CYSLTR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.01761244
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.01761244
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.01761244
4modulation by symbiont of host immune response (GO:0052553)6.01761244
5positive regulation by symbiont of host defense response (GO:0052509)6.01761244
6modulation by symbiont of host defense response (GO:0052031)6.01761244
7neutrophil activation involved in immune response (GO:0002283)5.87965343
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.73098503
9microglial cell activation (GO:0001774)5.26824734
10regulation of B cell receptor signaling pathway (GO:0050855)5.18980478
11tryptophan catabolic process (GO:0006569)4.98470037
12indole-containing compound catabolic process (GO:0042436)4.98470037
13indolalkylamine catabolic process (GO:0046218)4.98470037
14kynurenine metabolic process (GO:0070189)4.87417300
15macrophage activation involved in immune response (GO:0002281)4.81069815
16behavioral response to nicotine (GO:0035095)4.76510773
17positive regulation of monocyte chemotaxis (GO:0090026)4.61335161
18indolalkylamine metabolic process (GO:0006586)4.44508269
19regulation of interferon-beta biosynthetic process (GO:0045357)4.41603290
20response to peptidoglycan (GO:0032494)4.30761148
21tryptophan metabolic process (GO:0006568)4.29732345
22macrophage activation (GO:0042116)4.29054480
23positive regulation of antigen processing and presentation (GO:0002579)4.27311487
24fucose catabolic process (GO:0019317)4.16426472
25L-fucose metabolic process (GO:0042354)4.16426472
26L-fucose catabolic process (GO:0042355)4.16426472
27respiratory burst (GO:0045730)4.16046340
28response to host immune response (GO:0052572)4.14452515
29response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.14452515
30positive regulation of cellular amide metabolic process (GO:0034250)4.13511617
31neutrophil activation (GO:0042119)4.12106839
32regulation of establishment of cell polarity (GO:2000114)4.10336340
33immunoglobulin mediated immune response (GO:0016064)4.07171698
34interkinetic nuclear migration (GO:0022027)4.06610501
35positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.06440198
36positive regulation of developmental pigmentation (GO:0048087)4.05672532
37myeloid cell activation involved in immune response (GO:0002275)4.04905621
38granulocyte activation (GO:0036230)4.04822150
39regulation of pigment cell differentiation (GO:0050932)3.98118609
40regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.97690948
41neural tube formation (GO:0001841)3.97224944
42production of molecular mediator involved in inflammatory response (GO:0002532)3.94361274
43regulation of interferon-alpha production (GO:0032647)3.94020582
44cellular extravasation (GO:0045123)3.90648462
45pinocytosis (GO:0006907)3.88595711
46indole-containing compound metabolic process (GO:0042430)3.85565292
47positive regulation of interferon-alpha production (GO:0032727)3.80843614
48serotonin metabolic process (GO:0042428)3.76043734
49T cell migration (GO:0072678)3.73259998
50regulation of antigen processing and presentation (GO:0002577)3.73059755
51snRNA transcription (GO:0009301)3.72749172
52sulfation (GO:0051923)3.70612962
53regulation of hippo signaling (GO:0035330)3.70208591
54regulation of monocyte chemotaxis (GO:0090025)3.69676885
55positive regulation of macrophage differentiation (GO:0045651)3.68675410
56response to host (GO:0075136)3.68096631
57response to host defenses (GO:0052200)3.68096631
58response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.68096631
59tolerance induction (GO:0002507)3.68011323
60protein K48-linked deubiquitination (GO:0071108)3.67648167
61eosinophil chemotaxis (GO:0048245)3.64648527
62negative regulation of mast cell activation (GO:0033004)3.63914069
63regulation of establishment or maintenance of cell polarity (GO:0032878)3.63404158
64negative regulation of sodium ion transport (GO:0010766)3.56051312
65primary amino compound metabolic process (GO:1901160)3.55647142
66regulation of dendritic cell antigen processing and presentation (GO:0002604)3.55466046
67neuronal action potential (GO:0019228)3.52857551
68positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.50712521
69positive regulation of lymphocyte migration (GO:2000403)3.49336534
70oxidative demethylation (GO:0070989)3.45379068
71positive regulation of mast cell activation (GO:0033005)3.44778074
72negative regulation of translation, ncRNA-mediated (GO:0040033)3.43268330
73regulation of translation, ncRNA-mediated (GO:0045974)3.43268330
74negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.43268330
75regulation of mast cell activation (GO:0033003)3.42196086
76endosome to melanosome transport (GO:0035646)3.41450640
77endosome to pigment granule transport (GO:0043485)3.41450640
78regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.41147723
79superoxide anion generation (GO:0042554)3.40712029
80regulation of posttranscriptional gene silencing (GO:0060147)3.40010231
81regulation of gene silencing by miRNA (GO:0060964)3.40010231
82regulation of gene silencing by RNA (GO:0060966)3.40010231
83monocyte chemotaxis (GO:0002548)3.39679164
84epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.37530589
85signal peptide processing (GO:0006465)3.36453507
86detection of light stimulus involved in visual perception (GO:0050908)3.35234580
87detection of light stimulus involved in sensory perception (GO:0050962)3.35234580
88regulation of mast cell degranulation (GO:0043304)3.34369408
89flavonoid metabolic process (GO:0009812)3.33465852
90cellular ketone body metabolic process (GO:0046950)3.32970142
91phagocytosis, engulfment (GO:0006911)3.30661089
92mast cell activation (GO:0045576)3.29219493
93gamma-aminobutyric acid transport (GO:0015812)3.29041118
94regulation of mononuclear cell migration (GO:0071675)3.28346990
95positive regulation of T cell migration (GO:2000406)3.26237255
96myeloid leukocyte activation (GO:0002274)3.25734558
97establishment of protein localization to Golgi (GO:0072600)3.25211737
98lymphocyte chemotaxis (GO:0048247)3.25019782
99monoubiquitinated protein deubiquitination (GO:0035520)3.24288843
100cellular response to exogenous dsRNA (GO:0071360)3.23895043
101eosinophil migration (GO:0072677)3.21462767
102detection of molecule of bacterial origin (GO:0032490)3.20231252
103positive regulation of chemokine secretion (GO:0090197)3.20027820
104lipopolysaccharide-mediated signaling pathway (GO:0031663)3.19901103
105positive regulation of mast cell degranulation (GO:0043306)3.18419922
106positive regulation of mast cell activation involved in immune response (GO:0033008)3.18419922
107regulation of lymphocyte migration (GO:2000401)3.17791865
108negative regulation of systemic arterial blood pressure (GO:0003085)3.14000769
109negative regulation of B cell proliferation (GO:0030889)3.13465895
110positive regulation of T-helper 1 type immune response (GO:0002827)3.13365785
111NAD biosynthetic process (GO:0009435)3.12550293
112regulation of mast cell activation involved in immune response (GO:0033006)3.12503703
113reflex (GO:0060004)3.11207219
114positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.11182594
115regulation of lymphocyte chemotaxis (GO:1901623)3.09263741
116cardiovascular system development (GO:0072358)3.09157475
117lipoxygenase pathway (GO:0019372)3.07285744
118cilium or flagellum-dependent cell motility (GO:0001539)3.05212369
119dendritic cell migration (GO:0036336)3.05126203
120detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.05086592
121protein K63-linked deubiquitination (GO:0070536)3.03860077
122protein K11-linked deubiquitination (GO:0035871)3.03563277
123negative regulation of granulocyte differentiation (GO:0030853)3.03533510
124negative regulation of interleukin-12 production (GO:0032695)3.02387374
125I-kappaB phosphorylation (GO:0007252)3.02183176
126regulation of MHC class II biosynthetic process (GO:0045346)3.01962306
127positive regulation of gamma-delta T cell activation (GO:0046645)3.01670811
128regulation of interleukin-8 biosynthetic process (GO:0045414)3.01232356
129positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.00000620
130defense response to protozoan (GO:0042832)2.99984794
131regulation of myeloid leukocyte mediated immunity (GO:0002886)2.98575120
132dendritic cell chemotaxis (GO:0002407)2.95723553
133response to muramyl dipeptide (GO:0032495)2.95510700
134positive regulation of tumor necrosis factor production (GO:0032760)2.95178013
135B cell mediated immunity (GO:0019724)2.94256412
136ketone body metabolic process (GO:1902224)2.93595161
137cytoplasmic mRNA processing body assembly (GO:0033962)2.91750554
138negative regulation of cell killing (GO:0031342)2.90558262
139negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.90558262
140germinal center formation (GO:0002467)2.89681103
141positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.89507930
142interferon-gamma production (GO:0032609)2.89339235
143glycosphingolipid catabolic process (GO:0046479)2.89178884
144regulation of leukocyte degranulation (GO:0043300)2.87809586
145negative regulation of cytosolic calcium ion concentration (GO:0051481)2.86537368
146T-helper 1 type immune response (GO:0042088)2.85689880
147regulation of T cell migration (GO:2000404)2.84756465
148positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.84332325
149amine catabolic process (GO:0009310)2.83482197
150cellular biogenic amine catabolic process (GO:0042402)2.83482197
151interferon-gamma-mediated signaling pathway (GO:0060333)2.82655082
152thyroid hormone metabolic process (GO:0042403)2.82185194
153leukocyte degranulation (GO:0043299)2.81033695
154myeloid dendritic cell activation (GO:0001773)2.80455340
155behavioral response to ethanol (GO:0048149)2.80243892
156leukocyte aggregation (GO:0070486)2.78749408
157negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.77725389
158Arp2/3 complex-mediated actin nucleation (GO:0034314)2.75672687
159lipid translocation (GO:0034204)2.75385809
160phospholipid translocation (GO:0045332)2.75385809
161pericardium development (GO:0060039)2.74530156
162phosphatidylinositol acyl-chain remodeling (GO:0036149)2.72070210
163negative regulation of protein localization to cell surface (GO:2000009)2.70524749
164membrane depolarization during action potential (GO:0086010)2.69237479
165regulation of action potential (GO:0098900)2.67860936
166cellular response to ethanol (GO:0071361)2.67210648
167protein targeting to vacuole (GO:0006623)2.66956794
168protein targeting to lysosome (GO:0006622)2.66956794
169establishment of protein localization to vacuole (GO:0072666)2.66956794
170benzene-containing compound metabolic process (GO:0042537)2.64945526
171cAMP catabolic process (GO:0006198)2.63554568
172cellular response to ATP (GO:0071318)2.61385912
173cornea development in camera-type eye (GO:0061303)2.61189797
174kidney morphogenesis (GO:0060993)2.57285283
175rRNA catabolic process (GO:0016075)2.56625441
176negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.54569545
177piRNA metabolic process (GO:0034587)2.53647469
178photoreceptor cell maintenance (GO:0045494)2.53472417
179spinal cord motor neuron differentiation (GO:0021522)2.52346032
180cell morphogenesis involved in neuron differentiation (GO:0048667)2.51924023
181aromatic amino acid family catabolic process (GO:0009074)2.47955028
182regulation of mesoderm development (GO:2000380)2.47280696
183negative regulation of synaptic transmission, GABAergic (GO:0032229)2.45199026
184endocardial cushion development (GO:0003197)2.45149141
185positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.44923110
186regulation of short-term neuronal synaptic plasticity (GO:0048172)2.44813268
187positive regulation of CREB transcription factor activity (GO:0032793)2.44714320
188endoderm formation (GO:0001706)2.41439380
189RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.40358764
190membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.40109669
191cilium organization (GO:0044782)2.38536707
192purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.37963138
1933-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.37963138
194proline transport (GO:0015824)2.37608017
195DNA demethylation (GO:0080111)2.37462470
196cyclic nucleotide catabolic process (GO:0009214)2.36731246
197DNA deamination (GO:0045006)2.36278195
198positive regulation of action potential (GO:0045760)2.36132245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.57513926
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.71599599
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.20214512
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.73395110
5IRF8_27001747_Chip-Seq_BMDM_Mouse4.69302307
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.39615088
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.66585171
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.51714763
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.50544091
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.46732207
11GBX2_23144817_ChIP-Seq_PC3_Human3.41689356
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.33742543
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.32503232
14ZNF274_21170338_ChIP-Seq_K562_Hela3.23945180
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.17861235
16VDR_22108803_ChIP-Seq_LS180_Human3.02120830
17EZH2_22144423_ChIP-Seq_EOC_Human2.69609402
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.63761273
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.58915905
20* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.49643661
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.39738015
22TAF15_26573619_Chip-Seq_HEK293_Human2.31980003
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.28561097
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26129655
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22077583
26RUNX_20019798_ChIP-Seq_JUKART_Human2.20148399
27PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse2.06372727
28EWS_26573619_Chip-Seq_HEK293_Human2.06002367
29IGF1R_20145208_ChIP-Seq_DFB_Human2.05939551
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.04901372
31SPI1_23547873_ChIP-Seq_NB4_Human2.04410908
32PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.03909282
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.00788892
34ER_23166858_ChIP-Seq_MCF-7_Human2.00700031
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.99627486
36VDR_24787735_ChIP-Seq_THP-1_Human1.99527801
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.96953572
38* P300_19829295_ChIP-Seq_ESCs_Human1.93605565
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.92563266
40FUS_26573619_Chip-Seq_HEK293_Human1.90984776
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90374045
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88854799
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86455470
44STAT3_23295773_ChIP-Seq_U87_Human1.85693023
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.83931883
46SCL_19346495_ChIP-Seq_HPC-7_Human1.82574918
47PU_27001747_Chip-Seq_BMDM_Mouse1.78671648
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78171806
49MYB_26560356_Chip-Seq_TH2_Human1.75103213
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71830313
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71574224
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69492104
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.68930528
54CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.66874331
55AR_21572438_ChIP-Seq_LNCaP_Human1.65826669
56* SMAD4_21799915_ChIP-Seq_A2780_Human1.64612398
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.64520695
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63195266
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62930061
60SPI1_23127762_ChIP-Seq_K562_Human1.58812291
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58244318
62* TCF4_23295773_ChIP-Seq_U87_Human1.58234981
63TP53_16413492_ChIP-PET_HCT116_Human1.57013910
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.55712593
65AR_25329375_ChIP-Seq_VCAP_Human1.54795877
66BCAT_22108803_ChIP-Seq_LS180_Human1.53062933
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53042707
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51606968
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51606968
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50299960
71RUNX1_22412390_ChIP-Seq_EML_Mouse1.48878594
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48117936
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46931182
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46889816
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.45075502
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43977144
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43326476
78CBP_20019798_ChIP-Seq_JUKART_Human1.38844182
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38844182
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.38816391
81CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38763994
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36947954
83VDR_24763502_ChIP-Seq_THP-1_Human1.36789451
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33067379
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31875601
86TCF4_22108803_ChIP-Seq_LS180_Human1.31825273
87* RUNX2_22187159_ChIP-Seq_PCA_Human1.31272508
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31092709
89DROSHA_22980978_ChIP-Seq_HELA_Human1.29914429
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29839106
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29049374
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.28003684
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27250189
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26771882
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.26049660
96CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26029261
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25487489
98MYB_26560356_Chip-Seq_TH1_Human1.25219870
99AHR_22903824_ChIP-Seq_MCF-7_Human1.24385530
100CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23563595
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22705904
102EGR1_19374776_ChIP-ChIP_THP-1_Human1.21720862
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21070410
104EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20359938
105SMAD4_21741376_ChIP-Seq_EPCs_Human1.20033635
106REST_21632747_ChIP-Seq_MESCs_Mouse1.19436511
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19144560
108MAF_26560356_Chip-Seq_TH1_Human1.17459234
109ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16515858
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13813632
111FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13551754
112NANOG_19829295_ChIP-Seq_ESCs_Human1.13027351
113SOX2_19829295_ChIP-Seq_ESCs_Human1.13027351
114IRF1_19129219_ChIP-ChIP_H3396_Human1.12364282
115NOTCH1_21737748_ChIP-Seq_TLL_Human1.12192249
116GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12130831
117NANOG_18555785_Chip-Seq_ESCs_Mouse1.11783700
118SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11602670
119KDM2B_26808549_Chip-Seq_REH_Human1.09661425
120FOXA1_25329375_ChIP-Seq_VCAP_Human1.08955040
121FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08955040
122CRX_20693478_ChIP-Seq_RETINA_Mouse1.08531446
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08427366
124ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08013177
125FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07419707
126FLI1_27457419_Chip-Seq_LIVER_Mouse1.07335003
127CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07061948
128SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06983057
129RXR_22108803_ChIP-Seq_LS180_Human1.06895792
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05869328
131SOX2_21211035_ChIP-Seq_LN229_Gbm1.05708969
132KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05655268
133TP53_22573176_ChIP-Seq_HFKS_Human1.05642909
134TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05468821
135FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03480470
136BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03278000
137CBX2_27304074_Chip-Seq_ESCs_Mouse1.03184214
138FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03124181
139GATA3_26560356_Chip-Seq_TH2_Human1.02526939
140PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01651467
141CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01431904
142ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99900618
143RNF2_27304074_Chip-Seq_NSC_Mouse0.99327788
144PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98787366
145OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98452679
146CDX2_22108803_ChIP-Seq_LS180_Human0.98427273
147CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97915582
148MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97314934
149NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96956610
150RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92408231
151GATA3_27048872_Chip-Seq_THYMUS_Human0.91020060
152GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85911009
153CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84321750
154GATA1_22025678_ChIP-Seq_K562_Human0.83149511
155PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83031400
156FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83007229
157CJUN_26792858_Chip-Seq_BT549_Human0.82792628
158SUZ12_27294783_Chip-Seq_NPCs_Mouse0.81404941
159EZH2_27294783_Chip-Seq_NPCs_Mouse0.80725370
160VDR_21846776_ChIP-Seq_THP-1_Human0.79892984
161PU1_27457419_Chip-Seq_LIVER_Mouse0.78508305
162SUZ12_18555785_Chip-Seq_ESCs_Mouse0.78481419
163PCGF2_27294783_Chip-Seq_NPCs_Mouse0.76604050
164NFE2_27457419_Chip-Seq_LIVER_Mouse0.76059393
165E2F1_18555785_Chip-Seq_ESCs_Mouse0.75258218
166E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.75030050
167STAT3_18555785_Chip-Seq_ESCs_Mouse0.73216791
168* EGR1_19032775_ChIP-ChIP_M12_Human0.72463830
169P53_22387025_ChIP-Seq_ESCs_Mouse0.72255891
170SMRT_27268052_Chip-Seq_Bcells_Human0.70959466
171NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.69779359
172NRF2_20460467_ChIP-Seq_MEFs_Mouse0.69779359
173CMYC_18555785_Chip-Seq_ESCs_Mouse0.69763630
174PRDM14_20953172_ChIP-Seq_ESCs_Human0.69673356
175CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69328536
176CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.68967820
177P300_18555785_Chip-Seq_ESCs_Mouse0.68712520
178NMYC_18555785_Chip-Seq_ESCs_Mouse0.68353553
179POU3F2_20337985_ChIP-ChIP_501MEL_Human0.67817871
180TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.66376013
181RUNX1_27457419_Chip-Seq_LIVER_Mouse0.66347315
182EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.65871099
183UTX_26944678_Chip-Seq_JUKART_Human0.65866094

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.13375392
2MP0003436_decreased_susceptibility_to3.88551449
3MP0003195_calcinosis3.82057735
4* MP0002148_abnormal_hypersensitivity_rea3.70416625
5MP0006082_CNS_inflammation3.53162787
6MP0003303_peritoneal_inflammation3.38164317
7MP0002419_abnormal_innate_immunity3.36032659
8MP0005000_abnormal_immune_tolerance3.26823510
9MP0009785_altered_susceptibility_to3.22820991
10MP0003646_muscle_fatigue3.20100593
11MP0005671_abnormal_response_to3.17298408
12MP0001790_abnormal_immune_system3.03142677
13MP0005387_immune_system_phenotype3.03142677
14MP0005025_abnormal_response_to2.92342306
15MP0003724_increased_susceptibility_to2.87993749
16MP0002452_abnormal_antigen_presenting2.81436667
17MP0008057_abnormal_DNA_replication2.79220650
18MP0009046_muscle_twitch2.75150032
19MP0005058_abnormal_lysosome_morphology2.74086477
20MP0001800_abnormal_humoral_immune2.65557175
21MP0004043_abnormal_pH_regulation2.61281661
22MP0002723_abnormal_immune_serum2.58029014
23MP0003172_abnormal_lysosome_physiology2.55957202
24MP0008877_abnormal_DNA_methylation2.51299396
25MP0005551_abnormal_eye_electrophysiolog2.46184315
26MP0004510_myositis2.43861093
27MP0000685_abnormal_immune_system2.42308624
28MP0001819_abnormal_immune_cell2.38852943
29MP0002420_abnormal_adaptive_immunity2.36541065
30MP0000427_abnormal_hair_cycle2.32638416
31MP0001968_abnormal_touch/_nociception2.30621492
32MP0001501_abnormal_sleep_pattern2.26772948
33MP0005464_abnormal_platelet_physiology2.16194562
34MP0001533_abnormal_skeleton_physiology2.06359347
35MP0000343_altered_response_to2.05234934
36MP0002837_dystrophic_cardiac_calcinosis2.04536143
37MP0008961_abnormal_basal_metabolism2.04117417
38MP0009745_abnormal_behavioral_response2.02441307
39MP0005310_abnormal_salivary_gland1.95038070
40MP0002102_abnormal_ear_morphology1.91422093
41MP0004142_abnormal_muscle_tone1.91346904
42MP0003787_abnormal_imprinting1.88588518
43* MP0002405_respiratory_system_inflammati1.87118768
44MP0002736_abnormal_nociception_after1.84740480
45MP0001845_abnormal_inflammatory_respons1.82801331
46MP0003690_abnormal_glial_cell1.82795421
47MP0001853_heart_inflammation1.79924142
48MP0008872_abnormal_physiological_respon1.72638139
49MP0003890_abnormal_embryonic-extraembry1.71461579
50MP0000383_abnormal_hair_follicle1.70987304
51MP0003075_altered_response_to1.70144283
52MP0010155_abnormal_intestine_physiology1.68163557
53MP0004130_abnormal_muscle_cell1.67920574
54MP0009764_decreased_sensitivity_to1.66804138
55MP0003136_yellow_coat_color1.65470628
56MP0009333_abnormal_splenocyte_physiolog1.64860222
57MP0000716_abnormal_immune_system1.62822423
58MP0002998_abnormal_bone_remodeling1.62379207
59MP0005645_abnormal_hypothalamus_physiol1.59947309
60MP0003183_abnormal_peptide_metabolism1.59459029
61MP0005646_abnormal_pituitary_gland1.57026936
62MP0010386_abnormal_urinary_bladder1.57001917
63MP0000569_abnormal_digit_pigmentation1.56586034
64MP0008469_abnormal_protein_level1.56381159
65MP0002272_abnormal_nervous_system1.56075246
66MP0002277_abnormal_respiratory_mucosa1.55618726
67MP0003191_abnormal_cellular_cholesterol1.54946244
68MP0002876_abnormal_thyroid_physiology1.54843147
69MP0003448_altered_tumor_morphology1.53545245
70MP0002064_seizures1.51877015
71MP0003300_gastrointestinal_ulcer1.51063849
72MP0001486_abnormal_startle_reflex1.48259624
73MP0005253_abnormal_eye_physiology1.47234428
74MP0002735_abnormal_chemical_nociception1.46772564
75MP0002398_abnormal_bone_marrow1.46508984
76MP0001986_abnormal_taste_sensitivity1.44010149
77MP0001485_abnormal_pinna_reflex1.42958844
78MP0004924_abnormal_behavior1.40881367
79MP0005386_behavior/neurological_phenoty1.40881367
80MP0005174_abnormal_tail_pigmentation1.39684270
81MP0008875_abnormal_xenobiotic_pharmacok1.39574219
82MP0002006_tumorigenesis1.35819106
83MP0002166_altered_tumor_susceptibility1.35317475
84MP0004145_abnormal_muscle_electrophysio1.32306047
85MP0005166_decreased_susceptibility_to1.32170345
86MP0006072_abnormal_retinal_apoptosis1.30950980
87MP0002733_abnormal_thermal_nociception1.28945309
88MP0002572_abnormal_emotion/affect_behav1.28186446
89MP0000015_abnormal_ear_pigmentation1.27641054
90MP0002067_abnormal_sensory_capabilities1.27354627
91MP0000689_abnormal_spleen_morphology1.26567771
92MP0002429_abnormal_blood_cell1.25173145
93MP0001970_abnormal_pain_threshold1.24978158
94MP0000465_gastrointestinal_hemorrhage1.24827874
95MP0003828_pulmonary_edema1.24580789
96MP0004947_skin_inflammation1.24250630
97MP0003252_abnormal_bile_duct1.23245239
98MP0002933_joint_inflammation1.22243008
99MP0004147_increased_porphyrin_level1.22065681
100MP0004133_heterotaxia1.21434772
101MP0000631_abnormal_neuroendocrine_gland1.21213531
102MP0005266_abnormal_metabolism1.18705881
103MP0000230_abnormal_systemic_arterial1.16436514
104MP0002396_abnormal_hematopoietic_system1.16023398
105MP0002138_abnormal_hepatobiliary_system1.14017674
106MP0002722_abnormal_immune_system1.13082949
107MP0002653_abnormal_ependyma_morphology1.11501301
108MP0003763_abnormal_thymus_physiology1.11112405
109MP0004782_abnormal_surfactant_physiolog1.10828700
110MP0003635_abnormal_synaptic_transmissio1.10536013
111MP0000858_altered_metastatic_potential1.10054093
112MP0008260_abnormal_autophagy1.09736690
113MP0003880_abnormal_central_pattern1.07603091
114MP0001851_eye_inflammation1.07219585
115MP0004885_abnormal_endolymph1.07099456
116MP0005085_abnormal_gallbladder_physiolo1.06598830
117MP0004215_abnormal_myocardial_fiber1.04647475
118MP0005448_abnormal_energy_balance1.04540073
119MP0000490_abnormal_crypts_of1.02798988
120MP0001873_stomach_inflammation1.02460579
121MP0005390_skeleton_phenotype1.02382668
122MP0000604_amyloidosis1.02279719
123MP0002557_abnormal_social/conspecific_i1.01374712
124MP0002063_abnormal_learning/memory/cond0.99668761
125MP0000538_abnormal_urinary_bladder0.96062758
126MP0002009_preneoplasia0.95649098
127MP0003137_abnormal_impulse_conducting0.95089383
128MP0006276_abnormal_autonomic_nervous0.94636929
129MP0004742_abnormal_vestibular_system0.93884167
130MP0005167_abnormal_blood-brain_barrier0.89886889
131MP0001324_abnormal_eye_pigmentation0.88631675
132MP0003866_abnormal_defecation0.88319363
133MP0005195_abnormal_posterior_eye0.87352319
134MP0002938_white_spotting0.87144719
135MP0002734_abnormal_mechanical_nocicepti0.86833387
136MP0002693_abnormal_pancreas_physiology0.86527819
137MP0002132_abnormal_respiratory_system0.86000652
138MP0005389_reproductive_system_phenotype0.85981301
139MP0010329_abnormal_lipoprotein_level0.84594761
140MP0000470_abnormal_stomach_morphology0.84567248
141MP0009763_increased_sensitivity_to0.83603720
142* MP0000249_abnormal_blood_vessel0.82057487
143MP0001542_abnormal_bone_strength0.82030485
144MP0009840_abnormal_foam_cell0.81872799
145MP0003633_abnormal_nervous_system0.81615834
146MP0002168_other_aberrant_phenotype0.81585327
147MP0006292_abnormal_olfactory_placode0.81261477
148MP0005164_abnormal_response_to0.80711056
149MP0005397_hematopoietic_system_phenotyp0.79347216
150MP0001545_abnormal_hematopoietic_system0.79347216
151MP0000371_diluted_coat_color0.78596218
152MP0004883_abnormal_blood_vessel0.76923963
153MP0003959_abnormal_lean_body0.76830190
154MP0002160_abnormal_reproductive_system0.75763191
155MP0002229_neurodegeneration0.75086979
156MP0005076_abnormal_cell_differentiation0.74876480
157MP0002928_abnormal_bile_duct0.72478102
158MP0003795_abnormal_bone_structure0.72461750
159MP0001664_abnormal_digestion0.71407472
160MP0008775_abnormal_heart_ventricle0.70361060
161MP0003119_abnormal_digestive_system0.68504289
162MP0005165_increased_susceptibility_to0.68160774
163MP0003631_nervous_system_phenotype0.67802644
164MP0002638_abnormal_pupillary_reflex0.67676641
165MP0001919_abnormal_reproductive_system0.66673789
166MP0010678_abnormal_skin_adnexa0.66615541
167MP0003566_abnormal_cell_adhesion0.66599296
168MP0000767_abnormal_smooth_muscle0.65714822
169MP0009278_abnormal_bone_marrow0.65621456
170MP0005171_absent_coat_pigmentation0.65241917
171MP0002751_abnormal_autonomic_nervous0.64147518
172MP0000703_abnormal_thymus_morphology0.63852854
173MP0001663_abnormal_digestive_system0.61721177
174MP0002332_abnormal_exercise_endurance0.60804293
175MP0003045_fibrosis0.60214883
176MP0001915_intracranial_hemorrhage0.58233271
177MP0002254_reproductive_system_inflammat0.56482366
178MP0000681_abnormal_thyroid_gland0.56213991
179MP0005197_abnormal_uvea_morphology0.54280708
180MP0002136_abnormal_kidney_physiology0.53289903
181MP0002095_abnormal_skin_pigmentation0.50802335
182MP0003279_aneurysm0.49560474
183MP0008873_increased_physiological_sensi0.46627643

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.70083368
2Systemic lupus erythematosus (HP:0002725)6.16882072
3Eczematoid dermatitis (HP:0000976)6.13801306
4Recurrent bacterial skin infections (HP:0005406)5.94842827
5Optic neuritis (HP:0100653)5.58300686
6Retrobulbar optic neuritis (HP:0100654)5.58300686
7Myositis (HP:0100614)5.51226117
8Orchitis (HP:0100796)5.27778276
9Recurrent gram-negative bacterial infections (HP:0005420)5.03789166
10Pancreatic cysts (HP:0001737)5.00995043
11Genetic anticipation (HP:0003743)4.73074743
12Hyperventilation (HP:0002883)4.61788694
13Glomerulonephritis (HP:0000099)4.55171385
14Pancreatic fibrosis (HP:0100732)4.36073080
15Chronic obstructive pulmonary disease (HP:0006510)4.21392659
16Obstructive lung disease (HP:0006536)4.21392659
17Abnormality of macrophages (HP:0004311)4.10548451
18True hermaphroditism (HP:0010459)4.08452489
19Protruding tongue (HP:0010808)4.07864509
20Congenital stationary night blindness (HP:0007642)4.05551747
21Increased neuronal autofluorescent lipopigment (HP:0002074)4.03023784
22Increased cerebral lipofuscin (HP:0011813)3.97121349
23Recurrent skin infections (HP:0001581)3.95370970
24Abnormality of glycolipid metabolism (HP:0010969)3.95216355
25Abnormality of liposaccharide metabolism (HP:0010968)3.95216355
26Abnormality of glycosphingolipid metabolism (HP:0004343)3.95216355
27Mediastinal lymphadenopathy (HP:0100721)3.94102497
28Vacuolated lymphocytes (HP:0001922)3.85962742
29Disinhibition (HP:0000734)3.74855692
30Abnormality of midbrain morphology (HP:0002418)3.71053228
31Molar tooth sign on MRI (HP:0002419)3.71053228
32Recurrent fungal infections (HP:0002841)3.67852244
33Gaze-evoked nystagmus (HP:0000640)3.66851989
34Progressive cerebellar ataxia (HP:0002073)3.62306381
35Elevated erythrocyte sedimentation rate (HP:0003565)3.61502626
36Clumsiness (HP:0002312)3.56567890
37Keratoconjunctivitis sicca (HP:0001097)3.53429534
38Gingivitis (HP:0000230)3.52716022
39Nephronophthisis (HP:0000090)3.40530469
40Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.31489231
41Abnormality of the renal cortex (HP:0011035)3.31235880
42Prostate neoplasm (HP:0100787)3.27528191
43Agnosia (HP:0010524)3.24765072
44Pulmonary infiltrates (HP:0002113)3.22282424
45Inability to walk (HP:0002540)3.19973721
46Chronic mucocutaneous candidiasis (HP:0002728)3.19750439
47Recurrent cutaneous fungal infections (HP:0011370)3.19750439
48Arterial thrombosis (HP:0004420)3.18924514
49Keratoconjunctivitis (HP:0001096)3.18088098
50Cystic liver disease (HP:0006706)3.17376147
51Tubular atrophy (HP:0000092)3.16304567
52Meningitis (HP:0001287)3.15311867
53Vasculitis (HP:0002633)3.14461649
54Stomatitis (HP:0010280)3.12217094
55Fair hair (HP:0002286)3.11027741
56Abnormality of the renal medulla (HP:0100957)3.10903765
57Progressive inability to walk (HP:0002505)3.09204475
58Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.09186588
59Attenuation of retinal blood vessels (HP:0007843)3.08037260
60Aplasia/Hypoplasia of the tibia (HP:0005772)3.05273212
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.02319592
62Abnormality of alanine metabolism (HP:0010916)3.02319592
63Hyperalaninemia (HP:0003348)3.02319592
64Hemoptysis (HP:0002105)2.94562698
65Birth length less than 3rd percentile (HP:0003561)2.90498955
66Large for gestational age (HP:0001520)2.89885521
67Abnormality of complement system (HP:0005339)2.88914153
68Axonal loss (HP:0003447)2.88230777
69Medial flaring of the eyebrow (HP:0010747)2.86688717
70Periodontitis (HP:0000704)2.86176251
71Furrowed tongue (HP:0000221)2.79844619
72Chronic hepatic failure (HP:0100626)2.77887417
73Pustule (HP:0200039)2.77774195
74Thick nail (HP:0001805)2.76210198
75Complement deficiency (HP:0004431)2.75962559
76Recurrent viral infections (HP:0004429)2.75225477
77Basal ganglia calcification (HP:0002135)2.74688670
78Nephritis (HP:0000123)2.74242939
79Spontaneous hematomas (HP:0007420)2.73771638
80Patellar aplasia (HP:0006443)2.66795853
81Febrile seizures (HP:0002373)2.64700590
82Abolished electroretinogram (ERG) (HP:0000550)2.64541999
83Recurrent pneumonia (HP:0006532)2.63456484
84IgM deficiency (HP:0002850)2.62905056
85Type II lissencephaly (HP:0007260)2.62342847
86Abnormality of the prostate (HP:0008775)2.60986193
87Decreased circulating renin level (HP:0003351)2.56735754
88Dysostosis multiplex (HP:0000943)2.54975388
89Chronic diarrhea (HP:0002028)2.53793218
90Absent/shortened dynein arms (HP:0200106)2.52440585
91Dynein arm defect of respiratory motile cilia (HP:0012255)2.52440585
92Generalized hypopigmentation of hair (HP:0011358)2.47207201
93Stomach cancer (HP:0012126)2.47149152
94Aplasia/Hypoplasia of the patella (HP:0006498)2.45505174
95Gangrene (HP:0100758)2.44511547
96Aplasia/Hypoplasia of the tongue (HP:0010295)2.42530837
97Osteomyelitis (HP:0002754)2.41909114
98Broad-based gait (HP:0002136)2.40183993
99Hematochezia (HP:0002573)2.39817675
100Congenital, generalized hypertrichosis (HP:0004540)2.39668543
101Glomerulopathy (HP:0100820)2.39664640
102Joint hemorrhage (HP:0005261)2.36794628
103Gait imbalance (HP:0002141)2.33685226
104Inflammation of the large intestine (HP:0002037)2.32246010
105Encephalitis (HP:0002383)2.31342009
106Urticaria (HP:0001025)2.31196630
107Abnormal drinking behavior (HP:0030082)2.30406948
108Polydipsia (HP:0001959)2.30406948
109Autoimmune thrombocytopenia (HP:0001973)2.30307265
110Hypoplastic ischia (HP:0003175)2.29409137
111Congenital hepatic fibrosis (HP:0002612)2.29323611
112Widely spaced teeth (HP:0000687)2.28726688
113Hepatosplenomegaly (HP:0001433)2.27708365
114Lissencephaly (HP:0001339)2.27245449
115Absent speech (HP:0001344)2.27228278
116Cellulitis (HP:0100658)2.26365274
117Congenital primary aphakia (HP:0007707)2.26058105
118Pulmonary embolism (HP:0002204)2.23551975
119Abnormal delayed hypersensitivity skin test (HP:0002963)2.23402039
120Anorexia (HP:0002039)2.22869175
121Recurrent lower respiratory tract infections (HP:0002783)2.21684437
122Sclerocornea (HP:0000647)2.21213344
123Abnormality of the pleura (HP:0002103)2.20113277
124Gingival bleeding (HP:0000225)2.19148895
125Congenital sensorineural hearing impairment (HP:0008527)2.18770689
126Myocardial infarction (HP:0001658)2.16286067
127Bone pain (HP:0002653)2.16130303
128Pathologic fracture (HP:0002756)2.14669224
129Chorioretinal atrophy (HP:0000533)2.12921701
130Inappropriate behavior (HP:0000719)2.10528462
131Cheilitis (HP:0100825)2.09844222
132Petechiae (HP:0000967)2.09812802
133Osteolytic defects of the phalanges of the hand (HP:0009771)2.09030246
134Osteolytic defects of the hand bones (HP:0009699)2.09030246
135Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07805072
136Nephrogenic diabetes insipidus (HP:0009806)2.05888937
137Anencephaly (HP:0002323)2.03968179
138Abnormality of the pericardium (HP:0001697)2.03263559
139Increased IgM level (HP:0003496)2.03041982
140Abnormality of the ischium (HP:0003174)2.01378990
141Cerebellar dysplasia (HP:0007033)2.01018612
142Gastrointestinal inflammation (HP:0004386)2.01005518
143Abnormality of T cell physiology (HP:0011840)2.00600924
144Leukocytosis (HP:0001974)2.00102577
145Prolonged bleeding time (HP:0003010)1.99716925
146Male pseudohermaphroditism (HP:0000037)1.98431435
147Bony spicule pigmentary retinopathy (HP:0007737)1.96602597
148Spinal cord lesions (HP:0100561)1.96524401
149Syringomyelia (HP:0003396)1.96524401
150Upper motor neuron abnormality (HP:0002127)1.96449796
151Increased corneal curvature (HP:0100692)1.96380845
152Keratoconus (HP:0000563)1.96380845
153Urinary glycosaminoglycan excretion (HP:0003541)1.96140448
154Mucopolysacchariduria (HP:0008155)1.96140448
155Macroglossia (HP:0000158)1.95079679
156Absent frontal sinuses (HP:0002688)1.94696536
157Abnormality of the lumbar spine (HP:0100712)1.94647942
158Genital tract atresia (HP:0001827)1.94617525
159Small hand (HP:0200055)1.94311856
160Abnormality of T cells (HP:0002843)1.93159337
161Abnormality of secondary sexual hair (HP:0009888)1.92840720
162Abnormality of the axillary hair (HP:0100134)1.92840720
163Dialeptic seizures (HP:0011146)1.91196646
164Abnormality of polysaccharide metabolism (HP:0011012)1.90777840
165Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90777840
166Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90777840
167Abnormal biliary tract physiology (HP:0012439)1.90743106
168Bile duct proliferation (HP:0001408)1.90743106
169Renal cortical cysts (HP:0000803)1.90681639
170Chest pain (HP:0100749)1.89771023
171Arthralgia (HP:0002829)1.89721671
172Colitis (HP:0002583)1.89602657
173Abnormality of T cell number (HP:0011839)1.89386370
174Hypoplastic labia majora (HP:0000059)1.88481162
175Decreased central vision (HP:0007663)1.88251405
176Vaginal atresia (HP:0000148)1.88052514
177Poor coordination (HP:0002370)1.87994896
178J-shaped sella turcica (HP:0002680)1.87912082
179Abnormality of the pons (HP:0007361)1.85560462
180Hypoplasia of the pons (HP:0012110)1.84554777
181Pendular nystagmus (HP:0012043)1.84196924
182Focal seizures (HP:0007359)1.81727709
183Partial agenesis of the corpus callosum (HP:0001338)1.81694735
184Focal motor seizures (HP:0011153)1.80540927
185Abnormality of the labia majora (HP:0012881)1.80464905
186Preaxial foot polydactyly (HP:0001841)1.80190674
187Short foot (HP:0001773)1.78285699
188Postaxial foot polydactyly (HP:0001830)1.75844884
189Drooling (HP:0002307)1.73611434
190Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72315595
191Preaxial hand polydactyly (HP:0001177)1.72038935
192Prominent supraorbital ridges (HP:0000336)1.71601102
193Concave nail (HP:0001598)1.71081775
194Hemiparesis (HP:0001269)1.69654633
195Polyuria (HP:0000103)1.67802152
196Dandy-Walker malformation (HP:0001305)1.67729743
197Bulbous nose (HP:0000414)1.67213628
198Amelogenesis imperfecta (HP:0000705)1.64652603

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.37327921
2BLK5.85785676
3ACVR1B4.64433238
4TXK4.23279429
5MAP3K144.07041852
6IRAK33.40888795
7IRAK43.33416172
8TGFBR23.16245572
9GRK72.71560573
10MAP4K12.61735621
11RIPK42.58874413
12TYK22.46857746
13KIT2.15791074
14CSF1R2.02796214
15AKT32.00447585
16NEK91.91747814
17TBK11.90632281
18INSRR1.87788350
19ZAP701.82091935
20JAK31.79065688
21JAK11.78707774
22SIK31.77850771
23IKBKB1.67083837
24MAP3K131.64566458
25MAPK131.62868444
26TGFBR11.59800398
27TEC1.58027593
28TLK11.56948954
29WNK31.56052511
30OXSR11.54809185
31ADRBK11.52917361
32IKBKE1.51173889
33SYK1.49823782
34CSK1.47509307
35LYN1.40439903
36BTK1.38863881
37CAMKK21.38134726
38FGR1.34010737
39MST41.32469503
40WNK41.31938920
41TAOK31.29942734
42BMPR21.29381650
43ITK1.26540207
44HCK1.25809279
45MAP3K41.24298759
46DAPK21.24022176
47STK101.23303237
48MAP3K121.21557976
49LCK1.20425738
50CLK11.17383640
51MAP4K21.15330960
52NTRK31.14543651
53ADRBK21.11876806
54EIF2AK21.10512485
55STK38L1.10038320
56MATK1.09475548
57PINK11.09383529
58JAK21.05003808
59NUAK11.03690665
60PBK1.01280206
61PIM21.01230785
62FES0.99821013
63FGFR30.98814988
64STK390.95571568
65PTK2B0.94990282
66EPHB10.94569815
67TNIK0.93741952
68BRSK20.89865270
69YES10.88380670
70PIK3CA0.88282433
71CHUK0.85620458
72PNCK0.84498339
73PIM10.79273138
74SIK20.78644458
75MOS0.77893564
76PAK30.77160078
77CAMK1G0.75221177
78MELK0.73695341
79PRKAA20.68139882
80CAMK1D0.67917235
81MAPKAPK30.67420112
82MARK30.67069369
83MKNK10.66578478
84PAK40.66390414
85PRKCG0.65577523
86ERBB30.65062376
87PRPF4B0.65034960
88EPHA30.64260281
89IRAK10.63487028
90CDK190.62567006
91NLK0.62018772
92MAP3K70.61729757
93TRPM70.61384178
94STK110.59888473
95MAP2K30.59424783
96PRKCD0.58360297
97PRKCQ0.58191407
98NEK20.57473777
99RIPK10.56294955
100STK240.55265949
101LATS10.52413176
102TIE10.51879275
103IRAK20.51122458
104STK40.50544455
105MAP2K10.49359926
106BRD40.47261670
107ABL10.46443090
108CAMK2A0.46387043
109MAPKAPK20.45595041
110CDK60.44462240
111CAMK10.44065980
112ZAK0.44039867
113MAP2K60.42796669
114MARK10.42129562
115FGFR20.42106980
116ERBB20.41483834
117BMPR1B0.40591995
118PDK10.40319179
119OBSCN0.39761810
120FYN0.39628438
121RPS6KL10.38957828
122RPS6KC10.38957828
123MAP2K70.38670411
124PRKAA10.38349864
125IGF1R0.38308159
126CASK0.38256664
127WNK10.37787041
128CAMKK10.37429387
129FLT30.37202146
130STK380.37126030
131RPS6KA60.36828285
132GRK10.34497199
133SGK2230.34466101
134SGK4940.34466101
135CSNK1D0.34466080
136CAMK40.34290991
137EGFR0.34171866
138MAPKAPK50.33840461
139PKN10.32190035
140BMX0.31409241
141STK30.31301811
142SGK20.30982900
143CHEK20.30865675
144CSNK1A1L0.30844450
145RPS6KA50.30790167
146FGFR40.30447831
147PRKACA0.29387312
148PIK3CG0.29071985
149MKNK20.28609545
150ABL20.28404824
151ERN10.28140065
152GRK50.28131796
153DAPK10.27945431
154TNK20.27483535
155SGK10.26357137
156PRKCH0.26341068
157INSR0.25445109
158MYLK0.25387077
159MAPK70.24746918
160MAPK110.24736392
161NTRK20.24709515
162ARAF0.23679937
163PRKCE0.21841667
164PRKG10.20637660

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.28268213
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.13579866
3Leishmaniasis_Homo sapiens_hsa051403.13405057
4Linoleic acid metabolism_Homo sapiens_hsa005912.77959846
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.77001450
6Nicotine addiction_Homo sapiens_hsa050332.67810576
7Phototransduction_Homo sapiens_hsa047442.63498942
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.50392908
9Nitrogen metabolism_Homo sapiens_hsa009102.49698671
10Osteoclast differentiation_Homo sapiens_hsa043802.48059688
11Asthma_Homo sapiens_hsa053102.46588745
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.45321642
13Allograft rejection_Homo sapiens_hsa053302.45106144
14Other glycan degradation_Homo sapiens_hsa005112.34931180
15Glycosaminoglycan degradation_Homo sapiens_hsa005312.28662514
16Pertussis_Homo sapiens_hsa051332.25621824
17NF-kappa B signaling pathway_Homo sapiens_hsa040642.24804184
18Lysosome_Homo sapiens_hsa041422.21240863
19Tuberculosis_Homo sapiens_hsa051522.18182853
20Legionellosis_Homo sapiens_hsa051342.07464740
21Tryptophan metabolism_Homo sapiens_hsa003802.06104457
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.04441951
23Butanoate metabolism_Homo sapiens_hsa006502.04212092
24Graft-versus-host disease_Homo sapiens_hsa053322.03458192
25Autoimmune thyroid disease_Homo sapiens_hsa053201.98743891
26Hematopoietic cell lineage_Homo sapiens_hsa046401.96174494
27Measles_Homo sapiens_hsa051621.95517639
28Phagosome_Homo sapiens_hsa041451.93465413
29Taste transduction_Homo sapiens_hsa047421.89708633
30Selenocompound metabolism_Homo sapiens_hsa004501.89705425
31Rheumatoid arthritis_Homo sapiens_hsa053231.89389197
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.88486723
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.88125650
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85797909
35Malaria_Homo sapiens_hsa051441.77091310
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.68792073
37Salmonella infection_Homo sapiens_hsa051321.64346501
38Primary immunodeficiency_Homo sapiens_hsa053401.64007722
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62813697
40Morphine addiction_Homo sapiens_hsa050321.61071149
41Chemokine signaling pathway_Homo sapiens_hsa040621.58478696
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.57512004
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.57158510
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.49856818
45Toxoplasmosis_Homo sapiens_hsa051451.49147655
46Influenza A_Homo sapiens_hsa051641.48289123
47B cell receptor signaling pathway_Homo sapiens_hsa046621.47653336
48Olfactory transduction_Homo sapiens_hsa047401.44617342
49Antigen processing and presentation_Homo sapiens_hsa046121.42710945
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.42253098
51Glutamatergic synapse_Homo sapiens_hsa047241.40841516
52Serotonergic synapse_Homo sapiens_hsa047261.37782847
53Circadian entrainment_Homo sapiens_hsa047131.37344652
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.33937590
55Dorso-ventral axis formation_Homo sapiens_hsa043201.31216793
56Homologous recombination_Homo sapiens_hsa034401.28823112
57Maturity onset diabetes of the young_Homo sapiens_hsa049501.28405210
58TNF signaling pathway_Homo sapiens_hsa046681.26571217
59Herpes simplex infection_Homo sapiens_hsa051681.26424831
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.23375259
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22882291
62Ovarian steroidogenesis_Homo sapiens_hsa049131.20319405
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16003898
64Histidine metabolism_Homo sapiens_hsa003401.13960108
65Shigellosis_Homo sapiens_hsa051311.13832202
66T cell receptor signaling pathway_Homo sapiens_hsa046601.12278934
67Primary bile acid biosynthesis_Homo sapiens_hsa001201.12245209
68Apoptosis_Homo sapiens_hsa042101.10260690
69African trypanosomiasis_Homo sapiens_hsa051431.07658733
70GABAergic synapse_Homo sapiens_hsa047271.07138412
71Complement and coagulation cascades_Homo sapiens_hsa046101.06905130
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06409762
73Salivary secretion_Homo sapiens_hsa049701.06372539
74Long-term depression_Homo sapiens_hsa047301.06284295
75Vascular smooth muscle contraction_Homo sapiens_hsa042701.05686851
76Glycerolipid metabolism_Homo sapiens_hsa005611.04613765
77* Calcium signaling pathway_Homo sapiens_hsa040201.02422799
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00653936
79Insulin secretion_Homo sapiens_hsa049111.00176645
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97210176
81Fanconi anemia pathway_Homo sapiens_hsa034600.96703598
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.95972489
83Chemical carcinogenesis_Homo sapiens_hsa052040.95721988
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93961544
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93239767
86Hepatitis B_Homo sapiens_hsa051610.91914547
87Type I diabetes mellitus_Homo sapiens_hsa049400.91255654
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91137900
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90871174
90Viral myocarditis_Homo sapiens_hsa054160.89896667
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88253198
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85197423
93Cholinergic synapse_Homo sapiens_hsa047250.85129387
94Retinol metabolism_Homo sapiens_hsa008300.81814035
95Basal transcription factors_Homo sapiens_hsa030220.79989738
96Oxytocin signaling pathway_Homo sapiens_hsa049210.79406134
97Lysine degradation_Homo sapiens_hsa003100.78514328
98Gastric acid secretion_Homo sapiens_hsa049710.76640378
99Platelet activation_Homo sapiens_hsa046110.75297051
100Fatty acid biosynthesis_Homo sapiens_hsa000610.73741500
101cAMP signaling pathway_Homo sapiens_hsa040240.71867652
102Dopaminergic synapse_Homo sapiens_hsa047280.70195174
103Renin secretion_Homo sapiens_hsa049240.68620596
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.67604417
105Prion diseases_Homo sapiens_hsa050200.67536915
106Hepatitis C_Homo sapiens_hsa051600.66147193
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65430733
108Amoebiasis_Homo sapiens_hsa051460.64089056
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62106636
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61026682
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60891183
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60441426
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59902929
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57466339
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56413837
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53048365
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52597869
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51808634
119Circadian rhythm_Homo sapiens_hsa047100.51007990
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50421086
121Amphetamine addiction_Homo sapiens_hsa050310.50084954
122Cocaine addiction_Homo sapiens_hsa050300.49972708
123Pancreatic cancer_Homo sapiens_hsa052120.49536886
124Peroxisome_Homo sapiens_hsa041460.49432066
125Sphingolipid metabolism_Homo sapiens_hsa006000.48427088
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44987410
127beta-Alanine metabolism_Homo sapiens_hsa004100.42812785
128Acute myeloid leukemia_Homo sapiens_hsa052210.42528347
129Arachidonic acid metabolism_Homo sapiens_hsa005900.42374634
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41733765
131Vitamin digestion and absorption_Homo sapiens_hsa049770.41601082
132Pancreatic secretion_Homo sapiens_hsa049720.40665697
133One carbon pool by folate_Homo sapiens_hsa006700.40113737
134* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38986802
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38045207
136Endocytosis_Homo sapiens_hsa041440.37848384
137Ras signaling pathway_Homo sapiens_hsa040140.34819840
138Collecting duct acid secretion_Homo sapiens_hsa049660.34095148
139Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33249621
140Propanoate metabolism_Homo sapiens_hsa006400.33222073
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31939655
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31729187
143Epstein-Barr virus infection_Homo sapiens_hsa051690.31397661
144Renin-angiotensin system_Homo sapiens_hsa046140.30938009
145ABC transporters_Homo sapiens_hsa020100.29835183
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.29356121
147Notch signaling pathway_Homo sapiens_hsa043300.26332868
148Neurotrophin signaling pathway_Homo sapiens_hsa047220.25753454
149Caffeine metabolism_Homo sapiens_hsa002320.22323154
150Mineral absorption_Homo sapiens_hsa049780.22114970
151HTLV-I infection_Homo sapiens_hsa051660.22113888
152Ether lipid metabolism_Homo sapiens_hsa005650.21185854
153Systemic lupus erythematosus_Homo sapiens_hsa053220.19556806
154HIF-1 signaling pathway_Homo sapiens_hsa040660.19464094
155Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18828141
156Viral carcinogenesis_Homo sapiens_hsa052030.18182735
157Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18154174
158Chronic myeloid leukemia_Homo sapiens_hsa052200.17602752
159MAPK signaling pathway_Homo sapiens_hsa040100.16492254
160Prolactin signaling pathway_Homo sapiens_hsa049170.14947069
161Rap1 signaling pathway_Homo sapiens_hsa040150.13032253
162FoxO signaling pathway_Homo sapiens_hsa040680.12560655
163Type II diabetes mellitus_Homo sapiens_hsa049300.12429166
164Small cell lung cancer_Homo sapiens_hsa052220.11551666
165Regulation of autophagy_Homo sapiens_hsa041400.10088575
166Proteoglycans in cancer_Homo sapiens_hsa052050.09553943
167Adherens junction_Homo sapiens_hsa045200.09434555

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