CYP4F2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.31722700
2drug catabolic process (GO:0042737)8.72652746
3* epoxygenase P450 pathway (GO:0019373)8.67709285
4cellular glucuronidation (GO:0052695)6.75386373
5urea metabolic process (GO:0019627)6.70434549
6regulation of fibrinolysis (GO:0051917)6.69406096
7* drug metabolic process (GO:0017144)6.60102864
8* omega-hydroxylase P450 pathway (GO:0097267)6.60048015
9negative regulation of fibrinolysis (GO:0051918)6.56862593
10glucuronate metabolic process (GO:0019585)6.46676543
11uronic acid metabolic process (GO:0006063)6.46676543
12glyoxylate metabolic process (GO:0046487)6.36373449
13regulation of triglyceride catabolic process (GO:0010896)6.29650816
14complement activation, alternative pathway (GO:0006957)6.21153468
15ethanol oxidation (GO:0006069)6.15982558
16nitrogen cycle metabolic process (GO:0071941)6.10490511
17regulation of protein activation cascade (GO:2000257)5.96034045
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.94288600
19L-phenylalanine catabolic process (GO:0006559)5.94288600
20urea cycle (GO:0000050)5.85516142
21regulation of complement activation (GO:0030449)5.63959714
22L-phenylalanine metabolic process (GO:0006558)5.52724630
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.52724630
24bile acid and bile salt transport (GO:0015721)5.43871740
25bile acid metabolic process (GO:0008206)5.41966719
26oxidative demethylation (GO:0070989)5.40076398
27hormone catabolic process (GO:0042447)5.36295079
28negative regulation of sterol transport (GO:0032372)5.35303171
29negative regulation of cholesterol transport (GO:0032375)5.35303171
30fibrinolysis (GO:0042730)5.31146221
31phospholipid efflux (GO:0033700)5.22910682
32triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.21915576
33protein carboxylation (GO:0018214)5.11987452
34peptidyl-glutamic acid carboxylation (GO:0017187)5.11987452
35phenylpropanoid metabolic process (GO:0009698)5.02050136
36bile acid biosynthetic process (GO:0006699)5.00991883
37ethanol metabolic process (GO:0006067)4.94178254
38alkaloid metabolic process (GO:0009820)4.93939233
39very-low-density lipoprotein particle assembly (GO:0034379)4.92475339
40angiotensin maturation (GO:0002003)4.71734606
41regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.70364062
42blood coagulation, intrinsic pathway (GO:0007597)4.68155584
43positive regulation of triglyceride lipase activity (GO:0061365)4.62400046
44positive regulation of lipoprotein lipase activity (GO:0051006)4.62400046
45regulation of cholesterol esterification (GO:0010872)4.62362242
46high-density lipoprotein particle remodeling (GO:0034375)4.57602315
47flavonoid metabolic process (GO:0009812)4.47259507
48cholesterol efflux (GO:0033344)4.45358668
49regulation of bile acid biosynthetic process (GO:0070857)4.43375964
50* fat-soluble vitamin biosynthetic process (GO:0042362)4.40406252
51aromatic amino acid family catabolic process (GO:0009074)4.40401355
52plasma lipoprotein particle remodeling (GO:0034369)4.39786087
53protein-lipid complex remodeling (GO:0034368)4.39786087
54macromolecular complex remodeling (GO:0034367)4.39786087
55triglyceride homeostasis (GO:0070328)4.22956378
56acylglycerol homeostasis (GO:0055090)4.22956378
57intestinal absorption (GO:0050892)4.20749692
58serine family amino acid catabolic process (GO:0009071)4.19942222
59plasma lipoprotein particle assembly (GO:0034377)4.19694743
60fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.17758150
61regulation of plasminogen activation (GO:0010755)4.14945399
62heme transport (GO:0015886)4.13636695
63* negative regulation of blood coagulation (GO:0030195)4.12145559
64* negative regulation of hemostasis (GO:1900047)4.12145559
65protein activation cascade (GO:0072376)4.09122552
66fructose metabolic process (GO:0006000)4.06526292
67reverse cholesterol transport (GO:0043691)4.05833018
68amino-acid betaine metabolic process (GO:0006577)4.03677839
69arginine metabolic process (GO:0006525)3.97718363
70intestinal cholesterol absorption (GO:0030299)3.92035476
71complement activation, classical pathway (GO:0006958)3.91923757
72positive regulation of lipid catabolic process (GO:0050996)3.89882866
73lipoprotein transport (GO:0042953)3.89228825
74complement activation (GO:0006956)3.85638324
75NADH metabolic process (GO:0006734)3.85507116
76acute-phase response (GO:0006953)3.83818811
77glycine metabolic process (GO:0006544)3.81601737
78protein-lipid complex assembly (GO:0065005)3.75723865
79* negative regulation of coagulation (GO:0050819)3.75401714
80lipoprotein metabolic process (GO:0042157)3.70142117
81drug transmembrane transport (GO:0006855)3.69085259
82negative regulation of lipase activity (GO:0060192)3.68295987
83* negative regulation of wound healing (GO:0061045)3.65790251
84plasma lipoprotein particle organization (GO:0071827)3.60744104
85glutamate metabolic process (GO:0006536)3.59247760
86regulation of humoral immune response (GO:0002920)3.57103979
87drug transport (GO:0015893)3.55900457
88S-adenosylmethionine metabolic process (GO:0046500)3.55535243
89* xenobiotic metabolic process (GO:0006805)3.53635138
90imidazole-containing compound metabolic process (GO:0052803)3.52733703
91cholesterol homeostasis (GO:0042632)3.48343808
92positive regulation of fatty acid biosynthetic process (GO:0045723)3.44011213
93sterol homeostasis (GO:0055092)3.42339366
94oxaloacetate metabolic process (GO:0006107)3.40592979
95protein-lipid complex subunit organization (GO:0071825)3.40332755
96positive regulation of hemostasis (GO:1900048)3.36086763
97positive regulation of blood coagulation (GO:0030194)3.36086763
98primary alcohol catabolic process (GO:0034310)3.35554857
99tyrosine metabolic process (GO:0006570)3.33678299
100negative regulation of protein activation cascade (GO:2000258)3.33386995

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.68320070
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.09295283
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.74618838
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.20318272
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.08451628
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.35361636
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.15648754
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.42658793
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.24788354
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.92526637
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.87344619
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.71893888
13HNF4A_19822575_ChIP-Seq_HepG2_Human2.14144506
14FOXA2_19822575_ChIP-Seq_HepG2_Human2.02915129
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97267646
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.89717825
17GATA4_25053715_ChIP-Seq_YYC3_Human1.78010428
18GATA1_22025678_ChIP-Seq_K562_Human1.68627105
19SOX2_27498859_Chip-Seq_STOMACH_Mouse1.65835726
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.61340284
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58284942
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.56902717
23BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56680886
24AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.45386541
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.44470632
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42416124
27* GATA6_25053715_ChIP-Seq_YYC3_Human1.42206412
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35952180
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30740430
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30386711
31HTT_18923047_ChIP-ChIP_STHdh_Human1.25817315
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21511233
33SOX2_20726797_ChIP-Seq_SW620_Human1.15730998
34FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14446479
35PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13109712
36LXR_22292898_ChIP-Seq_THP-1_Human1.10995071
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08835013
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.05410996
39CLOCK_20551151_ChIP-Seq_293T_Human1.04823120
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01534844
41FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00450643
42FOXA1_25552417_ChIP-Seq_VCAP_Human0.98886296
43NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97773640
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97487551
45FOXO3_23340844_ChIP-Seq_DLD1_Human0.93389660
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91741725
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91149198
48ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90220574
49* CEBPB_22108803_ChIP-Seq_LS180_Human0.89248543
50TCF4_18268006_ChIP-ChIP_LS174T_Human0.87066389
51RXRA_24833708_ChIP-Seq_LIVER_Mouse0.86769150
52KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86052395
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85425470
54CBP_21632823_ChIP-Seq_H3396_Human0.84901100
55CDX2_22108803_ChIP-Seq_LS180_Human0.84559999
56ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84222913
57ESR2_21235772_ChIP-Seq_MCF-7_Human0.83593270
58BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.83475734
59PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79514459
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79087315
61HNFA_21074721_ChIP-Seq_CACO-2_Human0.76436004
62SOX2_21211035_ChIP-Seq_LN229_Human0.73933855
63AR_20517297_ChIP-Seq_VCAP_Human0.71435943
64BCAT_22108803_ChIP-Seq_LS180_Human0.71369755
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70492587
66SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70359907
67SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69474942
68CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.69438079
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.69105447
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.69082826
71DNAJC2_21179169_ChIP-ChIP_NT2_Human0.68511338
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.68493530
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67507045
74JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.67440402
75BCOR_27268052_Chip-Seq_Bcells_Human0.66322502
76RARG_19884340_ChIP-ChIP_MEFs_Mouse0.65462370
77CTCF_27219007_Chip-Seq_Bcells_Human0.65141646
78EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.64276032
79BCL6_27268052_Chip-Seq_Bcells_Human0.63390963
80* SA1_27219007_Chip-Seq_Bcells_Human0.63311686
81NANOG_20526341_ChIP-Seq_ESCs_Human0.63271151
82ETV2_25802403_ChIP-Seq_MESCs_Mouse0.63207787
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62861931
84RAC3_21632823_ChIP-Seq_H3396_Human0.62446389
85PHF8_20622853_ChIP-Seq_HELA_Human0.61666560
86GATA2_19941826_ChIP-Seq_K562_Human0.61529603
87SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.61255141
88P53_21459846_ChIP-Seq_SAOS-2_Human0.61229298
89RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60674302
90SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.60351767
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.60078773
92TAF2_19829295_ChIP-Seq_ESCs_Human0.59822539
93GATA1_19941826_ChIP-Seq_K562_Human0.59470899
94NFYA_21822215_ChIP-Seq_K562_Human0.59083046
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.58846430
96GATA1_19941827_ChIP-Seq_MEL_Mouse0.58716031
97P63_26484246_Chip-Seq_KERATINOCYTES_Human0.58166206
98GATA3_24758297_ChIP-Seq_MCF-7_Human0.57650531
99SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.57390727
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.56975372

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.84089449
2MP0005360_urolithiasis8.18847481
3MP0005085_abnormal_gallbladder_physiolo6.34969417
4MP0005365_abnormal_bile_salt5.68826150
5MP0001666_abnormal_nutrient_absorption4.37588762
6MP0008875_abnormal_xenobiotic_pharmacok4.34418313
7MP0003252_abnormal_bile_duct3.60312410
8MP0003195_calcinosis3.52694047
9MP0009840_abnormal_foam_cell3.36831935
10MP0002138_abnormal_hepatobiliary_system3.13001355
11MP0003868_abnormal_feces_composition3.04479041
12MP0010329_abnormal_lipoprotein_level3.00994563
13MP0004019_abnormal_vitamin_homeostasis2.49308971
14MP0005332_abnormal_amino_acid2.47639835
15MP0003806_abnormal_nucleotide_metabolis2.09984606
16MP0003191_abnormal_cellular_cholesterol1.97589943
17MP0003183_abnormal_peptide_metabolism1.96631274
18MP0009697_abnormal_copulation1.90522969
19MP0002876_abnormal_thyroid_physiology1.85273223
20MP0000609_abnormal_liver_physiology1.78927550
21MP0002118_abnormal_lipid_homeostasis1.74799980
22MP0001764_abnormal_homeostasis1.73616883
23MP0005670_abnormal_white_adipose1.62148107
24MP0009643_abnormal_urine_homeostasis1.47782507
25MP0004264_abnormal_extraembryonic_tissu1.31528172
26MP0005319_abnormal_enzyme/_coenzyme1.14605651
27MP0005451_abnormal_body_composition1.13996063
28MP0004147_increased_porphyrin_level1.13029137
29MP0005584_abnormal_enzyme/coenzyme_acti1.11641009
30MP0005636_abnormal_mineral_homeostasis1.08235803
31MP0003879_abnormal_hair_cell1.07041708
32MP0002971_abnormal_brown_adipose1.06260518
33MP0010155_abnormal_intestine_physiology0.92852701
34MP0010368_abnormal_lymphatic_system0.91817512
35MP0009642_abnormal_blood_homeostasis0.90779660
36MP0009764_decreased_sensitivity_to0.89092712
37MP0000598_abnormal_liver_morphology0.87969950
38MP0005409_darkened_coat_color0.87589788
39MP0008469_abnormal_protein_level0.87569429
40MP0005535_abnormal_body_temperature0.84377814
41MP0005408_hypopigmentation0.82908264
42MP0003718_maternal_effect0.78510201
43MP0005166_decreased_susceptibility_to0.77467152
44MP0005376_homeostasis/metabolism_phenot0.74558188
45MP0002136_abnormal_kidney_physiology0.72482820
46MP0009379_abnormal_foot_pigmentation0.72369182
47MP0002132_abnormal_respiratory_system0.71997550
48MP0005448_abnormal_energy_balance0.69844041
49MP0000604_amyloidosis0.68892313
50MP0003656_abnormal_erythrocyte_physiolo0.68763639
51MP0009763_increased_sensitivity_to0.67961380
52MP0005334_abnormal_fat_pad0.66481747
53MP0008872_abnormal_physiological_respon0.65247785
54MP0005395_other_phenotype0.64755737
55MP0002078_abnormal_glucose_homeostasis0.64307202
56MP0010234_abnormal_vibrissa_follicle0.64166740
57MP0003638_abnormal_response/metabolism_0.63276305
58MP0009785_altered_susceptibility_to0.59627357
59MP0000566_synostosis0.58929696
60MP0009115_abnormal_fat_cell0.58831127
61MP0005058_abnormal_lysosome_morphology0.58115655
62MP0001756_abnormal_urination0.53673926
63MP0001664_abnormal_digestion0.52374899
64MP0000249_abnormal_blood_vessel0.51445233
65MP0001661_extended_life_span0.50316399
66MP0009053_abnormal_anal_canal0.50014088
67MP0000678_abnormal_parathyroid_gland0.49504052
68MP0000538_abnormal_urinary_bladder0.48982190
69MP0001765_abnormal_ion_homeostasis0.48458367
70MP0002249_abnormal_larynx_morphology0.47757184
71MP0004782_abnormal_surfactant_physiolog0.47489318
72MP0003866_abnormal_defecation0.46451241
73MP0001845_abnormal_inflammatory_respons0.45373598
74MP0005266_abnormal_metabolism0.43846338
75MP0005464_abnormal_platelet_physiology0.43454115
76MP0004043_abnormal_pH_regulation0.43075779
77MP0005666_abnormal_adipose_tissue0.42770195
78MP0009765_abnormal_xenobiotic_induced0.41269953
79MP0003011_delayed_dark_adaptation0.41262963
80MP0003953_abnormal_hormone_level0.39886896
81MP0008874_decreased_physiological_sensi0.38983941
82MP0000477_abnormal_intestine_morphology0.37961780
83MP0005023_abnormal_wound_healing0.34375221
84MP0003436_decreased_susceptibility_to0.33939060
85MP0002822_catalepsy0.31897986
86MP0003690_abnormal_glial_cell0.31451947
87MP0002168_other_aberrant_phenotype0.31202781
88MP0001663_abnormal_digestive_system0.29969604
89MP0003186_abnormal_redox_activity0.29668139
90MP0000230_abnormal_systemic_arterial0.28825446
91MP0006036_abnormal_mitochondrial_physio0.27751595
92MP0001915_intracranial_hemorrhage0.27396270
93MP0001881_abnormal_mammary_gland0.26442836
94MP0009333_abnormal_splenocyte_physiolog0.25555796
95MP0003075_altered_response_to0.25148600
96MP0005164_abnormal_response_to0.24647729
97MP0002970_abnormal_white_adipose0.24230482
98MP0004883_abnormal_blood_vessel0.24219775
99MP0002135_abnormal_kidney_morphology0.23291192
100MP0005025_abnormal_response_to0.22741076

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)8.70957019
2Hypobetalipoproteinemia (HP:0003563)8.35216127
3Deep venous thrombosis (HP:0002625)7.75903293
4Complement deficiency (HP:0004431)7.41286062
5Abnormality of glutamine family amino acid metabolism (HP:0010902)6.93246904
6Prolonged partial thromboplastin time (HP:0003645)6.86661744
7Abnormality of aromatic amino acid family metabolism (HP:0004338)6.16535752
8Abnormality of complement system (HP:0005339)6.10976337
9Conjugated hyperbilirubinemia (HP:0002908)5.82227650
10Systemic lupus erythematosus (HP:0002725)5.80719057
11Xanthomatosis (HP:0000991)5.32616744
12Joint hemorrhage (HP:0005261)4.81375564
13Hypolipoproteinemia (HP:0010981)4.65485957
14Hyperlipoproteinemia (HP:0010980)4.64504676
15Fat malabsorption (HP:0002630)4.46506053
16Intrahepatic cholestasis (HP:0001406)4.43855796
17Abnormality of proline metabolism (HP:0010907)4.41974110
18Hydroxyprolinuria (HP:0003080)4.41974110
19Glomerulonephritis (HP:0000099)4.24285868
20Abnormality of pyrimidine metabolism (HP:0004353)4.01501081
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.88399030
22Hyperglycinuria (HP:0003108)3.85820266
23Abnormality of glycine metabolism (HP:0010895)3.77818435
24Abnormality of serine family amino acid metabolism (HP:0010894)3.77818435
25Abnormality of the common coagulation pathway (HP:0010990)3.76185182
26Recurrent gram-negative bacterial infections (HP:0005420)3.44333625
27Hyperammonemia (HP:0001987)3.42571855
28Malnutrition (HP:0004395)3.35290752
29Steatorrhea (HP:0002570)3.30545417
30Abnormality of vitamin metabolism (HP:0100508)3.28127327
31Nephritis (HP:0000123)3.27807824
32Hemorrhage of the eye (HP:0011885)3.13564247
33Spontaneous abortion (HP:0005268)3.10139203
34Abnormality of the intrinsic pathway (HP:0010989)3.08067106
35Abnormality of urine glucose concentration (HP:0011016)3.05546668
36Glycosuria (HP:0003076)3.05546668
37Rickets (HP:0002748)3.04236174
38Abnormality of nucleobase metabolism (HP:0010932)3.00739261
39Abnormality of aspartate family amino acid metabolism (HP:0010899)2.99552621
40Generalized aminoaciduria (HP:0002909)2.98649863
41Epidermoid cyst (HP:0200040)2.95253016
42Hyperglycinemia (HP:0002154)2.93806485
43Acanthocytosis (HP:0001927)2.93659021
44Hypercholesterolemia (HP:0003124)2.86679635
45Delayed CNS myelination (HP:0002188)2.79936235
46Hyperphosphaturia (HP:0003109)2.72025550
47Widely patent fontanelles and sutures (HP:0004492)2.69959127
48Osteomalacia (HP:0002749)2.68307306
49Vascular calcification (HP:0004934)2.68235340
50Abnormality of purine metabolism (HP:0004352)2.54556760
51Abnormality of sulfur amino acid metabolism (HP:0004339)2.50808133
52Abnormal urine phosphate concentration (HP:0012599)2.48660687
53Hyperbilirubinemia (HP:0002904)2.48273419
54Metabolic acidosis (HP:0001942)2.47957623
55Proximal tubulopathy (HP:0000114)2.45112378
56Hypoalphalipoproteinemia (HP:0003233)2.44502267
57Gingival bleeding (HP:0000225)2.38757232
58Gout (HP:0001997)2.36187400
59Cardiovascular calcification (HP:0011915)2.34564935
60Abnormality of the vitamin B12 metabolism (HP:0004341)2.34194982
61Hepatocellular carcinoma (HP:0001402)2.32759891
62Hypophosphatemia (HP:0002148)2.32508128
63Poikilocytosis (HP:0004447)2.29963455
64Facial shape deformation (HP:0011334)2.29830908
65Potter facies (HP:0002009)2.29830908
66Hypophosphatemic rickets (HP:0004912)2.29682547
67Nephrolithiasis (HP:0000787)2.28421820
68Confusion (HP:0001289)2.27303178
69Mitral stenosis (HP:0001718)2.26831643
70Abnormality of serum amino acid levels (HP:0003112)2.26771758
71Abnormality of vitamin B metabolism (HP:0004340)2.21135337
72Irritability (HP:0000737)2.14524997
73Alkalosis (HP:0001948)2.14296607
74Ileus (HP:0002595)2.13077140
75Abnormality of methionine metabolism (HP:0010901)2.12441225
76Pigmentary retinal degeneration (HP:0001146)2.12335728
77Hyperuricemia (HP:0002149)2.11912671
78Increased purine levels (HP:0004368)2.11912671
79Abnormal enzyme/coenzyme activity (HP:0012379)2.11038371
80Megaloblastic anemia (HP:0001889)2.08435864
81Elevated alkaline phosphatase (HP:0003155)2.06252474
82Nausea (HP:0002018)2.05313475
83Abnormality of alkaline phosphatase activity (HP:0004379)2.04925031
84Purpura (HP:0000979)2.01109269
85Abdominal distention (HP:0003270)1.97732584
86Thrombophlebitis (HP:0004418)1.95686605
87Pancreatitis (HP:0001733)1.87882880
88Chronic diarrhea (HP:0002028)1.83962372
89Focal segmental glomerulosclerosis (HP:0000097)1.83224256
90Pulmonary embolism (HP:0002204)1.82388781
91Cerebral palsy (HP:0100021)1.82238247
92Ketosis (HP:0001946)1.82140795
93Skin nodule (HP:0200036)1.80217568
94Menorrhagia (HP:0000132)1.78964876
95Wide cranial sutures (HP:0010537)1.78452769
96Protuberant abdomen (HP:0001538)1.77482450
97Enlarged kidneys (HP:0000105)1.75151254
98Neonatal hypoglycemia (HP:0001998)1.72301259
99Myocardial infarction (HP:0001658)1.71798569
100Lethargy (HP:0001254)1.71670761

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.17692675
2ACVR1B5.79054891
3RIPK14.15496481
4FGFR43.56622595
5MST1R3.18939484
6PRKG22.39606929
7TYK22.27596374
8PRPF4B2.04148561
9MAP3K22.03726362
10EPHA21.91441353
11FGFR31.84034242
12EPHA31.73683589
13PIK3CG1.70328857
14PIK3CA1.62823138
15MAP3K31.60529597
16TRIB31.55329616
17PRKACG1.55256619
18MAPK111.51571286
19PRKAA21.42515682
20MAP3K101.37900087
21SIK11.37162653
22TESK21.37111579
23PDPK11.35357566
24EPHA41.32932354
25PTK61.29096587
26GRK61.28738654
27MAP3K11.26292020
28MAP3K121.19667363
29EPHB11.18750469
30ERBB21.18159566
31PDK21.17535526
32AKT31.16780071
33DYRK1B1.16064181
34MYLK1.06490246
35MET1.03951837
36TBK11.01445572
37NLK1.01400477
38PDK10.99497337
39MAP3K110.93840301
40KSR20.89510690
41PRKCZ0.84836331
42RET0.84444065
43MAP4K10.82231404
44JAK10.81898812
45ICK0.81355723
46IRAK30.81266687
47PINK10.80759417
48NEK90.79871277
49JAK20.77709562
50IGF1R0.77709552
51ABL20.75890163
52CSF1R0.75734480
53MAP2K40.75024564
54OXSR10.74269622
55MAP2K20.74210184
56CDK60.72434836
57STK390.67513536
58MATK0.64599208
59PRKCA0.63846128
60FER0.62025243
61IRAK10.56516910
62DDR20.55088351
63PRKACA0.51430870
64ZAP700.50655513
65BCKDK0.49950479
66MAP2K60.48953010
67SRC0.48729642
68PRKG10.48606629
69MAP3K50.48091834
70PRKAA10.46609155
71CDC42BPA0.46297805
72PIM10.45979656
73RIPK40.43389121
74PDGFRA0.43059524
75MAP3K60.41707605
76PKN20.41383627
77TAOK10.41320501
78TNIK0.39662117
79ADRBK20.38919220
80TAOK30.37636140
81FRK0.37464481
82PRKCB0.36778978
83YES10.34429059
84MAP3K140.32642908
85PRKCG0.31956827
86DAPK20.31557569
87FYN0.31416979
88LMTK20.30622231
89EEF2K0.30616837
90PRKCD0.30056543
91BMPR20.29770076
92SGK10.29392294
93SGK2230.29356295
94SGK4940.29356295
95IKBKE0.28742562
96MAPK70.28589383
97MAPK40.27956802
98SGK30.26597203
99GSK3A0.25267672
100MAPKAPK30.24595706

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.47322200
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.55144779
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.34512540
4Retinol metabolism_Homo sapiens_hsa008303.33983910
5Primary bile acid biosynthesis_Homo sapiens_hsa001203.22067779
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.94968491
7Complement and coagulation cascades_Homo sapiens_hsa046102.94777524
8Chemical carcinogenesis_Homo sapiens_hsa052042.93682172
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.88359358
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.86495911
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.79619368
12Drug metabolism - other enzymes_Homo sapiens_hsa009832.77347247
13Steroid hormone biosynthesis_Homo sapiens_hsa001402.58411052
14Arginine biosynthesis_Homo sapiens_hsa002202.48857079
15Fatty acid degradation_Homo sapiens_hsa000712.36499019
16Histidine metabolism_Homo sapiens_hsa003402.26633861
17Phenylalanine metabolism_Homo sapiens_hsa003602.19974486
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.09275670
19Starch and sucrose metabolism_Homo sapiens_hsa005002.09018794
20Fat digestion and absorption_Homo sapiens_hsa049752.08556990
21Linoleic acid metabolism_Homo sapiens_hsa005912.03658499
22Bile secretion_Homo sapiens_hsa049761.98179358
23Tryptophan metabolism_Homo sapiens_hsa003801.88767816
24Tyrosine metabolism_Homo sapiens_hsa003501.87849887
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.85614581
26Vitamin digestion and absorption_Homo sapiens_hsa049771.77562261
27Butanoate metabolism_Homo sapiens_hsa006501.76030308
28PPAR signaling pathway_Homo sapiens_hsa033201.70498963
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66230208
30Renin-angiotensin system_Homo sapiens_hsa046141.38233807
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25830870
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25051231
33Peroxisome_Homo sapiens_hsa041461.16013861
34Arginine and proline metabolism_Homo sapiens_hsa003301.15693778
35* Arachidonic acid metabolism_Homo sapiens_hsa005901.11557727
36Staphylococcus aureus infection_Homo sapiens_hsa051501.06176410
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.05430432
38beta-Alanine metabolism_Homo sapiens_hsa004101.03588697
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01472763
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98055561
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97240140
42Maturity onset diabetes of the young_Homo sapiens_hsa049500.95216861
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94961951
44Pyruvate metabolism_Homo sapiens_hsa006200.93445522
45Biosynthesis of amino acids_Homo sapiens_hsa012300.89095067
46Vitamin B6 metabolism_Homo sapiens_hsa007500.87523273
47Fatty acid metabolism_Homo sapiens_hsa012120.87387292
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84403126
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81852398
50Fructose and mannose metabolism_Homo sapiens_hsa000510.80661489
51Mineral absorption_Homo sapiens_hsa049780.79378204
52Carbon metabolism_Homo sapiens_hsa012000.77294051
53Propanoate metabolism_Homo sapiens_hsa006400.76193052
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75443763
55ABC transporters_Homo sapiens_hsa020100.75345748
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.74106344
57Galactose metabolism_Homo sapiens_hsa000520.70353590
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69727812
59Prion diseases_Homo sapiens_hsa050200.69218096
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68892128
61Glycerolipid metabolism_Homo sapiens_hsa005610.67433689
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67395437
63Sulfur metabolism_Homo sapiens_hsa009200.63672815
64Protein digestion and absorption_Homo sapiens_hsa049740.62063982
65* Metabolic pathways_Homo sapiens_hsa011000.38678812
66Pentose phosphate pathway_Homo sapiens_hsa000300.36508741
67Sulfur relay system_Homo sapiens_hsa041220.35407157
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33039612
69Insulin resistance_Homo sapiens_hsa049310.32295388
70Lysine degradation_Homo sapiens_hsa003100.27777279
71Glutathione metabolism_Homo sapiens_hsa004800.24206010
72Fatty acid biosynthesis_Homo sapiens_hsa000610.22821163
73Fatty acid elongation_Homo sapiens_hsa000620.21549032
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.21140600
75Glucagon signaling pathway_Homo sapiens_hsa049220.21073730
76Other glycan degradation_Homo sapiens_hsa005110.20361236
77Sphingolipid metabolism_Homo sapiens_hsa006000.18835893
78One carbon pool by folate_Homo sapiens_hsa006700.18789563
79Pertussis_Homo sapiens_hsa051330.18042196
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.12493742
81Folate biosynthesis_Homo sapiens_hsa007900.11272793
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11133863
83Ether lipid metabolism_Homo sapiens_hsa005650.07922573
84AMPK signaling pathway_Homo sapiens_hsa041520.04812271
85Serotonergic synapse_Homo sapiens_hsa047260.00326904
86Cocaine addiction_Homo sapiens_hsa05030-0.2165421
87Hepatitis C_Homo sapiens_hsa05160-0.1979108
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1939848
89Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1497162
90Pancreatic secretion_Homo sapiens_hsa04972-0.1395231
91Selenocompound metabolism_Homo sapiens_hsa00450-0.1341187
92Insulin signaling pathway_Homo sapiens_hsa04910-0.1338293
93Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1309886
94Amoebiasis_Homo sapiens_hsa05146-0.1040410
95African trypanosomiasis_Homo sapiens_hsa05143-0.0824665
96Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0823662
97Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0796138
98Steroid biosynthesis_Homo sapiens_hsa00100-0.0446107
99Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0344302
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0221241

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