DAPK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.67456576
2L-phenylalanine catabolic process (GO:0006559)5.67456576
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.54525610
4L-phenylalanine metabolic process (GO:0006558)5.54525610
5high-density lipoprotein particle remodeling (GO:0034375)4.63887655
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.61338532
7aromatic amino acid family catabolic process (GO:0009074)4.54607574
8protoporphyrinogen IX metabolic process (GO:0046501)4.47725444
9protoporphyrinogen IX biosynthetic process (GO:0006782)4.36226060
10pyrimidine ribonucleoside catabolic process (GO:0046133)4.33540885
11behavioral response to nicotine (GO:0035095)4.22284405
12positive regulation of lipoprotein lipase activity (GO:0051006)4.20847986
13positive regulation of triglyceride lipase activity (GO:0061365)4.20847986
14fucose catabolic process (GO:0019317)4.07909516
15L-fucose metabolic process (GO:0042354)4.07909516
16L-fucose catabolic process (GO:0042355)4.07909516
17regulation of triglyceride catabolic process (GO:0010896)4.07836109
18bile acid biosynthetic process (GO:0006699)4.03344265
19negative regulation of fibrinolysis (GO:0051918)3.99832924
20very-low-density lipoprotein particle assembly (GO:0034379)3.95067549
21heme transport (GO:0015886)3.92236496
22regulation of cholesterol esterification (GO:0010872)3.89963315
23regulation of fibrinolysis (GO:0051917)3.86841474
24cysteine metabolic process (GO:0006534)3.86406164
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.82911225
26reverse cholesterol transport (GO:0043691)3.82179205
27DNA deamination (GO:0045006)3.79615158
28sulfur amino acid catabolic process (GO:0000098)3.76727531
29ethanol oxidation (GO:0006069)3.72703674
30plasma lipoprotein particle assembly (GO:0034377)3.72518023
31ethanol metabolic process (GO:0006067)3.69933152
32protein carboxylation (GO:0018214)3.69054722
33peptidyl-glutamic acid carboxylation (GO:0017187)3.69054722
34glyoxylate metabolic process (GO:0046487)3.67001656
35alpha-linolenic acid metabolic process (GO:0036109)3.66862385
36regulation of protein activation cascade (GO:2000257)3.63731850
37triglyceride homeostasis (GO:0070328)3.62116221
38acylglycerol homeostasis (GO:0055090)3.62116221
39heme metabolic process (GO:0042168)3.61481443
40plasma lipoprotein particle clearance (GO:0034381)3.60274406
41cholesterol efflux (GO:0033344)3.59653594
42tryptophan catabolic process (GO:0006569)3.59644134
43indole-containing compound catabolic process (GO:0042436)3.59644134
44indolalkylamine catabolic process (GO:0046218)3.59644134
45protein-lipid complex remodeling (GO:0034368)3.58859519
46macromolecular complex remodeling (GO:0034367)3.58859519
47plasma lipoprotein particle remodeling (GO:0034369)3.58859519
48phospholipid efflux (GO:0033700)3.57075809
49response to nitrosative stress (GO:0051409)3.56451055
50cellular glucuronidation (GO:0052695)3.48477679
51protein-lipid complex assembly (GO:0065005)3.47721340
52primary alcohol catabolic process (GO:0034310)3.46455370
53intestinal cholesterol absorption (GO:0030299)3.46367137
54negative regulation of protein activation cascade (GO:2000258)3.45656830
55regulation of skeletal muscle contraction (GO:0014819)3.45140830
56bundle of His cell to Purkinje myocyte communication (GO:0086069)3.44049910
57surfactant homeostasis (GO:0043129)3.43603743
58cofactor catabolic process (GO:0051187)3.43553964
59heme biosynthetic process (GO:0006783)3.43354388
60negative regulation of lipase activity (GO:0060192)3.42840704
61regulation of complement activation (GO:0030449)3.42090513
62kynurenine metabolic process (GO:0070189)3.40399423
63urea cycle (GO:0000050)3.39004851
64urea metabolic process (GO:0019627)3.39004851
65regulation of sequestering of triglyceride (GO:0010889)3.38692826
66bile acid metabolic process (GO:0008206)3.37459302
67drug catabolic process (GO:0042737)3.27545949
68tryptophan metabolic process (GO:0006568)3.27049173
69fibrinolysis (GO:0042730)3.26089843
70lysine catabolic process (GO:0006554)3.25267840
71lysine metabolic process (GO:0006553)3.25267840
72aromatic amino acid family metabolic process (GO:0009072)3.24362931
73transcytosis (GO:0045056)3.24081882
74fatty acid elongation (GO:0030497)3.23977183
75porphyrin-containing compound metabolic process (GO:0006778)3.23587127
76actin-myosin filament sliding (GO:0033275)3.22153404
77muscle filament sliding (GO:0030049)3.22153404
78cellular ketone body metabolic process (GO:0046950)3.17335400
79cholesterol homeostasis (GO:0042632)3.16103592
80aldehyde catabolic process (GO:0046185)3.15322307
81glutathione derivative biosynthetic process (GO:1901687)3.14637997
82glutathione derivative metabolic process (GO:1901685)3.14637997
83porphyrin-containing compound biosynthetic process (GO:0006779)3.13511230
84nitrogen cycle metabolic process (GO:0071941)3.11846485
85negative regulation of cholesterol transport (GO:0032375)3.10845213
86negative regulation of sterol transport (GO:0032372)3.10845213
87glucuronate metabolic process (GO:0019585)3.09971749
88uronic acid metabolic process (GO:0006063)3.09971749
89complement activation, alternative pathway (GO:0006957)3.08985836
90coenzyme catabolic process (GO:0009109)3.08221393
91sterol homeostasis (GO:0055092)3.07746004
92cytidine deamination (GO:0009972)3.07574476
93cytidine metabolic process (GO:0046087)3.07574476
94cytidine catabolic process (GO:0006216)3.07574476
95plasma lipoprotein particle organization (GO:0071827)3.07190222
96regulation of memory T cell differentiation (GO:0043380)3.06627590
97opsonization (GO:0008228)3.05422162
98phosphatidylinositol acyl-chain remodeling (GO:0036149)3.04912685
99epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.04906874
100killing of cells of other organism (GO:0031640)3.02572199
101disruption of cells of other organism (GO:0044364)3.02572199
102negative regulation of complement activation (GO:0045916)3.02532485
103short-chain fatty acid metabolic process (GO:0046459)2.99872051
104pyrimidine nucleoside catabolic process (GO:0046135)2.99009527
105protein-lipid complex subunit organization (GO:0071825)2.97006845
106amino-acid betaine metabolic process (GO:0006577)2.94949396
107aspartate family amino acid catabolic process (GO:0009068)2.94578527
108drug metabolic process (GO:0017144)2.93928217
109acute-phase response (GO:0006953)2.93614204
110negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.93529758
111negative regulation of cell killing (GO:0031342)2.93529758
112antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.93256603
113very long-chain fatty acid metabolic process (GO:0000038)2.93075108
114homocysteine metabolic process (GO:0050667)2.92981788
115regulation of relaxation of muscle (GO:1901077)2.91961534
116antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.91641766
117benzene-containing compound metabolic process (GO:0042537)2.91393484
118xenobiotic catabolic process (GO:0042178)2.91236578
119skeletal muscle adaptation (GO:0043501)2.90547964
120hemidesmosome assembly (GO:0031581)2.89897170
121negative regulation of interleukin-1 production (GO:0032692)2.89080941
122exogenous drug catabolic process (GO:0042738)2.81401874
123kidney morphogenesis (GO:0060993)2.78175948
124positive regulation of fatty acid oxidation (GO:0046321)2.78085955
125ketone body metabolic process (GO:1902224)2.77498443
126negative regulation of mast cell activation (GO:0033004)2.75705263
127indolalkylamine metabolic process (GO:0006586)2.72040023
128antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.71795229
129positive regulation of T cell mediated cytotoxicity (GO:0001916)2.67464267
130regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.65052907
131actin-mediated cell contraction (GO:0070252)2.64174367
132myofibril assembly (GO:0030239)2.62144276
133negative regulation of interleukin-1 beta production (GO:0032691)2.61925050
134skeletal muscle contraction (GO:0003009)2.61151927
135antigen processing and presentation of endogenous antigen (GO:0019883)2.60609675
136regulation of T cell mediated cytotoxicity (GO:0001914)2.60140744
137cellular response to interleukin-15 (GO:0071350)2.59689980
138regulation of guanylate cyclase activity (GO:0031282)2.59303189
139sarcoplasmic reticulum calcium ion transport (GO:0070296)2.58911422
140positive regulation of defense response to virus by host (GO:0002230)2.57907989
141negative regulation of telomere maintenance (GO:0032205)2.57016558
142positive regulation of guanylate cyclase activity (GO:0031284)2.56538106
143membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.55262362
144detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.54212376
145macroautophagy (GO:0016236)2.54141748
146detection of light stimulus involved in sensory perception (GO:0050962)2.54012931
147detection of light stimulus involved in visual perception (GO:0050908)2.54012931
148striated muscle atrophy (GO:0014891)2.53531886
149positive regulation of sodium ion transmembrane transport (GO:1902307)2.51359694
150DNA demethylation (GO:0080111)2.50524350
151fatty acid transmembrane transport (GO:1902001)2.50037164
152thyroid hormone metabolic process (GO:0042403)2.48392658
153activated T cell proliferation (GO:0050798)2.46432221
154NAD biosynthetic process (GO:0009435)2.41192582
155primary amino compound metabolic process (GO:1901160)2.40180690
156negative regulation of cAMP-mediated signaling (GO:0043951)2.38153786
157neuronal action potential (GO:0019228)2.37959748
158positive regulation of fatty acid beta-oxidation (GO:0032000)2.36478266
159antigen processing and presentation via MHC class Ib (GO:0002475)2.34399885
160preassembly of GPI anchor in ER membrane (GO:0016254)2.34071040
161regulation of action potential (GO:0098900)2.31064303
162positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.27629785
163regulation of hexokinase activity (GO:1903299)2.26762525
164regulation of glucokinase activity (GO:0033131)2.26762525
165regulation of gamma-delta T cell differentiation (GO:0045586)2.26668762
166adaptation of signaling pathway (GO:0023058)2.23432262
167axoneme assembly (GO:0035082)2.23298635
168positive regulation of antigen processing and presentation (GO:0002579)2.23142894
169response to interleukin-15 (GO:0070672)2.23024324
170alkaloid metabolic process (GO:0009820)2.22978121
171sulfation (GO:0051923)2.21765921
172regulation of hippo signaling (GO:0035330)2.20968432
173auditory receptor cell stereocilium organization (GO:0060088)2.20620899
174basic amino acid transport (GO:0015802)2.18866171
175regulation of gamma-delta T cell activation (GO:0046643)2.18626167
176phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.18180622
177establishment of protein localization to Golgi (GO:0072600)2.16999595
178arginine metabolic process (GO:0006525)2.16787538
179negative regulation of reactive oxygen species metabolic process (GO:2000378)2.16268934
180neural tube formation (GO:0001841)2.16131264
181cAMP catabolic process (GO:0006198)2.15820256
182interkinetic nuclear migration (GO:0022027)2.15265548
183thyroid hormone generation (GO:0006590)2.14828768
184dendritic cell migration (GO:0036336)2.14709502
185cellular response to exogenous dsRNA (GO:0071360)2.14443865
186membrane depolarization during action potential (GO:0086010)2.13481485
187ubiquinone biosynthetic process (GO:0006744)2.12372511
188regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.12343144
189neutrophil activation (GO:0042119)2.11101329

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.47496335
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.43823937
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.93380731
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.89201387
5* EGR1_23403033_ChIP-Seq_LIVER_Mouse4.69285421
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.63017597
7* LXR_22158963_ChIP-Seq_LIVER_Mouse4.38434477
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.77776452
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.47674927
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.36719017
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.26112448
12EZH2_22144423_ChIP-Seq_EOC_Human3.09724844
13ZNF274_21170338_ChIP-Seq_K562_Hela3.09324818
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.59646788
15* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.51878668
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48033815
17GATA1_22025678_ChIP-Seq_K562_Human2.45017672
18VDR_22108803_ChIP-Seq_LS180_Human2.41181089
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.21138251
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20858872
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15107475
22GBX2_23144817_ChIP-Seq_PC3_Human2.14353159
23* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.00470584
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.99419563
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98622659
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.88480671
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.81250671
28SOX2_27498859_Chip-Seq_STOMACH_Mouse1.79323578
29ER_23166858_ChIP-Seq_MCF-7_Human1.78757812
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77817679
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.74820343
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.72499707
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.69822871
34IGF1R_20145208_ChIP-Seq_DFB_Human1.66045295
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.65812524
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64782993
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64704318
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.64248496
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64161703
40CLOCK_20551151_ChIP-Seq_293T_Human1.59468579
41GATA4_25053715_ChIP-Seq_YYC3_Human1.59309111
42GATA1_19941826_ChIP-Seq_K562_Human1.54938965
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54050517
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.53950636
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47823758
46SOX2_20726797_ChIP-Seq_SW620_Human1.47093799
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47084663
48BCAT_22108803_ChIP-Seq_LS180_Human1.45174849
49* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.44461699
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44344569
51P63_26484246_Chip-Seq_KERATINOCYTES_Human1.42474899
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40565876
53CDX2_20551321_ChIP-Seq_CACO-2_Human1.39927462
54* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39147895
55DROSHA_22980978_ChIP-Seq_HELA_Human1.38594131
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35387505
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.34457099
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.31885493
59P300_19829295_ChIP-Seq_ESCs_Human1.31468487
60PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31001837
61* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29463914
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28647619
63GATA2_19941826_ChIP-Seq_K562_Human1.27885594
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27486375
65TP53_22573176_ChIP-Seq_HFKS_Human1.27050321
66ZNF263_19887448_ChIP-Seq_K562_Human1.26738264
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25860037
68TCF4_23295773_ChIP-Seq_U87_Human1.25503290
69AR_21572438_ChIP-Seq_LNCaP_Human1.25156624
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24944388
71* STAT3_23295773_ChIP-Seq_U87_Human1.23945341
72CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22431725
73TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.22046642
74FOXA1_25329375_ChIP-Seq_VCAP_Human1.21171972
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21171972
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18768400
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18768400
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.18673810
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18287833
80AR_25329375_ChIP-Seq_VCAP_Human1.17703547
81SOX2_19829295_ChIP-Seq_ESCs_Human1.17473314
82NANOG_19829295_ChIP-Seq_ESCs_Human1.17473314
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16623672
84ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16373044
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15124354
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14798588
87GATA3_26560356_Chip-Seq_TH2_Human1.14262433
88GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.14108710
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.14067611
90SMAD4_21799915_ChIP-Seq_A2780_Human1.13282009
91* GATA1_19941827_ChIP-Seq_MEL_Mouse1.12296766
92NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10758128
93* RACK7_27058665_Chip-Seq_MCF-7_Human1.10722011
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10694865
95CBP_20019798_ChIP-Seq_JUKART_Human1.10694865
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.10376677
97* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09233228
98AR_20517297_ChIP-Seq_VCAP_Human1.09209557
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08977811
100OCT4_20526341_ChIP-Seq_ESCs_Human1.08935440
101TCF4_22108803_ChIP-Seq_LS180_Human1.08836824
102ERA_21632823_ChIP-Seq_H3396_Human1.08059638
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.07789055
104FOXA2_19822575_ChIP-Seq_HepG2_Human1.07644503
105REST_21632747_ChIP-Seq_MESCs_Mouse1.07097502
106TAF2_19829295_ChIP-Seq_ESCs_Human1.07019692
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.06026889
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05672048
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.05330040
110HOXB7_26014856_ChIP-Seq_BT474_Human1.05245403
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04723104
112GATA6_25053715_ChIP-Seq_YYC3_Human1.04576485
113ESR1_20079471_ChIP-ChIP_T-47D_Human1.04177162
114FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04032618
115TAF15_26573619_Chip-Seq_HEK293_Human1.03592858
116FUS_26573619_Chip-Seq_HEK293_Human1.02748083
117MYC_19829295_ChIP-Seq_ESCs_Human1.02295638
118CBX2_27304074_Chip-Seq_ESCs_Mouse1.00336190
119PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00303532
120FLI1_21867929_ChIP-Seq_TH2_Mouse1.00103120
121TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99113423
122PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98718699
123OCT1_27270436_Chip-Seq_PROSTATE_Human0.98676191
124CRX_20693478_ChIP-Seq_RETINA_Mouse0.98193223
125IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97329992
126BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96981371
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95926719
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95657125
129CDX2_22108803_ChIP-Seq_LS180_Human0.95463724
130* NCOR_22424771_ChIP-Seq_293T_Human0.95417499
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95093290
132* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94978810
133SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94613642
134SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94613642
135STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94562715
136SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94317771
137FOXH1_21741376_ChIP-Seq_EPCs_Human0.94205927
138SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93756294
139EZH2_27294783_Chip-Seq_ESCs_Mouse0.93650862
140FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93335634
141SMAD3_21741376_ChIP-Seq_EPCs_Human0.92967511
142CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92910695
143TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92826061
144* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92379163
145BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.92026043
146AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91817186
147P53_21459846_ChIP-Seq_SAOS-2_Human0.91700744
148ATF3_27146783_Chip-Seq_COLON_Human0.91644271
149EGR1_19032775_ChIP-ChIP_M12_Human0.91596334
150FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91507414
151GATA3_24758297_ChIP-Seq_MCF-7_Human0.89776272
152* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89045200
153TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88627957
154SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88327238
155HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88150649
156KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85437745
157CEBPB_22108803_ChIP-Seq_LS180_Human0.85300011
158LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84958854
159LXR_22292898_ChIP-Seq_THP-1_Human0.84824650
160FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84118113
161ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82375751
162KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81925821
163* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.81808398
164* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.81487732
165* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79763674
166* TBX20_22080862_ChIP-Seq_HEART_Mouse0.79481821
167* TBX20_22328084_ChIP-Seq_HEART_Mouse0.79481821
168NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79399596
169NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79399596
170PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79375972
171RUNX_20019798_ChIP-Seq_JUKART_Human0.79140395
172* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78695867
173FOXA1_25552417_ChIP-Seq_VCAP_Human0.78159931
174CSB_26484114_Chip-Seq_FIBROBLAST_Human0.76279602
175NANOG_20526341_ChIP-Seq_ESCs_Human0.76012274
176GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.75382728
177CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74904381
178GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74534646
179MAF_26560356_Chip-Seq_TH1_Human0.74114604
180* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72812137
181HNF4A_19822575_ChIP-Seq_HepG2_Human0.72510347
182ELK3_25401928_ChIP-Seq_HUVEC_Human0.72308571
183CTCF_20526341_ChIP-Seq_ESCs_Human0.70243131
184CTCF_27219007_Chip-Seq_Bcells_Human0.70025221
185AR_21909140_ChIP-Seq_LNCAP_Human0.69966434
186GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.68301518
187CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.68006573
188RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.67793948
189JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65622432

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.47119079
2MP0002139_abnormal_hepatobiliary_system5.27714825
3MP0005360_urolithiasis4.83423572
4MP0005085_abnormal_gallbladder_physiolo4.37619551
5MP0005365_abnormal_bile_salt3.83769738
6MP0005083_abnormal_biliary_tract3.74192022
7MP0008875_abnormal_xenobiotic_pharmacok3.66059070
8MP0004145_abnormal_muscle_electrophysio3.63627252
9MP0003806_abnormal_nucleotide_metabolis3.49645934
10MP0002837_dystrophic_cardiac_calcinosis2.93654252
11MP0003656_abnormal_erythrocyte_physiolo2.87069045
12MP0002254_reproductive_system_inflammat2.82678526
13MP0004130_abnormal_muscle_cell2.66848039
14MP0001666_abnormal_nutrient_absorption2.62914446
15MP0003724_increased_susceptibility_to2.56876501
16MP0002138_abnormal_hepatobiliary_system2.46829940
17MP0010329_abnormal_lipoprotein_level2.43943824
18MP0004147_increased_porphyrin_level2.34686615
19MP0004043_abnormal_pH_regulation2.29056275
20MP0005167_abnormal_blood-brain_barrier2.22498536
21MP0009379_abnormal_foot_pigmentation2.19064802
22MP0010368_abnormal_lymphatic_system2.06104998
23MP0004036_abnormal_muscle_relaxation2.04118352
24MP0004084_abnormal_cardiac_muscle2.03286940
25MP0009840_abnormal_foam_cell2.01986272
26MP0002132_abnormal_respiratory_system1.97693469
27MP0000569_abnormal_digit_pigmentation1.96092232
28MP0003252_abnormal_bile_duct1.92411948
29MP0006054_spinal_hemorrhage1.90764258
30MP0004484_altered_response_of1.88364610
31MP0003191_abnormal_cellular_cholesterol1.86055148
32MP0001346_abnormal_lacrimal_gland1.84668926
33MP0005332_abnormal_amino_acid1.83802248
34MP0008872_abnormal_physiological_respon1.83490079
35MP0003011_delayed_dark_adaptation1.78347390
36MP0001986_abnormal_taste_sensitivity1.77900784
37MP0003300_gastrointestinal_ulcer1.73309867
38MP0005645_abnormal_hypothalamus_physiol1.73045731
39MP0001501_abnormal_sleep_pattern1.68418573
40MP0008004_abnormal_stomach_pH1.62523678
41MP0005551_abnormal_eye_electrophysiolog1.62223882
42MP0005620_abnormal_muscle_contractility1.58390082
43MP0004019_abnormal_vitamin_homeostasis1.57266153
44MP0002332_abnormal_exercise_endurance1.56481601
45MP0005671_abnormal_response_to1.53055591
46MP0004215_abnormal_myocardial_fiber1.52148231
47MP0002102_abnormal_ear_morphology1.51195391
48MP0005451_abnormal_body_composition1.50703217
49MP0000609_abnormal_liver_physiology1.48787480
50MP0004885_abnormal_endolymph1.46315913
51MP0003137_abnormal_impulse_conducting1.44688168
52MP0002118_abnormal_lipid_homeostasis1.42874597
53MP0008877_abnormal_DNA_methylation1.42475322
54MP0002796_impaired_skin_barrier1.40169251
55MP0000749_muscle_degeneration1.39471073
56MP0001851_eye_inflammation1.38422157
57MP0000230_abnormal_systemic_arterial1.38351254
58MP0003045_fibrosis1.38283589
59MP0003195_calcinosis1.36788434
60MP0002106_abnormal_muscle_physiology1.35899886
61MP0000685_abnormal_immune_system1.35867930
62MP0002638_abnormal_pupillary_reflex1.35253406
63MP0004782_abnormal_surfactant_physiolog1.35168067
64MP0009643_abnormal_urine_homeostasis1.34546710
65MP0009764_decreased_sensitivity_to1.32942046
66MP0000427_abnormal_hair_cycle1.32052788
67MP0002098_abnormal_vibrissa_morphology1.28882276
68MP0004142_abnormal_muscle_tone1.27369365
69MP0003453_abnormal_keratinocyte_physiol1.25985829
70MP0003186_abnormal_redox_activity1.25604249
71MP0001542_abnormal_bone_strength1.24477916
72MP0010234_abnormal_vibrissa_follicle1.23788036
73MP0000383_abnormal_hair_follicle1.23053293
74MP0008775_abnormal_heart_ventricle1.21892692
75MP0002060_abnormal_skin_morphology1.21004222
76MP0005319_abnormal_enzyme/_coenzyme1.19679527
77MP0005584_abnormal_enzyme/coenzyme_acti1.19561930
78MP0005636_abnormal_mineral_homeostasis1.18317503
79MP0001800_abnormal_humoral_immune1.17869590
80MP0001968_abnormal_touch/_nociception1.17137595
81MP0001485_abnormal_pinna_reflex1.17014019
82MP0009745_abnormal_behavioral_response1.16722606
83MP0005253_abnormal_eye_physiology1.14727403
84MP0005369_muscle_phenotype1.14297924
85MP0003950_abnormal_plasma_membrane1.13645552
86MP0001873_stomach_inflammation1.12711717
87MP0005408_hypopigmentation1.12373154
88MP0005174_abnormal_tail_pigmentation1.08779419
89MP0002972_abnormal_cardiac_muscle1.08495020
90MP0004947_skin_inflammation1.06924547
91MP0000751_myopathy1.06306974
92MP0001879_abnormal_lymphatic_vessel1.06070709
93MP0006082_CNS_inflammation1.05946841
94MP0010678_abnormal_skin_adnexa1.04835132
95MP0002653_abnormal_ependyma_morphology1.03768112
96MP0001835_abnormal_antigen_presentation1.02229298
97MP0005266_abnormal_metabolism1.02006910
98MP0000579_abnormal_nail_morphology1.00667764
99MP0009785_altered_susceptibility_to1.00058758
100MP0005646_abnormal_pituitary_gland0.99706063
101MP0005385_cardiovascular_system_phenoty0.97548383
102MP0001544_abnormal_cardiovascular_syste0.97548383
103MP0002693_abnormal_pancreas_physiology0.97039493
104MP0004085_abnormal_heartbeat0.96564505
105MP0002723_abnormal_immune_serum0.96272978
106MP0002733_abnormal_thermal_nociception0.95998737
107MP0004883_abnormal_blood_vessel0.94813838
108MP0003879_abnormal_hair_cell0.94695568
109MP0005448_abnormal_energy_balance0.94292654
110MP0001765_abnormal_ion_homeostasis0.92896760
111MP0002735_abnormal_chemical_nociception0.92821883
112MP0005535_abnormal_body_temperature0.90537846
113MP0001764_abnormal_homeostasis0.90515774
114MP0005386_behavior/neurological_phenoty0.89641653
115MP0004924_abnormal_behavior0.89641653
116MP0009763_increased_sensitivity_to0.89616207
117MP0002148_abnormal_hypersensitivity_rea0.89298494
118MP0002272_abnormal_nervous_system0.89068892
119MP0010155_abnormal_intestine_physiology0.88802147
120MP0000762_abnormal_tongue_morphology0.88722295
121MP0000013_abnormal_adipose_tissue0.88677794
122MP0001486_abnormal_startle_reflex0.87491283
123MP0000613_abnormal_salivary_gland0.86799140
124MP0008469_abnormal_protein_level0.86145273
125MP0002127_abnormal_cardiovascular_syste0.85643781
126MP0005501_abnormal_skin_physiology0.85364303
127MP0001970_abnormal_pain_threshold0.85208537
128MP0003787_abnormal_imprinting0.82825143
129MP0002277_abnormal_respiratory_mucosa0.82077651
130MP0000750_abnormal_muscle_regeneration0.80804182
131MP0005025_abnormal_response_to0.79827668
132MP0002078_abnormal_glucose_homeostasis0.79698781
133MP0004272_abnormal_basement_membrane0.79426308
134MP0002420_abnormal_adaptive_immunity0.78931455
135MP0000372_irregular_coat_pigmentation0.78809510
136MP0001664_abnormal_digestion0.78726603
137MP0009765_abnormal_xenobiotic_induced0.77918395
138MP0006036_abnormal_mitochondrial_physio0.77561199
139MP0001790_abnormal_immune_system0.77496410
140MP0005387_immune_system_phenotype0.77496410
141MP0002419_abnormal_innate_immunity0.77257363
142MP0005330_cardiomyopathy0.77110770
143MP0001819_abnormal_immune_cell0.77046796
144MP0005377_hearing/vestibular/ear_phenot0.76710267
145MP0003878_abnormal_ear_physiology0.76710267
146MP0003868_abnormal_feces_composition0.75961012
147MP0001216_abnormal_epidermal_layer0.75629193
148MP0003638_abnormal_response/metabolism_0.75177878
149MP0005000_abnormal_immune_tolerance0.74929940
150MP0009046_muscle_twitch0.74317857
151MP0005164_abnormal_response_to0.74194015
152MP0002452_abnormal_antigen_presenting0.73916465
153MP0010771_integument_phenotype0.73735364
154MP0003329_amyloid_beta_deposits0.73336635
155MP0002136_abnormal_kidney_physiology0.73301724
156MP0001243_abnormal_dermal_layer0.72851862
157MP0001663_abnormal_digestive_system0.70450905
158MP0000920_abnormal_myelination0.70405174
159MP0003763_abnormal_thymus_physiology0.69202921
160MP0001191_abnormal_skin_condition0.69148448
161MP0009384_cardiac_valve_regurgitation0.68632512
162MP0002405_respiratory_system_inflammati0.67082876
163MP0000604_amyloidosis0.66699589
164MP0009931_abnormal_skin_appearance0.65626499
165MP0000566_synostosis0.65360560
166MP0005023_abnormal_wound_healing0.65181095
167MP0000598_abnormal_liver_morphology0.63601075
168MP0004264_abnormal_extraembryonic_tissu0.63465270
169MP0002876_abnormal_thyroid_physiology0.63382375
170MP0001845_abnormal_inflammatory_respons0.62439267
171MP0002933_joint_inflammation0.61492011
172MP0000747_muscle_weakness0.59001544
173MP0005376_homeostasis/metabolism_phenot0.56753278
174MP0005166_decreased_susceptibility_to0.56439172
175MP0005381_digestive/alimentary_phenotyp0.56216428
176MP0000003_abnormal_adipose_tissue0.55875646
177MP0000467_abnormal_esophagus_morphology0.54601160

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.97583675
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.89422997
3Intrahepatic cholestasis (HP:0001406)4.67617886
4Xanthomatosis (HP:0000991)4.21513765
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.20019775
6Prolonged partial thromboplastin time (HP:0003645)4.04611898
7Congenital stationary night blindness (HP:0007642)3.91817079
8Muscle hypertrophy of the lower extremities (HP:0008968)3.77707951
9Hypobetalipoproteinemia (HP:0003563)3.68834266
10Pancreatic cysts (HP:0001737)3.56677257
11Calf muscle hypertrophy (HP:0008981)3.54556202
12Ileus (HP:0002595)3.36781881
13Abnormality of the heme biosynthetic pathway (HP:0010472)3.33539824
14Right ventricular cardiomyopathy (HP:0011663)3.33187597
15Poikilocytosis (HP:0004447)3.24533615
16Decreased circulating renin level (HP:0003351)3.22012353
17Amniotic constriction ring (HP:0009775)3.19942747
18Abnormality of placental membranes (HP:0011409)3.19942747
19Abnormality of the renal cortex (HP:0011035)3.17149668
20Hyperventilation (HP:0002883)3.17025402
21Acanthocytosis (HP:0001927)3.16942039
22Type II lissencephaly (HP:0007260)3.13145230
23Hypolipoproteinemia (HP:0010981)3.12183540
24Onycholysis (HP:0001806)3.07915118
25Vascular calcification (HP:0004934)3.04201968
26Molar tooth sign on MRI (HP:0002419)3.02743560
27Abnormality of midbrain morphology (HP:0002418)3.02743560
28Cholelithiasis (HP:0001081)2.99790687
29Hypoalphalipoproteinemia (HP:0003233)2.99113030
30Hyperammonemia (HP:0001987)2.98480984
31Muscle fiber inclusion bodies (HP:0100299)2.96044367
32Hyperbilirubinemia (HP:0002904)2.94561126
33Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.93467887
34Hyperlipoproteinemia (HP:0010980)2.92391185
35Pancreatic fibrosis (HP:0100732)2.92342964
36Abnormal gallbladder morphology (HP:0012437)2.90774650
37Diaphragmatic weakness (HP:0009113)2.89188372
38Fat malabsorption (HP:0002630)2.88017583
39Stomatitis (HP:0010280)2.87552147
40Nemaline bodies (HP:0003798)2.86247836
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.80890272
42Nonimmune hydrops fetalis (HP:0001790)2.80799671
43True hermaphroditism (HP:0010459)2.76212873
44Joint hemorrhage (HP:0005261)2.74009064
45Abnormality of fatty-acid metabolism (HP:0004359)2.71078938
46Nephronophthisis (HP:0000090)2.69989483
47Popliteal pterygium (HP:0009756)2.66850861
48Inability to walk (HP:0002540)2.66820366
49Abnormality of glutamine family amino acid metabolism (HP:0010902)2.65895985
50Cardiovascular calcification (HP:0011915)2.65884534
51Exercise-induced myalgia (HP:0003738)2.65812146
52Attenuation of retinal blood vessels (HP:0007843)2.64581262
53Abnormality of the common coagulation pathway (HP:0010990)2.59515366
54Polycythemia (HP:0001901)2.59508676
55Large for gestational age (HP:0001520)2.57041363
56Paralysis (HP:0003470)2.56613280
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.55017218
58Abnormality of alanine metabolism (HP:0010916)2.55017218
59Hyperalaninemia (HP:0003348)2.55017218
60Exercise-induced muscle cramps (HP:0003710)2.54769511
61Retrobulbar optic neuritis (HP:0100654)2.52413239
62Optic neuritis (HP:0100653)2.52413239
63Abnormal drinking behavior (HP:0030082)2.52133828
64Polydipsia (HP:0001959)2.52133828
65Hypochromic microcytic anemia (HP:0004840)2.47493710
66Abnormality of aspartate family amino acid metabolism (HP:0010899)2.46805934
67Complement deficiency (HP:0004431)2.46661663
68Myositis (HP:0100614)2.46656565
69Hypothermia (HP:0002045)2.45829359
70Abnormality of the renal medulla (HP:0100957)2.43052495
71Abnormality of methionine metabolism (HP:0010901)2.42686862
72Round ear (HP:0100830)2.41570302
73Fragile nails (HP:0001808)2.40870329
74Thyroid-stimulating hormone excess (HP:0002925)2.38388831
75Tubular atrophy (HP:0000092)2.36144147
76Weak cry (HP:0001612)2.35775772
77Orchitis (HP:0100796)2.35721672
78Hyporeflexia of lower limbs (HP:0002600)2.35671597
79Hyperkalemia (HP:0002153)2.34222681
80Cholecystitis (HP:0001082)2.33209471
81Abnormal gallbladder physiology (HP:0012438)2.33209471
82Abnormal delayed hypersensitivity skin test (HP:0002963)2.32958800
83Progressive inability to walk (HP:0002505)2.31444237
84Abnormality of transition element cation homeostasis (HP:0011030)2.31238818
85Epidermoid cyst (HP:0200040)2.30787512
86Distal arthrogryposis (HP:0005684)2.28701920
87Abnormality of sulfur amino acid metabolism (HP:0004339)2.28058799
88Elevated erythrocyte sedimentation rate (HP:0003565)2.27214337
89Abnormality of iron homeostasis (HP:0011031)2.26477058
90Ketosis (HP:0001946)2.26474863
91Abnormality of dicarboxylic acid metabolism (HP:0010995)2.25959942
92Dicarboxylic aciduria (HP:0003215)2.25959942
93Reticulocytosis (HP:0001923)2.25636698
94Amyloidosis (HP:0011034)2.25200642
95Hepatocellular carcinoma (HP:0001402)2.23995146
96Respiratory distress (HP:0002098)2.22693454
97Muscle fiber atrophy (HP:0100295)2.22335736
98Abnormality of the intrinsic pathway (HP:0010989)2.21419141
99Facial diplegia (HP:0001349)2.20591184
100Microcytic anemia (HP:0001935)2.20388131
101EMG: myopathic abnormalities (HP:0003458)2.20298832
102Steatorrhea (HP:0002570)2.19571456
103Hypoglycemic coma (HP:0001325)2.18795949
104Abnormal rod and cone electroretinograms (HP:0008323)2.18350204
105Metabolic acidosis (HP:0001942)2.17611263
106Esophageal varix (HP:0002040)2.17162974
107Abolished electroretinogram (ERG) (HP:0000550)2.16989838
108Autoimmune hemolytic anemia (HP:0001890)2.15763627
109Abnormality of purine metabolism (HP:0004352)2.15279214
110Decreased electroretinogram (ERG) amplitude (HP:0000654)2.14617673
111Dynein arm defect of respiratory motile cilia (HP:0012255)2.14546674
112Absent/shortened dynein arms (HP:0200106)2.14546674
113Rickets (HP:0002748)2.13795982
114Muscle fiber splitting (HP:0003555)2.13654852
115Abnormality of the calf musculature (HP:0001430)2.13070101
116Type 2 muscle fiber atrophy (HP:0003554)2.12329701
117Plantar hyperkeratosis (HP:0007556)2.12092770
118Abnormality of the gallbladder (HP:0005264)2.11135688
119Birth length less than 3rd percentile (HP:0003561)2.09876471
120Stomach cancer (HP:0012126)2.09355895
121Decreased central vision (HP:0007663)2.08900074
122Abnormality of the neuromuscular junction (HP:0003398)2.08618876
123Fatigable weakness (HP:0003473)2.08618876
124Increased serum ferritin (HP:0003281)2.07073966
125Genetic anticipation (HP:0003743)2.06862749
126Abnormality of glycine metabolism (HP:0010895)2.05756754
127Abnormality of serine family amino acid metabolism (HP:0010894)2.05756754
128Bundle branch block (HP:0011710)2.05657586
129Congenital sensorineural hearing impairment (HP:0008527)2.05417423
130Gaze-evoked nystagmus (HP:0000640)2.04635607
131Polyuria (HP:0000103)2.01751232
132Renal cortical cysts (HP:0000803)2.01661321
133Congenital, generalized hypertrichosis (HP:0004540)2.00884708
134Parakeratosis (HP:0001036)2.00556528
135Clumsiness (HP:0002312)2.00182613
136Abnormality of nucleobase metabolism (HP:0010932)1.99369762
137Absent phalangeal crease (HP:0006109)1.98484537
138Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.98421994
139Medial flaring of the eyebrow (HP:0010747)1.98315494
140Myoglobinuria (HP:0002913)1.97460182
141Abnormality of renin-angiotensin system (HP:0000847)1.97403798
142Lethargy (HP:0001254)1.96974371
143Hypophosphatemic rickets (HP:0004912)1.96193575
144Type 1 muscle fiber predominance (HP:0003803)1.95450433
145Pancreatitis (HP:0001733)1.95384415
146Gout (HP:0001997)1.95284589
147Difficulty running (HP:0009046)1.95232198
148Abnormality of complement system (HP:0005339)1.95031853
149Pustule (HP:0200039)1.94871952
150Cerebral palsy (HP:0100021)1.94783187
151Distal lower limb muscle weakness (HP:0009053)1.94487641
152Lissencephaly (HP:0001339)1.93301372
153Malnutrition (HP:0004395)1.93011446
154Metabolic alkalosis (HP:0200114)1.92946879
155Myocardial infarction (HP:0001658)1.92827860
156Cystic liver disease (HP:0006706)1.92759437
157Conjugated hyperbilirubinemia (HP:0002908)1.92337131
158Abnormal hemoglobin (HP:0011902)1.91646898
159Abnormality of potassium homeostasis (HP:0011042)1.91271601
160Abnormality of urine glucose concentration (HP:0011016)1.90419677
161Glycosuria (HP:0003076)1.90419677
162Cerebral edema (HP:0002181)1.88805528
163Frequent falls (HP:0002359)1.88378000
164Keratoconjunctivitis (HP:0001096)1.86544567
165Ventricular fibrillation (HP:0001663)1.86326248
166Rimmed vacuoles (HP:0003805)1.85232543
167Pigmentary retinal degeneration (HP:0001146)1.84855815
168Prolonged QT interval (HP:0001657)1.83399575
169Broad-based gait (HP:0002136)1.83160004
170Encephalitis (HP:0002383)1.82909541
171Hypochromic anemia (HP:0001931)1.82882851
172Cerebellar dysplasia (HP:0007033)1.81701440
173Ketoacidosis (HP:0001993)1.81625638
174Abnormal respiratory epithelium morphology (HP:0012253)1.80877457
175Abnormal respiratory motile cilium morphology (HP:0005938)1.80877457
176Furrowed tongue (HP:0000221)1.80472886
177Chorioretinal atrophy (HP:0000533)1.79126651
178Syncope (HP:0001279)1.77929233
179Myopathic facies (HP:0002058)1.77681184
180Hypokalemia (HP:0002900)1.77426832
181Ulnar deviation of the wrist (HP:0003049)1.75909030
182Severe muscular hypotonia (HP:0006829)1.75591208
183Tachypnea (HP:0002789)1.74805002
184Areflexia of lower limbs (HP:0002522)1.74381407
185Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73981152
186Progressive cerebellar ataxia (HP:0002073)1.72603085
187IgG deficiency (HP:0004315)1.72207253
188Chronic hepatic failure (HP:0100626)1.71692191
189Increased corneal curvature (HP:0100692)1.71425851
190Keratoconus (HP:0000563)1.71425851
191Left ventricular hypertrophy (HP:0001712)1.70080895

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.85488944
2ACVR1B3.60575529
3EPHB13.06394421
4ADRBK23.01900824
5BMPR1B2.82824658
6BCKDK2.68591125
7TIE12.59241160
8PINK12.51551412
9FGFR42.48033902
10MAP4K12.35521659
11TAOK32.34127439
12PHKG22.30373561
13PHKG12.30373561
14MAP3K32.28092457
15EPHB22.16058158
16MST42.08684954
17STK391.93946241
18MAP2K21.93257629
19MAP2K61.88883449
20TGFBR21.83164690
21PIK3CG1.75241464
22MAP4K21.74220802
23MAP3K111.72547864
24ERN11.71006385
25MAP2K31.69398174
26BCR1.66876635
27STK101.66171801
28NME11.59271607
29MST1R1.59157172
30OBSCN1.53770705
31TNK21.49857643
32FGFR21.47035300
33PTK2B1.45208149
34INSRR1.43684929
35MAPK151.43338551
36ZAK1.40768072
37MAPK131.40473271
38ADRBK11.40177751
39PBK1.37637096
40MOS1.34253509
41EPHA31.31285606
42BLK1.23303112
43MAPK111.23100596
44IRAK41.19481749
45WNK31.18565905
46TXK1.17361082
47IKBKE1.17143426
48TBK11.17058808
49TYK21.16042954
50MAPKAPK51.15894813
51OXSR11.14112752
52ITK1.12618506
53IRAK11.11492383
54CAMKK21.10467876
55ZAP701.10234587
56MAP2K11.08488186
57NEK91.06823003
58PAK31.04209507
59SYK1.03401741
60EPHA21.03023702
61LMTK21.01645707
62JAK10.98964183
63WNK40.98918623
64LRRK20.98056721
65TRPM70.97916705
66CASK0.97709556
67MAP3K100.94052721
68RIPK40.93925355
69TGFBR10.93224152
70GRK60.93182804
71CSK0.92606173
72CAMK2G0.92599129
73RPS6KB20.91884638
74GRK50.90510777
75JAK20.89991892
76MAP3K20.89948623
77FRK0.88470011
78PRKAA20.87268758
79NUAK10.85851497
80MAP2K40.85811624
81MAP3K140.85614828
82GRK10.84912136
83MAPK120.84314134
84CAMK10.81780088
85PRKG20.81704300
86MET0.81005743
87KIT0.80002277
88CSNK1G10.77125099
89CDK190.77042151
90LIMK10.75955690
91PRKCH0.74822432
92PRKCQ0.74759002
93TRIB30.74029814
94WNK10.73213707
95NLK0.71357098
96PTK20.70950009
97FES0.70765638
98SIK10.69752335
99MUSK0.68226059
100CAMK40.67794845
101STK110.67592863
102CAMKK10.65839523
103MYLK0.65655799
104PTK60.65482334
105RPS6KA60.64703673
106PRKCE0.64323086
107CDK60.62911477
108CLK10.61465452
109STK38L0.61104987
110MAP3K10.60927806
111GSK3A0.60345241
112MAPKAPK30.59336956
113LYN0.59207064
114TLK10.58722842
115PDK20.58191285
116CDK90.58137723
117STK40.56735958
118IKBKB0.56090280
119LCK0.53957212
120TEC0.53901815
121TNIK0.53830300
122TAOK10.53603592
123NME20.53536403
124HCK0.53085699
125CSNK1A1L0.52259145
126ERBB40.51925966
127CAMK2A0.51718019
128MAPKAPK20.51074555
129PRKAA10.51041553
130SGK20.51040116
131CSNK1G30.50856201
132FER0.50761925
133MAP3K40.49734794
134EIF2AK10.47658681
135PRKACA0.47280607
136PRKG10.46443529
137MAP3K70.46382089
138PKN10.45221397
139TTN0.44687972
140JAK30.44203890
141BTK0.44176991
142PDK10.43884620
143SIK20.43706673
144GRK70.43356124
145SGK4940.43253759
146SGK2230.43253759
147AKT30.42754712
148PRKCI0.41242466
149PRKCZ0.40907995
150PIK3CA0.40817624
151AURKA0.40403679
152RPS6KA50.37821618
153CHUK0.36660046
154NTRK30.34633724
155ERBB20.34161370

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.50903633
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.02174446
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.96271665
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.65146349
5Sulfur metabolism_Homo sapiens_hsa009202.59220224
6Histidine metabolism_Homo sapiens_hsa003402.53006092
7Chemical carcinogenesis_Homo sapiens_hsa052042.45283089
8Complement and coagulation cascades_Homo sapiens_hsa046102.40561263
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.33625820
10Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.32783111
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29432847
12Fatty acid degradation_Homo sapiens_hsa000712.28686627
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.28584108
14Nitrogen metabolism_Homo sapiens_hsa009102.22141639
15Phototransduction_Homo sapiens_hsa047442.17086115
16Tryptophan metabolism_Homo sapiens_hsa003802.16103584
17Fatty acid elongation_Homo sapiens_hsa000622.11987842
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.04606642
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.01065731
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.98564457
21Peroxisome_Homo sapiens_hsa041461.93503598
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.90976843
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.90175022
24Arginine biosynthesis_Homo sapiens_hsa002201.89858680
25Caffeine metabolism_Homo sapiens_hsa002321.88954308
26Propanoate metabolism_Homo sapiens_hsa006401.78577578
27Folate biosynthesis_Homo sapiens_hsa007901.76809259
28Retinol metabolism_Homo sapiens_hsa008301.76657156
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.72388350
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65677053
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64568406
32PPAR signaling pathway_Homo sapiens_hsa033201.61263658
33Glutathione metabolism_Homo sapiens_hsa004801.60507574
34Autoimmune thyroid disease_Homo sapiens_hsa053201.60283069
35Butanoate metabolism_Homo sapiens_hsa006501.60019942
36Fat digestion and absorption_Homo sapiens_hsa049751.55514228
37Cardiac muscle contraction_Homo sapiens_hsa042601.54514324
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.45659529
39beta-Alanine metabolism_Homo sapiens_hsa004101.44921971
40ABC transporters_Homo sapiens_hsa020101.44335723
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.43148608
42Sulfur relay system_Homo sapiens_hsa041221.40568082
43Staphylococcus aureus infection_Homo sapiens_hsa051501.39790374
44Fatty acid metabolism_Homo sapiens_hsa012121.38348484
45Steroid biosynthesis_Homo sapiens_hsa001001.38316092
46Pyruvate metabolism_Homo sapiens_hsa006201.36763106
47Allograft rejection_Homo sapiens_hsa053301.34604028
48Vitamin B6 metabolism_Homo sapiens_hsa007501.33988096
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29756524
50Type I diabetes mellitus_Homo sapiens_hsa049401.23552730
51Phenylalanine metabolism_Homo sapiens_hsa003601.19711286
52Bile secretion_Homo sapiens_hsa049761.19531208
53Tyrosine metabolism_Homo sapiens_hsa003501.16989859
54Vascular smooth muscle contraction_Homo sapiens_hsa042701.15345588
55Calcium signaling pathway_Homo sapiens_hsa040201.13883713
56Morphine addiction_Homo sapiens_hsa050321.12904751
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11696311
58Vitamin digestion and absorption_Homo sapiens_hsa049771.11399185
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11176036
60Arginine and proline metabolism_Homo sapiens_hsa003301.11119042
61Starch and sucrose metabolism_Homo sapiens_hsa005001.10443159
62Insulin secretion_Homo sapiens_hsa049111.10378827
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.09817696
64Regulation of autophagy_Homo sapiens_hsa041401.08943749
65Ovarian steroidogenesis_Homo sapiens_hsa049131.08262187
66Olfactory transduction_Homo sapiens_hsa047401.07670485
67Serotonergic synapse_Homo sapiens_hsa047261.04660104
68Circadian rhythm_Homo sapiens_hsa047101.02890462
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02454599
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01569924
71Circadian entrainment_Homo sapiens_hsa047130.94566403
72Oxytocin signaling pathway_Homo sapiens_hsa049210.88296739
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86905892
74Selenocompound metabolism_Homo sapiens_hsa004500.85681266
75Dilated cardiomyopathy_Homo sapiens_hsa054140.85503306
76Taste transduction_Homo sapiens_hsa047420.85106630
77Ribosome_Homo sapiens_hsa030100.84582718
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83307979
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80977471
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.80559635
81Dorso-ventral axis formation_Homo sapiens_hsa043200.80462433
82Carbon metabolism_Homo sapiens_hsa012000.79906316
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79136881
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78418505
85Nicotine addiction_Homo sapiens_hsa050330.77497522
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77131997
87Gastric acid secretion_Homo sapiens_hsa049710.74455908
88Salivary secretion_Homo sapiens_hsa049700.73976374
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73805564
90Asthma_Homo sapiens_hsa053100.73064275
91Linoleic acid metabolism_Homo sapiens_hsa005910.72186278
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70308044
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70220709
94Oxidative phosphorylation_Homo sapiens_hsa001900.69996443
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69981756
96Renin secretion_Homo sapiens_hsa049240.69437969
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.69127337
98Pentose phosphate pathway_Homo sapiens_hsa000300.66055401
99GABAergic synapse_Homo sapiens_hsa047270.64281184
100Malaria_Homo sapiens_hsa051440.63343436
101Graft-versus-host disease_Homo sapiens_hsa053320.61685641
102Platelet activation_Homo sapiens_hsa046110.59525326
103Long-term depression_Homo sapiens_hsa047300.58986507
104Glutamatergic synapse_Homo sapiens_hsa047240.57761151
105Glycerolipid metabolism_Homo sapiens_hsa005610.57343378
106Metabolic pathways_Homo sapiens_hsa011000.56792989
107cAMP signaling pathway_Homo sapiens_hsa040240.55948396
108Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55881858
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.55800207
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54048692
111T cell receptor signaling pathway_Homo sapiens_hsa046600.54005830
112Biosynthesis of amino acids_Homo sapiens_hsa012300.53285410
113Arachidonic acid metabolism_Homo sapiens_hsa005900.52820297
114Parkinsons disease_Homo sapiens_hsa050120.51781862
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51555644
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50896332
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50542879
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50350180
119Pancreatic secretion_Homo sapiens_hsa049720.48385167
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48179678
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48033756
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46696046
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.45570783
124Primary immunodeficiency_Homo sapiens_hsa053400.41339427
125Ether lipid metabolism_Homo sapiens_hsa005650.37168672
126Alzheimers disease_Homo sapiens_hsa050100.35411050
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.28592219
128Protein digestion and absorption_Homo sapiens_hsa049740.27542369
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26883146
130Hematopoietic cell lineage_Homo sapiens_hsa046400.24844671
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24244464
132Tight junction_Homo sapiens_hsa045300.23263008
133ECM-receptor interaction_Homo sapiens_hsa045120.23181276
134* Bladder cancer_Homo sapiens_hsa052190.22417962
135Antigen processing and presentation_Homo sapiens_hsa046120.20213986
136Hepatitis C_Homo sapiens_hsa051600.19732091
137Proteasome_Homo sapiens_hsa030500.16843805
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15153147
139Mineral absorption_Homo sapiens_hsa049780.15085993
140Systemic lupus erythematosus_Homo sapiens_hsa053220.13134799
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.10691654
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.09908343
143Huntingtons disease_Homo sapiens_hsa050160.07851889
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.07203478
145Protein export_Homo sapiens_hsa030600.07016435
146Insulin resistance_Homo sapiens_hsa049310.06202482
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.06064633

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