CYP4Z2P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1prostate gland growth (GO:0060736)8.63945833
2mammary gland epithelial cell differentiation (GO:0060644)7.16315954
3purine nucleotide transport (GO:0015865)7.14494146
4iron ion import (GO:0097286)6.06652152
5activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)5.97327575
6dichotomous subdivision of an epithelial terminal unit (GO:0060600)5.62070649
7regulation of water loss via skin (GO:0033561)5.56433914
8mammary gland alveolus development (GO:0060749)5.33455408
9positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)5.32258880
10establishment of skin barrier (GO:0061436)5.21500058
11Golgi transport vesicle coating (GO:0048200)5.02432376
12COPI coating of Golgi vesicle (GO:0048205)5.02432376
13diol metabolic process (GO:0034311)4.84031917
14ovulation from ovarian follicle (GO:0001542)4.81365358
15growth hormone receptor signaling pathway (GO:0060396)4.78544205
16insulin-like growth factor receptor signaling pathway (GO:0048009)4.68596974
17surfactant homeostasis (GO:0043129)4.65997381
18lung lobe morphogenesis (GO:0060463)4.63411435
19multicellular organismal water homeostasis (GO:0050891)4.58918425
20NLS-bearing protein import into nucleus (GO:0006607)4.57605068
21keratinocyte development (GO:0003334)4.47908475
22desmosome organization (GO:0002934)4.36782306
23epithelial cell maturation (GO:0002070)4.34461018
24intestinal epithelial cell development (GO:0060576)4.32856605
25negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)4.30533888
26biotin metabolic process (GO:0006768)4.27689744
27sphingoid metabolic process (GO:0046519)4.16388749
28cellular response to growth hormone stimulus (GO:0071378)4.14354339
29cardiac right ventricle morphogenesis (GO:0003215)4.07070907
30water homeostasis (GO:0030104)4.04775989
31myoblast migration (GO:0051451)4.00777566
32nucleotide transport (GO:0006862)3.86088951
33benzene-containing compound metabolic process (GO:0042537)3.84299107
34chemical homeostasis within a tissue (GO:0048875)3.77720154
35regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.71997337
36calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.70506299
37epithelial cell-cell adhesion (GO:0090136)3.67566652
38short-chain fatty acid metabolic process (GO:0046459)3.59336023
39regulation of hippo signaling (GO:0035330)3.59131474
40face development (GO:0060324)3.56395966
41phosphatidylinositol 3-kinase signaling (GO:0014065)3.50757571
42cytoskeletal anchoring at plasma membrane (GO:0007016)3.49512538
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.48148564
44regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.44178548
45regulation of cytokine production involved in inflammatory response (GO:1900015)3.38635035
46sphingomyelin metabolic process (GO:0006684)3.34270494
47JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.29860363
48white fat cell differentiation (GO:0050872)3.27702138
49tight junction assembly (GO:0070830)3.26699971
50ectoderm development (GO:0007398)3.24122189
51endocrine hormone secretion (GO:0060986)3.22528068
52embryo implantation (GO:0007566)3.21080544
53prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.19675380
54epithelial cell differentiation involved in prostate gland development (GO:0060742)3.19099468
55negative regulation of cell-matrix adhesion (GO:0001953)3.18678124
56primary alcohol catabolic process (GO:0034310)3.17487796
57regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.16658441
58regulation of histone deacetylation (GO:0031063)3.15711822
59ear development (GO:0043583)3.14849570
60valine metabolic process (GO:0006573)3.09640762
61regulation of protein polyubiquitination (GO:1902914)3.08241633
62muscle cell migration (GO:0014812)3.07582842
63positive regulation of keratinocyte differentiation (GO:0045618)3.07521571
64bundle of His cell to Purkinje myocyte communication (GO:0086069)3.07371159
65sphingosine metabolic process (GO:0006670)3.05311572
66trivalent inorganic anion homeostasis (GO:0072506)3.05013964
67phosphate ion homeostasis (GO:0055062)3.05013964
68regulation of establishment or maintenance of cell polarity (GO:0032878)3.03512093
69peripheral nervous system axon ensheathment (GO:0032292)3.02642574
70myelination in peripheral nervous system (GO:0022011)3.02642574
71cilium or flagellum-dependent cell motility (GO:0001539)2.98553956
72motile cilium assembly (GO:0044458)2.98145511
73retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.92005924
74regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.90072519
75regulation of protein localization to cell surface (GO:2000008)2.89313730
76dicarboxylic acid biosynthetic process (GO:0043650)2.88744513
77branching involved in mammary gland duct morphogenesis (GO:0060444)2.88329477
78Golgi to endosome transport (GO:0006895)2.87010724
79proline biosynthetic process (GO:0006561)2.86422414
80endothelial cell chemotaxis (GO:0035767)2.85944678
81cardiac ventricle morphogenesis (GO:0003208)2.84246087
82smooth muscle tissue development (GO:0048745)2.83764251
83glutathione biosynthetic process (GO:0006750)2.83303189
84embryonic cranial skeleton morphogenesis (GO:0048701)2.81730210
85exocrine pancreas development (GO:0031017)2.81611483
86regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.81450099
87regulation of hydrogen peroxide metabolic process (GO:0010310)2.79884793
88keratan sulfate catabolic process (GO:0042340)2.75713370
89response to growth hormone (GO:0060416)2.73351370
90retina homeostasis (GO:0001895)2.70317160
91amyloid precursor protein catabolic process (GO:0042987)2.67524826
92macroautophagy (GO:0016236)2.64024899
93ethanol metabolic process (GO:0006067)2.63562333
94positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.61888916
95peptidyl-lysine dimethylation (GO:0018027)2.60502899
96apical protein localization (GO:0045176)2.59954451
97positive regulation of cell size (GO:0045793)2.59155457
98O-glycan processing (GO:0016266)2.56923509
99proline metabolic process (GO:0006560)2.55612548
100cardiac chamber morphogenesis (GO:0003206)2.55504347

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR2_21235772_ChIP-Seq_MCF-7_Human4.95042045
2ESR1_21235772_ChIP-Seq_MCF-7_Human4.51223049
3ZNF217_24962896_ChIP-Seq_MCF-7_Human4.04091125
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.01486846
5ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.94547435
6AHR_22903824_ChIP-Seq_MCF-7_Human3.21290517
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.81090428
8TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.76954049
9FOXM1_26456572_ChIP-Seq_MCF-7_Human2.74054795
10ELF5_23300383_ChIP-Seq_T47D_Human2.70404881
11ARNT_22903824_ChIP-Seq_MCF-7_Human2.65640643
12ESR1_15608294_ChIP-ChIP_MCF-7_Human2.53551900
13ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.47405181
14GATA3_24758297_ChIP-Seq_MCF-7_Human2.47135627
15* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.43436626
16RUNX1_27514584_Chip-Seq_MCF-7_Human2.33512194
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19789370
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.09280452
19RACK7_27058665_Chip-Seq_MCF-7_Human2.07395381
20FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.03411325
21ESR1_20079471_ChIP-ChIP_T-47D_Human11.0056169
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.97807363
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.93132828
24SOX2_27498859_Chip-Seq_STOMACH_Mouse1.79146265
25SOX9_24532713_ChIP-Seq_HFSC_Mouse1.77661136
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.74973120
27ZNF263_19887448_ChIP-Seq_K562_Human1.71090329
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.68980521
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.68580311
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.67487945
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57410158
32AR_21909140_ChIP-Seq_LNCAP_Human1.57387214
33AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.54220477
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49450513
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.49058314
36SOX2_20726797_ChIP-Seq_SW620_Human1.44813406
37FOXA1_25552417_ChIP-Seq_VCAP_Human1.44151375
38GATA6_25053715_ChIP-Seq_YYC3_Human1.43955673
39ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.43213199
40SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.40254181
41SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.40254181
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37425743
43CDX2_20551321_ChIP-Seq_CACO-2_Human1.35900322
44GATA4_25053715_ChIP-Seq_YYC3_Human1.35206365
45CLOCK_20551151_ChIP-Seq_293T_Human1.32555813
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27704904
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24758092
48HOXB7_26014856_ChIP-Seq_BT474_Human1.24750857
49PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22551764
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22477908
51FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22211599
52RXR_22158963_ChIP-Seq_LIVER_Mouse1.19170654
53CHD1_26751641_Chip-Seq_LNCaP_Human1.18029548
54P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16771882
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.16163616
56LXR_22158963_ChIP-Seq_LIVER_Mouse1.15097913
57KLF5_25053715_ChIP-Seq_YYC3_Human1.11987170
58ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11202480
59CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10001871
60CJUN_26792858_Chip-Seq_BT549_Human1.09615975
61FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.09168408
62TBX20_22328084_ChIP-Seq_HEART_Mouse1.09142344
63TBX20_22080862_ChIP-Seq_HEART_Mouse1.09142344
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08406287
65BCAT_22108803_ChIP-Seq_LS180_Human1.06371406
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00936161
67FOXA2_19822575_ChIP-Seq_HepG2_Human0.98514320
68CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96157126
69KDM5A_27292631_Chip-Seq_BREAST_Human0.94468134
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92962660
71EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92788889
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89215734
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87896532
74PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87570358
75PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83123103
76ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.81152073
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.78053753
78RARG_19884340_ChIP-ChIP_MEFs_Mouse0.77651614
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.75855314
80* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.75263449
81CBP_21632823_ChIP-Seq_H3396_Human0.74681412
82ER_23166858_ChIP-Seq_MCF-7_Human0.73231527
83SMC4_20622854_ChIP-Seq_HELA_Human0.68804777
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.68185446
85TP63_23658742_ChIP-Seq_EP156T_Human0.67231102
86NFIB_24661679_ChIP-Seq_LUNG_Mouse0.67036089
87AR_21572438_ChIP-Seq_LNCaP_Human0.65249290
88* CREB1_26743006_Chip-Seq_LNCaP_Human0.64119097
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.61390506
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.61329876
91NRF2_20460467_ChIP-Seq_MEFs_Mouse0.61163354
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.61163354
93GATA1_22025678_ChIP-Seq_K562_Human0.60987579
94CDX2_22108803_ChIP-Seq_LS180_Human0.60876071
95SOX2_18555785_Chip-Seq_ESCs_Mouse0.60799823
96ZFX_18555785_Chip-Seq_ESCs_Mouse0.60561740
97SALL4_18804426_ChIP-ChIP_XEN_Mouse0.60114858
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.59559283
99NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.58703129
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.58019959

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001346_abnormal_lacrimal_gland5.41529972
2MP0010234_abnormal_vibrissa_follicle4.73348950
3MP0003183_abnormal_peptide_metabolism4.38412061
4MP0005248_abnormal_Harderian_gland4.32873012
5MP0004264_abnormal_extraembryonic_tissu3.79813671
6MP0002254_reproductive_system_inflammat3.57849739
7MP0009384_cardiac_valve_regurgitation3.25458661
8MP0002009_preneoplasia3.12429270
9MP0000427_abnormal_hair_cycle2.89701138
10MP0002796_impaired_skin_barrier2.84876926
11MP0003191_abnormal_cellular_cholesterol2.72117651
12MP0009780_abnormal_chondrocyte_physiolo2.59980115
13MP0005275_abnormal_skin_tensile2.59104341
14MP0002282_abnormal_trachea_morphology2.58107921
15MP0005379_endocrine/exocrine_gland_phen2.50519416
16MP0005503_abnormal_tendon_morphology2.43779154
17MP0003941_abnormal_skin_development2.40980755
18MP0002098_abnormal_vibrissa_morphology2.34250200
19MP0001881_abnormal_mammary_gland2.29023539
20MP0005083_abnormal_biliary_tract2.20991976
21MP0002166_altered_tumor_susceptibility2.19418239
22MP0000627_abnormal_mammary_gland2.19304939
23MP0001873_stomach_inflammation2.17337612
24MP0005408_hypopigmentation1.99946981
25MP0003724_increased_susceptibility_to1.99554984
26MP0001919_abnormal_reproductive_system1.98184058
27MP0010678_abnormal_skin_adnexa1.87652522
28MP0004782_abnormal_surfactant_physiolog1.78539097
29MP0003045_fibrosis1.69568702
30MP0002108_abnormal_muscle_morphology1.69250673
31MP0001661_extended_life_span1.66518602
32MP0001177_atelectasis1.62595553
33MP0001727_abnormal_embryo_implantation1.57536757
34MP0000377_abnormal_hair_follicle1.56360425
35MP0001879_abnormal_lymphatic_vessel1.54675563
36MP0005501_abnormal_skin_physiology1.47139824
37MP0003279_aneurysm1.46121253
38MP0000383_abnormal_hair_follicle1.39852687
39MP0000681_abnormal_thyroid_gland1.34857520
40MP0000537_abnormal_urethra_morphology1.33143325
41MP0008004_abnormal_stomach_pH1.32906498
42MP0002896_abnormal_bone_mineralization1.32203920
43MP0002006_tumorigenesis1.27196944
44MP0008438_abnormal_cutaneous_collagen1.26576666
45MP0003936_abnormal_reproductive_system1.23475197
46MP0002168_other_aberrant_phenotype1.19791730
47MP0001765_abnormal_ion_homeostasis1.17044235
48MP0000613_abnormal_salivary_gland1.14543620
49MP0001958_emphysema1.08287671
50MP0010352_gastrointestinal_tract_polyps1.07644677
51MP0001666_abnormal_nutrient_absorption1.07457274
52MP0005646_abnormal_pituitary_gland1.07207024
53MP0008995_early_reproductive_senescence1.05176014
54MP0003566_abnormal_cell_adhesion1.03343268
55MP0000767_abnormal_smooth_muscle1.02646010
56MP0005389_reproductive_system_phenotype1.01740246
57MP0005636_abnormal_mineral_homeostasis1.01417220
58MP0008057_abnormal_DNA_replication0.99900992
59MP0002060_abnormal_skin_morphology0.95869565
60MP0005310_abnormal_salivary_gland0.94818565
61MP0003705_abnormal_hypodermis_morpholog0.88103641
62MP0002933_joint_inflammation0.87867160
63MP0006138_congestive_heart_failure0.87360702
64MP0001216_abnormal_epidermal_layer0.87343523
65MP0005187_abnormal_penis_morphology0.85164732
66MP0000163_abnormal_cartilage_morphology0.79594165
67MP0004381_abnormal_hair_follicle0.76875721
68MP0000566_synostosis0.76594281
69MP0000647_abnormal_sebaceous_gland0.74922130
70MP0003638_abnormal_response/metabolism_0.74118211
71MP0008961_abnormal_basal_metabolism0.72458045
72MP0002877_abnormal_melanocyte_morpholog0.72225936
73MP0003938_abnormal_ear_development0.71616032
74MP0000751_myopathy0.71579041
75MP0000367_abnormal_coat/_hair0.70835655
76MP0003950_abnormal_plasma_membrane0.69907703
77MP0004272_abnormal_basement_membrane0.69773129
78MP0002133_abnormal_respiratory_system0.69001693
79MP0005388_respiratory_system_phenotype0.69001693
80MP0000579_abnormal_nail_morphology0.67325655
81MP0004036_abnormal_muscle_relaxation0.67148457
82MP0004084_abnormal_cardiac_muscle0.66977132
83MP0010771_integument_phenotype0.64991570
84MP0003453_abnormal_keratinocyte_physiol0.63112389
85MP0002115_abnormal_skeleton_extremities0.61809487
86MP0001756_abnormal_urination0.58168682
87MP0003300_gastrointestinal_ulcer0.57374329
88MP0010030_abnormal_orbit_morphology0.56811648
89MP0000762_abnormal_tongue_morphology0.55618008
90MP0009931_abnormal_skin_appearance0.55607634
91MP0001664_abnormal_digestion0.55286540
92MP0003795_abnormal_bone_structure0.55260381
93MP0005395_other_phenotype0.53207117
94MP0002909_abnormal_adrenal_gland0.51900144
95MP0005508_abnormal_skeleton_morphology0.51669955
96MP0002876_abnormal_thyroid_physiology0.51304426
97MP0002113_abnormal_skeleton_development0.51012108
98MP0001849_ear_inflammation0.50903630
99MP0003868_abnormal_feces_composition0.48782162
100MP0000462_abnormal_digestive_system0.48186425

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)7.71368097
2Sparse lateral eyebrow (HP:0005338)7.48637622
3Abnormality of nail color (HP:0100643)6.49758932
4Flat capital femoral epiphysis (HP:0003370)6.25707037
5Oligomenorrhea (HP:0000876)5.98832612
6Abnormality of the proximal phalanges of the hand (HP:0009834)5.62099226
7Deep philtrum (HP:0002002)5.55354883
8Infantile muscular hypotonia (HP:0008947)4.87456821
9Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)4.65442396
10Breast carcinoma (HP:0003002)4.11479996
11Right ventricular cardiomyopathy (HP:0011663)4.10290427
12Abnormality of the epiphyses of the hand (HP:0005924)4.00757972
13Pulmonary artery stenosis (HP:0004415)3.92904005
14Lip pit (HP:0100267)3.89853657
15Abnormality involving the epiphyses of the upper limbs (HP:0003839)3.80565609
16Exostoses (HP:0100777)3.73929485
17Abnormality of the astrocytes (HP:0100707)3.72397040
18Astrocytoma (HP:0009592)3.72397040
19Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)3.61006352
20Chronic sinusitis (HP:0011109)3.54325841
21Spontaneous abortion (HP:0005268)3.42709526
22Recurrent bronchitis (HP:0002837)3.32363569
23Abnormal cartilage morphology (HP:0002763)3.29718909
24Pili torti (HP:0003777)3.27186125
25Menorrhagia (HP:0000132)3.25926636
26Interstitial pulmonary disease (HP:0006530)3.16015226
27Hamartoma of the eye (HP:0010568)2.96497547
28Bronchitis (HP:0012387)2.95423376
29Tubulointerstitial nephritis (HP:0001970)2.94775303
30Ependymoma (HP:0002888)2.88886943
31Glioma (HP:0009733)2.88012479
32Infertility (HP:0000789)2.86943043
33Abnormality of the femoral head (HP:0003368)2.81803624
34Curly hair (HP:0002212)2.78271084
35Abnormality of the epiphysis of the femoral head (HP:0010574)2.67819947
36Cone-rod dystrophy (HP:0000548)2.61039547
37Macroorchidism (HP:0000053)2.55676588
38Abnormality of the parathyroid morphology (HP:0011766)2.55112002
39Pheochromocytoma (HP:0002666)2.55092963
40Osteoarthritis (HP:0002758)2.53595995
41Absent/shortened dynein arms (HP:0200106)2.52847540
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.52847540
43Abnormality of femoral epiphyses (HP:0006499)2.48615240
44Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.48615240
45Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.48066067
46Chronic bronchitis (HP:0004469)2.41692186
47Thin bony cortex (HP:0002753)2.33065787
48Increased number of teeth (HP:0011069)2.30550435
49Abnormality of the distal phalanges of the toes (HP:0010182)2.29070407
50Rhinitis (HP:0012384)2.25816193
51Narrow palate (HP:0000189)2.22549399
52Underdeveloped nasal alae (HP:0000430)2.18147464
53Tracheal stenosis (HP:0002777)2.17890729
54Scapular winging (HP:0003691)2.16578998
55Cervical subluxation (HP:0003308)2.16406425
56Smooth philtrum (HP:0000319)2.15195602
57Abnormal hair laboratory examination (HP:0003328)2.13287560
58Severe Myopia (HP:0011003)2.11902358
59Neuroendocrine neoplasm (HP:0100634)2.11252069
60Chondrocalcinosis (HP:0000934)2.08426841
61Short hallux (HP:0010109)2.07987818
62Bell-shaped thorax (HP:0001591)2.07524576
63Testicular atrophy (HP:0000029)2.07049095
64Abnormality of Sharpey fibers (HP:0100685)2.04932105
65Short nail (HP:0001799)2.03950818
66Germ cell neoplasia (HP:0100728)2.02725839
67Epiphyseal stippling (HP:0010655)2.02189687
68Subcapsular cataract (HP:0000523)2.02061440
69Osteolytic defects of the phalanges of the hand (HP:0009771)1.99660743
70Osteolytic defects of the hand bones (HP:0009699)1.99660743
71Acanthosis nigricans (HP:0000956)1.91646766
72Testicular neoplasm (HP:0010788)1.90051394
73Congenital ichthyosiform erythroderma (HP:0007431)1.88094992
74Hyperactive renin-angiotensin system (HP:0000841)1.85483297
75Aplasia/Hypoplasia of the hallux (HP:0008362)1.85014192
76Microdontia (HP:0000691)1.84736087
77Lymphangioma (HP:0100764)1.83180481
78Nasal speech (HP:0001611)1.82844399
79Mucopolysacchariduria (HP:0008155)1.81981740
80Urinary glycosaminoglycan excretion (HP:0003541)1.81981740
81Decreased circulating renin level (HP:0003351)1.81732768
82Flat acetabular roof (HP:0003180)1.79841695
83Abnormal respiratory motile cilium physiology (HP:0012261)1.78680561
84Overgrowth (HP:0001548)1.75901760
85Abnormality of the nasal septum (HP:0000419)1.75448148
86Hyperkalemia (HP:0002153)1.75325910
87Short metatarsal (HP:0010743)1.74567319
88Broad metatarsal (HP:0001783)1.73436569
89Parakeratosis (HP:0001036)1.72393281
90Spinal cord compression (HP:0002176)1.72251158
91Hypotrichosis (HP:0001006)1.71399218
92Bone pain (HP:0002653)1.71176744
93Slow-growing hair (HP:0002217)1.70310606
94Abnormality of hair growth rate (HP:0011363)1.70310606
95Abnormal ciliary motility (HP:0012262)1.68915122
96Sparse eyelashes (HP:0000653)1.66197368
97Enlarged epiphyses (HP:0010580)1.63926538
98Abnormality of the dental root (HP:0006486)1.62148192
99Taurodontia (HP:0000679)1.62148192
100Abnormality of permanent molar morphology (HP:0011071)1.62148192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.15414608
2TESK13.91218289
3EPHA23.69547385
4FER3.53999048
5STK243.52796001
6TRIB33.39475152
7MAPKAPK33.08177574
8PKN22.63356596
9BRSK22.61326762
10TNK22.54564250
11EPHA32.37594383
12LATS12.24843005
13MST1R2.18063308
14EEF2K2.00168437
15FGFR41.87186990
16RIPK11.78779649
17JAK21.77489708
18ERBB21.68650460
19ILK1.68558817
20SIK11.60424036
21MET1.60402045
22PRKCI1.60146935
23MAPK151.59903380
24LIMK11.57942466
25DMPK1.54794266
26RPS6KB21.43755515
27LRRK21.33962610
28STK38L1.33326252
29NEK61.25034500
30TSSK61.23817377
31PTK21.19798824
32MATK1.19212857
33JAK11.09480940
34WEE11.08529473
35SCYL21.06582388
36PDGFRB1.03924717
37MAP3K31.02362484
38PIK3CA0.97477883
39PIK3CG0.95101397
40PRKAA20.93488351
41EPHB10.90514157
42PDGFRA0.84047510
43CDK120.83853842
44RET0.83121503
45EIF2AK10.82167313
46LATS20.81540488
47PTK60.80599057
48BRSK10.79919967
49ZAP700.78686679
50PAK40.75656354
51FRK0.75614478
52MTOR0.74909169
53PRKD10.67719122
54PAK30.65003486
55MAP3K140.63862721
56RPS6KA20.60929782
57ERBB30.59068785
58SGK30.59048902
59CDK70.58604479
60CHUK0.57777347
61TAF10.55906531
62MAP2K10.55675149
63MAP3K60.54160129
64CSNK1E0.54105705
65ICK0.51325941
66YES10.50722964
67MAP2K60.47850027
68EIF2AK30.47467691
69PBK0.44880102
70STK390.44471229
71TRPM70.44017605
72AKT30.41547050
73IRAK10.41077653
74MARK20.39546219
75NME10.38199628
76MYLK0.38065232
77SGK20.37361189
78EGFR0.37139705
79TBK10.36781767
80BMPR20.36052655
81IGF1R0.35890873
82MAP3K20.34412109
83IKBKE0.32998495
84BTK0.31848918
85MAPKAPK50.29676544
86MAP3K130.29626031
87FGFR30.27785985
88TGFBR20.27715067
89ROCK10.27702936
90PAK20.27607038
91MAP3K70.27087169
92RPS6KB10.26953921
93MUSK0.25452907
94AKT20.25065650
95HIPK20.24124591
96MAPK80.23729574
97PRKAA10.23238498
98STK30.22227629
99CDK30.21370724
100NEK90.20781301

Predicted pathways (KEGG)

RankGene SetZ-score
1ABC transporters_Homo sapiens_hsa020105.19981104
2Sphingolipid metabolism_Homo sapiens_hsa006002.90986684
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.75308554
4Phenylalanine metabolism_Homo sapiens_hsa003602.51483991
5ECM-receptor interaction_Homo sapiens_hsa045122.23610738
6Tyrosine metabolism_Homo sapiens_hsa003502.18892386
7Prolactin signaling pathway_Homo sapiens_hsa049172.09169161
8Histidine metabolism_Homo sapiens_hsa003402.03643419
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.83528261
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.79935051
11Caffeine metabolism_Homo sapiens_hsa002321.77781781
12Leukocyte transendothelial migration_Homo sapiens_hsa046701.76446485
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.69694120
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66128634
15Fatty acid biosynthesis_Homo sapiens_hsa000611.62153383
16Circadian rhythm_Homo sapiens_hsa047101.58168176
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.53617375
18Tight junction_Homo sapiens_hsa045301.52354364
19Glutathione metabolism_Homo sapiens_hsa004801.41123816
20Focal adhesion_Homo sapiens_hsa045101.39331664
21Sulfur metabolism_Homo sapiens_hsa009201.38532984
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.38195484
23Endometrial cancer_Homo sapiens_hsa052131.38130035
24Peroxisome_Homo sapiens_hsa041461.34190145
25Hepatitis C_Homo sapiens_hsa051601.29550801
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24537436
27Longevity regulating pathway - mammal_Homo sapiens_hsa042111.20394939
28Prostate cancer_Homo sapiens_hsa052151.18036317
29Thyroid cancer_Homo sapiens_hsa052161.17159915
30Pancreatic cancer_Homo sapiens_hsa052121.16473916
31beta-Alanine metabolism_Homo sapiens_hsa004101.14950593
32Fatty acid elongation_Homo sapiens_hsa000621.09951225
33Chemical carcinogenesis_Homo sapiens_hsa052041.09817767
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09474730
35Estrogen signaling pathway_Homo sapiens_hsa049151.08657549
36Mineral absorption_Homo sapiens_hsa049781.05449714
37Proteoglycans in cancer_Homo sapiens_hsa052051.04862619
38N-Glycan biosynthesis_Homo sapiens_hsa005100.99924581
39Other glycan degradation_Homo sapiens_hsa005110.99619953
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98648086
41Dilated cardiomyopathy_Homo sapiens_hsa054140.96962108
42Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94902520
43Adherens junction_Homo sapiens_hsa045200.91455018
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90938000
45AMPK signaling pathway_Homo sapiens_hsa041520.89126849
46PPAR signaling pathway_Homo sapiens_hsa033200.87292375
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.85470974
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85288788
49Renal cell carcinoma_Homo sapiens_hsa052110.84585162
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.82269186
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81325371
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78997859
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.78565050
54Pancreatic secretion_Homo sapiens_hsa049720.78327905
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.77793060
56Insulin resistance_Homo sapiens_hsa049310.77605176
57Fatty acid metabolism_Homo sapiens_hsa012120.77602871
58Inositol phosphate metabolism_Homo sapiens_hsa005620.77165120
59Fatty acid degradation_Homo sapiens_hsa000710.77095027
60ErbB signaling pathway_Homo sapiens_hsa040120.76873979
61PI3K-Akt signaling pathway_Homo sapiens_hsa041510.75168731
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74668992
63mTOR signaling pathway_Homo sapiens_hsa041500.73354838
64Choline metabolism in cancer_Homo sapiens_hsa052310.73101558
65Butanoate metabolism_Homo sapiens_hsa006500.70781705
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68146097
67Lysosome_Homo sapiens_hsa041420.67544095
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66592766
69Endocytosis_Homo sapiens_hsa041440.65334477
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64223012
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63796737
72Non-small cell lung cancer_Homo sapiens_hsa052230.61054084
73VEGF signaling pathway_Homo sapiens_hsa043700.60037063
74Tryptophan metabolism_Homo sapiens_hsa003800.59582029
75Renin secretion_Homo sapiens_hsa049240.59537445
76Ovarian steroidogenesis_Homo sapiens_hsa049130.59500977
77Chronic myeloid leukemia_Homo sapiens_hsa052200.57695177
78Malaria_Homo sapiens_hsa051440.57012234
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56543583
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55911471
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54536919
82Nitrogen metabolism_Homo sapiens_hsa009100.54248394
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.49701573
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49609150
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.48205873
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47989979
87Insulin signaling pathway_Homo sapiens_hsa049100.47975675
88HIF-1 signaling pathway_Homo sapiens_hsa040660.46360221
89Small cell lung cancer_Homo sapiens_hsa052220.46211983
90Bladder cancer_Homo sapiens_hsa052190.45111756
91Hippo signaling pathway_Homo sapiens_hsa043900.44823100
92FoxO signaling pathway_Homo sapiens_hsa040680.42984240
93Notch signaling pathway_Homo sapiens_hsa043300.42714733
94Amoebiasis_Homo sapiens_hsa051460.42451270
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41702053
96Acute myeloid leukemia_Homo sapiens_hsa052210.41346738
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40846501
98Arginine and proline metabolism_Homo sapiens_hsa003300.40519350
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39295721
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39178116

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