CYP2C18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.59069298
2drug catabolic process (GO:0042737)8.97230312
3epoxygenase P450 pathway (GO:0019373)8.54989794
4cellular glucuronidation (GO:0052695)7.66426653
5uronic acid metabolic process (GO:0006063)7.34746764
6glucuronate metabolic process (GO:0019585)7.34746764
7urea metabolic process (GO:0019627)6.95095138
8omega-hydroxylase P450 pathway (GO:0097267)6.86921713
9negative regulation of fibrinolysis (GO:0051918)6.82440798
10regulation of fibrinolysis (GO:0051917)6.65683671
11drug metabolic process (GO:0017144)6.65315427
12glyoxylate metabolic process (GO:0046487)6.44614471
13nitrogen cycle metabolic process (GO:0071941)6.34254024
14fat-soluble vitamin biosynthetic process (GO:0042362)6.08420950
15L-phenylalanine catabolic process (GO:0006559)6.04214760
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.04214760
17urea cycle (GO:0000050)5.94955260
18regulation of triglyceride catabolic process (GO:0010896)5.81072077
19bile acid and bile salt transport (GO:0015721)5.80953128
20bile acid metabolic process (GO:0008206)5.77636652
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.66151796
22L-phenylalanine metabolic process (GO:0006558)5.66151796
23fibrinolysis (GO:0042730)5.63462885
24ethanol oxidation (GO:0006069)5.59843211
25regulation of protein activation cascade (GO:2000257)5.58831251
26complement activation, alternative pathway (GO:0006957)5.55538722
27oxidative demethylation (GO:0070989)5.52289999
28bile acid biosynthetic process (GO:0006699)5.35826750
29phenylpropanoid metabolic process (GO:0009698)5.35506471
30hormone catabolic process (GO:0042447)5.35111384
31negative regulation of cholesterol transport (GO:0032375)5.30954845
32negative regulation of sterol transport (GO:0032372)5.30954845
33regulation of complement activation (GO:0030449)5.18523462
34alkaloid metabolic process (GO:0009820)5.02195313
35peptidyl-glutamic acid carboxylation (GO:0017187)4.81182614
36protein carboxylation (GO:0018214)4.81182614
37phospholipid efflux (GO:0033700)4.78702955
38flavonoid metabolic process (GO:0009812)4.68416495
39very-low-density lipoprotein particle assembly (GO:0034379)4.68125673
40aromatic amino acid family catabolic process (GO:0009074)4.54030642
41blood coagulation, intrinsic pathway (GO:0007597)4.53769392
42ethanol metabolic process (GO:0006067)4.50263740
43negative regulation of hemostasis (GO:1900047)4.49764967
44negative regulation of blood coagulation (GO:0030195)4.49764967
45amino-acid betaine metabolic process (GO:0006577)4.49662842
46heme transport (GO:0015886)4.40716244
47daunorubicin metabolic process (GO:0044597)4.29079422
48polyketide metabolic process (GO:0030638)4.29079422
49doxorubicin metabolic process (GO:0044598)4.29079422
50arginine metabolic process (GO:0006525)4.26733540
51triglyceride homeostasis (GO:0070328)4.23386929
52acylglycerol homeostasis (GO:0055090)4.23386929
53fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.23293053
54regulation of bile acid biosynthetic process (GO:0070857)4.19490748
55triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.18062355
56angiotensin maturation (GO:0002003)4.13526464
57negative regulation of coagulation (GO:0050819)4.12480169
58regulation of cholesterol esterification (GO:0010872)4.12401873
59serine family amino acid catabolic process (GO:0009071)4.12058263
60intestinal absorption (GO:0050892)4.07806208
61regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.06492434
62positive regulation of triglyceride lipase activity (GO:0061365)4.05365950
63positive regulation of lipoprotein lipase activity (GO:0051006)4.05365950
64high-density lipoprotein particle remodeling (GO:0034375)4.04600973
65negative regulation of wound healing (GO:0061045)4.01285001
66cholesterol efflux (GO:0033344)3.98432788
67glycine metabolic process (GO:0006544)3.97198899
68S-adenosylmethionine metabolic process (GO:0046500)3.95948562
69plasma lipoprotein particle remodeling (GO:0034369)3.93972837
70protein-lipid complex remodeling (GO:0034368)3.93972837
71macromolecular complex remodeling (GO:0034367)3.93972837
72primary alcohol catabolic process (GO:0034310)3.92714947
73intestinal cholesterol absorption (GO:0030299)3.92470956
74regulation of plasminogen activation (GO:0010755)3.92358829
75protein activation cascade (GO:0072376)3.87184440
76drug transmembrane transport (GO:0006855)3.84033343
77aminoglycoside antibiotic metabolic process (GO:0030647)3.82150742
78complement activation, classical pathway (GO:0006958)3.75784306
79acute-phase response (GO:0006953)3.70123275
80negative regulation of lipase activity (GO:0060192)3.69758165
81complement activation (GO:0006956)3.65018005
82* xenobiotic metabolic process (GO:0006805)3.64872388
83lipoprotein transport (GO:0042953)3.64546754
84drug transport (GO:0015893)3.60647011
85NADH metabolic process (GO:0006734)3.60030593
86plasma lipoprotein particle assembly (GO:0034377)3.59982139
87vitamin biosynthetic process (GO:0009110)3.59624771
88fructose metabolic process (GO:0006000)3.59044853
89positive regulation of lipid catabolic process (GO:0050996)3.55612558
90reverse cholesterol transport (GO:0043691)3.51036147
91alpha-linolenic acid metabolic process (GO:0036109)3.39781038
92response to mercury ion (GO:0046689)3.39287277
93lipoprotein metabolic process (GO:0042157)3.36766477
94positive regulation of hemostasis (GO:1900048)3.33816964
95positive regulation of blood coagulation (GO:0030194)3.33816964
96negative regulation of fatty acid biosynthetic process (GO:0045717)3.33425223
97regulation of humoral immune response (GO:0002920)3.30527984
98tyrosine metabolic process (GO:0006570)3.29263605
99protein-lipid complex assembly (GO:0065005)3.24340493
100steroid catabolic process (GO:0006706)3.24046433

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.62523934
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.08936770
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.85221194
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.17424211
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.04953036
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.28218622
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.17529777
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.44420232
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.36903765
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.86152301
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.80118169
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.73748555
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.10892021
14* HNF4A_19822575_ChIP-Seq_HepG2_Human2.07206090
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.90234754
16GATA4_25053715_ChIP-Seq_YYC3_Human1.88737565
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.86684344
18SOX2_27498859_Chip-Seq_STOMACH_Mouse1.82443569
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.70635920
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62806760
21AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.57403591
22BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.54238885
23* GATA6_25053715_ChIP-Seq_YYC3_Human1.53022891
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.42861154
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42059963
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.38877415
27SOX2_20726797_ChIP-Seq_SW620_Human1.38047881
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33862042
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32914617
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28676472
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25425146
32FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25045706
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21201924
34HTT_18923047_ChIP-ChIP_STHdh_Human1.18534882
35GATA1_22025678_ChIP-Seq_K562_Human1.16975371
36FOXA1_25552417_ChIP-Seq_VCAP_Human1.13867469
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13079146
38FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12907126
39PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08661640
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.05223224
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02492176
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.00290234
43ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99551248
44BP1_19119308_ChIP-ChIP_Hs578T_Human0.98910191
45CEBPB_22108803_ChIP-Seq_LS180_Human0.97409040
46NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94173596
47TCF4_18268006_ChIP-ChIP_LS174T_Human0.93526854
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93165683
49* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92035875
50CDX2_22108803_ChIP-Seq_LS180_Human0.90243619
51CLOCK_20551151_ChIP-Seq_293T_Human0.90030519
52* HNFA_21074721_ChIP-Seq_CACO-2_Human0.89825142
53PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89656895
54KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88983919
55* CBP_21632823_ChIP-Seq_H3396_Human0.86275507
56LXR_22292898_ChIP-Seq_THP-1_Human0.86020597
57CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.85150876
58TP63_17297297_ChIP-ChIP_HaCaT_Human0.85035225
59ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84638769
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83060297
61RXRA_24833708_ChIP-Seq_LIVER_Mouse0.82949263
62BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.81369839
63PHF8_20622853_ChIP-Seq_HELA_Human0.77642802
64SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77600421
65SOX2_21211035_ChIP-Seq_LN229_Human0.76603723
66AR_20517297_ChIP-Seq_VCAP_Human0.74000132
67NFYA_21822215_ChIP-Seq_K562_Human0.73602418
68TP53_18474530_ChIP-ChIP_U2OS_Human0.73193481
69* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.71116992
70ESR1_15608294_ChIP-ChIP_MCF-7_Human0.70756281
71RARG_19884340_ChIP-ChIP_MEFs_Mouse0.70610979
72BCAT_22108803_ChIP-Seq_LS180_Human0.70400118
73P63_26484246_Chip-Seq_KERATINOCYTES_Human0.69463552
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.69219650
75ESR1_21235772_ChIP-Seq_MCF-7_Human0.69188225
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.66521235
77SA1_27219007_Chip-Seq_Bcells_Human0.65928249
78GATA6_21074721_ChIP-Seq_CACO-2_Human0.65705370
79P53_21459846_ChIP-Seq_SAOS-2_Human0.65442546
80* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.65299155
81FOXA1_21572438_ChIP-Seq_LNCaP_Human0.64886269
82* GATA3_24758297_ChIP-Seq_MCF-7_Human0.64473692
83ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.62446338
84JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.62371534
85* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.62352089
86EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.61700973
87TP63_23658742_ChIP-Seq_EP156T_Human0.60771191
88SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.60233613
89CBX2_22325352_ChIP-Seq_293T-Rex_Human0.60184418
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.60093124
91NANOG_20526341_ChIP-Seq_ESCs_Human0.59615186
92NFE2_27457419_Chip-Seq_LIVER_Mouse0.59511300
93RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59332365
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.59321955
95ETV1_20927104_ChIP-Seq_GIST48_Human0.58709802
96CTCF_27219007_Chip-Seq_Bcells_Human0.58559559
97PIAS1_25552417_ChIP-Seq_VCAP_Human0.57842264
98ERG_20517297_ChIP-Seq_VCAP_Human0.57460279
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.56870901
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.56214741

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.29687993
2MP0005360_urolithiasis7.48092387
3MP0005085_abnormal_gallbladder_physiolo6.55851713
4MP0005365_abnormal_bile_salt5.96686353
5MP0001666_abnormal_nutrient_absorption4.43342259
6MP0008875_abnormal_xenobiotic_pharmacok4.35438664
7MP0003252_abnormal_bile_duct3.86525105
8MP0002138_abnormal_hepatobiliary_system3.60428123
9MP0003195_calcinosis3.49548403
10MP0003868_abnormal_feces_composition3.36840153
11MP0009840_abnormal_foam_cell3.21370966
12MP0010329_abnormal_lipoprotein_level2.77913019
13MP0005332_abnormal_amino_acid2.39687066
14MP0004019_abnormal_vitamin_homeostasis2.32406816
15MP0003806_abnormal_nucleotide_metabolis2.22537708
16MP0009697_abnormal_copulation2.15870752
17MP0002876_abnormal_thyroid_physiology2.05283980
18MP0001764_abnormal_homeostasis1.73944064
19MP0000609_abnormal_liver_physiology1.72655004
20MP0002118_abnormal_lipid_homeostasis1.69833223
21MP0003183_abnormal_peptide_metabolism1.63308271
22MP0003191_abnormal_cellular_cholesterol1.58668456
23MP0009643_abnormal_urine_homeostasis1.41374625
24MP0005319_abnormal_enzyme/_coenzyme1.18501463
25MP0005584_abnormal_enzyme/coenzyme_acti1.14628064
26MP0005670_abnormal_white_adipose1.07819386
27MP0005636_abnormal_mineral_homeostasis1.05282912
28MP0004264_abnormal_extraembryonic_tissu1.01286432
29MP0004147_increased_porphyrin_level1.00001903
30MP0005451_abnormal_body_composition0.98295385
31MP0005408_hypopigmentation0.98140428
32MP0010155_abnormal_intestine_physiology0.98042124
33MP0010234_abnormal_vibrissa_follicle0.94034289
34MP0003879_abnormal_hair_cell0.91360687
35MP0009379_abnormal_foot_pigmentation0.88122926
36MP0003718_maternal_effect0.87346987
37MP0009642_abnormal_blood_homeostasis0.87091871
38MP0008469_abnormal_protein_level0.85305440
39MP0000598_abnormal_liver_morphology0.83090548
40MP0005409_darkened_coat_color0.79789192
41MP0005535_abnormal_body_temperature0.79636643
42MP0002971_abnormal_brown_adipose0.79548102
43MP0000604_amyloidosis0.75434925
44MP0005376_homeostasis/metabolism_phenot0.74100580
45MP0010368_abnormal_lymphatic_system0.71983845
46MP0005166_decreased_susceptibility_to0.70950019
47MP0005395_other_phenotype0.69708736
48MP0002136_abnormal_kidney_physiology0.68802275
49MP0009763_increased_sensitivity_to0.67528146
50MP0009764_decreased_sensitivity_to0.67412788
51MP0003638_abnormal_response/metabolism_0.66199611
52MP0003656_abnormal_erythrocyte_physiolo0.59063716
53MP0009053_abnormal_anal_canal0.58957213
54MP0001664_abnormal_digestion0.57742955
55MP0008872_abnormal_physiological_respon0.57581389
56MP0004043_abnormal_pH_regulation0.57572013
57MP0005448_abnormal_energy_balance0.56885889
58MP0002078_abnormal_glucose_homeostasis0.55732117
59MP0002132_abnormal_respiratory_system0.53457269
60MP0009785_altered_susceptibility_to0.52691661
61MP0005334_abnormal_fat_pad0.50356404
62MP0001756_abnormal_urination0.50048518
63MP0003186_abnormal_redox_activity0.48539030
64MP0000249_abnormal_blood_vessel0.48322466
65MP0000566_synostosis0.47543007
66MP0001661_extended_life_span0.47173643
67MP0003866_abnormal_defecation0.47173386
68MP0005266_abnormal_metabolism0.45578341
69MP0005023_abnormal_wound_healing0.45355922
70MP0000477_abnormal_intestine_morphology0.44788849
71MP0001845_abnormal_inflammatory_respons0.44502192
72MP0003011_delayed_dark_adaptation0.43822165
73MP0005464_abnormal_platelet_physiology0.43720742
74MP0004782_abnormal_surfactant_physiolog0.43121717
75MP0009115_abnormal_fat_cell0.42806161
76MP0001663_abnormal_digestive_system0.42397631
77MP0001765_abnormal_ion_homeostasis0.42194401
78MP0005058_abnormal_lysosome_morphology0.41216513
79MP0000538_abnormal_urinary_bladder0.40435363
80MP0002796_impaired_skin_barrier0.39921551
81MP0003300_gastrointestinal_ulcer0.38371961
82MP0008874_decreased_physiological_sensi0.36639158
83MP0006036_abnormal_mitochondrial_physio0.36448817
84MP0003953_abnormal_hormone_level0.35783254
85MP0000462_abnormal_digestive_system0.35561396
86MP0005187_abnormal_penis_morphology0.34587417
87MP0005381_digestive/alimentary_phenotyp0.34208703
88MP0003329_amyloid_beta_deposits0.32505954
89MP0002168_other_aberrant_phenotype0.31641771
90MP0000467_abnormal_esophagus_morphology0.31400137
91MP0002249_abnormal_larynx_morphology0.30247777
92MP0001881_abnormal_mammary_gland0.29377120
93MP0000490_abnormal_crypts_of0.29198115
94MP0009765_abnormal_xenobiotic_induced0.29067194
95MP0002098_abnormal_vibrissa_morphology0.28485247
96MP0003690_abnormal_glial_cell0.28294283
97MP0010352_gastrointestinal_tract_polyps0.27560517
98MP0005666_abnormal_adipose_tissue0.26651256
99MP0001915_intracranial_hemorrhage0.26269256
100MP0003959_abnormal_lean_body0.25130092

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)9.46178603
2Hypobetalipoproteinemia (HP:0003563)8.53731393
3Deep venous thrombosis (HP:0002625)7.93505735
4Abnormality of glutamine family amino acid metabolism (HP:0010902)6.88655937
5Complement deficiency (HP:0004431)6.83342647
6Prolonged partial thromboplastin time (HP:0003645)6.65996026
7Abnormality of aromatic amino acid family metabolism (HP:0004338)6.21641387
8Conjugated hyperbilirubinemia (HP:0002908)6.03124769
9Abnormality of complement system (HP:0005339)5.75210510
10Systemic lupus erythematosus (HP:0002725)5.70861419
11Fat malabsorption (HP:0002630)5.02222685
12Intrahepatic cholestasis (HP:0001406)4.87671575
13Xanthomatosis (HP:0000991)4.78036854
14Hypolipoproteinemia (HP:0010981)4.69896978
15Hyperlipoproteinemia (HP:0010980)4.53067189
16Joint hemorrhage (HP:0005261)4.39659458
17Abnormality of pyrimidine metabolism (HP:0004353)4.22819082
18Hydroxyprolinuria (HP:0003080)4.21990516
19Abnormality of proline metabolism (HP:0010907)4.21990516
20Glomerulonephritis (HP:0000099)4.19115114
21Steatorrhea (HP:0002570)4.00513327
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.91609916
23Hyperglycinuria (HP:0003108)3.82730437
24Abnormality of the common coagulation pathway (HP:0010990)3.77670568
25Abnormality of glycine metabolism (HP:0010895)3.64896390
26Abnormality of serine family amino acid metabolism (HP:0010894)3.64896390
27Hyperammonemia (HP:0001987)3.61689826
28Abnormality of vitamin metabolism (HP:0100508)3.54363976
29Malnutrition (HP:0004395)3.52247955
30Rickets (HP:0002748)3.46015385
31Nephritis (HP:0000123)3.36624659
32Generalized aminoaciduria (HP:0002909)3.34910306
33Glycosuria (HP:0003076)3.26564146
34Abnormality of urine glucose concentration (HP:0011016)3.26564146
35Spontaneous abortion (HP:0005268)3.12077246
36Hyperglycinemia (HP:0002154)3.04542384
37Hemorrhage of the eye (HP:0011885)2.98736666
38Abnormality of nucleobase metabolism (HP:0010932)2.98629179
39Abnormality of aspartate family amino acid metabolism (HP:0010899)2.91841155
40Abnormality of the intrinsic pathway (HP:0010989)2.88661889
41Osteomalacia (HP:0002749)2.88023987
42Hyperphosphaturia (HP:0003109)2.87614477
43Acanthocytosis (HP:0001927)2.87349478
44Recurrent gram-negative bacterial infections (HP:0005420)2.86627364
45Vascular calcification (HP:0004934)2.86379633
46Epidermoid cyst (HP:0200040)2.75514647
47Delayed CNS myelination (HP:0002188)2.70746467
48Hypercholesterolemia (HP:0003124)2.65371717
49Abnormal urine phosphate concentration (HP:0012599)2.59008853
50Proximal tubulopathy (HP:0000114)2.52727164
51Cardiovascular calcification (HP:0011915)2.51821183
52Metabolic acidosis (HP:0001942)2.50655663
53Hyperbilirubinemia (HP:0002904)2.47918824
54Abnormality of serum amino acid levels (HP:0003112)2.44833883
55Abnormality of purine metabolism (HP:0004352)2.41708807
56Irritability (HP:0000737)2.36825234
57Gingival bleeding (HP:0000225)2.36683048
58Widely patent fontanelles and sutures (HP:0004492)2.34411367
59Alkalosis (HP:0001948)2.33360349
60Abnormality of sulfur amino acid metabolism (HP:0004339)2.32947385
61Hypophosphatemia (HP:0002148)2.27608822
62Poikilocytosis (HP:0004447)2.26756812
63Mitral stenosis (HP:0001718)2.20674624
64Hypophosphatemic rickets (HP:0004912)2.17820502
65Abnormality of the vitamin B12 metabolism (HP:0004341)2.14952000
66Hypoalphalipoproteinemia (HP:0003233)2.12880780
67Nephrolithiasis (HP:0000787)2.09616047
68Abnormal enzyme/coenzyme activity (HP:0012379)2.09018696
69Elevated alkaline phosphatase (HP:0003155)2.07709562
70Abnormality of methionine metabolism (HP:0010901)2.07248170
71Abnormality of vitamin B metabolism (HP:0004340)2.06266912
72Nausea (HP:0002018)2.04216448
73Pigmentary retinal degeneration (HP:0001146)2.04037701
74Reduced antithrombin III activity (HP:0001976)2.03100016
75Abnormality of alkaline phosphatase activity (HP:0004379)2.02951179
76Confusion (HP:0001289)2.00014420
77Hepatocellular carcinoma (HP:0001402)1.98273533
78Cerebral palsy (HP:0100021)1.97209156
79Purpura (HP:0000979)1.96667191
80Potter facies (HP:0002009)1.94111182
81Facial shape deformation (HP:0011334)1.94111182
82Ileus (HP:0002595)1.90982185
83Gout (HP:0001997)1.89446818
84Abdominal distention (HP:0003270)1.88050298
85Increased purine levels (HP:0004368)1.86295627
86Hyperuricemia (HP:0002149)1.86295627
87Lethargy (HP:0001254)1.85125600
88Thrombophlebitis (HP:0004418)1.84454218
89Pancreatitis (HP:0001733)1.80188061
90Chronic diarrhea (HP:0002028)1.79567632
91Bifid scrotum (HP:0000048)1.78988991
92Pulmonary embolism (HP:0002204)1.76478845
93Joint swelling (HP:0001386)1.72564822
94Megaloblastic anemia (HP:0001889)1.72290867
95Focal segmental glomerulosclerosis (HP:0000097)1.70574716
96Abnormality of fatty-acid metabolism (HP:0004359)1.70387161
97Skin nodule (HP:0200036)1.69768134
98Dicarboxylic aciduria (HP:0003215)1.67572658
99Abnormality of dicarboxylic acid metabolism (HP:0010995)1.67572658
100Abnormality of the Achilles tendon (HP:0005109)1.66625083

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.15540535
2ERN15.12575493
3RIPK14.31942508
4MST1R4.10443251
5FGFR42.65044837
6MAP3K122.58714812
7PRKG22.45059608
8EPHA22.36020666
9TYK22.29404319
10PIK3CG2.12951261
11PIK3CA2.10580138
12MAP3K22.07184685
13EPHA31.83556134
14MAP3K31.77902274
15PRPF4B1.76386156
16PRKACG1.54135854
17MYLK1.52844979
18MET1.46911069
19FGFR31.45357915
20PDK21.38331872
21PTK61.35007828
22IRAK31.31782660
23TBK11.30768315
24PRKAA21.28124684
25ABL21.27263797
26EPHA41.27224178
27TESK21.27038581
28LMTK21.26541444
29STK391.25505486
30MAPK111.21316126
31NLK1.18246842
32PDPK11.18230285
33MAP3K11.16786038
34EPHB11.16229423
35OXSR11.15749757
36MAP3K101.06207967
37ERBB21.03220298
38PRKCZ0.94858971
39TRIB30.93243712
40FER0.93239767
41AKT30.89765379
42IGF1R0.86241606
43JAK10.83853120
44KSR20.82555601
45NEK90.82184423
46GRK60.82106077
47PDK10.80337068
48MAP3K110.79916027
49JAK20.75209648
50MAP2K20.75096406
51STK240.74579066
52PRKCA0.70010608
53SIK10.69945673
54MAP2K40.64708528
55RET0.60780668
56MAP3K50.59605616
57EPHB20.59132419
58ZAP700.57995510
59MAPKAPK30.57853434
60DYRK1B0.55760310
61CDK60.53218284
62NEK10.52985227
63PRKACA0.51832652
64TAOK10.50522539
65TNIK0.50274008
66MATK0.50211377
67CASK0.50092637
68SRC0.49927076
69PRKG10.48804232
70MST40.48000156
71CAMK2G0.46374404
72PINK10.43033998
73MAP2K60.40277064
74BMPR20.39299985
75MAP3K60.38876005
76NTRK30.38090898
77GRK10.38027814
78IRAK10.37521551
79PIM10.37130037
80ICK0.37026502
81PRKAA10.35700750
82PTK20.33623226
83PBK0.33011410
84TAOK30.33007338
85PRKCD0.32270606
86BCR0.32103629
87TESK10.31198270
88TAOK20.30948457
89CAMKK20.30729991
90CSF1R0.29742593
91PDGFRA0.29462505
92DDR20.29154966
93SCYL20.28574745
94IKBKE0.27998415
95MAP3K140.27608130
96DAPK20.25950027
97MAP4K10.25850881
98CDC42BPA0.25273351
99PIM20.24630558
100PRKCG0.24267889

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.85911446
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.80791432
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.47571299
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.36003860
5* Retinol metabolism_Homo sapiens_hsa008303.23359338
6Pentose and glucuronate interconversions_Homo sapiens_hsa000403.05751874
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.98919068
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.97201571
9Drug metabolism - other enzymes_Homo sapiens_hsa009832.96959285
10* Chemical carcinogenesis_Homo sapiens_hsa052042.90126894
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.75647101
12Complement and coagulation cascades_Homo sapiens_hsa046102.70620139
13Cyanoamino acid metabolism_Homo sapiens_hsa004602.69059494
14Arginine biosynthesis_Homo sapiens_hsa002202.41326893
15Fatty acid degradation_Homo sapiens_hsa000712.17321008
16Phenylalanine metabolism_Homo sapiens_hsa003602.17268860
17Starch and sucrose metabolism_Homo sapiens_hsa005002.05959209
18Bile secretion_Homo sapiens_hsa049762.04004779
19Histidine metabolism_Homo sapiens_hsa003402.02507427
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.02188455
21Linoleic acid metabolism_Homo sapiens_hsa005912.00634246
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.98594860
23Fat digestion and absorption_Homo sapiens_hsa049751.96423778
24Butanoate metabolism_Homo sapiens_hsa006501.93118191
25Tryptophan metabolism_Homo sapiens_hsa003801.88563341
26Tyrosine metabolism_Homo sapiens_hsa003501.73958167
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62604159
28PPAR signaling pathway_Homo sapiens_hsa033201.59024881
29Vitamin digestion and absorption_Homo sapiens_hsa049771.46201949
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33212627
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30640716
32Arachidonic acid metabolism_Homo sapiens_hsa005901.23542214
33Peroxisome_Homo sapiens_hsa041461.22909425
34Renin-angiotensin system_Homo sapiens_hsa046141.15496255
35Arginine and proline metabolism_Homo sapiens_hsa003301.13468016
36beta-Alanine metabolism_Homo sapiens_hsa004101.06276688
37Vitamin B6 metabolism_Homo sapiens_hsa007501.02599492
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01045923
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95279108
40Staphylococcus aureus infection_Homo sapiens_hsa051500.94960130
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91074456
42Fatty acid metabolism_Homo sapiens_hsa012120.90313377
43Pyruvate metabolism_Homo sapiens_hsa006200.89178259
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87914536
45Maturity onset diabetes of the young_Homo sapiens_hsa049500.86476040
46Sulfur metabolism_Homo sapiens_hsa009200.85675610
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85637217
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85137022
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.84222798
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83521647
51Propanoate metabolism_Homo sapiens_hsa006400.81682882
52Biosynthesis of amino acids_Homo sapiens_hsa012300.81378233
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77226061
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76588393
55Carbon metabolism_Homo sapiens_hsa012000.73976562
56Fructose and mannose metabolism_Homo sapiens_hsa000510.73185036
57Mineral absorption_Homo sapiens_hsa049780.69080780
58ABC transporters_Homo sapiens_hsa020100.67008781
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64077083
60Glycerolipid metabolism_Homo sapiens_hsa005610.57238165
61Galactose metabolism_Homo sapiens_hsa000520.56046250
62Protein digestion and absorption_Homo sapiens_hsa049740.50845989
63Prion diseases_Homo sapiens_hsa050200.50205296
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48914658
65Sulfur relay system_Homo sapiens_hsa041220.41670976
66* Metabolic pathways_Homo sapiens_hsa011000.39456090
67Lysine degradation_Homo sapiens_hsa003100.31382258
68Glutathione metabolism_Homo sapiens_hsa004800.30961483
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29892035
70Fatty acid elongation_Homo sapiens_hsa000620.29633144
71Pentose phosphate pathway_Homo sapiens_hsa000300.26784996
72Insulin resistance_Homo sapiens_hsa049310.18568555
73Pertussis_Homo sapiens_hsa051330.17333649
74Folate biosynthesis_Homo sapiens_hsa007900.16051841
75Fatty acid biosynthesis_Homo sapiens_hsa000610.13709163
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12756888
77Ether lipid metabolism_Homo sapiens_hsa005650.12338251
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.11163235
79Sphingolipid metabolism_Homo sapiens_hsa006000.11053292
80One carbon pool by folate_Homo sapiens_hsa006700.10232558
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.08650085
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.04981902
83Other glycan degradation_Homo sapiens_hsa005110.04914611
84Glucagon signaling pathway_Homo sapiens_hsa049220.04734880
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.2062340
86Nitrogen metabolism_Homo sapiens_hsa00910-0.1939446
87Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1841227
88Hepatitis C_Homo sapiens_hsa05160-0.1635345
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1320453
90Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1319845
91African trypanosomiasis_Homo sapiens_hsa05143-0.1266356
92Amoebiasis_Homo sapiens_hsa05146-0.1252048
93* Serotonergic synapse_Homo sapiens_hsa04726-0.1186674
94Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1090514
95Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0769471
96AMPK signaling pathway_Homo sapiens_hsa04152-0.0684452
97Steroid biosynthesis_Homo sapiens_hsa00100-0.0648106
98Pancreatic secretion_Homo sapiens_hsa04972-0.0638904
99Selenocompound metabolism_Homo sapiens_hsa00450-0.0404833
100Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0365300

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