CYP2A13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)8.65478911
2exogenous drug catabolic process (GO:0042738)7.65508537
3left/right pattern formation (GO:0060972)7.61599200
4primary alcohol catabolic process (GO:0034310)7.21381298
5regulation of cilium movement (GO:0003352)7.12803213
6drug catabolic process (GO:0042737)6.69165041
7ethanol metabolic process (GO:0006067)6.41814397
8left/right axis specification (GO:0070986)6.39590550
9ventricular system development (GO:0021591)5.94936907
10vitamin transmembrane transport (GO:0035461)5.50991324
11response to xenobiotic stimulus (GO:0009410)5.41277397
12microtubule bundle formation (GO:0001578)5.32043385
13ethanol oxidation (GO:0006069)5.18632325
14cilium organization (GO:0044782)5.15412027
15intraciliary transport (GO:0042073)5.13375151
16cilium assembly (GO:0042384)5.03236815
17diterpenoid biosynthetic process (GO:0016102)4.91890764
18centriole assembly (GO:0098534)4.57504572
19establishment of apical/basal cell polarity (GO:0035089)4.47998307
20regulation of interleukin-5 production (GO:0032674)4.45792580
21glomerular epithelial cell development (GO:0072310)4.39001952
22pyrimidine-containing compound transmembrane transport (GO:0072531)4.38375841
23regulation of interleukin-13 production (GO:0032656)4.29937152
24regulation of microtubule-based movement (GO:0060632)4.22738445
25negative regulation of T cell differentiation in thymus (GO:0033085)4.12685209
26protein localization to cilium (GO:0061512)4.10127643
27tolerance induction (GO:0002507)4.09873610
28negative regulation of humoral immune response (GO:0002921)4.04774364
29negative regulation of immunoglobulin mediated immune response (GO:0002890)4.03472282
30negative regulation of B cell mediated immunity (GO:0002713)4.03472282
31sperm capacitation (GO:0048240)4.02786930
32microtubule-based movement (GO:0007018)3.99331252
33cellular component assembly involved in morphogenesis (GO:0010927)3.91400418
34lateral ventricle development (GO:0021670)3.90633899
35lung epithelium development (GO:0060428)3.88987623
36microtubule depolymerization (GO:0007019)3.87897108
37amino-acid betaine metabolic process (GO:0006577)3.87125829
38epoxygenase P450 pathway (GO:0019373)3.85199156
39establishment of monopolar cell polarity (GO:0061162)3.80769541
40establishment or maintenance of monopolar cell polarity (GO:0061339)3.80769541
41retinoic acid metabolic process (GO:0042573)3.75633159
42bile acid biosynthetic process (GO:0006699)3.75314305
43carnitine metabolic process (GO:0009437)3.69017781
44negative regulation of inclusion body assembly (GO:0090084)3.68852236
45primary alcohol metabolic process (GO:0034308)3.68314002
46nucleoside diphosphate phosphorylation (GO:0006165)3.65113318
47one-carbon compound transport (GO:0019755)3.62949652
48aldehyde catabolic process (GO:0046185)3.62429421
49cilium morphogenesis (GO:0060271)3.62387371
50cellular ketone body metabolic process (GO:0046950)3.59519541
51microtubule polymerization or depolymerization (GO:0031109)3.58412426
52cell projection assembly (GO:0030031)3.56664902
53fibrinolysis (GO:0042730)3.55248135
54cellular glucuronidation (GO:0052695)3.42201477
55sperm motility (GO:0030317)3.41486561
56drug metabolic process (GO:0017144)3.37401489
57glutathione derivative metabolic process (GO:1901685)3.36932961
58glutathione derivative biosynthetic process (GO:1901687)3.36932961
59glucuronate metabolic process (GO:0019585)3.29965879
60uronic acid metabolic process (GO:0006063)3.29965879
61terpenoid biosynthetic process (GO:0016114)3.28676867
62omega-hydroxylase P450 pathway (GO:0097267)3.28108939
63positive regulation of tolerance induction (GO:0002645)3.17097627
64oxidative demethylation (GO:0070989)3.15634112
65ketone body metabolic process (GO:1902224)3.15308039
66phenylpropanoid metabolic process (GO:0009698)3.06510996
67negative regulation of fibrinolysis (GO:0051918)3.05088057
68regulation of germinal center formation (GO:0002634)3.04701965
69phosphatidylethanolamine biosynthetic process (GO:0006646)3.01872682
70cytoplasmic microtubule organization (GO:0031122)3.01665952
71retinal metabolic process (GO:0042574)3.01458397
72hydrogen peroxide biosynthetic process (GO:0050665)2.99627426
73regulation of protein activation cascade (GO:2000257)2.96042905
74centriole replication (GO:0007099)2.94272331
75regulation of fibrinolysis (GO:0051917)2.91990193
76protein carboxylation (GO:0018214)2.89219684
77peptidyl-glutamic acid carboxylation (GO:0017187)2.89219684
78bile acid metabolic process (GO:0008206)2.88180529
79glyoxylate metabolic process (GO:0046487)2.85724080
80regulation of complement activation (GO:0030449)2.84897341
81organic cation transport (GO:0015695)2.84877352
82* xenobiotic metabolic process (GO:0006805)2.83892053
83L-ascorbic acid metabolic process (GO:0019852)2.83772289
84regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.82721396
85retinol metabolic process (GO:0042572)2.81785318
86phosphatidylethanolamine metabolic process (GO:0046337)2.81036130
87negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.80311605
88positive regulation of smoothened signaling pathway (GO:0045880)2.79346763
89determination of left/right symmetry (GO:0007368)2.78232420
90daunorubicin metabolic process (GO:0044597)2.77109067
91polyketide metabolic process (GO:0030638)2.77109067
92doxorubicin metabolic process (GO:0044598)2.77109067
93establishment of tissue polarity (GO:0007164)2.76266929
94establishment of planar polarity (GO:0001736)2.76266929
95axonemal dynein complex assembly (GO:0070286)18.9503547
96cilium or flagellum-dependent cell motility (GO:0001539)16.6396423
97cilium movement (GO:0003341)14.0682405
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)12.7693933
99motile cilium assembly (GO:0044458)12.4046049
100epithelial cilium movement (GO:0003351)11.7197852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.05508194
2DROSHA_22980978_ChIP-Seq_HELA_Human3.38097915
3FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.09801729
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.66982656
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.64587074
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.51284096
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.40230111
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.35151972
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.06674097
10LXR_22158963_ChIP-Seq_LIVER_Mouse1.98547960
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.98185124
12RXR_22158963_ChIP-Seq_LIVER_Mouse1.97281553
13PIAS1_25552417_ChIP-Seq_VCAP_Human1.94374537
14TRIM28_21343339_ChIP-Seq_HEK293_Human1.91869734
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.86989652
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82639983
17AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.82477156
18EGR1_23403033_ChIP-Seq_LIVER_Mouse1.78132817
19AHR_22903824_ChIP-Seq_MCF-7_Human1.77229192
20VDR_22108803_ChIP-Seq_LS180_Human1.76172056
21FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.71436978
22ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.70866406
23SMC4_20622854_ChIP-Seq_HELA_Human1.59153526
24TP53_18474530_ChIP-ChIP_U2OS_Human1.58908632
25ARNT_22903824_ChIP-Seq_MCF-7_Human1.58264302
26PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.51769463
27TP63_23658742_ChIP-Seq_EP156T_Human1.51768154
28STAT1_20625510_ChIP-Seq_HELA_Human1.50060142
29FOXM1_26456572_ChIP-Seq_MCF-7_Human1.48194095
30PPARA_22158963_ChIP-Seq_LIVER_Mouse1.46296939
31FOXA1_25552417_ChIP-Seq_VCAP_Human1.41287939
32ETV1_20927104_ChIP-Seq_GIST48_Human1.41205504
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39463479
34PHF8_20622853_ChIP-Seq_HELA_Human1.39075358
35RUNX1_27514584_Chip-Seq_MCF-7_Human1.38417419
36HNFA_21074721_ChIP-Seq_CACO-2_Human1.38361772
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.37866361
38TP63_22573176_ChIP-Seq_HFKS_Human1.37189543
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35514073
40KLF5_25053715_ChIP-Seq_YYC3_Human1.34509813
41NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33296378
42PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.32437315
43CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.32158523
44RAD21_21589869_ChIP-Seq_MESCs_Mouse1.30444254
45* TDRD3_21172665_ChIP-Seq_MCF-7_Human1.28863178
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.28477445
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28230530
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27520092
49SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26533912
50RBPJ_21746931_ChIP-Seq_IB4_Human1.26128875
51FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.25966789
52GATA4_25053715_ChIP-Seq_YYC3_Human1.25910807
53TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24428714
54P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24099017
55CTCF_20526341_ChIP-Seq_ESCs_Human1.23779375
56GATA1_19941826_ChIP-Seq_K562_Human1.23581066
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.22001472
58SMRT_27268052_Chip-Seq_Bcells_Human1.20948585
59FOXA2_19822575_ChIP-Seq_HepG2_Human1.20059633
60CBX2_22325352_ChIP-Seq_293T-Rex_Human1.19791856
61CDX2_20551321_ChIP-Seq_CACO-2_Human1.19740642
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18958790
63CEBPB_22108803_ChIP-Seq_LS180_Human1.18312520
64GATA6_21074721_ChIP-Seq_CACO-2_Human1.18203430
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14305185
66* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.13521693
67GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.13269595
68YY1_22570637_ChIP-Seq_MALME-3M_Human1.12951981
69P300_27268052_Chip-Seq_Bcells_Human1.12907863
70SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12251161
71* MYC_19829295_ChIP-Seq_ESCs_Human1.10872082
72SMAD4_21799915_ChIP-Seq_A2780_Human1.10464784
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09662817
74WDR5_24793694_ChIP-Seq_LNCAP_Human1.09253043
75SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08692155
76CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07685451
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.06621511
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06621511
79BCAT_22108803_ChIP-Seq_LS180_Human1.06370877
80STAT3_23295773_ChIP-Seq_U87_Human1.05280547
81PHF8_20622854_ChIP-Seq_HELA_Human1.05037730
82NFYA_21822215_ChIP-Seq_K562_Human1.04337456
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.03873912
84SOX2_21211035_ChIP-Seq_LN229_Human1.03471044
85ER_23166858_ChIP-Seq_MCF-7_Human1.01353899
86TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01037896
87OCT4_20526341_ChIP-Seq_ESCs_Human1.00862534
88* CTCF_27219007_Chip-Seq_Bcells_Human1.00426701
89NFYB_21822215_ChIP-Seq_K562_Human1.00320598
90SOX2_20726797_ChIP-Seq_SW620_Human0.99846904
91FOXO3_23340844_ChIP-Seq_DLD1_Human0.99126060
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98519513
93KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97939123
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97538903
95CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97336015
96SMAD3_21741376_ChIP-Seq_HESCs_Human0.97264402
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96945163
98AR_20517297_ChIP-Seq_VCAP_Human0.96887354
99SMAD3_21741376_ChIP-Seq_EPCs_Human0.96745074
100ERG_20517297_ChIP-Seq_VCAP_Human0.96531475

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok7.75686645
2MP0002139_abnormal_hepatobiliary_system6.10811644
3MP0002653_abnormal_ependyma_morphology5.75638159
4MP0002132_abnormal_respiratory_system4.92032591
5MP0005365_abnormal_bile_salt4.03206797
6MP0002277_abnormal_respiratory_mucosa3.57302953
7MP0001984_abnormal_olfaction3.42049325
8MP0005085_abnormal_gallbladder_physiolo3.39660977
9MP0004133_heterotaxia2.92078604
10MP0005623_abnormal_meninges_morphology2.78796707
11MP0004043_abnormal_pH_regulation2.77506699
12MP0000566_synostosis2.57006112
13MP0003195_calcinosis2.47198059
14MP0009780_abnormal_chondrocyte_physiolo2.43597996
15MP0003878_abnormal_ear_physiology2.38777766
16MP0005377_hearing/vestibular/ear_phenot2.38777766
17MP0008789_abnormal_olfactory_epithelium2.19191278
18MP0002282_abnormal_trachea_morphology2.03717232
19MP0004019_abnormal_vitamin_homeostasis2.01852700
20MP0002876_abnormal_thyroid_physiology1.99261183
21MP0001666_abnormal_nutrient_absorption1.88711656
22MP0002168_other_aberrant_phenotype1.84882288
23MP0003252_abnormal_bile_duct1.80766166
24MP0000383_abnormal_hair_follicle1.75937764
25MP0005360_urolithiasis1.68060163
26MP0003656_abnormal_erythrocyte_physiolo1.60451963
27MP0005395_other_phenotype1.54640820
28MP0001346_abnormal_lacrimal_gland1.53961192
29MP0001765_abnormal_ion_homeostasis1.31912080
30MP0005636_abnormal_mineral_homeostasis1.31677969
31MP0005394_taste/olfaction_phenotype1.28023935
32MP0005499_abnormal_olfactory_system1.28023935
33MP0010678_abnormal_skin_adnexa1.26326935
34MP0003806_abnormal_nucleotide_metabolis1.22493334
35MP0003868_abnormal_feces_composition1.16497189
36MP0009697_abnormal_copulation1.14752196
37MP0009643_abnormal_urine_homeostasis1.09970857
38MP0010329_abnormal_lipoprotein_level1.06004655
39MP0005408_hypopigmentation1.01509037
40MP0005410_abnormal_fertilization1.01236046
41MP0005083_abnormal_biliary_tract1.01013996
42MP0002909_abnormal_adrenal_gland0.98906176
43MP0003718_maternal_effect0.97305313
44MP0003698_abnormal_male_reproductive0.97163338
45MP0002233_abnormal_nose_morphology0.96602301
46MP0002249_abnormal_larynx_morphology0.94383005
47MP0002160_abnormal_reproductive_system0.92508912
48MP0005164_abnormal_response_to0.91634467
49MP0000678_abnormal_parathyroid_gland0.88908625
50MP0010030_abnormal_orbit_morphology0.86524971
51MP0005332_abnormal_amino_acid0.86455434
52MP0001929_abnormal_gametogenesis0.86414161
53MP0004883_abnormal_blood_vessel0.83794850
54MP0001764_abnormal_homeostasis0.80380739
55MP0001485_abnormal_pinna_reflex0.80151008
56MP0003638_abnormal_response/metabolism_0.79648442
57MP0005551_abnormal_eye_electrophysiolog0.79296527
58MP0002138_abnormal_hepatobiliary_system0.78758622
59MP0003011_delayed_dark_adaptation0.76306375
60MP0002136_abnormal_kidney_physiology0.75050866
61MP0003283_abnormal_digestive_organ0.74759739
62MP0005376_homeostasis/metabolism_phenot0.73296132
63MP0002098_abnormal_vibrissa_morphology0.69113480
64MP0002118_abnormal_lipid_homeostasis0.67274790
65MP0004782_abnormal_surfactant_physiolog0.65098639
66MP0002735_abnormal_chemical_nociception0.65090901
67MP0000609_abnormal_liver_physiology0.64813074
68MP0003879_abnormal_hair_cell0.64553318
69MP0008872_abnormal_physiological_respon0.64427480
70MP0001270_distended_abdomen0.62200221
71MP0009379_abnormal_foot_pigmentation0.60323954
72MP0002734_abnormal_mechanical_nocicepti0.60206253
73MP0005319_abnormal_enzyme/_coenzyme0.59859288
74MP0005165_increased_susceptibility_to0.59379528
75MP0002928_abnormal_bile_duct0.58243595
76MP0009763_increased_sensitivity_to0.53188801
77MP0002638_abnormal_pupillary_reflex0.52624535
78MP0000026_abnormal_inner_ear0.50182007
79MP0000467_abnormal_esophagus_morphology0.50145576
80MP0001324_abnormal_eye_pigmentation0.49826788
81MP0003941_abnormal_skin_development0.49549352
82MP0002161_abnormal_fertility/fecundity0.49546318
83MP0010155_abnormal_intestine_physiology0.49029014
84MP0003186_abnormal_redox_activity0.48794757
85MP0009642_abnormal_blood_homeostasis0.47750828
86MP0003950_abnormal_plasma_membrane0.45891197
87MP0005248_abnormal_Harderian_gland0.45845183
88MP0001293_anophthalmia0.44687672
89MP0000681_abnormal_thyroid_gland0.43740918
90MP0001881_abnormal_mammary_gland0.41592554
91MP0003937_abnormal_limbs/digits/tail_de0.41389892
92MP0005167_abnormal_blood-brain_barrier0.41209125
93MP0000249_abnormal_blood_vessel0.41140220
94MP0005220_abnormal_exocrine_pancreas0.41086724
95MP0000579_abnormal_nail_morphology0.40357792
96MP0001944_abnormal_pancreas_morphology0.40247548
97MP0002135_abnormal_kidney_morphology0.39952915
98MP0009046_muscle_twitch0.39210226
99MP0005389_reproductive_system_phenotype0.38526223
100MP0001849_ear_inflammation0.37693524

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.80946551
2Chronic bronchitis (HP:0004469)7.42783611
3Bronchiectasis (HP:0002110)7.15222809
4Nasal polyposis (HP:0100582)6.55641038
5Abnormality of the nasal mucosa (HP:0000433)5.39543843
6Recurrent sinusitis (HP:0011108)4.29273274
7Bronchitis (HP:0012387)4.19123641
8Infertility (HP:0000789)4.09186965
9Chronic sinusitis (HP:0011109)3.94519983
10Male infertility (HP:0003251)3.79841183
11Recurrent otitis media (HP:0000403)3.72587156
12Pancreatic fibrosis (HP:0100732)3.60910585
13Occipital encephalocele (HP:0002085)3.47918678
14True hermaphroditism (HP:0010459)3.38485786
15Chronic otitis media (HP:0000389)3.19667121
16Pancreatic cysts (HP:0001737)2.92277877
17Molar tooth sign on MRI (HP:0002419)2.90505721
18Abnormality of midbrain morphology (HP:0002418)2.90505721
19Cystic liver disease (HP:0006706)2.88650638
20Chronic hepatic failure (HP:0100626)2.81577324
21Nephronophthisis (HP:0000090)2.80423137
22Abnormality of monocarboxylic acid metabolism (HP:0010996)2.76530398
23Hyperactive renin-angiotensin system (HP:0000841)2.69774076
24Atelectasis (HP:0100750)2.57413363
25Postaxial foot polydactyly (HP:0001830)2.47294617
26Tubulointerstitial nephritis (HP:0001970)2.38591803
27Bell-shaped thorax (HP:0001591)2.30067530
28Abnormality of the renal medulla (HP:0100957)2.15631728
29Congenital hepatic fibrosis (HP:0002612)2.11838144
30Male pseudohermaphroditism (HP:0000037)2.10840911
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.0852083
32Abnormal respiratory epithelium morphology (HP:0012253)10.9146654
33Abnormal respiratory motile cilium morphology (HP:0005938)10.9146654
34Abnormal respiratory motile cilium physiology (HP:0012261)10.7984962
35Abnormal ciliary motility (HP:0012262)10.7405530
36Dynein arm defect of respiratory motile cilia (HP:0012255)10.7004950
37Absent/shortened dynein arms (HP:0200106)10.7004950
38Aplasia/Hypoplasia of the tongue (HP:0010295)1.98847975
39Anencephaly (HP:0002323)1.97314418
40Recurrent bronchitis (HP:0002837)1.96607412
41Absent frontal sinuses (HP:0002688)1.89905357
42Medial flaring of the eyebrow (HP:0010747)1.84694790
43Furrowed tongue (HP:0000221)1.84101725
44Sclerocornea (HP:0000647)1.72477937
45Decreased circulating renin level (HP:0003351)1.71013795
46Bifid scrotum (HP:0000048)1.70060540
47Congenital primary aphakia (HP:0007707)1.69644664
48Tubular atrophy (HP:0000092)1.68040991
49Gait imbalance (HP:0002141)1.67535086
50Asplenia (HP:0001746)1.67187074
51Nephropathy (HP:0000112)1.65308575
52Hyperkalemia (HP:0002153)1.63377781
53Aplasia/Hypoplasia of the spleen (HP:0010451)1.61005502
54Oculomotor apraxia (HP:0000657)1.54789577
55Postaxial hand polydactyly (HP:0001162)1.53397218
56Renal salt wasting (HP:0000127)1.50249880
57Deep venous thrombosis (HP:0002625)1.46011271
58Nephrogenic diabetes insipidus (HP:0009806)1.45298192
59Abnormal biliary tract physiology (HP:0012439)1.40878606
60Bile duct proliferation (HP:0001408)1.40878606
61Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.40016299
62Stage 5 chronic kidney disease (HP:0003774)1.32284794
63Preaxial hand polydactyly (HP:0001177)1.31801242
64Median cleft lip (HP:0000161)1.30551740
65Poor coordination (HP:0002370)1.27278055
66Decreased central vision (HP:0007663)1.26332489
67Genital tract atresia (HP:0001827)1.24344233
68Vascular calcification (HP:0004934)1.24246106
69Abnormality of renin-angiotensin system (HP:0000847)1.24221434
70Hyperaldosteronism (HP:0000859)1.23547606
71Hypobetalipoproteinemia (HP:0003563)1.23466193
72Vaginal atresia (HP:0000148)1.22377214
73Tubulointerstitial abnormality (HP:0001969)1.22038109
74Abnormality of chloride homeostasis (HP:0011422)1.21174095
75Abnormality of the frontal sinuses (HP:0002687)1.20581579
76Prolonged partial thromboplastin time (HP:0003645)1.19402840
77Abnormality of permanent molar morphology (HP:0011071)1.18338312
78Abnormality of the dental root (HP:0006486)1.18338312
79Taurodontia (HP:0000679)1.18338312
80Short thorax (HP:0010306)1.18137676
81Rickets (HP:0002748)1.13824546
82Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.13291435
83Cone-rod dystrophy (HP:0000548)1.12771420
84Hand muscle atrophy (HP:0009130)1.12196815
85Short nail (HP:0001799)1.10253843
86Polydipsia (HP:0001959)1.08537697
87Abnormal drinking behavior (HP:0030082)1.08537697
88Abnormality of the dental pulp (HP:0006479)1.08356738
89Abnormality of molar (HP:0011077)1.06425613
90Abnormality of molar morphology (HP:0011070)1.06425613
91Intrahepatic cholestasis (HP:0001406)1.05705477
92Self-mutilation (HP:0000742)1.05525438
93Supernumerary spleens (HP:0009799)1.05299220
94Cardiovascular calcification (HP:0011915)1.04139948
95Complement deficiency (HP:0004431)1.03356538
96Hyperglycinuria (HP:0003108)1.02509848
97Hypokalemic alkalosis (HP:0001949)1.01881027
98Abnormality of the renal cortex (HP:0011035)1.01644018
99Fat malabsorption (HP:0002630)1.01626965
100Abnormality of macular pigmentation (HP:0008002)1.00312314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.62320342
2EPHA23.99651563
3INSRR3.66177991
4PNCK2.89488590
5NME12.37495429
6MAPKAPK32.29694026
7MAPK1511.2583986
8SMG11.94816623
9MAP3K21.91659274
10PTK2B1.71291204
11TTK1.67027406
12MAP3K31.60430447
13EEF2K1.44552883
14STK241.44508252
15EPHA31.24520961
16CAMK1G1.23332636
17CAMKK21.20153950
18CAMK1D1.20017216
19BCR1.14849015
20ACVR1B1.11399061
21MST1R1.09985941
22CAMKK11.08286381
23TSSK61.05030493
24LRRK21.02916486
25MAP3K71.01390207
26EPHB11.00091824
27TLK10.96917579
28TBK10.95526334
29STK100.93577014
30CSK0.92640828
31TRPM70.87764563
32NEK60.85355901
33MAP3K40.80957228
34PLK40.80337236
35MAP3K120.77029605
36BMPR1B0.68942898
37EPHA40.67010431
38PRKCQ0.64090442
39FGFR20.63367682
40MAP2K70.61156698
41PRKAA20.60014783
42OXSR10.59987507
43TESK10.59877431
44MAPKAPK50.59631982
45PRKD30.59257723
46MAP4K20.57748074
47NEK90.57294845
48STK38L0.57043896
49STK160.56550237
50WNK40.53742511
51IRAK10.51743568
52GRK10.51608949
53MAP2K40.51414038
54PDPK10.50602846
55MARK20.50052118
56MAP2K20.49552610
57TRIB30.49015375
58STK380.48025578
59NLK0.46911408
60PRKCI0.46333036
61ERBB20.46061089
62PRKCD0.45690905
63PTK60.45293074
64CAMK2G0.42807321
65BRSK20.42396749
66PBK0.41464605
67SGK10.40111546
68WEE10.39904163
69RIPK10.38722017
70RIPK40.36976999
71ADRBK10.36771598
72PINK10.36314814
73PRKACA0.35373206
74RPS6KB20.35211317
75FRK0.31599334
76PIK3CG0.31071697
77MET0.30482802
78PASK0.30373760
79PRKCZ0.30019243
80AURKA0.29284337
81PRKCA0.27993491
82LATS10.27894251
83ICK0.27295768
84ERBB30.26486179
85PRKCG0.26468694
86DYRK1B0.25402480
87CHEK20.24278207
88MAPK130.23609864
89CAMK2A0.22953609
90GRK60.22035922
91CHUK0.21885983
92PRKG20.20462926
93TAOK10.20236364
94NTRK30.19722276
95AKT20.19696946
96FER0.19459728
97PRKG10.19118395
98MAP2K10.17330279
99FGFR40.16756680
100MYLK0.16257016

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.85690054
2* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.68475394
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.24793578
4* Chemical carcinogenesis_Homo sapiens_hsa052043.99148407
5Phenylalanine metabolism_Homo sapiens_hsa003603.52253542
6Histidine metabolism_Homo sapiens_hsa003403.14485157
7Retinol metabolism_Homo sapiens_hsa008303.11037625
8Linoleic acid metabolism_Homo sapiens_hsa005913.07451413
9Primary bile acid biosynthesis_Homo sapiens_hsa001203.06020749
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.90404385
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.78370218
12Tyrosine metabolism_Homo sapiens_hsa003502.75092260
13Steroid hormone biosynthesis_Homo sapiens_hsa001402.45732895
14beta-Alanine metabolism_Homo sapiens_hsa004102.45717107
15Butanoate metabolism_Homo sapiens_hsa006502.37882342
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22825764
17Drug metabolism - other enzymes_Homo sapiens_hsa009832.18737375
18Complement and coagulation cascades_Homo sapiens_hsa046101.90954548
19Fatty acid degradation_Homo sapiens_hsa000711.81016484
20Tryptophan metabolism_Homo sapiens_hsa003801.71459939
21Glutathione metabolism_Homo sapiens_hsa004801.56706327
22Peroxisome_Homo sapiens_hsa041461.53599742
23Starch and sucrose metabolism_Homo sapiens_hsa005001.51150308
24Huntingtons disease_Homo sapiens_hsa050161.50270361
25Arachidonic acid metabolism_Homo sapiens_hsa005901.44944434
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42225855
27Arginine biosynthesis_Homo sapiens_hsa002201.41224112
28ABC transporters_Homo sapiens_hsa020101.33674529
29Bile secretion_Homo sapiens_hsa049761.30470305
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13300591
31PPAR signaling pathway_Homo sapiens_hsa033201.11116677
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09146965
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06412374
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04506328
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.04493761
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94566204
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94441295
38Sphingolipid metabolism_Homo sapiens_hsa006000.88918797
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87296579
40Vitamin digestion and absorption_Homo sapiens_hsa049770.84317069
41Arginine and proline metabolism_Homo sapiens_hsa003300.79562882
42Fat digestion and absorption_Homo sapiens_hsa049750.68301368
43Pyruvate metabolism_Homo sapiens_hsa006200.64670579
44Propanoate metabolism_Homo sapiens_hsa006400.62806479
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62627936
46Glycerophospholipid metabolism_Homo sapiens_hsa005640.61134695
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57122215
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55287744
49Tight junction_Homo sapiens_hsa045300.55003002
50Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54590077
51Fatty acid biosynthesis_Homo sapiens_hsa000610.53627587
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.53271017
53Metabolic pathways_Homo sapiens_hsa011000.49979576
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44812877
55Fatty acid metabolism_Homo sapiens_hsa012120.44273439
56Ether lipid metabolism_Homo sapiens_hsa005650.43648996
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41729004
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40311819
59Nicotine addiction_Homo sapiens_hsa050330.37887428
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.36528276
61Vitamin B6 metabolism_Homo sapiens_hsa007500.34873550
62Steroid biosynthesis_Homo sapiens_hsa001000.30689251
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30452083
64Taste transduction_Homo sapiens_hsa047420.28725293
65Glycerolipid metabolism_Homo sapiens_hsa005610.27706784
66Salivary secretion_Homo sapiens_hsa049700.26448790
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24216926
68Serotonergic synapse_Homo sapiens_hsa047260.21138061
69Staphylococcus aureus infection_Homo sapiens_hsa051500.20839377
70Nitrogen metabolism_Homo sapiens_hsa009100.20502516
71Choline metabolism in cancer_Homo sapiens_hsa052310.16109891
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15104174
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15054764
74Hedgehog signaling pathway_Homo sapiens_hsa043400.14298731
75Sulfur relay system_Homo sapiens_hsa041220.13955980
76Olfactory transduction_Homo sapiens_hsa047400.13920947
77Carbon metabolism_Homo sapiens_hsa012000.13743046
78Biosynthesis of amino acids_Homo sapiens_hsa012300.11470386
79Sulfur metabolism_Homo sapiens_hsa009200.11153460
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10942449
81Cocaine addiction_Homo sapiens_hsa050300.10860983
82Insulin resistance_Homo sapiens_hsa049310.10397325
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.10331164
84Selenocompound metabolism_Homo sapiens_hsa004500.10239044
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.09154434
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.08722439
87Notch signaling pathway_Homo sapiens_hsa043300.07320802
88Circadian rhythm_Homo sapiens_hsa047100.06674932
89Ovarian steroidogenesis_Homo sapiens_hsa049130.04933765
90Hepatitis C_Homo sapiens_hsa051600.03832892
91N-Glycan biosynthesis_Homo sapiens_hsa005100.01973419
92Lysine degradation_Homo sapiens_hsa003100.01948775
93Mineral absorption_Homo sapiens_hsa049780.01738644
94Phototransduction_Homo sapiens_hsa047440.00175778
95Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0725048
96Amoebiasis_Homo sapiens_hsa05146-0.0614015
97cAMP signaling pathway_Homo sapiens_hsa04024-0.0606622
98Calcium signaling pathway_Homo sapiens_hsa04020-0.0575029
99Pentose phosphate pathway_Homo sapiens_hsa00030-0.0165862
100Pancreatic secretion_Homo sapiens_hsa04972-0.0143946

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