CYP4A22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.75253524
2omega-hydroxylase P450 pathway (GO:0097267)9.57453274
3epoxygenase P450 pathway (GO:0019373)9.49992869
4drug catabolic process (GO:0042737)9.31688552
5glyoxylate metabolic process (GO:0046487)8.41530687
6complement activation, alternative pathway (GO:0006957)8.12376449
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)8.11462319
8L-phenylalanine catabolic process (GO:0006559)8.11462319
9regulation of fibrinolysis (GO:0051917)8.10658977
10negative regulation of fibrinolysis (GO:0051918)7.40768489
11regulation of protein activation cascade (GO:2000257)7.36335119
12L-phenylalanine metabolic process (GO:0006558)7.33460118
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.33460118
14ethanol oxidation (GO:0006069)7.18067734
15regulation of complement activation (GO:0030449)7.01199390
16protein carboxylation (GO:0018214)6.48109580
17peptidyl-glutamic acid carboxylation (GO:0017187)6.48109580
18urea metabolic process (GO:0019627)6.47588252
19drug metabolic process (GO:0017144)6.46950040
20fibrinolysis (GO:0042730)6.32387648
21negative regulation of sterol transport (GO:0032372)6.25640116
22negative regulation of cholesterol transport (GO:0032375)6.25640116
23aromatic amino acid family catabolic process (GO:0009074)6.24019214
24oxidative demethylation (GO:0070989)6.23860602
25serine family amino acid catabolic process (GO:0009071)6.12725664
26nitrogen cycle metabolic process (GO:0071941)5.86389808
27triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.86079720
28blood coagulation, intrinsic pathway (GO:0007597)5.85446758
29bile acid biosynthetic process (GO:0006699)5.83448114
30imidazole-containing compound metabolic process (GO:0052803)5.77926961
31ethanol metabolic process (GO:0006067)5.77751538
32regulation of triglyceride catabolic process (GO:0010896)5.61028495
33urea cycle (GO:0000050)5.59809848
34cellular glucuronidation (GO:0052695)5.53261793
35glucuronate metabolic process (GO:0019585)5.28671479
36uronic acid metabolic process (GO:0006063)5.28671479
37phenylpropanoid metabolic process (GO:0009698)5.27744809
38glycine metabolic process (GO:0006544)5.26541539
39regulation of plasminogen activation (GO:0010755)5.22699359
40bile acid metabolic process (GO:0008206)5.11443766
41S-adenosylmethionine metabolic process (GO:0046500)5.04487272
42protein activation cascade (GO:0072376)5.03445732
43tyrosine metabolic process (GO:0006570)4.98255952
44complement activation (GO:0006956)4.74799524
45complement activation, classical pathway (GO:0006958)4.70195765
46negative regulation of blood coagulation (GO:0030195)4.68275435
47negative regulation of hemostasis (GO:1900047)4.68275435
48phospholipid efflux (GO:0033700)4.62563549
49bile acid and bile salt transport (GO:0015721)4.62495102
50indole-containing compound catabolic process (GO:0042436)4.57403121
51indolalkylamine catabolic process (GO:0046218)4.57403121
52tryptophan catabolic process (GO:0006569)4.57403121
53acylglycerol homeostasis (GO:0055090)4.54204599
54triglyceride homeostasis (GO:0070328)4.54204599
55glutamate metabolic process (GO:0006536)4.46605678
56regulation of humoral immune response (GO:0002920)4.42654944
57opsonization (GO:0008228)4.41702954
58alkaloid metabolic process (GO:0009820)4.39656278
59positive regulation of triglyceride lipase activity (GO:0061365)4.36855398
60positive regulation of lipoprotein lipase activity (GO:0051006)4.36855398
61plasma lipoprotein particle remodeling (GO:0034369)4.35109838
62protein-lipid complex remodeling (GO:0034368)4.35109838
63macromolecular complex remodeling (GO:0034367)4.35109838
64cellular ketone body metabolic process (GO:0046950)4.31009935
65alpha-amino acid catabolic process (GO:1901606)4.29837510
66cholesterol efflux (GO:0033344)4.28527107
67amino-acid betaine metabolic process (GO:0006577)4.27883197
68serine family amino acid metabolic process (GO:0009069)4.25705159
69negative regulation of protein activation cascade (GO:2000258)4.24474596
70negative regulation of coagulation (GO:0050819)4.24074421
71aromatic amino acid family metabolic process (GO:0009072)4.17922502
72negative regulation of wound healing (GO:0061045)4.17522216
73high-density lipoprotein particle remodeling (GO:0034375)4.17246658
74killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.14842727
75disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.14842727
76acute-phase response (GO:0006953)4.12749843
77cytolysis (GO:0019835)4.06433207
78positive regulation of blood coagulation (GO:0030194)4.02807961
79positive regulation of hemostasis (GO:1900048)4.02807961
80arginine metabolic process (GO:0006525)4.00893500
81reverse cholesterol transport (GO:0043691)3.93659250
82tryptophan metabolic process (GO:0006568)3.89585079
83flavonoid metabolic process (GO:0009812)3.83071113
84ketone body metabolic process (GO:1902224)3.81786239
85negative regulation of lipase activity (GO:0060192)3.79442756
86intestinal cholesterol absorption (GO:0030299)3.73917334
87regulation of cholesterol esterification (GO:0010872)3.72066381
88positive regulation of coagulation (GO:0050820)3.69116886
89response to mercury ion (GO:0046689)3.67441065
90cellular amino acid catabolic process (GO:0009063)3.67410178
91serine family amino acid biosynthetic process (GO:0009070)3.62863611
92xenobiotic metabolic process (GO:0006805)3.60476407
93cysteine metabolic process (GO:0006534)3.59093198
94negative regulation of complement activation (GO:0045916)3.56819248
95sodium-independent organic anion transport (GO:0043252)3.54358621
96heme transport (GO:0015886)3.52233012
97hormone catabolic process (GO:0042447)3.42513331
98positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.42459925
99positive regulation of lipid catabolic process (GO:0050996)3.40842552
100fat-soluble vitamin biosynthetic process (GO:0042362)3.34131880

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse7.07117356
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.65655937
3LXR_22158963_ChIP-Seq_LIVER_Mouse5.57807096
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.48141421
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.12249859
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.42610059
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.21889806
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.75685649
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.50628127
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.15186788
11HTT_18923047_ChIP-ChIP_STHdh_Human2.14177004
12HNF4A_19822575_ChIP-Seq_HepG2_Human2.04284752
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.6015860
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.96409455
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.89981194
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.81451060
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68625638
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56665714
19BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.51556150
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.42685180
21BCAT_22108803_ChIP-Seq_LS180_Human1.40049679
22ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36120669
23IRF1_19129219_ChIP-ChIP_H3396_Human1.28657285
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23052795
25AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.22019603
26PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21280710
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.18626551
28AR_20517297_ChIP-Seq_VCAP_Human1.02558155
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.01793583
30ER_23166858_ChIP-Seq_MCF-7_Human1.01708940
31GBX2_23144817_ChIP-Seq_PC3_Human1.00592960
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97770478
33IRF8_22096565_ChIP-ChIP_GC-B_Human0.97132748
34* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95769841
35TP53_18474530_ChIP-ChIP_U2OS_Human0.94109077
36ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94028080
37* PHF8_20622853_ChIP-Seq_HELA_Human0.93943503
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92892357
39GATA1_22025678_ChIP-Seq_K562_Human0.92323822
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92290934
41* HNFA_21074721_ChIP-Seq_CACO-2_Human0.91999898
42CBP_21632823_ChIP-Seq_H3396_Human0.91558535
43CEBPB_22108803_ChIP-Seq_LS180_Human0.91212103
44IGF1R_20145208_ChIP-Seq_DFB_Human0.90120090
45EZH2_27294783_Chip-Seq_NPCs_Mouse0.89721095
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88668453
47CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85093570
48RXRA_24833708_ChIP-Seq_LIVER_Mouse0.84026145
49FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83696201
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83149956
51SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82402385
52CDX2_22108803_ChIP-Seq_LS180_Human0.82399610
53ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82222678
54GATA4_25053715_ChIP-Seq_YYC3_Human0.81819234
55FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.81617527
56* NFYA_21822215_ChIP-Seq_K562_Human0.81366749
57TAF15_26573619_Chip-Seq_HEK293_Human0.80442633
58* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.78012394
59* ETV1_20927104_ChIP-Seq_GIST48_Human0.77809585
60* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.77379296
61KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77359315
62KLF5_20875108_ChIP-Seq_MESCs_Mouse0.76547032
63CRX_20693478_ChIP-Seq_RETINA_Mouse0.76214221
64ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76077411
65FOXA1_25552417_ChIP-Seq_VCAP_Human0.75547350
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.75476886
67* GATA6_21074721_ChIP-Seq_CACO-2_Human0.74923244
68SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.73433282
69PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73251500
70* RAC3_21632823_ChIP-Seq_H3396_Human0.72114303
71SOX2_21211035_ChIP-Seq_LN229_Human0.71941514
72SOX2_19829295_ChIP-Seq_ESCs_Human0.71842990
73NANOG_19829295_ChIP-Seq_ESCs_Human0.71842990
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.71653180
75CBP_20019798_ChIP-Seq_JUKART_Human0.71653180
76STAT3_23295773_ChIP-Seq_U87_Human0.70113991
77CTBP1_25329375_ChIP-Seq_LNCAP_Human0.70101839
78TCF4_22108803_ChIP-Seq_LS180_Human0.69421579
79MYC_19829295_ChIP-Seq_ESCs_Human0.69278241
80* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.68950489
81P53_21459846_ChIP-Seq_SAOS-2_Human0.68863249
82FOXH1_21741376_ChIP-Seq_EPCs_Human0.68484934
83ERG_20517297_ChIP-Seq_VCAP_Human0.67978933
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.67772632
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.67519337
86TCF4_23295773_ChIP-Seq_U87_Human0.67450101
87TP53_16413492_ChIP-PET_HCT116_Human0.67423826
88AUTS2_25519132_ChIP-Seq_293T-REX_Human0.66996204
89* NFYB_21822215_ChIP-Seq_K562_Human0.66882314
90OCT4_21477851_ChIP-Seq_ESCs_Mouse0.66063187
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.65955687
92OCT4_18555785_Chip-Seq_ESCs_Mouse0.65264262
93TAF2_19829295_ChIP-Seq_ESCs_Human0.63495219
94NCOR_22424771_ChIP-Seq_293T_Human0.62755666
95PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.62313877
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.62143493
97TCF4_18268006_ChIP-ChIP_LS174T_Human0.61920995
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.60392511
99* RBPJ_21746931_ChIP-Seq_IB4_Human0.59902897
100CDX2_19796622_ChIP-Seq_MESCs_Mouse0.59789394

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.47347416
2MP0005360_urolithiasis6.55213220
3MP0005085_abnormal_gallbladder_physiolo6.37994334
4MP0003195_calcinosis5.98224143
5MP0008875_abnormal_xenobiotic_pharmacok5.88017972
6MP0005365_abnormal_bile_salt5.45637396
7MP0002138_abnormal_hepatobiliary_system4.19387903
8MP0003252_abnormal_bile_duct4.10750338
9MP0001666_abnormal_nutrient_absorption3.06203898
10MP0010329_abnormal_lipoprotein_level2.96346389
11MP0003868_abnormal_feces_composition2.84177516
12MP0009697_abnormal_copulation2.66399041
13MP0005332_abnormal_amino_acid2.54492846
14MP0003806_abnormal_nucleotide_metabolis2.36555337
15MP0003191_abnormal_cellular_cholesterol2.07480955
16MP0002876_abnormal_thyroid_physiology2.01544686
17MP0010368_abnormal_lymphatic_system1.83768753
18MP0000609_abnormal_liver_physiology1.79004227
19MP0009840_abnormal_foam_cell1.78502780
20MP0002118_abnormal_lipid_homeostasis1.70926359
21MP0001764_abnormal_homeostasis1.64090860
22MP0004019_abnormal_vitamin_homeostasis1.38902097
23MP0005670_abnormal_white_adipose1.35239842
24MP0009053_abnormal_anal_canal1.24310024
25MP0005408_hypopigmentation1.18047966
26MP0003656_abnormal_erythrocyte_physiolo1.16922157
27MP0001661_extended_life_span1.11896074
28MP0005319_abnormal_enzyme/_coenzyme1.10908996
29MP0002132_abnormal_respiratory_system1.08124172
30MP0008872_abnormal_physiological_respon1.07741299
31MP0009643_abnormal_urine_homeostasis1.07172897
32MP0000598_abnormal_liver_morphology1.03226131
33MP0009764_decreased_sensitivity_to0.99285242
34MP0005584_abnormal_enzyme/coenzyme_acti0.97172277
35MP0002971_abnormal_brown_adipose0.93966012
36MP0002282_abnormal_trachea_morphology0.89133173
37MP0002168_other_aberrant_phenotype0.86551104
38MP0003879_abnormal_hair_cell0.86338173
39MP0005376_homeostasis/metabolism_phenot0.85074407
40MP0005395_other_phenotype0.84314729
41MP0009642_abnormal_blood_homeostasis0.81220090
42MP0005636_abnormal_mineral_homeostasis0.76279332
43MP0009763_increased_sensitivity_to0.75881837
44MP0003186_abnormal_redox_activity0.74708071
45MP0005535_abnormal_body_temperature0.72765709
46MP0005266_abnormal_metabolism0.72240683
47MP0008469_abnormal_protein_level0.69730744
48MP0002249_abnormal_larynx_morphology0.67490108
49MP0005334_abnormal_fat_pad0.67051954
50MP0003690_abnormal_glial_cell0.66468947
51MP0005083_abnormal_biliary_tract0.64262106
52MP0002078_abnormal_glucose_homeostasis0.62779820
53MP0005187_abnormal_penis_morphology0.62080099
54MP0001915_intracranial_hemorrhage0.61615902
55MP0004043_abnormal_pH_regulation0.60308369
56MP0005451_abnormal_body_composition0.59215658
57MP0008874_decreased_physiological_sensi0.56250412
58MP0004130_abnormal_muscle_cell0.55312333
59MP0000604_amyloidosis0.55188871
60MP0003638_abnormal_response/metabolism_0.54749398
61MP0003011_delayed_dark_adaptation0.52795581
62MP0005464_abnormal_platelet_physiology0.45522800
63MP0005448_abnormal_energy_balance0.44956538
64MP0004782_abnormal_surfactant_physiolog0.44259116
65MP0000566_synostosis0.43571931
66MP0006036_abnormal_mitochondrial_physio0.43544275
67MP0001986_abnormal_taste_sensitivity0.40302554
68MP0005646_abnormal_pituitary_gland0.40209919
69MP0001756_abnormal_urination0.40196216
70MP0009785_altered_susceptibility_to0.40157268
71MP0009765_abnormal_xenobiotic_induced0.39066198
72MP0005220_abnormal_exocrine_pancreas0.38466136
73MP0002136_abnormal_kidney_physiology0.38120002
74MP0001545_abnormal_hematopoietic_system0.37003318
75MP0005397_hematopoietic_system_phenotyp0.37003318
76MP0002928_abnormal_bile_duct0.36376608
77MP0005166_decreased_susceptibility_to0.35486384
78MP0003718_maternal_effect0.35161863
79MP0002332_abnormal_exercise_endurance0.34465546
80MP0004883_abnormal_blood_vessel0.34129869
81MP0003953_abnormal_hormone_level0.34000603
82MP0000249_abnormal_blood_vessel0.33402608
83MP0003075_altered_response_to0.31788645
84MP0000639_abnormal_adrenal_gland0.31705327
85MP0005551_abnormal_eye_electrophysiolog0.31264747
86MP0005647_abnormal_sex_gland0.31066560
87MP0005164_abnormal_response_to0.29306641
88MP0005023_abnormal_wound_healing0.28904865
89MP0009115_abnormal_fat_cell0.25809931
90MP0000467_abnormal_esophagus_morphology0.25792920
91MP0002970_abnormal_white_adipose0.24104427
92MP0005084_abnormal_gallbladder_morpholo0.23486451
93MP0003633_abnormal_nervous_system0.22488676
94MP0001944_abnormal_pancreas_morphology0.21336154
95MP0003959_abnormal_lean_body0.21304878
96MP0008873_increased_physiological_sensi0.20153710
97MP0005377_hearing/vestibular/ear_phenot0.19847124
98MP0003878_abnormal_ear_physiology0.19847124
99MP0001851_eye_inflammation0.18040365
100MP0004142_abnormal_muscle_tone0.17495889

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)9.67336408
2Complement deficiency (HP:0004431)9.61055933
3Prolonged partial thromboplastin time (HP:0003645)9.31837283
4Abnormality of aromatic amino acid family metabolism (HP:0004338)8.52289211
5Abnormality of complement system (HP:0005339)7.65070012
6Hypobetalipoproteinemia (HP:0003563)7.22187613
7Joint hemorrhage (HP:0005261)6.51429684
8Conjugated hyperbilirubinemia (HP:0002908)6.37322359
9Systemic lupus erythematosus (HP:0002725)6.31739928
10Hyperlipoproteinemia (HP:0010980)5.88264432
11Xanthomatosis (HP:0000991)5.36926232
12Abnormality of pyrimidine metabolism (HP:0004353)5.22834276
13Glomerulonephritis (HP:0000099)4.97996260
14Intrahepatic cholestasis (HP:0001406)4.96420741
15Recurrent gram-negative bacterial infections (HP:0005420)4.54145432
16Abnormality of the intrinsic pathway (HP:0010989)4.26352908
17Hypolipoproteinemia (HP:0010981)4.21185152
18Abnormality of the common coagulation pathway (HP:0010990)4.06175193
19Spontaneous abortion (HP:0005268)3.95128546
20Nephritis (HP:0000123)3.78084339
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.75275959
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.71471100
23Abnormality of methionine metabolism (HP:0010901)3.66697042
24Hyperglycinemia (HP:0002154)3.49297861
25Delayed CNS myelination (HP:0002188)3.40796198
26Fair hair (HP:0002286)3.27459831
27Hypoalphalipoproteinemia (HP:0003233)3.24631539
28Abnormality of serine family amino acid metabolism (HP:0010894)3.18377884
29Abnormality of glycine metabolism (HP:0010895)3.18377884
30Hyperammonemia (HP:0001987)3.15293658
31Generalized aminoaciduria (HP:0002909)3.10594412
32Neonatal hypoglycemia (HP:0001998)3.08333797
33Hypercholesterolemia (HP:0003124)3.02977077
34Mitral stenosis (HP:0001718)3.01829218
35Fat malabsorption (HP:0002630)3.00968964
36Abnormality of nucleobase metabolism (HP:0010932)2.91339939
37Abnormality of aspartate family amino acid metabolism (HP:0010899)2.90289549
38Vascular calcification (HP:0004934)2.86053444
39Epidermoid cyst (HP:0200040)2.82457842
40Hyperglycinuria (HP:0003108)2.72697582
41Rickets (HP:0002748)2.70560206
42Abnormality of serum amino acid levels (HP:0003112)2.67583913
43Osteomalacia (HP:0002749)2.66994672
44Hemorrhage of the eye (HP:0011885)2.64857842
45Abnormality of sulfur amino acid metabolism (HP:0004339)2.58798606
46Gingival bleeding (HP:0000225)2.58609392
47Cardiovascular calcification (HP:0011915)2.51155730
48Thrombophlebitis (HP:0004418)2.50833523
49Hyperbilirubinemia (HP:0002904)2.49731064
50Steatorrhea (HP:0002570)2.46434941
51Menorrhagia (HP:0000132)2.36706637
52Purpura (HP:0000979)2.35916042
53Pulmonary embolism (HP:0002204)2.31800028
54Generalized hypopigmentation of hair (HP:0011358)2.30903872
55Hepatocellular carcinoma (HP:0001402)2.29537982
56Ketosis (HP:0001946)2.29401772
57Arthropathy (HP:0003040)2.27906489
58Metabolic acidosis (HP:0001942)2.23545972
59Hyperphosphaturia (HP:0003109)2.11688145
60Blue irides (HP:0000635)2.08146270
61Alkalosis (HP:0001948)2.04945454
62Abnormality of vitamin metabolism (HP:0100508)2.03456646
63Cholelithiasis (HP:0001081)2.01712277
64Glycosuria (HP:0003076)2.00798550
65Abnormality of urine glucose concentration (HP:0011016)2.00798550
66Abnormality of monocarboxylic acid metabolism (HP:0010996)10.4933058
67Abnormal gallbladder physiology (HP:0012438)1.94542142
68Cholecystitis (HP:0001082)1.94542142
69Hypophosphatemic rickets (HP:0004912)1.93423494
70Reduced antithrombin III activity (HP:0001976)1.92107248
71Abnormal gallbladder morphology (HP:0012437)1.90948108
72Cerebral palsy (HP:0100021)1.88762504
73Increased mean platelet volume (HP:0011877)1.86728645
74Abnormality of purine metabolism (HP:0004352)1.85238369
75Irritability (HP:0000737)1.85162089
76Gangrene (HP:0100758)1.82803362
77Poikilocytosis (HP:0004447)1.80235933
78Myocardial infarction (HP:0001658)1.79700318
79Gout (HP:0001997)1.74827956
80Elevated alkaline phosphatase (HP:0003155)1.72839906
81Enlarged kidneys (HP:0000105)1.72707966
82Bifid scrotum (HP:0000048)1.72528820
83Abnormality of proline metabolism (HP:0010907)1.69213115
84Hydroxyprolinuria (HP:0003080)1.69213115
85Abnormality of iron homeostasis (HP:0011031)1.67700654
86Abnormal urine phosphate concentration (HP:0012599)1.67601919
87Impaired platelet aggregation (HP:0003540)1.67109578
88Abnormal platelet function (HP:0011869)1.67109578
89Abnormal platelet volume (HP:0011876)1.66957987
90Abnormal biliary tract physiology (HP:0012439)1.66351809
91Bile duct proliferation (HP:0001408)1.66351809
92Hypochromic microcytic anemia (HP:0004840)1.66186513
93Lethargy (HP:0001254)1.66040708
94Joint swelling (HP:0001386)1.65257102
95Atrioventricular block (HP:0001678)1.65058118
96Pancreatitis (HP:0001733)1.62165292
97Increased serum ferritin (HP:0003281)1.62043425
98Abnormal enzyme/coenzyme activity (HP:0012379)1.62042762
99Abnormality of the Achilles tendon (HP:0005109)1.60859965
100Epistaxis (HP:0000421)1.57922858

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.41654493
2FRK4.97655424
3WNK33.71778627
4PIK3CG3.07282845
5BCKDK2.63993038
6FGFR42.34232375
7PIK3CA2.31822697
8CAMKK22.07717957
9PRKACG2.04132153
10PRKCG1.93088377
11INSRR1.89528887
12MAPK111.87783748
13TYK21.86891664
14ADRBK21.85559830
15TNK21.82281841
16PRKAA21.81074195
17LATS11.77569816
18SIK11.77025387
19NTRK31.73789677
20WNK41.72599513
21TAOK31.57464448
22MAP2K41.54890774
23OXSR11.53479019
24PDK21.41670570
25TRIB31.37915836
26NEK91.32460377
27GRK11.31204143
28PKN21.25093193
29IGF1R1.22223588
30PINK11.20695114
31ERBB21.19354253
32SGK21.17183722
33ACVR1B1.16424049
34NUAK11.12640853
35FGFR21.12494650
36CCNB11.05924712
37FER1.02673353
38TIE11.02444956
39BMPR1B0.99189910
40PRKG10.97907025
41RIPK10.95363971
42PRKACA0.94138999
43PRKAA10.92732770
44AKT30.92677453
45NLK0.88508833
46STK390.87522821
47CASK0.86966344
48SGK2230.86913319
49SGK4940.86913319
50JAK10.86638808
51MAP4K20.86121993
52PRKCZ0.80922611
53DAPK20.80635179
54SGK30.78885051
55CAMK1D0.78047528
56PDPK10.75735607
57CSNK1D0.74561038
58EPHA40.71760229
59FGFR30.70940173
60BRSK20.69853289
61PDK10.69488301
62ABL20.65786338
63MAP3K30.61972617
64CSF1R0.61000801
65PRKCA0.60627701
66PRKCB0.60409271
67SGK10.60053604
68MAPK40.59114245
69TNIK0.58758278
70EPHA30.58240664
71RPS6KA30.57614682
72MAPK70.57489822
73KDR0.56687877
74JAK20.55917325
75CAMK1G0.55475953
76PRKCE0.55223888
77PRKACB0.55047307
78MUSK0.54121441
79MAPK120.52774657
80PLK40.52398405
81CAMKK10.52147917
82CSNK1A10.49758764
83MAPKAPK30.49452465
84TGFBR20.48050228
85CSNK1E0.46190949
86MELK0.45855824
87PAK30.45725875
88MAPKAPK50.45472470
89ADRBK10.45115037
90BLK0.44054632
91CAMK40.43841217
92BCR0.42217964
93CSNK1G10.38655365
94NEK20.37727497
95CDK60.36799760
96CSNK2A10.36032757
97MST1R0.34604797
98GSK3A0.34385266
99MAP3K20.34317178
100CHUK0.34233941

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.46613392
2Caffeine metabolism_Homo sapiens_hsa002324.43881837
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.91489759
4Complement and coagulation cascades_Homo sapiens_hsa046103.78150892
5Retinol metabolism_Homo sapiens_hsa008303.46169720
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.43133763
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.18692030
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.88379883
9Chemical carcinogenesis_Homo sapiens_hsa052042.85839029
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.83988648
11Arginine biosynthesis_Homo sapiens_hsa002202.57733251
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.51418205
13Phenylalanine metabolism_Homo sapiens_hsa003602.49739047
14* Fatty acid degradation_Homo sapiens_hsa000712.47310234
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.46667837
16Tyrosine metabolism_Homo sapiens_hsa003502.40564349
17Drug metabolism - other enzymes_Homo sapiens_hsa009832.35537227
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.22703874
19Histidine metabolism_Homo sapiens_hsa003402.11367866
20Butanoate metabolism_Homo sapiens_hsa006502.09090259
21Tryptophan metabolism_Homo sapiens_hsa003801.93501960
22Linoleic acid metabolism_Homo sapiens_hsa005911.79420668
23Bile secretion_Homo sapiens_hsa049761.67840041
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.63096043
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59868860
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57414054
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.53819984
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.51146585
29Starch and sucrose metabolism_Homo sapiens_hsa005001.44249377
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.40587441
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34080249
32beta-Alanine metabolism_Homo sapiens_hsa004101.33751072
33PPAR signaling pathway_Homo sapiens_hsa033201.32855822
34Peroxisome_Homo sapiens_hsa041461.27477564
35Staphylococcus aureus infection_Homo sapiens_hsa051501.24588660
36Arachidonic acid metabolism_Homo sapiens_hsa005901.20379144
37Biosynthesis of amino acids_Homo sapiens_hsa012301.12567322
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12323145
39Prion diseases_Homo sapiens_hsa050201.09835888
40Pyruvate metabolism_Homo sapiens_hsa006201.03407006
41Propanoate metabolism_Homo sapiens_hsa006400.97340496
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97027679
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96380516
44Vitamin B6 metabolism_Homo sapiens_hsa007500.93319485
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91837009
46Arginine and proline metabolism_Homo sapiens_hsa003300.91607960
47ABC transporters_Homo sapiens_hsa020100.87372316
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86491124
49One carbon pool by folate_Homo sapiens_hsa006700.86077280
50Carbon metabolism_Homo sapiens_hsa012000.82159441
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78958925
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69252579
53Fat digestion and absorption_Homo sapiens_hsa049750.68805604
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.66821901
55Fatty acid metabolism_Homo sapiens_hsa012120.64600163
56Lysine degradation_Homo sapiens_hsa003100.53023410
57Metabolic pathways_Homo sapiens_hsa011000.45533173
58Sulfur relay system_Homo sapiens_hsa041220.39910120
59Glycerolipid metabolism_Homo sapiens_hsa005610.34826046
60Sulfur metabolism_Homo sapiens_hsa009200.30281896
61Pertussis_Homo sapiens_hsa051330.25714147
62Insulin resistance_Homo sapiens_hsa049310.24797261
63Glucagon signaling pathway_Homo sapiens_hsa049220.22378131
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18820691
65Fatty acid elongation_Homo sapiens_hsa000620.16543183
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14990323
67Pentose phosphate pathway_Homo sapiens_hsa000300.14266566
68Fructose and mannose metabolism_Homo sapiens_hsa000510.14078359
69Systemic lupus erythematosus_Homo sapiens_hsa053220.13253210
70Glutathione metabolism_Homo sapiens_hsa004800.05072788
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.04216062
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.03891116
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.03815178
74Selenocompound metabolism_Homo sapiens_hsa004500.03809683
75Serotonergic synapse_Homo sapiens_hsa047260.03343804
76Vitamin digestion and absorption_Homo sapiens_hsa049770.01278163
77AMPK signaling pathway_Homo sapiens_hsa041520.01050407
78* Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2639908
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.2579837
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.2426675
81Ether lipid metabolism_Homo sapiens_hsa00565-0.2404563
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.2297654
83Other glycan degradation_Homo sapiens_hsa00511-0.2206445
84GABAergic synapse_Homo sapiens_hsa04727-0.2147760
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1991934
86Insulin signaling pathway_Homo sapiens_hsa04910-0.1801078
87Sphingolipid metabolism_Homo sapiens_hsa00600-0.1762920
88Circadian rhythm_Homo sapiens_hsa04710-0.1549890
89African trypanosomiasis_Homo sapiens_hsa05143-0.1442340
90Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1175791
91Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.1148022
92Galactose metabolism_Homo sapiens_hsa00052-0.1067557
93Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0913996
94Renin-angiotensin system_Homo sapiens_hsa04614-0.0815262
95Amoebiasis_Homo sapiens_hsa05146-0.0796109
96Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0718630
97Steroid biosynthesis_Homo sapiens_hsa00100-0.0711693
98Nitrogen metabolism_Homo sapiens_hsa00910-0.0554942
99Folate biosynthesis_Homo sapiens_hsa00790-0.0503917
100Mineral absorption_Homo sapiens_hsa04978-0.0488932

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