CYP3A43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein has a low level of testosterone hydroxylase activity, and may play a role in aging mechanisms and cancer progression. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.19194602
2indole-containing compound catabolic process (GO:0042436)4.68428101
3indolalkylamine catabolic process (GO:0046218)4.68428101
4tryptophan catabolic process (GO:0006569)4.68428101
5L-fucose catabolic process (GO:0042355)4.53838669
6fucose catabolic process (GO:0019317)4.53838669
7L-fucose metabolic process (GO:0042354)4.53838669
8cellular ketone body metabolic process (GO:0046950)4.52585532
9exogenous drug catabolic process (GO:0042738)4.39043952
10kynurenine metabolic process (GO:0070189)4.36906895
11indolalkylamine metabolic process (GO:0006586)4.13512704
12tryptophan metabolic process (GO:0006568)4.06142128
13ketone body metabolic process (GO:1902224)4.02963135
14drug catabolic process (GO:0042737)3.97917585
15DNA deamination (GO:0045006)3.78593396
16negative regulation of telomere maintenance (GO:0032205)3.68970352
17S-adenosylmethionine metabolic process (GO:0046500)3.66143334
18aromatic amino acid family catabolic process (GO:0009074)3.65717176
19detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.41397854
20water-soluble vitamin biosynthetic process (GO:0042364)3.39134170
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.26267571
22cellular biogenic amine catabolic process (GO:0042402)3.21591029
23amine catabolic process (GO:0009310)3.21591029
24piRNA metabolic process (GO:0034587)3.21127764
25indole-containing compound metabolic process (GO:0042430)3.17927413
26response to pheromone (GO:0019236)3.16132600
27preassembly of GPI anchor in ER membrane (GO:0016254)3.15413934
28protein-cofactor linkage (GO:0018065)3.14366966
29detection of light stimulus involved in sensory perception (GO:0050962)3.13053614
30detection of light stimulus involved in visual perception (GO:0050908)3.13053614
31phosphatidylinositol acyl-chain remodeling (GO:0036149)3.12508940
32gamma-aminobutyric acid transport (GO:0015812)3.09123561
33L-methionine biosynthetic process (GO:0071265)3.04800004
34amino acid salvage (GO:0043102)3.04800004
35L-methionine salvage (GO:0071267)3.04800004
36positive regulation of oligodendrocyte differentiation (GO:0048714)3.02083164
37axoneme assembly (GO:0035082)3.01582540
38protein polyglutamylation (GO:0018095)3.01506053
39mannosylation (GO:0097502)2.93002131
40platelet dense granule organization (GO:0060155)2.92680852
41oxidative demethylation (GO:0070989)2.91005408
42epithelial cilium movement (GO:0003351)2.88387899
43phosphatidylserine acyl-chain remodeling (GO:0036150)2.87316737
44cellular response to ATP (GO:0071318)2.86678993
45protein complex biogenesis (GO:0070271)2.84620157
46rRNA catabolic process (GO:0016075)2.82079828
47positive regulation of fatty acid transport (GO:2000193)2.79908215
48dopamine transport (GO:0015872)2.78741015
49sulfation (GO:0051923)2.78089469
50regulation of hexokinase activity (GO:1903299)2.76522163
51regulation of glucokinase activity (GO:0033131)2.76522163
52aromatic amino acid family metabolic process (GO:0009072)2.76503777
53respiratory chain complex IV assembly (GO:0008535)2.76375714
54neuronal action potential (GO:0019228)2.75219949
55benzene-containing compound metabolic process (GO:0042537)2.74082799
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.71300308
57mitochondrial respiratory chain complex I assembly (GO:0032981)2.71300308
58NADH dehydrogenase complex assembly (GO:0010257)2.71300308
59glyoxylate metabolic process (GO:0046487)2.70770179
60negative regulation of mast cell activation (GO:0033004)2.70474977
61neural tube formation (GO:0001841)2.69918756
62photoreceptor cell maintenance (GO:0045494)2.69111192
63regulation of cilium movement (GO:0003352)2.69041625
64proline transport (GO:0015824)2.68135916
65kidney morphogenesis (GO:0060993)2.64578843
66pyrimidine nucleobase catabolic process (GO:0006208)2.63199209
67negative regulation of synaptic transmission, GABAergic (GO:0032229)2.62158638
68arginine metabolic process (GO:0006525)2.61830774
69L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.61529956
70mitochondrial respiratory chain complex assembly (GO:0033108)2.60092286
71primary amino compound metabolic process (GO:1901160)2.60090367
72reflex (GO:0060004)2.59963804
73phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.59325627
74regulation of nuclear cell cycle DNA replication (GO:0033262)2.58348127
75cilium morphogenesis (GO:0060271)2.56601097
76synaptic transmission, cholinergic (GO:0007271)2.56347463
77DNA methylation involved in gamete generation (GO:0043046)2.56001647
78glycerophospholipid catabolic process (GO:0046475)2.54856882
79reciprocal meiotic recombination (GO:0007131)2.52781177
80reciprocal DNA recombination (GO:0035825)2.52781177
81ubiquinone biosynthetic process (GO:0006744)2.52575518
82multicellular organism reproduction (GO:0032504)2.52016664
83fucosylation (GO:0036065)2.50983205
84retinal cone cell development (GO:0046549)2.50824783
85regulation of action potential (GO:0098900)2.50733866
86nonmotile primary cilium assembly (GO:0035058)2.50522709
87RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.50353704
88L-phenylalanine catabolic process (GO:0006559)2.50167386
89erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.50167386
90alanine transport (GO:0032328)2.50087858
91omega-hydroxylase P450 pathway (GO:0097267)2.49503007
92auditory receptor cell stereocilium organization (GO:0060088)2.49419064
93epoxygenase P450 pathway (GO:0019373)2.47122114
94nucleobase catabolic process (GO:0046113)2.46350913
95cytochrome complex assembly (GO:0017004)2.46281585
96protein K11-linked deubiquitination (GO:0035871)2.45009385
97methionine biosynthetic process (GO:0009086)2.44404947
98behavioral response to ethanol (GO:0048149)2.44093459
99somite development (GO:0061053)2.43666997
100basic amino acid transport (GO:0015802)2.43631386

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.12744547
2VDR_22108803_ChIP-Seq_LS180_Human3.47489961
3GBX2_23144817_ChIP-Seq_PC3_Human2.96653569
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.64306099
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47842253
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.46177762
7IGF1R_20145208_ChIP-Seq_DFB_Human2.43410200
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.39135505
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38714260
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32754100
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14175566
12TAF15_26573619_Chip-Seq_HEK293_Human2.11176943
13EZH2_22144423_ChIP-Seq_EOC_Human2.01115249
14CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98858464
15FUS_26573619_Chip-Seq_HEK293_Human1.97838450
16CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97189522
17PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94416817
18EWS_26573619_Chip-Seq_HEK293_Human1.93671337
19P300_19829295_ChIP-Seq_ESCs_Human1.89597413
20IRF1_19129219_ChIP-ChIP_H3396_Human1.77847916
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74599210
22ER_23166858_ChIP-Seq_MCF-7_Human1.72531875
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.71264532
24* TP53_22573176_ChIP-Seq_HFKS_Human1.65871230
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65789575
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.64345042
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.60426874
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59614833
29BCAT_22108803_ChIP-Seq_LS180_Human1.58673506
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.58596272
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54387814
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50246921
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50045272
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47802031
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47119528
36CBP_20019798_ChIP-Seq_JUKART_Human1.47119528
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.46610930
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.46523569
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.46523569
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.44563198
41MYC_18940864_ChIP-ChIP_HL60_Human1.42977831
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42091394
43SOX2_19829295_ChIP-Seq_ESCs_Human1.40618640
44NANOG_19829295_ChIP-Seq_ESCs_Human1.40618640
45STAT3_23295773_ChIP-Seq_U87_Human1.37072151
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36479220
47AR_20517297_ChIP-Seq_VCAP_Human1.36463044
48* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35843404
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.35814492
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34856911
51AR_25329375_ChIP-Seq_VCAP_Human1.33093259
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31787929
53* TCF4_22108803_ChIP-Seq_LS180_Human1.31207557
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.30934629
55ETV2_25802403_ChIP-Seq_MESCs_Mouse1.30902583
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.30730575
57TCF4_23295773_ChIP-Seq_U87_Human1.30272349
58* GATA3_21878914_ChIP-Seq_MCF-7_Human1.29741196
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29612060
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28588814
61SMAD4_21799915_ChIP-Seq_A2780_Human1.28304640
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27633400
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26270803
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24707477
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24079335
66FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22598799
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21284142
68NCOR_22424771_ChIP-Seq_293T_Human1.21259552
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21200964
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.18799595
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18225348
72* HOXB7_26014856_ChIP-Seq_BT474_Human1.17768297
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16732680
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16482111
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16482111
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16468012
77REST_21632747_ChIP-Seq_MESCs_Mouse1.16295627
78SMAD4_21741376_ChIP-Seq_EPCs_Human1.15047456
79RUNX2_22187159_ChIP-Seq_PCA_Human1.11392713
80VDR_23849224_ChIP-Seq_CD4+_Human1.10537853
81MYC_19829295_ChIP-Seq_ESCs_Human1.09954114
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.07334326
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.06940638
84AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06541488
85* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06480632
86IRF8_22096565_ChIP-ChIP_GC-B_Human1.05620361
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.05554679
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05113572
89ELK1_19687146_ChIP-ChIP_HELA_Human1.04822944
90* CDX2_22108803_ChIP-Seq_LS180_Human1.04286785
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03451320
92RNF2_27304074_Chip-Seq_NSC_Mouse1.01777470
93FOXH1_21741376_ChIP-Seq_EPCs_Human1.00551739
94P53_22387025_ChIP-Seq_ESCs_Mouse1.00269345
95ERA_21632823_ChIP-Seq_H3396_Human1.00090467
96PRDM14_20953172_ChIP-Seq_ESCs_Human0.99677006
97AR_21572438_ChIP-Seq_LNCaP_Human0.99602199
98NANOG_18555785_Chip-Seq_ESCs_Mouse0.99412228
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99119742
100NANOG_20526341_ChIP-Seq_ESCs_Human0.98781223

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.97537630
2MP0008875_abnormal_xenobiotic_pharmacok3.31858284
3MP0008877_abnormal_DNA_methylation2.83563674
4MP0002102_abnormal_ear_morphology2.82297852
5MP0002837_dystrophic_cardiac_calcinosis2.59610107
6MP0005551_abnormal_eye_electrophysiolog2.43643338
7MP0005085_abnormal_gallbladder_physiolo2.15473464
8MP0002876_abnormal_thyroid_physiology2.11420247
9MP0006072_abnormal_retinal_apoptosis2.09292089
10MP0003787_abnormal_imprinting2.05646926
11MP0001968_abnormal_touch/_nociception2.01371294
12MP0008872_abnormal_physiological_respon1.97841456
13MP0002638_abnormal_pupillary_reflex1.94892044
14MP0004885_abnormal_endolymph1.91491398
15MP0001986_abnormal_taste_sensitivity1.91258479
16MP0002138_abnormal_hepatobiliary_system1.90235301
17MP0003646_muscle_fatigue1.88886162
18MP0003011_delayed_dark_adaptation1.86212503
19MP0005360_urolithiasis1.83605817
20MP0004142_abnormal_muscle_tone1.81887858
21MP0005365_abnormal_bile_salt1.80152646
22MP0001984_abnormal_olfaction1.78080089
23MP0005253_abnormal_eye_physiology1.76789331
24MP0005646_abnormal_pituitary_gland1.73616250
25MP0009745_abnormal_behavioral_response1.69525324
26MP0003252_abnormal_bile_duct1.68555311
27MP0000372_irregular_coat_pigmentation1.65228738
28MP0001501_abnormal_sleep_pattern1.63770566
29MP0006292_abnormal_olfactory_placode1.62772995
30MP0002163_abnormal_gland_morphology1.61013891
31MP0003880_abnormal_central_pattern1.60644310
32MP0005084_abnormal_gallbladder_morpholo1.57990263
33MP0005645_abnormal_hypothalamus_physiol1.55991432
34MP0002736_abnormal_nociception_after1.55912680
35MP0004147_increased_porphyrin_level1.51470038
36MP0005379_endocrine/exocrine_gland_phen1.51305870
37MP0009046_muscle_twitch1.43105290
38MP0002272_abnormal_nervous_system1.42652514
39MP0004043_abnormal_pH_regulation1.42546401
40MP0002653_abnormal_ependyma_morphology1.40440536
41MP0000427_abnormal_hair_cycle1.37463793
42MP0006276_abnormal_autonomic_nervous1.36354198
43MP0004133_heterotaxia1.35170312
44MP0005332_abnormal_amino_acid1.33101609
45MP0001485_abnormal_pinna_reflex1.28903845
46MP0002139_abnormal_hepatobiliary_system1.26921957
47MP0002938_white_spotting1.25132028
48MP0000569_abnormal_digit_pigmentation1.24475698
49MP0001486_abnormal_startle_reflex1.23404001
50MP0010329_abnormal_lipoprotein_level1.21986786
51MP0001764_abnormal_homeostasis1.21237250
52MP0004742_abnormal_vestibular_system1.20263522
53MP0003136_yellow_coat_color1.18734591
54MP0005389_reproductive_system_phenotype1.14984318
55MP0002572_abnormal_emotion/affect_behav1.14942772
56MP0003122_maternal_imprinting1.13355664
57MP0000631_abnormal_neuroendocrine_gland1.12469821
58MP0002234_abnormal_pharynx_morphology1.12423238
59MP0004145_abnormal_muscle_electrophysio1.10720707
60MP0002557_abnormal_social/conspecific_i1.05957975
61MP0001905_abnormal_dopamine_level1.05261682
62MP0002733_abnormal_thermal_nociception1.04472510
63MP0002928_abnormal_bile_duct1.03523915
64MP0002064_seizures0.99966719
65MP0002160_abnormal_reproductive_system0.99855939
66MP0001919_abnormal_reproductive_system0.98779666
67MP0008775_abnormal_heart_ventricle0.96721293
68MP0001970_abnormal_pain_threshold0.96232584
69MP0005167_abnormal_blood-brain_barrier0.96030353
70MP0005671_abnormal_response_to0.95806914
71MP0005386_behavior/neurological_phenoty0.94498357
72MP0004924_abnormal_behavior0.94498357
73MP0005195_abnormal_posterior_eye0.94219824
74MP0005075_abnormal_melanosome_morpholog0.94183109
75MP0001502_abnormal_circadian_rhythm0.92527511
76MP0009764_decreased_sensitivity_to0.92464198
77MP0005410_abnormal_fertilization0.91072089
78MP0004215_abnormal_myocardial_fiber0.89061076
79MP0010386_abnormal_urinary_bladder0.88530110
80MP0000383_abnormal_hair_follicle0.88409350
81MP0001529_abnormal_vocalization0.87745457
82MP0002693_abnormal_pancreas_physiology0.86678676
83MP0000230_abnormal_systemic_arterial0.84395747
84MP0002909_abnormal_adrenal_gland0.84008838
85MP0003121_genomic_imprinting0.81168817
86MP0002735_abnormal_chemical_nociception0.80725218
87MP0002063_abnormal_learning/memory/cond0.80622832
88MP0003718_maternal_effect0.80502704
89MP0003635_abnormal_synaptic_transmissio0.79820923
90MP0002751_abnormal_autonomic_nervous0.78203215
91MP0002277_abnormal_respiratory_mucosa0.77895587
92MP0002067_abnormal_sensory_capabilities0.77678921
93MP0002229_neurodegeneration0.76649115
94MP0000026_abnormal_inner_ear0.74782149
95MP0005377_hearing/vestibular/ear_phenot0.73704037
96MP0003878_abnormal_ear_physiology0.73704037
97MP0003806_abnormal_nucleotide_metabolis0.72021099
98MP0002752_abnormal_somatic_nervous0.71275602
99MP0001944_abnormal_pancreas_morphology0.70725614
100MP0006036_abnormal_mitochondrial_physio0.70657042

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.34081865
2Abnormality of midbrain morphology (HP:0002418)4.02021365
3Molar tooth sign on MRI (HP:0002419)4.02021365
4Pancreatic fibrosis (HP:0100732)3.96506244
5Congenital stationary night blindness (HP:0007642)3.85487251
6True hermaphroditism (HP:0010459)3.73892273
7Type II lissencephaly (HP:0007260)3.68536465
8Abnormality of the renal cortex (HP:0011035)3.62799677
9Nephronophthisis (HP:0000090)3.43793001
10Abnormality of the renal medulla (HP:0100957)3.08798812
11Medial flaring of the eyebrow (HP:0010747)2.98354168
12Chronic hepatic failure (HP:0100626)2.92082909
13Bile duct proliferation (HP:0001408)2.89195637
14Abnormal biliary tract physiology (HP:0012439)2.89195637
15Renal cortical cysts (HP:0000803)2.87097863
16Abolished electroretinogram (ERG) (HP:0000550)2.82470623
17Attenuation of retinal blood vessels (HP:0007843)2.82252157
18Abnormal drinking behavior (HP:0030082)2.75045753
19Polydipsia (HP:0001959)2.75045753
20Tubular atrophy (HP:0000092)2.71433341
21Cystic liver disease (HP:0006706)2.59861390
22Hyperventilation (HP:0002883)2.58376509
23Inability to walk (HP:0002540)2.55065409
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54334488
25Abnormality of alanine metabolism (HP:0010916)2.54334488
26Hyperalaninemia (HP:0003348)2.54334488
27Pendular nystagmus (HP:0012043)2.52505211
28Abnormal rod and cone electroretinograms (HP:0008323)2.45950673
29Stomach cancer (HP:0012126)2.41687985
30Progressive inability to walk (HP:0002505)2.38244016
31Increased corneal curvature (HP:0100692)2.35872404
32Keratoconus (HP:0000563)2.35872404
33Lissencephaly (HP:0001339)2.34611400
34Cerebellar dysplasia (HP:0007033)2.28803988
35Polyuria (HP:0000103)2.28437704
36Retinal dysplasia (HP:0007973)2.27473617
37Acute necrotizing encephalopathy (HP:0006965)2.27324020
38Decreased central vision (HP:0007663)2.25648157
393-Methylglutaconic aciduria (HP:0003535)2.24109184
40Large for gestational age (HP:0001520)2.22268612
41Ketosis (HP:0001946)2.21199633
42Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20033825
43Decreased circulating renin level (HP:0003351)2.18416265
44Stomatitis (HP:0010280)2.18118606
45Gait imbalance (HP:0002141)2.17727167
46Hyperglycinuria (HP:0003108)2.17284746
47Sclerocornea (HP:0000647)2.16025807
48Hypothermia (HP:0002045)2.15137517
49Congenital primary aphakia (HP:0007707)2.15137322
50Mitochondrial inheritance (HP:0001427)2.14877722
51Acute encephalopathy (HP:0006846)2.14829760
52Congenital hepatic fibrosis (HP:0002612)2.11654862
53Gaze-evoked nystagmus (HP:0000640)2.10543115
54Progressive macrocephaly (HP:0004481)2.08352968
55Increased CSF lactate (HP:0002490)2.07520845
56Nephrogenic diabetes insipidus (HP:0009806)2.07054104
57Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06909409
58Concave nail (HP:0001598)2.06429210
59Ketoacidosis (HP:0001993)2.02923737
60Hyperglycinemia (HP:0002154)2.02224019
61Optic disc pallor (HP:0000543)2.01544024
62Methylmalonic acidemia (HP:0002912)1.99881717
63Aplasia/Hypoplasia of the tongue (HP:0010295)1.98179330
64Abnormality of serine family amino acid metabolism (HP:0010894)1.96812390
65Abnormality of glycine metabolism (HP:0010895)1.96812390
66Aplasia/Hypoplasia of the tibia (HP:0005772)1.96691141
67Severe muscular hypotonia (HP:0006829)1.94470327
68Male pseudohermaphroditism (HP:0000037)1.94021726
69Abnormality of the labia minora (HP:0012880)1.93469517
70Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92988267
71Pachygyria (HP:0001302)1.92674139
72Abnormal mitochondria in muscle tissue (HP:0008316)1.92036172
73Furrowed tongue (HP:0000221)1.91920123
74Hypomagnesemia (HP:0002917)1.91912253
75Optic nerve hypoplasia (HP:0000609)1.91747683
76Abnormal urine output (HP:0012590)1.91515353
77Intestinal atresia (HP:0011100)1.91497404
78Tachypnea (HP:0002789)1.91216227
79Congenital, generalized hypertrichosis (HP:0004540)1.90614128
80Aplasia/hypoplasia of the uterus (HP:0008684)1.88850156
81Methylmalonic aciduria (HP:0012120)1.85752934
82Aplasia/Hypoplasia of the spleen (HP:0010451)1.85212690
83Postaxial foot polydactyly (HP:0001830)1.84995268
84Hepatic necrosis (HP:0002605)1.79960453
85IgG deficiency (HP:0004315)1.77737810
86Anencephaly (HP:0002323)1.76563651
87Hemiparesis (HP:0001269)1.75931311
88Agitation (HP:0000713)1.75702964
89Glycosuria (HP:0003076)1.75269498
90Abnormality of urine glucose concentration (HP:0011016)1.75269498
91Abnormality of the pons (HP:0007361)1.74695714
92Congenital sensorineural hearing impairment (HP:0008527)1.74598433
93Dynein arm defect of respiratory motile cilia (HP:0012255)1.74065275
94Absent/shortened dynein arms (HP:0200106)1.74065275
95Absent speech (HP:0001344)1.72252980
96Chorioretinal atrophy (HP:0000533)1.71923322
97Bony spicule pigmentary retinopathy (HP:0007737)1.71109425
98Generalized aminoaciduria (HP:0002909)1.70934321
99Hypoplasia of the fovea (HP:0007750)1.70134305
100Aplasia/Hypoplasia of the fovea (HP:0008060)1.70134305

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.78366774
2TAOK34.42775718
3ADRBK23.30437110
4MAP4K23.23271722
5ZAK3.10235817
6WNK32.48624881
7BMPR1B2.46599390
8GRK12.37654956
9TLK12.34451454
10NUAK12.34005614
11WNK42.26616404
12PINK12.22451632
13TXK1.73010839
14INSRR1.71076408
15BCKDK1.70758690
16TRIM281.70628985
17MAP3K41.67804997
18CASK1.65220276
19ACVR1B1.64116374
20OXSR11.60851247
21MAPK131.51596080
22DAPK21.36710061
23TIE11.32696664
24DYRK21.28880977
25STK391.28264216
26PAK31.09077319
27VRK11.08566413
28TNIK1.06536603
29MARK11.03529200
30ADRBK11.01322500
31CSNK1G21.00993386
32VRK20.96589797
33MST40.95235471
34PRKCE0.93862799
35PHKG10.93590668
36PHKG20.93590668
37CSNK1G30.92677681
38TAF10.92351449
39CSNK1G10.92349537
40PRKCG0.91200744
41MAP2K70.90695698
42CDK190.90485847
43IKBKB0.90484907
44ERBB30.90107391
45MAPKAPK30.89864365
46PIK3CA0.89082592
47CSNK1A1L0.83294751
48STK38L0.81062995
49TEC0.80876411
50BCR0.78474223
51TGFBR10.74283887
52MAP2K60.72983872
53EPHA40.72982155
54PLK20.72302217
55PRKCQ0.70753725
56MKNK20.68953540
57PTK2B0.68584497
58FGFR20.68091959
59PLK30.66335166
60MAPKAPK50.65501396
61BRSK20.65012748
62EIF2AK30.62479420
63MUSK0.61123967
64IRAK10.60729489
65GRK50.60142774
66ITK0.55027488
67PLK40.53264626
68CAMKK20.52633661
69MKNK10.51519992
70RPS6KA50.51431470
71NTRK30.48977196
72PRKACA0.47922673
73PNCK0.46945815
74NME10.46206743
75NEK20.46058816
76NLK0.45641810
77MAP2K20.45431083
78CHUK0.44015559
79SYK0.43346337
80CAMK2A0.42211872
81FLT30.41666588
82CSNK1A10.40655716
83STK110.40407939
84CSNK1D0.39804403
85PRKAA20.39398368
86NTRK20.38754191
87PRKCI0.38328062
88DYRK1A0.37772056
89EIF2AK20.36999074
90EPHA30.35449978
91KIT0.35380901
92PRKCA0.35347053
93PRKG10.34621842
94GRK70.34530672
95STK30.34104735
96TSSK60.33965001
97IKBKE0.33909298
98TNK20.32242165
99PRKAA10.31989657
100OBSCN0.30543406

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005913.20882610
2Caffeine metabolism_Homo sapiens_hsa002323.10836004
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.70657985
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.69378877
5Butanoate metabolism_Homo sapiens_hsa006502.47602686
6Phototransduction_Homo sapiens_hsa047442.33782524
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.27951406
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.23912955
9Nitrogen metabolism_Homo sapiens_hsa009102.21253319
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12685612
11Tryptophan metabolism_Homo sapiens_hsa003802.10887093
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.07396947
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.06817138
14Oxidative phosphorylation_Homo sapiens_hsa001901.97346309
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.81890235
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.78944928
17Ether lipid metabolism_Homo sapiens_hsa005651.78823539
18Retinol metabolism_Homo sapiens_hsa008301.78345712
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63837340
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.61867509
21Protein export_Homo sapiens_hsa030601.61547993
22* Chemical carcinogenesis_Homo sapiens_hsa052041.56349652
23Propanoate metabolism_Homo sapiens_hsa006401.52255755
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.51844138
25Arachidonic acid metabolism_Homo sapiens_hsa005901.51468395
26Nicotine addiction_Homo sapiens_hsa050331.50599748
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50576011
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48624098
29RNA polymerase_Homo sapiens_hsa030201.45554970
30Peroxisome_Homo sapiens_hsa041461.45058660
31Parkinsons disease_Homo sapiens_hsa050121.44545519
32Selenocompound metabolism_Homo sapiens_hsa004501.41605001
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.39742876
34Basal transcription factors_Homo sapiens_hsa030221.30445287
35One carbon pool by folate_Homo sapiens_hsa006701.24573302
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18705223
37Homologous recombination_Homo sapiens_hsa034401.10150991
38ABC transporters_Homo sapiens_hsa020101.09284952
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.07587288
40Taste transduction_Homo sapiens_hsa047421.07203218
41Olfactory transduction_Homo sapiens_hsa047401.06102541
42Fatty acid degradation_Homo sapiens_hsa000711.03688346
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03629584
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01040456
45Histidine metabolism_Homo sapiens_hsa003400.97763188
46Fanconi anemia pathway_Homo sapiens_hsa034600.97685711
47RNA degradation_Homo sapiens_hsa030180.96614057
48Sulfur metabolism_Homo sapiens_hsa009200.96198496
49beta-Alanine metabolism_Homo sapiens_hsa004100.94598807
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94430939
51Morphine addiction_Homo sapiens_hsa050320.93225968
52Regulation of autophagy_Homo sapiens_hsa041400.89919722
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89729630
54Alzheimers disease_Homo sapiens_hsa050100.88723426
55Primary immunodeficiency_Homo sapiens_hsa053400.87860430
56Huntingtons disease_Homo sapiens_hsa050160.87414209
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.83762208
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83143585
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82665276
60Sulfur relay system_Homo sapiens_hsa041220.80285580
61Cardiac muscle contraction_Homo sapiens_hsa042600.79954474
62Fat digestion and absorption_Homo sapiens_hsa049750.77815587
63Serotonergic synapse_Homo sapiens_hsa047260.77073699
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73022771
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.72142152
66Type I diabetes mellitus_Homo sapiens_hsa049400.72100645
67GABAergic synapse_Homo sapiens_hsa047270.71941637
68Proteasome_Homo sapiens_hsa030500.71537742
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71402619
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69600308
71Metabolic pathways_Homo sapiens_hsa011000.69085193
72Tyrosine metabolism_Homo sapiens_hsa003500.68606724
73Collecting duct acid secretion_Homo sapiens_hsa049660.65082869
74Insulin secretion_Homo sapiens_hsa049110.64782874
75Asthma_Homo sapiens_hsa053100.62008747
76Complement and coagulation cascades_Homo sapiens_hsa046100.61891112
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60858868
78Arginine biosynthesis_Homo sapiens_hsa002200.59421146
79Ovarian steroidogenesis_Homo sapiens_hsa049130.55957872
80Purine metabolism_Homo sapiens_hsa002300.55739991
81Glycerolipid metabolism_Homo sapiens_hsa005610.55323284
82Allograft rejection_Homo sapiens_hsa053300.52256401
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50725491
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.50699529
85Graft-versus-host disease_Homo sapiens_hsa053320.50380855
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50069206
87Circadian entrainment_Homo sapiens_hsa047130.48369332
88Arginine and proline metabolism_Homo sapiens_hsa003300.44897160
89Vitamin digestion and absorption_Homo sapiens_hsa049770.43463903
90Glutamatergic synapse_Homo sapiens_hsa047240.43155653
91Salivary secretion_Homo sapiens_hsa049700.42829606
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42771774
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42103200
94Fatty acid elongation_Homo sapiens_hsa000620.41866385
95Autoimmune thyroid disease_Homo sapiens_hsa053200.41478121
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40445612
97Bile secretion_Homo sapiens_hsa049760.39801978
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39735421
99Fatty acid metabolism_Homo sapiens_hsa012120.38928712
100Mineral absorption_Homo sapiens_hsa049780.38697796

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