CYP4F24P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1auditory receptor cell differentiation (GO:0042491)6.87601331
2glycerophospholipid catabolic process (GO:0046475)4.68041592
3negative regulation of cytosolic calcium ion concentration (GO:0051481)4.51152105
4cellular response to leptin stimulus (GO:0044320)4.47026961
5cellular ketone body metabolic process (GO:0046950)4.38940338
6positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.37316851
7L-alpha-amino acid transmembrane transport (GO:1902475)4.28208350
8cerebellar Purkinje cell layer development (GO:0021680)4.25474809
9peptide hormone processing (GO:0016486)4.25171307
10toxin metabolic process (GO:0009404)4.22469981
11vascular smooth muscle contraction (GO:0014829)4.07068929
12artery smooth muscle contraction (GO:0014824)4.02694880
13insulin secretion (GO:0030073)3.94342359
14response to dietary excess (GO:0002021)3.87431962
15ketone body metabolic process (GO:1902224)3.85107647
16cellular zinc ion homeostasis (GO:0006882)3.82877137
17epithelial cell fate commitment (GO:0072148)3.82732477
18response to leptin (GO:0044321)3.79116915
19hair cell differentiation (GO:0035315)3.74627533
20astrocyte differentiation (GO:0048708)3.70516887
21macroautophagy (GO:0016236)3.62740931
22zinc ion homeostasis (GO:0055069)3.61225235
23negative regulation of execution phase of apoptosis (GO:1900118)3.52785847
24inner ear receptor cell differentiation (GO:0060113)3.51291408
25regulation of extracellular matrix disassembly (GO:0010715)3.49631465
26tonic smooth muscle contraction (GO:0014820)3.43254418
27nodal signaling pathway (GO:0038092)3.42101746
28nonmotile primary cilium assembly (GO:0035058)3.32834712
29endocrine pancreas development (GO:0031018)3.32050170
30negative regulation of cAMP-mediated signaling (GO:0043951)3.28357706
31mechanoreceptor differentiation (GO:0042490)3.23101619
32positive regulation of insulin secretion (GO:0032024)3.18554141
33positive regulation of gluconeogenesis (GO:0045722)3.15691134
34regulation of cilium movement (GO:0003352)3.09265682
35positive regulation of oligodendrocyte differentiation (GO:0048714)3.03564720
36beta-amyloid metabolic process (GO:0050435)2.99777007
37regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.97964819
38vitamin D metabolic process (GO:0042359)2.97741955
39retinal rod cell development (GO:0046548)2.97536045
40cardiac left ventricle morphogenesis (GO:0003214)2.96794572
41toxin transport (GO:1901998)2.90842644
42amyloid precursor protein catabolic process (GO:0042987)2.87950531
43neuromuscular process controlling posture (GO:0050884)2.86616024
44brain morphogenesis (GO:0048854)2.85006575
45detection of calcium ion (GO:0005513)2.84240056
46limb development (GO:0060173)2.83604530
47appendage development (GO:0048736)2.83604530
48photoreceptor cell maintenance (GO:0045494)2.81356801
49reverse cholesterol transport (GO:0043691)2.80378374
50regulation of type B pancreatic cell apoptotic process (GO:2000674)2.77198737
51zinc ion transmembrane transport (GO:0071577)2.76955465
52phosphatidylcholine biosynthetic process (GO:0006656)2.76550802
53regulation of autophagic vacuole assembly (GO:2000785)2.76522996
54protein prenylation (GO:0018342)2.68602062
55prenylation (GO:0097354)2.68602062
56positive regulation of neurotransmitter transport (GO:0051590)2.68557190
57amino-acid betaine transport (GO:0015838)2.67193462
58carnitine transport (GO:0015879)2.67193462
59negative regulation of glycoprotein biosynthetic process (GO:0010561)2.65403373
60peptide hormone secretion (GO:0030072)2.63625120
61regulation of protein kinase C signaling (GO:0090036)2.62039896
62regulation of protein glycosylation (GO:0060049)2.61662084
63chondroitin sulfate catabolic process (GO:0030207)2.59744877
64peptide secretion (GO:0002790)2.58414644
65negative regulation of appetite (GO:0032099)2.56400104
66negative regulation of response to food (GO:0032096)2.56400104
67retinol metabolic process (GO:0042572)2.55472010
68regulation of respiratory system process (GO:0044065)2.55367703
69single strand break repair (GO:0000012)2.54846269
70positive regulation of peptide hormone secretion (GO:0090277)2.54788179
71neuron fate specification (GO:0048665)2.54330514
72regulation of neurotransmitter uptake (GO:0051580)2.52414390
73eye photoreceptor cell differentiation (GO:0001754)2.52119847
74photoreceptor cell differentiation (GO:0046530)2.52119847
75regulation of vacuole organization (GO:0044088)2.50574871
76response to auditory stimulus (GO:0010996)2.50240281
77potassium ion export (GO:0071435)2.50062626
78glucosamine-containing compound catabolic process (GO:1901072)2.49984142
79synaptic vesicle maturation (GO:0016188)2.49875598
80potassium ion homeostasis (GO:0055075)2.49768716
81vasodilation (GO:0042311)2.49415380
82branched-chain amino acid catabolic process (GO:0009083)2.47597677
83positive regulation of peptide secretion (GO:0002793)2.47539980
84ethanol oxidation (GO:0006069)2.46847372
85peptide metabolic process (GO:0006518)2.46154314
86L-phenylalanine catabolic process (GO:0006559)2.44885187
87erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.44885187
88heme transport (GO:0015886)2.42984119
89mitochondrial calcium ion homeostasis (GO:0051560)2.42836964
90renal absorption (GO:0070293)2.41682453
91glandular epithelial cell differentiation (GO:0002067)2.41269898
92neuron cell-cell adhesion (GO:0007158)2.41200163
93innervation (GO:0060384)2.40749793
94fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.40224626
95positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.39062392
96regulation of execution phase of apoptosis (GO:1900117)2.38820237
97calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.37941474
98ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.37641800
99preassembly of GPI anchor in ER membrane (GO:0016254)2.36776334
100C-terminal protein lipidation (GO:0006501)2.36619099

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.40661249
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.62860891
3GBX2_23144817_ChIP-Seq_PC3_Human3.49693105
4EZH2_22144423_ChIP-Seq_EOC_Human3.29620186
5IGF1R_20145208_ChIP-Seq_DFB_Human2.85241536
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25534146
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03528787
8CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92268955
9CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88814188
10HTT_18923047_ChIP-ChIP_STHdh_Human1.80151352
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.77366125
12TAF15_26573619_Chip-Seq_HEK293_Human1.74527006
13ZNF274_21170338_ChIP-Seq_K562_Hela1.71032763
14FLI1_27457419_Chip-Seq_LIVER_Mouse1.64690865
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64511581
16SMAD4_21799915_ChIP-Seq_A2780_Human1.61666394
17PIAS1_25552417_ChIP-Seq_VCAP_Human1.60125554
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.51159033
19REST_21632747_ChIP-Seq_MESCs_Mouse1.49249206
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.48901630
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47995148
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47869439
23P300_19829295_ChIP-Seq_ESCs_Human1.45457448
24OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44866644
25SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44413204
26STAT3_23295773_ChIP-Seq_U87_Human1.44266142
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43408985
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42644116
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42107371
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41253391
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37668132
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36621432
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.34157239
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32746534
35FUS_26573619_Chip-Seq_HEK293_Human1.32278570
36VDR_22108803_ChIP-Seq_LS180_Human1.32123342
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31400079
38BCAT_22108803_ChIP-Seq_LS180_Human1.29938452
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29638707
40CBP_20019798_ChIP-Seq_JUKART_Human1.29638707
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.27853940
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27451817
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22893045
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21183671
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20952207
46TCF4_23295773_ChIP-Seq_U87_Human1.20526972
47TP53_22573176_ChIP-Seq_HFKS_Human1.20371786
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19549697
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18715596
50TAL1_26923725_Chip-Seq_HPCs_Mouse1.17735700
51RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17663191
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13786939
53FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13328255
54ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13090142
55EED_16625203_ChIP-ChIP_MESCs_Mouse1.13030422
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12056086
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12014956
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.11758511
59FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11095993
60ER_23166858_ChIP-Seq_MCF-7_Human1.10833205
61P53_22387025_ChIP-Seq_ESCs_Mouse1.10599359
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10525152
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10229646
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09223467
65EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08638343
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08354314
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07520830
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.05975369
69AR_25329375_ChIP-Seq_VCAP_Human1.05332549
70CDX2_22108803_ChIP-Seq_LS180_Human1.05262308
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.04875493
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04875493
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04858277
74EZH2_27304074_Chip-Seq_ESCs_Mouse1.04838266
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.03990335
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.02154551
77STAT1_17558387_ChIP-Seq_HELA_Human1.02013184
78KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01664336
79TCF4_22108803_ChIP-Seq_LS180_Human1.01323238
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.01122228
81EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00986595
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.00802538
83NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00635373
84RUNX2_22187159_ChIP-Seq_PCA_Human1.00227720
85RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00003789
86NFE2_27457419_Chip-Seq_LIVER_Mouse0.99772524
87CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99707062
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99294585
89P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99148584
90SOX2_18555785_Chip-Seq_ESCs_Mouse0.99070844
91CMYC_18555785_Chip-Seq_ESCs_Mouse0.98654848
92RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96142090
93EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96142090
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96080631
95LXR_22158963_ChIP-Seq_LIVER_Mouse0.95783963
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.94387170
97E2F1_18555785_Chip-Seq_ESCs_Mouse0.94310160
98AR_20517297_ChIP-Seq_VCAP_Human0.92976915
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.92811507
100FOXA1_25552417_ChIP-Seq_VCAP_Human0.92255465

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo5.74989901
2MP0002837_dystrophic_cardiac_calcinosis3.96467820
3MP0005379_endocrine/exocrine_gland_phen3.66816897
4MP0002139_abnormal_hepatobiliary_system3.64129169
5MP0002909_abnormal_adrenal_gland3.49422368
6MP0005645_abnormal_hypothalamus_physiol3.17582482
7MP0000013_abnormal_adipose_tissue3.16798273
8MP0004019_abnormal_vitamin_homeostasis3.06308388
9MP0002254_reproductive_system_inflammat2.86946696
10MP0003879_abnormal_hair_cell2.32506940
11MP0003787_abnormal_imprinting2.32221153
12MP0002163_abnormal_gland_morphology2.28515341
13MP0003011_delayed_dark_adaptation2.16024111
14MP0001984_abnormal_olfaction2.14803208
15MP0004270_analgesia2.02358540
16MP0001944_abnormal_pancreas_morphology2.00199167
17MP0010329_abnormal_lipoprotein_level1.91897381
18MP0005174_abnormal_tail_pigmentation1.82313089
19MP0003136_yellow_coat_color1.74089735
20MP0005646_abnormal_pituitary_gland1.70635166
21MP0005167_abnormal_blood-brain_barrier1.68284476
22MP0002693_abnormal_pancreas_physiology1.67308935
23MP0001756_abnormal_urination1.66481155
24MP0005332_abnormal_amino_acid1.66379970
25MP0005551_abnormal_eye_electrophysiolog1.65303844
26MP0002876_abnormal_thyroid_physiology1.61393957
27MP0005636_abnormal_mineral_homeostasis1.58930560
28MP0003122_maternal_imprinting1.56441859
29MP0001986_abnormal_taste_sensitivity1.55312211
30MP0006072_abnormal_retinal_apoptosis1.53009612
31MP0002734_abnormal_mechanical_nocicepti1.49890526
32MP0003172_abnormal_lysosome_physiology1.49720434
33MP0009046_muscle_twitch1.48923437
34MP0002064_seizures1.47368772
35MP0002272_abnormal_nervous_system1.47360132
36MP0001485_abnormal_pinna_reflex1.46262501
37MP0003633_abnormal_nervous_system1.43773077
38MP0000631_abnormal_neuroendocrine_gland1.42745717
39MP0004885_abnormal_endolymph1.42439829
40MP0001765_abnormal_ion_homeostasis1.37661431
41MP0005248_abnormal_Harderian_gland1.36485849
42MP0001502_abnormal_circadian_rhythm1.36423707
43MP0000003_abnormal_adipose_tissue1.34930937
44MP0001970_abnormal_pain_threshold1.33044900
45MP0005058_abnormal_lysosome_morphology1.32087985
46MP0002638_abnormal_pupillary_reflex1.30252658
47MP0009745_abnormal_behavioral_response1.30087523
48MP0006054_spinal_hemorrhage1.28073432
49MP0005670_abnormal_white_adipose1.27456477
50MP0005253_abnormal_eye_physiology1.27148006
51MP0003690_abnormal_glial_cell1.23327568
52MP0000372_irregular_coat_pigmentation1.21225280
53MP0000639_abnormal_adrenal_gland1.20635599
54MP0003868_abnormal_feces_composition1.19855721
55MP0002078_abnormal_glucose_homeostasis1.18619325
56MP0002572_abnormal_emotion/affect_behav1.18513321
57MP0002090_abnormal_vision1.17202059
58MP0001486_abnormal_startle_reflex1.16745928
59MP0002733_abnormal_thermal_nociception1.14688686
60MP0003121_genomic_imprinting1.10822954
61MP0004133_heterotaxia1.10175105
62MP0002938_white_spotting1.05960468
63MP0009840_abnormal_foam_cell1.05757679
64MP0001968_abnormal_touch/_nociception1.05249668
65MP0003953_abnormal_hormone_level1.03619369
66MP0001664_abnormal_digestion1.02804542
67MP0005535_abnormal_body_temperature1.02752409
68MP0001529_abnormal_vocalization0.99690355
69MP0001501_abnormal_sleep_pattern0.98929598
70MP0005448_abnormal_energy_balance0.97080413
71MP0003634_abnormal_glial_cell0.96555430
72MP0002557_abnormal_social/conspecific_i0.95711701
73MP0002118_abnormal_lipid_homeostasis0.95000566
74MP0004142_abnormal_muscle_tone0.94454826
75MP0003631_nervous_system_phenotype0.93216972
76MP0005365_abnormal_bile_salt0.91416211
77MP0002138_abnormal_hepatobiliary_system0.87196801
78MP0008877_abnormal_DNA_methylation0.85439745
79MP0002653_abnormal_ependyma_morphology0.85306695
80MP0002063_abnormal_learning/memory/cond0.84990186
81MP0004085_abnormal_heartbeat0.82961141
82MP0002229_neurodegeneration0.79183299
83MP0001963_abnormal_hearing_physiology0.76318909
84MP0002127_abnormal_cardiovascular_syste0.76187058
85MP0004924_abnormal_behavior0.75947103
86MP0005386_behavior/neurological_phenoty0.75947103
87MP0003632_abnormal_nervous_system0.74446426
88MP0003635_abnormal_synaptic_transmissio0.72937232
89MP0003183_abnormal_peptide_metabolism0.71397296
90MP0005084_abnormal_gallbladder_morpholo0.70727695
91MP0004215_abnormal_myocardial_fiber0.69545719
92MP0001764_abnormal_homeostasis0.69087098
93MP0002295_abnormal_pulmonary_circulatio0.68496516
94MP0005220_abnormal_exocrine_pancreas0.67813394
95MP0000230_abnormal_systemic_arterial0.67736267
96MP0000920_abnormal_myelination0.67032126
97MP0002069_abnormal_eating/drinking_beha0.65670112
98MP0000026_abnormal_inner_ear0.64954836
99MP0001270_distended_abdomen0.64867180
100MP0004147_increased_porphyrin_level0.64344821

Predicted human phenotypes

RankGene SetZ-score
1Polyphagia (HP:0002591)4.10898506
2Hyperglycemia (HP:0003074)3.79286730
3Hemiparesis (HP:0001269)3.77506400
4Congenital malformation of the right heart (HP:0011723)3.62827234
5Double outlet right ventricle (HP:0001719)3.62827234
6Congenital sensorineural hearing impairment (HP:0008527)3.61805430
7Ketoacidosis (HP:0001993)3.53928437
8Increased CSF protein (HP:0002922)3.31492867
9Hypoglycemic coma (HP:0001325)3.30014161
10Large for gestational age (HP:0001520)3.20518987
11Intestinal atresia (HP:0011100)3.17341402
12Medial flaring of the eyebrow (HP:0010747)3.16187304
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.09334749
14Abnormality of alanine metabolism (HP:0010916)3.05527017
15Hyperalaninemia (HP:0003348)3.05527017
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.05527017
17Proximal tubulopathy (HP:0000114)2.98569633
18Hypoglycemic seizures (HP:0002173)2.78417072
19Abnormality of polysaccharide metabolism (HP:0011012)2.77513496
20Abnormality of glycosaminoglycan metabolism (HP:0004371)2.77513496
21Abnormality of mucopolysaccharide metabolism (HP:0011020)2.77513496
22Abnormality of vitamin B metabolism (HP:0004340)2.75422084
23Mucopolysacchariduria (HP:0008155)2.74780991
24Urinary glycosaminoglycan excretion (HP:0003541)2.74780991
25Constricted visual fields (HP:0001133)2.74718726
26Late onset (HP:0003584)2.74694749
27Abnormal eating behavior (HP:0100738)2.73168532
28Hyperinsulinemic hypoglycemia (HP:0000825)2.72949241
29Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.72868449
30Joint hemorrhage (HP:0005261)2.60986696
31Ketosis (HP:0001946)2.60972462
32Progressive neurologic deterioration (HP:0002344)2.52438042
33Abnormality of vitamin metabolism (HP:0100508)2.47478236
34Agitation (HP:0000713)2.46502771
35Type II lissencephaly (HP:0007260)2.44771012
36Prolonged partial thromboplastin time (HP:0003645)2.44660170
37Intention tremor (HP:0002080)2.43078024
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.42409630
393-Methylglutaconic aciduria (HP:0003535)2.42063395
40Hyperglycinemia (HP:0002154)2.40821261
41Cardiomegaly (HP:0001640)2.38486379
42Abnormality of binocular vision (HP:0011514)2.33691449
43Diplopia (HP:0000651)2.33691449
44Prominent supraorbital ridges (HP:0000336)2.33353020
45Fetal akinesia sequence (HP:0001989)2.29755491
46Glycosuria (HP:0003076)2.27508062
47Abnormality of urine glucose concentration (HP:0011016)2.27508062
48Hyperphosphatemia (HP:0002905)2.23356770
49Pheochromocytoma (HP:0002666)2.23053759
50Absent speech (HP:0001344)2.21527797
51J-shaped sella turcica (HP:0002680)2.20565183
52Septate vagina (HP:0001153)2.16489599
53Anxiety (HP:0000739)2.16430368
54Gait imbalance (HP:0002141)2.15827200
55Pancreatic fibrosis (HP:0100732)2.14868191
56Growth hormone excess (HP:0000845)2.12724917
57Limb hypertonia (HP:0002509)2.12371638
58Methylmalonic acidemia (HP:0002912)2.12276498
59Vascular calcification (HP:0004934)2.11803450
60Gingival bleeding (HP:0000225)2.11791604
61Abolished electroretinogram (ERG) (HP:0000550)2.09982344
62Abnormality of glycolipid metabolism (HP:0010969)2.08152002
63Abnormality of liposaccharide metabolism (HP:0010968)2.08152002
64Abnormality of glycosphingolipid metabolism (HP:0004343)2.08152002
65Congenital primary aphakia (HP:0007707)2.07816654
66Hyperlipoproteinemia (HP:0010980)2.05390476
67Attenuation of retinal blood vessels (HP:0007843)2.02178504
68Neuroendocrine neoplasm (HP:0100634)2.00912904
69Hypokinesia (HP:0002375)1.97342743
70True hermaphroditism (HP:0010459)1.94268656
71Anteriorly placed anus (HP:0001545)1.93939673
72Hyperventilation (HP:0002883)1.93605519
73Resting tremor (HP:0002322)1.92357815
74Diminished movement (HP:0002374)1.91992824
75Abnormality of serine family amino acid metabolism (HP:0010894)1.91876969
76Abnormality of glycine metabolism (HP:0010895)1.91876969
77Neoplasm of the heart (HP:0100544)1.91764515
78Abnormality of calcium-phosphate metabolism (HP:0100530)1.91326946
79Prolonged QT interval (HP:0001657)1.91264499
80Pancreatic cysts (HP:0001737)1.91051265
81Tubular atrophy (HP:0000092)1.90713736
82Poor suck (HP:0002033)1.90231811
83Abnormality of fatty-acid metabolism (HP:0004359)1.90141576
84Delayed CNS myelination (HP:0002188)1.87671798
85Aplasia/Hypoplasia of the fovea (HP:0008060)1.87305332
86Hypoplasia of the fovea (HP:0007750)1.87305332
87Nephronophthisis (HP:0000090)1.80765588
88Cerebellar dysplasia (HP:0007033)1.79804038
89Abnormality of renal excretion (HP:0011036)1.79569399
90Renal cortical cysts (HP:0000803)1.77385057
91Abnormality of the common coagulation pathway (HP:0010990)1.75802795
92Truncus arteriosus (HP:0001660)1.74738300
93Insulin-resistant diabetes mellitus (HP:0000831)1.74295025
94Occipital encephalocele (HP:0002085)1.73669194
95Sensorimotor neuropathy (HP:0007141)1.73570431
96Hyperammonemia (HP:0001987)1.73258309
97Atrioventricular canal defect (HP:0006695)1.73079953
98Cardiovascular calcification (HP:0011915)1.72824225
99Unilateral renal agenesis (HP:0000122)1.72759803
100Gaze-evoked nystagmus (HP:0000640)1.72597418

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.81737536
2WNK34.57479692
3LATS14.37072325
4PRKD34.06410451
5DAPK23.36794208
6FRK2.83179579
7MAP3K92.73933780
8UHMK12.62492666
9CASK2.23159811
10PINK12.18992067
11NTRK32.06520620
12ARAF1.97789501
13MAP2K61.80549401
14PHKG21.73907364
15PHKG11.73907364
16TRPM71.68113494
17STK31.65061230
18TNK21.52331651
19PAK31.51430697
20TRIM281.48973150
21MAPK131.46794571
22PAK61.42907577
23NUAK11.41176165
24CAMK2D1.40139872
25MAP3K131.36041136
26GRK11.34619239
27BCKDK1.31329368
28MET1.28259046
29ACVR1B1.25139505
30KSR21.24227391
31BMPR1B1.17716787
32NTRK21.15823947
33STK241.13687514
34EPHB11.06274403
35ADRBK21.04971885
36TAOK31.03505051
37PTK2B0.95932987
38MST40.95398114
39TIE10.91910139
40PRKCE0.85656827
41DYRK1B0.84177802
42PDK20.82594842
43CDC42BPA0.82525874
44MOS0.80373671
45CSNK1G30.77924050
46MYLK0.72448765
47TNIK0.67473613
48RAF10.67431317
49PRKD20.66779891
50EPHA40.66556077
51CSNK1A1L0.65467583
52EPHA30.65205561
53CSNK1G10.63349872
54FER0.63167253
55FGFR20.61697969
56STK38L0.61486585
57CAMK2G0.60239172
58WNK40.60194779
59CSNK1G20.58734212
60CAMK2A0.58534462
61TAOK10.57980913
62PRKCG0.57576801
63DAPK10.55533685
64STK40.54427358
65PDGFRB0.53594285
66MARK10.53248479
67CDK30.52281729
68MAPK150.50114271
69INSRR0.47718910
70STK160.47717866
71KSR10.47694419
72MAP3K40.47067976
73ROCK20.44487556
74FGFR40.43241969
75BMX0.41342639
76PRKCH0.40969788
77NLK0.40712853
78MAP2K10.40001469
79CAMK10.39144239
80GSK3A0.37997125
81CDK50.37648206
82YES10.37071613
83STK390.36739512
84ERBB20.36099477
85TGFBR10.35393423
86ROCK10.34872873
87CSNK1A10.34694602
88DAPK30.34668060
89CAMK2B0.34575495
90PDPK10.34079844
91PRKAA20.33684278
92PRKAA10.33558492
93RPS6KA20.33136345
94PRKG10.32976234
95TYRO30.32431108
96FGFR30.31834750
97CAMK1D0.31544182
98PRKACA0.30302339
99OBSCN0.29077390
100PDK10.28678799

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.48204019
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.76362263
3Insulin secretion_Homo sapiens_hsa049112.60254547
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.42628645
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.40233317
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.37842891
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.18770834
8Selenocompound metabolism_Homo sapiens_hsa004502.15185965
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.10334653
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.99926470
11Butanoate metabolism_Homo sapiens_hsa006501.98907878
12Sulfur metabolism_Homo sapiens_hsa009201.94188222
13Folate biosynthesis_Homo sapiens_hsa007901.91721407
14Fatty acid elongation_Homo sapiens_hsa000621.85979470
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.70847240
16Fatty acid metabolism_Homo sapiens_hsa012121.66133822
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.65639666
18Tryptophan metabolism_Homo sapiens_hsa003801.52167268
19Peroxisome_Homo sapiens_hsa041461.49653453
20Collecting duct acid secretion_Homo sapiens_hsa049661.48360872
21Renin secretion_Homo sapiens_hsa049241.47610837
22Circadian entrainment_Homo sapiens_hsa047131.42497373
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.42027908
24Fatty acid degradation_Homo sapiens_hsa000711.41832920
25Sphingolipid metabolism_Homo sapiens_hsa006001.39066641
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.33045017
27Propanoate metabolism_Homo sapiens_hsa006401.33044960
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32092722
29GABAergic synapse_Homo sapiens_hsa047271.31427952
30Dopaminergic synapse_Homo sapiens_hsa047281.25417869
31Ether lipid metabolism_Homo sapiens_hsa005651.23112225
32Morphine addiction_Homo sapiens_hsa050321.20757945
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19388310
34Histidine metabolism_Homo sapiens_hsa003401.12724213
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05582608
36Amphetamine addiction_Homo sapiens_hsa050311.03714099
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01217848
38Glutamatergic synapse_Homo sapiens_hsa047241.00756595
39Arginine and proline metabolism_Homo sapiens_hsa003301.00716509
40Lysosome_Homo sapiens_hsa041421.00687543
41Olfactory transduction_Homo sapiens_hsa047401.00495671
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00288658
43Other glycan degradation_Homo sapiens_hsa005110.99304940
44Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96687484
45Cocaine addiction_Homo sapiens_hsa050300.96653666
46Mineral absorption_Homo sapiens_hsa049780.95840010
47Nitrogen metabolism_Homo sapiens_hsa009100.95591323
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94950564
49Gastric acid secretion_Homo sapiens_hsa049710.94296559
50Retinol metabolism_Homo sapiens_hsa008300.93793342
51ABC transporters_Homo sapiens_hsa020100.92917401
52Serotonergic synapse_Homo sapiens_hsa047260.92319731
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91839177
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91449737
55Long-term depression_Homo sapiens_hsa047300.90611119
56Bile secretion_Homo sapiens_hsa049760.89032646
57beta-Alanine metabolism_Homo sapiens_hsa004100.88091697
58Synaptic vesicle cycle_Homo sapiens_hsa047210.85960710
59Glucagon signaling pathway_Homo sapiens_hsa049220.85596311
60Thyroid hormone synthesis_Homo sapiens_hsa049180.85265650
61Salivary secretion_Homo sapiens_hsa049700.84817670
62Glutathione metabolism_Homo sapiens_hsa004800.84060622
63Oxidative phosphorylation_Homo sapiens_hsa001900.81225548
64cAMP signaling pathway_Homo sapiens_hsa040240.80803337
65Vibrio cholerae infection_Homo sapiens_hsa051100.80736596
66Ovarian steroidogenesis_Homo sapiens_hsa049130.79858208
67PPAR signaling pathway_Homo sapiens_hsa033200.79088253
68Type I diabetes mellitus_Homo sapiens_hsa049400.78218173
69Complement and coagulation cascades_Homo sapiens_hsa046100.77098233
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75136015
71Arginine biosynthesis_Homo sapiens_hsa002200.71209949
72Nicotine addiction_Homo sapiens_hsa050330.69950747
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69537542
74Arachidonic acid metabolism_Homo sapiens_hsa005900.68949072
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67974439
76Protein export_Homo sapiens_hsa030600.66790188
77Phototransduction_Homo sapiens_hsa047440.66609785
78Circadian rhythm_Homo sapiens_hsa047100.63360456
79Linoleic acid metabolism_Homo sapiens_hsa005910.60295990
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.59291428
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59031535
82Cardiac muscle contraction_Homo sapiens_hsa042600.57747983
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57612997
84Chemical carcinogenesis_Homo sapiens_hsa052040.57369473
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56512337
86Taste transduction_Homo sapiens_hsa047420.54077426
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.52327779
88Metabolic pathways_Homo sapiens_hsa011000.51548264
89Cholinergic synapse_Homo sapiens_hsa047250.50196388
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50119410
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49347235
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48302472
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47530073
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44913813
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44812196
96Dorso-ventral axis formation_Homo sapiens_hsa043200.42541309
97Vitamin digestion and absorption_Homo sapiens_hsa049770.41882801
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.40455960
99Renin-angiotensin system_Homo sapiens_hsa046140.40252696
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38588794

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