CYTH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.33682380
2antigen processing and presentation of endogenous antigen (GO:0019883)4.89307225
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.74114442
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.74114442
5regulation of gamma-delta T cell differentiation (GO:0045586)4.32247914
6detection of other organism (GO:0098543)4.26911800
7detection of bacterium (GO:0016045)4.21849421
8positive thymic T cell selection (GO:0045059)4.11307425
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.04222938
10negative regulation of cell killing (GO:0031342)4.04222938
11regulation of gamma-delta T cell activation (GO:0046643)4.03552855
12B cell receptor signaling pathway (GO:0050853)3.99102808
13negative thymic T cell selection (GO:0045060)3.98721268
14negative T cell selection (GO:0043383)3.92768215
15negative regulation of lymphocyte mediated immunity (GO:0002707)3.90280649
16negative regulation of interleukin-12 production (GO:0032695)3.84200058
17negative regulation of T cell mediated immunity (GO:0002710)3.78313755
18response to peptidoglycan (GO:0032494)3.71018299
19regulation of interleukin-12 biosynthetic process (GO:0045075)3.69822367
20negative regulation of erythrocyte differentiation (GO:0045647)3.62946501
21immunoglobulin mediated immune response (GO:0016064)3.61226175
22cellular response to type I interferon (GO:0071357)3.59790744
23type I interferon signaling pathway (GO:0060337)3.59790744
24cellular extravasation (GO:0045123)3.58593404
25response to type I interferon (GO:0034340)3.58240674
26positive T cell selection (GO:0043368)3.57083502
27thymic T cell selection (GO:0045061)3.56459265
28negative regulation of leukocyte mediated immunity (GO:0002704)3.53896753
29regulation of B cell receptor signaling pathway (GO:0050855)3.52437326
30T cell selection (GO:0045058)3.48126384
31detection of external biotic stimulus (GO:0098581)3.46757300
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.46581899
33positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.43454237
34regulation of tolerance induction (GO:0002643)3.40519851
35response to interleukin-15 (GO:0070672)3.19068478
36positive regulation of B cell differentiation (GO:0045579)3.17723609
37T cell migration (GO:0072678)3.13235982
38NIK/NF-kappaB signaling (GO:0038061)3.13150991
39positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.13141023
40response to host immune response (GO:0052572)3.10320423
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.10320423
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.05743668
43detection of molecule of bacterial origin (GO:0032490)3.04216544
44tolerance induction (GO:0002507)3.03320023
45respiratory burst (GO:0045730)3.02627444
46positive regulation of Rap GTPase activity (GO:0032854)3.01679237
47regulation of natural killer cell mediated immunity (GO:0002715)3.00909526
48regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.00909526
49detection of biotic stimulus (GO:0009595)3.00726349
50positive regulation of tolerance induction (GO:0002645)3.00461703
51JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.00406050
52response to protozoan (GO:0001562)2.98699203
53regulation of B cell differentiation (GO:0045577)2.97356818
54positive regulation of interleukin-2 production (GO:0032743)2.97073909
55antigen processing and presentation via MHC class Ib (GO:0002475)2.96394664
56response to host (GO:0075136)2.96121296
57response to host defenses (GO:0052200)2.96121296
58response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.96121296
59positive regulation of granulocyte differentiation (GO:0030854)2.94952179
60sodium ion export (GO:0071436)2.93541064
61positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.93451256
62regulation of T cell mediated cytotoxicity (GO:0001914)2.92161538
63negative regulation of innate immune response (GO:0045824)2.91792955
64B cell homeostasis (GO:0001782)2.89238430
65regulation of mast cell degranulation (GO:0043304)2.89092129
66activated T cell proliferation (GO:0050798)2.88680482
67negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.87951971
68cellular response to interleukin-15 (GO:0071350)2.87468813
69microglial cell activation (GO:0001774)2.86816791
70regulation of antigen processing and presentation (GO:0002577)2.84548815
71macrophage activation (GO:0042116)2.78224865
72B cell mediated immunity (GO:0019724)2.77850674
73positive regulation of humoral immune response (GO:0002922)2.77265219
74antigen receptor-mediated signaling pathway (GO:0050851)2.77184431
75cellular response to zinc ion (GO:0071294)2.76848822
76regulation of T-helper 2 cell differentiation (GO:0045628)2.76057075
77regulation of ARF GTPase activity (GO:0032312)2.73249887
78negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.73213399
79myeloid dendritic cell differentiation (GO:0043011)2.71697889
80regulation of T cell tolerance induction (GO:0002664)2.71126208
81positive regulation of histone deacetylation (GO:0031065)2.70774706
82regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.69744325
83T cell costimulation (GO:0031295)2.68493391
84regulation of Rap GTPase activity (GO:0032317)2.67563143
85regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.66846263
86natural killer cell differentiation (GO:0001779)2.65210263
87mature B cell differentiation (GO:0002335)2.63339504
88leukocyte aggregation (GO:0070486)2.61930388
89lymphocyte costimulation (GO:0031294)2.61408935
90regulation of alpha-beta T cell proliferation (GO:0046640)2.58615799
91T cell receptor signaling pathway (GO:0050852)2.57118958
92negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.52410134
93myeloid dendritic cell activation (GO:0001773)2.51450065
94* regulation of ARF protein signal transduction (GO:0032012)2.49693994
95mast cell activation (GO:0045576)2.47607178
96regulation of regulatory T cell differentiation (GO:0045589)2.44287027
97protein localization to endosome (GO:0036010)2.44279101
98positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.43753119
99neutrophil activation (GO:0042119)2.38912614
100positive regulation of T cell cytokine production (GO:0002726)2.37396041
101positive regulation of antigen processing and presentation (GO:0002579)2.36719060
102interferon-gamma-mediated signaling pathway (GO:0060333)2.36712727
103regulation of interferon-beta biosynthetic process (GO:0045357)2.36471321
104macrophage activation involved in immune response (GO:0002281)2.33637309
105mast cell activation involved in immune response (GO:0002279)2.32687546
106mast cell degranulation (GO:0043303)2.32687546
107negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.31906764
108nerve growth factor signaling pathway (GO:0038180)2.31728820
109neutrophil activation involved in immune response (GO:0002283)2.30909852
110immune response-activating cell surface receptor signaling pathway (GO:0002429)2.30881970
111creatine metabolic process (GO:0006600)2.30278204
112potassium ion import (GO:0010107)2.28320164
113granulocyte activation (GO:0036230)2.27976308
114regulation of dendritic cell antigen processing and presentation (GO:0002604)2.27146770
115regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.22514278
116positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.22437024
117myeloid cell activation involved in immune response (GO:0002275)2.21674664
118positive regulation by symbiont of host defense response (GO:0052509)2.21125036
119modulation by symbiont of host defense response (GO:0052031)2.21125036
120modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.21125036
121modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.21125036
122positive regulation by organism of defense response of other organism involved in symbiotic interact2.21125036
123modulation by symbiont of host immune response (GO:0052553)2.21125036
124response to muramyl dipeptide (GO:0032495)2.20726028
125synaptic vesicle maturation (GO:0016188)2.19913726
126positive regulation of interleukin-12 production (GO:0032735)2.19666584
127regulation of T cell receptor signaling pathway (GO:0050856)2.18692052
128cellular potassium ion homeostasis (GO:0030007)2.18674104
129positive regulation of alpha-beta T cell proliferation (GO:0046641)2.15849824
130interferon-gamma production (GO:0032609)2.15031392
131Peyers patch development (GO:0048541)2.14738564
132mucosal-associated lymphoid tissue development (GO:0048537)2.14738564
133regulation of interleukin-2 biosynthetic process (GO:0045076)2.14696403
134lymphocyte migration (GO:0072676)2.14682783
135regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.14214657
136growth hormone receptor signaling pathway (GO:0060396)2.11939207
137serine transport (GO:0032329)2.11875551
138germinal center formation (GO:0002467)2.11675594
139JAK-STAT cascade (GO:0007259)2.10804806
140defense response to protozoan (GO:0042832)2.08612741
141T cell proliferation (GO:0042098)2.08336128
142regulation of interleukin-2 production (GO:0032663)2.08307815

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.19648230
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.97647781
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.54412482
4* RUNX_20019798_ChIP-Seq_JUKART_Human2.80225032
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.46264743
6VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.45233946
7FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.42404225
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.36711796
9* IRF8_27001747_Chip-Seq_BMDM_Mouse2.35682460
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32870230
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23676393
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.21671868
13SPI1_23547873_ChIP-Seq_NB4_Human2.20085110
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.19162453
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.14987090
16KDM2B_26808549_Chip-Seq_SUP-B15_Human2.13606543
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.13443459
18MYC_22102868_ChIP-Seq_BL_Human2.12939691
19* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03875682
20KDM2B_26808549_Chip-Seq_DND41_Human2.00489431
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97079554
22* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93571291
23VDR_21846776_ChIP-Seq_THP-1_Human1.91932328
24MAF_26560356_Chip-Seq_TH1_Human1.89121840
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.86597466
26TCF7_22412390_ChIP-Seq_EML_Mouse1.80557607
27SPI1_23127762_ChIP-Seq_K562_Human1.76394708
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.71407104
29DROSHA_22980978_ChIP-Seq_HELA_Human1.70954428
30MYB_26560356_Chip-Seq_TH2_Human1.67114310
31SCL_19346495_ChIP-Seq_HPC-7_Human1.63429401
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62935496
33NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.62536168
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59594823
35UTX_26944678_Chip-Seq_JUKART_Human1.58993828
36VDR_24763502_ChIP-Seq_THP-1_Human1.58649012
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55647952
38GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53275732
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.49979092
40MYB_26560356_Chip-Seq_TH1_Human1.49356268
41* RXR_22158963_ChIP-Seq_LIVER_Mouse1.43352074
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39639026
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39593557
44* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37560849
45* LXR_22158963_ChIP-Seq_LIVER_Mouse1.37555030
46* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.36800540
47VDR_24787735_ChIP-Seq_THP-1_Human1.36514278
48GATA3_27048872_Chip-Seq_THYMUS_Human1.36302390
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35808400
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35258389
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.35226856
52* KDM2B_26808549_Chip-Seq_JURKAT_Human1.34940412
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34143551
54* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33398340
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33213513
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32557050
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31245791
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.27776818
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26954949
60* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26303494
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22508705
62AR_21572438_ChIP-Seq_LNCaP_Human1.22391387
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22267903
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.22099331
65GATA1_19941826_ChIP-Seq_K562_Human1.21716304
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21637442
67LXR_22292898_ChIP-Seq_THP-1_Human1.21566058
68KDM2B_26808549_Chip-Seq_K562_Human1.21229578
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20162946
70RARB_27405468_Chip-Seq_BRAIN_Mouse1.19437175
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18659857
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17974407
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17912937
74MAF_26560356_Chip-Seq_TH2_Human1.17011765
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16891858
76* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15011346
77RUNX1_22412390_ChIP-Seq_EML_Mouse1.13610992
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12814714
79CIITA_25753668_ChIP-Seq_RAJI_Human1.12739145
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11807512
81* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08514456
82FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06910097
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05901431
84* GATA2_21666600_ChIP-Seq_HMVEC_Human1.04789884
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04110747
86* ELK3_25401928_ChIP-Seq_HUVEC_Human1.03921393
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03836005
88GATA2_19941826_ChIP-Seq_K562_Human1.02714526
89* FOXA2_19822575_ChIP-Seq_HepG2_Human1.00784268
90* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99640474
91NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99507881
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99451488
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99404703
94FOXO3_23340844_ChIP-Seq_DLD1_Human0.99392565
95* PU_27001747_Chip-Seq_BMDM_Mouse0.99344092
96NCOR1_26117541_ChIP-Seq_K562_Human0.98974571
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97804617
98ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95768020
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95078991
100BCL6_27268052_Chip-Seq_Bcells_Human0.94508665
101BCOR_27268052_Chip-Seq_Bcells_Human0.94374454
102SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92011066
103EGR1_19032775_ChIP-ChIP_M12_Human0.91146965
104EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90216415
105RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88979029
106PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.88793338
107RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88580191
108STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88359442
109* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.88009197
110PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87781758
111GATA1_22025678_ChIP-Seq_K562_Human0.86545406
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85450605
113GATA3_26560356_Chip-Seq_TH2_Human0.83635519
114MTF2_20144788_ChIP-Seq_MESCs_Mouse0.83512407
115ELF1_20517297_ChIP-Seq_JURKAT_Human0.83509715
116SA1_27219007_Chip-Seq_ERYTHROID_Human0.82538951
117* TBX20_22328084_ChIP-Seq_HEART_Mouse0.81809233
118* TBX20_22080862_ChIP-Seq_HEART_Mouse0.81809233
119LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.79809450
120ESR1_20079471_ChIP-ChIP_T-47D_Human0.78768194
121LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.78484193
122CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77386565
123ESR2_21235772_ChIP-Seq_MCF-7_Human0.77259810
124SUZ12_27294783_Chip-Seq_ESCs_Mouse0.75960860
125NR3C1_23031785_ChIP-Seq_PC12_Mouse0.73684237
126SMRT_27268052_Chip-Seq_Bcells_Human0.73599902
127ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.72864061
128CTCF_27219007_Chip-Seq_ERYTHROID_Human0.69794420

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.41558695
2MP0004510_myositis3.30990288
3MP0000685_abnormal_immune_system3.21822015
4MP0003303_peritoneal_inflammation3.20926492
5MP0005387_immune_system_phenotype3.07284891
6MP0001790_abnormal_immune_system3.07284891
7MP0001800_abnormal_humoral_immune2.97453244
8MP0005671_abnormal_response_to2.58798055
9MP0005000_abnormal_immune_tolerance2.56274294
10MP0003436_decreased_susceptibility_to2.37428120
11MP0002452_abnormal_antigen_presenting2.36893907
12MP0002723_abnormal_immune_serum2.36092959
13MP0003763_abnormal_thymus_physiology2.19993473
14MP0003300_gastrointestinal_ulcer2.19271027
15MP0002420_abnormal_adaptive_immunity2.16763935
16MP0001819_abnormal_immune_cell2.13728820
17MP0002138_abnormal_hepatobiliary_system2.06613420
18MP0005025_abnormal_response_to1.97009465
19MP0004859_abnormal_synaptic_plasticity1.96012165
20MP0002419_abnormal_innate_immunity1.94714478
21MP0009785_altered_susceptibility_to1.90823989
22MP0009840_abnormal_foam_cell1.88788559
23MP0002166_altered_tumor_susceptibility1.85120297
24MP0008260_abnormal_autophagy1.82610293
25MP0000604_amyloidosis1.81379328
26MP0000716_abnormal_immune_system1.75874001
27MP0002148_abnormal_hypersensitivity_rea1.75630535
28MP0002398_abnormal_bone_marrow1.75352885
29MP0001873_stomach_inflammation1.74952799
30MP0003191_abnormal_cellular_cholesterol1.67189171
31MP0004947_skin_inflammation1.64769338
32MP0006082_CNS_inflammation1.63445654
33MP0000920_abnormal_myelination1.61677170
34MP0005360_urolithiasis1.58858483
35MP0005464_abnormal_platelet_physiology1.57529767
36MP0005310_abnormal_salivary_gland1.56923285
37MP0008961_abnormal_basal_metabolism1.49707557
38MP0002396_abnormal_hematopoietic_system1.47349749
39MP0000689_abnormal_spleen_morphology1.44300359
40MP0002405_respiratory_system_inflammati1.43558950
41MP0003690_abnormal_glial_cell1.42164577
42MP0003183_abnormal_peptide_metabolism1.41866707
43MP0004381_abnormal_hair_follicle1.41568778
44MP0003329_amyloid_beta_deposits1.41094075
45MP0001845_abnormal_inflammatory_respons1.40636245
46MP0000858_altered_metastatic_potential1.39573317
47MP0010155_abnormal_intestine_physiology1.39219379
48MP0005058_abnormal_lysosome_morphology1.35973578
49MP0002006_tumorigenesis1.32176792
50MP0003828_pulmonary_edema1.30103226
51MP0003866_abnormal_defecation1.29966973
52MP0002139_abnormal_hepatobiliary_system1.29271224
53MP0002429_abnormal_blood_cell1.29170237
54MP0002722_abnormal_immune_system1.28494742
55MP0008569_lethality_at_weaning1.27192888
56MP0004130_abnormal_muscle_cell1.24270681
57MP0001853_heart_inflammation1.19506832
58MP0002132_abnormal_respiratory_system1.16258566
59MP0003075_altered_response_to1.15894703
60MP0002254_reproductive_system_inflammat1.15843216
61MP0008874_decreased_physiological_sensi1.15031500
62MP0008469_abnormal_protein_level1.13232709
63MP0001545_abnormal_hematopoietic_system1.12914722
64MP0005397_hematopoietic_system_phenotyp1.12914722
65MP0003172_abnormal_lysosome_physiology1.12843903
66MP0002009_preneoplasia1.09757900
67MP0000703_abnormal_thymus_morphology1.06930256
68MP0000609_abnormal_liver_physiology1.05778442
69MP0003252_abnormal_bile_duct1.04482968
70MP0010329_abnormal_lipoprotein_level1.03968969
71MP0004883_abnormal_blood_vessel1.03409830
72MP0003045_fibrosis1.02701310
73MP0005365_abnormal_bile_salt0.99749201
74MP0001533_abnormal_skeleton_physiology0.96832133
75MP0005584_abnormal_enzyme/coenzyme_acti0.95520231
76MP0005451_abnormal_body_composition0.95517842
77MP0003635_abnormal_synaptic_transmissio0.95304090
78MP0009764_decreased_sensitivity_to0.95199705
79MP0004808_abnormal_hematopoietic_stem0.94609595
80MP0003633_abnormal_nervous_system0.94116647
81MP0003724_increased_susceptibility_to0.92920906
82MP0002933_joint_inflammation0.92897980
83MP0003646_muscle_fatigue0.92653906
84MP0000569_abnormal_digit_pigmentation0.90566552
85MP0002064_seizures0.88690507
86MP0003656_abnormal_erythrocyte_physiolo0.87751194
87MP0003448_altered_tumor_morphology0.87521545
88MP0000465_gastrointestinal_hemorrhage0.87118648
89MP0002090_abnormal_vision0.85458938
90MP0001663_abnormal_digestive_system0.85192152
91MP0005166_decreased_susceptibility_to0.85053569
92MP0009333_abnormal_splenocyte_physiolog0.84583689
93MP0004185_abnormal_adipocyte_glucose0.84508545
94MP0002909_abnormal_adrenal_gland0.84413794
95MP0001851_eye_inflammation0.80931167
96MP0002118_abnormal_lipid_homeostasis0.80707261
97MP0001502_abnormal_circadian_rhythm0.80409365
98MP0002277_abnormal_respiratory_mucosa0.79944540
99MP0002822_catalepsy0.79798352
100MP0000490_abnormal_crypts_of0.77548387
101MP0005164_abnormal_response_to0.77407830
102MP0009745_abnormal_behavioral_response0.76337381
103MP0005075_abnormal_melanosome_morpholog0.76049854
104MP0009763_increased_sensitivity_to0.76046642
105MP0009278_abnormal_bone_marrow0.74902789
106MP0004036_abnormal_muscle_relaxation0.72155691
107MP0000249_abnormal_blood_vessel0.72047589
108MP0005535_abnormal_body_temperature0.71643724
109MP0009046_muscle_twitch0.71507135
110MP0008004_abnormal_stomach_pH0.70607078
111MP0003091_abnormal_cell_migration0.70580847
112MP0008875_abnormal_xenobiotic_pharmacok0.68851535
113MP0002998_abnormal_bone_remodeling0.68749262
114MP0010234_abnormal_vibrissa_follicle0.67990952
115MP0003453_abnormal_keratinocyte_physiol0.67421450
116MP0005670_abnormal_white_adipose0.66871048
117MP0005390_skeleton_phenotype0.66623880
118MP0005085_abnormal_gallbladder_physiolo0.66026954
119MP0000343_altered_response_to0.64915620
120MP0001348_abnormal_lacrimal_gland0.64002001
121MP0001501_abnormal_sleep_pattern0.62433518
122MP0002019_abnormal_tumor_incidence0.62252505
123MP0005076_abnormal_cell_differentiation0.61988827
124MP0009765_abnormal_xenobiotic_induced0.61760895
125MP0003631_nervous_system_phenotype0.61745720
126MP0002332_abnormal_exercise_endurance0.59479429
127MP0003795_abnormal_bone_structure0.59082182
128MP0003221_abnormal_cardiomyocyte_apopto0.58761185
129MP0001986_abnormal_taste_sensitivity0.53384411
130MP0000015_abnormal_ear_pigmentation0.51753690
131MP0009115_abnormal_fat_cell0.51725699

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)4.36824502
2Colitis (HP:0002583)3.83768587
3Chronic otitis media (HP:0000389)3.83369824
4Recurrent viral infections (HP:0004429)3.72318553
5Elevated erythrocyte sedimentation rate (HP:0003565)3.66177854
6Recurrent bronchitis (HP:0002837)3.56389858
7Cellulitis (HP:0100658)3.47274301
8Inflammation of the large intestine (HP:0002037)3.46497846
9Papilloma (HP:0012740)3.46423193
10Verrucae (HP:0200043)3.46423193
11Recurrent fungal infections (HP:0002841)3.45596625
12Encephalitis (HP:0002383)3.43303483
13T lymphocytopenia (HP:0005403)3.38557378
14Eczematoid dermatitis (HP:0000976)3.36532516
15Gastrointestinal inflammation (HP:0004386)3.33714436
16Recurrent bacterial skin infections (HP:0005406)3.29679290
17Abnormality of T cell number (HP:0011839)3.29025986
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.25772063
19Panhypogammaglobulinemia (HP:0003139)3.22162004
20Keratoconjunctivitis sicca (HP:0001097)3.18327665
21Recurrent abscess formation (HP:0002722)3.12771005
22Gastrointestinal stroma tumor (HP:0100723)3.12269761
23Recurrent cutaneous fungal infections (HP:0011370)3.03600000
24Chronic mucocutaneous candidiasis (HP:0002728)3.03600000
25Vasculitis (HP:0002633)3.01476488
26Meningitis (HP:0001287)2.95102227
27Recurrent skin infections (HP:0001581)2.94160442
28Keratoconjunctivitis (HP:0001096)2.90099139
29Supranuclear gaze palsy (HP:0000605)2.84385324
30Nasal polyposis (HP:0100582)2.83482912
31Recurrent gram-negative bacterial infections (HP:0005420)2.79410031
32Urticaria (HP:0001025)2.79135623
33Prolonged bleeding time (HP:0003010)2.76992793
34Increased IgM level (HP:0003496)2.70907953
35Granulocytopenia (HP:0001913)2.67802595
36Thyroiditis (HP:0100646)2.66763629
37Stomatitis (HP:0010280)2.62460823
38Mitral stenosis (HP:0001718)2.62324052
39Spontaneous hematomas (HP:0007420)2.62146739
40Mediastinal lymphadenopathy (HP:0100721)2.57149944
41Fatigue (HP:0012378)2.54475288
42Recurrent sinusitis (HP:0011108)2.54032522
43Abnormality of the nasal mucosa (HP:0000433)2.53875634
44Loss of speech (HP:0002371)2.51317241
45Autoimmune hemolytic anemia (HP:0001890)2.51013980
46Myositis (HP:0100614)2.49336618
47Epistaxis (HP:0000421)2.47356844
48Increased IgE level (HP:0003212)2.47108350
49Emphysema (HP:0002097)2.44989752
50Papilledema (HP:0001085)2.40637938
51Chronic sinusitis (HP:0011109)2.37573949
52Myocardial infarction (HP:0001658)2.36646539
53Abnormality of T cells (HP:0002843)2.35350505
54Neurofibrillary tangles (HP:0002185)2.34697930
55Abnormality of the fingertips (HP:0001211)2.33403028
56Lymphopenia (HP:0001888)2.32084686
57Autoimmune thrombocytopenia (HP:0001973)2.31699049
58Viral hepatitis (HP:0006562)2.28832315
59Deep venous thrombosis (HP:0002625)2.27679112
60Abnormality of B cell number (HP:0010975)2.26237987
61B lymphocytopenia (HP:0010976)2.26237987
62Onion bulb formation (HP:0003383)2.25898895
63Abnormality of macrophages (HP:0004311)2.25210193
64Pulmonary infiltrates (HP:0002113)2.25172832
65Gangrene (HP:0100758)2.21015299
66Abnormality of cells of the lymphoid lineage (HP:0012140)2.20829459
67Abnormality of the pleura (HP:0002103)2.19362963
68IgM deficiency (HP:0002850)2.17755661
69Gingival bleeding (HP:0000225)2.16731467
70Hypochromic anemia (HP:0001931)2.16031278
71Pulmonary embolism (HP:0002204)2.15902601
72IgG deficiency (HP:0004315)2.15012251
73Optic neuritis (HP:0100653)2.14880406
74Retrobulbar optic neuritis (HP:0100654)2.14880406
75Cerebral hemorrhage (HP:0001342)2.14155592
76Anorexia (HP:0002039)2.13588279
77Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12730510
78Restrictive lung disease (HP:0002091)2.09847418
79Slow saccadic eye movements (HP:0000514)2.07705592
80Episodic fever (HP:0001954)2.06610970
81Severe combined immunodeficiency (HP:0004430)2.04521213
82Hemiplegia (HP:0002301)2.04127389
83Abnormality of eosinophils (HP:0001879)2.03671931
84Skin ulcer (HP:0200042)2.03005483
85Arterial thrombosis (HP:0004420)2.01768977
86Chronic diarrhea (HP:0002028)2.00271610
87Pustule (HP:0200039)1.98081712
88Abnormality of glycolipid metabolism (HP:0010969)1.97911676
89Abnormality of liposaccharide metabolism (HP:0010968)1.97911676
90Abnormality of glycosphingolipid metabolism (HP:0004343)1.97911676
91Glomerulopathy (HP:0100820)1.97111228
92Leukocytosis (HP:0001974)1.96563517
93Osteomyelitis (HP:0002754)1.96107328
94Recurrent pneumonia (HP:0006532)1.94870791
95Hematochezia (HP:0002573)1.93899761
96Interstitial pulmonary disease (HP:0006530)1.93664341
97Gingivitis (HP:0000230)1.93273554
98Increased cerebral lipofuscin (HP:0011813)1.92854453
99Gastrointestinal infarctions (HP:0005244)1.92689332
100Chest pain (HP:0100749)1.91900391
101Complement deficiency (HP:0004431)1.91722273
102Abnormality of the peritoneum (HP:0002585)1.91537607
103Combined immunodeficiency (HP:0005387)1.91494153
104Purpura (HP:0000979)1.89819441
105Eosinophilia (HP:0001880)1.89615297
106Cerebral inclusion bodies (HP:0100314)1.89288928
107Sepsis (HP:0100806)1.88711253
108Orchitis (HP:0100796)1.88674510
109Arthralgia (HP:0002829)1.88559692
110Axonal loss (HP:0003447)1.87830635
111IgA deficiency (HP:0002720)1.86325288
112Hemoptysis (HP:0002105)1.86045654
113Polycythemia (HP:0001901)1.84915565
114Exercise-induced myalgia (HP:0003738)1.84748398
115Dysmetria (HP:0001310)1.82496718
116Bronchitis (HP:0012387)1.81142499
117Joint swelling (HP:0001386)1.78451381
118Hypergammaglobulinemia (HP:0010702)1.77608416
119Dysmetric saccades (HP:0000641)1.77079225
120Peripheral hypomyelination (HP:0007182)1.76138875
121Obstructive lung disease (HP:0006536)1.75492624
122Chronic obstructive pulmonary disease (HP:0006510)1.75492624
123Xanthomatosis (HP:0000991)1.75077816
124Periodontitis (HP:0000704)1.74262940
125Dysostosis multiplex (HP:0000943)1.73042955
126Abnormality of T cell physiology (HP:0011840)1.72878737
127Systemic lupus erythematosus (HP:0002725)1.71934218
128Abnormality of aromatic amino acid family metabolism (HP:0004338)1.71110230

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.17977803
2MAP3K132.99302084
3MAP3K102.81545868
4TYK22.55345613
5GRK62.43389062
6MAP3K142.35235793
7EPHB12.20059849
8JAK12.18867184
9RIPK42.00539468
10TBK11.87267624
11FGFR41.86902639
12FES1.85212976
13JAK31.84648114
14IKBKE1.77961048
15ITK1.77187383
16SIK21.75770728
17SYK1.63859057
18SIK31.59551318
19TRIB31.54481175
20EEF2K1.51943310
21ERN11.49373215
22TXK1.48817328
23PRKCH1.43116898
24BLK1.40989057
25HCK1.40415777
26MAP3K71.37974823
27KSR21.37855977
28ZAP701.34412739
29BTK1.33682269
30PKN21.27369450
31FGFR31.26425638
32CSF1R1.26418391
33STK101.24630562
34MAP3K31.22800847
35IKBKB1.21287485
36PKN11.18170812
37CSK1.17561549
38RIPK11.16918175
39JAK21.14234255
40LCK1.12443073
41PRKCQ1.05410956
42PDK11.04028917
43CDK121.01663990
44KIT1.01576616
45CDC42BPA1.01351109
46BMPR21.01258276
47MAP3K91.00700995
48SMG10.98964916
49IRAK40.98614833
50MARK30.98199993
51FGFR20.95671591
52SIK10.94742708
53LRRK20.93984991
54TAOK30.92259515
55TTN0.92176459
56PAK60.91339079
57PTK60.88050170
58TAOK20.87330422
59HIPK20.86380333
60MARK20.85121819
61MAPK120.84488772
62STK110.83807052
63CLK10.81585379
64NLK0.80004076
65IRAK10.78349477
66TAOK10.78318283
67PRKD20.76652542
68CAMKK20.75670255
69WNK10.74674780
70MAP3K10.74549925
71YES10.74323216
72RET0.73775853
73CHUK0.73605238
74SGK30.73034857
75PDPK10.72581503
76MATK0.72159589
77PRKD10.70606572
78EPHA30.67725765
79TGFBR20.66958727
80TEC0.66489672
81IRAK20.66328312
82MAPK110.66086853
83CAMK1G0.64574290
84CDK40.64477636
85CAMKK10.64377028
86DAPK20.63837632
87LYN0.63034364
88TNK20.61784386
89PASK0.59402084
90TYRO30.58277111
91FGR0.57838290
92PHKG20.55770995
93PHKG10.55770995
94DMPK0.55509243
95* FYN0.54437782
96SGK2230.54400424
97SGK4940.54400424
98PDGFRB0.52713980
99ALK0.52572009
100DYRK1B0.52075722
101LMTK20.51055513
102PRKAA20.49768600
103IRAK30.48592189
104CDK60.48131292
105PRPF4B0.46789558
106MELK0.46697697
107MAP2K30.45310648
108MAPK70.43955588
109SGK20.43865884
110GRK70.43828872
111MAP3K110.43726263
112CDK50.43237121
113PIM10.42123904
114BRD40.41613699
115TESK20.41497242
116CAMK1D0.40955626
117RPS6KL10.40261264
118RPS6KC10.40261264
119EPHA40.38465076
120RAF10.38106044
121MAP3K20.37771921
122SGK10.35796522
123ICK0.35505955
124CAMK40.35277985
125NTRK10.35137466
126MAP3K60.32207847
127MAPK40.32199031

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.91707441
2B cell receptor signaling pathway_Homo sapiens_hsa046622.72265849
3Autoimmune thyroid disease_Homo sapiens_hsa053202.60267350
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.36130028
5Nitrogen metabolism_Homo sapiens_hsa009102.17421444
6Type I diabetes mellitus_Homo sapiens_hsa049402.03278912
7Osteoclast differentiation_Homo sapiens_hsa043802.02591132
8T cell receptor signaling pathway_Homo sapiens_hsa046601.83140000
9Asthma_Homo sapiens_hsa053101.76321712
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.73492618
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.71550547
12Leishmaniasis_Homo sapiens_hsa051401.59908105
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.54368404
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.54320756
15Staphylococcus aureus infection_Homo sapiens_hsa051501.52999235
16Herpes simplex infection_Homo sapiens_hsa051681.49066183
17Chemokine signaling pathway_Homo sapiens_hsa040621.48590675
18Other glycan degradation_Homo sapiens_hsa005111.47419272
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35152352
20Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30010714
21Type II diabetes mellitus_Homo sapiens_hsa049301.29812897
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29479395
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28437207
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24643193
25Measles_Homo sapiens_hsa051621.18904073
26Arginine biosynthesis_Homo sapiens_hsa002201.11753158
27Rheumatoid arthritis_Homo sapiens_hsa053231.10503071
28Legionellosis_Homo sapiens_hsa051341.05075452
29Adipocytokine signaling pathway_Homo sapiens_hsa049201.03196649
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02840646
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01784079
32Tuberculosis_Homo sapiens_hsa051520.99720878
33Toxoplasmosis_Homo sapiens_hsa051450.98924749
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98290542
35Dorso-ventral axis formation_Homo sapiens_hsa043200.98098028
36Phagosome_Homo sapiens_hsa041450.96829712
37Primary bile acid biosynthesis_Homo sapiens_hsa001200.96755887
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96006432
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95808529
40Insulin resistance_Homo sapiens_hsa049310.95609949
41Jak-STAT signaling pathway_Homo sapiens_hsa046300.94099126
42Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93713280
43TNF signaling pathway_Homo sapiens_hsa046680.93493788
44Morphine addiction_Homo sapiens_hsa050320.92808661
45NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91753967
46Epstein-Barr virus infection_Homo sapiens_hsa051690.89629155
47Acute myeloid leukemia_Homo sapiens_hsa052210.88794778
48Inositol phosphate metabolism_Homo sapiens_hsa005620.88095598
49Neurotrophin signaling pathway_Homo sapiens_hsa047220.88038185
50Allograft rejection_Homo sapiens_hsa053300.86985035
51Hematopoietic cell lineage_Homo sapiens_hsa046400.86614772
52ABC transporters_Homo sapiens_hsa020100.85457515
53Olfactory transduction_Homo sapiens_hsa047400.83730927
54Platelet activation_Homo sapiens_hsa046110.83722920
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83462135
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83390250
57VEGF signaling pathway_Homo sapiens_hsa043700.81963339
58Salivary secretion_Homo sapiens_hsa049700.81588106
59Chronic myeloid leukemia_Homo sapiens_hsa052200.79984044
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.79895153
61* Phospholipase D signaling pathway_Homo sapiens_hsa040720.78947439
62Gastric acid secretion_Homo sapiens_hsa049710.78269130
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77841367
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76619671
65Glutamatergic synapse_Homo sapiens_hsa047240.76096451
66Circadian entrainment_Homo sapiens_hsa047130.75619486
67HTLV-I infection_Homo sapiens_hsa051660.75011337
68Prolactin signaling pathway_Homo sapiens_hsa049170.74559782
69Graft-versus-host disease_Homo sapiens_hsa053320.74281658
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73755031
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73655046
72Complement and coagulation cascades_Homo sapiens_hsa046100.72448092
73Long-term potentiation_Homo sapiens_hsa047200.72244459
74Endometrial cancer_Homo sapiens_hsa052130.71890950
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71778114
76Pertussis_Homo sapiens_hsa051330.71651786
77Pancreatic cancer_Homo sapiens_hsa052120.71582400
78Non-small cell lung cancer_Homo sapiens_hsa052230.71140934
79Renal cell carcinoma_Homo sapiens_hsa052110.71043017
80Renin secretion_Homo sapiens_hsa049240.70967124
81Viral carcinogenesis_Homo sapiens_hsa052030.70591081
82Cholinergic synapse_Homo sapiens_hsa047250.70460329
83FoxO signaling pathway_Homo sapiens_hsa040680.70096833
84* Endocytosis_Homo sapiens_hsa041440.69824665
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68879076
86Oxytocin signaling pathway_Homo sapiens_hsa049210.68632883
87Bile secretion_Homo sapiens_hsa049760.68258504
88Colorectal cancer_Homo sapiens_hsa052100.68016563
89GABAergic synapse_Homo sapiens_hsa047270.67262675
90MAPK signaling pathway_Homo sapiens_hsa040100.66681893
91Caffeine metabolism_Homo sapiens_hsa002320.66055194
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65848843
93PPAR signaling pathway_Homo sapiens_hsa033200.65798636
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65039409
95Influenza A_Homo sapiens_hsa051640.64843354
96Notch signaling pathway_Homo sapiens_hsa043300.63808102
97Antigen processing and presentation_Homo sapiens_hsa046120.62908736
98Hepatitis B_Homo sapiens_hsa051610.62411596
99Salmonella infection_Homo sapiens_hsa051320.60213813
100Choline metabolism in cancer_Homo sapiens_hsa052310.59230161
101Viral myocarditis_Homo sapiens_hsa054160.58515436
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57990459
103Shigellosis_Homo sapiens_hsa051310.56598507
104GnRH signaling pathway_Homo sapiens_hsa049120.56502826
105Apoptosis_Homo sapiens_hsa042100.55485592
106mTOR signaling pathway_Homo sapiens_hsa041500.54577355
107Insulin secretion_Homo sapiens_hsa049110.54432890
108Malaria_Homo sapiens_hsa051440.54362574
109Fatty acid degradation_Homo sapiens_hsa000710.54127452
110cAMP signaling pathway_Homo sapiens_hsa040240.54119115
111ErbB signaling pathway_Homo sapiens_hsa040120.53538086
112Glioma_Homo sapiens_hsa052140.53482571
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.53402496
114Hepatitis C_Homo sapiens_hsa051600.53193373
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53018187
116HIF-1 signaling pathway_Homo sapiens_hsa040660.52928222
117African trypanosomiasis_Homo sapiens_hsa051430.52394630
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51026045
119Prostate cancer_Homo sapiens_hsa052150.50937441
120Lysosome_Homo sapiens_hsa041420.50145363
121Synaptic vesicle cycle_Homo sapiens_hsa047210.49322982
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49186688
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49109900
124Lysine degradation_Homo sapiens_hsa003100.47371948
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45376206
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.44967258
127Amoebiasis_Homo sapiens_hsa051460.43173576
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42230727
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41750943
130Estrogen signaling pathway_Homo sapiens_hsa049150.34351252
131Insulin signaling pathway_Homo sapiens_hsa049100.33239197
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.32618111
133Rap1 signaling pathway_Homo sapiens_hsa040150.32432087

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