DAB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.38003341
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.38003341
3positive regulation by organism of defense response of other organism involved in symbiotic interact7.38003341
4modulation by symbiont of host immune response (GO:0052553)7.38003341
5positive regulation by symbiont of host defense response (GO:0052509)7.38003341
6modulation by symbiont of host defense response (GO:0052031)7.38003341
7regulation of interferon-beta biosynthetic process (GO:0045357)6.30429813
8macrophage activation involved in immune response (GO:0002281)5.24295419
9positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.10152777
10positive regulation of interferon-alpha production (GO:0032727)5.02527206
11neutrophil activation involved in immune response (GO:0002283)4.81602826
12regulation of interferon-alpha production (GO:0032647)4.80828486
13microglial cell activation (GO:0001774)4.67780685
14response to host immune response (GO:0052572)4.60588326
15response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.60588326
16virion attachment to host cell (GO:0019062)4.51620720
17adhesion of symbiont to host cell (GO:0044650)4.51620720
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.49103436
19extracellular fibril organization (GO:0043206)4.48330122
20barbed-end actin filament capping (GO:0051016)4.33895446
21response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.19823345
22response to host (GO:0075136)4.19823345
23response to host defenses (GO:0052200)4.19823345
24collagen fibril organization (GO:0030199)4.19080654
25cell migration involved in heart development (GO:0060973)4.12336392
26response to peptidoglycan (GO:0032494)4.10336192
27fibril organization (GO:0097435)4.07944948
28immunoglobulin mediated immune response (GO:0016064)4.05182298
29regulation of mononuclear cell migration (GO:0071675)4.03344150
30macrophage activation (GO:0042116)3.96490096
31endodermal cell differentiation (GO:0035987)3.88165140
32regulation of cholesterol storage (GO:0010885)3.81311254
33detection of molecule of bacterial origin (GO:0032490)3.68476136
34stress fiber assembly (GO:0043149)3.64614823
35apoptotic cell clearance (GO:0043277)3.62268948
36* regulation of integrin-mediated signaling pathway (GO:2001044)3.61936726
37substrate-dependent cell migration (GO:0006929)3.61358849
38blood vessel maturation (GO:0001955)3.54836248
39sequestering of extracellular ligand from receptor (GO:0035581)3.53443718
40negative regulation of smooth muscle cell migration (GO:0014912)3.51053869
41I-kappaB phosphorylation (GO:0007252)3.46641979
42protein localization to endosome (GO:0036010)3.46636485
43chondrocyte proliferation (GO:0035988)3.43218733
44positive regulation of interferon-beta production (GO:0032728)3.40485886
45positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.40399608
46skin morphogenesis (GO:0043589)3.40181297
47eosinophil chemotaxis (GO:0048245)3.38110129
48regulation of interleukin-8 biosynthetic process (GO:0045414)3.36227629
49low-density lipoprotein particle clearance (GO:0034383)3.32401192
50protein heterotrimerization (GO:0070208)3.32286253
51positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.30854780
52negative regulation of nitric-oxide synthase activity (GO:0051001)3.29417139
53cellular response to interferon-alpha (GO:0035457)3.28496242
54cell adhesion mediated by integrin (GO:0033627)3.26908021
55vascular endothelial growth factor signaling pathway (GO:0038084)3.26440625
56retina vasculature morphogenesis in camera-type eye (GO:0061299)3.25681571
57positive regulation of macrophage cytokine production (GO:0060907)3.24195582
58regulation of B cell receptor signaling pathway (GO:0050855)3.20712576
59myeloid cell activation involved in immune response (GO:0002275)3.20103002
60production of molecular mediator involved in inflammatory response (GO:0002532)3.18238574
61positive regulation of endothelial cell apoptotic process (GO:2000353)3.17414764
62positive regulation of cellular amide metabolic process (GO:0034250)3.17301302
63response to magnesium ion (GO:0032026)3.17171887
64toxin transport (GO:1901998)3.13050294
65venous blood vessel morphogenesis (GO:0048845)3.12678759
66collagen metabolic process (GO:0032963)3.12131381
67lipopolysaccharide-mediated signaling pathway (GO:0031663)3.11859669
68positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.10141047
69negative regulation of granulocyte differentiation (GO:0030853)3.09525803
70positive regulation of antigen processing and presentation (GO:0002579)3.09338127
71monocyte chemotaxis (GO:0002548)3.04532461
72phagocytosis, engulfment (GO:0006911)3.02456650
73negative regulation of platelet activation (GO:0010544)3.02067636
74extracellular matrix assembly (GO:0085029)3.01875023
75negative regulation of mast cell activation (GO:0033004)3.01636051
76negative regulation of nitric oxide biosynthetic process (GO:0045019)3.00896743
77collagen catabolic process (GO:0030574)2.99904054
78respiratory burst (GO:0045730)2.99406960
79regulation of macrophage chemotaxis (GO:0010758)2.94495298
80* pinocytosis (GO:0006907)2.94415953
81platelet degranulation (GO:0002576)2.94150251
82kidney mesenchyme development (GO:0072074)2.94099137
83substrate adhesion-dependent cell spreading (GO:0034446)2.93946243
84cellular extravasation (GO:0045123)2.91989233
85positive regulation of extracellular matrix organization (GO:1903055)2.91598159
86hyaluronan catabolic process (GO:0030214)2.91158259
87eosinophil migration (GO:0072677)2.90664571
88regulation of mast cell degranulation (GO:0043304)2.90135169
89multicellular organismal macromolecule metabolic process (GO:0044259)2.89024080
90positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.88697781
91regulation of macrophage cytokine production (GO:0010935)2.87655435
92wound healing, spreading of epidermal cells (GO:0035313)2.87086551
93granulocyte activation (GO:0036230)2.87001816
94type B pancreatic cell proliferation (GO:0044342)2.86558189
95keratan sulfate catabolic process (GO:0042340)2.85028853
96negative regulation of lipid storage (GO:0010888)2.84735583
97metanephric mesenchyme development (GO:0072075)2.84533928
98positive regulation of chemokine biosynthetic process (GO:0045080)2.84288272
99positive regulation of p38MAPK cascade (GO:1900745)2.83995698
100endothelium development (GO:0003158)2.82720236
101B cell mediated immunity (GO:0019724)2.81975759
102negative regulation of homotypic cell-cell adhesion (GO:0034111)2.80036040
103regulation of mast cell activation involved in immune response (GO:0033006)2.79489657
104positive regulation of leukocyte degranulation (GO:0043302)2.79403423
105multicellular organismal catabolic process (GO:0044243)2.79154686
106folic acid transport (GO:0015884)2.78972679
107melanin biosynthetic process (GO:0042438)2.78932766
108response to muramyl dipeptide (GO:0032495)2.77360609
109lymphocyte chemotaxis (GO:0048247)2.76185826
110multicellular organismal metabolic process (GO:0044236)2.75466500
111response to thyroid hormone (GO:0097066)2.75387978
112neutrophil activation (GO:0042119)2.75298404
113negative regulation of focal adhesion assembly (GO:0051895)2.75234607
114negative regulation of cell junction assembly (GO:1901889)2.75234607
115negative regulation of adherens junction organization (GO:1903392)2.75234607
116extracellular matrix disassembly (GO:0022617)2.74890898
117positive regulation of mast cell activation (GO:0033005)2.74060183
118cellular response to vitamin (GO:0071295)2.73371555
119lipoprotein transport (GO:0042953)2.71296058
120regulation of chemokine-mediated signaling pathway (GO:0070099)2.71128665
121angiogenesis involved in wound healing (GO:0060055)2.69704536
122vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.69296597
123platelet aggregation (GO:0070527)2.69080138
124regulation of monocyte chemotaxis (GO:0090025)2.68996428
125glycosphingolipid catabolic process (GO:0046479)2.68851148
126regulation of dendritic cell antigen processing and presentation (GO:0002604)2.68729433
127positive regulation of fibroblast migration (GO:0010763)2.67642759
128regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.67401631
129regulation of leukocyte degranulation (GO:0043300)2.67296113
130pericardium development (GO:0060039)2.65977816
131cellular response to thyroid hormone stimulus (GO:0097067)2.65596973
132mannose metabolic process (GO:0006013)2.65484234
133regulation of extracellular matrix disassembly (GO:0010715)2.64813417
134positive regulation of bone remodeling (GO:0046852)2.64631975
135positive regulation of bone resorption (GO:0045780)2.64631975
136membrane raft organization (GO:0031579)2.64296987
137glomerular basement membrane development (GO:0032836)2.64104902
138regulation of membrane protein ectodomain proteolysis (GO:0051043)2.62303906
139positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.61463644
140positive regulation of monocyte chemotaxis (GO:0090026)2.61042687
141positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.60032110
142mesenchymal-epithelial cell signaling (GO:0060638)2.59760299
143response to interferon-alpha (GO:0035455)2.59651206
144regulation of integrin activation (GO:0033623)2.58551364
145regulation of mast cell activation (GO:0033003)2.58335699
146regulation of antigen processing and presentation (GO:0002577)2.57929335
147regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.57875424
148phagocytosis, recognition (GO:0006910)2.56858229
149positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.56846172
150regulation of smooth muscle cell migration (GO:0014910)2.56456093
151response to laminar fluid shear stress (GO:0034616)2.56161268
152positive regulation of osteoblast proliferation (GO:0033690)2.56044931
153regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.55398480
154bone trabecula formation (GO:0060346)2.54886893
155positive regulation of smooth muscle cell migration (GO:0014911)2.53953937
156positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.53823928
157regulation of interferon-beta production (GO:0032648)2.52825680
158basement membrane organization (GO:0071711)2.52079923
159membrane invagination (GO:0010324)2.51287861
160endothelial cell morphogenesis (GO:0001886)2.50948594
161positive regulation of blood vessel endothelial cell migration (GO:0043536)2.50510446
162tooth mineralization (GO:0034505)2.50491412
163positive regulation of chemokine production (GO:0032722)2.50167898
164negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.50063018
165positive regulation of T cell apoptotic process (GO:0070234)2.50061560
166regulation of platelet activation (GO:0010543)2.50017084
167adhesion of symbiont to host (GO:0044406)2.49678552
168cortical actin cytoskeleton organization (GO:0030866)2.48943827
169positive regulation of lymphocyte migration (GO:2000403)2.48927726
170lymphangiogenesis (GO:0001946)2.48245228
171negative regulation of protein localization to cell surface (GO:2000009)2.47906726
172negative regulation of monooxygenase activity (GO:0032769)2.44644272
173protein localization to cell surface (GO:0034394)2.43986777
174extracellular matrix organization (GO:0030198)2.43822417
175extracellular structure organization (GO:0043062)2.42823184
176* negative regulation of protein localization to plasma membrane (GO:1903077)2.42200802
177hypotonic response (GO:0006971)2.42030132
178extracellular regulation of signal transduction (GO:1900115)2.39863627
179extracellular negative regulation of signal transduction (GO:1900116)2.39863627
180melanin metabolic process (GO:0006582)2.39652554
181endosome to melanosome transport (GO:0035646)2.37499393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.10918439
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.09465080
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.50409514
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.45146506
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.18364445
6* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.01316525
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.65210638
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.15134223
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.89753525
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.74173566
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.69963706
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.68325288
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.56729832
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.49703345
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.38890598
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.38850879
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.31540549
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.28868095
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.24583190
20PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.15827397
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.15065119
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.11988043
23* ESR1_21235772_ChIP-Seq_MCF-7_Human2.11818377
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02772537
25VDR_24787735_ChIP-Seq_THP-1_Human1.97926859
26* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.96150131
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87875183
28EP300_21415370_ChIP-Seq_HL-1_Mouse1.81459328
29SPI1_23127762_ChIP-Seq_K562_Human1.80670892
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.80322395
31SPI1_23547873_ChIP-Seq_NB4_Human1.78397918
32* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.78101253
33* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.75556281
34* PU_27001747_Chip-Seq_BMDM_Mouse1.74230884
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73730855
36* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.67450824
37* GATA2_21666600_ChIP-Seq_HMVEC_Human1.66576965
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60454701
39* CLOCK_20551151_ChIP-Seq_293T_Human1.60067516
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59103554
41VDR_24763502_ChIP-Seq_THP-1_Human1.49117866
42* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48700506
43CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47563311
44CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42986661
45CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42219245
46TP53_18474530_ChIP-ChIP_U2OS_Human1.40453207
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38001116
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.37609161
49* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37314660
50SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37268484
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36320254
52* CJUN_26792858_Chip-Seq_BT549_Human1.35847610
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34485432
54TBX20_22328084_ChIP-Seq_HEART_Mouse1.33100702
55TBX20_22080862_ChIP-Seq_HEART_Mouse1.33100702
56NFIB_24661679_ChIP-Seq_LUNG_Mouse1.32979306
57TP53_16413492_ChIP-PET_HCT116_Human1.32527737
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31805311
59* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.30493736
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.30003656
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.28830555
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28670662
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.27733541
64TFEB_21752829_ChIP-Seq_HELA_Human1.27527540
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26239256
66* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26019666
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24138524
68PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.23338758
69* GATA1_19941826_ChIP-Seq_K562_Human1.22016510
70CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21746906
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20832429
72LXR_22158963_ChIP-Seq_LIVER_Mouse1.20305046
73* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19630222
74SCL_19346495_ChIP-Seq_HPC-7_Human1.19619638
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19522254
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15379458
77* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15093163
78VDR_21846776_ChIP-Seq_THP-1_Human1.14732307
79SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14726598
80SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14726598
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13630102
82RUNX_20019798_ChIP-Seq_JUKART_Human1.13267356
83MAF_26560356_Chip-Seq_TH1_Human1.09678613
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09646935
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09646935
86RXR_22158963_ChIP-Seq_LIVER_Mouse1.09478898
87* SOX2_20726797_ChIP-Seq_SW620_Human1.07434657
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06907343
89UBF1/2_26484160_Chip-Seq_HMECs_Human1.06459523
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05306468
91WT1_19549856_ChIP-ChIP_CCG9911_Human1.04949916
92JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04916910
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04303287
94* SA1_22415368_ChIP-Seq_MEFs_Mouse1.03812209
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02479042
96GATA1_22025678_ChIP-Seq_K562_Human1.02356100
97* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02119748
98* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01951926
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01283532
100PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01106169
101GATA2_19941826_ChIP-Seq_K562_Human1.01004463
102PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.99905439
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99796304
104CDX2_20551321_ChIP-Seq_CACO-2_Human0.99551371
105JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99538419
106* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99461296
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98465547
108ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.98151936
109SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97577867
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97484612
111SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97158121
112MYB_26560356_Chip-Seq_TH2_Human0.96287007
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95941035
114CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94703032
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94596919
116MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93861042
117MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92247405
118* TP63_23658742_ChIP-Seq_EP156T_Human0.91683422
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91258517
120* AHR_22903824_ChIP-Seq_MCF-7_Human0.90931032
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90485205
122SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89920098
123FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89130424
124KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88462379
125TP53_23651856_ChIP-Seq_MEFs_Mouse0.88066024
126* BRD4_25478319_ChIP-Seq_HGPS_Human0.87102970
127E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87060465
128ESR1_20079471_ChIP-ChIP_T-47D_Human0.86384162
129LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.85827899
130EGR1_19032775_ChIP-ChIP_M12_Human0.85658708
131ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.85271203
132TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84625418
133GATA3_26560356_Chip-Seq_TH2_Human0.83802016
134P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83614572
135TP53_22127205_ChIP-Seq_IMR90_Human0.83567775
136SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.81645211
137KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.80801334
138SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80637634
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.79679647

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.15440470
2MP0009840_abnormal_foam_cell3.38027975
3MP0008438_abnormal_cutaneous_collagen3.29277350
4MP0000569_abnormal_digit_pigmentation2.91852728
5MP0003950_abnormal_plasma_membrane2.89541671
6MP0003303_peritoneal_inflammation2.88923999
7MP0003436_decreased_susceptibility_to2.86983857
8MP0001835_abnormal_antigen_presentation2.81558433
9MP0003172_abnormal_lysosome_physiology2.79458246
10MP0002419_abnormal_innate_immunity2.51320012
11MP0006082_CNS_inflammation2.48780174
12MP0003300_gastrointestinal_ulcer2.43199624
13MP0003705_abnormal_hypodermis_morpholog2.36632238
14MP0005171_absent_coat_pigmentation2.29470679
15MP0002148_abnormal_hypersensitivity_rea2.21859635
16MP0003191_abnormal_cellular_cholesterol2.20932739
17MP0002877_abnormal_melanocyte_morpholog2.10172939
18MP0000343_altered_response_to2.09273784
19MP0001533_abnormal_skeleton_physiology2.00907010
20MP0005000_abnormal_immune_tolerance1.99078151
21MP0001958_emphysema1.97395967
22MP0003724_increased_susceptibility_to1.88070659
23MP0003690_abnormal_glial_cell1.75194165
24MP0009384_cardiac_valve_regurgitation1.74123188
25MP0008004_abnormal_stomach_pH1.73779576
26MP0000604_amyloidosis1.72996739
27MP0002452_abnormal_antigen_presenting1.72345539
28MP0003566_abnormal_cell_adhesion1.72118439
29MP0003448_altered_tumor_morphology1.67674909
30MP0005025_abnormal_response_to1.65683641
31MP0005387_immune_system_phenotype1.64012068
32MP0001790_abnormal_immune_system1.64012068
33MP0005257_abnormal_intraocular_pressure1.63747785
34MP0009278_abnormal_bone_marrow1.63014425
35MP0009785_altered_susceptibility_to1.62203913
36MP0004510_myositis1.59630977
37MP0003828_pulmonary_edema1.57039132
38MP0002998_abnormal_bone_remodeling1.55499106
39MP0004019_abnormal_vitamin_homeostasis1.55383111
40MP0005464_abnormal_platelet_physiology1.50689885
41MP0002896_abnormal_bone_mineralization1.49143797
42MP0005275_abnormal_skin_tensile1.44274748
43MP0003279_aneurysm1.44176796
44MP0005595_abnormal_vascular_smooth1.44111845
45MP0005623_abnormal_meninges_morphology1.43391285
46MP0005508_abnormal_skeleton_morphology1.42474387
47MP0000372_irregular_coat_pigmentation1.42220534
48MP0002723_abnormal_immune_serum1.39163364
49MP0005408_hypopigmentation1.38879293
50MP0000015_abnormal_ear_pigmentation1.36165646
51MP0004272_abnormal_basement_membrane1.35562788
52MP0001800_abnormal_humoral_immune1.32698444
53MP0008469_abnormal_protein_level1.30421447
54MP0002405_respiratory_system_inflammati1.29418286
55MP0001845_abnormal_inflammatory_respons1.28088797
56MP0009764_decreased_sensitivity_to1.25364086
57MP0001819_abnormal_immune_cell1.21879186
58* MP0002136_abnormal_kidney_physiology1.21836197
59MP0004947_skin_inflammation1.20551932
60MP0002420_abnormal_adaptive_immunity1.19774401
61MP0010386_abnormal_urinary_bladder1.18732265
62MP0003075_altered_response_to1.18556181
63MP0001853_heart_inflammation1.18125146
64MP0001756_abnormal_urination1.18073201
65MP0005390_skeleton_phenotype1.17604037
66MP0005167_abnormal_blood-brain_barrier1.14529827
67MP0002060_abnormal_skin_morphology1.13737661
68MP0000767_abnormal_smooth_muscle1.12988275
69MP0005164_abnormal_response_to1.12300232
70MP0005310_abnormal_salivary_gland1.11454991
71MP0010352_gastrointestinal_tract_polyps1.10919198
72MP0002138_abnormal_hepatobiliary_system1.10204147
73MP0005076_abnormal_cell_differentiation1.09431913
74MP0003195_calcinosis1.08086973
75MP0003091_abnormal_cell_migration1.07085819
76MP0005023_abnormal_wound_healing1.06680820
77MP0010307_abnormal_tumor_latency1.05925918
78MP0006054_spinal_hemorrhage1.05542721
79MP0005409_darkened_coat_color1.03745704
80MP0002254_reproductive_system_inflammat1.02767318
81MP0010368_abnormal_lymphatic_system1.02571888
82MP0005166_decreased_susceptibility_to1.02203809
83* MP0009643_abnormal_urine_homeostasis1.02159357
84MP0001243_abnormal_dermal_layer1.00907964
85MP0002933_joint_inflammation1.00816873
86MP0002295_abnormal_pulmonary_circulatio0.98842304
87MP0001915_intracranial_hemorrhage0.98592270
88MP0003795_abnormal_bone_structure0.98531494
89MP0002108_abnormal_muscle_morphology0.98512080
90MP0004084_abnormal_cardiac_muscle0.98318523
91MP0003941_abnormal_skin_development0.98161558
92MP0000685_abnormal_immune_system0.96744266
93MP0000858_altered_metastatic_potential0.94862887
94MP0005503_abnormal_tendon_morphology0.94276463
95MP0005671_abnormal_response_to0.94019484
96MP0002128_abnormal_blood_circulation0.93996652
97MP0009333_abnormal_splenocyte_physiolog0.92769711
98MP0004233_abnormal_muscle_weight0.92613866
99MP0004883_abnormal_blood_vessel0.92479710
100MP0001851_eye_inflammation0.90225597
101MP0000751_myopathy0.87044699
102MP0000013_abnormal_adipose_tissue0.86212049
103MP0000249_abnormal_blood_vessel0.86048962
104MP0001849_ear_inflammation0.85524325
105* MP0002135_abnormal_kidney_morphology0.85089167
106MP0000689_abnormal_spleen_morphology0.84160591
107MP0002168_other_aberrant_phenotype0.83358956
108MP0000749_muscle_degeneration0.83061924
109MP0000465_gastrointestinal_hemorrhage0.82809862
110MP0009780_abnormal_chondrocyte_physiolo0.82437283
111MP0005174_abnormal_tail_pigmentation0.82059306
112MP0010155_abnormal_intestine_physiology0.81671023
113MP0003186_abnormal_redox_activity0.81392305
114MP0000371_diluted_coat_color0.80370448
115MP0006138_congestive_heart_failure0.79853637
116MP0004036_abnormal_muscle_relaxation0.79587029
117MP0001881_abnormal_mammary_gland0.78687949
118MP0001879_abnormal_lymphatic_vessel0.78056313
119MP0003183_abnormal_peptide_metabolism0.77857568
120MP0005197_abnormal_uvea_morphology0.76485154
121MP0005397_hematopoietic_system_phenotyp0.75485921
122MP0001545_abnormal_hematopoietic_system0.75485921
123MP0005165_increased_susceptibility_to0.73467205
124MP0000716_abnormal_immune_system0.73434277
125MP0001614_abnormal_blood_vessel0.73158043
126MP0000733_abnormal_muscle_development0.72907370
127MP0009763_increased_sensitivity_to0.72583950
128MP0001542_abnormal_bone_strength0.72269891
129MP0002113_abnormal_skeleton_development0.72255619
130MP0005332_abnormal_amino_acid0.72178056
131MP0002115_abnormal_skeleton_extremities0.71458174
132MP0009250_abnormal_appendicular_skeleto0.71201911
133MP0000163_abnormal_cartilage_morphology0.70379062
134MP0002133_abnormal_respiratory_system0.69892910
135MP0005388_respiratory_system_phenotype0.69892910
136MP0005193_abnormal_anterior_eye0.68115636
137MP0000230_abnormal_systemic_arterial0.66072694
138MP0000534_abnormal_ureter_morphology0.65713015
139MP0000759_abnormal_skeletal_muscle0.65537129
140MP0001299_abnormal_eye_distance/0.58441981
141MP0010030_abnormal_orbit_morphology0.54503271
142MP0000003_abnormal_adipose_tissue0.53281082

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.28599667
2Vacuolated lymphocytes (HP:0001922)6.06233387
3Increased cerebral lipofuscin (HP:0011813)5.78893041
4Recurrent abscess formation (HP:0002722)5.32065782
5Increased neuronal autofluorescent lipopigment (HP:0002074)5.18722429
6Recurrent bacterial skin infections (HP:0005406)4.67725176
7Dysostosis multiplex (HP:0000943)4.56517761
8Axonal loss (HP:0003447)4.42109366
9Glomerulonephritis (HP:0000099)4.35191909
10Eczematoid dermatitis (HP:0000976)4.28509500
11Abnormality of macrophages (HP:0004311)4.16897769
12Disinhibition (HP:0000734)4.05562847
13Abnormality of glycolipid metabolism (HP:0010969)3.99726065
14Abnormality of liposaccharide metabolism (HP:0010968)3.99726065
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.99726065
16Recurrent gram-negative bacterial infections (HP:0005420)3.62127271
17Soft skin (HP:0000977)3.60332192
18Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.49982240
19Mucopolysacchariduria (HP:0008155)3.48376854
20Urinary glycosaminoglycan excretion (HP:0003541)3.48376854
21Ankle contracture (HP:0006466)3.38416033
22Abnormality of mucopolysaccharide metabolism (HP:0011020)3.33874358
23Abnormality of polysaccharide metabolism (HP:0011012)3.33874358
24Abnormality of glycosaminoglycan metabolism (HP:0004371)3.33874358
25Osteolytic defects of the hand bones (HP:0009699)3.11567178
26Osteolytic defects of the phalanges of the hand (HP:0009771)3.11567178
27Myocardial infarction (HP:0001658)3.10885772
28Nephritis (HP:0000123)3.09229980
29Complement deficiency (HP:0004431)3.08985210
30Follicular hyperkeratosis (HP:0007502)3.06191674
31Wormian bones (HP:0002645)3.05154683
32Prostate neoplasm (HP:0100787)3.05052374
33Abnormality of complement system (HP:0005339)3.03335819
34Bladder diverticulum (HP:0000015)3.00860450
35Hematochezia (HP:0002573)2.97721720
36Spinal rigidity (HP:0003306)2.95628200
37Dilatation of the ascending aorta (HP:0005111)2.94827606
38Premature rupture of membranes (HP:0001788)2.93533452
39Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.89652576
40Thick nail (HP:0001805)2.88953192
41Purpura (HP:0000979)2.87834185
42Cerebral aneurysm (HP:0004944)2.80840927
43Blue sclerae (HP:0000592)2.80414456
44Autoimmune thrombocytopenia (HP:0001973)2.77501324
45Type 1 muscle fiber predominance (HP:0003803)2.76681776
46Increased mean platelet volume (HP:0011877)2.76235326
47Gingivitis (HP:0000230)2.75731174
48Pathologic fracture (HP:0002756)2.74088060
49Atrophic scars (HP:0001075)2.69757146
50Genu recurvatum (HP:0002816)2.67212997
51Mitral stenosis (HP:0001718)2.63777459
52Broad metatarsal (HP:0001783)2.63566423
53Petechiae (HP:0000967)2.60051606
54Abnormality of the vasculature of the conjunctiva (HP:0008054)2.59470296
55Spontaneous hematomas (HP:0007420)2.59118977
56Fragile skin (HP:0001030)2.57999924
57Joint stiffness (HP:0001387)2.55853716
58Orchitis (HP:0100796)2.53430852
59Cervical subluxation (HP:0003308)2.52169235
60Hypoplasia of the iris (HP:0007676)2.51000472
61Abnormal platelet volume (HP:0011876)2.50647575
62Menorrhagia (HP:0000132)2.49969255
63Myositis (HP:0100614)2.49076380
64Abnormality of dentin (HP:0010299)2.46725885
65Agnosia (HP:0010524)2.46168363
66Aneurysm (HP:0002617)2.42995950
67Mitral valve prolapse (HP:0001634)2.41152747
68Vertebral compression fractures (HP:0002953)2.39680098
69Progressive visual loss (HP:0000529)2.38918771
70Recurrent skin infections (HP:0001581)2.38337787
71Bone pain (HP:0002653)2.34408270
72Neonatal short-limb short stature (HP:0008921)2.33935226
73Peripheral demyelination (HP:0011096)2.32668937
74Aortic regurgitation (HP:0001659)2.31994245
75Abnormality of the acetabulum (HP:0003170)2.29612678
76Prolonged bleeding time (HP:0003010)2.29156640
77Conjunctival telangiectasia (HP:0000524)2.29005597
78Mediastinal lymphadenopathy (HP:0100721)2.28506600
79Slender build (HP:0001533)2.25311942
80Periodontitis (HP:0000704)2.24355786
81Loss of speech (HP:0002371)2.23163568
82Aortic valve stenosis (HP:0001650)2.22723963
83Overgrowth (HP:0001548)2.21611828
84Pustule (HP:0200039)2.21594356
85Nausea (HP:0002018)2.20750943
86Shallow orbits (HP:0000586)2.20135456
87Increased variability in muscle fiber diameter (HP:0003557)2.19440528
88Basal ganglia calcification (HP:0002135)2.17696846
89Epistaxis (HP:0000421)2.16735058
90Upper motor neuron abnormality (HP:0002127)2.15794535
91Hyperextensible skin (HP:0000974)2.12835628
92Cardiovascular calcification (HP:0011915)2.12224085
93Nuclear cataract (HP:0100018)2.10603126
94Elbow flexion contracture (HP:0002987)2.10520228
95Joint laxity (HP:0001388)2.07770796
96Arterial tortuosity (HP:0005116)2.05909701
97Aortic dissection (HP:0002647)2.05369285
98Gingival bleeding (HP:0000225)2.05276607
99Abnormality of the lumbar spine (HP:0100712)2.04441456
100Interstitial pulmonary disease (HP:0006530)2.04394013
101Esophageal varix (HP:0002040)2.04328568
102Chronic obstructive pulmonary disease (HP:0006510)2.04145718
103Obstructive lung disease (HP:0006536)2.04145718
104Abnormal delivery (HP:0001787)2.03985478
105Apathy (HP:0000741)2.02659846
106Thin bony cortex (HP:0002753)2.02517297
107Spinal muscular atrophy (HP:0007269)2.02407824
108Diminished motivation (HP:0000745)1.99648403
109Flared iliac wings (HP:0002869)1.98667744
110Bilateral sensorineural hearing impairment (HP:0008619)1.98575385
111Protrusio acetabuli (HP:0003179)1.97430308
112Abnormality of proline metabolism (HP:0010907)1.96277262
113Hydroxyprolinuria (HP:0003080)1.96277262
114Aortic aneurysm (HP:0004942)1.95738646
115Wide anterior fontanel (HP:0000260)1.95391975
116Vascular tortuosity (HP:0004948)1.95084545
117Elevated erythrocyte sedimentation rate (HP:0003565)1.93729024
118Abnormality of skeletal muscle fiber size (HP:0012084)1.93362248
119Polycythemia (HP:0001901)1.92663585
120Wrist flexion contracture (HP:0001239)1.92152684
121J-shaped sella turcica (HP:0002680)1.92020858
122Asymmetric septal hypertrophy (HP:0001670)1.91917924
123Hepatosplenomegaly (HP:0001433)1.90842296
124Optic neuritis (HP:0100653)1.89301150
125Retrobulbar optic neuritis (HP:0100654)1.89301150
126Increased connective tissue (HP:0009025)1.89110674
127Personality changes (HP:0000751)1.88729608
128Segmental peripheral demyelination/remyelination (HP:0003481)1.87224696
129Bruising susceptibility (HP:0000978)1.86492094
130Round ear (HP:0100830)1.85203556
131Absent frontal sinuses (HP:0002688)1.84675525
132Nonimmune hydrops fetalis (HP:0001790)1.84610089
133Proximal tubulopathy (HP:0000114)1.83923672
134Spondylolisthesis (HP:0003302)1.83458864
135Mitral regurgitation (HP:0001653)1.83412185
136Protuberant abdomen (HP:0001538)1.81020996
137Tetraparesis (HP:0002273)1.79569110
138Abnormality of skull ossification (HP:0002703)1.78972113
139Premature loss of primary teeth (HP:0006323)1.77970783
140Delayed closure of the anterior fontanelle (HP:0001476)1.77950617
141Bowel diverticulosis (HP:0005222)1.76485079
142Ovoid vertebral bodies (HP:0003300)1.75490640
143Biconcave vertebral bodies (HP:0004586)1.75180997
144Stomatitis (HP:0010280)1.72652769
145White forelock (HP:0002211)1.71529494
146Striae distensae (HP:0001065)1.71455405
147Distal lower limb muscle weakness (HP:0009053)1.70628840
148Peritonitis (HP:0002586)1.70172296
149Femoral bowing (HP:0002980)1.70020248
150Inappropriate behavior (HP:0000719)1.69746543
151Disproportionate tall stature (HP:0001519)1.69320847
152Thoracic kyphosis (HP:0002942)1.68533794
153Joint hemorrhage (HP:0005261)1.67407656
154Osteomyelitis (HP:0002754)1.67298580
155Poor head control (HP:0002421)1.67244970
156Recurrent fungal infections (HP:0002841)1.67102665
157Retinal atrophy (HP:0001105)1.66984813
158Mucosal telangiectasiae (HP:0100579)1.66823917
159Arterial thrombosis (HP:0004420)1.66069005
160Urticaria (HP:0001025)1.65789415
161Metaphyseal cupping (HP:0003021)1.63125612

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK4.85315339
2BLK4.59182059
3TGFBR24.01156659
4ERN13.10842222
5TYK22.82479474
6IRAK32.82046418
7TBK12.60067494
8CAMK1D2.48205737
9MAP3K142.42211231
10KIT2.36939965
11NEK92.36258444
12AKT32.24901108
13PIK3CG2.18458833
14PDK22.07186235
15SCYL22.02095180
16LIMK11.98915921
17TTN1.95565158
18TRIB31.95470454
19STK101.84917693
20IRAK41.80780173
21CAMK1G1.74000415
22EPHB11.72781089
23RIPK41.72018243
24JAK11.58843197
25CSF1R1.58800631
26MAP3K31.51255796
27IKBKB1.51244588
28RIPK11.43830151
29KDR1.43745799
30ZAP701.43707626
31CDC42BPA1.36021382
32MAP2K31.34369927
33PAK41.30147843
34LATS21.29366321
35PTK61.28265352
36MAP4K11.24360689
37PRKD21.21928917
38PIM21.20608401
39STK31.18751217
40HCK1.18707267
41ACVR1B1.17459062
42TAOK31.17238528
43BMX1.15974403
44PKN21.15166329
45IKBKE1.13282367
46CHUK1.09993766
47NME21.09718568
48CSK1.09267660
49ADRBK11.03596085
50STK381.03450492
51LRRK21.02749456
52EPHA31.00043957
53MOS0.99504211
54ABL20.98985283
55CDK60.98254846
56FER0.97923195
57NTRK10.97183438
58PRKG20.95220210
59GRK70.94748728
60ILK0.94007540
61MAPKAPK30.93723109
62DAPK30.92226148
63WNK40.91938869
64JAK30.91677323
65RPS6KA40.91483210
66LYN0.89939377
67FGR0.89064722
68ERBB40.87526129
69JAK20.87416213
70EGFR0.85849573
71GRK50.85593430
72CAMKK20.84893437
73BMPR20.83956874
74MAPK70.83238140
75TIE10.82767584
76PRKD10.81725614
77ROCK10.80758785
78MAP3K60.77636420
79PIM10.75652440
80PBK0.74782230
81MAP3K120.74637550
82DMPK0.73249161
83FGFR40.72113357
84LCK0.70802820
85EIF2AK20.69097994
86FES0.68499699
87TRPM70.68436145
88MAP2K10.68165585
89PTK20.68125397
90PLK20.67577168
91DDR20.67023154
92LATS10.66298886
93TEC0.65637957
94GSK3A0.65628185
95MELK0.65334472
96ABL10.65289548
97TAOK20.65264943
98PDPK10.64479729
99NUAK10.64086555
100FLT30.63598039
101RPS6KA20.61366136
102SIK10.61104289
103PTK2B0.60590257
104PDGFRB0.59700014
105ICK0.57494078
106PAK10.56312059
107BTK0.56130690
108PAK20.56057463
109MARK30.56013201
110ADRBK20.55977372
111CLK10.55743050
112IGF1R0.55376337
113ROCK20.54953210
114EIF2AK10.54014091
115MAPK120.53477322
116TXK0.53190668
117ITK0.52197292
118WNK30.51984004
119PDGFRA0.51740466
120EPHA20.50514195
121CDK120.49592996
122FGFR30.49290908
123MAP3K130.47806259
124SYK0.47753555
125MAP3K80.47032684
126MET0.46000094
127* PRKCD0.45868277
128MATK0.44781606
129SRC0.43913019
130MTOR0.42618527
131MST1R0.41911636
132STK40.40051790
133EPHB20.39135643
134INSR0.39055571
135CAMKK10.37227970
136MAP3K50.36885404
137PRKCH0.36484321
138TESK10.36240497
139SGK30.35584751
140TGFBR10.34174152
141LMTK20.33430891
142MST40.32853608
143MAPKAPK20.32016398
144PRKAA20.29803307
145CAMK2G0.29298975

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.15559687
2Lysosome_Homo sapiens_hsa041423.93270525
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.45135079
4Other glycan degradation_Homo sapiens_hsa005113.20096238
5Leishmaniasis_Homo sapiens_hsa051402.55512133
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.30090188
7Phagosome_Homo sapiens_hsa041452.26737910
8Osteoclast differentiation_Homo sapiens_hsa043802.23465770
9Malaria_Homo sapiens_hsa051442.20898400
10Tuberculosis_Homo sapiens_hsa051522.17194513
11Pertussis_Homo sapiens_hsa051332.13903493
12Rheumatoid arthritis_Homo sapiens_hsa053231.97364718
13Legionellosis_Homo sapiens_hsa051341.88139648
14Caffeine metabolism_Homo sapiens_hsa002321.65890539
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.60063462
16Complement and coagulation cascades_Homo sapiens_hsa046101.58693011
17Salmonella infection_Homo sapiens_hsa051321.50956213
18Toxoplasmosis_Homo sapiens_hsa051451.47576146
19Shigellosis_Homo sapiens_hsa051311.41304235
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.40438047
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36659953
22Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34167728
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.32714361
24Antigen processing and presentation_Homo sapiens_hsa046121.32298973
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32098251
26Amoebiasis_Homo sapiens_hsa051461.29082242
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25978661
28Collecting duct acid secretion_Homo sapiens_hsa049661.25492066
29Measles_Homo sapiens_hsa051621.25329903
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24187116
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21841798
32Mineral absorption_Homo sapiens_hsa049781.20957614
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.20904267
34Bladder cancer_Homo sapiens_hsa052191.20297182
35Renin-angiotensin system_Homo sapiens_hsa046141.19498032
36B cell receptor signaling pathway_Homo sapiens_hsa046621.19173231
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18460787
38Apoptosis_Homo sapiens_hsa042101.17974342
39Influenza A_Homo sapiens_hsa051641.16792660
40Dilated cardiomyopathy_Homo sapiens_hsa054141.15281800
41Sulfur metabolism_Homo sapiens_hsa009201.10852176
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09681575
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09626261
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08756956
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08387059
46Melanoma_Homo sapiens_hsa052181.06610954
47Sphingolipid metabolism_Homo sapiens_hsa006001.04004147
48TNF signaling pathway_Homo sapiens_hsa046681.02527315
49ECM-receptor interaction_Homo sapiens_hsa045121.00845208
50Graft-versus-host disease_Homo sapiens_hsa053320.93747234
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.93554094
52Viral myocarditis_Homo sapiens_hsa054160.92460078
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90289200
54Vitamin digestion and absorption_Homo sapiens_hsa049770.90147083
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89747493
56Proteoglycans in cancer_Homo sapiens_hsa052050.89534932
57Focal adhesion_Homo sapiens_hsa045100.88287615
58Asthma_Homo sapiens_hsa053100.87403302
59* Endocytosis_Homo sapiens_hsa041440.86846676
60Hepatitis C_Homo sapiens_hsa051600.86428795
61Chemokine signaling pathway_Homo sapiens_hsa040620.84429963
62Small cell lung cancer_Homo sapiens_hsa052220.84072993
63Prion diseases_Homo sapiens_hsa050200.83444940
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82945477
65Gap junction_Homo sapiens_hsa045400.82526568
66Pancreatic cancer_Homo sapiens_hsa052120.82454096
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81004903
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80982077
69Adherens junction_Homo sapiens_hsa045200.80940843
70TGF-beta signaling pathway_Homo sapiens_hsa043500.80810149
71Rap1 signaling pathway_Homo sapiens_hsa040150.79583721
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.79405797
73Pathways in cancer_Homo sapiens_hsa052000.79036022
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.79010667
75Hematopoietic cell lineage_Homo sapiens_hsa046400.76855152
76Hepatitis B_Homo sapiens_hsa051610.76615072
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76225994
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75543947
79Chronic myeloid leukemia_Homo sapiens_hsa052200.74426518
80Glutathione metabolism_Homo sapiens_hsa004800.73212635
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70705202
82Herpes simplex infection_Homo sapiens_hsa051680.70454642
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69907333
84Allograft rejection_Homo sapiens_hsa053300.66845754
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65980815
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.65019888
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62978194
88Pentose phosphate pathway_Homo sapiens_hsa000300.59964172
89Platelet activation_Homo sapiens_hsa046110.59878712
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.57559437
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57162701
92PPAR signaling pathway_Homo sapiens_hsa033200.55779808
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55555225
94Ras signaling pathway_Homo sapiens_hsa040140.54939516
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52995675
96HIF-1 signaling pathway_Homo sapiens_hsa040660.52595253
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52367564
98Glioma_Homo sapiens_hsa052140.51284155
99Galactose metabolism_Homo sapiens_hsa000520.49218048
100Protein digestion and absorption_Homo sapiens_hsa049740.48354916
101African trypanosomiasis_Homo sapiens_hsa051430.47055675
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46343214
103MicroRNAs in cancer_Homo sapiens_hsa052060.44496185
104Vibrio cholerae infection_Homo sapiens_hsa051100.43555055
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.42385699
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41458144
107Arachidonic acid metabolism_Homo sapiens_hsa005900.40419249
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.39867884
109Ovarian steroidogenesis_Homo sapiens_hsa049130.39854922
110Melanogenesis_Homo sapiens_hsa049160.38360674
111Insulin resistance_Homo sapiens_hsa049310.37155507
112Steroid biosynthesis_Homo sapiens_hsa001000.36913460
113Prostate cancer_Homo sapiens_hsa052150.33222001
114Lysine degradation_Homo sapiens_hsa003100.31809432
115Tight junction_Homo sapiens_hsa045300.31743495
116Renal cell carcinoma_Homo sapiens_hsa052110.30055653
117N-Glycan biosynthesis_Homo sapiens_hsa005100.29539085
118Acute myeloid leukemia_Homo sapiens_hsa052210.28781774
119GnRH signaling pathway_Homo sapiens_hsa049120.26593540
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25915683
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.25805634
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25179778
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23966535
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23519085
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.22976091
126Starch and sucrose metabolism_Homo sapiens_hsa005000.21559295
127Notch signaling pathway_Homo sapiens_hsa043300.20980934
128FoxO signaling pathway_Homo sapiens_hsa040680.20805846
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.18761271

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