CYTH4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.14480919
2positive regulation by symbiont of host defense response (GO:0052509)5.85263109
3modulation by symbiont of host defense response (GO:0052031)5.85263109
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.85263109
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.85263109
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.85263109
7modulation by symbiont of host immune response (GO:0052553)5.85263109
8regulation of interferon-beta biosynthetic process (GO:0045357)5.65876604
9regulation of B cell receptor signaling pathway (GO:0050855)5.51329586
10positive regulation of gamma-delta T cell activation (GO:0046645)5.43816947
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.98696603
12negative regulation of cell killing (GO:0031342)4.98696603
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.76428943
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.76428943
15antigen processing and presentation of endogenous antigen (GO:0019883)4.71954569
16macrophage activation involved in immune response (GO:0002281)4.68951093
17detection of other organism (GO:0098543)4.64591434
18regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.46815282
19detection of bacterium (GO:0016045)4.46274440
20positive regulation of B cell differentiation (GO:0045579)4.40778424
21immunoglobulin mediated immune response (GO:0016064)4.33041376
22positive regulation of interferon-alpha production (GO:0032727)4.32699360
23neutrophil activation involved in immune response (GO:0002283)4.26894768
24microglial cell activation (GO:0001774)4.25068558
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.11521596
26regulation of interferon-alpha production (GO:0032647)4.11075156
27detection of external biotic stimulus (GO:0098581)4.03662152
28negative regulation of lymphocyte mediated immunity (GO:0002707)4.00011852
29regulation of B cell differentiation (GO:0045577)3.99111312
30respiratory burst (GO:0045730)3.96160246
31positive regulation of antigen processing and presentation (GO:0002579)3.95861288
32detection of molecule of bacterial origin (GO:0032490)3.93385569
33regulation of gamma-delta T cell differentiation (GO:0045586)3.90716760
34B cell receptor signaling pathway (GO:0050853)3.89120837
35leukocyte aggregation (GO:0070486)3.87482831
36cellular extravasation (GO:0045123)3.82646984
37response to peptidoglycan (GO:0032494)3.81720120
38positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.78224871
39myeloid cell activation involved in immune response (GO:0002275)3.76258282
40response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.76050397
41response to host immune response (GO:0052572)3.76050397
42regulation of gamma-delta T cell activation (GO:0046643)3.74712011
43negative regulation of leukocyte mediated immunity (GO:0002704)3.66331344
44negative regulation of T cell mediated immunity (GO:0002710)3.63790512
45positive thymic T cell selection (GO:0045059)3.62639954
46positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.57643376
47response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.56725951
48response to host (GO:0075136)3.56725951
49response to host defenses (GO:0052200)3.56725951
50detection of biotic stimulus (GO:0009595)3.54612215
51negative regulation of granulocyte differentiation (GO:0030853)3.50822935
52tolerance induction (GO:0002507)3.50098465
53pinocytosis (GO:0006907)3.49349134
54cellular response to interleukin-15 (GO:0071350)3.46055579
55response to muramyl dipeptide (GO:0032495)3.44079152
56regulation of myeloid leukocyte mediated immunity (GO:0002886)3.40092881
57negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.39732286
58negative thymic T cell selection (GO:0045060)3.39343464
59T cell migration (GO:0072678)3.39318278
60macrophage activation (GO:0042116)3.39162160
61regulation of dendritic cell antigen processing and presentation (GO:0002604)3.37185167
62Arp2/3 complex-mediated actin nucleation (GO:0034314)3.34758097
63neutrophil activation (GO:0042119)3.33106302
64regulation of antigen processing and presentation (GO:0002577)3.31076312
65regulation of interleukin-12 biosynthetic process (GO:0045075)3.30293550
66negative T cell selection (GO:0043383)3.29249680
67negative regulation of interleukin-12 production (GO:0032695)3.28460283
68regulation of leukocyte degranulation (GO:0043300)3.25195031
69B cell mediated immunity (GO:0019724)3.23424084
70leukocyte migration involved in inflammatory response (GO:0002523)3.21830588
71regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.20758640
72regulation of tolerance induction (GO:0002643)3.19544564
73granulocyte activation (GO:0036230)3.18837710
74positive regulation of interferon-beta production (GO:0032728)3.18404584
75negative regulation of phagocytosis (GO:0050765)3.14528304
76mast cell activation (GO:0045576)3.13530820
77leukocyte cell-cell adhesion (GO:0007159)3.10589577
78interferon-gamma-mediated signaling pathway (GO:0060333)3.10035468
79myeloid dendritic cell activation (GO:0001773)3.09120432
80regulation of T cell mediated cytotoxicity (GO:0001914)3.07801272
81negative regulation of erythrocyte differentiation (GO:0045647)3.06876510
82interferon-gamma production (GO:0032609)3.05836140
83leukocyte degranulation (GO:0043299)3.05516948
84negative regulation of interleukin-6 production (GO:0032715)3.04954178
85regulation of T-helper 2 cell differentiation (GO:0045628)3.04461674
86positive regulation of mast cell activation involved in immune response (GO:0033008)3.04175717
87positive regulation of mast cell degranulation (GO:0043306)3.04175717
88positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.03896843
89negative regulation of cytokine production involved in immune response (GO:0002719)3.02997324
90positive regulation of mast cell activation (GO:0033005)3.02717349
91negative regulation of T-helper cell differentiation (GO:0045623)3.02111418
92negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.02111418
93positive regulation of chemokine secretion (GO:0090197)3.02105273
94negative regulation of innate immune response (GO:0045824)3.02040794
95mannose metabolic process (GO:0006013)3.00463407
96regulation of mast cell degranulation (GO:0043304)3.00208162
97mature B cell differentiation (GO:0002335)2.99052777
98regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.98617843
99regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.98433004
100regulation of natural killer cell mediated immunity (GO:0002715)2.98433004
101regulation of mast cell activation (GO:0033003)2.98348183
102neutrophil mediated immunity (GO:0002446)2.97342445
103negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.95742568
104defense response to protozoan (GO:0042832)2.95698772
105myeloid leukocyte activation (GO:0002274)2.95189589
106regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.95178021
107I-kappaB phosphorylation (GO:0007252)2.93544488
108germinal center formation (GO:0002467)2.93395649
109response to type I interferon (GO:0034340)2.92930662
110T cell selection (GO:0045058)2.92237006
111antigen processing and presentation via MHC class Ib (GO:0002475)2.91789590
112cellular response to type I interferon (GO:0071357)2.91777261
113type I interferon signaling pathway (GO:0060337)2.91777261
114regulation of T cell tolerance induction (GO:0002664)2.91501963
115negative regulation of type 2 immune response (GO:0002829)2.90018535
116positive regulation of T cell mediated cytotoxicity (GO:0001916)2.87582624
117production of molecular mediator involved in inflammatory response (GO:0002532)2.82757280
118regulation of mast cell activation involved in immune response (GO:0033006)2.81635828
119regulation of interleukin-8 biosynthetic process (GO:0045414)2.81104788
120response to protozoan (GO:0001562)2.80763688
121lipopolysaccharide-mediated signaling pathway (GO:0031663)2.80141285
122thymic T cell selection (GO:0045061)2.79905691
123myeloid dendritic cell differentiation (GO:0043011)2.79065984
124B cell homeostasis (GO:0001782)2.78131041
125response to interleukin-15 (GO:0070672)2.76364684
126JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.75321274
127positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.74644361
128positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.72758091
129positive T cell selection (GO:0043368)2.71627691
130negative regulation of interleukin-17 production (GO:0032700)2.70810346
131negative regulation of B cell proliferation (GO:0030889)2.70409445
132cellular defense response (GO:0006968)2.69949560
133activated T cell proliferation (GO:0050798)2.69604638

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.37595320
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.25985167
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.54944260
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.12542838
5* IRF8_27001747_Chip-Seq_BMDM_Mouse4.01481444
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.96965057
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.85443336
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.84743878
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.46672014
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.38495131
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.11292359
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.02403837
13MYB_21317192_ChIP-Seq_ERMYB_Mouse3.00559827
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.85195981
15SCL_19346495_ChIP-Seq_HPC-7_Human2.83552057
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.72715579
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.63623025
18* VDR_21846776_ChIP-Seq_THP-1_Human2.58062946
19* SPI1_23547873_ChIP-Seq_NB4_Human2.56926286
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.48548726
21MYC_22102868_ChIP-Seq_BL_Human2.46651505
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.46116876
23* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42739844
24* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.42182480
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.41338959
26* RUNX_20019798_ChIP-Seq_JUKART_Human2.40107347
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.31999614
28MYB_26560356_Chip-Seq_TH2_Human2.31722230
29MAF_26560356_Chip-Seq_TH1_Human2.27156221
30* SPI1_23127762_ChIP-Seq_K562_Human2.24697385
31* VDR_24763502_ChIP-Seq_THP-1_Human2.23402486
32* RUNX1_22412390_ChIP-Seq_EML_Mouse2.19302025
33* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.15458509
34MYB_26560356_Chip-Seq_TH1_Human2.03348912
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.00749062
36E2F7_22180533_ChIP-Seq_HELA_Human1.98132856
37UTX_26944678_Chip-Seq_JUKART_Human1.94177974
38* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.91693602
39TCF7_22412390_ChIP-Seq_EML_Mouse1.88017525
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.86307756
41* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76404725
42* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.73139886
43PU_27001747_Chip-Seq_BMDM_Mouse1.72610652
44* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.68285819
45CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.58406308
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.55538146
47* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54137652
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53907897
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51846143
50* GATA3_27048872_Chip-Seq_THYMUS_Human1.49510682
51* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44672656
52CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43358993
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41746262
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41465331
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.40744344
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37788400
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36641864
58* MAF_26560356_Chip-Seq_TH2_Human1.36362078
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.35919284
60KDM2B_26808549_Chip-Seq_DND41_Human1.33146335
61GATA1_22025678_ChIP-Seq_K562_Human1.32772749
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32110441
63* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29097896
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28809447
65* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27676651
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25587980
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24692778
68CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21540496
69* VDR_24787735_ChIP-Seq_THP-1_Human1.21468619
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.20369812
71* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19861967
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19239412
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18888846
74GATA3_26560356_Chip-Seq_TH2_Human1.18166118
75* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17689473
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17209360
77* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12923272
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.10147307
79* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09213290
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06961619
81FOXM1_23109430_ChIP-Seq_U2OS_Human1.05541484
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05416790
83BCOR_27268052_Chip-Seq_Bcells_Human1.02348673
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01894841
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.01623748
86* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00706098
87STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99787064
88TFEB_21752829_ChIP-Seq_HELA_Human0.94739636
89ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94686855
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93677652
91LXR_22292898_ChIP-Seq_THP-1_Human0.93522209
92GATA2_19941826_ChIP-Seq_K562_Human0.91820946
93GATA1_19941826_ChIP-Seq_K562_Human0.91329112
94* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89433383
95SPI1_20517297_ChIP-Seq_HL60_Human0.88645673
96* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85482447
97HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85026338
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83731841
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.82219143
100CTCF_27219007_Chip-Seq_ERYTHROID_Human0.78569374
101CIITA_25753668_ChIP-Seq_RAJI_Human0.77544079
102NCOR1_26117541_ChIP-Seq_K562_Human0.76415687
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73967163
104* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72184842
105BCL6_27268052_Chip-Seq_Bcells_Human0.70461310
106* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69851739
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69654522
108KDM2B_26808549_Chip-Seq_JURKAT_Human0.69601656
109RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.69208250

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.23429640
2MP0005058_abnormal_lysosome_morphology3.41469846
3MP0003303_peritoneal_inflammation3.28255091
4MP0003436_decreased_susceptibility_to3.21220542
5MP0006082_CNS_inflammation3.20075026
6MP0005671_abnormal_response_to3.19538290
7MP0002419_abnormal_innate_immunity2.98784008
8MP0005000_abnormal_immune_tolerance2.91804996
9MP0001800_abnormal_humoral_immune2.86407705
10MP0000685_abnormal_immune_system2.82224964
11MP0002452_abnormal_antigen_presenting2.77994849
12MP0001790_abnormal_immune_system2.75469532
13MP0005387_immune_system_phenotype2.75469532
14MP0005025_abnormal_response_to2.69074971
15MP0003172_abnormal_lysosome_physiology2.66473929
16MP0009785_altered_susceptibility_to2.66386451
17MP0005464_abnormal_platelet_physiology2.61391066
18MP0002723_abnormal_immune_serum2.59944415
19MP0002420_abnormal_adaptive_immunity2.50982693
20MP0001819_abnormal_immune_cell2.50227517
21MP0002148_abnormal_hypersensitivity_rea2.48342520
22MP0003191_abnormal_cellular_cholesterol2.34160071
23MP0003724_increased_susceptibility_to2.22046706
24MP0003300_gastrointestinal_ulcer2.14053569
25MP0002405_respiratory_system_inflammati2.09097851
26MP0002398_abnormal_bone_marrow2.05724039
27MP0004510_myositis1.99842795
28MP0000716_abnormal_immune_system1.99192452
29MP0009333_abnormal_splenocyte_physiolog1.92904644
30MP0003763_abnormal_thymus_physiology1.92813628
31MP0000689_abnormal_spleen_morphology1.90522790
32MP0002396_abnormal_hematopoietic_system1.89666385
33MP0002166_altered_tumor_susceptibility1.85633363
34MP0001533_abnormal_skeleton_physiology1.83284333
35MP0001845_abnormal_inflammatory_respons1.81988282
36MP0009840_abnormal_foam_cell1.80952646
37MP0003183_abnormal_peptide_metabolism1.76730009
38MP0002722_abnormal_immune_system1.73922283
39MP0004947_skin_inflammation1.73404729
40MP0000465_gastrointestinal_hemorrhage1.72029147
41MP0000569_abnormal_digit_pigmentation1.65999645
42MP0001853_heart_inflammation1.65967335
43MP0002429_abnormal_blood_cell1.65207868
44MP0010155_abnormal_intestine_physiology1.64041291
45MP0009278_abnormal_bone_marrow1.60085041
46MP0008260_abnormal_autophagy1.58759696
47MP0008469_abnormal_protein_level1.55361645
48MP0001873_stomach_inflammation1.55104053
49MP0005174_abnormal_tail_pigmentation1.51514546
50MP0000343_altered_response_to1.49261220
51MP0002006_tumorigenesis1.48558435
52MP0005451_abnormal_body_composition1.47951560
53MP0003448_altered_tumor_morphology1.45172883
54MP0005310_abnormal_salivary_gland1.42729595
55MP0005397_hematopoietic_system_phenotyp1.41350541
56MP0001545_abnormal_hematopoietic_system1.41350541
57MP0004808_abnormal_hematopoietic_stem1.40471307
58MP0003075_altered_response_to1.36809156
59MP0002933_joint_inflammation1.36569205
60MP0001851_eye_inflammation1.31936806
61MP0000858_altered_metastatic_potential1.27861115
62MP0002132_abnormal_respiratory_system1.26471373
63MP0003690_abnormal_glial_cell1.25927785
64MP0000703_abnormal_thymus_morphology1.25580832
65MP0000604_amyloidosis1.20711151
66MP0002998_abnormal_bone_remodeling1.20597641
67MP0010307_abnormal_tumor_latency1.20513600
68MP0002277_abnormal_respiratory_mucosa1.19674064
69MP0000015_abnormal_ear_pigmentation1.11682674
70MP0003866_abnormal_defecation1.11260644
71MP0005166_decreased_susceptibility_to1.09471275
72MP0000490_abnormal_crypts_of1.04675704
73MP0004381_abnormal_hair_follicle1.03752901
74MP0003566_abnormal_cell_adhesion1.01248651
75MP0009764_decreased_sensitivity_to0.97747207
76MP0008004_abnormal_stomach_pH0.94517623
77MP0003806_abnormal_nucleotide_metabolis0.92228028
78MP0003828_pulmonary_edema0.90161411
79MP0009763_increased_sensitivity_to0.87459374
80MP0003045_fibrosis0.86924904
81MP0002138_abnormal_hepatobiliary_system0.82725494
82MP0005076_abnormal_cell_differentiation0.82612390
83MP0000249_abnormal_blood_vessel0.81155747
84MP0005390_skeleton_phenotype0.77537571
85MP0005023_abnormal_wound_healing0.77221164
86MP0000371_diluted_coat_color0.76602090
87MP0003656_abnormal_erythrocyte_physiolo0.73359727
88MP0005075_abnormal_melanosome_morpholog0.73133372
89MP0009765_abnormal_xenobiotic_induced0.67659785
90MP0003795_abnormal_bone_structure0.67249190
91MP0001986_abnormal_taste_sensitivity0.65333117
92MP0005167_abnormal_blood-brain_barrier0.65067944
93MP0002019_abnormal_tumor_incidence0.64922054
94MP0008874_decreased_physiological_sensi0.62324629
95MP0006054_spinal_hemorrhage0.62144829
96MP0002928_abnormal_bile_duct0.62119492
97MP0002332_abnormal_exercise_endurance0.61785014
98MP0008873_increased_physiological_sensi0.61210718
99MP0002136_abnormal_kidney_physiology0.60697567
100MP0000609_abnormal_liver_physiology0.59963592
101MP0001915_intracranial_hemorrhage0.57518790
102MP0001663_abnormal_digestive_system0.57452396
103MP0000767_abnormal_smooth_muscle0.56816520
104MP0000920_abnormal_myelination0.56789493
105MP0002254_reproductive_system_inflammat0.55997098
106MP0005319_abnormal_enzyme/_coenzyme0.55186014
107MP0003091_abnormal_cell_migration0.54756862
108MP0003279_aneurysm0.51882376
109MP0000598_abnormal_liver_morphology0.51485707
110MP0002095_abnormal_skin_pigmentation0.51345061
111MP0002693_abnormal_pancreas_physiology0.51303999
112MP0004130_abnormal_muscle_cell0.51278343
113MP0004883_abnormal_blood_vessel0.51010102
114MP0003329_amyloid_beta_deposits0.49628785
115MP0003453_abnormal_keratinocyte_physiol0.47777315
116MP0005164_abnormal_response_to0.47200972
117MP0001958_emphysema0.46841015
118MP0005381_digestive/alimentary_phenotyp0.46190834
119MP0010352_gastrointestinal_tract_polyps0.46089924

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.51592091
2Eczematoid dermatitis (HP:0000976)5.78023393
3Recurrent bacterial skin infections (HP:0005406)5.68465772
4Systemic lupus erythematosus (HP:0002725)5.44964055
5Increased cerebral lipofuscin (HP:0011813)4.55446646
6Recurrent gram-negative bacterial infections (HP:0005420)4.52918841
7Vacuolated lymphocytes (HP:0001922)4.29548836
8Myositis (HP:0100614)4.21855280
9Abnormality of glycolipid metabolism (HP:0010969)4.17376261
10Abnormality of liposaccharide metabolism (HP:0010968)4.17376261
11Abnormality of glycosphingolipid metabolism (HP:0004343)4.17376261
12Abnormality of macrophages (HP:0004311)4.02895602
13Elevated erythrocyte sedimentation rate (HP:0003565)3.96779236
14Glomerulonephritis (HP:0000099)3.95911987
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.94342810
16Recurrent fungal infections (HP:0002841)3.89391762
17Dysostosis multiplex (HP:0000943)3.88427365
18Recurrent skin infections (HP:0001581)3.81794673
19Gastrointestinal infarctions (HP:0005244)3.71791565
20Encephalitis (HP:0002383)3.64873147
21Mediastinal lymphadenopathy (HP:0100721)3.61515368
22Recurrent viral infections (HP:0004429)3.55515365
23Keratoconjunctivitis (HP:0001096)3.45530953
24IgM deficiency (HP:0002850)3.41481146
25Chronic obstructive pulmonary disease (HP:0006510)3.37634272
26Obstructive lung disease (HP:0006536)3.37634272
27Orchitis (HP:0100796)3.29912270
28Chronic otitis media (HP:0000389)3.28071873
29Gingivitis (HP:0000230)3.16893943
30Disinhibition (HP:0000734)3.13276872
31Colitis (HP:0002583)3.13056193
32Cellulitis (HP:0100658)3.11810613
33Inflammation of the large intestine (HP:0002037)3.10292432
34Stomatitis (HP:0010280)3.08938696
35Chronic mucocutaneous candidiasis (HP:0002728)3.08296472
36Recurrent cutaneous fungal infections (HP:0011370)3.08296472
37Retrobulbar optic neuritis (HP:0100654)3.04444252
38Optic neuritis (HP:0100653)3.04444252
39Mucopolysacchariduria (HP:0008155)3.00054568
40Urinary glycosaminoglycan excretion (HP:0003541)3.00054568
41Meningitis (HP:0001287)2.99463192
42Pustule (HP:0200039)2.98669859
43Gastrointestinal inflammation (HP:0004386)2.98059926
44Autoimmune thrombocytopenia (HP:0001973)2.95525716
45Hematochezia (HP:0002573)2.94464044
46Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.92469139
47Spontaneous hematomas (HP:0007420)2.89714435
48Abnormality of mucopolysaccharide metabolism (HP:0011020)2.86988821
49Abnormality of polysaccharide metabolism (HP:0011012)2.86988821
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.86988821
51Agnosia (HP:0010524)2.83023568
52Vasculitis (HP:0002633)2.82178143
53Periodontitis (HP:0000704)2.75087088
54Complement deficiency (HP:0004431)2.67619327
55Interstitial pulmonary disease (HP:0006530)2.64963195
56Amyloidosis (HP:0011034)2.63300129
57Episodic fever (HP:0001954)2.63243814
58Nasal polyposis (HP:0100582)2.59986157
59Pulmonary embolism (HP:0002204)2.58865131
60Anorexia (HP:0002039)2.57265398
61Arterial thrombosis (HP:0004420)2.56948014
62Leukocytosis (HP:0001974)2.56053880
63Loss of speech (HP:0002371)2.55565456
64Recurrent bronchitis (HP:0002837)2.54649113
65Axonal loss (HP:0003447)2.53920762
66Hypochromic microcytic anemia (HP:0004840)2.53505282
67Thrombocytosis (HP:0001894)2.52745619
68Abnormality of complement system (HP:0005339)2.49592660
69Abnormality of the nasal mucosa (HP:0000433)2.48425989
70Petechiae (HP:0000967)2.48091238
71Abnormal delayed hypersensitivity skin test (HP:0002963)2.47297695
72Increased IgM level (HP:0003496)2.47111687
73Hypochromic anemia (HP:0001931)2.46884625
74Osteomyelitis (HP:0002754)2.46152233
75Thoracic kyphosis (HP:0002942)2.44155764
76Prolonged bleeding time (HP:0003010)2.42949969
77Hepatosplenomegaly (HP:0001433)2.42345882
78Abnormal platelet function (HP:0011869)2.41787876
79Impaired platelet aggregation (HP:0003540)2.41787876
80Pulmonary infiltrates (HP:0002113)2.40741881
81Panhypogammaglobulinemia (HP:0003139)2.36616331
82Gangrene (HP:0100758)2.36347663
83T lymphocytopenia (HP:0005403)2.35876588
84Myocardial infarction (HP:0001658)2.35377309
85Chronic diarrhea (HP:0002028)2.34635202
86Nephritis (HP:0000123)2.34367459
87Abnormality of the pleura (HP:0002103)2.32125684
88Epistaxis (HP:0000421)2.28993413
89Abnormality of T cell number (HP:0011839)2.28395862
90Purpura (HP:0000979)2.25510730
91Eosinophilia (HP:0001880)2.25358025
92Sepsis (HP:0100806)2.24829513
93Increased serum ferritin (HP:0003281)2.24702855
94Basal ganglia calcification (HP:0002135)2.24083552
95Abnormality of T cells (HP:0002843)2.22799343
96Agammaglobulinemia (HP:0004432)2.21747969
97Hemoptysis (HP:0002105)2.21635150
98Hypergammaglobulinemia (HP:0010702)2.16498580
99Urticaria (HP:0001025)2.15591434
100Peritonitis (HP:0002586)2.14604143
101Lymphopenia (HP:0001888)2.14391066
102Spondylolisthesis (HP:0003302)2.13598993
103Polyneuropathy (HP:0001271)2.10231291
104Cerebral aneurysm (HP:0004944)2.10030253
105Gingival bleeding (HP:0000225)2.09605484
106Glomerulopathy (HP:0100820)2.09139298
107Increased IgE level (HP:0003212)2.06072414
108Abnormality of iron homeostasis (HP:0011031)2.06043285
109Abnormality of cells of the lymphoid lineage (HP:0012140)2.04916576
110Vertigo (HP:0002321)2.04273745
111Abnormality of the endocardium (HP:0004306)2.03865289
112Thyroiditis (HP:0100646)2.03381669
113Premature loss of primary teeth (HP:0006323)2.02293941
114Abnormality of T cell physiology (HP:0011840)2.02248279
115Abnormality of eosinophils (HP:0001879)2.00391612
116Acne (HP:0001061)1.99320212
117Chest pain (HP:0100749)1.99166568
118Keratoconjunctivitis sicca (HP:0001097)1.98860945
119Recurrent pneumonia (HP:0006532)1.98728495
120J-shaped sella turcica (HP:0002680)1.98473004
121Abnormality of the lumbar spine (HP:0100712)1.98053759
122Gastrointestinal stroma tumor (HP:0100723)1.97717904
123Granulocytopenia (HP:0001913)1.96250577
124Keratitis (HP:0000491)1.96034765
125Abnormality of the thoracic spine (HP:0100711)1.95630688
126Microcytic anemia (HP:0001935)1.94820224
127Autoimmune hemolytic anemia (HP:0001890)1.93052701
128Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.92793785
129Abnormality of the peritoneum (HP:0002585)1.91392288

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.47221268
2TGFBR23.45535186
3BLK3.11677489
4TYK23.09123362
5KIT2.83903063
6IRAK42.82000039
7CSF1R2.64307134
8TXK2.62815697
9ZAP702.51333162
10RIPK42.48662221
11TBK12.45995778
12STK102.26530878
13MAP3K142.08792759
14JAK32.06423490
15PRPF4B2.04056190
16FES1.97957960
17JAK11.97915540
18ERN11.97288932
19BTK1.95034321
20IRAK31.86804481
21ITK1.83899513
22IKBKE1.82706397
23SYK1.77587249
24HCK1.75030743
25CSK1.71466672
26TAOK11.71108167
27TEC1.63485876
28LCK1.57761879
29TAOK31.48030609
30IKBKB1.47990084
31MAP3K131.44941986
32MAP2K31.42617957
33SIK21.41027135
34EPHB11.38958365
35TRIB31.38309696
36CLK11.37558125
37PKN21.36965333
38CAMK1D1.36226771
39GRK61.31363324
40LYN1.28228588
41EEF2K1.21038375
42GRK71.19453261
43MAP3K11.16688845
44FGFR41.07620726
45BMPR21.07389101
46JAK21.06686630
47PAK41.04033359
48LRRK21.03157208
49MARK31.02588314
50NEK91.00007572
51CAMK1G0.99498602
52TAOK20.99045063
53KSR20.97964709
54NME20.97796049
55RPS6KA40.96074090
56FGR0.92092113
57MARK20.90458696
58MATK0.90097718
59TTN0.88984130
60PIM10.88525567
61FGFR30.87939349
62MAP3K100.87594297
63IRAK10.87243154
64CDC42BPA0.79610234
65YES10.79523312
66PRKD20.78066874
67PTK60.77607778
68CHUK0.71929617
69IRAK20.70060651
70TRPM70.69130119
71RIPK10.65805161
72FLT30.63478463
73PIK3CG0.63173225
74CDK60.61957793
75CAMKK20.59718893
76SCYL20.59242239
77TESK20.58808543
78HIPK20.55348513
79PDK10.54679994
80MAP3K50.53893196
81EGFR0.53860922
82MAPK150.53807181
83MAP3K60.52496770
84KDR0.51196131
85MAP2K60.51110277
86STK40.51017151
87PRKCQ0.50396871
88PRKCH0.48919422
89DYRK1B0.48817846
90ABL10.48762220
91PIM20.48675224
92EPHA30.46680144
93MAPKAPK20.45647259
94MAP3K70.45571649
95MAPK120.45557693
96STK110.43973618
97RPS6KA60.43649532
98PTK2B0.43144546
99MAPK40.42125069
100CDK40.41105743
101TNK20.40755865
102FYN0.40718601
103PRKCD0.40598262
104IGF1R0.40137856
105CDK120.39834296
106CDK190.39554567
107RAF10.39102089
108MAP3K80.37321215
109SGK30.37285197
110NLK0.35913662
111MOS0.35268473
112NEK20.34978631
113RPS6KL10.34349508
114RPS6KC10.34349508
115MAP3K20.34168365
116MAP3K30.34044268
117DAPK20.32277214
118MAP3K110.31659648
119CAMKK10.31236730
120SIK30.30715101
121MAPK110.29775006
122MAP2K20.29676451
123ADRBK20.29137377
124SIK10.28901257
125ACVR1B0.28374270
126KSR10.27303473
127ALK0.26016964
128PDPK10.24793653
129PDGFRB0.24468071
130MAPK70.24193643
131CDK90.24087288

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.54190464
2Leishmaniasis_Homo sapiens_hsa051403.14224956
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.88460274
4Other glycan degradation_Homo sapiens_hsa005112.87909571
5Osteoclast differentiation_Homo sapiens_hsa043802.79547091
6B cell receptor signaling pathway_Homo sapiens_hsa046622.60012609
7Lysosome_Homo sapiens_hsa041422.39712185
8Antigen processing and presentation_Homo sapiens_hsa046122.38881938
9Primary immunodeficiency_Homo sapiens_hsa053402.36678047
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.19814243
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.15891794
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.14291910
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.14247295
14Pertussis_Homo sapiens_hsa051332.11824483
15Measles_Homo sapiens_hsa051622.10660804
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.00822077
17Tuberculosis_Homo sapiens_hsa051521.95464019
18Hematopoietic cell lineage_Homo sapiens_hsa046401.81058685
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.76993244
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.74979017
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.74645032
22Legionellosis_Homo sapiens_hsa051341.73178828
23T cell receptor signaling pathway_Homo sapiens_hsa046601.62592419
24Malaria_Homo sapiens_hsa051441.62332966
25Graft-versus-host disease_Homo sapiens_hsa053321.60184099
26Toxoplasmosis_Homo sapiens_hsa051451.59975296
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53512234
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50265855
29Chemokine signaling pathway_Homo sapiens_hsa040621.45970811
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45236155
31Influenza A_Homo sapiens_hsa051641.44284610
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.39130920
33Shigellosis_Homo sapiens_hsa051311.37221846
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.37166899
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35078408
36Herpes simplex infection_Homo sapiens_hsa051681.31268309
37Apoptosis_Homo sapiens_hsa042101.30857588
38Salmonella infection_Homo sapiens_hsa051321.29073320
39Phagosome_Homo sapiens_hsa041451.27812615
40Allograft rejection_Homo sapiens_hsa053301.27179329
41Hepatitis B_Homo sapiens_hsa051611.18194245
42Viral myocarditis_Homo sapiens_hsa054161.17378246
43Rheumatoid arthritis_Homo sapiens_hsa053231.14386094
44TNF signaling pathway_Homo sapiens_hsa046681.14198798
45Platelet activation_Homo sapiens_hsa046111.13088423
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09592187
47Acute myeloid leukemia_Homo sapiens_hsa052211.08070654
48Chronic myeloid leukemia_Homo sapiens_hsa052201.06462303
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04099333
50Pancreatic cancer_Homo sapiens_hsa052121.03876809
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01988218
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98454331
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92996074
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88845427
55Complement and coagulation cascades_Homo sapiens_hsa046100.85721650
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.85439136
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84957270
58Asthma_Homo sapiens_hsa053100.84479253
59Hepatitis C_Homo sapiens_hsa051600.80286648
60Epstein-Barr virus infection_Homo sapiens_hsa051690.72957615
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72358509
62Caffeine metabolism_Homo sapiens_hsa002320.71986484
63* Endocytosis_Homo sapiens_hsa041440.66051162
64Notch signaling pathway_Homo sapiens_hsa043300.63930260
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63432921
66VEGF signaling pathway_Homo sapiens_hsa043700.62562824
67Prion diseases_Homo sapiens_hsa050200.60403552
68African trypanosomiasis_Homo sapiens_hsa051430.59683237
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59673644
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57209424
71Viral carcinogenesis_Homo sapiens_hsa052030.57143722
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55660961
73Autoimmune thyroid disease_Homo sapiens_hsa053200.55252292
74Non-small cell lung cancer_Homo sapiens_hsa052230.55180146
75HTLV-I infection_Homo sapiens_hsa051660.55094775
76Colorectal cancer_Homo sapiens_hsa052100.54476034
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.53831813
78Amoebiasis_Homo sapiens_hsa051460.51735421
79Prolactin signaling pathway_Homo sapiens_hsa049170.49529110
80* Phospholipase D signaling pathway_Homo sapiens_hsa040720.48774262
81Collecting duct acid secretion_Homo sapiens_hsa049660.46100371
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45182314
83HIF-1 signaling pathway_Homo sapiens_hsa040660.45040815
84Dorso-ventral axis formation_Homo sapiens_hsa043200.44027805
85GnRH signaling pathway_Homo sapiens_hsa049120.42404584
86Choline metabolism in cancer_Homo sapiens_hsa052310.40530345
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39250006
88Small cell lung cancer_Homo sapiens_hsa052220.39092826
89Type II diabetes mellitus_Homo sapiens_hsa049300.38386023
90ABC transporters_Homo sapiens_hsa020100.37616973
91Regulation of autophagy_Homo sapiens_hsa041400.36434107
92Type I diabetes mellitus_Homo sapiens_hsa049400.36074466
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.34909598
94Insulin resistance_Homo sapiens_hsa049310.33455654
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32609739
96Endometrial cancer_Homo sapiens_hsa052130.32312681
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.31402882
98Renal cell carcinoma_Homo sapiens_hsa052110.30943461
99Proteoglycans in cancer_Homo sapiens_hsa052050.28802721
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27511994
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27068267
102Inositol phosphate metabolism_Homo sapiens_hsa005620.26980141
103FoxO signaling pathway_Homo sapiens_hsa040680.24536990
104Sphingolipid metabolism_Homo sapiens_hsa006000.24206353
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23929008
106Renin-angiotensin system_Homo sapiens_hsa046140.23184057
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22715449
108Rap1 signaling pathway_Homo sapiens_hsa040150.22426320
109MAPK signaling pathway_Homo sapiens_hsa040100.22292953
110N-Glycan biosynthesis_Homo sapiens_hsa005100.19341119
111mTOR signaling pathway_Homo sapiens_hsa041500.18871599
112Pentose phosphate pathway_Homo sapiens_hsa000300.15313918
113Focal adhesion_Homo sapiens_hsa045100.14964119

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