DAND5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)6.46326544
2regulation of cilium movement (GO:0003352)5.81358017
3behavioral response to nicotine (GO:0035095)5.76828110
4protoporphyrinogen IX biosynthetic process (GO:0006782)5.11605639
5tricarboxylic acid cycle (GO:0006099)4.79627267
6fucose catabolic process (GO:0019317)4.77966402
7L-fucose metabolic process (GO:0042354)4.77966402
8L-fucose catabolic process (GO:0042355)4.77966402
9succinate metabolic process (GO:0006105)4.36947514
10protoporphyrinogen IX metabolic process (GO:0046501)4.35841923
11acrosome reaction (GO:0007340)4.18791315
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.12757844
13axonemal dynein complex assembly (GO:0070286)4.02494637
14sperm motility (GO:0030317)3.96921504
15NADH metabolic process (GO:0006734)3.95927257
16calcium ion-dependent exocytosis (GO:0017156)3.88112170
17synaptic vesicle exocytosis (GO:0016079)3.86125418
18positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.80788284
19negative regulation of appetite (GO:0032099)3.79676067
20negative regulation of response to food (GO:0032096)3.79676067
21indolalkylamine metabolic process (GO:0006586)3.78899509
22protein localization to cilium (GO:0061512)3.76828426
23striatum development (GO:0021756)3.75940155
24kynurenine metabolic process (GO:0070189)3.73523565
25DNA deamination (GO:0045006)3.68626716
26ATP hydrolysis coupled proton transport (GO:0015991)3.68120840
27energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.68120840
28water-soluble vitamin biosynthetic process (GO:0042364)3.64653884
29response to pheromone (GO:0019236)3.64156044
30tryptophan catabolic process (GO:0006569)3.62790393
31indole-containing compound catabolic process (GO:0042436)3.62790393
32indolalkylamine catabolic process (GO:0046218)3.62790393
33fusion of sperm to egg plasma membrane (GO:0007342)3.59546811
34protein-cofactor linkage (GO:0018065)3.57672107
35cellular ketone body metabolic process (GO:0046950)3.53260858
36heme biosynthetic process (GO:0006783)3.52513375
37detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.52270274
38acrosome assembly (GO:0001675)3.49651616
39signal peptide processing (GO:0006465)3.47271960
40melanosome transport (GO:0032402)3.46270364
41tryptophan metabolic process (GO:0006568)3.45790478
42piRNA metabolic process (GO:0034587)3.43291391
43regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.38996505
44negative regulation of cAMP-mediated signaling (GO:0043951)3.36719924
45negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.35858902
46neuronal action potential (GO:0019228)3.35651225
47regulation of microtubule-based movement (GO:0060632)3.33819753
48microtubule severing (GO:0051013)3.32440144
49motile cilium assembly (GO:0044458)3.31836636
50regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.30229399
51regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.30229399
52regulation of acyl-CoA biosynthetic process (GO:0050812)3.29865654
53regulation of response to food (GO:0032095)3.28511186
54primary amino compound metabolic process (GO:1901160)3.27909660
55L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.27256367
56retinal rod cell development (GO:0046548)3.26950836
57platelet dense granule organization (GO:0060155)3.26394677
58pigment granule transport (GO:0051904)3.23791421
59negative regulation of telomere maintenance (GO:0032205)3.22134609
60establishment of melanosome localization (GO:0032401)3.21761921
61mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.20862013
62mitochondrial respiratory chain complex I assembly (GO:0032981)3.20862013
63porphyrin-containing compound biosynthetic process (GO:0006779)3.18949354
64transferrin transport (GO:0033572)3.18802858
65ketone body metabolic process (GO:1902224)3.18261618
66regulation of action potential (GO:0098900)3.15672623
67nephron tubule morphogenesis (GO:0072078)3.14556583
68nephron epithelium morphogenesis (GO:0072088)3.14556583
69protein insertion into membrane (GO:0051205)3.14538426
70sperm-egg recognition (GO:0035036)3.12791866
71serotonin metabolic process (GO:0042428)3.12248456
72indole-containing compound metabolic process (GO:0042430)3.12248188
73fucosylation (GO:0036065)3.11215079
74epithelial cilium movement (GO:0003351)3.10293081
75regulation of cofactor metabolic process (GO:0051193)3.09805911
76regulation of coenzyme metabolic process (GO:0051196)3.09805911
77mitochondrial respiratory chain complex assembly (GO:0033108)3.08479142
78cilium movement (GO:0003341)3.07092750
79regulation of appetite (GO:0032098)3.07084879
80sensory perception of smell (GO:0007608)3.06978948
81axoneme assembly (GO:0035082)3.06850762
82nonmotile primary cilium assembly (GO:0035058)3.06170500
83preassembly of GPI anchor in ER membrane (GO:0016254)3.06055805
84protein complex biogenesis (GO:0070271)3.04931221
85oxaloacetate metabolic process (GO:0006107)3.04087424
86lactate metabolic process (GO:0006089)3.03056536
87behavioral response to ethanol (GO:0048149)3.02811669
88regulation of synaptic vesicle transport (GO:1902803)3.01487322
89establishment of pigment granule localization (GO:0051905)3.01418769
90positive regulation of action potential (GO:0045760)3.01382003
91regulation of synaptic vesicle exocytosis (GO:2000300)3.00823526
92heart process (GO:0003015)2.98529907
93heart contraction (GO:0060047)2.98529907
94plasma membrane fusion (GO:0045026)2.97764249
95negative regulation of cytosolic calcium ion concentration (GO:0051481)2.97226697
96protein polyglutamylation (GO:0018095)2.96835556
97melanosome localization (GO:0032400)2.96650341
98multicellular organism reproduction (GO:0032504)2.95064033
99ubiquinone biosynthetic process (GO:0006744)2.94145607
100negative regulation of mast cell activation (GO:0033004)2.93583481
101regulation of hexokinase activity (GO:1903299)2.92483529
102regulation of glucokinase activity (GO:0033131)2.92483529
103synaptic vesicle docking involved in exocytosis (GO:0016081)2.90737577
104cytochrome complex assembly (GO:0017004)2.89792718
105negative regulation of cell killing (GO:0031342)2.89530016
106negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.89530016
107binding of sperm to zona pellucida (GO:0007339)2.89417582
108tetrapyrrole biosynthetic process (GO:0033014)2.88760716
109phagosome maturation (GO:0090382)2.88673010
110trivalent inorganic cation transport (GO:0072512)2.88009866
111ferric iron transport (GO:0015682)2.88009866
112detection of light stimulus involved in sensory perception (GO:0050962)2.87716001
113detection of light stimulus involved in visual perception (GO:0050908)2.87716001
114adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.84238652
115ATP synthesis coupled proton transport (GO:0015986)2.84214016
116energy coupled proton transport, down electrochemical gradient (GO:0015985)2.84214016
117cell wall macromolecule catabolic process (GO:0016998)2.83163072
118cell wall macromolecule metabolic process (GO:0044036)2.83163072
119ubiquinone metabolic process (GO:0006743)2.82604837
120regulation of sodium ion transmembrane transporter activity (GO:2000649)2.82510978
121positive regulation of mitochondrial fission (GO:0090141)2.79790033
122pigment granule localization (GO:0051875)2.79048767
123inositol phosphate catabolic process (GO:0071545)2.78942416
124sulfation (GO:0051923)2.78472225
125DNA methylation involved in gamete generation (GO:0043046)2.77526107
126regulation of inclusion body assembly (GO:0090083)2.77236673
127heme metabolic process (GO:0042168)2.75986531
128cornea development in camera-type eye (GO:0061303)2.75961704
129regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.75104844
130phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.73366200
131neurotransmitter-gated ion channel clustering (GO:0072578)2.72227560
132mitochondrial fission (GO:0000266)2.71653842
133reflex (GO:0060004)2.71133550
134cell-cell recognition (GO:0009988)2.70349246
135barbed-end actin filament capping (GO:0051016)2.70344833
136respiratory chain complex IV assembly (GO:0008535)2.70216891
137membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.70137349
138gamma-aminobutyric acid transport (GO:0015812)2.68746909
139positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.68253964
140negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66989873
141regulation of nuclear cell cycle DNA replication (GO:0033262)2.66118560
142cilium morphogenesis (GO:0060271)2.65193349
143glycolytic process (GO:0006096)2.65057447
144polyamine metabolic process (GO:0006595)2.64119491
145mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.63984576
146sperm capacitation (GO:0048240)2.63590471
147regulation of synaptic transmission, dopaminergic (GO:0032225)2.62940997
148protein-chromophore linkage (GO:0018298)2.62857638
149membrane depolarization during action potential (GO:0086010)2.62539424
150negative regulation of heart rate (GO:0010459)2.62376743
151negative regulation of multicellular organism growth (GO:0040015)2.61816008
152kidney morphogenesis (GO:0060993)2.61605755
153detection of calcium ion (GO:0005513)2.61441631
154NADH dehydrogenase complex assembly (GO:0010257)2.61087720
155positive regulation of fatty acid transport (GO:2000193)2.59933211
156photoreceptor cell development (GO:0042461)2.59931999
157synaptic transmission, cholinergic (GO:0007271)2.59001552
158alanine transport (GO:0032328)2.58859945
159GPI anchor metabolic process (GO:0006505)2.57555673
160somite development (GO:0061053)2.57468699
161mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.53903481
162positive regulation of defense response to virus by host (GO:0002230)2.53627841
163cilium organization (GO:0044782)2.51288255
164protein K11-linked deubiquitination (GO:0035871)2.50986988
165parturition (GO:0007567)2.50894314
166negative regulation of transcription regulatory region DNA binding (GO:2000678)2.49380205
167adaptation of signaling pathway (GO:0023058)2.48911554
168renal tubule morphogenesis (GO:0061333)2.48502444
169G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.48086740
170reciprocal DNA recombination (GO:0035825)2.48007568
171reciprocal meiotic recombination (GO:0007131)2.48007568
172glycerophospholipid catabolic process (GO:0046475)2.47737065
173cellular biogenic amine catabolic process (GO:0042402)2.45246654
174amine catabolic process (GO:0009310)2.45246654
175positive regulation of triglyceride biosynthetic process (GO:0010867)2.44522185
176regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.41949829
177cilium or flagellum-dependent cell motility (GO:0001539)2.41892480
178cilium assembly (GO:0042384)2.41028894
179retinal cone cell development (GO:0046549)2.40047392
180positive regulation of sodium ion transmembrane transport (GO:1902307)2.39179467
181phosphatidylinositol acyl-chain remodeling (GO:0036149)2.37382919
182dopamine transport (GO:0015872)2.37278033
183cAMP catabolic process (GO:0006198)2.36780244
184centriole replication (GO:0007099)2.36700843
185regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.36131012

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.37041413
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.28361123
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.80529406
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.73227941
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53477046
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.41021745
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39929234
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.27221533
9IGF1R_20145208_ChIP-Seq_DFB_Human2.17212851
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.14372305
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10005706
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.09226471
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05613556
14EWS_26573619_Chip-Seq_HEK293_Human2.00045171
15REST_21632747_ChIP-Seq_MESCs_Mouse1.99469909
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99057994
17FUS_26573619_Chip-Seq_HEK293_Human1.97064775
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.94351751
19TAF15_26573619_Chip-Seq_HEK293_Human1.93770780
20ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.92923146
21CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.92153920
22P300_19829295_ChIP-Seq_ESCs_Human1.87555577
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.87049884
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87025766
25ER_23166858_ChIP-Seq_MCF-7_Human1.86305055
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.84371850
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81438952
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.72368216
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.69399822
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.65820810
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61678846
32MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.59164795
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.59007319
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.56821988
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.56267089
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.53643097
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52549268
38ZNF274_21170338_ChIP-Seq_K562_Hela1.52204635
39IRF1_19129219_ChIP-ChIP_H3396_Human1.51645602
40BCAT_22108803_ChIP-Seq_LS180_Human1.51415341
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50758292
42* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.50645024
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50210173
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50055505
45CTCF_18555785_ChIP-Seq_MESCs_Mouse1.49685440
46MYC_18940864_ChIP-ChIP_HL60_Human1.47519161
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47148297
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47045461
49EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.46665185
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46494793
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46112477
52CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.43198839
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42393914
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41667473
55* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.38473477
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37966165
57FOXA1_25329375_ChIP-Seq_VCAP_Human1.37137476
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37137476
59EST1_17652178_ChIP-ChIP_JURKAT_Human1.36649228
60STAT3_23295773_ChIP-Seq_U87_Human1.34355246
61RARB_27405468_Chip-Seq_BRAIN_Mouse1.34252964
62AR_25329375_ChIP-Seq_VCAP_Human1.34251299
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.33001808
64GBX2_23144817_ChIP-Seq_PC3_Human1.32949381
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32722746
66ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32209888
67RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.32038996
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31923120
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31923120
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31740613
71NANOG_19829295_ChIP-Seq_ESCs_Human1.31653531
72SOX2_19829295_ChIP-Seq_ESCs_Human1.31653531
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31376016
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30478788
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27838662
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27206756
77RNF2_27304074_Chip-Seq_NSC_Mouse1.26954773
78SMAD4_21799915_ChIP-Seq_A2780_Human1.25918985
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.25590430
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.25014912
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24752616
82TCF4_23295773_ChIP-Seq_U87_Human1.24336221
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23878952
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23850370
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.23505729
86KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.23372982
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23312125
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22741631
89EED_16625203_ChIP-ChIP_MESCs_Mouse1.22699946
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22596599
91TCF4_22108803_ChIP-Seq_LS180_Human1.21683247
92IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20306448
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20030668
94* BCL6_27268052_Chip-Seq_Bcells_Human1.19914953
95GATA3_21867929_ChIP-Seq_CD8_Mouse1.19440334
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18537563
97YY1_22570637_ChIP-Seq_MALME-3M_Human1.18330611
98EZH2_27294783_Chip-Seq_NPCs_Mouse1.16180532
99HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.16142790
100HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15861759
101EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.15524565
102HOXB7_26014856_ChIP-Seq_BT474_Human1.15054277
103RUNX2_22187159_ChIP-Seq_PCA_Human1.14809927
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14749803
105CBP_20019798_ChIP-Seq_JUKART_Human1.13314761
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13314761
107EZH2_27304074_Chip-Seq_ESCs_Mouse1.13109825
108FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11377613
109SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10845883
110AR_20517297_ChIP-Seq_VCAP_Human1.10354775
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.10273744
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09416387
113TET1_21451524_ChIP-Seq_MESCs_Mouse1.08887786
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08473914
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08427546
116VDR_22108803_ChIP-Seq_LS180_Human1.08211606
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07616167
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.06985262
119* ELF1_20517297_ChIP-Seq_JURKAT_Human1.06900184
120PRDM14_20953172_ChIP-Seq_ESCs_Human1.06439997
121PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05711614
122* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04809700
123JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02243975
124AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02240739
125ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02095726
126RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01453253
127ERA_21632823_ChIP-Seq_H3396_Human1.00776983
128SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00696337
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00145726
130CRX_20693478_ChIP-Seq_RETINA_Mouse0.99701474
131CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98974893
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98937169
133EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98572324
134POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98304634
135SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98248277
136E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97953710
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96274924
138PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96100130
139P53_22387025_ChIP-Seq_ESCs_Mouse0.95751065
140NANOG_18555785_Chip-Seq_ESCs_Mouse0.95711857
141SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95609737
142CTCF_26484167_Chip-Seq_Bcells_Mouse0.94276009
143OCT4_20526341_ChIP-Seq_ESCs_Human0.93680037
144FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93627485
145GATA3_21867929_ChIP-Seq_TH1_Mouse0.93128613
146TP53_22573176_ChIP-Seq_HFKS_Human0.93033045
147STAT1_17558387_ChIP-Seq_HELA_Human0.92864342
148GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92447882
149MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92110837
150GATA1_19941827_ChIP-Seq_MEL_Mouse0.91823468
151POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91206227
152THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91176940
153CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90363947
154EZH2_27294783_Chip-Seq_ESCs_Mouse0.89635151
155PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87922047
156CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.87218648
157* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86743660
158SOX2_22085726_ChIP-Seq_NPCs_Mouse0.85838778
159SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85326399
160NANOG_20526341_ChIP-Seq_ESCs_Human0.85108759
161CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84917459
162FLI1_21867929_ChIP-Seq_TH2_Mouse0.82448897
163FOXH1_21741376_ChIP-Seq_ESCs_Human0.81534454
164GABP_19822575_ChIP-Seq_HepG2_Human0.79931302
165ERG_20517297_ChIP-Seq_VCAP_Human0.79869183
166CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79853310
167ETS1_21867929_ChIP-Seq_TH2_Mouse0.76594621
168GABP_17652178_ChIP-ChIP_JURKAT_Human0.76060752
169RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.75530283
170VDR_23849224_ChIP-Seq_CD4+_Human0.75518422
171CTCF_20526341_ChIP-Seq_ESCs_Human0.75061450
172CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.74781538
173NCOR_22424771_ChIP-Seq_293T_Human0.74169656
174DROSHA_22980978_ChIP-Seq_HELA_Human0.73853057
175MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.73814312
176HOXB4_20404135_ChIP-ChIP_EML_Mouse0.73388414
177PHF8_20622854_ChIP-Seq_HELA_Human0.72977555

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction5.84554961
2MP0002837_dystrophic_cardiac_calcinosis3.82786492
3MP0005410_abnormal_fertilization3.72641866
4MP0003646_muscle_fatigue3.58389948
5MP0008877_abnormal_DNA_methylation2.94603337
6MP0003787_abnormal_imprinting2.57300807
7MP0009046_muscle_twitch2.52252003
8MP0002102_abnormal_ear_morphology2.31032200
9MP0005646_abnormal_pituitary_gland2.29338020
10MP0006036_abnormal_mitochondrial_physio2.28178638
11MP0002909_abnormal_adrenal_gland2.26737816
12MP0003136_yellow_coat_color2.21480654
13MP0004885_abnormal_endolymph2.12592895
14MP0002653_abnormal_ependyma_morphology2.08768247
15MP0003011_delayed_dark_adaptation2.04596520
16MP0000569_abnormal_digit_pigmentation2.01058975
17MP0008875_abnormal_xenobiotic_pharmacok1.97633811
18MP0004036_abnormal_muscle_relaxation1.97625928
19MP0008789_abnormal_olfactory_epithelium1.96559204
20MP0004215_abnormal_myocardial_fiber1.89480315
21MP0004142_abnormal_muscle_tone1.86956462
22MP0000013_abnormal_adipose_tissue1.84534908
23MP0004859_abnormal_synaptic_plasticity1.84489835
24MP0002064_seizures1.82816408
25MP0004084_abnormal_cardiac_muscle1.81215536
26MP0000372_irregular_coat_pigmentation1.80371064
27MP0005253_abnormal_eye_physiology1.79542066
28MP0000749_muscle_degeneration1.76976498
29MP0000751_myopathy1.75998317
30MP0001502_abnormal_circadian_rhythm1.74600098
31MP0003635_abnormal_synaptic_transmissio1.72321075
32MP0004147_increased_porphyrin_level1.71165150
33MP0002938_white_spotting1.70455588
34MP0002734_abnormal_mechanical_nocicepti1.69805585
35MP0002638_abnormal_pupillary_reflex1.67704679
36MP0005084_abnormal_gallbladder_morpholo1.66020994
37MP0000427_abnormal_hair_cycle1.63859902
38MP0001485_abnormal_pinna_reflex1.62704204
39MP0005394_taste/olfaction_phenotype1.59937885
40MP0005499_abnormal_olfactory_system1.59937885
41MP0003195_calcinosis1.54675061
42MP0003122_maternal_imprinting1.54390660
43MP0002572_abnormal_emotion/affect_behav1.52891482
44MP0002736_abnormal_nociception_after1.50343622
45MP0003879_abnormal_hair_cell1.48692309
46MP0002876_abnormal_thyroid_physiology1.48441603
47MP0001501_abnormal_sleep_pattern1.46541837
48MP0004270_analgesia1.46302669
49MP0004043_abnormal_pH_regulation1.45803421
50MP0001968_abnormal_touch/_nociception1.44424719
51MP0002272_abnormal_nervous_system1.43818683
52MP0005551_abnormal_eye_electrophysiolog1.42539890
53* MP0004133_heterotaxia1.42188784
54MP0002063_abnormal_learning/memory/cond1.41330859
55MP0009745_abnormal_behavioral_response1.41144975
56MP0006035_abnormal_mitochondrial_morpho1.40996545
57MP0003183_abnormal_peptide_metabolism1.40743958
58MP0003698_abnormal_male_reproductive1.39814444
59MP0002277_abnormal_respiratory_mucosa1.37875770
60MP0004742_abnormal_vestibular_system1.37532995
61MP0003329_amyloid_beta_deposits1.36929075
62MP0001986_abnormal_taste_sensitivity1.35007653
63MP0004145_abnormal_muscle_electrophysio1.34870122
64MP0004233_abnormal_muscle_weight1.32733146
65MP0005174_abnormal_tail_pigmentation1.28181849
66MP0001929_abnormal_gametogenesis1.27745849
67MP0004130_abnormal_muscle_cell1.27630540
68MP0000015_abnormal_ear_pigmentation1.26084474
69MP0005075_abnormal_melanosome_morpholog1.22083433
70MP0005389_reproductive_system_phenotype1.21889749
71MP0001944_abnormal_pancreas_morphology1.21384150
72MP0002693_abnormal_pancreas_physiology1.20920511
73MP0003656_abnormal_erythrocyte_physiolo1.20835381
74MP0002928_abnormal_bile_duct1.20758655
75MP0003283_abnormal_digestive_organ1.20731683
76MP0003806_abnormal_nucleotide_metabolis1.19444737
77MP0001486_abnormal_startle_reflex1.18681294
78MP0002138_abnormal_hepatobiliary_system1.18671333
79MP0005645_abnormal_hypothalamus_physiol1.18388128
80MP0002160_abnormal_reproductive_system1.16458278
81MP0008995_early_reproductive_senescence1.15581411
82MP0003121_genomic_imprinting1.15514141
83MP0001905_abnormal_dopamine_level1.15444205
84MP0006276_abnormal_autonomic_nervous1.15173163
85MP0002735_abnormal_chemical_nociception1.14462219
86MP0002234_abnormal_pharynx_morphology1.13308329
87MP0002067_abnormal_sensory_capabilities1.10725736
88MP0001919_abnormal_reproductive_system1.09917451
89MP0003890_abnormal_embryonic-extraembry1.09636254
90MP0010386_abnormal_urinary_bladder1.08545321
91MP0000678_abnormal_parathyroid_gland1.07600827
92MP0002557_abnormal_social/conspecific_i1.04875525
93MP0001970_abnormal_pain_threshold1.04736957
94MP0005195_abnormal_posterior_eye1.04373519
95MP0002095_abnormal_skin_pigmentation1.03663273
96MP0003137_abnormal_impulse_conducting1.02556984
97MP0003878_abnormal_ear_physiology1.02073419
98MP0005377_hearing/vestibular/ear_phenot1.02073419
99MP0002078_abnormal_glucose_homeostasis1.00612106
100MP0002184_abnormal_innervation0.99191128
101MP0000383_abnormal_hair_follicle0.98993683
102MP0009780_abnormal_chondrocyte_physiolo0.98362574
103MP0002822_catalepsy0.98054248
104MP0005085_abnormal_gallbladder_physiolo0.97851376
105MP0004085_abnormal_heartbeat0.97446230
106MP0001529_abnormal_vocalization0.96772274
107MP0002269_muscular_atrophy0.95414493
108MP0005620_abnormal_muscle_contractility0.95199897
109MP0003880_abnormal_central_pattern0.94695881
110MP0004924_abnormal_behavior0.94486525
111MP0005386_behavior/neurological_phenoty0.94486525
112MP0002751_abnormal_autonomic_nervous0.92835088
113MP0000026_abnormal_inner_ear0.92706087
114MP0005423_abnormal_somatic_nervous0.90458933
115MP0004811_abnormal_neuron_physiology0.87685974
116MP0001324_abnormal_eye_pigmentation0.86343767
117MP0002972_abnormal_cardiac_muscle0.86045454
118MP0000604_amyloidosis0.84937414
119MP0005409_darkened_coat_color0.84728354
120MP0002163_abnormal_gland_morphology0.84287463
121MP0004484_altered_response_of0.84200030
122MP0002752_abnormal_somatic_nervous0.84171669
123MP0001835_abnormal_antigen_presentation0.83491086
124MP0000647_abnormal_sebaceous_gland0.83251714
125MP0000778_abnormal_nervous_system0.81632253
126MP0005083_abnormal_biliary_tract0.80486213
127MP0005220_abnormal_exocrine_pancreas0.80245255
128MP0003252_abnormal_bile_duct0.79017908
129MP0004510_myositis0.78856486
130MP0002733_abnormal_thermal_nociception0.78794386
131MP0002106_abnormal_muscle_physiology0.78457383
132MP0006292_abnormal_olfactory_placode0.78365362
133MP0003718_maternal_effect0.78172928
134MP0008260_abnormal_autophagy0.76796769
135MP0002161_abnormal_fertility/fecundity0.76777241
136MP0009333_abnormal_splenocyte_physiolog0.75877764
137MP0006072_abnormal_retinal_apoptosis0.75372621
138MP0001765_abnormal_ion_homeostasis0.74846689
139MP0002933_joint_inflammation0.74716500
140MP0008569_lethality_at_weaning0.74220478
141MP0002229_neurodegeneration0.73854578
142MP0005330_cardiomyopathy0.73828628
143MP0001188_hyperpigmentation0.73823903
144MP0002210_abnormal_sex_determination0.73138212
145MP0000230_abnormal_systemic_arterial0.72326959
146MP0009379_abnormal_foot_pigmentation0.72103292
147MP0003953_abnormal_hormone_level0.70571408
148MP0000631_abnormal_neuroendocrine_gland0.69882095
149MP0008872_abnormal_physiological_respon0.69191684
150MP0005535_abnormal_body_temperature0.69083597
151MP0000759_abnormal_skeletal_muscle0.68036875
152MP0008775_abnormal_heart_ventricle0.67676014

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.75251157
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.56027249
3Abnormality of the heme biosynthetic pathway (HP:0010472)4.29001491
4Absent/shortened dynein arms (HP:0200106)4.25908655
5Dynein arm defect of respiratory motile cilia (HP:0012255)4.25908655
6Focal motor seizures (HP:0011153)4.06692261
7Abnormal mitochondria in muscle tissue (HP:0008316)3.88693140
8Nephronophthisis (HP:0000090)3.81106688
9Type II lissencephaly (HP:0007260)3.80916445
10Acute necrotizing encephalopathy (HP:0006965)3.62159066
11Medial flaring of the eyebrow (HP:0010747)3.60895410
12Abnormal respiratory motile cilium physiology (HP:0012261)3.53698900
13Hepatocellular necrosis (HP:0001404)3.49509105
14Cerebral palsy (HP:0100021)3.47682230
15Gait imbalance (HP:0002141)3.30863861
16Congenital primary aphakia (HP:0007707)3.27207249
17Abnormality of the renal medulla (HP:0100957)3.24399613
18Abnormality of macular pigmentation (HP:0008002)3.15018609
19Mitochondrial inheritance (HP:0001427)3.12794025
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.10141032
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.10141032
22Hepatic necrosis (HP:0002605)3.09935919
23Severe visual impairment (HP:0001141)3.09593506
24Progressive macrocephaly (HP:0004481)3.09072392
25Abnormality of alanine metabolism (HP:0010916)3.08562235
26Hyperalaninemia (HP:0003348)3.08562235
27Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.08562235
28Abnormality of the renal cortex (HP:0011035)3.06857947
29Nephrogenic diabetes insipidus (HP:0009806)3.01233091
30Chronic bronchitis (HP:0004469)2.98652157
31Cystic liver disease (HP:0006706)2.97562209
32Abolished electroretinogram (ERG) (HP:0000550)2.96890308
33Acute encephalopathy (HP:0006846)2.96542594
34Rhinitis (HP:0012384)2.94058640
35Abnormal drinking behavior (HP:0030082)2.89281035
36Polydipsia (HP:0001959)2.89281035
37Chronic hepatic failure (HP:0100626)2.86600184
38Febrile seizures (HP:0002373)2.84924085
39Abnormal respiratory epithelium morphology (HP:0012253)2.79805467
40Abnormal respiratory motile cilium morphology (HP:0005938)2.79805467
41Bile duct proliferation (HP:0001408)2.79427915
42Abnormal biliary tract physiology (HP:0012439)2.79427915
43Tubular atrophy (HP:0000092)2.73729581
44Pendular nystagmus (HP:0012043)2.72128530
45Constricted visual fields (HP:0001133)2.70396028
46Increased CSF lactate (HP:0002490)2.70383271
47Epileptic encephalopathy (HP:0200134)2.63029985
48Atonic seizures (HP:0010819)2.62355321
493-Methylglutaconic aciduria (HP:0003535)2.62262950
50Exercise-induced myalgia (HP:0003738)2.61288095
51Palpitations (HP:0001962)2.60398911
52Cerebellar dysplasia (HP:0007033)2.60131906
53Hyperventilation (HP:0002883)2.57214394
54Abnormal ciliary motility (HP:0012262)2.55803744
55Broad face (HP:0000283)2.54590438
56Myoglobinuria (HP:0002913)2.53576869
57Attenuation of retinal blood vessels (HP:0007843)2.51594753
58Neuroendocrine neoplasm (HP:0100634)2.50489234
59Sclerocornea (HP:0000647)2.48391496
60Infertility (HP:0000789)2.46410428
61Congenital, generalized hypertrichosis (HP:0004540)2.45278978
62Abnormality of B cell number (HP:0010975)2.44583648
63B lymphocytopenia (HP:0010976)2.44583648
64Left ventricular hypertrophy (HP:0001712)2.44114772
65Paralysis (HP:0003470)2.43870027
66Bronchitis (HP:0012387)2.42580396
67Male pseudohermaphroditism (HP:0000037)2.41374493
68Inability to walk (HP:0002540)2.40962215
69Central scotoma (HP:0000603)2.39028526
70Progressive inability to walk (HP:0002505)2.38657104
71Optic disc pallor (HP:0000543)2.38391208
72Pheochromocytoma (HP:0002666)2.38138571
73Large for gestational age (HP:0001520)2.34655132
74Poor coordination (HP:0002370)2.33052328
75Abnormal rod and cone electroretinograms (HP:0008323)2.29161241
76Lactic acidosis (HP:0003128)2.28990626
77Lissencephaly (HP:0001339)2.27692768
78Cholecystitis (HP:0001082)2.26914290
79Abnormal gallbladder physiology (HP:0012438)2.26914290
80Large eyes (HP:0001090)2.26323894
81Anencephaly (HP:0002323)2.25923796
82Polyuria (HP:0000103)2.25592404
83Furrowed tongue (HP:0000221)2.24481913
84Keratoconus (HP:0000563)2.23787798
85Increased corneal curvature (HP:0100692)2.23787798
86Lipid accumulation in hepatocytes (HP:0006561)2.22309373
87Retinal dysplasia (HP:0007973)2.18766132
88Aplasia/Hypoplasia of the tongue (HP:0010295)2.17438456
89Concave nail (HP:0001598)2.16953521
90Abnormality of the pons (HP:0007361)2.16943018
91Congenital hepatic fibrosis (HP:0002612)2.15242946
92Ragged-red muscle fibers (HP:0003200)2.15008171
93Decreased circulating renin level (HP:0003351)2.11672658
94Brushfield spots (HP:0001088)2.10547139
95Hypoplasia of the pons (HP:0012110)2.09228615
96Congenital stationary night blindness (HP:0007642)2.08728093
97Respiratory failure (HP:0002878)2.08060690
98Renal cortical cysts (HP:0000803)2.06345007
99Aplasia/Hypoplasia of the tibia (HP:0005772)2.06217251
100True hermaphroditism (HP:0010459)2.05814477
101Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05459356
102Increased hepatocellular lipid droplets (HP:0006565)2.05232972
103Recurrent bronchitis (HP:0002837)2.05199222
104Nasal polyposis (HP:0100582)2.03952313
105Cerebral edema (HP:0002181)2.03026142
106Increased muscle lipid content (HP:0009058)2.02416785
107Pancreatic fibrosis (HP:0100732)2.01264070
108Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99243333
109Progressive cerebellar ataxia (HP:0002073)1.98750755
110Abnormal number of erythroid precursors (HP:0012131)1.97283642
111Increased intramyocellular lipid droplets (HP:0012240)1.96596607
112Optic nerve hypoplasia (HP:0000609)1.95984237
113Broad-based gait (HP:0002136)1.95740101
114Tachypnea (HP:0002789)1.94551701
115Hypothermia (HP:0002045)1.93813534
116Hypomagnesemia (HP:0002917)1.93588638
117Exercise-induced muscle cramps (HP:0003710)1.93336204
118Bronchiectasis (HP:0002110)1.91605438
119Exercise intolerance (HP:0003546)1.91466711
120Decreased central vision (HP:0007663)1.91463135
121Poor speech (HP:0002465)1.90801001
122Methylmalonic acidemia (HP:0002912)1.89464020
123Gaze-evoked nystagmus (HP:0000640)1.87274114
124Aplasia/hypoplasia of the uterus (HP:0008684)1.86940882
125Myositis (HP:0100614)1.86470870
126Congenital sensorineural hearing impairment (HP:0008527)1.86078973
127Severe muscular hypotonia (HP:0006829)1.85942600
128Molar tooth sign on MRI (HP:0002419)1.85039784
129Abnormality of midbrain morphology (HP:0002418)1.85039784
130Patellar aplasia (HP:0006443)1.84837022
131Postaxial foot polydactyly (HP:0001830)1.84800091
132Bony spicule pigmentary retinopathy (HP:0007737)1.84405685
133Aplasia/Hypoplasia of the patella (HP:0006498)1.84375125
134Abnormal hair whorl (HP:0010721)1.83702547
135Visual hallucinations (HP:0002367)1.83422901
136Self-mutilation (HP:0000742)1.82253494
137Fetal akinesia sequence (HP:0001989)1.81623042
138Abnormality of pain sensation (HP:0010832)1.80982102
139Impaired pain sensation (HP:0007328)1.80982102
140Increased serum lactate (HP:0002151)1.79220554
141Chorioretinal atrophy (HP:0000533)1.78916222
142Abnormal urine output (HP:0012590)1.78730913
143Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.78066399
144Ketosis (HP:0001946)1.77959887
145Aplasia/Hypoplasia of the lens (HP:0008063)1.77588946
146Ketoacidosis (HP:0001993)1.77204253
147Intestinal atresia (HP:0011100)1.76309103
148Asymmetric septal hypertrophy (HP:0001670)1.76254485
149Absence seizures (HP:0002121)1.76185253
150IgM deficiency (HP:0002850)1.73566613
151Methylmalonic aciduria (HP:0012120)1.73212974
152Genital tract atresia (HP:0001827)1.72762598
153Polyphagia (HP:0002591)1.72515791
154Limb dystonia (HP:0002451)1.72284072
155Postaxial hand polydactyly (HP:0001162)1.71891263
156Calf muscle hypertrophy (HP:0008981)1.70693015
157Abnormality of the lower motor neuron (HP:0002366)1.70506672
158Anophthalmia (HP:0000528)1.69907903
159Rhabdomyolysis (HP:0003201)1.69894534
160Dandy-Walker malformation (HP:0001305)1.69814810
161Stomach cancer (HP:0012126)1.68823180
162Vaginal atresia (HP:0000148)1.68589616
163Cholelithiasis (HP:0001081)1.68527659
164Progressive microcephaly (HP:0000253)1.68228506
165Recurrent otitis media (HP:0000403)1.66686062
166Abnormality of the vocal cords (HP:0008777)1.66510386
167Thrombocytosis (HP:0001894)1.64833916
168Dysmetric saccades (HP:0000641)1.62171042

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.19294207
2SIK23.81694723
3CASK3.80278421
4BMPR1B3.62909907
5PDK43.47780146
6PDK33.47780146
7MAP2K73.24644063
8ERBB32.96805967
9BMPR22.93820450
10WNK42.89111929
11MAP3K42.88711993
12ZAK2.83636961
13GRK12.77801219
14WNK32.73239875
15CAMKK22.65697492
16MAP3K122.40762550
17CCNB12.36506978
18CDK192.30791470
19BCKDK2.30521844
20MAP4K22.15997009
21TESK12.14433729
22NUAK12.09807397
23PNCK2.07692844
24SIK31.89243315
25STK161.83053735
26MAPK131.70499929
27PDK21.63959067
28DAPK11.63752162
29OXSR11.61332328
30STK391.59032093
31SGK21.53374334
32KIT1.50193229
33MUSK1.36820611
34ACVR1B1.36358323
35MAP2K41.33363484
36DYRK21.32660843
37FLT31.32634533
38PRPF4B1.30919560
39ZAP701.30212415
40BRAF1.30160573
41NTRK31.29478984
42MYLK1.29138542
43OBSCN1.24433997
44IRAK21.23250521
45TIE11.22878100
46PHKG21.20823259
47PHKG11.20823259
48MAP2K61.19235048
49SGK2231.13265174
50SGK4941.13265174
51PKN21.10995059
52BLK1.09952654
53ADRBK11.09817466
54DAPK21.07670494
55SGK31.07036368
56CAMK11.05563146
57PAK31.05513006
58MARK11.04493456
59TXK1.03913933
60MKNK21.01930397
61TSSK61.00872137
62TGFBR11.00700631
63NEK90.98735890
64NEK10.97359182
65ARAF0.94718839
66STK380.94219812
67PRKCE0.93102389
68SYK0.89946068
69WEE10.86163843
70SRPK10.85994781
71ADRBK20.85551240
72MAPKAPK50.85075012
73PTK2B0.81324214
74MAPK150.81157520
75RPS6KA50.78980046
76CAMKK10.78928842
77DYRK1A0.77771446
78TLK10.74750294
79PLK20.74493336
80PLK30.74359078
81PRKD30.73602114
82TRIM280.72221994
83PIK3CA0.72192092
84PRKCI0.71993454
85IKBKB0.68775409
86PRKCQ0.68251431
87CSNK1G20.68036004
88TAF10.67618290
89CSNK1G10.67449047
90AKT30.66920676
91PRKCG0.66859747
92MAP3K70.65684293
93CAMK40.65480010
94PINK10.65306964
95IRAK10.65063942
96MINK10.64331362
97CAMK2A0.63286411
98BUB10.61843930
99CSNK1G30.61382769
100EPHA30.58508053
101CDK80.58407764
102TNIK0.57173477
103CAMK2D0.56652679
104MARK20.56407654
105NME10.56368105
106NLK0.53837780
107PRKACA0.53604429
108TTN0.53289198
109NTRK20.52115919
110DYRK30.51525727
111MAP3K100.51062635
112TEC0.50673999
113PKN10.50640030
114FES0.50544001
115BTK0.50483585
116ITK0.50026436
117MAP4K10.49998311
118DAPK30.49846094
119KDR0.49345287
120PASK0.49084212
121PLK40.48657280
122CHUK0.48642160
123TAOK30.47919974
124MAP2K20.47241947
125NEK20.45788883
126MKNK10.45581454
127EPHA40.44929828
128PRKAA10.44627762
129CAMK2G0.44248227
130CDK50.43883143
131EIF2AK30.41202374
132SCYL20.40752875
133MAP3K20.40551604
134INSRR0.39987231
135DYRK1B0.39890572
136RPS6KA60.39604454
137GRK60.38769133
138MAPK120.38684849
139STK110.37918929
140CAMK2B0.36696325
141FGFR20.36263584
142CSNK1A10.36249596
143PRKCA0.35488502
144CSNK1A1L0.35347365
145PRKCH0.34262840
146PRKG10.34006192
147TNK20.33091808
148VRK20.32325332
149ILK0.31974754
150PRKCZ0.31898427
151CSNK1D0.31878587
152WNK10.31460991
153CSF1R0.30970741
154EPHB20.30783267
155CDK30.30411241
156BCR0.30400604
157TGFBR20.29655896
158PDK10.28659909
159VRK10.27134950
160MAPKAPK30.26036021

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.58980667
2Olfactory transduction_Homo sapiens_hsa047403.61196724
3Synaptic vesicle cycle_Homo sapiens_hsa047213.36048443
4Collecting duct acid secretion_Homo sapiens_hsa049663.31881926
5Selenocompound metabolism_Homo sapiens_hsa004502.82833237
6Linoleic acid metabolism_Homo sapiens_hsa005912.61674916
7Pyruvate metabolism_Homo sapiens_hsa006202.58626386
8Oxidative phosphorylation_Homo sapiens_hsa001902.51564668
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.46837368
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.43564677
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.42699043
12Nitrogen metabolism_Homo sapiens_hsa009102.39383729
13Vibrio cholerae infection_Homo sapiens_hsa051102.24559728
14Parkinsons disease_Homo sapiens_hsa050122.21609674
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.17935254
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.16032087
17Insulin secretion_Homo sapiens_hsa049112.05843829
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.01534672
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.91985433
20Other glycan degradation_Homo sapiens_hsa005111.89353067
21Basal transcription factors_Homo sapiens_hsa030221.83729323
22Carbon metabolism_Homo sapiens_hsa012001.83588790
23Protein export_Homo sapiens_hsa030601.83460555
24Tryptophan metabolism_Homo sapiens_hsa003801.82709619
25Homologous recombination_Homo sapiens_hsa034401.80559703
26Propanoate metabolism_Homo sapiens_hsa006401.77636894
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.76768862
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.76713410
29Caffeine metabolism_Homo sapiens_hsa002321.74773740
30Amphetamine addiction_Homo sapiens_hsa050311.74637854
31Nicotine addiction_Homo sapiens_hsa050331.71262586
32Morphine addiction_Homo sapiens_hsa050321.70109645
33Alzheimers disease_Homo sapiens_hsa050101.66895218
34Circadian entrainment_Homo sapiens_hsa047131.66095473
35Ether lipid metabolism_Homo sapiens_hsa005651.65518111
36GABAergic synapse_Homo sapiens_hsa047271.61534254
37Cardiac muscle contraction_Homo sapiens_hsa042601.56547943
38Huntingtons disease_Homo sapiens_hsa050161.56416429
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47921925
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.41630935
41Biosynthesis of amino acids_Homo sapiens_hsa012301.36858878
42Fanconi anemia pathway_Homo sapiens_hsa034601.31115004
43Glucagon signaling pathway_Homo sapiens_hsa049221.28753449
44Fatty acid degradation_Homo sapiens_hsa000711.25632411
45Dopaminergic synapse_Homo sapiens_hsa047281.24791972
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22840011
47Pentose phosphate pathway_Homo sapiens_hsa000301.22006760
48Ribosome_Homo sapiens_hsa030101.19492494
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.16248128
50RNA degradation_Homo sapiens_hsa030181.14657264
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14277173
52Sulfur metabolism_Homo sapiens_hsa009201.14226312
53ABC transporters_Homo sapiens_hsa020101.11061627
54Long-term potentiation_Homo sapiens_hsa047201.10144290
55Phototransduction_Homo sapiens_hsa047441.09844336
56Chemical carcinogenesis_Homo sapiens_hsa052041.08668215
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.07512435
58Maturity onset diabetes of the young_Homo sapiens_hsa049501.07352140
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06560027
60One carbon pool by folate_Homo sapiens_hsa006701.06051562
61Arachidonic acid metabolism_Homo sapiens_hsa005901.05692263
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02006075
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02002689
64Steroid hormone biosynthesis_Homo sapiens_hsa001401.01768240
65Cocaine addiction_Homo sapiens_hsa050300.99951504
66Calcium signaling pathway_Homo sapiens_hsa040200.99346183
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98725425
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97960663
69Glutamatergic synapse_Homo sapiens_hsa047240.97806240
70Type I diabetes mellitus_Homo sapiens_hsa049400.97800684
71Renin secretion_Homo sapiens_hsa049240.94756795
72Fatty acid biosynthesis_Homo sapiens_hsa000610.91919723
73Regulation of autophagy_Homo sapiens_hsa041400.91510237
74Retinol metabolism_Homo sapiens_hsa008300.89143638
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89099495
76Fatty acid metabolism_Homo sapiens_hsa012120.88004267
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87967673
78Circadian rhythm_Homo sapiens_hsa047100.87651453
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86432845
80Purine metabolism_Homo sapiens_hsa002300.86055743
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86029088
82Galactose metabolism_Homo sapiens_hsa000520.85057608
83Peroxisome_Homo sapiens_hsa041460.84467479
84Fructose and mannose metabolism_Homo sapiens_hsa000510.84443333
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84424857
86Rheumatoid arthritis_Homo sapiens_hsa053230.83604671
87Serotonergic synapse_Homo sapiens_hsa047260.81628172
88Asthma_Homo sapiens_hsa053100.79599328
89Cholinergic synapse_Homo sapiens_hsa047250.76774294
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76602748
91Oxytocin signaling pathway_Homo sapiens_hsa049210.76353516
92cAMP signaling pathway_Homo sapiens_hsa040240.75674496
93Ovarian steroidogenesis_Homo sapiens_hsa049130.75384279
94Alcoholism_Homo sapiens_hsa050340.74048760
95Mineral absorption_Homo sapiens_hsa049780.73528383
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73414059
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70732625
98Sulfur relay system_Homo sapiens_hsa041220.70214250
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.68609821
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68531413
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68520505
102Phagosome_Homo sapiens_hsa041450.68331928
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68018157
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67817261
105Fat digestion and absorption_Homo sapiens_hsa049750.67651383
106Dilated cardiomyopathy_Homo sapiens_hsa054140.64762800
107Salivary secretion_Homo sapiens_hsa049700.63046238
108Taste transduction_Homo sapiens_hsa047420.62204430
109Steroid biosynthesis_Homo sapiens_hsa001000.61601840
110Proteasome_Homo sapiens_hsa030500.60615414
111N-Glycan biosynthesis_Homo sapiens_hsa005100.60059597
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57807905
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57474423
114Glycerolipid metabolism_Homo sapiens_hsa005610.57245498
115Gastric acid secretion_Homo sapiens_hsa049710.56478991
116RNA polymerase_Homo sapiens_hsa030200.55848444
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55417593
118Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54954938
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54941576
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53766527
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53621703
122Butanoate metabolism_Homo sapiens_hsa006500.53053436
123Primary immunodeficiency_Homo sapiens_hsa053400.50329454
124Basal cell carcinoma_Homo sapiens_hsa052170.49066540
125Metabolic pathways_Homo sapiens_hsa011000.46923061
126Hedgehog signaling pathway_Homo sapiens_hsa043400.46332204
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44852059
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44828677
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44363563
130Histidine metabolism_Homo sapiens_hsa003400.43420625
131Dorso-ventral axis formation_Homo sapiens_hsa043200.40132400
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40022758
133Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38398415
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33993309
135Legionellosis_Homo sapiens_hsa051340.33049783
136Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32644618
137Tuberculosis_Homo sapiens_hsa051520.32546476
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32390562
139Oocyte meiosis_Homo sapiens_hsa041140.29476278
140Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29041518
141Graft-versus-host disease_Homo sapiens_hsa053320.27333675
142Pyrimidine metabolism_Homo sapiens_hsa002400.26441838
143beta-Alanine metabolism_Homo sapiens_hsa004100.21796149
144Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21681993
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.20650503
146Lysosome_Homo sapiens_hsa041420.20242141
147Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19113883
148Thyroid hormone synthesis_Homo sapiens_hsa049180.17943751
149Gap junction_Homo sapiens_hsa045400.17866068

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