal_crypts_of1.62125732
32MP0004808_abnormal_hematopoietic_stem1.59134715
33MP0002019_abnormal_tumor_incidence1.50665660
34MP0001697_abnormal_embryo_size1.49483662
35MP0002080_prenatal_lethality1.49372384
36MP0003937_abnormal_limbs/digits/tail_de1.48977291
37MP0000647_abnormal_sebaceous_gland1.42030830
38MP0002233_abnormal_nose_morphology1.40991587
39MP0005380_embryogenesis_phenotype1.39991250
40MP0001672_abnormal_embryogenesis/_devel1.39991250
41MP0000372_irregular_coat_pigmentation1.37617862
42MP0005253_abnormal_eye_physiology1.37369370
43MP0000313_abnormal_cell_death1.37085699
44MP0003567_abnormal_fetal_cardiomyocyte1.34489701
45MP0003315_abnormal_perineum_morphology1.33536182
46MP0001545_abnormal_hematopoietic_system1.31460125
47MP0005397_hematopoietic_system_phenotyp1.31460125
48MP0008995_early_reproductive_senescence1.30891580
49MP0001286_abnormal_eye_development1.30090170
50MP0004197_abnormal_fetal_growth/weight/1.29817358
51MP0003763_abnormal_thymus_physiology1.28376049
52MP0002086_abnormal_extraembryonic_tissu1.27335548
53MP0003984_embryonic_growth_retardation1.27188985
54MP0003718_maternal_effect1.25118699
55MP0002088_abnormal_embryonic_growth/wei1.23704981
56MP0002084_abnormal_developmental_patter1.21435788
57MP0003221_abnormal_cardiomyocyte_apopto1.20549445
58MP0001853_heart_inflammation1.18264937
59MP0000689_abnormal_spleen_morphology1.17985527
60MP0000685_abnormal_immune_system1.17470907
61MP0002085_abnormal_embryonic_tissue1.17409518
62MP0006036_abnormal_mitochondrial_physio1.17232162
63MP0001984_abnormal_olfaction1.17031365
64MP0002722_abnormal_immune_system1.16967092
65MP0002697_abnormal_eye_size1.16869378
66MP0002398_abnormal_bone_marrow1.16403917
67MP0003656_abnormal_erythrocyte_physiolo1.14478020
68MP0000358_abnormal_cell_content/1.14362724
69MP0005391_vision/eye_phenotype1.13544448
70MP0001293_anophthalmia1.11689130
71MP0005187_abnormal_penis_morphology1.11614906
72MP0000703_abnormal_thymus_morphology1.11459916
73MP0009333_abnormal_splenocyte_physiolog1.11443486
74MP0002163_abnormal_gland_morphology1.10999452
75MP0009697_abnormal_copulation1.07989318
76MP0002638_abnormal_pupillary_reflex1.07633246
77MP0002234_abnormal_pharynx_morphology1.06434599
78MP0006276_abnormal_autonomic_nervous1.05121095
79MP0002139_abnormal_hepatobiliary_system1.03967950
80MP0005084_abnormal_gallbladder_morpholo1.02728167
81MP0000465_gastrointestinal_hemorrhage1.02524071
82MP0002210_abnormal_sex_determination1.01303322
83MP0002090_abnormal_vision0.95035172
84MP0001145_abnormal_male_reproductive0.94838212
85MP0005266_abnormal_metabolism0.94541437
86MP0005023_abnormal_wound_healing0.94539265
87MP0003011_delayed_dark_adaptation0.94287560
88MP0002282_abnormal_trachea_morphology0.94236903
89MP0002429_abnormal_blood_cell0.93690840
90MP0005075_abnormal_melanosome_morpholog0.93216802
91MP0001764_abnormal_homeostasis0.92821333
92MP0005360_urolithiasis0.90674586
93MP0002092_abnormal_eye_morphology0.90535874
94MP0000049_abnormal_middle_ear0.88056225
95MP0006035_abnormal_mitochondrial_morpho0.87680183
96MP0001929_abnormal_gametogenesis0.86795484
97MP0000566_synostosis0.86625503
98MP0000598_abnormal_liver_morphology0.86464770
99MP0002009_preneoplasia0.85377358
100MP0001915_intracranial_hemorrhage0.83836188
101MP0002751_abnormal_autonomic_nervous0.83817019
102MP0000631_abnormal_neuroendocrine_gland0.83606287
103MP0001873_stomach_inflammation0.82980060
104MP0001835_abnormal_antigen_presentation0.82421062
105MP0009672_abnormal_birth_weight0.81224012
106MP0000716_abnormal_immune_system0.79558118
107MP0004147_increased_porphyrin_level0.79512359
108MP0009840_abnormal_foam_cell0.79379234
109MP0001348_abnormal_lacrimal_gland0.79113273
110MP0005365_abnormal_bile_salt0.78269723
111MP0002132_abnormal_respiratory_system0.77668524
112MP0000653_abnormal_sex_gland0.76685521
113MP0001299_abnormal_eye_distance/0.76167381
114MP0005384_cellular_phenotype0.76021247
115MP0001661_extended_life_span0.75994513
116MP0005671_abnormal_response_to0.73523730
117MP0002102_abnormal_ear_morphology0.73183710
118MP0003119_abnormal_digestive_system0.73032953
119MP0005408_hypopigmentation0.72624319
120MP0003755_abnormal_palate_morphology0.71704503
121MP0005319_abnormal_enzyme/_coenzyme0.71464283
122MP0003890_abnormal_embryonic-extraembry0.70232992
123MP0000858_altered_metastatic_potential0.69450521
124MP0000477_abnormal_intestine_morphology0.68676553
125MP0005085_abnormal_gallbladder_physiolo0.68508761
126MP0003121_genomic_imprinting0.68124303
127MP0003705_abnormal_hypodermis_morpholog0.67687214
128MP0003698_abnormal_male_reproductive0.67598776
129MP0001346_abnormal_lacrimal_gland0.67334644
130MP0002653_abnormal_ependyma_morphology0.67025402
131MP0005377_hearing/vestibular/ear_phenot0.66847953
132MP0003878_abnormal_ear_physiology0.66847953
133MP0001324_abnormal_eye_pigmentation0.66101594
134MP0002111_abnormal_tail_morphology0.65825495
135MP0005551_abnormal_eye_electrophysiolog0.65748993
136MP0005621_abnormal_cell_physiology0.65703954
137MP0010030_abnormal_orbit_morphology0.65467063
138MP0000609_abnormal_liver_physiology0.65048767
139MP0004133_heterotaxia0.64934538
140MP0003252_abnormal_bile_duct0.64680224
141MP0002160_abnormal_reproductive_system0.62778993
142MP0001800_abnormal_humoral_immune0.61166477
143MP0001119_abnormal_female_reproductive0.60706631
144MP0005220_abnormal_exocrine_pancreas0.60352622
145MP0005389_reproductive_system_phenotype0.60288829
146MP0005076_abnormal_cell_differentiation0.60085052
147MP0003566_abnormal_cell_adhesion0.59089408
148MP0002095_abnormal_skin_pigmentation0.58478616
149MP0002075_abnormal_coat/hair_pigmentati0.58460263

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.38433618
2Abnormality of cells of the erythroid lineage (HP:0012130)4.18618817
3Abnormal number of erythroid precursors (HP:0012131)4.03021670
4Colon cancer (HP:0003003)3.98705999
5Reticulocytopenia (HP:0001896)3.91912734
6Increased hepatocellular lipid droplets (HP:0006565)3.76486038
7Aplastic anemia (HP:0001915)3.53775826
8Oral leukoplakia (HP:0002745)3.52009924
9Hyperglycinemia (HP:0002154)3.50680368
10Lipid accumulation in hepatocytes (HP:0006561)3.46007978
11Acute necrotizing encephalopathy (HP:0006965)3.36102023
12Acute encephalopathy (HP:0006846)3.24331747
13Selective tooth agenesis (HP:0001592)3.20586058
14Ependymoma (HP:0002888)3.15541002
15Abnormal mitochondria in muscle tissue (HP:0008316)3.13672410
16Thrombocytosis (HP:0001894)3.10873616
17Medulloblastoma (HP:0002885)2.99123935
18Mitochondrial inheritance (HP:0001427)2.98864945
19Abnormality of the anterior horn cell (HP:0006802)2.95756356
20Degeneration of anterior horn cells (HP:0002398)2.95756356
21Agnosia (HP:0010524)2.94131515
22Increased CSF lactate (HP:0002490)2.93176338
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.86435290
24Abnormality of alanine metabolism (HP:0010916)2.86435290
25Hyperalaninemia (HP:0003348)2.86435290
26Abnormality of glycolysis (HP:0004366)2.86377368
27Increased serum pyruvate (HP:0003542)2.86377368
28Macrocytic anemia (HP:0001972)2.83754477
2911 pairs of ribs (HP:0000878)2.81852446
30Breast hypoplasia (HP:0003187)2.75884127
31Microretrognathia (HP:0000308)2.74261838
32Hepatocellular necrosis (HP:0001404)2.73638529
33Exercise-induced muscle cramps (HP:0003710)2.72892037
34Multiple enchondromatosis (HP:0005701)2.72339316
35Rhabdomyosarcoma (HP:0002859)2.72303606
36Methylmalonic acidemia (HP:0002912)2.67338553
37Hepatic necrosis (HP:0002605)2.66949780
38Amaurosis fugax (HP:0100576)2.66152522
39Progressive macrocephaly (HP:0004481)2.65959166
40Abnormality of chromosome stability (HP:0003220)2.61976207
41Basal cell carcinoma (HP:0002671)2.60152652
42Cerebral edema (HP:0002181)2.59393473
43Medial flaring of the eyebrow (HP:0010747)2.57599687
44Pallor (HP:0000980)2.57531074
45Supernumerary spleens (HP:0009799)2.55251402
46Cerebral hypomyelination (HP:0006808)2.53907285
47IgM deficiency (HP:0002850)2.52917505
48Hypobetalipoproteinemia (HP:0003563)2.52811761
49Chromsome breakage (HP:0040012)2.50646503
50Abnormality of pyrimidine metabolism (HP:0004353)2.50614325
51Myelodysplasia (HP:0002863)2.49601817
52Carpal bone hypoplasia (HP:0001498)2.48314790
53Increased intramyocellular lipid droplets (HP:0012240)2.45480393
54Spastic diplegia (HP:0001264)2.42893565
55Pancytopenia (HP:0001876)2.40493034
56Neoplasm of the pancreas (HP:0002894)2.39816135
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.38968585
58Abnormal protein N-linked glycosylation (HP:0012347)2.38968585
59Abnormal protein glycosylation (HP:0012346)2.38968585
60Abnormal glycosylation (HP:0012345)2.38968585
61Abnormality of serine family amino acid metabolism (HP:0010894)2.38106870
62Abnormality of glycine metabolism (HP:0010895)2.38106870
63Abnormality of the labia minora (HP:0012880)2.34352150
64Congenital primary aphakia (HP:0007707)2.33118053
65Abnormality of the heme biosynthetic pathway (HP:0010472)2.32986801
66Premature graying of hair (HP:0002216)2.32493830
67Rough bone trabeculation (HP:0100670)2.31774202
68Entropion (HP:0000621)2.31403547
69Progressive muscle weakness (HP:0003323)2.28406761
70Exercise intolerance (HP:0003546)2.28240660
71Renal Fanconi syndrome (HP:0001994)2.26559025
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.22045837
73Triphalangeal thumb (HP:0001199)2.21395567
74Bone marrow hypocellularity (HP:0005528)2.21026377
75Poikiloderma (HP:0001029)2.18653837
76Nephrogenic diabetes insipidus (HP:0009806)2.17298774
77Squamous cell carcinoma (HP:0002860)2.15268467
78Lactic acidosis (HP:0003128)2.14598714
79Hyperglycinuria (HP:0003108)2.13684706
80Megaloblastic anemia (HP:0001889)2.13427927
813-Methylglutaconic aciduria (HP:0003535)2.13210842
82Gait imbalance (HP:0002141)2.09536260
83Reduced antithrombin III activity (HP:0001976)2.09305932
84Meckel diverticulum (HP:0002245)2.09237115
85Abnormality of the preputium (HP:0100587)2.07823069
86Volvulus (HP:0002580)2.07600242
87Abnormality of serum amino acid levels (HP:0003112)2.06644611
88Postnatal microcephaly (HP:0005484)2.06610263
89Missing ribs (HP:0000921)2.04959932
90Neoplasm of the colon (HP:0100273)2.03365195
91Lymphoma (HP:0002665)2.02932904
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.02239175
93Decreased activity of mitochondrial respiratory chain (HP:0008972)2.02239175
94Abnormality of reticulocytes (HP:0004312)2.01558432
95Neoplasm of the rectum (HP:0100743)2.01548529
96Abnormality of the ileum (HP:0001549)2.00380288
97Biliary tract neoplasm (HP:0100574)2.00285768
98Methylmalonic aciduria (HP:0012120)2.00262458
99Patellar aplasia (HP:0006443)2.00097155
100Pancreatic islet-cell hyperplasia (HP:0004510)1.98772042
101Cellular immunodeficiency (HP:0005374)1.96617379
102Abnormality of methionine metabolism (HP:0010901)1.96491797
103Neoplasm of the oral cavity (HP:0100649)1.96419453
104Nephroblastoma (Wilms tumor) (HP:0002667)1.96412744
105Horseshoe kidney (HP:0000085)1.96360923
106Proximal placement of thumb (HP:0009623)1.95230190
107Increased serum lactate (HP:0002151)1.94746346
108Cholecystitis (HP:0001082)1.94676569
109Abnormal gallbladder physiology (HP:0012438)1.94676569
110Myoglobinuria (HP:0002913)1.94665769
111Microvesicular hepatic steatosis (HP:0001414)1.94339566
112Gonadotropin excess (HP:0000837)1.94250044
113Septo-optic dysplasia (HP:0100842)1.93910798
114Aplasia/Hypoplasia of the uvula (HP:0010293)1.93871690
115Absent thumb (HP:0009777)1.93439299
116Tubulointerstitial nephritis (HP:0001970)1.93208983
117Slender long bone (HP:0003100)1.91742666
118Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91391817
119Increased muscle lipid content (HP:0009058)1.89877910
120Sloping forehead (HP:0000340)1.87932368
121Pancreatic fibrosis (HP:0100732)1.87280926
122Deviation of the thumb (HP:0009603)1.87180418
123Impulsivity (HP:0100710)1.86890279
124Abnormal spermatogenesis (HP:0008669)1.86676784
125Atrophy/Degeneration involving motor neurons (HP:0007373)1.86539878
126Muscle fiber atrophy (HP:0100295)1.85484864
127Abnormality of monocarboxylic acid metabolism (HP:0010996)1.85356845
128Type I transferrin isoform profile (HP:0003642)1.84678483
129Median cleft lip (HP:0000161)1.84302116
130Ovarian neoplasm (HP:0100615)1.84282410
131Secondary amenorrhea (HP:0000869)1.84220077
132Hypoglycemic coma (HP:0001325)1.84090401
133Aplasia/Hypoplasia of the patella (HP:0006498)1.83891419
134Pancreatic cysts (HP:0001737)1.83677493
135Abnormality of the calcaneus (HP:0008364)1.83366721
136Cortical dysplasia (HP:0002539)1.83012793
137Embryonal renal neoplasm (HP:0011794)1.82852133
138Trismus (HP:0000211)1.82607653
139Small intestinal stenosis (HP:0012848)1.82276990
140Duodenal stenosis (HP:0100867)1.82276990
141True hermaphroditism (HP:0010459)1.81686331
142Leukodystrophy (HP:0002415)1.80838460
143Rhabdomyolysis (HP:0003201)1.80572840
144Intrahepatic cholestasis (HP:0001406)1.79156489
145Broad foot (HP:0001769)1.78981249
146Type 2 muscle fiber atrophy (HP:0003554)1.78743463
147Hyperinsulinemic hypoglycemia (HP:0000825)1.78309793
148Abnormality of the duodenum (HP:0002246)1.77240922
149Neoplasm of the small intestine (HP:0100833)1.75912716
150Glossoptosis (HP:0000162)1.75558817
151Decreased testicular size (HP:0008734)1.75495920
152Bifid tongue (HP:0010297)1.74822569
153Hypoplastic pelvis (HP:0008839)1.74575738
154Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74161197
155Respiratory difficulties (HP:0002880)1.73749988
156Renal cortical cysts (HP:0000803)1.73402878
157Postaxial foot polydactyly (HP:0001830)1.73201452
158Short tibia (HP:0005736)1.72577984
159Nephronophthisis (HP:0000090)1.72268880
160Abnormal lung lobation (HP:0002101)1.70897530
161Abnormality of DNA repair (HP:0003254)1.70678204
162Astrocytoma (HP:0009592)1.70282699
163Abnormality of the astrocytes (HP:0100707)1.70282699
164Abnormality of T cell physiology (HP:0011840)1.70216114
165Nausea (HP:0002018)1.68550491
166Petechiae (HP:0000967)1.66957283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.42526624
2CDC73.79985929
3BUB13.75932171
4VRK23.18250216
5EIF2AK13.15474079
6MAP4K23.05630920
7PBK2.86660048
8STK162.67266892
9EIF2AK32.52637708
10ACVR1B2.46971490
11NEK12.42645704
12TSSK62.38991635
13BRSK22.31016989
14NEK22.26779304
15TESK22.11462314
16PASK2.01280263
17TRIM281.95334141
18FLT31.95225483
19NME21.89925861
20DYRK31.87809440
21MKNK11.81977815
22TTK1.80617745
23BCR1.76922196
24SCYL21.75880150
25RPS6KB21.73293890
26PLK11.72711339
27SRPK11.70632368
28NUAK11.70584540
29EEF2K1.68082145
30BCKDK1.63043530
31PKN21.62699139
32ATR1.61023062
33MAP3K81.56171715
34TGFBR11.53086217
35STK101.52238648
36TNIK1.50573152
37AURKB1.49790928
38VRK11.46978144
39CDK71.42886889
40RPS6KA41.36357119
41CDK41.33082379
42PLK41.30928785
43ERBB31.27982768
44CDK121.19510878
45WNK31.16325035
46PAK41.14881825
47TAF11.14129452
48PLK31.13288250
49TLK11.11545572
50MAP4K11.10969399
51BRSK11.10039056
52BMPR1B1.09791747
53KDR1.07405657
54LRRK21.07199607
55PDK31.05495645
56PDK41.05495645
57MAP2K31.04760732
58MAPKAPK31.01954419
59AURKA1.01396047
60MKNK20.98800089
61TAOK30.98722400
62CHEK20.98355175
63CHEK10.97319571
64WNK40.97213298
65CSNK1G10.95187258
66KIT0.93716404
67DYRK20.93391074
68PLK20.88648617
69CCNB10.87888308
70CSNK1A1L0.86271818
71CSNK1G20.85733770
72STK40.85326018
73MAP3K40.83054447
74BTK0.81357880
75TESK10.80750927
76TEC0.79612085
77STK30.76943476
78CSF1R0.74378915
79STK390.73739001
80PIM10.73684674
81ATM0.72432042
82CSNK2A20.69900884
83EPHA20.69460313
84CDK20.67435864
85NME10.64972028
86CDK60.64932337
87ZAP700.60349289
88CSNK2A10.59998608
89MAP2K70.58296862
90STK38L0.58135158
91EIF2AK20.57159325
92RPS6KA50.56709957
93MAP3K100.56255015
94MST40.56216841
95CDK80.55641592
96CDK30.55528430
97JAK30.53822718
98LATS10.53640993
99PAK10.53561957
100PIM20.52283598
101GRK60.52150355
102TRIB30.49350364
103NEK90.49116236
104BRD40.49109910
105CDK10.48887352
106CSNK1E0.48182294
107ILK0.43981904
108MAPK110.43662553
109CLK10.43467482
110PINK10.42541769
111PNCK0.42271170
112PAK20.40968579
113MAP3K30.40410930
114ZAK0.39637287
115LIMK10.38944353
116OBSCN0.36659056
117ALK0.36623256
118MAPKAPK50.36340147
119ARAF0.34631923
120EPHA40.33380008
121ERBB40.33211361
122CDK90.32787512
123CDK140.32573575
124AKT20.31996210
125FGFR10.31583135
126TTN0.31100753
127PDK20.30866319
128DAPK10.30366471
129CDK11A0.30017867
130CSNK1A10.29410414
131RAF10.29262097
132GRK10.28624407
133MELK0.28527992
134ITK0.28052645
135CDK180.27845645
136MTOR0.26706519
137NLK0.26562643
138PRKDC0.26245413
139MET0.25490187
140CDK190.24481148
141CSNK1G30.23835304

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.70366013
2Mismatch repair_Homo sapiens_hsa034303.85431040
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.17201019
4Ribosome_Homo sapiens_hsa030102.97277301
5Proteasome_Homo sapiens_hsa030502.96964765
6Spliceosome_Homo sapiens_hsa030402.77966466
7One carbon pool by folate_Homo sapiens_hsa006702.76999949
8Nucleotide excision repair_Homo sapiens_hsa034202.68310132
9Base excision repair_Homo sapiens_hsa034102.67116256
10RNA transport_Homo sapiens_hsa030132.64816466
11* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.63788151
12RNA polymerase_Homo sapiens_hsa030202.54313355
13Homologous recombination_Homo sapiens_hsa034402.37446193
14Cell cycle_Homo sapiens_hsa041102.35104137
15Oxidative phosphorylation_Homo sapiens_hsa001902.21100114
16Pyrimidine metabolism_Homo sapiens_hsa002402.17958953
17Parkinsons disease_Homo sapiens_hsa050122.11301300
18Non-homologous end-joining_Homo sapiens_hsa034501.94544224
19Steroid biosynthesis_Homo sapiens_hsa001001.93997775
20Selenocompound metabolism_Homo sapiens_hsa004501.79361070
21Fatty acid elongation_Homo sapiens_hsa000621.74648051
22Fanconi anemia pathway_Homo sapiens_hsa034601.69349402
23Huntingtons disease_Homo sapiens_hsa050161.56465784
24Biosynthesis of amino acids_Homo sapiens_hsa012301.54054810
25RNA degradation_Homo sapiens_hsa030181.51299799
26Basal transcription factors_Homo sapiens_hsa030221.47261949
27Pentose phosphate pathway_Homo sapiens_hsa000301.45397894
28Folate biosynthesis_Homo sapiens_hsa007901.41837845
29Systemic lupus erythematosus_Homo sapiens_hsa053221.38348115
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38206731
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.38139672
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33636011
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32399730
34Carbon metabolism_Homo sapiens_hsa012001.28521540
35p53 signaling pathway_Homo sapiens_hsa041151.26977760
36mRNA surveillance pathway_Homo sapiens_hsa030151.24289240
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20449175
38Alzheimers disease_Homo sapiens_hsa050101.20208604
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.18153525
40Butanoate metabolism_Homo sapiens_hsa006501.12913324
41Purine metabolism_Homo sapiens_hsa002301.11284480
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07078168
43Antigen processing and presentation_Homo sapiens_hsa046121.04530543
44Protein export_Homo sapiens_hsa030601.02472020
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.97977544
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97474107
47Epstein-Barr virus infection_Homo sapiens_hsa051690.90492947
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89300901
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89056001
50Sulfur relay system_Homo sapiens_hsa041220.87031929
51Vitamin B6 metabolism_Homo sapiens_hsa007500.85381253
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85244237
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85134030
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82255742
55Viral carcinogenesis_Homo sapiens_hsa052030.81579801
56Pyruvate metabolism_Homo sapiens_hsa006200.80337930
57Glutathione metabolism_Homo sapiens_hsa004800.79177602
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74822459
59Propanoate metabolism_Homo sapiens_hsa006400.73325252
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70023588
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69932600
62Herpes simplex infection_Homo sapiens_hsa051680.68828593
63Cardiac muscle contraction_Homo sapiens_hsa042600.68661185
64Legionellosis_Homo sapiens_hsa051340.62454777
65Fatty acid degradation_Homo sapiens_hsa000710.62218800
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61533929
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.61352330
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61118697
69Caffeine metabolism_Homo sapiens_hsa002320.59516828
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56721963
71N-Glycan biosynthesis_Homo sapiens_hsa005100.56474952
72Oocyte meiosis_Homo sapiens_hsa041140.50857297
73Primary immunodeficiency_Homo sapiens_hsa053400.49830661
74HTLV-I infection_Homo sapiens_hsa051660.48507388
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47278128
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46741165
77Nitrogen metabolism_Homo sapiens_hsa009100.45868600
78Peroxisome_Homo sapiens_hsa041460.42964344
79Fructose and mannose metabolism_Homo sapiens_hsa000510.42798833
80Thyroid cancer_Homo sapiens_hsa052160.42413028
81Metabolic pathways_Homo sapiens_hsa011000.41067040
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38662216
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38521079
84Basal cell carcinoma_Homo sapiens_hsa052170.37913844
85Galactose metabolism_Homo sapiens_hsa000520.37396611
86Arginine and proline metabolism_Homo sapiens_hsa003300.35552134
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31666682
88Tryptophan metabolism_Homo sapiens_hsa003800.31439382
89beta-Alanine metabolism_Homo sapiens_hsa004100.30654675
90Alcoholism_Homo sapiens_hsa050340.30619031
91Regulation of autophagy_Homo sapiens_hsa041400.30125396
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28702493
93Chemical carcinogenesis_Homo sapiens_hsa052040.28232493
94Small cell lung cancer_Homo sapiens_hsa052220.27230081
95Measles_Homo sapiens_hsa051620.27129494
96Hedgehog signaling pathway_Homo sapiens_hsa043400.26809944
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26161915
98Apoptosis_Homo sapiens_hsa042100.24454168
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23387250
100Shigellosis_Homo sapiens_hsa051310.23305408
101Hippo signaling pathway_Homo sapiens_hsa043900.22217952
102Arginine biosynthesis_Homo sapiens_hsa002200.21925173
103Fatty acid metabolism_Homo sapiens_hsa012120.21621461
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21280453
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.20588610
106Phototransduction_Homo sapiens_hsa047440.19303527
107Fat digestion and absorption_Homo sapiens_hsa049750.18775266
108Starch and sucrose metabolism_Homo sapiens_hsa005000.16919347
109MicroRNAs in cancer_Homo sapiens_hsa052060.15882158
110Circadian rhythm_Homo sapiens_hsa047100.15221328
111Hematopoietic cell lineage_Homo sapiens_hsa046400.15192430
112TGF-beta signaling pathway_Homo sapiens_hsa043500.15086273
113Renin-angiotensin system_Homo sapiens_hsa046140.14946654
114Vitamin digestion and absorption_Homo sapiens_hsa049770.14800048
115Lysine degradation_Homo sapiens_hsa003100.13765282
116Retinol metabolism_Homo sapiens_hsa008300.13734830
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.13677512
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.12273478
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.11344571
120Wnt signaling pathway_Homo sapiens_hsa043100.09357342
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.06531498

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