CYTL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: C17 is a cytokine-like protein specifically expressed in bone marrow and cord blood mononuclear cells that bear the CD34 (MIM 142230) surface marker (Liu et al., 2000 [PubMed 10857752]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T-helper 1 cell differentiation (GO:0045625)8.84618381
2positive regulation of antigen processing and presentation (GO:0002579)8.14919610
3cellular protein complex localization (GO:0034629)7.57036654
4response to nitric oxide (GO:0071731)7.43995079
5positive regulation of Cdc42 GTPase activity (GO:0043089)6.76188457
6positive regulation of glycoprotein biosynthetic process (GO:0010560)6.73581303
7definitive hemopoiesis (GO:0060216)6.51828136
8regulation of antigen processing and presentation (GO:0002577)6.47694109
9striated muscle atrophy (GO:0014891)6.35133106
10positive regulation of granulocyte chemotaxis (GO:0071624)6.26057655
11positive regulation of T-helper 1 type immune response (GO:0002827)6.10799401
12skeletal muscle adaptation (GO:0043501)5.97994175
13muscle atrophy (GO:0014889)5.94671977
14response to prostaglandin E (GO:0034695)5.79604691
15aggressive behavior (GO:0002118)5.78851992
16positive regulation of glycoprotein metabolic process (GO:1903020)5.73462659
17positive regulation of T-helper cell differentiation (GO:0045624)5.71594070
18negative regulation of muscle hypertrophy (GO:0014741)5.66027740
19positive regulation of neutrophil chemotaxis (GO:0090023)5.62463905
20positive regulation of neutrophil migration (GO:1902624)5.62463905
21pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.61784318
22leukocyte tethering or rolling (GO:0050901)5.47527030
23synapsis (GO:0007129)5.36532082
24ribosomal small subunit assembly (GO:0000028)5.33491158
25skeletal muscle tissue regeneration (GO:0043403)5.26621713
26imidazole-containing compound metabolic process (GO:0052803)5.25454334
27positive regulation of B cell differentiation (GO:0045579)5.24724915
28response to gravity (GO:0009629)5.23576658
29synaptic vesicle maturation (GO:0016188)5.18914403
30endothelium development (GO:0003158)4.81295641
31heterotypic cell-cell adhesion (GO:0034113)4.64942622
32protein complex localization (GO:0031503)4.60665084
33dendritic cell chemotaxis (GO:0002407)4.60307314
34collecting duct development (GO:0072044)4.57404611
35deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.53778806
36pyrimidine nucleotide catabolic process (GO:0006244)4.48608876
37regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)4.47055530
38deoxyribonucleotide catabolic process (GO:0009264)4.44004470
39response to prostaglandin (GO:0034694)4.43674492
40positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)4.34968775
41negative regulation of skeletal muscle tissue development (GO:0048642)4.34370736
42positive regulation of interleukin-1 beta secretion (GO:0050718)4.30753845
43phosphate ion homeostasis (GO:0055062)4.28084557
44trivalent inorganic anion homeostasis (GO:0072506)4.28084557
45negative regulation of erythrocyte differentiation (GO:0045647)4.27690822
46response to muscle activity (GO:0014850)4.27648697
47positive regulation of insulin receptor signaling pathway (GO:0046628)4.24350150
48renal absorption (GO:0070293)4.24062663
49ovulation from ovarian follicle (GO:0001542)4.22419136
50regulation of T-helper 1 type immune response (GO:0002825)4.20324787
51deoxyribose phosphate catabolic process (GO:0046386)4.18351748
52single strand break repair (GO:0000012)4.17891143
53positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.13441215
54purine nucleotide salvage (GO:0032261)4.10613050
55regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.99884795
56regulation of neutrophil chemotaxis (GO:0090022)3.99304765
57regulation of neutrophil migration (GO:1902622)3.99304765
58DNA strand renaturation (GO:0000733)3.99152055
59positive regulation of interleukin-1 secretion (GO:0050716)3.99119776
60keratan sulfate catabolic process (GO:0042340)3.94576950
61cellular anion homeostasis (GO:0030002)3.93189758
62positive regulation of NF-kappaB import into nucleus (GO:0042346)3.92465787
63positive regulation of DNA-templated transcription, initiation (GO:2000144)3.92399128
64DNA deamination (GO:0045006)3.92006092
65purine deoxyribonucleotide catabolic process (GO:0009155)3.91287978
66positive regulation of megakaryocyte differentiation (GO:0045654)3.91263765
67pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.90003238
68aorta morphogenesis (GO:0035909)3.89017063
69seminiferous tubule development (GO:0072520)3.88986735
70positive regulation of urine volume (GO:0035810)3.88154629
71mature B cell differentiation involved in immune response (GO:0002313)3.86347792
72base-excision repair, AP site formation (GO:0006285)3.84431417
73regulation of T-helper cell differentiation (GO:0045622)3.80279297
74regulation of bile acid biosynthetic process (GO:0070857)3.79861063
75dendritic cell differentiation (GO:0097028)3.78138554
76positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)3.77422654
77detection of bacterium (GO:0016045)3.75700092
78regulation of interleukin-1 beta secretion (GO:0050706)3.74365701
79negative regulation of B cell apoptotic process (GO:0002903)3.73781598
80hyperosmotic salinity response (GO:0042538)3.69668798
81regulation of granulocyte chemotaxis (GO:0071622)3.65011325
82regulation of female receptivity (GO:0045924)3.64286326
83positive regulation of lipid kinase activity (GO:0090218)3.63557506
84protoporphyrinogen IX biosynthetic process (GO:0006782)3.60237760
85regulation of B cell apoptotic process (GO:0002902)3.57753448
86grooming behavior (GO:0007625)3.56717499
87regulation of Cdc42 GTPase activity (GO:0043088)3.54669503
88Peyers patch development (GO:0048541)3.52335778
89mucosal-associated lymphoid tissue development (GO:0048537)3.52335778
90renal tubule development (GO:0061326)3.48222773
91response to interferon-beta (GO:0035456)3.46953111
92pseudouridine synthesis (GO:0001522)3.46857079
93immunoglobulin mediated immune response (GO:0016064)3.46005771
94positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.44883125
95positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.43447458
96regulation of interleukin-1 secretion (GO:0050704)3.42828286
97lateral ventricle development (GO:0021670)3.42766401
98detection of other organism (GO:0098543)3.42304121
99positive regulation of interleukin-1 beta production (GO:0032731)3.38770453
100female mating behavior (GO:0060180)3.36762103
101regulation of muscle hypertrophy (GO:0014743)3.32013830
102purine-containing compound salvage (GO:0043101)3.29681677
103ribosomal large subunit biogenesis (GO:0042273)3.28992250
104skin development (GO:0043588)3.28954539
105viral transcription (GO:0019083)3.28272790
106Arp2/3 complex-mediated actin nucleation (GO:0034314)3.28087049
107oogenesis (GO:0048477)3.25659669
108translational termination (GO:0006415)3.23092187
109dendritic cell migration (GO:0036336)3.22923227
110regulation of B cell differentiation (GO:0045577)3.20925601
111cytokine secretion (GO:0050663)3.20852148
112protoporphyrinogen IX metabolic process (GO:0046501)3.18302979
113fatty acid homeostasis (GO:0055089)3.18231611
1142-deoxyribonucleotide metabolic process (GO:0009394)3.15400189
115positive regulation of granulocyte differentiation (GO:0030854)3.14938043
116peptide catabolic process (GO:0043171)3.13169096
117potassium ion homeostasis (GO:0055075)3.12185647
118collagen fibril organization (GO:0030199)3.10777820
119thrombin receptor signaling pathway (GO:0070493)3.09478009
120positive regulation of vasculogenesis (GO:2001214)3.05516267
121B cell mediated immunity (GO:0019724)3.04895805
122positive regulation of prostaglandin secretion (GO:0032308)3.03274243
123nephron tubule development (GO:0072080)3.01248669
124positive regulation of cellular response to insulin stimulus (GO:1900078)3.00731530
125regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.00695455
126positive regulation of interleukin-1 production (GO:0032732)2.99215960
127regulation of erythrocyte differentiation (GO:0045646)2.98725415
128translational elongation (GO:0006414)2.98671038
129regulation of penile erection (GO:0060405)2.98558286
130sympathetic nervous system development (GO:0048485)2.97958371
131negative regulation of fatty acid biosynthetic process (GO:0045717)2.97926139
132sleep (GO:0030431)2.97025012
133regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)2.96631906
134negative regulation of nitric oxide biosynthetic process (GO:0045019)2.96397648
135cyclooxygenase pathway (GO:0019371)2.95852787
136branched-chain amino acid metabolic process (GO:0009081)2.95704161
137iron-sulfur cluster assembly (GO:0016226)2.95609495
138metallo-sulfur cluster assembly (GO:0031163)2.95609495
139cellular response to dexamethasone stimulus (GO:0071549)2.93761066
140branched-chain amino acid catabolic process (GO:0009083)2.93658749
141deoxyribose phosphate metabolic process (GO:0019692)2.92884591
142negative regulation of interleukin-8 production (GO:0032717)2.91819152
143autophagic vacuole fusion (GO:0000046)2.91714848
144cellular response to interferon-beta (GO:0035458)2.91184207
145UV protection (GO:0009650)2.89789987
146positive regulation of cholesterol efflux (GO:0010875)2.87858739
147pinocytosis (GO:0006907)2.87350618
148positive regulation of interleukin-12 production (GO:0032735)2.86624776
149valine metabolic process (GO:0006573)2.85848777
150vocalization behavior (GO:0071625)2.85694675
151negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.80569856
152regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.80490463
153positive regulation of leukocyte migration (GO:0002687)2.80332780
154negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.80294814
155positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.78806966
156actin nucleation (GO:0045010)2.77940643
157nucleotide salvage (GO:0043173)2.77826890
158epithelial cell differentiation involved in kidney development (GO:0035850)2.77547864
159acrosome assembly (GO:0001675)2.75711932
160negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.74582455
161response to dexamethasone (GO:0071548)2.74552886
162heme biosynthetic process (GO:0006783)2.74389266
163maturation of SSU-rRNA (GO:0030490)2.73847761
164regulation of urine volume (GO:0035809)2.71543225
165striated muscle adaptation (GO:0014888)2.71377498
166histamine secretion (GO:0001821)2.71214549
167endothelial cell morphogenesis (GO:0001886)2.70849538
168protein complex biogenesis (GO:0070271)2.69196040
169regulation of natural killer cell differentiation (GO:0032823)2.69092391
170cellular response to exogenous dsRNA (GO:0071360)2.67472711
171bundle of His cell to Purkinje myocyte communication (GO:0086069)2.66645500
172mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.61178545
173mitochondrial respiratory chain complex I assembly (GO:0032981)2.61178545
174NADH dehydrogenase complex assembly (GO:0010257)2.61178545
175tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.59363686
176RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.59363686
177deoxyribonucleotide metabolic process (GO:0009262)2.59299923
178mature B cell differentiation (GO:0002335)2.58393132
179purine nucleobase metabolic process (GO:0006144)2.58233925
180SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.56236333
181purine deoxyribonucleotide metabolic process (GO:0009151)2.54785211
182regulation of megakaryocyte differentiation (GO:0045652)2.53706700
183mitochondrial respiratory chain complex assembly (GO:0033108)2.53547489
184positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.52950547
185nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.52116303
186exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.50563242
187regulation of histone H3-K9 methylation (GO:0051570)2.50334946
188deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.49535729
189blood vessel maturation (GO:0001955)2.48070823
190positive regulation of histone H3-K4 methylation (GO:0051571)2.47398622
191cotranslational protein targeting to membrane (GO:0006613)2.46597541
192DNA dealkylation (GO:0035510)2.46442134
193positive regulation of T cell differentiation in thymus (GO:0033089)2.46412818
194positive regulation of gamma-delta T cell activation (GO:0046645)2.45963708
195megakaryocyte development (GO:0035855)2.45308296
196positive thymic T cell selection (GO:0045059)2.43893902
197protein targeting to ER (GO:0045047)2.43693680
198regulation of dendritic cell antigen processing and presentation (GO:0002604)12.1703525

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.38106312
2SCL_19346495_ChIP-Seq_HPC-7_Human4.63482728
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.69463045
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.36608158
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.81199827
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.74797036
7LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.70590947
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.68309732
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.55573267
10DROSHA_22980978_ChIP-Seq_HELA_Human2.55305025
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42808937
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.38889018
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35570528
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33898880
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.33713716
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.30722957
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.28669440
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.21018003
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.18775112
20TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.17631613
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13491715
22VDR_23849224_ChIP-Seq_CD4+_Human2.08802758
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08511476
24FOXP3_21729870_ChIP-Seq_TREG_Human2.08354418
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08329056
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05242161
27LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.99480667
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.99294232
29CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.96815673
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.96772463
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96646366
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.96593163
33IGF1R_20145208_ChIP-Seq_DFB_Human1.93822565
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.91146333
35E2F7_22180533_ChIP-Seq_HELA_Human1.90302244
36SPI1_23547873_ChIP-Seq_NB4_Human1.89594824
37VDR_22108803_ChIP-Seq_LS180_Human1.86454225
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.84983522
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84349571
40GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.81864291
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.81132502
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.80271672
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80101446
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.79965236
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.79155532
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75971437
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.73890044
48MYB_26560356_Chip-Seq_TH2_Human1.73671666
49TBX20_22080862_ChIP-Seq_HEART_Mouse1.71212392
50TBX20_22328084_ChIP-Seq_HEART_Mouse1.71212392
51VDR_21846776_ChIP-Seq_THP-1_Human1.67001607
52GATA1_22025678_ChIP-Seq_K562_Human1.61451492
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60147032
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59070652
55TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.57344678
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.57249432
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56925869
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56691557
59ESR1_15608294_ChIP-ChIP_MCF-7_Human1.56154759
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.54273572
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.54041164
62STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53315762
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52333670
64BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.51292195
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50327480
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.50203519
67EZH2_18974828_ChIP-Seq_MESCs_Mouse1.50203519
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.49656114
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47077873
70CLOCK_20551151_ChIP-Seq_293T_Human1.46984124
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46741557
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.46199509
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45232157
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44835525
75CIITA_25753668_ChIP-Seq_RAJI_Human1.44399833
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.44364099
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.43845055
78SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42172789
79ZNF274_21170338_ChIP-Seq_K562_Hela1.40662307
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38135859
81IRF8_21731497_ChIP-ChIP_J774_Mouse1.38130625
82TP53_18474530_ChIP-ChIP_U2OS_Human1.37967658
83BCL6_27268052_Chip-Seq_Bcells_Human1.37186893
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37164066
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36872673
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36714500
87VDR_24763502_ChIP-Seq_THP-1_Human1.36394917
88CREB1_15753290_ChIP-ChIP_HEK293T_Human1.36380322
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35766041
90JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35621884
91GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34878746
92CJUN_26792858_Chip-Seq_BT549_Human1.34442242
93MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33751343
94NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.33383749
95SOX2_20726797_ChIP-Seq_SW620_Human1.32166255
96TCF4_18268006_ChIP-ChIP_LS174T_Human1.32149094
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31955955
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31321086
99STAT1_20625510_ChIP-Seq_HELA_Human1.31037665
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30109165
101AR_21572438_ChIP-Seq_LNCaP_Human1.27792513
102SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27644440
103JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26991617
104ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26532507
105EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25582800
106MYC_22102868_ChIP-Seq_BL_Human1.25056661
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24214799
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22650290
109GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22575449
110TTF2_22483619_ChIP-Seq_HELA_Human1.21088888
111FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20751566
112* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19345433
113FOXO3_23340844_ChIP-Seq_DLD1_Human1.18604205
114VDR_24787735_ChIP-Seq_THP-1_Human1.18459612
115BCAT_22108803_ChIP-Seq_LS180_Human1.18176152
116FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18109899
117CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17721757
118EZH2_27304074_Chip-Seq_ESCs_Mouse1.17368166
119CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17119786
120MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16967230
121SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16572094
122AHR_22903824_ChIP-Seq_MCF-7_Human1.16487233
123YY1_22570637_ChIP-Seq_MALME-3M_Human1.14072671
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13549484
125WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13395494
126E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12737305
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12365645
128NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12365645
129CTCF_26484167_Chip-Seq_Bcells_Mouse1.11958144
130GABP_19822575_ChIP-Seq_HepG2_Human1.11593636
131CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10719403
132FOXA2_19822575_ChIP-Seq_HepG2_Human1.10717074
133MYC_19079543_ChIP-ChIP_MESCs_Mouse1.10588821
134MYC_18940864_ChIP-ChIP_HL60_Human1.09325732
135ARNT_22903824_ChIP-Seq_MCF-7_Human1.08005096
136SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07636035
137EGR1_19374776_ChIP-ChIP_THP-1_Human1.07551718
138P300_27268052_Chip-Seq_Bcells_Human1.07063112
139CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06534072
140RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06218991
141SPI1_20517297_ChIP-Seq_HL60_Human1.05476862
142MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04210962
143EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03748122
144GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03610934
145RNF2_27304074_Chip-Seq_ESCs_Mouse1.03318502
146TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02911795
147CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02707091
148GATA3_26560356_Chip-Seq_TH2_Human1.02638736
149GATA1_19941827_ChIP-Seq_MEL_Mouse1.01494600
150CDX2_22108803_ChIP-Seq_LS180_Human1.01392063
151* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00917774
152ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.00604695
153MYB_26560356_Chip-Seq_TH1_Human1.00417849
154IRF1_19129219_ChIP-ChIP_H3396_Human0.97911255
155RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97552631
156STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97517847
157PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97226459
158RUNX1_22412390_ChIP-Seq_EML_Mouse0.96578350
159CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95072228
160XRN2_22483619_ChIP-Seq_HELA_Human0.95039362
161SUZ12_27294783_Chip-Seq_ESCs_Mouse0.92930564
162GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92772580
163FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92473748
164ELK1_19687146_ChIP-ChIP_HELA_Human0.91843341
165RUNX1_27514584_Chip-Seq_MCF-7_Human0.91598330
166EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91569111
167* ISL1_27105846_Chip-Seq_CPCs_Mouse0.91449871
168PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91126940
169SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90977020
170SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90857498
171PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90736905
172TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90718979
173NANOG_20526341_ChIP-Seq_ESCs_Human0.90702079
174EZH2_27294783_Chip-Seq_ESCs_Mouse0.90399890
175* GATA1_19941826_ChIP-Seq_K562_Human0.89957258
176AR_25329375_ChIP-Seq_VCAP_Human0.89333619
177SMAD3_21741376_ChIP-Seq_EPCs_Human0.89022051
178SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.88863932
179SOX2_21211035_ChIP-Seq_LN229_Gbm0.88763098
180TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88552047
181TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87976553
182POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87976553
183* GATA2_19941826_ChIP-Seq_K562_Human0.87270380
184RUNX1_26923725_Chip-Seq_HPCs_Mouse0.87001157
185IRF8_22096565_ChIP-ChIP_GC-B_Human0.86507050
186CTCF_27219007_Chip-Seq_Bcells_Human0.86433623
187SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86044943
188ERG_21242973_ChIP-ChIP_JURKAT_Human0.85124857
189STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.85118581
190PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83558811
191MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83460247
192SMC1_22415368_ChIP-Seq_MEFs_Mouse0.83092260

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system4.86174648
2MP0005503_abnormal_tendon_morphology4.67469094
3MP0001545_abnormal_hematopoietic_system4.19254035
4MP0005397_hematopoietic_system_phenotyp4.19254035
5MP0002876_abnormal_thyroid_physiology4.17820399
6MP0002254_reproductive_system_inflammat4.06367169
7MP0005647_abnormal_sex_gland3.78637908
8MP0005275_abnormal_skin_tensile3.73119939
9MP0009278_abnormal_bone_marrow3.57392461
10MP0005464_abnormal_platelet_physiology3.52517101
11MP0002396_abnormal_hematopoietic_system3.47566425
12MP0002160_abnormal_reproductive_system3.45914250
13MP0008438_abnormal_cutaneous_collagen3.29947605
14MP0003806_abnormal_nucleotide_metabolis3.10220591
15MP0000465_gastrointestinal_hemorrhage3.06499932
16MP0004808_abnormal_hematopoietic_stem3.01101300
17MP0006054_spinal_hemorrhage2.86235997
18MP0004510_myositis2.81472238
19MP0002132_abnormal_respiratory_system2.80114892
20MP0002138_abnormal_hepatobiliary_system2.77297507
21MP0005646_abnormal_pituitary_gland2.73910733
22MP0004147_increased_porphyrin_level2.71756774
23MP0002108_abnormal_muscle_morphology2.57388576
24MP0001348_abnormal_lacrimal_gland2.55307840
25MP0002089_abnormal_postnatal_growth/wei2.53591250
26MP0003656_abnormal_erythrocyte_physiolo2.43148925
27MP0001346_abnormal_lacrimal_gland2.41734593
28MP0001958_emphysema2.40051667
29MP0000751_myopathy2.30427040
30MP0002148_abnormal_hypersensitivity_rea2.28800070
31MP0005645_abnormal_hypothalamus_physiol2.25483226
32MP0004272_abnormal_basement_membrane2.21766354
33MP0008058_abnormal_DNA_repair2.11487761
34MP0003279_aneurysm1.99051022
35MP0004134_abnormal_chest_morphology1.97193061
36MP0003186_abnormal_redox_activity1.97057406
37MP0003718_maternal_effect1.94197213
38MP0002102_abnormal_ear_morphology1.92639279
39MP0003828_pulmonary_edema1.88572491
40MP0000566_synostosis1.87360742
41MP0009697_abnormal_copulation1.86842295
42MP0002837_dystrophic_cardiac_calcinosis1.83193580
43MP0008057_abnormal_DNA_replication1.83151252
44MP0003724_increased_susceptibility_to1.82537689
45MP0005084_abnormal_gallbladder_morpholo1.76577258
46MP0004036_abnormal_muscle_relaxation1.75320643
47MP0001873_stomach_inflammation1.71214149
48MP0006036_abnormal_mitochondrial_physio1.71094129
49MP0003436_decreased_susceptibility_to1.69471417
50MP0004084_abnormal_cardiac_muscle1.69157982
51MP0005075_abnormal_melanosome_morpholog1.66278351
52MP0003303_peritoneal_inflammation1.60792124
53MP0005000_abnormal_immune_tolerance1.57444963
54MP0002398_abnormal_bone_marrow1.55673881
55MP0000689_abnormal_spleen_morphology1.51472500
56MP0003045_fibrosis1.50350404
57MP0002735_abnormal_chemical_nociception1.46838702
58MP0003705_abnormal_hypodermis_morpholog1.46614633
59MP0009764_decreased_sensitivity_to1.45852277
60MP0002896_abnormal_bone_mineralization1.44270800
61MP0000003_abnormal_adipose_tissue1.43992673
62MP0002282_abnormal_trachea_morphology1.41577497
63MP0000681_abnormal_thyroid_gland1.38202363
64MP0005389_reproductive_system_phenotype1.36746731
65MP0005330_cardiomyopathy1.34133987
66MP0000516_abnormal_urinary_system1.33093109
67MP0005367_renal/urinary_system_phenotyp1.33093109
68MP0006292_abnormal_olfactory_placode1.33069773
69MP0002722_abnormal_immune_system1.30616097
70MP0005508_abnormal_skeleton_morphology1.29340155
71MP0001299_abnormal_eye_distance/1.27040985
72MP0002106_abnormal_muscle_physiology1.26201232
73MP0006138_congestive_heart_failure1.25893011
74MP0005025_abnormal_response_to1.25645624
75MP0002452_abnormal_antigen_presenting1.25070232
76MP0005369_muscle_phenotype1.24253294
77MP0003959_abnormal_lean_body1.23757331
78MP0002420_abnormal_adaptive_immunity1.23559434
79MP0001764_abnormal_homeostasis1.23368092
80MP0005410_abnormal_fertilization1.22384910
81MP0000230_abnormal_systemic_arterial1.21910390
82MP0002019_abnormal_tumor_incidence1.21897964
83MP0002419_abnormal_innate_immunity1.21513961
84MP0001819_abnormal_immune_cell1.21411094
85MP0001800_abnormal_humoral_immune1.21035386
86MP0002723_abnormal_immune_serum1.20487262
87MP0002429_abnormal_blood_cell1.20155144
88MP0005385_cardiovascular_system_phenoty1.19412705
89MP0001544_abnormal_cardiovascular_syste1.19412705
90MP0003866_abnormal_defecation1.18784600
91MP0001835_abnormal_antigen_presentation1.18337625
92MP0003075_altered_response_to1.16816822
93MP0000716_abnormal_immune_system1.16273825
94MP0008007_abnormal_cellular_replicative1.15897164
95MP0004087_abnormal_muscle_fiber1.15406322
96MP0002269_muscular_atrophy1.14727867
97MP0002971_abnormal_brown_adipose1.13705958
98MP0003566_abnormal_cell_adhesion1.12485661
99MP0009379_abnormal_foot_pigmentation1.11179653
100MP0008004_abnormal_stomach_pH1.10374040
101MP0000579_abnormal_nail_morphology1.10165034
102MP0008875_abnormal_xenobiotic_pharmacok1.09939110
103MP0000163_abnormal_cartilage_morphology1.09874142
104MP0002060_abnormal_skin_morphology1.08754580
105MP0008872_abnormal_physiological_respon1.07132935
106MP0005165_increased_susceptibility_to1.06666958
107MP0010368_abnormal_lymphatic_system1.06164329
108MP0002405_respiratory_system_inflammati1.04386306
109MP0002972_abnormal_cardiac_muscle1.03091787
110MP0009333_abnormal_splenocyte_physiolog1.02701281
111MP0005310_abnormal_salivary_gland1.02107739
112MP0003879_abnormal_hair_cell1.00865717
113MP0000749_muscle_degeneration1.00820618
114MP0000372_irregular_coat_pigmentation0.98605660
115MP0000767_abnormal_smooth_muscle0.98579164
116MP0003646_muscle_fatigue0.97991885
117MP0002249_abnormal_larynx_morphology0.97957636
118MP0002133_abnormal_respiratory_system0.97256896
119MP0005388_respiratory_system_phenotype0.97256896
120MP0005220_abnormal_exocrine_pancreas0.97131471
121MP0002796_impaired_skin_barrier0.97067627
122MP0009765_abnormal_xenobiotic_induced0.96371260
123MP0003763_abnormal_thymus_physiology0.95024973
124MP0008469_abnormal_protein_level0.94282806
125MP0008873_increased_physiological_sensi0.93814370
126MP0003191_abnormal_cellular_cholesterol0.93164459
127MP0003787_abnormal_imprinting0.92922477
128MP0005334_abnormal_fat_pad0.92708531
129MP0003300_gastrointestinal_ulcer0.92326435
130MP0002115_abnormal_skeleton_extremities0.92310908
131MP0005387_immune_system_phenotype0.91278342
132MP0001790_abnormal_immune_system0.91278342
133MP0006035_abnormal_mitochondrial_morpho0.89892667
134MP0001664_abnormal_digestion0.89001648
135MP0003172_abnormal_lysosome_physiology0.88407658
136MP0002928_abnormal_bile_duct0.86565917
137MP0001986_abnormal_taste_sensitivity0.85450947
138MP0006082_CNS_inflammation0.83992471
139MP0005620_abnormal_muscle_contractility0.83182210
140MP0004215_abnormal_myocardial_fiber0.82154889
141MP0000470_abnormal_stomach_morphology0.82145647
142MP0001533_abnormal_skeleton_physiology0.81999071
143MP0003137_abnormal_impulse_conducting0.81975495
144MP0005535_abnormal_body_temperature0.81793339
145MP0003567_abnormal_fetal_cardiomyocyte0.81159815
146MP0009643_abnormal_urine_homeostasis0.81053515
147MP0002295_abnormal_pulmonary_circulatio0.79965725
148MP0010094_abnormal_chromosome_stability0.79865758
149MP0009780_abnormal_chondrocyte_physiolo0.78123333
150MP0009763_increased_sensitivity_to0.77433711
151MP0005390_skeleton_phenotype0.77384684
152MP0008775_abnormal_heart_ventricle0.77167434
153MP0001881_abnormal_mammary_gland0.76723832
154MP0000015_abnormal_ear_pigmentation0.76670000
155MP0002006_tumorigenesis0.76652213
156MP0000049_abnormal_middle_ear0.76502422
157MP0002877_abnormal_melanocyte_morpholog0.76131180
158MP0002933_joint_inflammation0.75950130
159MP0000343_altered_response_to0.75678542
160MP0001663_abnormal_digestive_system0.75616594
161MP0008995_early_reproductive_senescence0.75324363
162MP0006072_abnormal_retinal_apoptosis0.74738716
163MP0004782_abnormal_surfactant_physiolog0.74589622
164MP0002009_preneoplasia0.74013874
165MP0005174_abnormal_tail_pigmentation0.73099104
166MP0005375_adipose_tissue_phenotype0.72694422
167MP0002168_other_aberrant_phenotype0.72477655
168MP0005636_abnormal_mineral_homeostasis0.70985760
169MP0009115_abnormal_fat_cell0.70700840
170MP0006276_abnormal_autonomic_nervous0.69362163
171MP0004145_abnormal_muscle_electrophysio0.68541233
172MP0002970_abnormal_white_adipose0.68164842
173MP0010155_abnormal_intestine_physiology0.67015465
174MP0003638_abnormal_response/metabolism_0.66710393
175MP0005319_abnormal_enzyme/_coenzyme0.66240541
176MP0009250_abnormal_appendicular_skeleto0.65154697
177MP0000759_abnormal_skeletal_muscle0.64934464
178MP0002932_abnormal_joint_morphology0.64149770
179MP0008877_abnormal_DNA_methylation0.64035417
180MP0002095_abnormal_skin_pigmentation0.63647388
181MP0001270_distended_abdomen0.61611444
182MP0001853_heart_inflammation0.61308053
183MP0003183_abnormal_peptide_metabolism0.60678125
184MP0003795_abnormal_bone_structure0.60603642
185MP0005164_abnormal_response_to0.60320516
186MP0005448_abnormal_energy_balance0.60173893
187MP0010630_abnormal_cardiac_muscle0.59356458
188MP0005670_abnormal_white_adipose0.59334798

Predicted human phenotypes

RankGene SetZ-score
1Hypoplastic ischia (HP:0003175)5.30595486
2Epiphyseal dysplasia (HP:0002656)5.04672050
3Abnormality of the heme biosynthetic pathway (HP:0010472)4.97010052
4Abnormality of the ischium (HP:0003174)4.62468576
5Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.23971967
6Prolonged bleeding time (HP:0003010)4.21859854
7Aplastic anemia (HP:0001915)4.21281595
8Panhypogammaglobulinemia (HP:0003139)4.11658113
9Elevated erythrocyte sedimentation rate (HP:0003565)3.98865266
10Symphalangism affecting the phalanges of the hand (HP:0009773)3.98438729
11Abnormality of the phalanges of the 5th finger (HP:0004213)3.89957850
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.84743962
13Abnormal number of erythroid precursors (HP:0012131)3.82733215
14Hyperglycemia (HP:0003074)3.79609471
15Increased IgE level (HP:0003212)3.69263726
16Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.66939418
17Thrombocytosis (HP:0001894)3.64350379
18Type I diabetes mellitus (HP:0100651)3.62766129
19Irregular epiphyses (HP:0010582)3.58861599
20Abnormality of cells of the erythroid lineage (HP:0012130)3.56554165
21Decreased electroretinogram (ERG) amplitude (HP:0000654)3.53943800
22Petechiae (HP:0000967)3.42395190
23Abnormality of B cell number (HP:0010975)3.40561858
24Short 5th finger (HP:0009237)3.37955350
25Muscle fiber splitting (HP:0003555)3.34455564
26Epistaxis (HP:0000421)3.33104925
27Decreased central vision (HP:0007663)3.32017244
28Bell-shaped thorax (HP:0001591)3.29730477
29Muscle fibrillation (HP:0010546)3.24968517
30Increased intramyocellular lipid droplets (HP:0012240)3.22974861
31Eczematoid dermatitis (HP:0000976)3.18172302
32Tongue fasciculations (HP:0001308)3.17061944
33Ventricular tachycardia (HP:0004756)3.13146291
34Hydroxyprolinuria (HP:0003080)3.11192530
35Abnormality of proline metabolism (HP:0010907)3.11192530
36Type I transferrin isoform profile (HP:0003642)3.10308729
37Acute lymphatic leukemia (HP:0006721)3.10285674
38Mesomelia (HP:0003027)3.09157209
39Tubulointerstitial fibrosis (HP:0005576)3.07545267
40Increased muscle lipid content (HP:0009058)3.07437622
41Dicarboxylic aciduria (HP:0003215)3.07273055
42Abnormality of dicarboxylic acid metabolism (HP:0010995)3.07273055
43Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.05663285
44Hepatocellular necrosis (HP:0001404)3.04310280
45Stomatitis (HP:0010280)3.03922778
46Flat capital femoral epiphysis (HP:0003370)2.97664949
47Autoimmune hemolytic anemia (HP:0001890)2.96030479
48Reticulocytopenia (HP:0001896)2.95003236
49Increased neuronal autofluorescent lipopigment (HP:0002074)2.94577834
50B lymphocytopenia (HP:0010976)2.94027664
51Small epiphyses (HP:0010585)2.90768858
52Cerebral palsy (HP:0100021)2.90594236
53Broad metatarsal (HP:0001783)2.89344421
54Protrusio acetabuli (HP:0003179)2.87910327
55Facial shape deformation (HP:0011334)2.87577171
56Potter facies (HP:0002009)2.87577171
57Keratoconjunctivitis (HP:0001096)2.84978371
58Enlarged kidneys (HP:0000105)2.84120721
59Hyperglycinemia (HP:0002154)2.81725169
60Abnormal glycosylation (HP:0012345)2.81354563
61Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.81354563
62Abnormal protein N-linked glycosylation (HP:0012347)2.81354563
63Abnormal protein glycosylation (HP:0012346)2.81354563
64Right ventricular cardiomyopathy (HP:0011663)2.80720449
65Pallor (HP:0000980)2.80170677
66Agammaglobulinemia (HP:0004432)2.77560825
67Abnormality of the prostate (HP:0008775)2.77445810
68Hepatic necrosis (HP:0002605)2.75446705
69Neonatal short-limb short stature (HP:0008921)2.73307054
70Fragile skin (HP:0001030)2.73017816
71Premature rupture of membranes (HP:0001788)2.72896275
72Pancytopenia (HP:0001876)2.71971836
73Increased connective tissue (HP:0009025)2.71714061
74Osteoarthritis (HP:0002758)2.69332157
75Abnormality of the pubic bones (HP:0003172)2.65996545
76Atrophic scars (HP:0001075)2.58508285
77Decreased activity of mitochondrial respiratory chain (HP:0008972)2.58492196
78Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.58492196
79Abnormal delayed hypersensitivity skin test (HP:0002963)2.58358984
80Cervical subluxation (HP:0003308)2.58139210
81Long clavicles (HP:0000890)2.58074090
82Mitochondrial inheritance (HP:0001427)2.57587011
83Abnormal rod and cone electroretinograms (HP:0008323)2.56793700
84Hypertensive crisis (HP:0100735)2.56234648
85Delayed epiphyseal ossification (HP:0002663)2.55823198
86Attenuation of retinal blood vessels (HP:0007843)2.54937360
87Chronic obstructive pulmonary disease (HP:0006510)2.54842056
88Obstructive lung disease (HP:0006536)2.54842056
89Vitreoretinal degeneration (HP:0000655)2.54769289
90Type 1 muscle fiber predominance (HP:0003803)2.54185809
91Reduced antithrombin III activity (HP:0001976)2.53282078
92Follicular hyperkeratosis (HP:0007502)2.52849282
93Mild short stature (HP:0003502)2.49903072
94Increased cerebral lipofuscin (HP:0011813)2.48770481
95Supernumerary nipples (HP:0002558)2.48271968
96Respiratory distress (HP:0002098)2.46173889
97Synostosis involving bones of the hand (HP:0004278)2.44383734
98Microvesicular hepatic steatosis (HP:0001414)2.43214628
99Protruding ear (HP:0000411)2.42139365
100Visual hallucinations (HP:0002367)2.41743320
101Ankle contracture (HP:0006466)2.41106665
102Abolished electroretinogram (ERG) (HP:0000550)2.39566141
103Neonatal death (HP:0003811)2.39451355
104Xerostomia (HP:0000217)2.39407869
105Stomach cancer (HP:0012126)2.38820915
106Autoimmune thrombocytopenia (HP:0001973)2.37326600
107Sudden death (HP:0001699)2.36264747
108Spontaneous abortion (HP:0005268)2.34247197
109Abnormal mitochondria in muscle tissue (HP:0008316)2.33235567
110Chronic otitis media (HP:0000389)2.31141292
111Abnormality of transition element cation homeostasis (HP:0011030)2.29043395
112Recurrent viral infections (HP:0004429)2.28195089
113Myositis (HP:0100614)2.23342880
114Hypercortisolism (HP:0001578)2.22731225
115Bundle branch block (HP:0011710)2.22284064
116Gingival bleeding (HP:0000225)2.21834013
117Flat acetabular roof (HP:0003180)2.20232462
118Vertebral compression fractures (HP:0002953)2.20155414
119Abnormality of T cell physiology (HP:0011840)2.19970187
120Rhabdomyolysis (HP:0003201)2.19447560
121Hyperglycinuria (HP:0003108)2.18703438
122Hyperammonemia (HP:0001987)2.16307423
123Recurrent fungal infections (HP:0002841)2.15736564
124Abnormality of iron homeostasis (HP:0011031)2.14268752
125Increased CSF lactate (HP:0002490)2.13662670
126Lipid accumulation in hepatocytes (HP:0006561)2.13143202
127Macrocytic anemia (HP:0001972)2.13101712
128Lactic acidosis (HP:0003128)2.12927862
129Lethargy (HP:0001254)2.12858983
130Wrist flexion contracture (HP:0001239)2.12368123
131Upper limb muscle weakness (HP:0003484)2.12352311
132Plantar hyperkeratosis (HP:0007556)2.12085738
133Acute encephalopathy (HP:0006846)2.12009957
134Myelodysplasia (HP:0002863)2.11657352
135Constricted visual fields (HP:0001133)2.11482358
136Cerebral edema (HP:0002181)2.11125614
137Abnormal pupillary function (HP:0007686)2.10187914
138Palmoplantar hyperkeratosis (HP:0000972)2.08595194
139Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.08005316
140Short 4th metacarpal (HP:0010044)2.08005316
141Methylmalonic aciduria (HP:0012120)2.06032842
142Cupped ribs (HP:0000887)2.04856179
143Tubulointerstitial nephritis (HP:0001970)2.03464656
144Aortic dissection (HP:0002647)2.02974338
145Stridor (HP:0010307)2.02939193
146Hematochezia (HP:0002573)2.02346522
147Exercise-induced muscle cramps (HP:0003710)2.01624187
148Ragged-red muscle fibers (HP:0003200)2.01330524
149Abnormal ossification of hand bones (HP:0005921)2.00179426
150Hyperthyroidism (HP:0000836)2.00140782
151Abnormality of the middle phalanges of the hand (HP:0009833)1.97489070
152Congenital stationary night blindness (HP:0007642)1.97337731
153Exostoses (HP:0100777)1.97291316
154Increased variability in muscle fiber diameter (HP:0003557)1.97239627
155Genu varum (HP:0002970)1.97122546
156Ketosis (HP:0001946)1.96424039
157Increased corneal curvature (HP:0100692)1.96373139
158Keratoconus (HP:0000563)1.96373139
159Abnormal hand bone ossification (HP:0010660)1.94822375
160Acute necrotizing encephalopathy (HP:0006965)1.94606439
161Seborrheic dermatitis (HP:0001051)1.93545900
162Limited hip movement (HP:0008800)1.93325412
163Flat cornea (HP:0007720)1.93071770
164Renal Fanconi syndrome (HP:0001994)1.91784931
165Abnormality of the 4th metacarpal (HP:0010012)1.91612498
166Increased serum lactate (HP:0002151)1.91411849
167Type 2 muscle fiber atrophy (HP:0003554)1.91099453
168Increased hepatocellular lipid droplets (HP:0006565)1.90313444
169Cerebral aneurysm (HP:0004944)1.90289440
170Platyspondyly (HP:0000926)1.90173556
171Failure to thrive in infancy (HP:0001531)1.88744327
172Shallow orbits (HP:0000586)1.88204677
173Brushfield spots (HP:0001088)1.87827552
174Abnormality of carpal bone ossification (HP:0006257)1.86430277
175Palmar hyperkeratosis (HP:0010765)1.85873885
176Interstitial pulmonary disease (HP:0006530)1.85767041
177Hip contracture (HP:0003273)1.85489010
178Increased serum ferritin (HP:0003281)1.85155106
179Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.85088823
180Abnormality of femoral epiphyses (HP:0006499)1.85088823
181Gingivitis (HP:0000230)1.84648581
182Dyschromatopsia (HP:0007641)1.84145539
183Small hand (HP:0200055)1.82775077
184Lumbar hyperlordosis (HP:0002938)1.82516544
185Purpura (HP:0000979)1.81959708
186Emotional lability (HP:0000712)1.81554860
187Mediastinal lymphadenopathy (HP:0100721)1.81209419
188Menorrhagia (HP:0000132)1.80954233
189Sprengel anomaly (HP:0000912)1.80374838
190Intellectual disability, mild (HP:0001256)1.79950588
191Broad nasal tip (HP:0000455)1.79404941
192Hyporeflexia of lower limbs (HP:0002600)1.78453855
193Neutropenia (HP:0001875)1.77633190
194Methylmalonic acidemia (HP:0002912)1.77502774
195Granulocytopenia (HP:0001913)1.77467711
196Milia (HP:0001056)1.76970337
197Diaphragmatic weakness (HP:0009113)1.75205138
198Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.74973115
199Recurrent gram-negative bacterial infections (HP:0005420)1.74972580
200Lipoatrophy (HP:0100578)1.74256180

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.22629901
2DYRK1B5.03848981
3TAOK34.55937181
4DYRK34.36452087
5NME23.45622834
6VRK23.30537167
7KIT3.05748313
8LATS13.04965257
9TTN2.88901363
10ERN12.86988622
11MAP3K142.80843787
12TIE12.47461159
13IRAK42.36955347
14PINK12.31995490
15ERBB32.27840664
16NEK92.19258292
17STK242.12905014
18PIM22.06228239
19SIK12.04514753
20MAP4K22.03635436
21TEC1.98549289
22PBK1.95878722
23LMTK21.87068064
24FES1.86080601
25FLT31.85498333
26BMPR21.74508911
27TESK21.73940076
28MAP4K11.70718619
29LATS21.70014213
30EIF2AK31.62389134
31VRK11.62078577
32BCR1.59634030
33MAP3K111.57461368
34STK38L1.53607819
35BTK1.52794036
36GRK11.52611039
37PDGFRA1.49211563
38MYLK1.47822156
39JAK31.46806348
40NTRK11.45112608
41EPHA31.42281778
42ADRBK21.41562440
43IKBKB1.37907576
44MKNK11.37339184
45TGFBR21.34518029
46SCYL21.32032314
47CCNB11.31139287
48PRKCQ1.30313672
49MATK1.27978399
50PLK21.26510621
51EPHB11.23603820
52ITK1.23316782
53LRRK21.23111484
54MAP2K31.20562776
55NME11.19785174
56RPS6KB21.19393500
57TRIB31.17994975
58ILK1.17686770
59CSF1R1.14021602
60ZAK1.13533143
61PDK31.09337507
62PDK41.09337507
63TLK11.08827340
64STK101.08324582
65IKBKE1.07349050
66MAPKAPK51.07156543
67BCKDK1.05343250
68OBSCN1.05215146
69DAPK11.03486530
70CDC42BPA1.01737756
71GRK61.01491859
72TXK0.97137942
73DYRK1A0.97010868
74ABL20.94740288
75MARK30.91868368
76CDK190.90659079
77STK160.88615388
78RPS6KA50.87241993
79PAK30.87128341
80CHUK0.86632116
81ROCK10.84143140
82PTK60.81653924
83TRPM70.80902247
84PHKG10.80738632
85PHKG20.80738632
86RPS6KC10.79051352
87RPS6KL10.79051352
88BMPR1B0.78951524
89RPS6KA60.78155676
90DMPK0.77684164
91CDK30.75719339
92FER0.74932624
93MAP2K20.74322980
94LYN0.73123369
95MAP3K70.71095617
96LCK0.68734650
97RIPK10.67992668
98FGFR20.66865442
99MAP3K10.66072600
100PRKCD0.63346752
101ROCK20.63021251
102PRKCE0.62860715
103SYK0.61722264
104ATR0.60288433
105RAF10.58786565
106MAPK150.58683860
107HCK0.58370357
108PIM10.58175943
109PDK20.58144696
110FGFR40.56667419
111PAK60.56503574
112CAMK1D0.55801123
113PKN20.55497024
114PRKD10.54733149
115PRKAA20.54696656
116PTK20.54535105
117TNK20.54416919
118FGFR30.54008310
119SIK30.53798416
120JAK10.53651055
121CSNK1G30.52162497
122NUAK10.51492849
123PKN10.51451136
124EPHB20.51268629
125PTK2B0.51130050
126MAPK30.51016018
127MAP3K60.50283223
128DAPK30.50058781
129MAP3K50.49776458
130AURKA0.49235549
131TAOK20.48323494
132INSRR0.48241201
133FGFR10.47402430
134CDC70.47232587
135MAPKAPK30.46776277
136GRK50.46576890
137PRKG20.45670664
138STK30.45149850
139MAP3K130.44346555
140EIF2AK10.43268359
141CDK80.42449475
142DAPK20.42173612
143IGF1R0.40848319
144ABL10.40574161
145CSNK1G20.40562740
146CHEK20.39964782
147TGFBR10.39252487
148PRKCH0.38821460
149NEK20.38406147
150IRAK10.37314554
151TBK10.37281102
152GRK70.36907729
153EIF2AK20.35141840
154ATM0.34826459
155CSNK1G10.34617040
156MAPK70.33024992
157FRK0.32794387
158ADRBK10.32537772
159SRC0.32314595
160MAP2K60.32203792
161MAP3K30.31982937
162CSNK2A20.31944843
163KDR0.31667652
164CSNK2A10.30839556
165RPS6KB10.30544391
166MAPK40.30041858
167JAK20.29133262
168CDK90.28927604
169ZAP700.28373673
170GSK3A0.27410815
171PIK3CG0.26996669
172MTOR0.24893300
173PRKCZ0.24374097
174EGFR0.22863913
175PAK20.22160872
176MAPK120.22007221
177TAOK10.21891004
178CAMK40.21872043
179CAMK2D0.21350768
180KSR10.18739205

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004005.05925952
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.64220506
3Asthma_Homo sapiens_hsa053103.51140835
4Ribosome_Homo sapiens_hsa030103.36605748
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.29335915
6Histidine metabolism_Homo sapiens_hsa003403.27749827
7ECM-receptor interaction_Homo sapiens_hsa045122.90400112
8Allograft rejection_Homo sapiens_hsa053302.84092507
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.83907850
10Base excision repair_Homo sapiens_hsa034102.67761919
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.43642264
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.35070315
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.33628689
14Type I diabetes mellitus_Homo sapiens_hsa049402.27903009
15Autoimmune thyroid disease_Homo sapiens_hsa053202.26130038
16Linoleic acid metabolism_Homo sapiens_hsa005912.25191685
17Graft-versus-host disease_Homo sapiens_hsa053322.24322872
18Protein digestion and absorption_Homo sapiens_hsa049742.17611454
19Maturity onset diabetes of the young_Homo sapiens_hsa049502.14104704
20Dilated cardiomyopathy_Homo sapiens_hsa054142.07073936
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.04367416
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97535330
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94137368
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.92582266
25Proteasome_Homo sapiens_hsa030501.83347570
26DNA replication_Homo sapiens_hsa030301.77325500
27Focal adhesion_Homo sapiens_hsa045101.70322715
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70017379
29Phenylalanine metabolism_Homo sapiens_hsa003601.64370273
30Peroxisome_Homo sapiens_hsa041461.51903582
31Arginine biosynthesis_Homo sapiens_hsa002201.48938806
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46505583
33Non-homologous end-joining_Homo sapiens_hsa034501.45443444
34Homologous recombination_Homo sapiens_hsa034401.45007807
35Platelet activation_Homo sapiens_hsa046111.44370014
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.44175453
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.44043461
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43227023
39Pyrimidine metabolism_Homo sapiens_hsa002401.41655493
40Hematopoietic cell lineage_Homo sapiens_hsa046401.38118862
41RNA polymerase_Homo sapiens_hsa030201.36858869
42Fanconi anemia pathway_Homo sapiens_hsa034601.34171430
43Parkinsons disease_Homo sapiens_hsa050121.34158804
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33021605
45One carbon pool by folate_Homo sapiens_hsa006701.27791864
46Fatty acid degradation_Homo sapiens_hsa000711.26876039
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.25885955
48Oxidative phosphorylation_Homo sapiens_hsa001901.24827464
49Purine metabolism_Homo sapiens_hsa002301.24777516
50Rheumatoid arthritis_Homo sapiens_hsa053231.22418822
51Glutathione metabolism_Homo sapiens_hsa004801.18330172
52Pyruvate metabolism_Homo sapiens_hsa006201.18235491
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17788321
54Propanoate metabolism_Homo sapiens_hsa006401.17432444
55Other glycan degradation_Homo sapiens_hsa005111.16682670
56Glycosaminoglycan degradation_Homo sapiens_hsa005311.16187576
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15998215
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14700564
59Spliceosome_Homo sapiens_hsa030401.13699509
60Fatty acid metabolism_Homo sapiens_hsa012121.12537473
61Arachidonic acid metabolism_Homo sapiens_hsa005901.11571569
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09108093
63RNA degradation_Homo sapiens_hsa030181.06196322
64Fat digestion and absorption_Homo sapiens_hsa049751.04062948
65PPAR signaling pathway_Homo sapiens_hsa033201.02619323
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02469879
67Systemic lupus erythematosus_Homo sapiens_hsa053221.01040359
68Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00299903
69Antigen processing and presentation_Homo sapiens_hsa046121.00138846
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99887491
71Mismatch repair_Homo sapiens_hsa034300.98704745
72Fatty acid biosynthesis_Homo sapiens_hsa000610.97813069
73Herpes simplex infection_Homo sapiens_hsa051680.96319737
74Chemical carcinogenesis_Homo sapiens_hsa052040.95762362
75Adherens junction_Homo sapiens_hsa045200.94422303
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92736842
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89294549
78Pentose phosphate pathway_Homo sapiens_hsa000300.89170959
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87270261
80Amoebiasis_Homo sapiens_hsa051460.87265454
81PI3K-Akt signaling pathway_Homo sapiens_hsa041510.87084544
82ABC transporters_Homo sapiens_hsa020100.86751748
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.85421110
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84244294
85Ether lipid metabolism_Homo sapiens_hsa005650.84242002
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80694278
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80682917
88Glucagon signaling pathway_Homo sapiens_hsa049220.75444478
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75248505
90Cardiac muscle contraction_Homo sapiens_hsa042600.73484380
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71573071
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.70753864
93Olfactory transduction_Homo sapiens_hsa047400.70439114
94Sulfur metabolism_Homo sapiens_hsa009200.68934820
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68647888
96Proteoglycans in cancer_Homo sapiens_hsa052050.68587256
97Nucleotide excision repair_Homo sapiens_hsa034200.65539804
98Fatty acid elongation_Homo sapiens_hsa000620.63982940
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.62851493
100Basal cell carcinoma_Homo sapiens_hsa052170.62402563
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.62316843
102Melanoma_Homo sapiens_hsa052180.61278975
103Metabolic pathways_Homo sapiens_hsa011000.60836893
104Insulin resistance_Homo sapiens_hsa049310.60735225
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58997425
106Tryptophan metabolism_Homo sapiens_hsa003800.58742069
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58493472
108Thyroid hormone synthesis_Homo sapiens_hsa049180.56891019
109Alzheimers disease_Homo sapiens_hsa050100.56176788
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55504825
111RNA transport_Homo sapiens_hsa030130.55207437
112Selenocompound metabolism_Homo sapiens_hsa004500.54531095
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.54106010
114Sulfur relay system_Homo sapiens_hsa041220.53925250
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53785879
116Tuberculosis_Homo sapiens_hsa051520.53772324
117Hedgehog signaling pathway_Homo sapiens_hsa043400.53238800
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53022004
119Phagosome_Homo sapiens_hsa041450.52622451
120Arginine and proline metabolism_Homo sapiens_hsa003300.52405736
121Butanoate metabolism_Homo sapiens_hsa006500.52151362
122Osteoclast differentiation_Homo sapiens_hsa043800.51634778
123Legionellosis_Homo sapiens_hsa051340.51232152
124Huntingtons disease_Homo sapiens_hsa050160.50892824
125Chemokine signaling pathway_Homo sapiens_hsa040620.48909144
126Nitrogen metabolism_Homo sapiens_hsa009100.48558679
127N-Glycan biosynthesis_Homo sapiens_hsa005100.48042014
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.48040469
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47406199
130Amphetamine addiction_Homo sapiens_hsa050310.47221588
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47155856
132Tight junction_Homo sapiens_hsa045300.46735801
133Vibrio cholerae infection_Homo sapiens_hsa051100.46534010
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.46457228
135African trypanosomiasis_Homo sapiens_hsa051430.45324118
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45271527
137Staphylococcus aureus infection_Homo sapiens_hsa051500.44583586
138Starch and sucrose metabolism_Homo sapiens_hsa005000.44158704
139Ras signaling pathway_Homo sapiens_hsa040140.43916533
140Tyrosine metabolism_Homo sapiens_hsa003500.42743946
141Ovarian steroidogenesis_Homo sapiens_hsa049130.42609068
142Leishmaniasis_Homo sapiens_hsa051400.42283211
143Retinol metabolism_Homo sapiens_hsa008300.42250271
144Rap1 signaling pathway_Homo sapiens_hsa040150.41939578
145Lysosome_Homo sapiens_hsa041420.41754484
146Influenza A_Homo sapiens_hsa051640.40640904
147Biosynthesis of amino acids_Homo sapiens_hsa012300.40489365
148Small cell lung cancer_Homo sapiens_hsa052220.40216521
149Pertussis_Homo sapiens_hsa051330.39798192
150Complement and coagulation cascades_Homo sapiens_hsa046100.38817595
151Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38502421
152Glycerolipid metabolism_Homo sapiens_hsa005610.38460357
153Hippo signaling pathway_Homo sapiens_hsa043900.38369925
154Carbon metabolism_Homo sapiens_hsa012000.38196127
155Calcium signaling pathway_Homo sapiens_hsa040200.38004723
156Renin secretion_Homo sapiens_hsa049240.37531963
157B cell receptor signaling pathway_Homo sapiens_hsa046620.36383928
158Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36129005
159cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34815769
160Viral myocarditis_Homo sapiens_hsa054160.33121955
161Vitamin digestion and absorption_Homo sapiens_hsa049770.32910274
162Toxoplasmosis_Homo sapiens_hsa051450.31981468
163Pancreatic secretion_Homo sapiens_hsa049720.31324102
164Salivary secretion_Homo sapiens_hsa049700.30855437
165Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29266405
166AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27806867
167Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27416723
168Primary immunodeficiency_Homo sapiens_hsa053400.27009237
169Circadian entrainment_Homo sapiens_hsa047130.26706072
170Inositol phosphate metabolism_Homo sapiens_hsa005620.26420060
171Phototransduction_Homo sapiens_hsa047440.26026830
172Pathways in cancer_Homo sapiens_hsa052000.25927239
173Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25823443

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