D2HGDH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.45458203
2L-phenylalanine catabolic process (GO:0006559)6.45458203
3L-phenylalanine metabolic process (GO:0006558)6.27595688
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.27595688
5aromatic amino acid family catabolic process (GO:0009074)5.95813079
6indole-containing compound catabolic process (GO:0042436)5.60009674
7indolalkylamine catabolic process (GO:0046218)5.60009674
8tryptophan catabolic process (GO:0006569)5.60009674
9kynurenine metabolic process (GO:0070189)5.54465140
10alpha-linolenic acid metabolic process (GO:0036109)5.50039367
11mannose metabolic process (GO:0006013)5.49204332
12glyoxylate metabolic process (GO:0046487)5.44414023
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.40799202
14lysine catabolic process (GO:0006554)5.31014318
15lysine metabolic process (GO:0006553)5.31014318
16tryptophan metabolic process (GO:0006568)5.27761494
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.26556080
18bile acid biosynthetic process (GO:0006699)5.06988461
19sulfur amino acid catabolic process (GO:0000098)4.79750620
20cysteine metabolic process (GO:0006534)4.69940715
21regulation of triglyceride catabolic process (GO:0010896)4.62582886
22amino-acid betaine metabolic process (GO:0006577)4.61446839
23urea metabolic process (GO:0019627)4.61093506
24urea cycle (GO:0000050)4.61093506
25high-density lipoprotein particle remodeling (GO:0034375)4.59103868
26* 2-oxoglutarate metabolic process (GO:0006103)4.58213097
27ethanol oxidation (GO:0006069)4.57834958
28serine family amino acid catabolic process (GO:0009071)4.49309415
29valine metabolic process (GO:0006573)4.47379402
30homocysteine metabolic process (GO:0050667)4.45745983
31complement activation, alternative pathway (GO:0006957)4.41727164
32protein carboxylation (GO:0018214)4.35287381
33peptidyl-glutamic acid carboxylation (GO:0017187)4.35287381
34fatty acid beta-oxidation (GO:0006635)4.34235206
35bile acid metabolic process (GO:0008206)4.30917614
36negative regulation of fibrinolysis (GO:0051918)4.30077657
37aromatic amino acid family metabolic process (GO:0009072)4.29571644
38regulation of protein activation cascade (GO:2000257)4.29091354
39alpha-amino acid catabolic process (GO:1901606)4.26954321
40cellular ketone body metabolic process (GO:0046950)4.26829572
41nitrogen cycle metabolic process (GO:0071941)4.22823263
42negative regulation of erythrocyte differentiation (GO:0045647)4.19686747
43fatty acid oxidation (GO:0019395)4.11629387
44triglyceride homeostasis (GO:0070328)4.10848247
45acylglycerol homeostasis (GO:0055090)4.10848247
46regulation of cholesterol esterification (GO:0010872)4.08420391
47regulation of fibrinolysis (GO:0051917)4.06483568
48negative regulation of cholesterol transport (GO:0032375)4.05316772
49negative regulation of sterol transport (GO:0032372)4.05316772
50short-chain fatty acid metabolic process (GO:0046459)4.05123749
51regulation of complement activation (GO:0030449)4.03074586
52lipid oxidation (GO:0034440)4.03024419
53reverse cholesterol transport (GO:0043691)4.02999375
54acetyl-CoA metabolic process (GO:0006084)4.01385675
55fatty acid catabolic process (GO:0009062)4.00786218
56plasma lipoprotein particle clearance (GO:0034381)4.00785970
57glycine metabolic process (GO:0006544)3.97727123
58coenzyme catabolic process (GO:0009109)3.96585496
59cellular amino acid catabolic process (GO:0009063)3.96100260
60tyrosine metabolic process (GO:0006570)3.94077368
61protein-lipid complex remodeling (GO:0034368)3.93608748
62macromolecular complex remodeling (GO:0034367)3.93608748
63plasma lipoprotein particle remodeling (GO:0034369)3.93608748
64cellular biogenic amine catabolic process (GO:0042402)3.90855817
65amine catabolic process (GO:0009310)3.90855817
66aspartate family amino acid catabolic process (GO:0009068)3.89650787
67monocarboxylic acid catabolic process (GO:0072329)3.86911334
68phospholipid efflux (GO:0033700)3.85633260
69indolalkylamine metabolic process (GO:0006586)3.84542168
70carnitine metabolic process (GO:0009437)3.79745078
71carboxylic acid catabolic process (GO:0046395)3.74469370
72organic acid catabolic process (GO:0016054)3.74469370
73phospholipid homeostasis (GO:0055091)3.74465978
74benzene-containing compound metabolic process (GO:0042537)3.73902300
75cellular modified amino acid catabolic process (GO:0042219)3.73492135
76serine family amino acid metabolic process (GO:0009069)3.72768798
77branched-chain amino acid catabolic process (GO:0009083)3.70639740
78fatty acid transmembrane transport (GO:1902001)3.67556309
79ketone body metabolic process (GO:1902224)3.67356207
80tricarboxylic acid metabolic process (GO:0072350)3.63977196
81cellular glucuronidation (GO:0052695)3.61132682
82dicarboxylic acid biosynthetic process (GO:0043650)3.60700378
83branched-chain amino acid metabolic process (GO:0009081)3.60588770
84positive regulation of fatty acid beta-oxidation (GO:0032000)3.59534265
85bile acid and bile salt transport (GO:0015721)3.58072591
86positive regulation of histone deacetylation (GO:0031065)3.55978514
87positive regulation of triglyceride lipase activity (GO:0061365)3.54949932
88positive regulation of lipoprotein lipase activity (GO:0051006)3.54949932
89regulation of cholesterol metabolic process (GO:0090181)3.54154589
90serine family amino acid biosynthetic process (GO:0009070)3.53022647
91positive regulation of lipid catabolic process (GO:0050996)3.52258902
92imidazole-containing compound metabolic process (GO:0052803)3.50974401
93glutamate metabolic process (GO:0006536)3.44299736
94biotin metabolic process (GO:0006768)3.43061385
95carnitine shuttle (GO:0006853)3.41131895
96plasma lipoprotein particle assembly (GO:0034377)3.39886476
97negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.39858131
98regulation of ARF GTPase activity (GO:0032312)3.36092859
99cholesterol homeostasis (GO:0042632)3.35743313
100cholesterol efflux (GO:0033344)3.34104240
101thymic T cell selection (GO:0045061)3.33883110
102low-density lipoprotein particle remodeling (GO:0034374)3.32665821
103drug transmembrane transport (GO:0006855)3.31788862
104regulation of cholesterol homeostasis (GO:2000188)3.30971135
105negative regulation of lipase activity (GO:0060192)3.29752509
106nicotinamide nucleotide biosynthetic process (GO:0019359)3.28717514
107negative regulation of cell size (GO:0045792)3.25933118
108positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.11617448
109regulation of gamma-delta T cell differentiation (GO:0045586)3.11427805
110positive regulation of protein kinase C signaling (GO:0090037)3.06707150
111semaphorin-plexin signaling pathway (GO:0071526)3.05788090
112positive thymic T cell selection (GO:0045059)3.04200840
113regulation of gamma-delta T cell activation (GO:0046643)3.01812509
114regulation of fatty acid beta-oxidation (GO:0031998)2.92941910
115negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.92096790
116regulation of extracellular matrix disassembly (GO:0010715)2.91569879
117antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.90386393
118negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.81098823
119negative regulation of cell killing (GO:0031342)2.81098823
120diacylglycerol metabolic process (GO:0046339)2.80547057
121positive regulation of gamma-delta T cell activation (GO:0046645)2.78617110
122antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.77808838
123positive regulation of protein deacetylation (GO:0090312)2.76724698
124regulation of hydrogen peroxide metabolic process (GO:0010310)2.76701176
125germinal center formation (GO:0002467)2.75317002
126antigen processing and presentation of endogenous antigen (GO:0019883)2.72296348
127negative regulation of fatty acid transport (GO:2000192)2.71087713
128endothelial cell chemotaxis (GO:0035767)2.69318714
129T cell selection (GO:0045058)2.64912717
130positive regulation of triglyceride metabolic process (GO:0090208)2.60833203
131negative regulation of granulocyte differentiation (GO:0030853)2.60494871
132response to muramyl dipeptide (GO:0032495)2.59980161
133histone H3 deacetylation (GO:0070932)2.56846542
134histone H4 deacetylation (GO:0070933)2.54870351
135positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.53937189
136apoptotic process involved in morphogenesis (GO:0060561)2.51787692
137regulation of apoptotic cell clearance (GO:2000425)2.51543260
138CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.50946055
139insulin-like growth factor receptor signaling pathway (GO:0048009)2.48268708
140regulation of monocyte differentiation (GO:0045655)2.47617593
141detection of bacterium (GO:0016045)2.47335515
142ethanol metabolic process (GO:0006067)2.46669901
143positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.45053778
144activation of JUN kinase activity (GO:0007257)2.42469154
145positive regulation of fatty acid oxidation (GO:0046321)2.41902572
146NIK/NF-kappaB signaling (GO:0038061)2.38803225
147negative thymic T cell selection (GO:0045060)2.36657367
148positive regulation of CREB transcription factor activity (GO:0032793)2.35498534
149positive regulation of cholesterol efflux (GO:0010875)2.34967745
150positive regulation of fatty acid biosynthetic process (GO:0045723)2.32974440
151regulation of fatty acid oxidation (GO:0046320)2.32051193
152regulation of extracellular matrix organization (GO:1903053)2.29558889
153skeletal muscle adaptation (GO:0043501)2.28474341
154phosphatidylglycerol biosynthetic process (GO:0006655)2.28014341
155regulation of triglyceride metabolic process (GO:0090207)2.27940635
156lytic vacuole organization (GO:0080171)2.25843271
157lysosome organization (GO:0007040)2.25843271
158tolerance induction (GO:0002507)2.25046106
159regulation of glucose import in response to insulin stimulus (GO:2001273)2.24685670
160cell volume homeostasis (GO:0006884)2.24407277
161regulation of fatty acid biosynthetic process (GO:0042304)2.23821683
162positive regulation of fatty acid metabolic process (GO:0045923)2.22262263
163detection of other organism (GO:0098543)2.22185006
164positive regulation of Cdc42 GTPase activity (GO:0043089)2.21531745
165acute-phase response (GO:0006953)2.20312572
166epoxygenase P450 pathway (GO:0019373)2.19144482
167retrograde transport, endosome to Golgi (GO:0042147)2.19079112
168histone H3-K4 trimethylation (GO:0080182)2.18672976
169quaternary ammonium group transport (GO:0015697)2.16590186
170negative regulation of innate immune response (GO:0045824)2.16258051
171cell-cell junction maintenance (GO:0045217)2.15733557
172negative regulation of interleukin-8 production (GO:0032717)2.14533913
173positive regulation of extracellular matrix organization (GO:1903055)2.13292636
174regulation of histone H3-K27 methylation (GO:0061085)2.13235409
175striated muscle atrophy (GO:0014891)2.13215689
176regulation of type I interferon-mediated signaling pathway (GO:0060338)2.13200800
177regulation of ruffle assembly (GO:1900027)2.13113802
178regulation of histone deacetylation (GO:0031063)2.12726514
179negative regulation of viral release from host cell (GO:1902187)2.11211328
180activation of MAPKKK activity (GO:0000185)2.09151349

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.77834858
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.91766398
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.26887303
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.18544149
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.50788442
6LXR_22158963_ChIP-Seq_LIVER_Mouse5.34783755
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.28282096
8* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.15037755
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.44463772
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.21388535
11* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.05821085
12GATA1_22025678_ChIP-Seq_K562_Human2.99587890
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.79294607
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.66689973
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.35008317
16* ELK3_25401928_ChIP-Seq_HUVEC_Human2.30659224
17KDM2B_26808549_Chip-Seq_DND41_Human2.28613592
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.21254134
19RACK7_27058665_Chip-Seq_MCF-7_Human2.20256506
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.18998013
21P68_20966046_ChIP-Seq_HELA_Human2.03032565
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.00699573
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.91416010
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88421138
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.86011557
26CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.83590463
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74740697
28CLOCK_20551151_ChIP-Seq_293T_Human1.74293634
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70801447
30SA1_27219007_Chip-Seq_ERYTHROID_Human1.70008111
31KDM2B_26808549_Chip-Seq_K562_Human1.69324309
32SCL_19346495_ChIP-Seq_HPC-7_Human1.68289028
33CTCF_27219007_Chip-Seq_ERYTHROID_Human1.67660481
34SMC4_20622854_ChIP-Seq_HELA_Human1.66437757
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62795287
36* ELF1_20517297_ChIP-Seq_JURKAT_Human1.62468702
37EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.62070926
38DROSHA_22980978_ChIP-Seq_HELA_Human1.61590388
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60491915
40MAF_26560356_Chip-Seq_TH2_Human1.58558590
41TET1_21451524_ChIP-Seq_MESCs_Mouse1.58534080
42RUNX1_27514584_Chip-Seq_MCF-7_Human1.54725238
43* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.54300493
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53850197
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.52597930
46* CREB1_26743006_Chip-Seq_LNCaP_Human1.52141648
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51927394
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51905199
49CTCF_27219007_Chip-Seq_Bcells_Human1.50968712
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45658223
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.45384851
52KDM2B_26808549_Chip-Seq_JURKAT_Human1.45379270
53SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45310611
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40884880
55* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.37843464
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33177560
57FOXA2_19822575_ChIP-Seq_HepG2_Human1.32481673
58UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31272223
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30955149
60E2F1_20622854_ChIP-Seq_HELA_Human1.30096698
61* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29644862
62CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28503251
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25896947
64* TP63_22573176_ChIP-Seq_HFKS_Human1.23681554
65PHF8_20622854_ChIP-Seq_HELA_Human1.22322175
66SA1_27219007_Chip-Seq_Bcells_Human1.20802579
67* HNF4A_19822575_ChIP-Seq_HepG2_Human1.17007094
68* CTCF_26484167_Chip-Seq_Bcells_Mouse1.16155913
69TP53_22127205_ChIP-Seq_IMR90_Human1.15736583
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15523843
71RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14532281
72CTCF_21964334_ChIP-Seq_BJAB-B_Human1.14104190
73MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.13305167
74* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12905243
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.11835868
76* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10972972
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10830069
78MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10551863
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10017183
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09182254
81ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08391957
82NCOR1_26117541_ChIP-Seq_K562_Human1.08141031
83SPI1_23127762_ChIP-Seq_K562_Human1.07118740
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.07039620
85* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06180828
86GATA1_19941827_ChIP-Seq_MEL_Mouse1.03983521
87SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03283415
88PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02643590
89* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02463668
90RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02313503
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00615678
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00491141
93* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99941273
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99926890
95NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98454984
96STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98267476
97ZNF263_19887448_ChIP-Seq_K562_Human0.96825596
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96321905
99STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95769428
100SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95747636
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95057554
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92155222
103E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91192964
104VDR_21846776_ChIP-Seq_THP-1_Human0.91085079
105GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90095759
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89724211
107LXR_22292898_ChIP-Seq_THP-1_Human0.88965491
108GATA1_19941826_ChIP-Seq_K562_Human0.88234256
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87543499
110ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87223817
111GATA2_19941826_ChIP-Seq_K562_Human0.86992212
112GATA4_25053715_ChIP-Seq_YYC3_Human0.86814511
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86600561
114MAF_26560356_Chip-Seq_TH1_Human0.84525188
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84261253
116MYC_22102868_ChIP-Seq_BL_Human0.83299335
117EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.82349948
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80549774
119TBX20_22080862_ChIP-Seq_HEART_Mouse0.79945350
120TBX20_22328084_ChIP-Seq_HEART_Mouse0.79945350
121ESR1_21235772_ChIP-Seq_MCF-7_Human0.79625732
122LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78945801
123IRF8_27001747_Chip-Seq_BMDM_Mouse0.78283351
124NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.78054657
125* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.77919936
126TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.76535020
127NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.73881256
128ELF1_17652178_ChIP-ChIP_JURKAT_Human0.73685357
129HTT_18923047_ChIP-ChIP_STHdh_Human0.73414565
130GATA2_22383799_ChIP-Seq_G1ME_Mouse0.72668750
131SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72341699
132PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.72246643
133TCF7_22412390_ChIP-Seq_EML_Mouse0.72239505
134NOTCH1_21737748_ChIP-Seq_TLL_Human0.72158523
135* MYB_26560356_Chip-Seq_TH1_Human0.71087447
136ESR2_21235772_ChIP-Seq_MCF-7_Human0.70052285
137* CEBPB_22108803_ChIP-Seq_LS180_Human0.68528937
138SRF_21415370_ChIP-Seq_HL-1_Mouse0.68378101
139ESR1_15608294_ChIP-ChIP_MCF-7_Human0.68243552
140PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.67893011
141Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.65622132
142RUNX_20019798_ChIP-Seq_JUKART_Human0.65425254
143FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.64695853
144SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.64657430
145UTX_26944678_Chip-Seq_JUKART_Human0.64266762
146BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63940599
147SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.63083837
148RARA_24833708_ChIP-Seq_LIVER_Mouse0.62850261
149VDR_24763502_ChIP-Seq_THP-1_Human0.62654817
150TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.60366398
151RARB_24833708_ChIP-Seq_LIVER_Mouse0.60357817
152BCL6_27268052_Chip-Seq_Bcells_Human0.59538724
153CDX2_20551321_ChIP-Seq_CACO-2_Human0.59075068
154* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.58528031
155CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.58275152
156* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.58249462
157AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.57821780
158BCOR_27268052_Chip-Seq_Bcells_Human0.57234618
159IRF8_21731497_ChIP-ChIP_J774_Mouse0.56625418

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.76310099
2MP0005360_urolithiasis6.54347963
3MP0005085_abnormal_gallbladder_physiolo5.39157841
4MP0005365_abnormal_bile_salt5.36114660
5MP0008875_abnormal_xenobiotic_pharmacok4.10942455
6MP0003806_abnormal_nucleotide_metabolis3.82958610
7MP0003172_abnormal_lysosome_physiology3.64623879
8MP0003252_abnormal_bile_duct3.28008117
9MP0010329_abnormal_lipoprotein_level3.23593376
10MP0009840_abnormal_foam_cell3.07829057
11MP0005332_abnormal_amino_acid2.55363947
12MP0005083_abnormal_biliary_tract2.39290195
13MP0001666_abnormal_nutrient_absorption2.34207978
14MP0003191_abnormal_cellular_cholesterol2.31201417
15MP0000609_abnormal_liver_physiology2.13954468
16MP0002837_dystrophic_cardiac_calcinosis2.11340115
17MP0003195_calcinosis2.10836545
18MP0002118_abnormal_lipid_homeostasis2.04274262
19MP0005319_abnormal_enzyme/_coenzyme1.92108646
20MP0001849_ear_inflammation1.90973733
21MP0001873_stomach_inflammation1.84850589
22MP0004019_abnormal_vitamin_homeostasis1.82037610
23MP0005670_abnormal_white_adipose1.80905615
24MP0008260_abnormal_autophagy1.78821929
25MP0004130_abnormal_muscle_cell1.75504608
26MP0009278_abnormal_bone_marrow1.72392470
27MP0002933_joint_inflammation1.68948259
28MP0005076_abnormal_cell_differentiation1.68933333
29MP0005584_abnormal_enzyme/coenzyme_acti1.68262222
30MP0002249_abnormal_larynx_morphology1.68049759
31MP0003303_peritoneal_inflammation1.66575686
32MP0004947_skin_inflammation1.65491147
33MP0004381_abnormal_hair_follicle1.64622690
34MP0003763_abnormal_thymus_physiology1.64098533
35MP0002138_abnormal_hepatobiliary_system1.60490497
36MP0001764_abnormal_homeostasis1.60239258
37MP0003868_abnormal_feces_composition1.56820259
38MP0010155_abnormal_intestine_physiology1.52191620
39MP0003186_abnormal_redox_activity1.51253496
40MP0009643_abnormal_urine_homeostasis1.48697973
41MP0005409_darkened_coat_color1.47217365
42MP0006036_abnormal_mitochondrial_physio1.44702219
43MP0000751_myopathy1.44363048
44MP0003879_abnormal_hair_cell1.43622082
45MP0009384_cardiac_valve_regurgitation1.42060842
46MP0000678_abnormal_parathyroid_gland1.41378681
47MP0003656_abnormal_erythrocyte_physiolo1.40863291
48MP0003646_muscle_fatigue1.38610717
49MP0005666_abnormal_adipose_tissue1.34644605
50MP0002822_catalepsy1.33960579
51MP0005000_abnormal_immune_tolerance1.32797254
52MP0003279_aneurysm1.32576021
53MP0005671_abnormal_response_to1.31725979
54MP0009333_abnormal_splenocyte_physiolog1.31449655
55MP0002723_abnormal_immune_serum1.24232718
56MP0004858_abnormal_nervous_system1.23093106
57MP0000598_abnormal_liver_morphology1.22196224
58MP0009764_decreased_sensitivity_to1.20493117
59MP0003866_abnormal_defecation1.19909214
60MP0002452_abnormal_antigen_presenting1.19320496
61MP0001533_abnormal_skeleton_physiology1.18857198
62MP0003453_abnormal_keratinocyte_physiol1.17781845
63MP0003705_abnormal_hypodermis_morpholog1.15828207
64MP0003183_abnormal_peptide_metabolism1.15224072
65MP0001819_abnormal_immune_cell1.14977827
66MP0002998_abnormal_bone_remodeling1.14386559
67MP0002420_abnormal_adaptive_immunity1.13873187
68MP0001958_emphysema1.13424008
69MP0008469_abnormal_protein_level1.13036695
70MP0009763_increased_sensitivity_to1.12036677
71MP0000003_abnormal_adipose_tissue1.11918241
72MP0005377_hearing/vestibular/ear_phenot1.03976274
73MP0003878_abnormal_ear_physiology1.03976274
74MP0001348_abnormal_lacrimal_gland1.02597833
75MP0005451_abnormal_body_composition1.01120730
76MP0002254_reproductive_system_inflammat1.01049783
77MP0005636_abnormal_mineral_homeostasis0.99441203
78MP0000013_abnormal_adipose_tissue0.99389723
79MP0001853_heart_inflammation0.99331084
80MP0002971_abnormal_brown_adipose0.97502562
81MP0004510_myositis0.97054907
82MP0009697_abnormal_copulation0.96506014
83MP0002405_respiratory_system_inflammati0.95874937
84MP0003724_increased_susceptibility_to0.94746369
85MP0005084_abnormal_gallbladder_morpholo0.94068220
86MP0000685_abnormal_immune_system0.93831461
87MP0004043_abnormal_pH_regulation0.92228404
88MP0002876_abnormal_thyroid_physiology0.92144929
89MP0005330_cardiomyopathy0.91606656
90MP0000716_abnormal_immune_system0.91255956
91MP0002078_abnormal_glucose_homeostasis0.90742442
92MP0006035_abnormal_mitochondrial_morpho0.89846583
93MP0010234_abnormal_vibrissa_follicle0.89658163
94MP0009642_abnormal_blood_homeostasis0.89620033
95MP0003045_fibrosis0.88913817
96MP0005334_abnormal_fat_pad0.88238304
97MP0001663_abnormal_digestive_system0.86907066
98MP0010368_abnormal_lymphatic_system0.85299748
99MP0005464_abnormal_platelet_physiology0.84940222
100MP0001765_abnormal_ion_homeostasis0.83873740
101MP0002398_abnormal_bone_marrow0.83536708
102MP0005266_abnormal_metabolism0.83518614
103MP0000858_altered_metastatic_potential0.81838158
104MP0000681_abnormal_thyroid_gland0.81596914
105MP0005503_abnormal_tendon_morphology0.81402846
106MP0004185_abnormal_adipocyte_glucose0.80308413
107MP0003436_decreased_susceptibility_to0.80111353
108MP0005647_abnormal_sex_gland0.79796719
109MP0003300_gastrointestinal_ulcer0.78735730
110MP0005376_homeostasis/metabolism_phenot0.77679560
111MP0004036_abnormal_muscle_relaxation0.76774237
112MP0001835_abnormal_antigen_presentation0.76742274
113MP0009115_abnormal_fat_cell0.72888192
114MP0009765_abnormal_xenobiotic_induced0.72446999
115MP0004084_abnormal_cardiac_muscle0.70538277
116MP0002396_abnormal_hematopoietic_system0.69976734
117MP0002136_abnormal_kidney_physiology0.68427804
118MP0009785_altered_susceptibility_to0.68016104
119MP0005535_abnormal_body_temperature0.66014619
120MP0000604_amyloidosis0.65518015
121MP0001756_abnormal_urination0.65216174
122MP0003011_delayed_dark_adaptation0.65085587
123MP0005375_adipose_tissue_phenotype0.64305649
124MP0002166_altered_tumor_susceptibility0.64095222
125MP0010630_abnormal_cardiac_muscle0.63843981
126MP0005058_abnormal_lysosome_morphology0.63258993
127MP0005385_cardiovascular_system_phenoty0.62815804
128MP0001544_abnormal_cardiovascular_syste0.62815804
129MP0005025_abnormal_response_to0.62752200
130MP0001845_abnormal_inflammatory_respons0.61102422
131MP0001800_abnormal_humoral_immune0.60868377
132MP0004215_abnormal_myocardial_fiber0.59945782
133MP0002132_abnormal_respiratory_system0.59829796
134MP0002928_abnormal_bile_duct0.59616304
135MP0001790_abnormal_immune_system0.57446150
136MP0005387_immune_system_phenotype0.57446150
137MP0008961_abnormal_basal_metabolism0.56933777
138MP0005448_abnormal_energy_balance0.55988869
139MP0003221_abnormal_cardiomyocyte_apopto0.55074251
140MP0002970_abnormal_white_adipose0.54951600
141MP0001661_extended_life_span0.52975590
142MP0004087_abnormal_muscle_fiber0.51813026
143MP0000249_abnormal_blood_vessel0.51573083
144MP0002419_abnormal_innate_immunity0.51362136
145MP0002269_muscular_atrophy0.50654280
146MP0001545_abnormal_hematopoietic_system0.50636055
147MP0005397_hematopoietic_system_phenotyp0.50636055
148MP0000343_altered_response_to0.49710463
149MP0006138_congestive_heart_failure0.47864858
150MP0004147_increased_porphyrin_level0.47716351
151MP0000230_abnormal_systemic_arterial0.47367611
152MP0000689_abnormal_spleen_morphology0.47045844

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.09694922
2Intrahepatic cholestasis (HP:0001406)5.78658945
3Deep venous thrombosis (HP:0002625)5.54466564
4Xanthomatosis (HP:0000991)5.29794180
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.01372997
6Hypobetalipoproteinemia (HP:0003563)4.95507862
7Prolonged partial thromboplastin time (HP:0003645)4.84192714
8Hyperammonemia (HP:0001987)4.79404978
9Hyperlipoproteinemia (HP:0010980)4.77733418
10Obstructive sleep apnea (HP:0002870)4.67349879
11Ketosis (HP:0001946)4.56555782
12Hypoglycemic coma (HP:0001325)4.34439593
13Hyperglycinuria (HP:0003108)4.31137454
14Abnormality of fatty-acid metabolism (HP:0004359)4.28295524
15Complement deficiency (HP:0004431)4.11451421
16J-shaped sella turcica (HP:0002680)4.10967607
17Abnormality of serine family amino acid metabolism (HP:0010894)4.08388222
18Abnormality of glycine metabolism (HP:0010895)4.08388222
19Hyperglycinemia (HP:0002154)4.07604451
20Broad face (HP:0000283)4.07083861
21Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.96463865
22Hypolipoproteinemia (HP:0010981)3.90921522
23Joint hemorrhage (HP:0005261)3.87607352
24Epidermoid cyst (HP:0200040)3.78185691
25Dysostosis multiplex (HP:0000943)3.76504828
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.75379052
27Ketoacidosis (HP:0001993)3.74857077
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.71744333
29Urinary glycosaminoglycan excretion (HP:0003541)3.68266455
30Mucopolysacchariduria (HP:0008155)3.68266455
31Abnormality of mucopolysaccharide metabolism (HP:0011020)3.67014221
32Abnormality of polysaccharide metabolism (HP:0011012)3.67014221
33Abnormality of glycosaminoglycan metabolism (HP:0004371)3.67014221
34Cervical subluxation (HP:0003308)3.60175715
35Hypoalphalipoproteinemia (HP:0003233)3.56871100
36Abnormality of sulfur amino acid metabolism (HP:0004339)3.53818468
37Abnormality of aspartate family amino acid metabolism (HP:0010899)3.48963755
38* Abnormality of dicarboxylic acid metabolism (HP:0010995)3.48594908
39* Dicarboxylic aciduria (HP:0003215)3.48594908
40Abnormality of the common coagulation pathway (HP:0010990)3.40514453
41Thin bony cortex (HP:0002753)3.37278834
42Abnormality of methionine metabolism (HP:0010901)3.33689295
43Conjugated hyperbilirubinemia (HP:0002908)3.24342050
44Colitis (HP:0002583)3.21836320
45Hyperbilirubinemia (HP:0002904)3.20855997
46Generalized aminoaciduria (HP:0002909)3.14693811
47Fat malabsorption (HP:0002630)3.14170223
48Exercise-induced myalgia (HP:0003738)3.13966479
49Abnormality of the intrinsic pathway (HP:0010989)3.12792206
50Abnormality of serum amino acid levels (HP:0003112)3.03090887
51Joint stiffness (HP:0001387)2.99505295
52Cerebral aneurysm (HP:0004944)2.99213101
53Hypercholesterolemia (HP:0003124)2.97387117
54Metabolic acidosis (HP:0001942)2.96595672
55Abnormality of complement system (HP:0005339)2.95669991
56Abnormality of pyrimidine metabolism (HP:0004353)2.85670365
57Asymmetric septal hypertrophy (HP:0001670)2.82621963
58Abnormality of nucleobase metabolism (HP:0010932)2.81364655
59Myocardial infarction (HP:0001658)2.80038357
60Abnormality of purine metabolism (HP:0004352)2.79211800
61Lethargy (HP:0001254)2.77533670
62Myopathic facies (HP:0002058)2.76212518
63Lymphangioma (HP:0100764)2.72830922
64Cerebral edema (HP:0002181)2.68787214
65Increased connective tissue (HP:0009025)2.67402411
66Deformed sella turcica (HP:0002681)2.61685688
67Myoglobinuria (HP:0002913)2.58206201
68Eczematoid dermatitis (HP:0000976)2.57404068
69Biconcave vertebral bodies (HP:0004586)2.57022409
70Glomerulonephritis (HP:0000099)2.55151634
71Hepatocellular carcinoma (HP:0001402)2.54629135
72Increased IgE level (HP:0003212)2.53571560
73Emphysema (HP:0002097)2.52864628
74Gout (HP:0001997)2.50313437
75* Stridor (HP:0010307)2.47356053
76* Delayed CNS myelination (HP:0002188)2.43546949
77Gastrointestinal inflammation (HP:0004386)2.43240678
78Easy fatigability (HP:0003388)2.41042265
79Cerebral palsy (HP:0100021)2.40047619
80* Vomiting (HP:0002013)2.38921193
81Distal lower limb amyotrophy (HP:0008944)2.38452016
82Flat acetabular roof (HP:0003180)2.37250199
83Skin nodule (HP:0200036)2.37100656
84Distal lower limb muscle weakness (HP:0009053)2.36635449
85Hepatic necrosis (HP:0002605)2.33605685
86Hypochromic microcytic anemia (HP:0004840)2.32923519
87Acanthocytosis (HP:0001927)2.30554067
88Steatorrhea (HP:0002570)2.29317273
89Late onset (HP:0003584)2.29182810
90Nausea (HP:0002018)2.29051300
91Increased neuronal autofluorescent lipopigment (HP:0002074)2.28030193
92Increased cerebral lipofuscin (HP:0011813)2.27089897
93Thoracic kyphosis (HP:0002942)2.26430590
94Inflammation of the large intestine (HP:0002037)2.26159323
95Pancreatitis (HP:0001733)2.26032302
96Vascular calcification (HP:0004934)2.25595808
97Hypoglycemic seizures (HP:0002173)2.25168524
98Renal cortical cysts (HP:0000803)2.23998980
99Abnormality of the fingertips (HP:0001211)2.22365584
100Neonatal onset (HP:0003623)2.20090852
101Abnormality of the thoracic spine (HP:0100711)2.19898913
102Abnormality of proline metabolism (HP:0010907)2.19319892
103Hydroxyprolinuria (HP:0003080)2.19319892
104Rhabdomyolysis (HP:0003201)2.18986471
105Nuclear cataract (HP:0100018)2.18359216
106Systemic lupus erythematosus (HP:0002725)2.17659119
107Ulnar deviation of the wrist (HP:0003049)2.16506759
108Gingival bleeding (HP:0000225)2.15372172
109Recurrent gram-negative bacterial infections (HP:0005420)2.15244240
110Proximal tubulopathy (HP:0000114)2.14158357
111Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.12655770
112Hyperinsulinemic hypoglycemia (HP:0000825)2.12176714
113Spontaneous abortion (HP:0005268)2.11859841
114Myositis (HP:0100614)2.10679752
115Flared iliac wings (HP:0002869)2.10278860
116Cholelithiasis (HP:0001081)2.08493059
117Round ear (HP:0100830)2.08078719
118Purpura (HP:0000979)2.06592870
119Esophageal varix (HP:0002040)2.05726039
120Abnormal gallbladder morphology (HP:0012437)2.05126439
121Polygenic inheritance (HP:0010982)2.04077024
122Brushfield spots (HP:0001088)2.03570367
123Thrombophlebitis (HP:0004418)2.02907261
124Increased muscle lipid content (HP:0009058)2.02768406
125Mitral stenosis (HP:0001718)2.02559582
126Gastrointestinal stroma tumor (HP:0100723)2.02513173
127Nephritis (HP:0000123)2.02277356
128Mildly elevated creatine phosphokinase (HP:0008180)2.00643624
129Increased purine levels (HP:0004368)1.99289944
130Hyperuricemia (HP:0002149)1.99289944
131Seborrheic dermatitis (HP:0001051)1.99226890
132Elevated hepatic transaminases (HP:0002910)1.99088961
133Bulbar palsy (HP:0001283)1.98693993
134Prolonged bleeding time (HP:0003010)1.98559078
135Spastic diplegia (HP:0001264)1.97696997
136Cardiovascular calcification (HP:0011915)1.97451691
137Atelectasis (HP:0100750)1.95954974
138Increased serum ferritin (HP:0003281)1.95744853
139Pustule (HP:0200039)1.94762619
140Hypertriglyceridemia (HP:0002155)1.94001490
141Increased variability in muscle fiber diameter (HP:0003557)1.93827160
142Irritability (HP:0000737)1.93738716
143Hyperacusis (HP:0010780)1.93361594
144Polycythemia (HP:0001901)1.93078957
145Elevated erythrocyte sedimentation rate (HP:0003565)1.92321635
146Spinal canal stenosis (HP:0003416)1.90723250
147Aneurysm (HP:0002617)1.89902893
148Poikilocytosis (HP:0004447)1.89733157
149Glycosuria (HP:0003076)1.89105270
150Abnormality of urine glucose concentration (HP:0011016)1.89105270
151Palpitations (HP:0001962)1.88008644
152Gingivitis (HP:0000230)1.87994031
153Abnormality of iron homeostasis (HP:0011031)1.87725581
154Restrictive lung disease (HP:0002091)1.87584660
155Opisthotonus (HP:0002179)1.86766696
156Centrally nucleated skeletal muscle fibers (HP:0003687)1.86305169
157Diaphragmatic weakness (HP:0009113)1.85721576
158Right ventricular cardiomyopathy (HP:0011663)1.84158917
159Ragged-red muscle fibers (HP:0003200)1.84136131
160Mitral regurgitation (HP:0001653)1.84098154
161Hemorrhage of the eye (HP:0011885)1.83989324
162Abnormality of transition element cation homeostasis (HP:0011030)1.82064144
163Type 1 muscle fiber predominance (HP:0003803)1.81301853
164Gastrointestinal infarctions (HP:0005244)1.81016953
165Hyperglycemia (HP:0003074)1.80536346
166Malnutrition (HP:0004395)1.80517820
167Amyloidosis (HP:0011034)1.80200442
168Hypophosphatemia (HP:0002148)1.79719654
169Recurrent fungal infections (HP:0002841)1.79467081
170Hypoplasia of the odontoid process (HP:0003311)1.73934473
171Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.73364948
172Abnormality of liposaccharide metabolism (HP:0010968)1.73282438
173Abnormality of glycosphingolipid metabolism (HP:0004343)1.73282438
174Abnormality of glycolipid metabolism (HP:0010969)1.73282438
175Upper limb amyotrophy (HP:0009129)1.71213932
176Distal upper limb amyotrophy (HP:0007149)1.71213932
177Bronchomalacia (HP:0002780)1.70410258
178Abnormality of skeletal muscle fiber size (HP:0012084)1.70397760
179Loss of speech (HP:0002371)1.69967122
180Abnormality of the sella turcica (HP:0002679)1.69910529
181Visceral angiomatosis (HP:0100761)1.65932790
182Abnormality of the Achilles tendon (HP:0005109)1.65145068
183Protrusio acetabuli (HP:0003179)1.64813692
184Chronic obstructive pulmonary disease (HP:0006510)1.64112322
185Obstructive lung disease (HP:0006536)1.64112322
186Menorrhagia (HP:0000132)1.63558719
187Rectal prolapse (HP:0002035)1.63081629
188Cellulitis (HP:0100658)1.63054924

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.67102268
2FLT33.49450562
3ERN13.31342284
4PKN22.94550161
5FGFR42.73805748
6SIK12.66821870
7TNK22.45826776
8TAOK32.34310869
9TRIB32.32864143
10EEF2K2.21578158
11MAP4K12.17006747
12TYK22.06262351
13ICK1.89387794
14SMG11.88993395
15KIT1.76010516
16RIPK41.73896995
17TTN1.73753357
18PRPF4B1.71325725
19MAPK111.70108645
20INSRR1.64897903
21MAPKAPK31.61922579
22MARK21.61563247
23TBK11.59686141
24SIK21.59170054
25MAP3K141.57111191
26CDC42BPA1.55741131
27MAP2K61.53922958
28RIPK11.49028729
29MAP2K31.47588203
30PRKD21.47403371
31CSF1R1.47257526
32TIE11.45745453
33STK161.44373243
34PRKAA21.43585303
35BTK1.41405427
36GRK61.40444287
37PDK31.39928945
38PDK41.39928945
39EPHA21.36879740
40TRPM71.32110861
41TGFBR21.31519253
42MYLK1.26588009
43MAP3K101.25723815
44BLK1.24194559
45TEC1.22730491
46NEK91.17425160
47RPS6KA21.15210146
48IRAK31.12642065
49PTK61.12542622
50KDR1.11289561
51JAK11.10310300
52PIK3CG1.09987281
53MST1R1.08332769
54JAK31.07729835
55MAP3K71.05579521
56JAK21.04194249
57IKBKE1.02053322
58LMTK21.02023344
59ITK1.01177623
60CAMKK11.00965038
61NME21.00024020
62HIPK20.98025853
63NME10.97852103
64MAPK120.94360949
65ZAP700.92410426
66PDK20.88206062
67MTOR0.85536282
68PDPK10.84837796
69MAPK40.84181381
70NLK0.82159152
71CDK120.81446677
72CHUK0.80395211
73PHKG10.78571487
74PHKG20.78571487
75OBSCN0.78570694
76MAP3K30.78235664
77CAMK1D0.78101443
78TGFBR10.76858777
79PRKAA10.75026688
80TAOK10.74383060
81MAP3K10.74308775
82BMX0.73280071
83FRK0.72652854
84DDR20.72057154
85PIK3CA0.71323664
86FES0.69382742
87PINK10.68742801
88SYK0.68216272
89TYRO30.67493139
90MAP2K20.66867787
91MAPK70.65554063
92EPHB10.65075086
93PDK10.64992076
94SIK30.64567935
95PRKD30.62032393
96FGFR20.59664269
97FGFR30.58980487
98ACVR1B0.58692341
99CSK0.58417403
100PDGFRA0.57817904
101MAPK150.57632209
102CDK40.55625421
103ABL20.54161429
104LRRK20.53329499
105DYRK1B0.53103631
106ERBB20.52457797
107RET0.52171931
108TXK0.51788945
109RPS6KA60.51123660
110CDK60.50081513
111PRKCH0.49100068
112PRKACG0.48643571
113DAPK20.48382979
114STK100.47807784
115MAP3K110.47488402
116EPHA30.47464927
117MAP3K130.46768987
118SGK30.46577518
119IKBKB0.46224052
120PRKG20.44985011
121HCK0.44343402
122SGK20.44212278
123MAPK30.43885766
124RPS6KB20.43602076
125PIM10.43115870
126RPS6KC10.43030309
127RPS6KL10.43030309
128RPS6KA40.42963535
129STK380.41554049
130MAP2K40.39078464
131IGF1R0.38645256
132LCK0.38578980
133MAPK80.38426189
134PRKCQ0.38103693
135MATK0.37673715
136PRKD10.37610544
137MARK30.36888260
138PDGFRB0.36800830
139CAMK40.35164986
140STK40.35009373
141IRAK40.33727406
142MAP3K60.32414915

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.25972261
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.88415503
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.33903870
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.13541487
5Fatty acid degradation_Homo sapiens_hsa000713.07559535
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.95670357
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.80016993
8Propanoate metabolism_Homo sapiens_hsa006402.76204967
9Nitrogen metabolism_Homo sapiens_hsa009102.75391769
10Tryptophan metabolism_Homo sapiens_hsa003802.69783907
11Arginine biosynthesis_Homo sapiens_hsa002202.56196554
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.51794443
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.48676138
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24198839
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.23126834
16Fatty acid metabolism_Homo sapiens_hsa012122.22319412
17Complement and coagulation cascades_Homo sapiens_hsa046102.22105718
18Butanoate metabolism_Homo sapiens_hsa006502.19979864
19Peroxisome_Homo sapiens_hsa041462.18505076
20PPAR signaling pathway_Homo sapiens_hsa033202.10571923
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.94738984
22beta-Alanine metabolism_Homo sapiens_hsa004101.86695220
23Notch signaling pathway_Homo sapiens_hsa043301.84907501
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.77690208
25Pyruvate metabolism_Homo sapiens_hsa006201.70897064
26Carbon metabolism_Homo sapiens_hsa012001.65104067
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.61370914
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.57964000
29Chemical carcinogenesis_Homo sapiens_hsa052041.57308721
30Histidine metabolism_Homo sapiens_hsa003401.55319432
31Caffeine metabolism_Homo sapiens_hsa002321.54293902
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53701833
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.53148462
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49993026
35Retinol metabolism_Homo sapiens_hsa008301.45555400
36Selenocompound metabolism_Homo sapiens_hsa004501.45196871
37Phenylalanine metabolism_Homo sapiens_hsa003601.45044800
38Starch and sucrose metabolism_Homo sapiens_hsa005001.42202441
39Staphylococcus aureus infection_Homo sapiens_hsa051501.40841876
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37071131
41Osteoclast differentiation_Homo sapiens_hsa043801.36909071
42VEGF signaling pathway_Homo sapiens_hsa043701.36332151
43Fatty acid elongation_Homo sapiens_hsa000621.35202656
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35015273
45Biosynthesis of amino acids_Homo sapiens_hsa012301.32813625
46Folate biosynthesis_Homo sapiens_hsa007901.30985619
47Tyrosine metabolism_Homo sapiens_hsa003501.27665134
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26491366
49ABC transporters_Homo sapiens_hsa020101.26122471
50Bile secretion_Homo sapiens_hsa049761.22812555
51Leishmaniasis_Homo sapiens_hsa051401.20818151
52Lysosome_Homo sapiens_hsa041421.20477728
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.18636775
54Fat digestion and absorption_Homo sapiens_hsa049751.15703056
55mTOR signaling pathway_Homo sapiens_hsa041501.09403323
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.08378935
57Lysine degradation_Homo sapiens_hsa003101.08229842
58Sulfur metabolism_Homo sapiens_hsa009201.07527639
59GnRH signaling pathway_Homo sapiens_hsa049121.06232802
60Allograft rejection_Homo sapiens_hsa053301.03583794
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03576581
62Cyanoamino acid metabolism_Homo sapiens_hsa004601.02769380
63NF-kappa B signaling pathway_Homo sapiens_hsa040641.02055420
64Sulfur relay system_Homo sapiens_hsa041221.01908129
65TNF signaling pathway_Homo sapiens_hsa046681.01075773
66T cell receptor signaling pathway_Homo sapiens_hsa046601.00944915
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00219173
68Choline metabolism in cancer_Homo sapiens_hsa052310.98840644
69Vitamin digestion and absorption_Homo sapiens_hsa049770.98535073
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93234345
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93151781
72Autoimmune thyroid disease_Homo sapiens_hsa053200.92853805
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.90055275
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88845728
75Non-small cell lung cancer_Homo sapiens_hsa052230.87426352
76Toxoplasmosis_Homo sapiens_hsa051450.86980272
77Glycerolipid metabolism_Homo sapiens_hsa005610.86334930
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.85946645
79Arginine and proline metabolism_Homo sapiens_hsa003300.85821588
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.85772816
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83356007
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82916287
83Asthma_Homo sapiens_hsa053100.82617685
84Graft-versus-host disease_Homo sapiens_hsa053320.82600780
85One carbon pool by folate_Homo sapiens_hsa006700.81185283
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80851327
87Chronic myeloid leukemia_Homo sapiens_hsa052200.78108862
88Pentose phosphate pathway_Homo sapiens_hsa000300.76022230
89Tuberculosis_Homo sapiens_hsa051520.75023215
90Influenza A_Homo sapiens_hsa051640.73180207
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71200245
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70864090
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70098079
94Platelet activation_Homo sapiens_hsa046110.69315748
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66807130
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.66638375
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63311786
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59637989
99Fructose and mannose metabolism_Homo sapiens_hsa000510.59167278
100Prolactin signaling pathway_Homo sapiens_hsa049170.57873476
101Inositol phosphate metabolism_Homo sapiens_hsa005620.57574934
102Glutathione metabolism_Homo sapiens_hsa004800.57234837
103Vitamin B6 metabolism_Homo sapiens_hsa007500.56943133
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.55993664
105Fatty acid biosynthesis_Homo sapiens_hsa000610.55731845
106Insulin resistance_Homo sapiens_hsa049310.54822990
107Bladder cancer_Homo sapiens_hsa052190.54480800
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53097122
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.49334256
110Steroid biosynthesis_Homo sapiens_hsa001000.48380271
111Metabolic pathways_Homo sapiens_hsa011000.48322045
112Hepatitis B_Homo sapiens_hsa051610.47978640
113Estrogen signaling pathway_Homo sapiens_hsa049150.47734070
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46853995
115Herpes simplex infection_Homo sapiens_hsa051680.46214937
116Type I diabetes mellitus_Homo sapiens_hsa049400.46066420
117Amoebiasis_Homo sapiens_hsa051460.44782615
118Galactose metabolism_Homo sapiens_hsa000520.42399420
119Chemokine signaling pathway_Homo sapiens_hsa040620.41848919
120MAPK signaling pathway_Homo sapiens_hsa040100.41535318
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39152717
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28530185
123AMPK signaling pathway_Homo sapiens_hsa041520.22554788
124Glucagon signaling pathway_Homo sapiens_hsa049220.21722616
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14000742
126Insulin signaling pathway_Homo sapiens_hsa049100.10890290
127Primary immunodeficiency_Homo sapiens_hsa053400.07060075
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.06190378
129Linoleic acid metabolism_Homo sapiens_hsa005910.03262892
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.02915833
131B cell receptor signaling pathway_Homo sapiens_hsa046620.00943153
132Jak-STAT signaling pathway_Homo sapiens_hsa04630-0.1632948
133Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.1620619
134Measles_Homo sapiens_hsa05162-0.1595602
135Pertussis_Homo sapiens_hsa05133-0.1589373
136Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1547715
137Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.1528421
138Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1368587
139Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1346137
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.1305940
141Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1207521
142RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0703454
143Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0554565
144Legionellosis_Homo sapiens_hsa05134-0.0424501
145Acute myeloid leukemia_Homo sapiens_hsa05221-0.0408453
146Hepatitis C_Homo sapiens_hsa05160-0.0326585
147Prion diseases_Homo sapiens_hsa05020-0.0207336
148Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0141905
149Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0090005

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