CYTH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1planar cell polarity pathway involved in neural tube closure (GO:0090179)4.26459898
2cell-cell junction maintenance (GO:0045217)4.20756338
3cell migration in hindbrain (GO:0021535)4.20003399
4axon ensheathment in central nervous system (GO:0032291)3.99703131
5central nervous system myelination (GO:0022010)3.99703131
6regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.89847645
7pyrimidine nucleobase catabolic process (GO:0006208)3.45788001
8negative regulation of microtubule polymerization (GO:0031115)3.42660376
9axonemal dynein complex assembly (GO:0070286)3.39004480
10layer formation in cerebral cortex (GO:0021819)3.37922068
11cell junction maintenance (GO:0034331)3.37609814
12endothelial cell chemotaxis (GO:0035767)3.33803303
13ganglion development (GO:0061548)3.25169406
14nucleosome disassembly (GO:0006337)3.24539518
15protein-DNA complex disassembly (GO:0032986)3.24539518
16calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.24431296
17camera-type eye morphogenesis (GO:0048593)3.21450617
18axonal fasciculation (GO:0007413)3.20555249
19postsynaptic membrane organization (GO:0001941)3.19092269
20axon extension involved in axon guidance (GO:0048846)3.17578561
21neuron projection extension involved in neuron projection guidance (GO:1902284)3.17578561
22regulation of axon extension involved in axon guidance (GO:0048841)3.12147523
23neuron recognition (GO:0008038)3.10314408
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.08221751
25regulation of axon guidance (GO:1902667)3.07610522
26cranial nerve morphogenesis (GO:0021602)3.07311200
27dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.06839352
28convergent extension (GO:0060026)3.05834198
29dendritic spine morphogenesis (GO:0060997)3.03328936
30Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.02409729
31synapse assembly (GO:0007416)3.02328125
32establishment of planar polarity (GO:0001736)3.02203652
33establishment of tissue polarity (GO:0007164)3.02203652
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.00183250
35negative regulation of microtubule polymerization or depolymerization (GO:0031111)2.99532521
36ensheathment of neurons (GO:0007272)2.95531291
37axon ensheathment (GO:0008366)2.95531291
38neuronal stem cell maintenance (GO:0097150)2.95281759
39establishment of mitochondrion localization (GO:0051654)2.94198335
40myelination (GO:0042552)2.90962731
41negative regulation of microtubule depolymerization (GO:0007026)2.90681604
42embryonic body morphogenesis (GO:0010172)2.90206907
43regulation of establishment of planar polarity (GO:0090175)2.85517495
44histone H2B ubiquitination (GO:0033523)2.85429773
45peptidyl-arginine omega-N-methylation (GO:0035247)2.84040247
46negative regulation of inclusion body assembly (GO:0090084)2.84037056
47negative regulation of catenin import into nucleus (GO:0035414)2.80093121
48axon extension (GO:0048675)2.79115077
49polarized epithelial cell differentiation (GO:0030859)2.78292479
50lung-associated mesenchyme development (GO:0060484)2.78223640
51ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.77052991
52positive regulation of gastrulation (GO:2000543)2.76116172
53fusion of sperm to egg plasma membrane (GO:0007342)2.75797233
54regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.74935223
55negative regulation of axon extension involved in axon guidance (GO:0048843)2.74806146
56body morphogenesis (GO:0010171)2.74618048
57negative regulation of axon guidance (GO:1902668)2.74583758
58regulation of microtubule depolymerization (GO:0031114)2.66586334
59positive regulation of synapse maturation (GO:0090129)2.66172874
60forebrain neuron differentiation (GO:0021879)2.65863643
61regulation of NFAT protein import into nucleus (GO:0051532)2.65516017
62negative regulation of axonogenesis (GO:0050771)2.64754472
63ear development (GO:0043583)2.64110906
64lung epithelium development (GO:0060428)2.62909720
65positive regulation of dendrite morphogenesis (GO:0050775)2.62815905
66cerebral cortex radially oriented cell migration (GO:0021799)2.62752226
67cochlea morphogenesis (GO:0090103)2.61727965
68cilium movement (GO:0003341)2.61487236
69cerebral cortex neuron differentiation (GO:0021895)2.60664324
70vocalization behavior (GO:0071625)2.59684861
71dendrite morphogenesis (GO:0048813)2.59517407
72establishment or maintenance of monopolar cell polarity (GO:0061339)2.57458731
73establishment of monopolar cell polarity (GO:0061162)2.57458731
74synaptonemal complex organization (GO:0070193)2.56907865
75limb bud formation (GO:0060174)2.56183769
76positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.54579451
77negative regulation of JAK-STAT cascade (GO:0046426)2.53837266
78protein retention in ER lumen (GO:0006621)2.52329715
79mitochondrion transport along microtubule (GO:0047497)2.51389215
80establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.51389215
81facial nerve structural organization (GO:0021612)2.51332530
82microtubule severing (GO:0051013)2.51128452
83neural tube development (GO:0021915)2.50190963
84dendritic spine organization (GO:0097061)2.49059274
85negative regulation of axon extension (GO:0030517)2.48735697
86dendrite development (GO:0016358)2.48721259
87regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.48161235
88peptidyl-arginine N-methylation (GO:0035246)2.47927011
89peptidyl-arginine methylation (GO:0018216)2.47927011
90synaptonemal complex assembly (GO:0007130)2.47890230
91collecting duct development (GO:0072044)2.47704367
92establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.47348282
93negative regulation of organelle assembly (GO:1902116)2.46320537
94neuronal ion channel clustering (GO:0045161)2.45970543
95head development (GO:0060322)2.45465455
96regulation of inclusion body assembly (GO:0090083)2.44708468
97glial cell proliferation (GO:0014009)2.44244923
98regulation of somitogenesis (GO:0014807)2.44033741
99histone H4 deacetylation (GO:0070933)2.43835021
100embryonic camera-type eye development (GO:0031076)2.43434160
101intracellular estrogen receptor signaling pathway (GO:0030520)2.42776324
102regulation of synapse maturation (GO:0090128)2.41633962
103histone H3 deacetylation (GO:0070932)2.40601775
104synaptic vesicle endocytosis (GO:0048488)2.40537085
105spindle assembly involved in mitosis (GO:0090307)2.40183500
106left/right pattern formation (GO:0060972)2.39112438
107hippocampus development (GO:0021766)2.38736987
108male meiosis (GO:0007140)2.38155397
109negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.37964100
110positive regulation of synapse assembly (GO:0051965)2.37680168
111mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.37338646
112positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.37338646
113cilium or flagellum-dependent cell motility (GO:0001539)2.37313917
114negative regulation of GTPase activity (GO:0034260)2.37171401
115negative regulation of GTP catabolic process (GO:0033125)2.37171401
116neuron projection extension (GO:1990138)2.36975889
117acrosome reaction (GO:0007340)2.36756821
118establishment or maintenance of apical/basal cell polarity (GO:0035088)2.35462418
119establishment or maintenance of bipolar cell polarity (GO:0061245)2.35462418
120positive regulation of axonogenesis (GO:0050772)2.35396259
121regulation of autophagic vacuole assembly (GO:2000785)2.34720856
122positive regulation of protein kinase C signaling (GO:0090037)2.34531981
123presynaptic membrane assembly (GO:0097105)2.33991953
124RNA localization (GO:0006403)2.33946467
125regulation of axonogenesis (GO:0050770)2.33866692
126synaptic vesicle docking involved in exocytosis (GO:0016081)2.33716354
127regulation of ARF GTPase activity (GO:0032312)2.33458602
128positive regulation of oligodendrocyte differentiation (GO:0048714)2.32803129
129neuron cell-cell adhesion (GO:0007158)2.32714723
130piRNA metabolic process (GO:0034587)2.31921419
131behavioral response to nicotine (GO:0035095)2.31911811
132asymmetric protein localization (GO:0008105)2.31725205
133lens morphogenesis in camera-type eye (GO:0002089)2.31069929
134regulation of collateral sprouting (GO:0048670)2.30396745
135semaphorin-plexin signaling pathway (GO:0071526)2.29287233
136regulation of early endosome to late endosome transport (GO:2000641)2.28683206
137regulation of hydrogen peroxide metabolic process (GO:0010310)2.28439226
138centrosome localization (GO:0051642)2.28299561
139astrocyte development (GO:0014002)2.27756383
140coronary vasculature morphogenesis (GO:0060977)2.26648848
141renal system development (GO:0072001)2.26206056
142histone arginine methylation (GO:0034969)2.25930550
143ephrin receptor signaling pathway (GO:0048013)2.25818930
144pattern specification involved in kidney development (GO:0061004)2.25467386
145negative regulation of oligodendrocyte differentiation (GO:0048715)2.25287704
146localization within membrane (GO:0051668)2.24889706
147synaptic vesicle maturation (GO:0016188)2.24661921
148sperm motility (GO:0030317)2.24506877
149regulation of microtubule polymerization or depolymerization (GO:0031110)2.24340217
150spinal cord development (GO:0021510)2.23568400
151nucleobase catabolic process (GO:0046113)2.22368576
152actin filament depolymerization (GO:0030042)2.21986121
153protein insertion into membrane (GO:0051205)2.21063490
154lateral sprouting from an epithelium (GO:0060601)2.20950051
155spliceosomal snRNP assembly (GO:0000387)2.20284292
156positive regulation of actin filament depolymerization (GO:0030836)2.20213153
157cytoskeletal anchoring at plasma membrane (GO:0007016)2.19751121
158maturation of SSU-rRNA (GO:0030490)2.18732200
159protein polyglutamylation (GO:0018095)2.17648012
160microtubule depolymerization (GO:0007019)2.16925904
161viral transcription (GO:0019083)2.15523303
162ventricular system development (GO:0021591)2.15141666
163positive regulation of filopodium assembly (GO:0051491)2.14670441
164blastocyst development (GO:0001824)2.14414936
165regulation of oligodendrocyte differentiation (GO:0048713)2.14225819
166epithelial cilium movement (GO:0003351)2.13725001
167spermatid development (GO:0007286)2.13724092
168mitotic spindle organization (GO:0007052)2.13202390
169central nervous system projection neuron axonogenesis (GO:0021952)2.12903893
170protein complex disassembly (GO:0043241)2.12296463
171protein neddylation (GO:0045116)2.11466989
172spliceosomal complex assembly (GO:0000245)2.11110166
173regulation of microtubule-based movement (GO:0060632)2.11045642
174mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.10399419
175lens fiber cell development (GO:0070307)2.08972796

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human4.14610250
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.91191582
3EZH2_22144423_ChIP-Seq_EOC_Human3.33981893
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.17963103
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.44688571
6DROSHA_22980978_ChIP-Seq_HELA_Human2.37390985
7ZNF263_19887448_ChIP-Seq_K562_Human2.30815306
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.22383847
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16588343
10ZFP281_18757296_ChIP-ChIP_E14_Mouse2.09459074
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.01771431
12TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.96948565
13RARG_19884340_ChIP-ChIP_MEFs_Mouse1.91342520
14EZH2_27304074_Chip-Seq_ESCs_Mouse1.89046185
15ZNF274_21170338_ChIP-Seq_K562_Hela1.82734633
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81900748
17ERG_21242973_ChIP-ChIP_JURKAT_Human1.80358514
18RACK7_27058665_Chip-Seq_MCF-7_Human1.77889180
19SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74049789
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.69631347
21EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.68957965
22P68_20966046_ChIP-Seq_HELA_Human1.63707691
23DNAJC2_21179169_ChIP-ChIP_NT2_Human1.63315261
24KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.62587176
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.62455924
26SMC4_20622854_ChIP-Seq_HELA_Human1.61828232
27GATA1_26923725_Chip-Seq_HPCs_Mouse1.60181833
28CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.57852337
29OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.57640363
30XRN2_22483619_ChIP-Seq_HELA_Human1.56474907
31* KDM2B_26808549_Chip-Seq_K562_Human1.56096261
32ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.55899662
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.55864635
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53367849
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51311687
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.51294618
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50983167
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48231055
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48231055
40ZFP281_27345836_Chip-Seq_ESCs_Mouse1.47071556
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44600484
42RING1B_27294783_Chip-Seq_NPCs_Mouse1.43581861
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42614890
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42111379
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.42086446
46* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.41102227
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40864180
48* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40695829
49VDR_21846776_ChIP-Seq_THP-1_Human1.40609781
50KDM2B_26808549_Chip-Seq_JURKAT_Human1.38737995
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37643499
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.37105267
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35273988
54* KDM2B_26808549_Chip-Seq_DND41_Human1.35077522
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33835452
56RARB_27405468_Chip-Seq_BRAIN_Mouse1.33709454
57* TCF7_22412390_ChIP-Seq_EML_Mouse1.33559115
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.32911090
59* RUNX1_27514584_Chip-Seq_MCF-7_Human1.32407182
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32278963
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.30861034
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.30842775
63* YY1_22570637_ChIP-Seq_MALME-3M_Human1.30354741
64REST_21632747_ChIP-Seq_MESCs_Mouse1.29313513
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28693518
66TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.28637382
67* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28147353
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27966689
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.26727581
70SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.26584247
71LXR_22292898_ChIP-Seq_THP-1_Human1.26071994
72* FOXP1_21924763_ChIP-Seq_HESCs_Human1.25846060
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.25316242
74CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.24784141
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23836172
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23662572
77CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22517191
78SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22185590
79CREB1_26743006_Chip-Seq_LNCaP_Human1.20837201
80NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20036186
81CTCF_27219007_Chip-Seq_Bcells_Human1.19500514
82EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19137701
83MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.18747524
84TP53_23651856_ChIP-Seq_MEFs_Mouse1.17852151
85* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17747785
86ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17312637
87TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.16839108
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16092577
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14745647
90EED_16625203_ChIP-ChIP_MESCs_Mouse1.14679381
91SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14098381
92TP63_22573176_ChIP-Seq_HFKS_Human1.13787021
93TP53_20018659_ChIP-ChIP_R1E_Mouse1.13583995
94ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13536747
95TET1_21490601_ChIP-Seq_MESCs_Mouse1.12524141
96SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12105247
97SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11777641
98PHF8_20622854_ChIP-Seq_HELA_Human1.11186064
99HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11126664
100CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09613165
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08898785
102SOX2_16153702_ChIP-ChIP_HESCs_Human1.07942536
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07416646
104* ISL1_27105846_Chip-Seq_CPCs_Mouse1.07372035
105RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06661514
106RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06401679
107SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05762558
108MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05324535
109* ELF1_20517297_ChIP-Seq_JURKAT_Human1.04903572
110SA1_27219007_Chip-Seq_ERYTHROID_Human1.04867294
111TRIM28_21343339_ChIP-Seq_HEK293_Human1.04730856
112TP53_22127205_ChIP-Seq_IMR90_Human1.04149901
113PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04006637
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02402853
115ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01798837
116TET1_21451524_ChIP-Seq_MESCs_Mouse1.01717867
117RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01184251
118SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01168595
119SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01070168
120ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99763167
121MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99721153
122* SOX3_22085726_ChIP-Seq_NPCs_Mouse0.99540725
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99294745
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98959047
125RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98680190
126SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97876631
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97779904
128* BCL6_27268052_Chip-Seq_Bcells_Human0.97757460
129TTF2_22483619_ChIP-Seq_HELA_Human0.97594659
130KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97305665
131WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97254025
132DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96957721
133YY1_21170310_ChIP-Seq_MESCs_Mouse0.96309813
134KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96035006
135KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96035006
136KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96035006
137CTCF_20526341_ChIP-Seq_ESCs_Human0.95999038
138KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94801339
139ELK3_25401928_ChIP-Seq_HUVEC_Human0.94355521

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.34612431
2MP0000778_abnormal_nervous_system2.76122885
3MP0004270_analgesia2.64186544
4MP0000566_synostosis2.52831858
5MP0000537_abnormal_urethra_morphology2.40903136
6MP0005410_abnormal_fertilization2.40626100
7MP0004859_abnormal_synaptic_plasticity2.33671569
8MP0003880_abnormal_central_pattern2.32222816
9MP0010030_abnormal_orbit_morphology2.24563914
10MP0005423_abnormal_somatic_nervous2.11719620
11MP0004885_abnormal_endolymph2.07857204
12MP0003705_abnormal_hypodermis_morpholog2.03627092
13MP0002249_abnormal_larynx_morphology2.03477690
14MP0003938_abnormal_ear_development1.96730090
15MP0009384_cardiac_valve_regurgitation1.88621628
16MP0005409_darkened_coat_color1.85962730
17MP0003119_abnormal_digestive_system1.80477687
18MP0003861_abnormal_nervous_system1.80197489
19MP0008789_abnormal_olfactory_epithelium1.78088001
20MP0001485_abnormal_pinna_reflex1.74556628
21MP0002234_abnormal_pharynx_morphology1.72168420
22MP0002184_abnormal_innervation1.68981216
23MP0000955_abnormal_spinal_cord1.68200396
24MP0003329_amyloid_beta_deposits1.67784861
25MP0002822_catalepsy1.64997723
26MP0003315_abnormal_perineum_morphology1.64410064
27MP0002102_abnormal_ear_morphology1.62341058
28MP0000462_abnormal_digestive_system1.61722642
29MP0002089_abnormal_postnatal_growth/wei1.52820232
30MP0006072_abnormal_retinal_apoptosis1.52578346
31MP0003878_abnormal_ear_physiology1.52375619
32MP0005377_hearing/vestibular/ear_phenot1.52375619
33MP0003698_abnormal_male_reproductive1.51869718
34MP0005394_taste/olfaction_phenotype1.50750641
35MP0005499_abnormal_olfactory_system1.50750641
36MP0000049_abnormal_middle_ear1.47090494
37MP0002882_abnormal_neuron_morphology1.44874160
38MP0004742_abnormal_vestibular_system1.41840686
39MP0003937_abnormal_limbs/digits/tail_de1.41211366
40MP0003787_abnormal_imprinting1.41046147
41MP0002734_abnormal_mechanical_nocicepti1.40174375
42MP0002152_abnormal_brain_morphology1.40087038
43MP0006276_abnormal_autonomic_nervous1.39359790
44MP0005623_abnormal_meninges_morphology1.39322108
45MP0003635_abnormal_synaptic_transmissio1.38515427
46MP0008932_abnormal_embryonic_tissue1.35737007
47MP0005076_abnormal_cell_differentiation1.34942319
48MP0008995_early_reproductive_senescence1.33140517
49MP0000920_abnormal_myelination1.32622142
50MP0000534_abnormal_ureter_morphology1.32509560
51MP0001502_abnormal_circadian_rhythm1.32416367
52MP0002751_abnormal_autonomic_nervous1.27684037
53MP0003122_maternal_imprinting1.26776579
54MP0003634_abnormal_glial_cell1.26754113
55MP0002752_abnormal_somatic_nervous1.25967026
56MP0001299_abnormal_eye_distance/1.22544868
57MP0001529_abnormal_vocalization1.21755474
58MP0004811_abnormal_neuron_physiology1.21606785
59MP0001188_hyperpigmentation1.20823933
60MP0003385_abnormal_body_wall1.20769779
61MP0000678_abnormal_parathyroid_gland1.20448602
62MP0000428_abnormal_craniofacial_morphol1.19954532
63MP0003755_abnormal_palate_morphology1.19388460
64MP0001929_abnormal_gametogenesis1.19074140
65MP0001849_ear_inflammation1.18478134
66MP0002063_abnormal_learning/memory/cond1.18394266
67MP0002085_abnormal_embryonic_tissue1.17977705
68MP0002733_abnormal_thermal_nociception1.17661293
69MP0004858_abnormal_nervous_system1.17459301
70MP0002210_abnormal_sex_determination1.17201723
71MP0001440_abnormal_grooming_behavior1.16539651
72MP0000467_abnormal_esophagus_morphology1.15894977
73MP0003121_genomic_imprinting1.15209979
74MP0000631_abnormal_neuroendocrine_gland1.14900384
75MP0001486_abnormal_startle_reflex1.14291606
76MP0002735_abnormal_chemical_nociception1.13634906
77MP0003136_yellow_coat_color1.11156342
78MP0002084_abnormal_developmental_patter1.10813544
79MP0002282_abnormal_trachea_morphology1.09777677
80MP0000733_abnormal_muscle_development1.08124552
81MP0000003_abnormal_adipose_tissue1.05865802
82MP0003879_abnormal_hair_cell1.05470323
83MP0003942_abnormal_urinary_system1.03706747
84MP0001730_embryonic_growth_arrest1.03092414
85MP0000026_abnormal_inner_ear1.02861381
86MP0001727_abnormal_embryo_implantation1.02625945
87MP0003935_abnormal_craniofacial_develop1.01973356
88MP0001145_abnormal_male_reproductive1.01780102
89MP0001346_abnormal_lacrimal_gland1.01779559
90MP0004133_heterotaxia1.00701483
91MP0000383_abnormal_hair_follicle1.00378832
92MP0004272_abnormal_basement_membrane0.99651537
93MP0009278_abnormal_bone_marrow0.99558893
94MP0001970_abnormal_pain_threshold0.98602999
95MP0002557_abnormal_social/conspecific_i0.98527326
96MP0001270_distended_abdomen0.98139077
97MP0008877_abnormal_DNA_methylation0.98053581
98MP0002081_perinatal_lethality0.95809652
99MP0002116_abnormal_craniofacial_bone0.94046593
100MP0009053_abnormal_anal_canal0.93551727
101MP0002161_abnormal_fertility/fecundity0.93496152
102MP0005508_abnormal_skeleton_morphology0.92968039
103MP0004957_abnormal_blastocyst_morpholog0.92745385
104MP0003115_abnormal_respiratory_system0.91899458
105MP0002909_abnormal_adrenal_gland0.91653078
106MP0000762_abnormal_tongue_morphology0.91250695
107MP0003283_abnormal_digestive_organ0.90883171
108MP0004145_abnormal_muscle_electrophysio0.90480790
109MP0002064_seizures0.89466999
110MP0002233_abnormal_nose_morphology0.89206553
111MP0009250_abnormal_appendicular_skeleto0.88733370
112MP0002697_abnormal_eye_size0.88009494
113MP0002177_abnormal_outer_ear0.87597530
114MP0001348_abnormal_lacrimal_gland0.87028128
115MP0002932_abnormal_joint_morphology0.85849177
116MP0002066_abnormal_motor_capabilities/c0.85171682
117MP0005257_abnormal_intraocular_pressure0.84866117
118MP0002092_abnormal_eye_morphology0.84712319
119MP0008961_abnormal_basal_metabolism0.84613335
120MP0002572_abnormal_emotion/affect_behav0.83977264
121MP0003890_abnormal_embryonic-extraembry0.83839510
122MP0005187_abnormal_penis_morphology0.83749662
123MP0002098_abnormal_vibrissa_morphology0.83103198
124MP0000432_abnormal_head_morphology0.82690902
125MP0002272_abnormal_nervous_system0.82653708
126MP0001905_abnormal_dopamine_level0.82514027
127MP0003123_paternal_imprinting0.82487932
128MP0005503_abnormal_tendon_morphology0.82385620
129MP0005248_abnormal_Harderian_gland0.81484217
130MP0005058_abnormal_lysosome_morphology0.81440005
131MP0002111_abnormal_tail_morphology0.80782935
132MP0000579_abnormal_nail_morphology0.80077596
133MP0003172_abnormal_lysosome_physiology0.79939584
134MP0003948_abnormal_gas_homeostasis0.77734918
135MP0000538_abnormal_urinary_bladder0.76565147
136MP0002114_abnormal_axial_skeleton0.73514466
137MP0001968_abnormal_touch/_nociception0.71689992

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)4.15126190
2Split foot (HP:0001839)3.03573719
3Cervical subluxation (HP:0003308)2.93442817
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.78557594
5Degeneration of the lateral corticospinal tracts (HP:0002314)2.78557594
6Shoulder girdle muscle weakness (HP:0003547)2.73042673
7Concave nail (HP:0001598)2.72256420
8Abnormality of the aortic arch (HP:0012303)2.69215489
9Megalencephaly (HP:0001355)2.66018078
10Supranuclear gaze palsy (HP:0000605)2.60243821
11Broad distal phalanx of finger (HP:0009836)2.59847094
12Amyotrophic lateral sclerosis (HP:0007354)2.58527247
13Abnormality of the corticospinal tract (HP:0002492)2.56402094
14Obstructive sleep apnea (HP:0002870)2.53313735
15Trigonocephaly (HP:0000243)2.51245922
16Broad face (HP:0000283)2.47750606
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.46878059
18Deep palmar crease (HP:0006191)2.44533702
19Neurofibrillary tangles (HP:0002185)2.44527040
20Alacrima (HP:0000522)2.44134183
21Overriding aorta (HP:0002623)2.41433663
22Peripheral hypomyelination (HP:0007182)2.41197902
23Vitreoretinal degeneration (HP:0000655)2.40501846
24Morphological abnormality of the middle ear (HP:0008609)2.39630373
25Hypoplastic pelvis (HP:0008839)2.39245709
26Hand muscle atrophy (HP:0009130)2.37576299
27Upper limb amyotrophy (HP:0009129)2.36873168
28Distal upper limb amyotrophy (HP:0007149)2.36873168
29Ankle clonus (HP:0011448)2.35960867
30Turricephaly (HP:0000262)2.34375711
31Rib fusion (HP:0000902)2.29620297
32Anteriorly placed anus (HP:0001545)2.28941265
33Myokymia (HP:0002411)2.25443597
34Abnormality of the intervertebral disk (HP:0005108)2.25283263
35Absent/shortened dynein arms (HP:0200106)2.25192382
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.25192382
37Atelectasis (HP:0100750)2.23671896
38Spastic gait (HP:0002064)2.23021660
39Retinal dysplasia (HP:0007973)2.22646568
40Cerebral inclusion bodies (HP:0100314)2.22522809
41Bronchomalacia (HP:0002780)2.21129765
42Broad metatarsal (HP:0001783)2.20753547
43Hypoplasia of the brainstem (HP:0002365)2.16789337
44Aplasia/Hypoplasia of the brainstem (HP:0007362)2.16789337
45Ulnar bowing (HP:0003031)2.15822084
46Short 4th metacarpal (HP:0010044)2.15007142
47Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.15007142
48Insomnia (HP:0100785)2.13361668
49Long toe (HP:0010511)2.11679096
50Renovascular hypertension (HP:0100817)2.10664106
51Genetic anticipation (HP:0003743)2.09978595
52Long palpebral fissure (HP:0000637)2.09800327
53Vertebral arch anomaly (HP:0008438)2.08591466
54Achilles tendon contracture (HP:0001771)2.08312413
55Pelvic girdle muscle weakness (HP:0003749)2.07684267
56Cerebral aneurysm (HP:0004944)2.06842141
57Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.05842424
58Shawl scrotum (HP:0000049)2.05681604
59Neonatal short-limb short stature (HP:0008921)2.05323862
60Abnormality of the musculature of the pelvis (HP:0001469)2.05187523
61Abnormality of the hip-girdle musculature (HP:0001445)2.05187523
62Truncus arteriosus (HP:0001660)2.04630427
63Thin bony cortex (HP:0002753)2.04142974
64Lissencephaly (HP:0001339)2.03530888
65Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.98120185
66Amblyopia (HP:0000646)1.97088240
67Flattened epiphyses (HP:0003071)1.95573472
68CNS hypomyelination (HP:0003429)1.95101761
69Delusions (HP:0000746)1.94850230
70Flat capital femoral epiphysis (HP:0003370)1.94635056
71Decreased lacrimation (HP:0000633)1.93876428
72Occipital encephalocele (HP:0002085)1.93771941
73Difficulty climbing stairs (HP:0003551)1.91919574
74Nasal polyposis (HP:0100582)1.90887094
75Fragile nails (HP:0001808)1.88239612
76Tented upper lip vermilion (HP:0010804)1.87801865
77Down-sloping shoulders (HP:0200021)1.87571813
78Abnormality of the lower motor neuron (HP:0002366)1.87554021
79Hypoventilation (HP:0002791)1.87336127
80Elfin facies (HP:0004428)1.86010314
81Stenosis of the external auditory canal (HP:0000402)1.85368511
82Short femoral neck (HP:0100864)1.85267215
83Hyperacusis (HP:0010780)1.84514839
84Atrophic scars (HP:0001075)1.83934357
85Supernumerary ribs (HP:0005815)1.83389586
86Bladder diverticulum (HP:0000015)1.82901493
87Absent hand (HP:0004050)1.82437095
88Atrophy/Degeneration involving motor neurons (HP:0007373)1.82334067
89Aplasia/hypoplasia of the uterus (HP:0008684)1.82179261
90Aplasia/Hypoplasia of the patella (HP:0006498)1.81195825
91Muscle fiber splitting (HP:0003555)1.81128972
92Aplasia involving bones of the upper limbs (HP:0009823)1.81030751
93Aplasia of the phalanges of the hand (HP:0009802)1.81030751
94Aplasia involving bones of the extremities (HP:0009825)1.81030751
95Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.80039932
96Tracheomalacia (HP:0002779)1.78525074
97Type II lissencephaly (HP:0007260)1.78402436
98Parakeratosis (HP:0001036)1.78161410
99Hypoplastic ischia (HP:0003175)1.76837840
100Mutism (HP:0002300)1.76415183
101Abnormality of the labia minora (HP:0012880)1.76345655
102Protrusio acetabuli (HP:0003179)1.75821154
103Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75324480
104Absent epiphyses (HP:0010577)1.75324480
105Sensory axonal neuropathy (HP:0003390)1.75295100
106Horseshoe kidney (HP:0000085)1.74184217
107Premature rupture of membranes (HP:0001788)1.74125025
108Patellar aplasia (HP:0006443)1.74105713
109Neoplasm of the heart (HP:0100544)1.73937869
110Akinesia (HP:0002304)1.72351602
111Breast hypoplasia (HP:0003187)1.72042810
112Biconcave vertebral bodies (HP:0004586)1.71648197
113Male infertility (HP:0003251)1.70664212
114Meningocele (HP:0002435)1.69999550
115Shallow orbits (HP:0000586)1.69746625
116Spina bifida occulta (HP:0003298)1.68856272
117Flat acetabular roof (HP:0003180)1.68318498
118Supernumerary bones of the axial skeleton (HP:0009144)1.67810183
119Optic nerve coloboma (HP:0000588)1.67779810
120Secondary amenorrhea (HP:0000869)1.67413613
121Renal duplication (HP:0000075)1.67273139
122Precocious puberty (HP:0000826)1.67074343
123Large eyes (HP:0001090)1.66938113
124Cystic liver disease (HP:0006706)1.66256205
125Abnormality of the 4th metacarpal (HP:0010012)1.66065827
126Partial agenesis of the corpus callosum (HP:0001338)1.65967879
127Abnormality of the musculature of the hand (HP:0001421)1.65794209
128Fibular aplasia (HP:0002990)1.64932666
129Abnormal ciliary motility (HP:0012262)1.64685237
130Absent forearm bone (HP:0003953)1.64082259
131Aplasia involving forearm bones (HP:0009822)1.64082259
132Mitral regurgitation (HP:0001653)1.63744375
133Renal dysplasia (HP:0000110)1.63542461
134Broad phalanges of the hand (HP:0009768)1.63232020
135Abnormality of the nasal mucosa (HP:0000433)1.63184817
136Morphological abnormality of the inner ear (HP:0011390)1.62746450
137Polymicrogyria (HP:0002126)1.62358824
138Absent radius (HP:0003974)1.61660515
139Aplasia/hypoplasia of the femur (HP:0005613)1.61297862
140Abnormality of the fingertips (HP:0001211)1.61290900
141Sleep apnea (HP:0010535)1.61222353
142Facial hemangioma (HP:0000329)1.61037630
143Abnormality of the diencephalon (HP:0010662)1.60826024
144Abnormal respiratory motile cilium physiology (HP:0012261)1.60791474
145Narrow nasal bridge (HP:0000446)1.60781640
146Megalocornea (HP:0000485)1.60779377
147Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.60739995
148Ventricular fibrillation (HP:0001663)1.60491686
149Broad finger (HP:0001500)1.60489306
150Thin ribs (HP:0000883)1.60335664
151Pointed chin (HP:0000307)1.60237328
152Hypertensive crisis (HP:0100735)1.59827738
153Abnormality of the Achilles tendon (HP:0005109)1.59481500
154Bell-shaped thorax (HP:0001591)1.58884146
155Abnormal pancreas size (HP:0012094)1.58631680
156Patellar dislocation (HP:0002999)1.58551119
157Chin dimple (HP:0010751)1.57825853
158Bowel incontinence (HP:0002607)1.57802746
159High anterior hairline (HP:0009890)1.57791262
160Bowed forearm bones (HP:0003956)1.57639029
161Bowing of the arm (HP:0006488)1.57639029
162Cutaneous finger syndactyly (HP:0010554)1.57107669
163Arnold-Chiari malformation (HP:0002308)1.56981759
164Buphthalmos (HP:0000557)1.56969071
165Abnormality of dentin (HP:0010299)1.56726195
166Nephronophthisis (HP:0000090)1.56254484
167Myopathic facies (HP:0002058)1.56181777
168Morphological abnormality of the pyramidal tract (HP:0002062)1.55857369
169Insidious onset (HP:0003587)1.55808151
170Termporal pattern (HP:0011008)1.55808151
171Short nail (HP:0001799)1.55601910
172Abnormal respiratory epithelium morphology (HP:0012253)1.54753998
173Abnormal respiratory motile cilium morphology (HP:0005938)1.54753998
174Trismus (HP:0000211)1.54446453
175Abnormality of the shoulder girdle musculature (HP:0001435)1.54263159

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.43082402
2ICK3.40283586
3TLK13.14748084
4LIMK12.77671765
5TESK22.61957297
6TESK12.53651143
7STK392.53467687
8SIK12.48757122
9BUB12.44620261
10CDK192.44226793
11PAK62.43227122
12UHMK12.42721935
13DYRK22.17237154
14MAP3K92.07486812
15TYRO32.07220789
16PNCK2.03324682
17SRPK11.98859521
18EPHA21.85808782
19KSR11.79105621
20BCR1.76915708
21PKN21.75496663
22LMTK21.68012068
23EPHB21.66895067
24CDK121.52820680
25EEF2K1.52147107
26MAP4K21.51760289
27TNIK1.51500543
28OXSR11.50834750
29RPS6KA21.49090699
30DYRK31.46358558
31PRKD21.43141567
32DYRK1B1.42636408
33WNK41.41204649
34KSR21.35194733
35MAP2K21.33877521
36PRKD31.31464257
37PAK31.30744669
38CDK141.27636221
39CDK151.14980998
40MTOR1.13986931
41ARAF1.12983437
42CDK181.12709266
43ERN11.11576723
44MAP3K71.10297658
45CDK11A1.10261544
46FGFR41.09887808
47MAP2K71.09283435
48CSNK1G31.08774779
49TRIB31.08119800
50CASK1.07935686
51LATS21.06000950
52MAP3K101.04413364
53CSNK1A1L1.03411321
54CDC42BPA1.03190645
55AURKA1.02967583
56MET1.02799605
57NTRK11.02131852
58ROCK21.01093694
59ALK1.00703512
60PAK11.00607572
61MINK11.00554371
62NTRK20.97612610
63PTK60.97261201
64DAPK30.93154859
65MAP3K60.90071833
66MARK20.88322228
67ILK0.87628100
68SMG10.87286985
69CSNK1G20.84221830
70MAP2K40.83789177
71WNK30.83729075
72BRAF0.83411729
73CDK50.82939172
74MKNK20.82795848
75FGR0.80651939
76CAMKK10.79319610
77NTRK30.79073564
78EPHA30.77240907
79DMPK0.77227721
80DDR20.77179757
81CAMK1G0.76507370
82SIK20.76333833
83CAMK1D0.73414996
84MAP2K60.73066004
85MAPK130.72519531
86WEE10.72167802
87BMX0.71833925
88PKN10.71804147
89MKNK10.71769089
90RPS6KC10.71316049
91RPS6KL10.71316049
92MAPK150.70166804
93SIK30.69612135
94NME10.69372871
95PAK20.68350106
96FGFR20.68244660
97PTK20.68064552
98MAP3K110.67015536
99EPHA40.66508909
100STK160.65996424
101MST1R0.65412509
102RPS6KA60.64987021
103IRAK20.61737052
104EPHB10.61495264
105SGK4940.60780701
106SGK2230.60780701
107ROCK10.57803734
108DYRK1A0.57745203
109CSNK1G10.56880726
110PAK40.56443673
111CSNK1E0.56317448
112TAOK20.53474794
113RIPK10.53063195
114ERBB20.53042809
115NEK20.52352245
116RET0.52208915
117CAMK2B0.51376543
118PRKCI0.51163861
119PDGFRA0.50291674
120PDK40.49934730
121PDK30.49934730
122MAPK90.49520540
123FER0.49092603
124PRKCH0.48691938
125MAPK80.48432994
126DAPK20.48159483
127STK380.48042531
128MAPKAPK30.46996817
129PRKAA10.46719508
130BRD40.46535666
131HIPK20.45062726
132MOS0.44579848
133WNK10.44549870
134PRKD10.43708491
135MST40.42357489
136PRKCZ0.41932098
137INSRR0.41632446
138CHUK0.41508270
139STK110.40470453
140MAP3K40.39555771
141SRC0.38977959
142TNK20.38295163
143RPS6KB20.35576397
144LRRK20.33282980
145EIF2AK10.32541697
146PDGFRB0.32299296
147TAOK10.32216673
148BRSK10.31827896
149ERBB30.31048993
150PRPF4B0.30308630

Predicted pathways (KEGG)

RankGene SetZ-score
1Axon guidance_Homo sapiens_hsa043602.62021018
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.54557884
3Spliceosome_Homo sapiens_hsa030402.16270040
4Renal cell carcinoma_Homo sapiens_hsa052111.99706329
5Oocyte meiosis_Homo sapiens_hsa041141.91051150
6RNA polymerase_Homo sapiens_hsa030201.85735165
7Glycosaminoglycan degradation_Homo sapiens_hsa005311.84514296
8Ribosome_Homo sapiens_hsa030101.74937534
9Hedgehog signaling pathway_Homo sapiens_hsa043401.65370410
10Hippo signaling pathway_Homo sapiens_hsa043901.62764710
11Sulfur relay system_Homo sapiens_hsa041221.61590531
12Proteasome_Homo sapiens_hsa030501.56972839
13Nicotine addiction_Homo sapiens_hsa050331.54915138
14Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.54824279
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53680069
16Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.50854818
17Tight junction_Homo sapiens_hsa045301.49415940
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46655402
19Basal cell carcinoma_Homo sapiens_hsa052171.45989103
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.45234488
21mRNA surveillance pathway_Homo sapiens_hsa030151.43340799
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40714818
23RNA transport_Homo sapiens_hsa030131.38363604
24ECM-receptor interaction_Homo sapiens_hsa045121.33578369
25Wnt signaling pathway_Homo sapiens_hsa043101.32917564
26VEGF signaling pathway_Homo sapiens_hsa043701.29847704
27Gap junction_Homo sapiens_hsa045401.29375700
28ErbB signaling pathway_Homo sapiens_hsa040121.26829008
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23643077
30* Endocytosis_Homo sapiens_hsa041441.23064723
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.22780760
32Lysine degradation_Homo sapiens_hsa003101.20355006
33Synaptic vesicle cycle_Homo sapiens_hsa047211.18311171
34Notch signaling pathway_Homo sapiens_hsa043301.17274219
35Estrogen signaling pathway_Homo sapiens_hsa049151.17181337
36Other glycan degradation_Homo sapiens_hsa005111.17060973
37Alcoholism_Homo sapiens_hsa050341.16328494
38Steroid biosynthesis_Homo sapiens_hsa001001.15489004
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15409343
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15200643
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13833915
42Vibrio cholerae infection_Homo sapiens_hsa051101.12198445
43Cardiac muscle contraction_Homo sapiens_hsa042601.11971759
44Melanogenesis_Homo sapiens_hsa049161.10384790
45Dopaminergic synapse_Homo sapiens_hsa047281.09636707
46Bladder cancer_Homo sapiens_hsa052191.07780111
47Adherens junction_Homo sapiens_hsa045201.07694710
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05171077
49Colorectal cancer_Homo sapiens_hsa052101.03219177
50Huntingtons disease_Homo sapiens_hsa050161.00433165
51Dilated cardiomyopathy_Homo sapiens_hsa054140.98290102
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97854521
53AMPK signaling pathway_Homo sapiens_hsa041520.97717612
54Long-term potentiation_Homo sapiens_hsa047200.97121573
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.96497659
56Parkinsons disease_Homo sapiens_hsa050120.94265792
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92402290
58Glioma_Homo sapiens_hsa052140.92045005
59Cell cycle_Homo sapiens_hsa041100.91932375
60Glutamatergic synapse_Homo sapiens_hsa047240.91085618
61Basal transcription factors_Homo sapiens_hsa030220.90130480
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90128893
63Endometrial cancer_Homo sapiens_hsa052130.90077865
64Oxidative phosphorylation_Homo sapiens_hsa001900.89509106
65Phototransduction_Homo sapiens_hsa047440.88696808
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88233087
67Acute myeloid leukemia_Homo sapiens_hsa052210.87310505
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87216892
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86772541
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85576815
71Long-term depression_Homo sapiens_hsa047300.84141222
72GnRH signaling pathway_Homo sapiens_hsa049120.83207878
73Dorso-ventral axis formation_Homo sapiens_hsa043200.83012556
74Prolactin signaling pathway_Homo sapiens_hsa049170.82849221
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82640696
76* Phospholipase D signaling pathway_Homo sapiens_hsa040720.82115833
77Epstein-Barr virus infection_Homo sapiens_hsa051690.81743334
78Cholinergic synapse_Homo sapiens_hsa047250.81643995
79Cocaine addiction_Homo sapiens_hsa050300.80897278
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.80235196
81Choline metabolism in cancer_Homo sapiens_hsa052310.80099732
82Alzheimers disease_Homo sapiens_hsa050100.79812301
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79199817
84cAMP signaling pathway_Homo sapiens_hsa040240.76908904
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75968200
86Ether lipid metabolism_Homo sapiens_hsa005650.74804880
87MicroRNAs in cancer_Homo sapiens_hsa052060.74752716
88Proteoglycans in cancer_Homo sapiens_hsa052050.74125479
89Protein digestion and absorption_Homo sapiens_hsa049740.74072090
90Oxytocin signaling pathway_Homo sapiens_hsa049210.73635731
91ABC transporters_Homo sapiens_hsa020100.73016581
92Inositol phosphate metabolism_Homo sapiens_hsa005620.72903160
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72901274
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71974283
95Salivary secretion_Homo sapiens_hsa049700.71585060
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.71483757
97Morphine addiction_Homo sapiens_hsa050320.70485850
98Type II diabetes mellitus_Homo sapiens_hsa049300.70260663
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69958698
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69473184
101Ras signaling pathway_Homo sapiens_hsa040140.69400666
102Insulin signaling pathway_Homo sapiens_hsa049100.69363361
103Taste transduction_Homo sapiens_hsa047420.68926560
104Chronic myeloid leukemia_Homo sapiens_hsa052200.68290176
105Prostate cancer_Homo sapiens_hsa052150.68132159
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66989276
107Shigellosis_Homo sapiens_hsa051310.66199264
108Vitamin B6 metabolism_Homo sapiens_hsa007500.64832290
109Amphetamine addiction_Homo sapiens_hsa050310.64202141
110Thyroid hormone synthesis_Homo sapiens_hsa049180.63343726
111Hepatitis C_Homo sapiens_hsa051600.63255071
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62849616
113Circadian entrainment_Homo sapiens_hsa047130.62172360
114Gastric acid secretion_Homo sapiens_hsa049710.62141200
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61976020
116Insulin secretion_Homo sapiens_hsa049110.61450437
117Prion diseases_Homo sapiens_hsa050200.61306415
118GABAergic synapse_Homo sapiens_hsa047270.60556364
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.59639344
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.59523892
121Bile secretion_Homo sapiens_hsa049760.59347373
122MAPK signaling pathway_Homo sapiens_hsa040100.58914300
123Focal adhesion_Homo sapiens_hsa045100.58458122
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58147639
125TGF-beta signaling pathway_Homo sapiens_hsa043500.58135646
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58041407
127T cell receptor signaling pathway_Homo sapiens_hsa046600.57318635
128Rap1 signaling pathway_Homo sapiens_hsa040150.56137461
129mTOR signaling pathway_Homo sapiens_hsa041500.55779806
130Non-small cell lung cancer_Homo sapiens_hsa052230.55480182
131Pathways in cancer_Homo sapiens_hsa052000.55429877
132Protein export_Homo sapiens_hsa030600.55126770
133Serotonergic synapse_Homo sapiens_hsa047260.54060933
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.53845117
135N-Glycan biosynthesis_Homo sapiens_hsa005100.53006700
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52483569
137Viral carcinogenesis_Homo sapiens_hsa052030.52004921
138Salmonella infection_Homo sapiens_hsa051320.51898234
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51204779
140Sphingolipid metabolism_Homo sapiens_hsa006000.51152199

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