CYP2A7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibrinolysis (GO:0051918)9.36624402
2regulation of fibrinolysis (GO:0051917)8.69862019
3cellular glucuronidation (GO:0052695)8.08386809
4glyoxylate metabolic process (GO:0046487)7.94341719
5fibrinolysis (GO:0042730)7.69921980
6glucuronate metabolic process (GO:0019585)7.69256504
7uronic acid metabolic process (GO:0006063)7.69256504
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.17508864
9L-phenylalanine catabolic process (GO:0006559)7.17508864
10epoxygenase P450 pathway (GO:0019373)6.87170527
11oxidative demethylation (GO:0070989)6.74166625
12urea metabolic process (GO:0019627)6.70184857
13L-phenylalanine metabolic process (GO:0006558)6.64668967
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.64668967
15fat-soluble vitamin biosynthetic process (GO:0042362)6.64049091
16omega-hydroxylase P450 pathway (GO:0097267)6.56679021
17phenylpropanoid metabolic process (GO:0009698)6.41763326
18bile acid biosynthetic process (GO:0006699)6.39436303
19negative regulation of cholesterol transport (GO:0032375)6.18675282
20negative regulation of sterol transport (GO:0032372)6.18675282
21nitrogen cycle metabolic process (GO:0071941)6.08725823
22drug metabolic process (GO:0017144)6.08268384
23polyketide metabolic process (GO:0030638)6.06297954
24doxorubicin metabolic process (GO:0044598)6.06297954
25daunorubicin metabolic process (GO:0044597)6.06297954
26bile acid metabolic process (GO:0008206)5.80819450
27amino-acid betaine metabolic process (GO:0006577)5.67888995
28peptidyl-glutamic acid carboxylation (GO:0017187)5.67697468
29protein carboxylation (GO:0018214)5.67697468
30aromatic amino acid family catabolic process (GO:0009074)5.61730891
31alkaloid metabolic process (GO:0009820)5.52458799
32blood coagulation, intrinsic pathway (GO:0007597)5.46009379
33bile acid and bile salt transport (GO:0015721)5.42434404
34regulation of plasminogen activation (GO:0010755)5.42346842
35aminoglycoside antibiotic metabolic process (GO:0030647)5.38575215
36glycine metabolic process (GO:0006544)5.33765474
37serine family amino acid catabolic process (GO:0009071)5.32416106
38negative regulation of blood coagulation (GO:0030195)5.27215120
39negative regulation of hemostasis (GO:1900047)5.27215120
40regulation of protein activation cascade (GO:2000257)5.22792142
41urea cycle (GO:0000050)5.16804604
42ethanol oxidation (GO:0006069)5.08213942
43S-adenosylmethionine metabolic process (GO:0046500)4.96129860
44regulation of triglyceride catabolic process (GO:0010896)4.87741830
45negative regulation of coagulation (GO:0050819)4.79804343
46regulation of complement activation (GO:0030449)4.73591890
47phospholipid efflux (GO:0033700)4.71405610
48intestinal cholesterol absorption (GO:0030299)4.69382707
49triglyceride homeostasis (GO:0070328)4.68118341
50acylglycerol homeostasis (GO:0055090)4.68118341
51negative regulation of wound healing (GO:0061045)4.64829379
52negative regulation of fatty acid biosynthetic process (GO:0045717)4.62566670
53heme transport (GO:0015886)4.59311843
54primary alcohol catabolic process (GO:0034310)4.50185612
55very-low-density lipoprotein particle assembly (GO:0034379)4.42932349
56amino acid salvage (GO:0043102)4.41014049
57L-methionine salvage (GO:0071267)4.41014049
58L-methionine biosynthetic process (GO:0071265)4.41014049
59alpha-linolenic acid metabolic process (GO:0036109)4.39627735
60positive regulation of hemostasis (GO:1900048)4.38963377
61positive regulation of blood coagulation (GO:0030194)4.38963377
62complement activation, alternative pathway (GO:0006957)4.38252104
63hormone catabolic process (GO:0042447)4.33973330
64negative regulation of lipase activity (GO:0060192)4.32710385
65tryptophan catabolic process (GO:0006569)4.23261581
66indole-containing compound catabolic process (GO:0042436)4.23261581
67indolalkylamine catabolic process (GO:0046218)4.23261581
68response to mercury ion (GO:0046689)4.22995188
69ethanol metabolic process (GO:0006067)4.11183785
70serine family amino acid metabolic process (GO:0009069)4.08875508
71positive regulation of coagulation (GO:0050820)4.07807289
72steroid catabolic process (GO:0006706)4.07692725
73regulation of lipoprotein particle clearance (GO:0010984)4.01208385
74arginine metabolic process (GO:0006525)4.00898261
75fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.00498224
76vitamin biosynthetic process (GO:0009110)3.99183986
77flavonoid metabolic process (GO:0009812)3.96777825
78tyrosine metabolic process (GO:0006570)3.93565703
79xenobiotic metabolic process (GO:0006805)3.88119462
80drug transmembrane transport (GO:0006855)3.86130625
81high-density lipoprotein particle remodeling (GO:0034375)3.84474546
82positive regulation of immune response to tumor cell (GO:0002839)3.76494689
83regulation of immune response to tumor cell (GO:0002837)3.76494689
84regulation of response to tumor cell (GO:0002834)3.76494689
85positive regulation of response to tumor cell (GO:0002836)3.76494689
86cholesterol efflux (GO:0033344)3.72252491
87aromatic amino acid family metabolic process (GO:0009072)3.62872710
88regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.59468649
89androgen metabolic process (GO:0008209)3.55550573
90negative regulation of fatty acid metabolic process (GO:0045922)3.49989298
91protein-lipid complex remodeling (GO:0034368)3.48565683
92macromolecular complex remodeling (GO:0034367)3.48565683
93plasma lipoprotein particle remodeling (GO:0034369)3.48565683
94tryptophan metabolic process (GO:0006568)3.45300544
95acute-phase response (GO:0006953)3.43404104
96sodium-independent organic anion transport (GO:0043252)3.42476251
97carnitine metabolic process (GO:0009437)3.40898676
98plasma lipoprotein particle clearance (GO:0034381)3.39271364
99exogenous drug catabolic process (GO:0042738)12.2107140
100drug catabolic process (GO:0042737)10.6822929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.04963579
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.45444124
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.97253356
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.68509476
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.10137344
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.82614564
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.71087832
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.37443927
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.79466876
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.35431287
11HNF4A_19822575_ChIP-Seq_HepG2_Human2.27371578
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.21849610
13FOXA2_19822575_ChIP-Seq_HepG2_Human2.16954784
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.9871288
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72933121
16* ESR1_20079471_ChIP-ChIP_T-47D_Human1.53101282
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42664582
18HTT_18923047_ChIP-ChIP_STHdh_Human1.38273291
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37026561
20AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.34209579
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28458132
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.21410220
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19255796
24RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15546600
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11848707
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11071713
27CBP_21632823_ChIP-Seq_H3396_Human1.06219226
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.04792676
29SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03068333
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.02441074
31CEBPB_22108803_ChIP-Seq_LS180_Human1.02028563
32GATA4_25053715_ChIP-Seq_YYC3_Human1.01369743
33BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99101611
34ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98050383
35FOXA1_25552417_ChIP-Seq_VCAP_Human0.97734236
36FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96615670
37IGF1R_20145208_ChIP-Seq_DFB_Human0.94752918
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94410145
39SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88861151
40SOX2_21211035_ChIP-Seq_LN229_Human0.85015706
41TRIM28_21343339_ChIP-Seq_HEK293_Human0.84084535
42HNFA_21074721_ChIP-Seq_CACO-2_Human0.84044199
43TP53_18474530_ChIP-ChIP_U2OS_Human0.82287807
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.80196130
45* GATA6_25053715_ChIP-Seq_YYC3_Human0.80114180
46IRF1_19129219_ChIP-ChIP_H3396_Human0.78695547
47PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78134606
48NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76649823
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76649823
50KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76341041
51CDX2_19796622_ChIP-Seq_MESCs_Mouse0.75583928
52KLF5_20875108_ChIP-Seq_MESCs_Mouse0.74913273
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73249136
54PIAS1_25552417_ChIP-Seq_VCAP_Human0.72658750
55* CDX2_20551321_ChIP-Seq_CACO-2_Human0.70152978
56SOX2_20726797_ChIP-Seq_SW620_Human0.69649931
57AR_20517297_ChIP-Seq_VCAP_Human0.69629796
58PHF8_20622853_ChIP-Seq_HELA_Human0.68443412
59CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.66760813
60P53_21459846_ChIP-Seq_SAOS-2_Human0.65843873
61FOXA1_21572438_ChIP-Seq_LNCaP_Human0.65465597
62CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.65384223
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.65008378
64PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.64732301
65FOXH1_21741376_ChIP-Seq_EPCs_Human0.63723895
66CJUN_26792858_Chip-Seq_BT549_Human0.62369176
67NFE2_27457419_Chip-Seq_LIVER_Mouse0.60234180
68FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.60084286
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.59570142
70NFYA_21822215_ChIP-Seq_K562_Human0.59467857
71GATA3_24758297_ChIP-Seq_MCF-7_Human0.58952454
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.58691622
73RARG_19884340_ChIP-ChIP_MEFs_Mouse0.58568618
74FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.58353198
75AUTS2_25519132_ChIP-Seq_293T-REX_Human0.57360349
76EZH2_27294783_Chip-Seq_NPCs_Mouse0.56151609
77NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.55356821
78FOXO3_23340844_ChIP-Seq_DLD1_Human0.54777485
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.54126287
80PCGF2_27294783_Chip-Seq_NPCs_Mouse0.54056982
81CDX2_22108803_ChIP-Seq_LS180_Human0.53852288
82CLOCK_20551151_ChIP-Seq_293T_Human0.53846123
83SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.53831674
84RARA_24833708_ChIP-Seq_LIVER_Mouse0.53646650
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.53375064
86ERG_20517297_ChIP-Seq_VCAP_Human0.53342438
87BCAT_22108803_ChIP-Seq_LS180_Human0.52377255
88ELF1_20517297_ChIP-Seq_JURKAT_Human0.52241656
89SPI1_20517297_ChIP-Seq_HL60_Human0.51269837
90GATA2_21666600_ChIP-Seq_HMVEC_Human0.51262700
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.50687982
92P63_26484246_Chip-Seq_KERATINOCYTES_Human0.49623005
93GATA3_21867929_ChIP-Seq_CD8_Mouse0.49436517
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.49236528
95CBP_20019798_ChIP-Seq_JUKART_Human0.49236528
96EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.49217132
97ER_23166858_ChIP-Seq_MCF-7_Human0.48175512
98* RAC3_21632823_ChIP-Seq_H3396_Human0.48085383
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.47756235
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.47225747

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005365_abnormal_bile_salt6.19900782
2MP0005085_abnormal_gallbladder_physiolo6.00936662
3MP0008875_abnormal_xenobiotic_pharmacok5.33451243
4MP0005360_urolithiasis5.16352565
5MP0003195_calcinosis4.91906460
6MP0002138_abnormal_hepatobiliary_system4.26976815
7MP0003252_abnormal_bile_duct4.26241275
8MP0003868_abnormal_feces_composition3.74318019
9MP0001666_abnormal_nutrient_absorption3.59804800
10MP0009840_abnormal_foam_cell3.07907025
11MP0009697_abnormal_copulation2.68901977
12MP0010329_abnormal_lipoprotein_level2.51670758
13MP0003806_abnormal_nucleotide_metabolis2.25976821
14MP0002876_abnormal_thyroid_physiology2.14884672
15MP0005332_abnormal_amino_acid2.11379390
16MP0002139_abnormal_hepatobiliary_system11.3241026
17MP0000609_abnormal_liver_physiology1.79473862
18MP0002118_abnormal_lipid_homeostasis1.60867293
19MP0001764_abnormal_homeostasis1.52542182
20MP0003191_abnormal_cellular_cholesterol1.27984198
21MP0005319_abnormal_enzyme/_coenzyme1.21569377
22MP0005408_hypopigmentation1.21441623
23MP0009053_abnormal_anal_canal1.18709234
24MP0005584_abnormal_enzyme/coenzyme_acti1.07584157
25MP0003656_abnormal_erythrocyte_physiolo1.01688277
26MP0005451_abnormal_body_composition0.99943771
27MP0004019_abnormal_vitamin_homeostasis0.97215955
28MP0009643_abnormal_urine_homeostasis0.92355405
29MP0003011_delayed_dark_adaptation0.89419455
30MP0001661_extended_life_span0.89236939
31MP0000598_abnormal_liver_morphology0.88156317
32MP0003186_abnormal_redox_activity0.87899599
33MP0005376_homeostasis/metabolism_phenot0.76558545
34MP0009642_abnormal_blood_homeostasis0.76378184
35MP0008469_abnormal_protein_level0.75706397
36MP0009763_increased_sensitivity_to0.72909113
37MP0001915_intracranial_hemorrhage0.71681168
38MP0003879_abnormal_hair_cell0.70321088
39MP0003638_abnormal_response/metabolism_0.68115350
40MP0005395_other_phenotype0.67850797
41MP0005636_abnormal_mineral_homeostasis0.66861753
42MP0005187_abnormal_penis_morphology0.65913346
43MP0000604_amyloidosis0.64261581
44MP0005464_abnormal_platelet_physiology0.63165903
45MP0010368_abnormal_lymphatic_system0.62703316
46MP0006036_abnormal_mitochondrial_physio0.61803071
47MP0005023_abnormal_wound_healing0.60810740
48MP0002971_abnormal_brown_adipose0.59904800
49MP0003718_maternal_effect0.56560439
50MP0003690_abnormal_glial_cell0.54346365
51MP0002168_other_aberrant_phenotype0.52978180
52MP0003959_abnormal_lean_body0.52628750
53MP0005535_abnormal_body_temperature0.52140210
54MP0005266_abnormal_metabolism0.51767163
55MP0003300_gastrointestinal_ulcer0.51094920
56MP0009764_decreased_sensitivity_to0.48814799
57MP0008874_decreased_physiological_sensi0.46958043
58MP0005647_abnormal_sex_gland0.45976966
59MP0002132_abnormal_respiratory_system0.45917787
60MP0002078_abnormal_glucose_homeostasis0.45879023
61MP0003329_amyloid_beta_deposits0.45208037
62MP0005058_abnormal_lysosome_morphology0.43901790
63MP0008873_increased_physiological_sensi0.43609127
64MP0006035_abnormal_mitochondrial_morpho0.43382118
65MP0005670_abnormal_white_adipose0.41365346
66MP0005164_abnormal_response_to0.39394212
67MP0005334_abnormal_fat_pad0.37711040
68MP0004142_abnormal_muscle_tone0.37184055
69MP0000249_abnormal_blood_vessel0.36963387
70MP0004883_abnormal_blood_vessel0.35738297
71MP0001851_eye_inflammation0.30465863
72MP0005197_abnormal_uvea_morphology0.30331048
73MP0002282_abnormal_trachea_morphology0.29922282
74MP0002249_abnormal_larynx_morphology0.27851775
75MP0005084_abnormal_gallbladder_morpholo0.27266376
76MP0005448_abnormal_energy_balance0.27002403
77MP0009785_altered_susceptibility_to0.25881516
78MP0003075_altered_response_to0.24644178
79MP0001756_abnormal_urination0.23106145
80MP0002928_abnormal_bile_duct0.22911287
81MP0003632_abnormal_nervous_system0.22820538
82MP0002136_abnormal_kidney_physiology0.22690194
83MP0000920_abnormal_myelination0.21800771
84MP0000467_abnormal_esophagus_morphology0.21712085
85MP0001881_abnormal_mammary_gland0.21211248
86MP0002970_abnormal_white_adipose0.20903882
87MP0009765_abnormal_xenobiotic_induced0.19982150
88MP0008872_abnormal_physiological_respon0.19794338
89MP0003953_abnormal_hormone_level0.18633572
90MP0003566_abnormal_cell_adhesion0.18480158
91MP0002090_abnormal_vision0.18451344
92MP0005166_decreased_susceptibility_to0.17681942
93MP0004130_abnormal_muscle_cell0.16472391
94MP0001845_abnormal_inflammatory_respons0.16051274
95MP0005220_abnormal_exocrine_pancreas0.15762449
96MP0009115_abnormal_fat_cell0.13619550
97MP0000003_abnormal_adipose_tissue0.13305575
98MP0005330_cardiomyopathy0.13083742
99MP0000858_altered_metastatic_potential0.12913650
100MP0005377_hearing/vestibular/ear_phenot0.12269238

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)8.63018175
2Prolonged partial thromboplastin time (HP:0003645)8.43719667
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.93208554
4Conjugated hyperbilirubinemia (HP:0002908)6.80099009
5Complement deficiency (HP:0004431)5.81038105
6Hyperlipoproteinemia (HP:0010980)5.65469598
7Joint hemorrhage (HP:0005261)5.49136882
8Intrahepatic cholestasis (HP:0001406)5.44631793
9Abnormality of complement system (HP:0005339)4.96446465
10Systemic lupus erythematosus (HP:0002725)4.93405623
11Hypolipoproteinemia (HP:0010981)4.84196146
12Abnormality of the common coagulation pathway (HP:0010990)4.67766521
13Xanthomatosis (HP:0000991)4.57962543
14Fat malabsorption (HP:0002630)4.52723608
15Rickets (HP:0002748)4.41581900
16Abnormality of pyrimidine metabolism (HP:0004353)4.37592147
17Steatorrhea (HP:0002570)4.31514176
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.09004975
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.91235569
20Hyperglycinemia (HP:0002154)3.85904829
21Abnormality of the intrinsic pathway (HP:0010989)3.67560892
22Vascular calcification (HP:0004934)3.59946101
23Generalized aminoaciduria (HP:0002909)3.57879563
24Mitral stenosis (HP:0001718)3.47388971
25Hyperammonemia (HP:0001987)3.44536300
26Glomerulonephritis (HP:0000099)3.43114840
27Spontaneous abortion (HP:0005268)3.39920808
28Hyperglycinuria (HP:0003108)3.34668249
29Hemorrhage of the eye (HP:0011885)3.33667365
30Hypochromic microcytic anemia (HP:0004840)3.30156854
31Cardiovascular calcification (HP:0011915)3.19301555
32Abnormality of glycine metabolism (HP:0010895)3.14114491
33Abnormality of serine family amino acid metabolism (HP:0010894)3.14114491
34Bifid scrotum (HP:0000048)3.11734521
35Nephritis (HP:0000123)3.08985364
36Hypercholesterolemia (HP:0003124)3.02956904
37Abnormality of vitamin metabolism (HP:0100508)2.94597750
38Abnormality of serum amino acid levels (HP:0003112)2.88273863
39Delayed CNS myelination (HP:0002188)2.85250289
40Reduced antithrombin III activity (HP:0001976)2.81650373
41Osteomalacia (HP:0002749)2.77726082
42Hyperphosphaturia (HP:0003109)2.66933624
43Gingival bleeding (HP:0000225)2.65096777
44Glycosuria (HP:0003076)2.62153164
45Abnormality of urine glucose concentration (HP:0011016)2.62153164
46Hyperbilirubinemia (HP:0002904)2.58586980
47Hypochromic anemia (HP:0001931)2.55733705
48Abnormality of methionine metabolism (HP:0010901)2.53839699
49Epidermoid cyst (HP:0200040)2.48010019
50Purpura (HP:0000979)2.43478609
51Recurrent gram-negative bacterial infections (HP:0005420)2.43176061
52Abnormality of the Achilles tendon (HP:0005109)2.40316624
53Abnormality of nucleobase metabolism (HP:0010932)2.39887275
54Irritability (HP:0000737)2.38950251
55Arthropathy (HP:0003040)2.34256962
56Metabolic acidosis (HP:0001942)2.24446322
57Hypophosphatemic rickets (HP:0004912)2.23132061
58Abnormality of aspartate family amino acid metabolism (HP:0010899)2.21642701
59Abnormal gallbladder physiology (HP:0012438)2.20471405
60Cholecystitis (HP:0001082)2.20471405
61Increased mean platelet volume (HP:0011877)2.20119272
62Hypoalphalipoproteinemia (HP:0003233)2.19620725
63Pulmonary embolism (HP:0002204)2.14499834
64Abnormal urine phosphate concentration (HP:0012599)2.14015617
65Poikilocytosis (HP:0004447)2.11678497
66Thrombophlebitis (HP:0004418)2.09325795
67Menorrhagia (HP:0000132)2.03174161
68Abnormality of monocarboxylic acid metabolism (HP:0010996)11.1221290
69Deep venous thrombosis (HP:0002625)10.2861947
70Myocardial infarction (HP:0001658)1.99538394
71Abnormal platelet volume (HP:0011876)1.99282177
72Cholelithiasis (HP:0001081)1.93932974
73Abnormal gallbladder morphology (HP:0012437)1.92967293
74Hydroxyprolinuria (HP:0003080)1.91863730
75Abnormality of proline metabolism (HP:0010907)1.91863730
76Retinal atrophy (HP:0001105)1.90028901
77Abnormality of fatty-acid metabolism (HP:0004359)1.89776673
78Abnormal platelet function (HP:0011869)1.84243784
79Impaired platelet aggregation (HP:0003540)1.84243784
80Back pain (HP:0003418)1.83615178
81Fair hair (HP:0002286)1.83509255
82Hepatocellular carcinoma (HP:0001402)1.82042224
83Elevated alkaline phosphatase (HP:0003155)1.81891060
84Bile duct proliferation (HP:0001408)1.81740668
85Abnormal biliary tract physiology (HP:0012439)1.81740668
86Atrioventricular block (HP:0001678)1.81060853
87Proximal tubulopathy (HP:0000114)1.78791804
88Submucous cleft hard palate (HP:0000176)1.74052180
89Ketosis (HP:0001946)1.73686470
90Abnormal enzyme/coenzyme activity (HP:0012379)1.72615795
91Neonatal onset (HP:0003623)1.71769586
92Abnormal tarsal ossification (HP:0008369)1.71698894
93Hypoglycemic coma (HP:0001325)1.70988480
94Joint swelling (HP:0001386)1.70126231
95Abnormality of sulfur amino acid metabolism (HP:0004339)1.70045655
96Acanthocytosis (HP:0001927)1.68386283
97Gangrene (HP:0100758)1.66524451
98Lethargy (HP:0001254)1.65594656
99Sensorimotor neuropathy (HP:0007141)1.62569093
100Abnormality of alkaline phosphatase activity (HP:0004379)1.60838748

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK14.43262048
2IRAK34.13521095
3ERN13.85000102
4MAP3K123.70097583
5MAP3K33.29441004
6PIK3CG3.12418339
7PRPF4B2.65318970
8FGFR42.51171098
9TYK22.41976481
10TBK12.21111060
11NTRK32.12247059
12ABL21.93816053
13PINK11.87468046
14PIK3CA1.87049811
15NEK91.85942912
16MYLK1.82028313
17PRKACG1.78387786
18MST1R1.67906649
19MAP3K21.63985519
20FGFR31.42527037
21MAP3K51.39726556
22MAP2K41.39178575
23EPHA31.37854512
24PRKCG1.37595058
25IGF1R1.37150333
26TRIB31.35916501
27TAOK21.31632845
28MAPK111.25424280
29BCR1.25306013
30MAP3K111.22795083
31ERBB41.21348872
32PRKAA21.20557416
33BCKDK1.20099631
34EIF2AK11.12961388
35MAP3K11.11691818
36KSR21.10527955
37SIK11.08844865
38JAK11.08190496
39JAK21.05226882
40MAP3K141.04177683
41PDPK11.03200469
42PRKCZ1.00950982
43MAPKAPK30.93073474
44EPHA40.85265588
45ZAP700.83484568
46MAP2K30.81965388
47SCYL20.80370210
48MAP3K60.77835116
49ACVR1B0.74494675
50NLK0.71754024
51ERBB20.71200538
52FRK0.70862143
53PRKG10.70647955
54PIM20.70010917
55RET0.69793617
56PRKACA0.68574265
57PRKAA10.67411108
58PTK60.67097246
59CSNK1D0.65356181
60TAOK10.65053187
61CAMKK20.63194915
62STK38L0.63129614
63FER0.63066359
64STK380.62358730
65PRKCB0.58964577
66EPHB10.57952541
67PDK10.57928713
68CDK120.57746756
69PRKCA0.56394349
70CAMK2G0.55419351
71ICK0.55085633
72TNK20.55071141
73CDK60.54755308
74STK160.51202993
75CHUK0.50552587
76TESK20.49027382
77DAPK20.48498929
78TAOK30.48358790
79LIMK10.48316689
80INSRR0.47705771
81ARAF0.44787392
82RPS6KA30.44733581
83MAP3K90.43236814
84SGK30.42562011
85GSK3A0.42085727
86SGK10.41884023
87DYRK1B0.40030951
88MUSK0.39469292
89MAPK40.37665478
90IKBKB0.36114539
91PBK0.35865181
92IKBKE0.35655483
93MAPK150.34687887
94MAP3K130.33344846
95RAF10.33115052
96DAPK30.31629032
97SRC0.31626876
98CASK0.31205360
99PAK30.29355607
100MET0.29138586

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002325.84588407
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.32499752
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.84242772
4Retinol metabolism_Homo sapiens_hsa008303.46345798
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.35514226
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.31351851
7Drug metabolism - other enzymes_Homo sapiens_hsa009833.23053925
8Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.12352638
9Chemical carcinogenesis_Homo sapiens_hsa052043.07537481
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.94089965
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.93269691
12Complement and coagulation cascades_Homo sapiens_hsa046102.79650966
13Butanoate metabolism_Homo sapiens_hsa006502.65492175
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.35090105
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.06735882
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.04982641
17Fatty acid degradation_Homo sapiens_hsa000712.04709191
18Phenylalanine metabolism_Homo sapiens_hsa003602.00004228
19Bile secretion_Homo sapiens_hsa049761.97423999
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.93660030
21Tryptophan metabolism_Homo sapiens_hsa003801.92998613
22Arginine biosynthesis_Homo sapiens_hsa002201.92923907
23Linoleic acid metabolism_Homo sapiens_hsa005911.76505716
24Tyrosine metabolism_Homo sapiens_hsa003501.66072580
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61589645
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.58905698
27Starch and sucrose metabolism_Homo sapiens_hsa005001.58619120
28Peroxisome_Homo sapiens_hsa041461.35480192
29beta-Alanine metabolism_Homo sapiens_hsa004101.32553729
30PPAR signaling pathway_Homo sapiens_hsa033201.30608092
31Histidine metabolism_Homo sapiens_hsa003401.30462367
32Vitamin B6 metabolism_Homo sapiens_hsa007501.29114966
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10669867
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08308388
35Fatty acid metabolism_Homo sapiens_hsa012121.07087011
36Propanoate metabolism_Homo sapiens_hsa006401.06254842
37Pyruvate metabolism_Homo sapiens_hsa006201.05354191
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.05348688
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96890825
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96664760
41Arachidonic acid metabolism_Homo sapiens_hsa005900.89128063
42Fat digestion and absorption_Homo sapiens_hsa049750.88189644
43Arginine and proline metabolism_Homo sapiens_hsa003300.88021539
44Carbon metabolism_Homo sapiens_hsa012000.81660383
45Biosynthesis of amino acids_Homo sapiens_hsa012300.75852144
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70694796
47Staphylococcus aureus infection_Homo sapiens_hsa051500.67295513
48Lysine degradation_Homo sapiens_hsa003100.66602368
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63320402
50ABC transporters_Homo sapiens_hsa020100.61179490
51One carbon pool by folate_Homo sapiens_hsa006700.57757072
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55777408
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54629501
54Steroid biosynthesis_Homo sapiens_hsa001000.50994563
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50578682
56Fatty acid elongation_Homo sapiens_hsa000620.45714284
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.41054367
58Metabolic pathways_Homo sapiens_hsa011000.40201471
59Sulfur metabolism_Homo sapiens_hsa009200.39603106
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37041003
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33046924
62Sulfur relay system_Homo sapiens_hsa041220.30764611
63Glycerolipid metabolism_Homo sapiens_hsa005610.25491647
64Prion diseases_Homo sapiens_hsa050200.24087663
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21305017
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.19620107
67Selenocompound metabolism_Homo sapiens_hsa004500.16877408
68Glutathione metabolism_Homo sapiens_hsa004800.16557559
69Pentose phosphate pathway_Homo sapiens_hsa000300.16049840
70Fructose and mannose metabolism_Homo sapiens_hsa000510.09455250
71Pertussis_Homo sapiens_hsa051330.09016514
72Insulin resistance_Homo sapiens_hsa049310.02168726
73Vitamin digestion and absorption_Homo sapiens_hsa049770.00518187
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2814921
75Circadian rhythm_Homo sapiens_hsa04710-0.2705148
76Lysosome_Homo sapiens_hsa04142-0.2628336
77Amoebiasis_Homo sapiens_hsa05146-0.2475211
78Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2331307
79N-Glycan biosynthesis_Homo sapiens_hsa00510-0.2238347
80Insulin signaling pathway_Homo sapiens_hsa04910-0.2225653
81Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2219440
82Type II diabetes mellitus_Homo sapiens_hsa04930-0.2110209
83Hepatitis C_Homo sapiens_hsa05160-0.2071404
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1917000
85Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1697412
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.1516451
87AMPK signaling pathway_Homo sapiens_hsa04152-0.1414086
88Mineral absorption_Homo sapiens_hsa04978-0.1368215
89Ether lipid metabolism_Homo sapiens_hsa00565-0.1307541
90Renin-angiotensin system_Homo sapiens_hsa04614-0.1281445
91African trypanosomiasis_Homo sapiens_hsa05143-0.1218769
92Glucagon signaling pathway_Homo sapiens_hsa04922-0.1166071
93Galactose metabolism_Homo sapiens_hsa00052-0.1156177
94Sphingolipid metabolism_Homo sapiens_hsa00600-0.0992428
95Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0542123
96Serotonergic synapse_Homo sapiens_hsa04726-0.0337866
97Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0287089
98Other glycan degradation_Homo sapiens_hsa00511-0.0279643
99Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0176409
100Folate biosynthesis_Homo sapiens_hsa00790-0.0084712

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